PRR15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.96081291
2cilium movement (GO:0003341)7.01799300
3motile cilium assembly (GO:0044458)6.93771511
4primary alcohol catabolic process (GO:0034310)6.56130259
5vitamin transmembrane transport (GO:0035461)6.47762336
6ribosomal small subunit assembly (GO:0000028)6.32503613
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.04240514
8ethanol metabolic process (GO:0006067)5.99981687
9epithelial cilium movement (GO:0003351)5.97141395
10DNA deamination (GO:0045006)5.78019006
11viral transcription (GO:0019083)5.68784486
12ethanol oxidation (GO:0006069)5.63761142
13regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.62232543
14phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.47523191
15translational termination (GO:0006415)5.45664571
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.09455370
17GDP-mannose metabolic process (GO:0019673)5.08433893
18mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.05376472
19negative regulation of metanephros development (GO:0072217)5.04451954
20calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.04063116
21nephron tubule formation (GO:0072079)5.00105643
22cotranslational protein targeting to membrane (GO:0006613)4.99045942
23pyrimidine-containing compound transmembrane transport (GO:0072531)4.96892389
24positive regulation of cellular amine metabolic process (GO:0033240)4.95381217
25protein targeting to ER (GO:0045047)4.94975050
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91674186
27ribosomal small subunit biogenesis (GO:0042274)4.90806369
28diterpenoid biosynthetic process (GO:0016102)4.84052464
29regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.76652596
30intestinal absorption (GO:0050892)4.76474778
31epoxygenase P450 pathway (GO:0019373)4.73554214
32protein localization to endoplasmic reticulum (GO:0070972)4.73224561
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.70487918
34translational elongation (GO:0006414)4.69473957
35pattern specification involved in kidney development (GO:0061004)4.68090908
36desmosome organization (GO:0002934)4.66051854
37lymphoid progenitor cell differentiation (GO:0002320)4.64277640
38regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.58838882
39telomere maintenance via semi-conservative replication (GO:0032201)4.57820562
40O-glycan processing (GO:0016266)4.56078185
41angiotensin maturation (GO:0002003)4.54287831
42regulation of apoptotic process involved in morphogenesis (GO:1902337)4.53653207
43sperm capacitation (GO:0048240)4.47640208
44platelet dense granule organization (GO:0060155)4.45308609
45peptidyl-threonine dephosphorylation (GO:0035970)4.43984819
46positive regulation of glycoprotein biosynthetic process (GO:0010560)4.35931376
47multicellular organismal water homeostasis (GO:0050891)4.32324948
48axoneme assembly (GO:0035082)4.31996261
49regulation of guanylate cyclase activity (GO:0031282)4.30007566
50response to interferon-alpha (GO:0035455)4.26268489
51negative regulation of erythrocyte differentiation (GO:0045647)4.26072500
52respiratory chain complex IV assembly (GO:0008535)4.15508973
53viral life cycle (GO:0019058)4.13632395
54oligosaccharide biosynthetic process (GO:0009312)4.06096574
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.04271193
56urogenital system development (GO:0001655)3.99771716
57cellular protein complex disassembly (GO:0043624)3.99409820
58maturation of SSU-rRNA (GO:0030490)3.95515220
59regulation of type B pancreatic cell apoptotic process (GO:2000674)3.88898834
60cellular glucuronidation (GO:0052695)3.88030953
61translational initiation (GO:0006413)3.86830995
62positive regulation of protein export from nucleus (GO:0046827)3.85941227
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.84500499
64antigen processing and presentation via MHC class Ib (GO:0002475)3.83227036
65generation of neurons (GO:0048699)3.81075569
66NADH metabolic process (GO:0006734)3.80182747
67glucuronate metabolic process (GO:0019585)3.79525738
68uronic acid metabolic process (GO:0006063)3.79525738
69flavonoid metabolic process (GO:0009812)3.79499037
70mannosylation (GO:0097502)3.78201272
71mesonephros development (GO:0001823)3.78158864
72exogenous drug catabolic process (GO:0042738)3.77260886
73DNA strand elongation involved in DNA replication (GO:0006271)3.77010408
74positive regulation of hormone metabolic process (GO:0032352)3.76258669
75negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.74823289
76telomere maintenance via recombination (GO:0000722)3.74290889
77fucose catabolic process (GO:0019317)3.68780981
78L-fucose metabolic process (GO:0042354)3.68780981
79L-fucose catabolic process (GO:0042355)3.68780981
80negative regulation of T cell differentiation in thymus (GO:0033085)3.66765056
81water homeostasis (GO:0030104)3.66722181
82primary alcohol metabolic process (GO:0034308)3.66172324
83excretion (GO:0007588)3.65489540
84drug metabolic process (GO:0017144)3.63212854
85DNA strand elongation (GO:0022616)3.60434886
86sodium ion homeostasis (GO:0055078)3.58716482
87response to interferon-beta (GO:0035456)3.57939199
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56210430
89endosome to melanosome transport (GO:0035646)3.55406832
90endosome to pigment granule transport (GO:0043485)3.55406832
91citrulline biosynthetic process (GO:0019240)3.54523701
92protein complex disassembly (GO:0043241)3.52222298
93renal system process involved in regulation of blood volume (GO:0001977)3.52213099
94intestinal epithelial cell development (GO:0060576)3.52138475
95DNA replication initiation (GO:0006270)3.50515947
96glutathione biosynthetic process (GO:0006750)3.48037772
97epithelial cell-cell adhesion (GO:0090136)3.45457159
98drug catabolic process (GO:0042737)3.43723049
99left/right pattern formation (GO:0060972)3.43462942
100positive regulation of metanephros development (GO:0072216)3.43333124
101metanephric nephron tubule development (GO:0072234)3.41900128
102metanephric tubule development (GO:0072170)3.41900128
103antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41540518
104antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41540518
105urea cycle (GO:0000050)3.40376370
106regulation of female gonad development (GO:2000194)3.39511739
107sphingomyelin metabolic process (GO:0006684)3.39377805
108definitive hemopoiesis (GO:0060216)3.38018146
109regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.35592899
110endocrine process (GO:0050886)3.35592899
111regulation of systemic arterial blood pressure by hormone (GO:0001990)3.35592899
112positive regulation of Cdc42 GTPase activity (GO:0043089)3.35314653
113genitalia morphogenesis (GO:0035112)3.34041447
114nonribosomal peptide biosynthetic process (GO:0019184)3.33366458
115macromolecular complex disassembly (GO:0032984)3.32014575
116oocyte development (GO:0048599)3.31586937
117maintenance of gastrointestinal epithelium (GO:0030277)3.27103093
