PRR16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.58556687
2L-phenylalanine catabolic process (GO:0006559)7.58556687
3L-phenylalanine metabolic process (GO:0006558)7.21018905
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21018905
5protein heterotrimerization (GO:0070208)6.99598079
6aromatic amino acid family catabolic process (GO:0009074)6.78599411
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.17006274
8tryptophan catabolic process (GO:0006569)6.13109447
9indole-containing compound catabolic process (GO:0042436)6.13109447
10indolalkylamine catabolic process (GO:0046218)6.13109447
11kynurenine metabolic process (GO:0070189)6.04175525
12bile acid biosynthetic process (GO:0006699)5.98631792
13tryptophan metabolic process (GO:0006568)5.74353029
14urea metabolic process (GO:0019627)5.61904022
15urea cycle (GO:0000050)5.61904022
16alpha-linolenic acid metabolic process (GO:0036109)5.60225930
17glyoxylate metabolic process (GO:0046487)5.59117763
18negative regulation of fibrinolysis (GO:0051918)5.56873372
19complement activation, alternative pathway (GO:0006957)5.46015606
20regulation of protein activation cascade (GO:2000257)5.39316706
21regulation of fibrinolysis (GO:0051917)5.39146909
22protein carboxylation (GO:0018214)5.38498683
23peptidyl-glutamic acid carboxylation (GO:0017187)5.38498683
24high-density lipoprotein particle remodeling (GO:0034375)5.38192936
25cysteine metabolic process (GO:0006534)5.28158251
26sulfur amino acid catabolic process (GO:0000098)5.26037921
27collagen fibril organization (GO:0030199)5.19697738
28nitrogen cycle metabolic process (GO:0071941)5.15400726
29bile acid metabolic process (GO:0008206)5.11863064
30regulation of complement activation (GO:0030449)5.05041011
31serine family amino acid catabolic process (GO:0009071)4.98082880
32aromatic amino acid family metabolic process (GO:0009072)4.88859379
33arginine catabolic process (GO:0006527)4.84847600
34tyrosine metabolic process (GO:0006570)4.78733851
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78631150
36sequestering of extracellular ligand from receptor (GO:0035581)4.76911792
37homocysteine metabolic process (GO:0050667)4.71846166
38regulation of triglyceride catabolic process (GO:0010896)4.70757816
39reverse cholesterol transport (GO:0043691)4.66983464
40regulation of cholesterol esterification (GO:0010872)4.64592683
41plasma lipoprotein particle remodeling (GO:0034369)4.59788854
42protein-lipid complex remodeling (GO:0034368)4.59788854
43macromolecular complex remodeling (GO:0034367)4.59788854
44triglyceride homeostasis (GO:0070328)4.57721023
45acylglycerol homeostasis (GO:0055090)4.57721023
46alpha-amino acid catabolic process (GO:1901606)4.57431311
47amino-acid betaine metabolic process (GO:0006577)4.55741726
48lysine metabolic process (GO:0006553)4.49126704
49lysine catabolic process (GO:0006554)4.49126704
50cellular ketone body metabolic process (GO:0046950)4.42444319
51negative regulation of sterol transport (GO:0032372)4.38801676
52negative regulation of cholesterol transport (GO:0032375)4.38801676
53coenzyme catabolic process (GO:0009109)4.37928526
54phospholipid efflux (GO:0033700)4.36178683
55bile acid and bile salt transport (GO:0015721)4.35146194
56indolalkylamine metabolic process (GO:0006586)4.33003899
57plasma lipoprotein particle clearance (GO:0034381)4.26669198
58cellular glucuronidation (GO:0052695)4.25919092
59glutamate metabolic process (GO:0006536)4.24118202
60imidazole-containing compound metabolic process (GO:0052803)4.22683607
61cellular amino acid catabolic process (GO:0009063)4.21986106
62cellular biogenic amine catabolic process (GO:0042402)4.19239550
63amine catabolic process (GO:0009310)4.19239550
64diaphragm development (GO:0060539)4.16519323
65glycine metabolic process (GO:0006544)4.13884794
66benzene-containing compound metabolic process (GO:0042537)4.08081912
67dicarboxylic acid biosynthetic process (GO:0043650)4.07841815
68cholesterol efflux (GO:0033344)4.07391431
69cellular modified amino acid catabolic process (GO:0042219)4.03958585
70endodermal cell differentiation (GO:0035987)4.01871867
71serine family amino acid metabolic process (GO:0009069)3.99646428
72ethanol oxidation (GO:0006069)3.97349731
73cell migration involved in heart development (GO:0060973)3.94841174
74fibrinolysis (GO:0042730)3.94224123
75arginine metabolic process (GO:0006525)3.93473375
76muscle filament sliding (GO:0030049)3.90818205
77actin-myosin filament sliding (GO:0033275)3.90818205
78actin-mediated cell contraction (GO:0070252)3.90259772
79negative regulation of vascular permeability (GO:0043116)3.88582635
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.88415063
81low-density lipoprotein particle remodeling (GO:0034374)3.84315449
82myoblast fusion (GO:0007520)3.83517052
83kidney mesenchyme development (GO:0072074)3.83470413
84ketone body metabolic process (GO:1902224)3.81853153
85positive regulation of lipid catabolic process (GO:0050996)3.80191157
86complement activation, classical pathway (GO:0006958)3.78719860
87plasma lipoprotein particle assembly (GO:0034377)3.77975082
88cytolysis (GO:0019835)3.77718979
89complement activation (GO:0006956)3.77675733
90serine family amino acid biosynthetic process (GO:0009070)3.76665141
91uronic acid metabolic process (GO:0006063)3.76643437
92glucuronate metabolic process (GO:0019585)3.76643437
93regulation of integrin-mediated signaling pathway (GO:2001044)3.76214151
94drug catabolic process (GO:0042737)3.75510656
95extracellular matrix assembly (GO:0085029)3.75309110
96negative regulation of lipase activity (GO:0060192)3.72755246
97aldehyde catabolic process (GO:0046185)3.72366280
98skeletal muscle organ development (GO:0060538)3.70764455
99regulation of bile acid biosynthetic process (GO:0070857)3.70645264
100cofactor catabolic process (GO:0051187)3.69695934
101protein activation cascade (GO:0072376)3.68808240
102regulation of cholesterol homeostasis (GO:2000188)3.68716125
103carboxylic acid catabolic process (GO:0046395)3.68622342
104organic acid catabolic process (GO:0016054)3.68622342
105acetyl-CoA metabolic process (GO:0006084)3.67222533
106phospholipid homeostasis (GO:0055091)3.66784785
107blood coagulation, intrinsic pathway (GO:0007597)3.66155092
108chondrocyte proliferation (GO:0035988)3.65762460
109short-chain fatty acid metabolic process (GO:0046459)3.65460387
110cholesterol homeostasis (GO:0042632)3.63024847
111negative regulation of nitric-oxide synthase activity (GO:0051001)3.61742233
112positive regulation of fatty acid beta-oxidation (GO:0032000)3.61653543
113regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.61238223
114bone trabecula formation (GO:0060346)3.60856869
115very-low-density lipoprotein particle assembly (GO:0034379)3.59687059
116negative regulation of calcium ion transport into cytosol (GO:0010523)3.58599522
117positive regulation of lipoprotein lipase activity (GO:0051006)3.58341799