118GPI anchor biosynthetic process (GO:0006506)3.26643537
119positive regulation of glycoprotein metabolic process (GO:1903020)3.26499770
120negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.23988082
121protein targeting to membrane (GO:0006612)3.21821512
122pseudouridine synthesis (GO:0001522)3.20529894
123urea metabolic process (GO:0019627)3.20051099
124facial nerve structural organization (GO:0021612)3.19336894
125fat-soluble vitamin biosynthetic process (GO:0042362)3.17344777
126lung epithelium development (GO:0060428)3.16045181
127mitotic recombination (GO:0006312)3.13633310
128bile acid and bile salt transport (GO:0015721)3.13546847
129mature B cell differentiation involved in immune response (GO:0002313)3.13243064
130citrulline metabolic process (GO:0000052)3.12913443
131ribosomal large subunit biogenesis (GO:0042273)3.11751785
132C-terminal protein lipidation (GO:0006501)3.09868800
133regulation of cholesterol homeostasis (GO:2000188)3.09512615
134cytochrome complex assembly (GO:0017004)3.07894986
135thyroid gland development (GO:0030878)3.07233618
136nuclear-transcribed mRNA catabolic process (GO:0000956)3.05363683
137regulation of hormone metabolic process (GO:0032350)3.04024464
138retinol metabolic process (GO:0042572)3.02470243
139sulfur compound transport (GO:0072348)3.02456381
140positive regulation of pseudopodium assembly (GO:0031274)2.99787530
141dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.98881057
142translation (GO:0006412)2.98858559
143metanephric nephron epithelium development (GO:0072243)2.98762790
144retinoic acid metabolic process (GO:0042573)2.98638625
145vitamin transport (GO:0051180)2.98118413
146positive regulation of triglyceride biosynthetic process (GO:0010867)2.97957843
147establishment or maintenance of bipolar cell polarity (GO:0061245)2.97375709
148establishment or maintenance of apical/basal cell polarity (GO:0035088)2.97375709
149mesenchymal to epithelial transition (GO:0060231)2.97277723
150telomere maintenance via telomere lengthening (GO:0010833)2.97235636
151protein O-linked glycosylation (GO:0006493)2.97144514
152renal absorption (GO:0070293)2.97031041
153positive regulation of gluconeogenesis (GO:0045722)2.96832433
154mast cell activation (GO:0045576)2.96765810
155one-carbon compound transport (GO:0019755)2.95629308
156regulation of systemic arterial blood pressure (GO:0003073)2.93834933
157positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93784006
158terpenoid biosynthetic process (GO:0016114)2.93696085
159protein kinase C signaling (GO:0070528)2.93586069
160hormone catabolic process (GO:0042447)2.92419680
161regulation of stem cell maintenance (GO:2000036)2.92037324
162mRNA catabolic process (GO:0006402)2.91971082
163glutathione derivative metabolic process (GO:1901685)2.91877369
164glutathione derivative biosynthetic process (GO:1901687)2.91877369
165glutathione metabolic process (GO:0006749)2.91181092
166phospholipid scrambling (GO:0017121)2.91105834
167receptor guanylyl cyclase signaling pathway (GO:0007168)2.90762417
168nitrogen cycle metabolic process (GO:0071941)2.90746857
169positive regulation of guanylate cyclase activity (GO:0031284)2.89440910
170defense response to protozoan (GO:0042832)2.89230944
171establishment of apical/basal cell polarity (GO:0035089)2.88180022
172positive regulation of B cell differentiation (GO:0045579)2.88132472
173regulation of bile acid biosynthetic process (GO:0070857)2.87891369
174metanephric epithelium development (GO:0072207)2.86585576
175ribonucleoprotein complex biogenesis (GO:0022613)2.83874708
176diacylglycerol metabolic process (GO:0046339)2.82583301
177regulation of mesenchymal cell apoptotic process (GO:2001053)2.80769958
178amyloid precursor protein catabolic process (GO:0042987)2.80533917
179positive regulation of respiratory burst (GO:0060267)2.80417831
180labyrinthine layer development (GO:0060711)2.80107446
181negative regulation of kidney development (GO:0090185)2.79288722
182RNA catabolic process (GO:0006401)2.78603936
183megakaryocyte development (GO:0035855)2.78381341
184regulation of T cell mediated cytotoxicity (GO:0001914)2.78240227
185signal peptide processing (GO:0006465)2.77069266
186sulfate transmembrane transport (GO:1902358)2.76582908
187very long-chain fatty acid metabolic process (GO:0000038)2.76017431
188cellular response to pH (GO:0071467)2.73890115
189drug transport (GO:0015893)2.73795641
190regulation of cholesterol metabolic process (GO:0090181)2.73787645
191left/right axis specification (GO:0070986)2.72969394
192polyketide metabolic process (GO:0030638)2.71399699
193doxorubicin metabolic process (GO:0044598)2.71399699
194daunorubicin metabolic process (GO:0044597)2.71399699
195auditory receptor cell differentiation (GO:0042491)2.68363470
196regulation of water loss via skin (GO:0033561)2.66886987
197progesterone metabolic process (GO:0042448)2.64724470
198lipoprotein transport (GO:0042953)2.64313320
199axonemal dynein complex assembly (GO:0070286)10.1566947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.82608008
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.26850827
3E2F7_22180533_ChIP-Seq_HELA_Human4.24537094
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.94450243
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.79438428
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.78098261
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.51080373
8SCL_19346495_ChIP-Seq_HPC-7_Human3.50413823
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.33293525
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.30888769
11ESR2_21235772_ChIP-Seq_MCF-7_Human3.23432216
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.20115565
13SOX2_27498859_Chip-Seq_STOMACH_Mouse3.13313513
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01854618
15ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00646065
16TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.99668796
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96950345
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91876303
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.89237180
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.85192252
21GATA1_22025678_ChIP-Seq_K562_Human2.84717519
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.76938769
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.74035348
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.73515520
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69195606
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59118228
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.56942172
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54707345
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54064492
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.52300152
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.50371674
32ERG_20887958_ChIP-Seq_HPC-7_Mouse2.47313800
33TRIM28_21343339_ChIP-Seq_HEK293_Human2.44904256
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.44228054
35SOX2_20726797_ChIP-Seq_SW620_Human2.41140268
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39003681
37GATA4_25053715_ChIP-Seq_YYC3_Human2.37651028
38MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36382624
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.31687023
40GATA6_25053715_ChIP-Seq_YYC3_Human2.31531734
41ETS1_20019798_ChIP-Seq_JURKAT_Human2.31234788
42RACK7_27058665_Chip-Seq_MCF-7_Human2.25258542
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.14591727
44RXR_22158963_ChIP-Seq_LIVER_Mouse2.14546921
45* RUNX1_27514584_Chip-Seq_MCF-7_Human2.13136679
46VDR_23849224_ChIP-Seq_CD4+_Human2.12886017
47FOXO3_23340844_ChIP-Seq_DLD1_Human2.10076985
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07006677
49HOXB4_20404135_ChIP-ChIP_EML_Mouse2.06388060
50* SPI1_23547873_ChIP-Seq_NB4_Human2.04273671
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.03861227
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.01054681
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99483513
54ZNF263_19887448_ChIP-Seq_K562_Human1.98677826
55VDR_21846776_ChIP-Seq_THP-1_Human1.98097762
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91710189
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.91037220
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.85021486
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84717345
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84668218
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.83203712
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.82850849
63FOXP3_21729870_ChIP-Seq_TREG_Human1.82316752
64DROSHA_22980978_ChIP-Seq_HELA_Human1.81884483
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81539720
66* KLF5_25053715_ChIP-Seq_YYC3_Human1.80583639
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80052297
68MYC_22102868_ChIP-Seq_BL_Human1.78380222
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78327946
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77762556
71FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.77466187
72LXR_22158963_ChIP-Seq_LIVER_Mouse1.77177382
73LXR_22292898_ChIP-Seq_THP-1_Human1.76610143
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.76069487
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74565360
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74440653
77XRN2_22483619_ChIP-Seq_HELA_Human1.71338190
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68755761
79CIITA_25753668_ChIP-Seq_RAJI_Human1.67430583
80* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67337014
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67150364
82VDR_24763502_ChIP-Seq_THP-1_Human1.65701936
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.64775748
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63477643
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62330185
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.62055628
87* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59537656
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.56784641
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54945574
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54692032
91GATA3_24758297_ChIP-Seq_MCF-7_Human1.54484714
92* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52896017
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51757741
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51714291
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50765118
96DCP1A_22483619_ChIP-Seq_HELA_Human1.50507684
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.48260169
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46068332
99TP63_22573176_ChIP-Seq_HFKS_Human1.46041437
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45467193
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44479170
102MYB_26560356_Chip-Seq_TH2_Human1.43980550
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43632792
104IRF8_21731497_ChIP-ChIP_J774_Mouse1.40687004
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39781397
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39339457
107CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39238121
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38669454
109AHR_22903824_ChIP-Seq_MCF-7_Human1.38554661
110RAD21_21589869_ChIP-Seq_MESCs_Mouse1.37780218
111TTF2_22483619_ChIP-Seq_HELA_Human1.37713707
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37398650
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37366939
114* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36314563
115GABP_19822575_ChIP-Seq_HepG2_Human1.35999232
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34670517
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34186261
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34070461
119FOXA1_25552417_ChIP-Seq_VCAP_Human1.33842266
120SMC4_20622854_ChIP-Seq_HELA_Human1.33772477
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33116600
122P68_20966046_ChIP-Seq_HELA_Human1.31935243
123EZH2_22144423_ChIP-Seq_EOC_Human1.30404416
124MYB_26560356_Chip-Seq_TH1_Human1.29571031
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28572534
126STAT1_20625510_ChIP-Seq_HELA_Human1.26886556
127ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26515647
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25701542
129FOXA2_19822575_ChIP-Seq_HepG2_Human1.25531061
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25422294
131CREB1_26743006_Chip-Seq_LNCaP_Human1.24752977
132ELK1_19687146_ChIP-ChIP_HELA_Human1.24415593
133BCOR_27268052_Chip-Seq_Bcells_Human1.24175330
134EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24079564
135* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23786042
136MAF_26560356_Chip-Seq_TH1_Human1.23262105
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.23046811
138SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22778166
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21342239
140CLOCK_20551151_ChIP-Seq_293T_Human1.17618196
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16386789
142CTCF_27219007_Chip-Seq_Bcells_Human1.16096999
143PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15720142
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14129579
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13478828
146PHF8_20622854_ChIP-Seq_HELA_Human1.11940228
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10360285
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09874014
149ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09561419
150BCL6_27268052_Chip-Seq_Bcells_Human1.09015323
151GATA1_19941827_ChIP-Seq_MEL_Mouse1.08883022
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08631337
153* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08077823