118positive regulation of triglyceride lipase activity (GO:0061365)3.58341799
119sterol homeostasis (GO:0055092)3.57194544
120negative regulation of protein activation cascade (GO:2000258)3.54843238
121positive regulation of catecholamine secretion (GO:0033605)3.54188279
122opsonization (GO:0008228)3.53120086
123extracellular fibril organization (GO:0043206)3.50870896
124plasma lipoprotein particle organization (GO:0071827)3.46125354
125cellular response to vitamin (GO:0071295)3.40063869
126metanephric mesenchyme development (GO:0072075)3.38271504
127adhesion of symbiont to host cell (GO:0044650)3.30576052
128virion attachment to host cell (GO:0019062)3.30576052
129mesenchymal-epithelial cell signaling (GO:0060638)3.30381775
130type B pancreatic cell proliferation (GO:0044342)3.29011197
131negative regulation of neurotransmitter transport (GO:0051589)3.27832087
132regulation of skeletal muscle contraction (GO:0014819)3.27335550
133establishment of tissue polarity (GO:0007164)3.25980314
134establishment of planar polarity (GO:0001736)3.25980314
135regulation of the force of heart contraction (GO:0002026)3.21078398
136syncytium formation by plasma membrane fusion (GO:0000768)3.19201129
137epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18327737
138negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.15813987
139hypotonic response (GO:0006971)3.15303307
140regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.14959373
141negative regulation of protein localization to cell surface (GO:2000009)3.13798736
142cellular response to vitamin D (GO:0071305)3.12779028
143negative regulation of smooth muscle cell migration (GO:0014912)3.09361332
144negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07327202
145dermatan sulfate biosynthetic process (GO:0030208)3.06709629
146response to gravity (GO:0009629)3.04969357
147lymphangiogenesis (GO:0001946)3.04412435
148blood vessel maturation (GO:0001955)3.03692157
149substrate adhesion-dependent cell spreading (GO:0034446)3.00260763
150negative regulation of leukocyte chemotaxis (GO:0002689)2.96625503
151syncytium formation (GO:0006949)2.96194104
152dermatan sulfate metabolic process (GO:0030205)2.94395431
153positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93149889
154muscle cell fate commitment (GO:0042693)2.88994054
155negative regulation of homotypic cell-cell adhesion (GO:0034111)2.87594058
156pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.87332420
157UMP metabolic process (GO:0046049)2.87332420
158pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.87332420
159UMP biosynthetic process (GO:0006222)2.87332420
160skin morphogenesis (GO:0043589)2.84821950
161fibril organization (GO:0097435)2.83271726
162extracellular regulation of signal transduction (GO:1900115)2.82879715
163extracellular negative regulation of signal transduction (GO:1900116)2.82879715
164neuron projection extension involved in neuron projection guidance (GO:1902284)2.82242506
165axon extension involved in axon guidance (GO:0048846)2.82242506
166platelet-derived growth factor receptor signaling pathway (GO:0048008)2.80653219
167activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.79554878
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78935489
169lateral sprouting from an epithelium (GO:0060601)2.78920178
170negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.77557226
171positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77380248
172regulation of neurotransmitter uptake (GO:0051580)2.76680825
173endocardial cushion development (GO:0003197)2.75978317
174collagen metabolic process (GO:0032963)2.75972131
175cell adhesion mediated by integrin (GO:0033627)2.75750475
176regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.74824480
177cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71451898
178actin filament-based movement (GO:0030048)2.71141143
179negative regulation of axon extension involved in axon guidance (GO:0048843)2.70825201
180negative regulation of activin receptor signaling pathway (GO:0032926)2.69467232
181muscle organ development (GO:0007517)2.68933199
182muscle structure development (GO:0061061)2.68234257
183negative regulation of axon guidance (GO:1902668)2.65500473
184collagen catabolic process (GO:0030574)2.64262161
185cell migration involved in sprouting angiogenesis (GO:0002042)2.63869432
186adhesion of symbiont to host (GO:0044406)2.62289579
187negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.61958618
188negative regulation of BMP signaling pathway (GO:0030514)2.60862767
189smooth muscle tissue development (GO:0048745)2.60383639
190negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.58623567
191planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56826488
192relaxation of smooth muscle (GO:0044557)2.52792694
193regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52477482
194substrate-dependent cell migration (GO:0006929)2.51949483
195cardiac myofibril assembly (GO:0055003)2.51752406
196negative regulation of potassium ion transmembrane transport (GO:1901380)2.51482363
197actin filament depolymerization (GO:0030042)2.49984641
198negative regulation of potassium ion transport (GO:0043267)2.48591702
199positive regulation of axon extension (GO:0045773)2.48584686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.94850069
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.71248331
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.54314130
4EZH2_22144423_ChIP-Seq_EOC_Human6.52160319
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.17170295
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.01692740
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72335579
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.57453390
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98991546
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.52599824
11* CJUN_26792858_Chip-Seq_BT549_Human2.72460849
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.56049806
13* BRD4_25478319_ChIP-Seq_HGPS_Human2.47431679
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.43858941
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.36488851
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13516972
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.13011854
18* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11950496
19ZNF274_21170338_ChIP-Seq_K562_Hela2.07668715
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01563921
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.01441878
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00837818
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2781173
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97981830
25TP53_16413492_ChIP-PET_HCT116_Human1.96069327
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84483095
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84293542
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83697021
29* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82232337
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79852999
31MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.78813985
32* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.71939120
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70765105
34* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70365828
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70222616
36* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67630351
37TP53_18474530_ChIP-ChIP_U2OS_Human1.64989718
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.64704054
39* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64117703
40TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.62247967
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58513646
42HTT_18923047_ChIP-ChIP_STHdh_Human1.57755373
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54910430
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51548680
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48995023
46CLOCK_20551151_ChIP-Seq_293T_Human1.48685598
47* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43864007
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41650190
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41650190
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41510847
51SMAD4_21799915_ChIP-Seq_A2780_Human1.34823217
52* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33420355
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.31801241
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31348984
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.31006438
56* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28609564
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.28527825
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26193823
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24396710
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24126424
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23988293
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.22923277
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20942987
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.20880409
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20470802
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19813845
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17845757
68GATA1_22025678_ChIP-Seq_K562_Human1.16971550
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16690907
70* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16008791
71JUN_21703547_ChIP-Seq_K562_Human1.15703978
72TP53_23651856_ChIP-Seq_MEFs_Mouse1.14742892
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14627864
74* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14603382
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14598368
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11795936
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11701014
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11088299
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10999849
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10414555
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10292216
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.09030925
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07346124
84* P300_19829295_ChIP-Seq_ESCs_Human1.05270174
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04469373
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03400579
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02799711
88AR_25329375_ChIP-Seq_VCAP_Human1.02745495
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.01896492
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01621815
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01068893
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00332748
93FUS_26573619_Chip-Seq_HEK293_Human0.99809231
94KDM2B_26808549_Chip-Seq_REH_Human0.99607164
95* STAT3_23295773_ChIP-Seq_U87_Human0.98807470
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.98478748
97AHR_22903824_ChIP-Seq_MCF-7_Human0.98286027
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98275777
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98248919
100TAF15_26573619_Chip-Seq_HEK293_Human0.98132078
101SA1_22415368_ChIP-Seq_MEFs_Mouse0.96028515
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95984007
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95984007
104SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95917705
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95609786
106PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.95584602
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94436691
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94330268
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93600423
110CRX_20693478_ChIP-Seq_RETINA_Mouse0.93198653
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92999934
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.92984772
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.92984772
114P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92904500
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92736536
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92566450
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92188571
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.91446100
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89826130
120AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84141749
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79143066
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76759634
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76005014
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75711841
125BCAT_22108803_ChIP-Seq_LS180_Human0.73520050
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72954535
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71605439
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70169546
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.69749552
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69436569
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.69258004
132ZNF263_19887448_ChIP-Seq_K562_Human0.68765454
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67857535
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66620711
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.66342329
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65342909
137GATA4_25053715_ChIP-Seq_YYC3_Human0.62898587
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.60328028
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.60205088
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.59873020
141RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58850467
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56188793
143KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55966091
144EGR1_19032775_ChIP-ChIP_M12_Human0.55524809
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.55062872
146GBX2_23144817_ChIP-Seq_PC3_Human0.54837826
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.54045558
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.51945240
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.51908296
150MYC_19915707_ChIP-ChIP_AK7_Human0.51539096
151CBP_21632823_ChIP-Seq_H3396_Human0.50124504
152MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.49513470
153CEBPB_22108803_ChIP-Seq_LS180_Human0.49018130
154FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48259600
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.47906317
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.47013635
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.46967048
158ZNF217_24962896_ChIP-Seq_MCF-7_Human0.46601153
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.46358635
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.45756344
161LXR_22292898_ChIP-Seq_THP-1_Human0.45564834
162STAT1_17558387_ChIP-Seq_HELA_Human0.45422947
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44792058
164* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44428375
165AR_20517297_ChIP-Seq_VCAP_Human0.44368677
166TRIM28_21343339_ChIP-Seq_HEK293_Human0.44065099
167FOXO3_23340844_ChIP-Seq_DLD1_Human0.43356311
168ESET_19884257_ChIP-Seq_ESCs_Mouse0.42859129
169RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.42602092
170PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42369686
171NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.42279304
172STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41794158
173PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41434307
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.41371223
175ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41086644
176* SMAD4_21741376_ChIP-Seq_HESCs_Human0.40100723
177* SMAD4_21741376_ChIP-Seq_EPCs_Human0.38690838
178FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.38534804
179SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38338599
180DNAJC2_21179169_ChIP-ChIP_NT2_Human0.38011619
181PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.37654610
182SOX2_20726797_ChIP-Seq_SW620_Human0.37146658
183FOXM1_26456572_ChIP-Seq_MCF-7_Human0.37040619
184FOXH1_21741376_ChIP-Seq_EPCs_Human0.36958396
185CDX2_22108803_ChIP-Seq_LS180_Human0.36773162
186OCT4_21477851_ChIP-Seq_ESCs_Mouse0.36558483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30728692
2MP0005360_urolithiasis7.63043125
3MP0008438_abnormal_cutaneous_collagen6.53617969
4MP0005085_abnormal_gallbladder_physiolo6.46779449
5MP0005365_abnormal_bile_salt6.17761739
6MP0008875_abnormal_xenobiotic_pharmacok5.15027814
7MP0003806_abnormal_nucleotide_metabolis4.06508118
8MP0003252_abnormal_bile_duct3.93313890
9MP0003279_aneurysm3.71307683
10MP0005503_abnormal_tendon_morphology3.71061898
11MP0010329_abnormal_lipoprotein_level3.69979907
12MP0003646_muscle_fatigue3.62575646
13MP0001958_emphysema3.13971560
14MP0009840_abnormal_foam_cell3.05104716
15MP0002234_abnormal_pharynx_morphology2.98073791
16MP0005083_abnormal_biliary_tract2.96355000
17MP0003950_abnormal_plasma_membrane2.93535674
18MP0005275_abnormal_skin_tensile2.90085615
19MP0004084_abnormal_cardiac_muscle2.90047864
20MP0005332_abnormal_amino_acid2.68784565
21MP0003195_calcinosis2.67543739
22MP0004272_abnormal_basement_membrane2.67469562
23MP0001666_abnormal_nutrient_absorption2.51349978
24MP0004233_abnormal_muscle_weight2.49458402
25MP0006054_spinal_hemorrhage2.46284829
26MP0003191_abnormal_cellular_cholesterol2.34121807
27MP0001542_abnormal_bone_strength2.30773004
28MP0005623_abnormal_meninges_morphology2.27568949
29MP0000751_myopathy2.23442750
30MP0000749_muscle_degeneration2.17073423
31MP0002118_abnormal_lipid_homeostasis2.13522630
32MP0004036_abnormal_muscle_relaxation2.10944408
33MP0004858_abnormal_nervous_system2.10757136
34MP0000609_abnormal_liver_physiology2.09512957
35MP0003283_abnormal_digestive_organ2.09094220
36MP0000767_abnormal_smooth_muscle2.02845063
37MP0004019_abnormal_vitamin_homeostasis2.02682025
38MP0005257_abnormal_intraocular_pressure2.02114129
39MP0003868_abnormal_feces_composition1.89686011
40MP0000013_abnormal_adipose_tissue1.88997460
41MP0000733_abnormal_muscle_development1.84793548
42MP0003566_abnormal_cell_adhesion1.84604902
43MP0004043_abnormal_pH_regulation1.75271906
44MP0005319_abnormal_enzyme/_coenzyme1.73801261
45MP0010030_abnormal_orbit_morphology1.72005860
46MP0001879_abnormal_lymphatic_vessel1.70537766
47MP0002138_abnormal_hepatobiliary_system1.70155748
48MP0005508_abnormal_skeleton_morphology1.68369544
49MP0009697_abnormal_copulation1.63507630
50MP0001764_abnormal_homeostasis1.62700860
51MP0002108_abnormal_muscle_morphology1.61770055
52MP0009250_abnormal_appendicular_skeleto1.58722798
53MP0005584_abnormal_enzyme/coenzyme_acti1.55904860
54MP0008775_abnormal_heart_ventricle1.48169643
55MP0010386_abnormal_urinary_bladder1.45914943
56MP0000759_abnormal_skeletal_muscle1.43960527
57MP0000750_abnormal_muscle_regeneration1.43170127
58MP0004145_abnormal_muscle_electrophysio1.41155924
59MP0003705_abnormal_hypodermis_morpholog1.41001995
60MP0003091_abnormal_cell_migration1.40450540
61MP0000534_abnormal_ureter_morphology1.38080654
62MP0005620_abnormal_muscle_contractility1.34195608
63MP0003011_delayed_dark_adaptation1.30545348
64MP0005451_abnormal_body_composition1.25648281
65MP0003045_fibrosis1.25358803
66MP0005171_absent_coat_pigmentation1.23831291
67MP0004134_abnormal_chest_morphology1.16959680
68MP0002896_abnormal_bone_mineralization1.16209905
69MP0000163_abnormal_cartilage_morphology1.16083186
70MP0001299_abnormal_eye_distance/1.14889089
71MP0005023_abnormal_wound_healing1.13998474
72MP0005647_abnormal_sex_gland1.13654710
73MP0003942_abnormal_urinary_system1.11539338
74MP0009643_abnormal_urine_homeostasis1.10297625
75MP0005369_muscle_phenotype1.10177813
76MP0000604_amyloidosis1.08788668
77MP0000598_abnormal_liver_morphology1.08664004
78MP0003186_abnormal_redox_activity1.06974417
79MP0003656_abnormal_erythrocyte_physiolo1.06368443
80MP0002106_abnormal_muscle_physiology1.05811554
81MP0005645_abnormal_hypothalamus_physiol1.05703210
82MP0010368_abnormal_lymphatic_system1.03356942
83MP0002254_reproductive_system_inflammat1.02167231
84MP0002876_abnormal_thyroid_physiology1.00808583
85MP0000566_synostosis1.00259896
86MP0006138_congestive_heart_failure0.99457120
87MP0002127_abnormal_cardiovascular_syste0.98288085
88MP0005197_abnormal_uvea_morphology0.97291709
89MP0009764_decreased_sensitivity_to0.96887595
90MP0002233_abnormal_nose_morphology0.96557163
91MP0009763_increased_sensitivity_to0.96177250
92MP0002115_abnormal_skeleton_extremities0.94308218
93MP0000428_abnormal_craniofacial_morphol0.93600182
94MP0005670_abnormal_white_adipose0.92963124
95MP0005390_skeleton_phenotype0.91719460