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07814967
155BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07567735
156MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06981135
157HNF4A_19822575_ChIP-Seq_HepG2_Human1.06642680
158UTX_26944678_Chip-Seq_JUKART_Human1.04538944
159CTCF_20526341_ChIP-Seq_ESCs_Human1.04465160
160TET1_21451524_ChIP-Seq_MESCs_Mouse1.04460465
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04360538
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03717637
163GATA1_19941826_ChIP-Seq_K562_Human1.03301406
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02989849
165MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02336627
166ERG_21242973_ChIP-ChIP_JURKAT_Human1.00673509
167IRF8_27001747_Chip-Seq_BMDM_Mouse1.00511871
168ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97756607
169MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97708536
170P300_27268052_Chip-Seq_Bcells_Human0.96624367
171FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95724912
172E2F1_20622854_ChIP-Seq_HELA_Human0.95490760
173TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95412851
174PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95017107
175NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93810563
176CEBPB_22108803_ChIP-Seq_LS180_Human0.93631590
177E2F1_21310950_ChIP-Seq_MCF-7_Human0.92973207
178JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92858367
179AR_21909140_ChIP-Seq_LNCAP_Human0.92621357
180FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92575904
181MYC_18940864_ChIP-ChIP_HL60_Human0.92456856
182TCF7_22412390_ChIP-Seq_EML_Mouse0.91366815
183E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90429114
184SA1_27219007_Chip-Seq_ERYTHROID_Human0.90424301
185MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90404190
186CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89324370
187STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88799293
188POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88799206
189P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88454618
190CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88418151
191YY1_22570637_ChIP-Seq_MALME-3M_Human0.88056378
192SA1_27219007_Chip-Seq_Bcells_Human0.87935817
193EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87801878
194CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87463293
195SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86998334
196SPI1_23127762_ChIP-Seq_K562_Human0.86569255
197ATF3_27146783_Chip-Seq_COLON_Human0.85984746
198UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85415134
199TP63_23658742_ChIP-Seq_EP156T_Human0.85252595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.76656904
2MP0002139_abnormal_hepatobiliary_system5.47097610
3MP0009379_abnormal_foot_pigmentation4.90546396
4MP0005360_urolithiasis4.46181183
5MP0005174_abnormal_tail_pigmentation3.92902130
6MP0002396_abnormal_hematopoietic_system3.91274163
7MP0004264_abnormal_extraembryonic_tissu3.70426246
8MP0008875_abnormal_xenobiotic_pharmacok3.56774259
9MP0005085_abnormal_gallbladder_physiolo3.39059011
10MP0001666_abnormal_nutrient_absorption3.22017488
11MP0000490_abnormal_crypts_of2.93816676
12MP0001188_hyperpigmentation2.93111802
13MP0001835_abnormal_antigen_presentation2.87501026
14MP0004147_increased_porphyrin_level2.86986030
15MP0004043_abnormal_pH_regulation2.85854971
16MP0005075_abnormal_melanosome_morpholog2.83873103
17MP0004019_abnormal_vitamin_homeostasis2.83647354
18MP0005409_darkened_coat_color2.69944275
19MP0003718_maternal_effect2.67416529
20MP0009785_altered_susceptibility_to2.63694627
21MP0005365_abnormal_bile_salt2.63687621
22MP0000566_synostosis2.61229718
23MP0003183_abnormal_peptide_metabolism2.60880018
24MP0000685_abnormal_immune_system2.59583490
25MP0003724_increased_susceptibility_to2.52757013
26MP0010352_gastrointestinal_tract_polyps2.49997672
27MP0003868_abnormal_feces_composition2.47225656
28MP0005671_abnormal_response_to2.46142198
29MP0003879_abnormal_hair_cell2.40536551
30MP0001545_abnormal_hematopoietic_system2.33051251
31MP0005397_hematopoietic_system_phenotyp2.33051251
32MP0003646_muscle_fatigue2.28667320
33MP0001664_abnormal_digestion2.28531304
34MP0000681_abnormal_thyroid_gland2.27941509
35MP0002095_abnormal_skin_pigmentation2.27532700
36MP0002796_impaired_skin_barrier2.24602936
37MP0006292_abnormal_olfactory_placode2.13602122
38MP0001765_abnormal_ion_homeostasis2.10646993
39MP0000015_abnormal_ear_pigmentation2.09890269
40MP0000465_gastrointestinal_hemorrhage2.09062419
41MP0010678_abnormal_skin_adnexa2.05915903
42MP0005025_abnormal_response_to2.01784815
43MP0009780_abnormal_chondrocyte_physiolo1.98698973
44MP0003763_abnormal_thymus_physiology1.98215793
45MP0002148_abnormal_hypersensitivity_rea1.93380116
46MP0009840_abnormal_foam_cell1.92544387
47MP0002098_abnormal_vibrissa_morphology1.91303399
48MP0004808_abnormal_hematopoietic_stem1.90325608
49MP0002398_abnormal_bone_marrow1.80719659
50MP0001873_stomach_inflammation1.74859581
51MP0010155_abnormal_intestine_physiology1.73964341
52MP0008007_abnormal_cellular_replicative1.69386054
53MP0001986_abnormal_taste_sensitivity1.69167838
54MP0005000_abnormal_immune_tolerance1.68235513
55MP0009333_abnormal_splenocyte_physiolog1.65277893
56MP0005464_abnormal_platelet_physiology1.65146168
57MP0000689_abnormal_spleen_morphology1.64397311
58MP0001800_abnormal_humoral_immune1.64353372
59MP0002420_abnormal_adaptive_immunity1.62437106
60MP0003436_decreased_susceptibility_to1.62129359
61MP0002723_abnormal_immune_serum1.62049385
62MP0001819_abnormal_immune_cell1.60113554
63MP0003693_abnormal_embryo_hatching1.60041948
64MP0001853_heart_inflammation1.59703649
65MP0005395_other_phenotype1.54614394
66MP0002452_abnormal_antigen_presenting1.51834032
67MP0003866_abnormal_defecation1.51486676
68MP0002166_altered_tumor_susceptibility1.51175722
69MP0000716_abnormal_immune_system1.51084243
70MP0000383_abnormal_hair_follicle1.49408407
71MP0002722_abnormal_immune_system1.48985255
72MP0002419_abnormal_innate_immunity1.48859616
73MP0009643_abnormal_urine_homeostasis1.47673358
74MP0005501_abnormal_skin_physiology1.43640334
75MP0002429_abnormal_blood_cell1.40664760
76MP0002653_abnormal_ependyma_morphology1.38460467
77MP0008789_abnormal_olfactory_epithelium1.36636009
78MP0008058_abnormal_DNA_repair1.34113804
79MP0003656_abnormal_erythrocyte_physiolo1.34006551
80MP0004782_abnormal_surfactant_physiolog1.31148772
81MP0000372_irregular_coat_pigmentation1.29139809
82MP0006054_spinal_hemorrhage1.26357121
83MP0002277_abnormal_respiratory_mucosa1.24650781
84MP0010094_abnormal_chromosome_stability1.23306831
85MP0006036_abnormal_mitochondrial_physio1.22120479
86MP0003806_abnormal_nucleotide_metabolis1.18797965
87MP0002006_tumorigenesis1.16973347
88MP0000462_abnormal_digestive_system1.13427780
89MP0002136_abnormal_kidney_physiology1.13112421
90MP0001845_abnormal_inflammatory_respons1.12917262