96MP0002113_abnormal_skeleton_development0.91692908
97MP0006082_CNS_inflammation0.90294439
98MP0001661_extended_life_span0.89270199
99MP0004087_abnormal_muscle_fiber0.88599265
100MP0002128_abnormal_blood_circulation0.86987380
101MP0003937_abnormal_limbs/digits/tail_de0.86732603
102MP0000467_abnormal_esophagus_morphology0.86326915
103MP0002109_abnormal_limb_morphology0.85068135
104MP0002972_abnormal_cardiac_muscle0.84834541
105MP0004130_abnormal_muscle_cell0.84725510
106MP0000049_abnormal_middle_ear0.84074834
107MP0002116_abnormal_craniofacial_bone0.83488351
108MP0002971_abnormal_brown_adipose0.83303817
109MP0005167_abnormal_blood-brain_barrier0.82482788
110MP0005636_abnormal_mineral_homeostasis0.81625469
111MP0009642_abnormal_blood_homeostasis0.81545153
112MP0002078_abnormal_glucose_homeostasis0.80872064
113MP0004484_altered_response_of0.80577076
114MP0000538_abnormal_urinary_bladder0.80483775
115MP0003755_abnormal_palate_morphology0.79279635
116MP0005535_abnormal_body_temperature0.78680946
117MP0000432_abnormal_head_morphology0.78418089
118MP0009053_abnormal_anal_canal0.78319954
119MP0005084_abnormal_gallbladder_morpholo0.77815767
120MP0000639_abnormal_adrenal_gland0.77680631
121MP0002932_abnormal_joint_morphology0.77508719
122MP0005376_homeostasis/metabolism_phenot0.76838474
123MP0005334_abnormal_fat_pad0.76733630
124MP0003329_amyloid_beta_deposits0.74199743
125MP0006036_abnormal_mitochondrial_physio0.73289614
126MP0005408_hypopigmentation0.73241203
127MP0002332_abnormal_exercise_endurance0.72983045
128MP0008469_abnormal_protein_level0.72746583
129MP0003690_abnormal_glial_cell0.71618972
130MP0003385_abnormal_body_wall0.70425777
131MP0001664_abnormal_digestion0.69934735
132MP0009765_abnormal_xenobiotic_induced0.68285539
133MP0005220_abnormal_exocrine_pancreas0.67791907
134MP0002282_abnormal_trachea_morphology0.65147749
135MP0005448_abnormal_energy_balance0.64803832
136MP0002114_abnormal_axial_skeleton0.63846540
137MP0001544_abnormal_cardiovascular_syste0.63638488
138MP0005385_cardiovascular_system_phenoty0.63638488
139MP0004133_heterotaxia0.63018132
140MP0002837_dystrophic_cardiac_calcinosis0.62942181
141MP0000762_abnormal_tongue_morphology0.62548673
142MP0002822_catalepsy0.62379111
143MP0005266_abnormal_metabolism0.61813448
144MP0000747_muscle_weakness0.61519318
145MP0002269_muscular_atrophy0.60120358
146MP0000003_abnormal_adipose_tissue0.58527857
147MP0005248_abnormal_Harderian_gland0.58364405
148MP0003941_abnormal_skin_development0.57705374
149MP0001756_abnormal_urination0.56232018
150MP0006035_abnormal_mitochondrial_morpho0.55767215
151MP0008874_decreased_physiological_sensi0.54557107
152MP0005666_abnormal_adipose_tissue0.51122683
153MP0003638_abnormal_response/metabolism_0.48654421
154MP0009384_cardiac_valve_regurgitation0.46373383
155MP0005187_abnormal_penis_morphology0.44616137
156MP0000579_abnormal_nail_morphology0.44472624
157MP0005395_other_phenotype0.43712986
158MP0003953_abnormal_hormone_level0.42410386
159MP0008872_abnormal_physiological_respon0.41988108
160MP0009115_abnormal_fat_cell0.41149045
161MP0002168_other_aberrant_phenotype0.39750038
162MP0002928_abnormal_bile_duct0.38866941
163MP0003075_altered_response_to0.37807947
164MP0004883_abnormal_blood_vessel0.36801400
165MP0000230_abnormal_systemic_arterial0.36570216
166MP0009672_abnormal_birth_weight0.36156453
167MP0000427_abnormal_hair_cycle0.36144614
168MP0008873_increased_physiological_sensi0.35696409
169MP0002090_abnormal_vision0.35078172
170MP0002970_abnormal_white_adipose0.34688433
171MP0003724_increased_susceptibility_to0.34171263
172MP0005166_decreased_susceptibility_to0.32925855
173MP0004782_abnormal_surfactant_physiolog0.32860882
174MP0002136_abnormal_kidney_physiology0.32486394
175MP0005595_abnormal_vascular_smooth0.31821478
176MP0004381_abnormal_hair_follicle0.31589215
177MP0005464_abnormal_platelet_physiology0.30619690
178MP0001243_abnormal_dermal_layer0.29715760
179MP0003959_abnormal_lean_body0.28229736
180MP0002060_abnormal_skin_morphology0.28030374
181MP0001881_abnormal_mammary_gland0.27907504
182MP0005164_abnormal_response_to0.27565529
183MP0002796_impaired_skin_barrier0.27142399
184MP0002295_abnormal_pulmonary_circulatio0.26682414
185MP0000249_abnormal_blood_vessel0.26285611
186MP0009780_abnormal_chondrocyte_physiolo0.23334463

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.66232685
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.41221894
3Intrahepatic cholestasis (HP:0001406)7.38304509
4Premature rupture of membranes (HP:0001788)6.87234997
5Prolonged partial thromboplastin time (HP:0003645)6.65596885
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58698249
7Hypobetalipoproteinemia (HP:0003563)6.37240724
8Xanthomatosis (HP:0000991)6.29850375
9Type 1 muscle fiber predominance (HP:0003803)6.26386153
10Protrusio acetabuli (HP:0003179)6.13292506
11Hyperlipoproteinemia (HP:0010980)5.69519506
12Complement deficiency (HP:0004431)5.67166357
13Hypolipoproteinemia (HP:0010981)4.79893379
14Aortic aneurysm (HP:0004942)4.79007002
15Epidermoid cyst (HP:0200040)4.73614867
16Joint hemorrhage (HP:0005261)4.67209540
17Nemaline bodies (HP:0003798)4.64036316
18Aortic dissection (HP:0002647)4.58656544
19Hyperammonemia (HP:0001987)4.57017240
20Ankle contracture (HP:0006466)4.54955923
21Abnormality of the common coagulation pathway (HP:0010990)4.54610041
22Hyperglycinemia (HP:0002154)4.43338608
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.40935436
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40626647
25Muscle fiber inclusion bodies (HP:0100299)4.34455095
26Abnormality of methionine metabolism (HP:0010901)4.29989910
27Ketosis (HP:0001946)4.25807301
28Hypoalphalipoproteinemia (HP:0003233)4.24099522
29Abnormality of sulfur amino acid metabolism (HP:0004339)4.23134532
30Neonatal short-limb short stature (HP:0008921)4.17148359
31Follicular hyperkeratosis (HP:0007502)4.15667845
32Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12343768
33Fat malabsorption (HP:0002630)4.09147651
34Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08675663
35Abnormality of complement system (HP:0005339)4.08542895
36Soft skin (HP:0000977)4.03190477
37Slender build (HP:0001533)3.96386413
38Abnormality of glycine metabolism (HP:0010895)3.88867964
39Abnormality of serine family amino acid metabolism (HP:0010894)3.88867964
40Spinal rigidity (HP:0003306)3.88633856
41Hyperglycinuria (HP:0003108)3.85865299
42Conjugated hyperbilirubinemia (HP:0002908)3.77453512
43Abnormality of the intrinsic pathway (HP:0010989)3.76774583
44Hypoglycemic coma (HP:0001325)3.73831731
45Hypercholesterolemia (HP:0003124)3.68439056
46Abnormality of pyrimidine metabolism (HP:0004353)3.56849547
47Vascular tortuosity (HP:0004948)3.52329831
48Bladder diverticulum (HP:0000015)3.41627993
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36533903
50Round ear (HP:0100830)3.32298001
51Delayed CNS myelination (HP:0002188)3.27773741
52Abnormality of dentin (HP:0010299)3.26929448
53Hyperbilirubinemia (HP:0002904)3.26700749
54Abnormality of fatty-acid metabolism (HP:0004359)3.24755817
55Popliteal pterygium (HP:0009756)3.21426367
56Spontaneous abortion (HP:0005268)3.17313890
57Steatorrhea (HP:0002570)3.08754316
58Abnormality of serum amino acid levels (HP:0003112)3.04886743
59Genu recurvatum (HP:0002816)3.03373943
60Ketoacidosis (HP:0001993)3.03301601
61Blue sclerae (HP:0000592)3.01508331
62Skin nodule (HP:0200036)2.93107538
63Myocardial infarction (HP:0001658)2.92146516
64Hypochromic microcytic anemia (HP:0004840)2.91371517
65Atrophic scars (HP:0001075)2.90992695
66Abnormality of nucleobase metabolism (HP:0010932)2.88942644
67Hepatocellular carcinoma (HP:0001402)2.87308677
68Peritonitis (HP:0002586)2.85380749
69Sparse lateral eyebrow (HP:0005338)2.82336201
70Mildly elevated creatine phosphokinase (HP:0008180)2.81761729
71Shallow orbits (HP:0000586)2.79488815
72Increased variability in muscle fiber diameter (HP:0003557)2.78775878
73Ulnar deviation of the wrist (HP:0003049)2.71175368
74Arterial tortuosity (HP:0005116)2.70963775
75Broad metatarsal (HP:0001783)2.70468744
76Distal arthrogryposis (HP:0005684)2.70250259
77Cervical subluxation (HP:0003308)2.68898989
78Wrist flexion contracture (HP:0001239)2.68646218
79Fragile skin (HP:0001030)2.68636148
80Metabolic acidosis (HP:0001942)2.67357908
81Systemic lupus erythematosus (HP:0002725)2.66980914
82Wormian bones (HP:0002645)2.65097014
83Abnormality of skeletal muscle fiber size (HP:0012084)2.64314716
84Short 5th finger (HP:0009237)2.58897371
85Mesomelia (HP:0003027)2.56746489
86Wide anterior fontanel (HP:0000260)2.55187690
87Abnormality of purine metabolism (HP:0004352)2.54989192
88Mitral stenosis (HP:0001718)2.53511219
89Lethargy (HP:0001254)2.51198891
90Calcaneovalgus deformity (HP:0001848)2.50216518
91Deformed tarsal bones (HP:0008119)2.49613878
92Abnormal gallbladder morphology (HP:0012437)2.49446249
93Reduced subcutaneous adipose tissue (HP:0003758)2.46845432
94Mild short stature (HP:0003502)2.45435467
95Vascular calcification (HP:0004934)2.43787323
96Aortic valve stenosis (HP:0001650)2.43592878
97Cholelithiasis (HP:0001081)2.43318626
98Acanthocytosis (HP:0001927)2.42968431
99Dicarboxylic aciduria (HP:0003215)2.42709310
100Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42709310
101Neonatal onset (HP:0003623)2.41936190
102Spondylolisthesis (HP:0003302)2.40499150
103Autoimmune thrombocytopenia (HP:0001973)2.40255018
104Spastic diplegia (HP:0001264)2.39684661
105Abnormal delivery (HP:0001787)2.38806154
106Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.36392845
107Dilatation of the ascending aorta (HP:0005111)2.35869877
108Bowel diverticulosis (HP:0005222)2.35649653
109Abnormal gallbladder physiology (HP:0012438)2.35523064
110Cholecystitis (HP:0001082)2.35523064
111Hypoglycemic seizures (HP:0002173)2.35243613
112Cerebral edema (HP:0002181)2.32861087
113Gout (HP:0001997)2.31907125
114Glomerulonephritis (HP:0000099)2.31422500
115Depressed nasal tip (HP:0000437)2.30757036
116Absent phalangeal crease (HP:0006109)2.28730366
117Amyloidosis (HP:0011034)2.28194621
118Irritability (HP:0000737)2.28153461
119Lip pit (HP:0100267)2.26755547
120Recurrent gram-negative bacterial infections (HP:0005420)2.26553294
121Redundant skin (HP:0001582)2.26261461
122Infantile muscular hypotonia (HP:0008947)2.24390141
123Cardiovascular calcification (HP:0011915)2.23704604
124Congenital hip dislocation (HP:0001374)2.22081542
125Delayed gross motor development (HP:0002194)2.21076744
126Hyperextensible skin (HP:0000974)2.20451034
127Natal tooth (HP:0000695)2.19693109
128Sensorimotor neuropathy (HP:0007141)2.16943850
129Brushfield spots (HP:0001088)2.15843575
130Decreased subcutaneous fat (HP:0001002)2.15822698
131Aortic regurgitation (HP:0001659)2.14964690
132Hypoventilation (HP:0002791)2.14317364
133Aplasia of the musculature (HP:0100854)2.14006194
134Abnormality of the calf musculature (HP:0001430)2.12493026
135Esophageal varix (HP:0002040)2.12379111
136Enlarged kidneys (HP:0000105)2.11287389
137Malnutrition (HP:0004395)2.10751183
138Breech presentation (HP:0001623)2.09224885
139Mitral valve prolapse (HP:0001634)2.09067737
140Gingival bleeding (HP:0000225)2.08318580
141Hip contracture (HP:0003273)2.08299971
142Pancreatitis (HP:0001733)2.06369932
143Status epilepticus (HP:0002133)2.05785671
144Menorrhagia (HP:0000132)2.03964540
145Hemorrhage of the eye (HP:0011885)2.03504178
146Increased corneal curvature (HP:0100692)2.02878809
147Keratoconus (HP:0000563)2.02878809
148Late onset (HP:0003584)2.02167380
149Limb-girdle muscle weakness (HP:0003325)2.01699909
150Abnormality of the gallbladder (HP:0005264)2.01025814
151Vomiting (HP:0002013)2.00119853
152Thrombophlebitis (HP:0004418)1.98952042
153Opisthotonus (HP:0002179)1.96877438
154Exercise-induced muscle cramps (HP:0003710)1.95846985
155Mitral regurgitation (HP:0001653)1.92877851
156Joint laxity (HP:0001388)1.90310875
157Increased connective tissue (HP:0009025)1.89919824
158Elbow flexion contracture (HP:0002987)1.89296652
159Hyperinsulinemic hypoglycemia (HP:0000825)1.88441222
160Rickets (HP:0002748)1.85211361
161Pterygium (HP:0001059)1.84879501
162Poikilocytosis (HP:0004447)1.83667429
163Abnormal cartilage morphology (HP:0002763)1.81630183
164Generalized aminoaciduria (HP:0002909)1.81615571
165Abnormal finger flexion creases (HP:0006143)1.81490187
166Delayed closure of the anterior fontanelle (HP:0001476)1.81112073
167Hydroxyprolinuria (HP:0003080)1.80496668
168Abnormality of proline metabolism (HP:0010907)1.80496668
169Joint stiffness (HP:0001387)1.80454249
170Hyperventilation (HP:0002883)1.80200712
171Biconcave vertebral bodies (HP:0004586)1.79345839
172Hyperglycemia (HP:0003074)1.79041277
173Limited hip movement (HP:0008800)1.78726281
174Hypophosphatemic rickets (HP:0004912)1.77834324
175Overgrowth (HP:0001548)1.77150999
176Renal cortical cysts (HP:0000803)1.76871136
177Generalized amyotrophy (HP:0003700)1.76759224
178Morphological abnormality of the middle ear (HP:0008609)1.75730207
179Broad long bones (HP:0005622)1.75307550
180Abnormality of the neuromuscular junction (HP:0003398)1.75305279
181Fatigable weakness (HP:0003473)1.75305279
182Gowers sign (HP:0003391)1.73776110
183Abnormality of vitamin metabolism (HP:0100508)1.72770902
184Turricephaly (HP:0000262)1.71407254
185Alkalosis (HP:0001948)1.71389508
186Elevated hepatic transaminases (HP:0002910)1.71017734
187Acute hepatic failure (HP:0006554)1.70745693
188Vertebral compression fractures (HP:0002953)1.69957520
189Hypertriglyceridemia (HP:0002155)1.69526496
190Narrow palate (HP:0000189)1.68704146
191Neck muscle weakness (HP:0000467)1.67613205
192Ectopia lentis (HP:0001083)1.67169367
193Type 2 muscle fiber atrophy (HP:0003554)1.66649607
194Exercise-induced myalgia (HP:0003738)1.64905783
195Muscle hypertrophy of the lower extremities (HP:0008968)1.64668224
196Lipoatrophy (HP:0100578)1.63390222