91MP0003453_abnormal_keratinocyte_physiol1.11949533
92MP0002876_abnormal_thyroid_physiology1.11487699
93MP0003252_abnormal_bile_duct1.10686697
94MP0003191_abnormal_cellular_cholesterol1.10232532
95MP0002138_abnormal_hepatobiliary_system1.08990564
96MP0005387_immune_system_phenotype1.08717719
97MP0001790_abnormal_immune_system1.08717719
98MP0008469_abnormal_protein_level1.06866303
99MP0010329_abnormal_lipoprotein_level1.06662519
100MP0000537_abnormal_urethra_morphology1.03732595
101MP0003283_abnormal_digestive_organ1.03197953
102MP0002177_abnormal_outer_ear1.02557282
103MP0000467_abnormal_esophagus_morphology1.02222141
104MP0002019_abnormal_tumor_incidence1.01802145
105MP0002132_abnormal_respiratory_system1.00925957
106MP0000049_abnormal_middle_ear1.00554249
107MP0003959_abnormal_lean_body0.99245320
108MP0004130_abnormal_muscle_cell0.98854521
109MP0000631_abnormal_neuroendocrine_gland0.97563418
110MP0001849_ear_inflammation0.96439615
111MP0005332_abnormal_amino_acid0.94812916
112MP0005381_digestive/alimentary_phenotyp0.94541124
113MP0002405_respiratory_system_inflammati0.94396481
114MP0000703_abnormal_thymus_morphology0.94010339
115MP0004957_abnormal_blastocyst_morpholog0.93628227
116MP0003303_peritoneal_inflammation0.92070400
117MP0001663_abnormal_digestive_system0.91903547
118MP0000477_abnormal_intestine_morphology0.91805404
119MP0005023_abnormal_wound_healing0.91269995
120MP0004381_abnormal_hair_follicle0.90152991
121MP0003828_pulmonary_edema0.89682839
122MP0002249_abnormal_larynx_morphology0.88686636
123MP0005394_taste/olfaction_phenotype0.88150793
124MP0005499_abnormal_olfactory_system0.88150793
125MP0005166_decreased_susceptibility_to0.87476317
126MP0002938_white_spotting0.85752372
127MP0005083_abnormal_biliary_tract0.85349508
128MP0002896_abnormal_bone_mineralization0.85321739
129MP0001756_abnormal_urination0.84376530
130MP0005670_abnormal_white_adipose0.84275009
131MP0008057_abnormal_DNA_replication0.82495838
132MP0000343_altered_response_to0.81798532
133MP0005319_abnormal_enzyme/_coenzyme0.81564020
134MP0005266_abnormal_metabolism0.81035780
135MP0003186_abnormal_redox_activity0.80890602
136MP0005165_increased_susceptibility_to0.80844909
137MP0003077_abnormal_cell_cycle0.80569284
138MP0002118_abnormal_lipid_homeostasis0.79988941
139MP0002160_abnormal_reproductive_system0.79599068
140MP0001216_abnormal_epidermal_layer0.78485612
141MP0005584_abnormal_enzyme/coenzyme_acti0.77115933
142MP0002075_abnormal_coat/hair_pigmentati0.76892092
143MP0005076_abnormal_cell_differentiation0.76543337
144MP0003938_abnormal_ear_development0.75967169
145MP0003786_premature_aging0.74808101
146MP0002822_catalepsy0.74304472
147MP0001881_abnormal_mammary_gland0.73763106
148MP0003705_abnormal_hypodermis_morpholog0.72752738
149MP0000377_abnormal_hair_follicle0.72282060
150MP0008569_lethality_at_weaning0.71870536
151MP0002933_joint_inflammation0.71030513
152MP0002168_other_aberrant_phenotype0.69554728
153MP0000762_abnormal_tongue_morphology0.69516952
154MP0001348_abnormal_lacrimal_gland0.69398791
155MP0001764_abnormal_homeostasis0.69042975
156MP0008004_abnormal_stomach_pH0.68574038
157MP0005451_abnormal_body_composition0.67180908
158MP0000538_abnormal_urinary_bladder0.67049665
159MP0000470_abnormal_stomach_morphology0.65590418
160MP0003136_yellow_coat_color0.64713429
161MP0000609_abnormal_liver_physiology0.64147761
162MP0000678_abnormal_parathyroid_gland0.64123243
163MP0009764_decreased_sensitivity_to0.63942364
164MP0008872_abnormal_physiological_respon0.63757219
165MP0002909_abnormal_adrenal_gland0.63000921
166MP0002089_abnormal_postnatal_growth/wei0.62663056
167MP0000313_abnormal_cell_death0.61553447
168MP0003941_abnormal_skin_development0.61439250
169MP0002638_abnormal_pupillary_reflex0.59851316
170MP0005636_abnormal_mineral_homeostasis0.59665278
171MP0000613_abnormal_salivary_gland0.58818486
172MP0000358_abnormal_cell_content/0.58431839
173MP0000627_abnormal_mammary_gland0.58423108
174MP0003699_abnormal_female_reproductive0.57849826
175MP0005058_abnormal_lysosome_morphology0.56533018
176MP0004133_heterotaxia0.55113518
177MP0005666_abnormal_adipose_tissue0.54838499
178MP0010030_abnormal_orbit_morphology0.52693098
179MP0010771_integument_phenotype0.52086820

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.90297440
2Reduced antithrombin III activity (HP:0001976)8.28352229
3Abnormal respiratory motile cilium physiology (HP:0012261)7.78164195
4Abnormal respiratory motile cilium morphology (HP:0005938)7.73606494
5Abnormal respiratory epithelium morphology (HP:0012253)7.73606494
6Abnormal ciliary motility (HP:0012262)7.55768149
7Dynein arm defect of respiratory motile cilia (HP:0012255)7.47623676
8Absent/shortened dynein arms (HP:0200106)7.47623676
9Rhinitis (HP:0012384)7.36108168
10Type I transferrin isoform profile (HP:0003642)7.19489128
11Hyperactive renin-angiotensin system (HP:0000841)7.08259159
12Chronic bronchitis (HP:0004469)6.93482903
13Hypothermia (HP:0002045)6.91122279
14Thyroid-stimulating hormone excess (HP:0002925)6.56721981
15Abnormal number of erythroid precursors (HP:0012131)5.65887405
16Abnormality of cells of the erythroid lineage (HP:0012130)5.63110673
17Bronchiectasis (HP:0002110)5.61158777
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)5.19663837
19Abnormal protein N-linked glycosylation (HP:0012347)5.19663837
20Abnormal protein glycosylation (HP:0012346)5.19663837
21Abnormal glycosylation (HP:0012345)5.19663837
22Decreased circulating renin level (HP:0003351)5.04007377
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16177380
24Abnormality of renin-angiotensin system (HP:0000847)4.13842393
25Male infertility (HP:0003251)4.12537187
26Thrombocytosis (HP:0001894)3.83703256
27Infertility (HP:0000789)3.81610563
28Malnutrition (HP:0004395)3.81066352
29Absent rod-and cone-mediated responses on ERG (HP:0007688)3.77954573
30Flat acetabular roof (HP:0003180)3.77608041
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76268319
32Prolonged partial thromboplastin time (HP:0003645)3.75707944
33Reticulocytopenia (HP:0001896)3.72988302
34Ankle contracture (HP:0006466)3.71440075
35Abnormality of the heme biosynthetic pathway (HP:0010472)3.54218938
36Bronchitis (HP:0012387)3.52816564
37Hyperaldosteronism (HP:0000859)3.52577306
38Elevated erythrocyte sedimentation rate (HP:0003565)3.46457028
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.43664231
40Severe visual impairment (HP:0001141)3.41015840
41IgM deficiency (HP:0002850)3.25695756
42Abnormality of chloride homeostasis (HP:0011422)3.24822609
43Aplastic anemia (HP:0001915)3.24359222
44Hepatocellular necrosis (HP:0001404)3.20147447
45Chronic otitis media (HP:0000389)3.15812203
46Petechiae (HP:0000967)3.15539167
47Increased hepatocellular lipid droplets (HP:0006565)3.15284062
48Type 2 muscle fiber atrophy (HP:0003554)3.14817758
49Muscle fiber atrophy (HP:0100295)3.12581862
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.09358477
51Cortical visual impairment (HP:0100704)3.08855332
52Pallor (HP:0000980)3.05694860
53Macrocytic anemia (HP:0001972)2.96203787
54Recurrent sinusitis (HP:0011108)2.92518936
55Flat occiput (HP:0005469)2.91475563
56Exertional dyspnea (HP:0002875)2.89274370
57Chronic sinusitis (HP:0011109)2.89126820
58Myositis (HP:0100614)2.85054972
59Lipid accumulation in hepatocytes (HP:0006561)2.83444572
60Hyponatremia (HP:0002902)2.83215110
61Hyperkalemia (HP:0002153)2.79615324
62Alkalosis (HP:0001948)2.78213421
63Hepatic necrosis (HP:0002605)2.77809771
64Increased intramyocellular lipid droplets (HP:0012240)2.76815378
65Renal Fanconi syndrome (HP:0001994)2.72474960
66Recurrent otitis media (HP:0000403)2.71138768
67Metabolic alkalosis (HP:0200114)2.69566051
68Lower limb hyperreflexia (HP:0002395)2.66137405
69Pili torti (HP:0003777)2.64630228
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.64528740
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.64528740
72Nonprogressive disorder (HP:0003680)2.63754610
73Prolonged bleeding time (HP:0003010)2.54938050
74Microcytic anemia (HP:0001935)2.52961992
75Right ventricular cardiomyopathy (HP:0011663)2.51810509
76Acute lymphatic leukemia (HP:0006721)2.48871204
77Increased muscle lipid content (HP:0009058)2.48838014
78Hydroxyprolinuria (HP:0003080)2.48552205
79Abnormality of proline metabolism (HP:0010907)2.48552205
80Spinal cord compression (HP:0002176)2.45657781
81Abnormality of carpal bone ossification (HP:0006257)2.40678675
82Fat malabsorption (HP:0002630)2.37608957
83Renal salt wasting (HP:0000127)2.36822141
84Abnormal rod and cone electroretinograms (HP:0008323)2.36433779
85Atelectasis (HP:0100750)2.35420838
86Hyperbilirubinemia (HP:0002904)2.30877639
87Abnormality of T cell physiology (HP:0011840)2.30175489
883-Methylglutaconic aciduria (HP:0003535)2.29813012
89Microvesicular hepatic steatosis (HP:0001414)2.28734328
90Epistaxis (HP:0000421)2.26070990
91Respiratory difficulties (HP:0002880)2.25318576
92Panhypogammaglobulinemia (HP:0003139)2.22065827
93Ileus (HP:0002595)2.21433498
94Thoracic kyphosis (HP:0002942)2.20191132
95Intrahepatic cholestasis (HP:0001406)2.19465243
96Adrenal overactivity (HP:0002717)2.17852520
97Acute myeloid leukemia (HP:0004808)2.13885830
98Hemorrhage of the eye (HP:0011885)2.13114073
99Recurrent bronchitis (HP:0002837)2.11641219
100Hyperpituitarism (HP:0010514)2.10906547
101Hypotension (HP:0002615)2.10390307
102Abnormality of sodium homeostasis (HP:0010931)2.08411223
103Abnormality of the distal phalanges of the toes (HP:0010182)2.07917720
104Recurrent abscess formation (HP:0002722)2.07912553
105Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07874924
106Abnormality of vitamin metabolism (HP:0100508)2.07565956
107Lip pit (HP:0100267)2.07079733
108Impaired platelet aggregation (HP:0003540)2.06851611
109Abnormal platelet function (HP:0011869)2.06851611
110Abdominal distention (HP:0003270)2.04897724
111Progressive muscle weakness (HP:0003323)2.04191578
112Abnormality of magnesium homeostasis (HP:0004921)2.02974936
113Abnormality of B cell number (HP:0010975)2.01849363
114B lymphocytopenia (HP:0010976)2.01849363
115Pancytopenia (HP:0001876)2.00532738
116Abnormal hair laboratory examination (HP:0003328)2.00513964
117Increased serum lactate (HP:0002151)1.98471316
118Cone-rod dystrophy (HP:0000548)1.98100216
119Abnormality of the prostate (HP:0008775)1.97752133
120Abnormality of alanine metabolism (HP:0010916)1.95798779
121Hyperalaninemia (HP:0003348)1.95798779
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95798779
123Mitochondrial inheritance (HP:0001427)1.94919015
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93286892
125Hypoproteinemia (HP:0003075)1.92237045
126Occipital encephalocele (HP:0002085)1.90810799
127Abnormality of the nasal mucosa (HP:0000433)1.90354235
128Pendular nystagmus (HP:0012043)1.89906169
129Attenuation of retinal blood vessels (HP:0007843)1.89480331
130Meningitis (HP:0001287)1.89297983
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.89156915
132Osteomalacia (HP:0002749)1.85163144
133Abnormal hand bone ossification (HP:0010660)1.83855012
134Recurrent bacterial skin infections (HP:0005406)1.83242093
135Erythema (HP:0010783)1.82938176
136Abnormality of potassium homeostasis (HP:0011042)1.82781396
137Congenital sensorineural hearing impairment (HP:0008527)1.81488303
138Amaurosis fugax (HP:0100576)1.81289485
139Abnormal ossification of hand bones (HP:0005921)1.80886215
140Gastrointestinal stroma tumor (HP:0100723)1.77758090
141Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.77492129
142Severe global developmental delay (HP:0011344)1.77455617
143Chronic diarrhea (HP:0002028)1.75221726
144Hypokalemia (HP:0002900)1.75202171
145Knee flexion contracture (HP:0006380)1.75127743
146Poikiloderma (HP:0001029)1.74635864
147Dehydration (HP:0001944)1.74545313
148Postnatal microcephaly (HP:0005484)1.74462158
149Increased CSF lactate (HP:0002490)1.74195975
150Abnormal spermatogenesis (HP:0008669)1.74113104
151Hyperphosphatemia (HP:0002905)1.73909225
152Bradycardia (HP:0001662)1.73725154
153Subcapsular cataract (HP:0000523)1.73663481
154Abnormality of vitamin B metabolism (HP:0004340)1.72807124
155Ragged-red muscle fibers (HP:0003200)1.72361564
156Widely patent fontanelles and sutures (HP:0004492)1.72356183
157Abnormal tarsal ossification (HP:0008369)1.71557582
158Oral leukoplakia (HP:0002745)1.71543529
159Agammaglobulinemia (HP:0004432)1.71312410
160IgG deficiency (HP:0004315)1.69617890
161Abnormality of small intestinal villus morphology (HP:0011472)1.69544965
162Villous atrophy (HP:0011473)1.69544965
163Recurrent viral infections (HP:0004429)1.67159552
164Thin bony cortex (HP:0002753)1.65563912
165Conjugated hyperbilirubinemia (HP:0002908)1.64347677
166Nasal polyposis (HP:0100582)1.63966248
167Increased purine levels (HP:0004368)1.63295665
168Hyperuricemia (HP:0002149)1.63295665
169Steatorrhea (HP:0002570)1.61545136
170True hermaphroditism (HP:0010459)1.61467938
171Cystic liver disease (HP:0006706)1.61068805
172Migraine (HP:0002076)1.60188415
173Obstructive sleep apnea (HP:0002870)1.60136421
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.60105901
175Posterior subcapsular cataract (HP:0007787)1.59639768
176Vascular calcification (HP:0004934)1.59509992
177Rickets (HP:0002748)1.58191911
178Tubulointerstitial nephritis (HP:0001970)1.58030752
179Beaking of vertebral bodies (HP:0004568)1.57983423
180Flattened epiphyses (HP:0003071)1.57862992
181Growth hormone excess (HP:0000845)1.56774726
182Upper limb amyotrophy (HP:0009129)1.55211109
183Distal upper limb amyotrophy (HP:0007149)1.55211109
184Focal segmental glomerulosclerosis (HP:0000097)1.53813896
185Abnormality of the distal phalanx of the thumb (HP:0009617)1.51379694
186Popliteal pterygium (HP:0009756)1.49531048
187Hyperparathyroidism (HP:0000843)1.49034141
188Abnormal vertebral ossification (HP:0100569)1.48388036
189Glomerulosclerosis (HP:0000096)1.47416862
190Bell-shaped thorax (HP:0001591)1.46962114
191Renal tubular acidosis (HP:0001947)1.46688920
192Aplasia/hypoplasia of the femur (HP:0005613)1.46258662
193Hand muscle atrophy (HP:0009130)1.46141770
194Severe short stature (HP:0003510)1.45661481
195Gout (HP:0001997)1.45297144
196Hyperammonemia (HP:0001987)1.43613687
197Progressive sensorineural hearing impairment (HP:0000408)1.42388665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.71763644
2MST1R5.35348522
3MAPK154.74007922
4NLK4.08806131
5MST43.49575930
6LMTK23.41882358
7EIF2AK33.20201383
8KIT3.02101460
9STK162.86800815
10RIPK12.82511182
11MET2.73290452
12STK242.55575526
13FLT32.30516329
14SMG12.24355573
15WEE12.15542675
16MUSK2.14591381
17CDK192.09894984
18NME22.07689034
19TNIK11.0077246
20TEC1.89609761
21TRIB31.88143193
22PIK3CA1.88107635
23CAMKK21.85240088
24PIM21.81840214
25MKNK21.63871045
26FES1.57472930
27TTK1.56182504
28MAP3K21.55702801
29TESK11.42820292
30NEK61.40500654
31ACVR1B1.40252095
32NME11.38521107
33MKNK11.38174097
34CSF1R1.37276402
35PRKCI1.35200664
36STK391.34465925
37PTK61.33193172
38MATK1.30029645
39BTK1.27496804
40CAMK11.25117317
41TGFBR11.21997174
42VRK11.21764486
43EPHB21.18986879
44BRSK21.18291416
45MAP2K21.14013319
46ARAF1.11493184
47MAP3K131.09518273
48DYRK31.08679775
49SCYL21.08086806
50PTK21.07237579
51TLK11.06492645
52MAP3K31.05187332
53EIF2AK21.03423969
54EPHB10.99821888
55MAP4K10.98815903
56MAP2K70.97867335
57TGFBR20.91649453
58MAP3K120.91184484
59TIE10.90909806
60MAP3K100.90593364
61BUB10.90530996
62IRAK40.90401601
63OXSR10.88281635
64SIK10.88243850
65MAPK40.82265680
66FGFR40.78171784
67MAPKAPK50.77520664
68FER0.77282064
69PDPK10.76555008
70MAP3K60.75719342
71MELK0.75571754
72BCKDK0.73005183
73RIPK40.71462464
74ICK0.71118076
75SYK0.71005830
76RPS6KB20.70214243
77TBK10.70205833
78ZAP700.70121628
79PBK0.69438667
80DMPK0.69114165
81TESK20.68601679
82IRAK30.67910776
83PRPF4B0.67858298
84MAP2K30.66808249
85YES10.66552377
86TYK20.66307362
87EEF2K0.66169558
88ERBB20.64761040
89ADRBK20.64380628
90KDR0.63536156
91EIF2AK10.63132286
92LYN0.62409393
93CDK80.62396197
94BLK0.62372689
95CDK70.61669974
96PRKG20.58469903
97CDK90.56107136
98PKN20.55077342
99CDC42BPA0.54223818
100RAF10.51483148
101TAOK10.50635083
102CLK10.50430755
103GRK60.50197622
104JAK30.49998538
105IKBKB0.49874952
106IKBKE0.49617439
107MAPKAPK30.49236330
108TAOK30.49193594
109LCK0.48848505
110CCNB10.48123524
111RPS6KA20.47162797
112CSK0.46194002
113PIM10.46169566
114AURKA0.44873059
115SRPK10.44653241
116KSR20.43757262
117PRKAA20.41649513
118TXK0.39667452
119STK380.39133260
120CDK120.38754821
121MAP3K80.38180867
122MAP3K90.37560642
123CDK40.35852155
124ABL20.35441231
125CAMKK10.34439369
126DAPK10.34011983
127MAPK110.32605199
128ILK0.32236593
129CAMK2G0.32067655
130LRRK20.31934450
131MAP3K110.31859791
132PAK40.31732697
133MAP2K10.31560403
134PDK10.31112844
135MAP3K70.30711412
136SRC0.30387603
137MYLK0.30034740
138CSNK2A20.29868724
139DDR20.29539772
140MAP2K60.29293235
141BRAF0.28468847
142PRKCZ0.28250733
143RET0.27325928
144AKT20.27095470
145PINK10.26947270
146PRKCA0.25984563
147CDC70.25651427
148HIPK20.24902570
149MAPK130.24555972
150BRSK10.24421402
151PRKCD0.24219413
152CSNK2A10.22881078
153ATR0.22488081
154BMPR1B0.22348924
155PASK0.20711386
156PAK10.19399112
157RPS6KA40.18383525
158ERN10.18217403
159CAMK2D0.17444776
160MTOR0.16859171
161MARK20.16494125
162DYRK1B0.15205207
163FGFR30.15110253
164STK30.14972956
165HCK0.13810489
166MAPKAPK20.13205965
167ITK0.12471306
168TAOK20.12281687
169ABL10.11982121
170CSNK1G30.10542174
171CSNK1G10.10506603
172MAPK30.10155790
173MAP3K10.09600333

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.33449776
2DNA replication_Homo sapiens_hsa030305.18287328
3Thyroid cancer_Homo sapiens_hsa052163.53509150
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.53109611
5Histidine metabolism_Homo sapiens_hsa003403.50503190
6Chemical carcinogenesis_Homo sapiens_hsa052043.17740559
7Mismatch repair_Homo sapiens_hsa034303.12498370
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.05582431
9Protein export_Homo sapiens_hsa030602.99111484
10Phenylalanine metabolism_Homo sapiens_hsa003602.79748379
11Fat digestion and absorption_Homo sapiens_hsa049752.63298835
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.60923805
13Base excision repair_Homo sapiens_hsa034102.56460447
14Sulfur metabolism_Homo sapiens_hsa009202.50963616
15Pyrimidine metabolism_Homo sapiens_hsa002402.47524209
16Homologous recombination_Homo sapiens_hsa034402.45706023
17Retinol metabolism_Homo sapiens_hsa008302.44578651
18N-Glycan biosynthesis_Homo sapiens_hsa005102.37450151
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30834787
20RNA polymerase_Homo sapiens_hsa030202.27567217
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26696876
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23686783
23Tyrosine metabolism_Homo sapiens_hsa003502.13574172
24Sulfur relay system_Homo sapiens_hsa041222.10267701
25Spliceosome_Homo sapiens_hsa030402.08329810
26Nucleotide excision repair_Homo sapiens_hsa034202.02090630
27Arginine biosynthesis_Homo sapiens_hsa002202.00738564
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99027369
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.97127275
30Mineral absorption_Homo sapiens_hsa049781.96391045
31Fructose and mannose metabolism_Homo sapiens_hsa000511.90355763
32Starch and sucrose metabolism_Homo sapiens_hsa005001.86155180
33Primary immunodeficiency_Homo sapiens_hsa053401.76275422
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.68961831
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.68014910
36Bile secretion_Homo sapiens_hsa049761.61608770
37Proteasome_Homo sapiens_hsa030501.61569055
38Fatty acid degradation_Homo sapiens_hsa000711.60539850
39Acute myeloid leukemia_Homo sapiens_hsa052211.58546385
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48941127
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48322776
42Folate biosynthesis_Homo sapiens_hsa007901.48101632
43Other glycan degradation_Homo sapiens_hsa005111.46512366
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46363197
45Linoleic acid metabolism_Homo sapiens_hsa005911.46092104
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44531339
47PPAR signaling pathway_Homo sapiens_hsa033201.42700972
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40608573
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39382741
50Protein digestion and absorption_Homo sapiens_hsa049741.34458463
51Purine metabolism_Homo sapiens_hsa002301.33206356
52Hematopoietic cell lineage_Homo sapiens_hsa046401.32292218
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26793016
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.25758322
55Herpes simplex infection_Homo sapiens_hsa051681.25367755