197Urinary glycosaminoglycan excretion (HP:0003541)1.62105491
198Mucopolysacchariduria (HP:0008155)1.62105491
199Tarsal synostosis (HP:0008368)1.61514902
200Broad ribs (HP:0000885)1.61274096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.31209382
2SIK14.89372474
3STK244.54411103
4WNK44.21340151
5FGFR44.05726876
6ERN13.94294716
7MYLK3.74118498
8CCNB13.45755620
9STK393.44272173
10MAP2K42.86341695
11LIMK12.86010737
12INSRR2.84077709
13ERBB42.83360513
14MUSK2.79899002
15TTN2.58410841
16ILK2.47026807
17OBSCN2.41144171
18TAOK32.34061485
19DDR22.24548761
20DAPK22.20463506
21MST1R2.16846461
22LATS12.07988344
23PKN21.84459464
24FGFR21.82832787
25MAPKAPK31.80869156
26TRIB31.74199962
27MAPK111.72355508
28TRPM71.69056807
29PIK3CG1.67360981
30PAK21.64660590
31MOS1.61644372
32JAK31.53828343
33WNK11.51872788
34FRK1.50909492
35EPHA31.46438204
36FLT31.45473797
37CAMKK21.44393013
38EPHA41.40643555
39PTK61.40512906
40EPHB21.39371061
41PTK2B1.36705226
42TESK11.34891523
43ADRBK11.31948534
44CAMK1D1.30971148
45TYK21.26713265
46ABL21.24145472
47ADRBK21.22733385
48PAK61.22468033
49CAMK11.22015382
50MAP3K71.20668372
51ZAK1.19771026
52MAP3K21.19264499
53NEK91.16363632
54JAK21.15225481
55PHKG11.10609782
56PHKG21.10609782
57GRK11.10145747
58ROCK11.07008031
59PRKAA21.05852732
60MARK11.00861149
61RIPK10.99421352
62PRKD20.99032548
63PINK10.98286788
64PRKCZ0.97923770
65JAK10.96418231
66KIT0.95785307
67CAMK1G0.93327437
68MAPK40.90896002
69ERBB20.89918743
70GRK70.88842814
71LATS20.88518274
72EEF2K0.88437858
73SGK30.86031702
74RPS6KA60.84361028
75MAPK120.83867252
76MET0.81669298
77MAP4K20.81611217
78CDK60.81231137
79TNIK0.81005392
80CHEK20.80788621
81PLK20.80341546
82RPS6KC10.77791438
83RPS6KL10.77791438
84GRK60.77079099
85KDR0.76608448
86CAMK2G0.76384229
87STK38L0.75562067
88PRKACG0.74814933
89MAPK70.74025995
90MAP3K40.72777380
91PRKG20.72338654
92PIK3CA0.71768510
93PRKCG0.71476540
94CAMKK10.69203557
95PDGFRB0.67121305
96PTK20.67071575
97SGK20.66611746
98PDGFRA0.66165710
99PRKAA10.65406685
100GSK3A0.65107064
101PRKCE0.64786771
102RET0.62928108
103EPHB10.62503174
104MAP2K60.61298181
105SIK20.60432635
106PDPK10.59340909
107SGK2230.58291201
108SGK4940.58291201
109MAP2K10.57517071
110PNCK0.57345002
111ERBB30.56225138
112FGFR30.55831356
113MAP3K110.55690435
114DAPK30.55253391
115FER0.55171829
116ROCK20.54491948
117CASK0.54447469
118BMPR1B0.54149163
119MAPK130.53743410
120DYRK1B0.53123041
121MAP2K30.51548457
122MAP3K100.50749141
123MAPK150.50592712
124RPS6KA20.50428929
125TBK10.50351329
126PAK30.49757654
127GRK50.49450765
128IGF1R0.49250078
129PRKCQ0.49012030
130CDC42BPA0.48327647
131TIE10.46894297
132CAMK2A0.46778169
133FGFR10.45376926
134AKT30.45063627
135CAMK40.44812560
136TAOK20.43485658
137MELK0.42370605
138MAP3K140.41394519
139CSNK1G10.41299445
140MAP3K30.40962103
141NEK20.40783200
142MAP2K70.39680062
143CAMK2D0.39523810
144MAP3K50.38923043
145PAK10.38458287
146CSK0.38444114
147DMPK0.37880153
148TGFBR10.37629679
149NTRK20.37179045
150DAPK10.36956691
151CSNK1G20.36954288
152IRAK20.36775627
153PKN10.36603174
154PDK10.36355712
155NTRK10.35739791
156CDK90.34306049
157PRKCH0.33905548
158MTOR0.33406633
159PRKG10.32666741
160MAP3K10.32273321
161STK380.32201839
162PRKCA0.32089470
163LMTK20.31273290
164TGFBR20.29417525
165EGFR0.29266481
166BMX0.28937077
167ABL10.28682414
168MINK10.28537074
169DYRK30.27500050
170NUAK10.27348973
171CDK80.26175482
172STK160.24792861

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.62148283
2ECM-receptor interaction_Homo sapiens_hsa045124.20792895
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.74737236
4Nitrogen metabolism_Homo sapiens_hsa009103.74605308
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45435896
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34162787
7Dilated cardiomyopathy_Homo sapiens_hsa054143.30566906
8Arginine biosynthesis_Homo sapiens_hsa002203.12999685
9Focal adhesion_Homo sapiens_hsa045102.88086970
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.87722622
11Complement and coagulation cascades_Homo sapiens_hsa046102.80417142
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68648171
13Tryptophan metabolism_Homo sapiens_hsa003802.67400989
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60692501
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.52242595
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47428418
17Fatty acid degradation_Homo sapiens_hsa000712.45169789
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37508126
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19838772
20Butanoate metabolism_Homo sapiens_hsa006502.18393403
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09737948
22Peroxisome_Homo sapiens_hsa041462.06522430
23Propanoate metabolism_Homo sapiens_hsa006401.93927561
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.93793688
25Chemical carcinogenesis_Homo sapiens_hsa052041.93488900
26PPAR signaling pathway_Homo sapiens_hsa033201.92625921
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88996638
28Protein digestion and absorption_Homo sapiens_hsa049741.85540682
29Histidine metabolism_Homo sapiens_hsa003401.84820786
30Fatty acid metabolism_Homo sapiens_hsa012121.80865508
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77763284
32Phototransduction_Homo sapiens_hsa047441.76901016
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.72627665
34Staphylococcus aureus infection_Homo sapiens_hsa051501.71612778
35Caffeine metabolism_Homo sapiens_hsa002321.71609600
36Retinol metabolism_Homo sapiens_hsa008301.70316201
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.70135198
38TGF-beta signaling pathway_Homo sapiens_hsa043501.68998404
39beta-Alanine metabolism_Homo sapiens_hsa004101.68862683
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62761614
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61179829
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59116664
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58644021
44Phenylalanine metabolism_Homo sapiens_hsa003601.57946714
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.57464512
46Bile secretion_Homo sapiens_hsa049761.56783447
47Proteoglycans in cancer_Homo sapiens_hsa052051.54001681
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48730999
49Selenocompound metabolism_Homo sapiens_hsa004501.47201229
50Hedgehog signaling pathway_Homo sapiens_hsa043401.46912244
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46610679
52PI3K-Akt signaling pathway_Homo sapiens_hsa041511.45245312
53Tyrosine metabolism_Homo sapiens_hsa003501.44926110
54Hippo signaling pathway_Homo sapiens_hsa043901.44655053
55Calcium signaling pathway_Homo sapiens_hsa040201.40571766
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40393489
57Platelet activation_Homo sapiens_hsa046111.37281879
58Pyruvate metabolism_Homo sapiens_hsa006201.35599750
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34528801
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31427862