56Non-homologous end-joining_Homo sapiens_hsa034501.25217421
57Arginine and proline metabolism_Homo sapiens_hsa003301.22416351
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14632414
59Tight junction_Homo sapiens_hsa045301.11690997
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10626608
61beta-Alanine metabolism_Homo sapiens_hsa004101.09318732
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08727394
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08422799
64Leishmaniasis_Homo sapiens_hsa051401.06093550
65Measles_Homo sapiens_hsa051621.05928007
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05837978
67Fanconi anemia pathway_Homo sapiens_hsa034601.03388454
68Nitrogen metabolism_Homo sapiens_hsa009101.03166631
69One carbon pool by folate_Homo sapiens_hsa006700.99898418
70p53 signaling pathway_Homo sapiens_hsa041150.97613490
71RNA degradation_Homo sapiens_hsa030180.96606917
72Pentose phosphate pathway_Homo sapiens_hsa000300.95227719
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94517470
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92378673
75B cell receptor signaling pathway_Homo sapiens_hsa046620.87129109
76Basal transcription factors_Homo sapiens_hsa030220.86657098
77Cell cycle_Homo sapiens_hsa041100.86155794
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.85169559
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.83171085
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82935199
81Antigen processing and presentation_Homo sapiens_hsa046120.82213680
82Glycerolipid metabolism_Homo sapiens_hsa005610.81778350
83Peroxisome_Homo sapiens_hsa041460.80393541
84Systemic lupus erythematosus_Homo sapiens_hsa053220.79129054
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75600357
86Pancreatic secretion_Homo sapiens_hsa049720.75363207
87Tryptophan metabolism_Homo sapiens_hsa003800.72966067
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72485367
89Allograft rejection_Homo sapiens_hsa053300.71959112
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71930259
91Ovarian steroidogenesis_Homo sapiens_hsa049130.71771590
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.70989132
93RNA transport_Homo sapiens_hsa030130.70317664
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66306097
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.63317893
96Caffeine metabolism_Homo sapiens_hsa002320.62225458
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61337844
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.61022483
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.60372895
100Hepatitis C_Homo sapiens_hsa051600.60220089
101Malaria_Homo sapiens_hsa051440.57969259
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56723737
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56419853
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55642090
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53998780
106Asthma_Homo sapiens_hsa053100.53386124
107Pertussis_Homo sapiens_hsa051330.52451660
108Legionellosis_Homo sapiens_hsa051340.51087910
109Influenza A_Homo sapiens_hsa051640.49718792
110Shigellosis_Homo sapiens_hsa051310.48862471
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.48816509
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47808111
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47055778
114ABC transporters_Homo sapiens_hsa020100.44855331
115Insulin resistance_Homo sapiens_hsa049310.43601534
116Osteoclast differentiation_Homo sapiens_hsa043800.43594584
117Parkinsons disease_Homo sapiens_hsa050120.43480983
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42295812
119Hepatitis B_Homo sapiens_hsa051610.41460112
120Pyruvate metabolism_Homo sapiens_hsa006200.41224878
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41076927
122Colorectal cancer_Homo sapiens_hsa052100.40999359
123Metabolic pathways_Homo sapiens_hsa011000.40514865
124Platelet activation_Homo sapiens_hsa046110.40497218
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.37829811
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37332099
127Epstein-Barr virus infection_Homo sapiens_hsa051690.36846436
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33911519
129Oxidative phosphorylation_Homo sapiens_hsa001900.33776524
130Adherens junction_Homo sapiens_hsa045200.29573781
131Arachidonic acid metabolism_Homo sapiens_hsa005900.29049357
132Galactose metabolism_Homo sapiens_hsa000520.28568053
133Fatty acid metabolism_Homo sapiens_hsa012120.28523423
134Ether lipid metabolism_Homo sapiens_hsa005650.27285796
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26806510
136Glutathione metabolism_Homo sapiens_hsa004800.26803458
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26216750
138Regulation of autophagy_Homo sapiens_hsa041400.26068324
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.25752375
140Alcoholism_Homo sapiens_hsa050340.25220651
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24458770
142Toxoplasmosis_Homo sapiens_hsa051450.24282835
143Biosynthesis of amino acids_Homo sapiens_hsa012300.23498253
144Notch signaling pathway_Homo sapiens_hsa043300.23147861
145Carbon metabolism_Homo sapiens_hsa012000.23071838
146Thyroid hormone synthesis_Homo sapiens_hsa049180.23047875
147Renin-angiotensin system_Homo sapiens_hsa046140.22787291
148Tuberculosis_Homo sapiens_hsa051520.22564521
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.21388501
150Salmonella infection_Homo sapiens_hsa051320.21243746
151Apoptosis_Homo sapiens_hsa042100.19440533
152Complement and coagulation cascades_Homo sapiens_hsa046100.18019240
153Vibrio cholerae infection_Homo sapiens_hsa051100.17071536
154Fatty acid elongation_Homo sapiens_hsa000620.16511876
155Huntingtons disease_Homo sapiens_hsa050160.16492972
156African trypanosomiasis_Homo sapiens_hsa051430.16006618
157Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14371814
158Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14083150
159Sphingolipid metabolism_Homo sapiens_hsa006000.12939762
160Choline metabolism in cancer_Homo sapiens_hsa052310.12903935
161Amoebiasis_Homo sapiens_hsa051460.12280556
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11837176
163Vitamin digestion and absorption_Homo sapiens_hsa049770.11468618
164Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09693995
165Fatty acid biosynthesis_Homo sapiens_hsa000610.06711430
166Butanoate metabolism_Homo sapiens_hsa006500.06496870
167Phosphatidylinositol signaling system_Homo sapiens_hsa040700.05016902
168Inositol phosphate metabolism_Homo sapiens_hsa005620.04119172
169AMPK signaling pathway_Homo sapiens_hsa041520.03971726
170Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02156960
171TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0219688
172Gap junction_Homo sapiens_hsa04540-0.0065581
173Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0056654

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