61Oxytocin signaling pathway_Homo sapiens_hsa049211.30611555
62Sulfur metabolism_Homo sapiens_hsa009201.27533255
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26838587
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.26090955
65Starch and sucrose metabolism_Homo sapiens_hsa005001.25781995
66Melanoma_Homo sapiens_hsa052181.25045103
67Fatty acid elongation_Homo sapiens_hsa000621.24905125
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24344343
69Circadian entrainment_Homo sapiens_hsa047131.22602561
70Gap junction_Homo sapiens_hsa045401.19911258
71ABC transporters_Homo sapiens_hsa020101.17513672
72Salivary secretion_Homo sapiens_hsa049701.16033657
73Cardiac muscle contraction_Homo sapiens_hsa042601.15585239
74Biosynthesis of amino acids_Homo sapiens_hsa012301.14108103
75Fat digestion and absorption_Homo sapiens_hsa049751.11427296
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11088572
77Steroid biosynthesis_Homo sapiens_hsa001001.09981374
78Folate biosynthesis_Homo sapiens_hsa007901.08661840
79Carbon metabolism_Homo sapiens_hsa012001.07676636
80Olfactory transduction_Homo sapiens_hsa047401.07392888
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04416177
82Basal cell carcinoma_Homo sapiens_hsa052171.03235449
83Adherens junction_Homo sapiens_hsa045200.99542509
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97194469
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93846600
86Long-term depression_Homo sapiens_hsa047300.93054103
87Vitamin B6 metabolism_Homo sapiens_hsa007500.92425485
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.90985709
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90697568
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.88627605
91Arginine and proline metabolism_Homo sapiens_hsa003300.88264575
92p53 signaling pathway_Homo sapiens_hsa041150.88240423
93Melanogenesis_Homo sapiens_hsa049160.87985143
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87671031
95Sulfur relay system_Homo sapiens_hsa041220.86721009
96Malaria_Homo sapiens_hsa051440.85451483
97Bladder cancer_Homo sapiens_hsa052190.85283823
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85160749
99Lysine degradation_Homo sapiens_hsa003100.79608408
100Dopaminergic synapse_Homo sapiens_hsa047280.79433340
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79256916
102Vitamin digestion and absorption_Homo sapiens_hsa049770.78757449
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75445650
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74684271
105Axon guidance_Homo sapiens_hsa043600.73123323
106N-Glycan biosynthesis_Homo sapiens_hsa005100.70894431
107Glycerolipid metabolism_Homo sapiens_hsa005610.70577280
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70404950
109Tight junction_Homo sapiens_hsa045300.69924034
110Endocytosis_Homo sapiens_hsa041440.69838292
111Rap1 signaling pathway_Homo sapiens_hsa040150.68103960
112Pathways in cancer_Homo sapiens_hsa052000.66462432
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65484888
114Renin secretion_Homo sapiens_hsa049240.65329476
115Small cell lung cancer_Homo sapiens_hsa052220.64529846
116Fatty acid biosynthesis_Homo sapiens_hsa000610.60998381
117Ras signaling pathway_Homo sapiens_hsa040140.60027365
118Gastric acid secretion_Homo sapiens_hsa049710.58792029
119Phagosome_Homo sapiens_hsa041450.54665223
120cAMP signaling pathway_Homo sapiens_hsa040240.54054749
121Cholinergic synapse_Homo sapiens_hsa047250.53671225
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53481359
123One carbon pool by folate_Homo sapiens_hsa006700.53279851
124Glutathione metabolism_Homo sapiens_hsa004800.52593671
125Serotonergic synapse_Homo sapiens_hsa047260.51822203
126Pertussis_Homo sapiens_hsa051330.50715782
127MAPK signaling pathway_Homo sapiens_hsa040100.50664253
128Basal transcription factors_Homo sapiens_hsa030220.49806581
129Taste transduction_Homo sapiens_hsa047420.49525557
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49135651
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48801492
132Pentose phosphate pathway_Homo sapiens_hsa000300.47393012
133Shigellosis_Homo sapiens_hsa051310.46674070
134Morphine addiction_Homo sapiens_hsa050320.46443513
135Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45695503
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.43661376
137Prion diseases_Homo sapiens_hsa050200.42740985
138Metabolic pathways_Homo sapiens_hsa011000.41291376
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40808220
140Cocaine addiction_Homo sapiens_hsa050300.40761588
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40255623
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40082209
143Pyrimidine metabolism_Homo sapiens_hsa002400.37933267
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37856880
145Insulin secretion_Homo sapiens_hsa049110.36446026
146Wnt signaling pathway_Homo sapiens_hsa043100.35278461
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27783037
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.27250504
149Insulin resistance_Homo sapiens_hsa049310.26221161
150Fructose and mannose metabolism_Homo sapiens_hsa000510.21905520
151Galactose metabolism_Homo sapiens_hsa000520.17236650
152Glucagon signaling pathway_Homo sapiens_hsa049220.16883265
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16844401
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.14129759
155Linoleic acid metabolism_Homo sapiens_hsa005910.13620138
156Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13273936
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13244621
158AMPK signaling pathway_Homo sapiens_hsa041520.08228932
159Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2467690
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2245336
161Hepatitis C_Homo sapiens_hsa05160-0.2150112
162Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2060147
163Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1969868
164Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1954283
165GABAergic synapse_Homo sapiens_hsa04727-0.1950267
166Amoebiasis_Homo sapiens_hsa05146-0.1857613
167Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1848712
168Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1771237
169Renin-angiotensin system_Homo sapiens_hsa04614-0.1745441
170Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1593155
171Type II diabetes mellitus_Homo sapiens_hsa04930-0.1570202
172African trypanosomiasis_Homo sapiens_hsa05143-0.1473087
173Regulation of autophagy_Homo sapiens_hsa04140-0.1353374
174Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1334556
175Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1050982
176Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0748996
177Insulin signaling pathway_Homo sapiens_hsa04910-0.0372230
178Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0226087

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »