PRR19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex assembly (GO:0007130)8.30462643
2synaptonemal complex organization (GO:0070193)8.04782783
3DNA methylation involved in gamete generation (GO:0043046)8.03697807
4male meiosis (GO:0007140)7.93038206
5sperm motility (GO:0030317)7.09908583
6fusion of sperm to egg plasma membrane (GO:0007342)6.99858472
7cilium or flagellum-dependent cell motility (GO:0001539)6.78009557
8sperm-egg recognition (GO:0035036)6.65832408
9binding of sperm to zona pellucida (GO:0007339)6.53693521
10behavioral response to nicotine (GO:0035095)6.51121430
11spermatid development (GO:0007286)6.12458776
12chromosome organization involved in meiosis (GO:0070192)5.99556338
13male meiosis I (GO:0007141)5.96116963
14cell-cell recognition (GO:0009988)5.93838338
15axonemal dynein complex assembly (GO:0070286)5.91773850
16meiotic nuclear division (GO:0007126)5.91727919
17acrosome assembly (GO:0001675)5.64681203
18acrosome reaction (GO:0007340)5.61133695
19multicellular organism reproduction (GO:0032504)5.35808353
20regulation of meiosis I (GO:0060631)5.30767462
21meiosis I (GO:0007127)5.30164840
22motile cilium assembly (GO:0044458)5.21573393
23epithelial cilium movement (GO:0003351)5.18773715
24plasma membrane fusion (GO:0045026)5.15542548
25regulation of cilium movement (GO:0003352)4.88400918
26microtubule depolymerization (GO:0007019)4.77572969
27L-fucose catabolic process (GO:0042355)4.77294279
28fucose catabolic process (GO:0019317)4.77294279
29L-fucose metabolic process (GO:0042354)4.77294279
30cell wall macromolecule metabolic process (GO:0044036)4.76363222
31cell wall macromolecule catabolic process (GO:0016998)4.76363222
32gene silencing by RNA (GO:0031047)4.62098078
33water-soluble vitamin biosynthetic process (GO:0042364)4.51241131
34spermatogenesis (GO:0007283)4.44255129
35male gamete generation (GO:0048232)4.43619217
36reproduction (GO:0000003)4.38210086
37meiotic cell cycle process (GO:1903046)4.35912130
38cilium movement (GO:0003341)4.30896671
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29944648
40germ cell development (GO:0007281)4.27117903
41negative regulation of telomere maintenance (GO:0032205)4.26411470
42gamete generation (GO:0007276)4.09844792
43meiotic cell cycle (GO:0051321)4.09416540
44DNA deamination (GO:0045006)4.07328764
45rRNA catabolic process (GO:0016075)3.98942812
46chaperone-mediated protein complex assembly (GO:0051131)3.95939286
47nuclear pore organization (GO:0006999)3.93895780
48DNA alkylation (GO:0006305)3.92839667
49DNA methylation (GO:0006306)3.92839667
50fertilization (GO:0009566)3.90244686
51response to pheromone (GO:0019236)3.89937000
52nuclear pore complex assembly (GO:0051292)3.88575651
53kynurenine metabolic process (GO:0070189)3.87768007
54DNA packaging (GO:0006323)3.86759335
55chromosome condensation (GO:0030261)3.84222075
56DNA replication-dependent nucleosome organization (GO:0034723)3.83484747
57DNA replication-dependent nucleosome assembly (GO:0006335)3.83484747
58single fertilization (GO:0007338)3.77795607
59cellular process involved in reproduction in multicellular organism (GO:0022412)3.77231932
60tryptophan catabolic process (GO:0006569)3.76761843
61indole-containing compound catabolic process (GO:0042436)3.76761843
62indolalkylamine catabolic process (GO:0046218)3.76761843
63negative regulation of inclusion body assembly (GO:0090084)3.75516427
64synapsis (GO:0007129)3.61839898
65gene silencing (GO:0016458)3.54365227
66regulation of spindle checkpoint (GO:0090231)3.46313449
67reciprocal meiotic recombination (GO:0007131)3.44951006
68reciprocal DNA recombination (GO:0035825)3.44951006
69regulation of centriole replication (GO:0046599)3.43764891
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42584816
71histone exchange (GO:0043486)3.41609657
72indolalkylamine metabolic process (GO:0006586)3.40743415
73regulation of inclusion body assembly (GO:0090083)3.39322533
74protein localization to chromosome, centromeric region (GO:0071459)3.35479117
75cellular ketone body metabolic process (GO:0046950)3.35394393
76heterochromatin organization (GO:0070828)3.35279212
77attachment of spindle microtubules to kinetochore (GO:0008608)3.31456362
78mitotic sister chromatid cohesion (GO:0007064)3.30351959
79regulation of histone H3-K9 methylation (GO:0051570)3.27430250
80respiratory chain complex IV assembly (GO:0008535)3.27425426
81mitotic nuclear envelope disassembly (GO:0007077)3.27088233
82protein polyglutamylation (GO:0018095)3.26607185
83detection of light stimulus involved in visual perception (GO:0050908)3.23636346
84detection of light stimulus involved in sensory perception (GO:0050962)3.23636346
85single strand break repair (GO:0000012)3.22733404
86mitotic metaphase plate congression (GO:0007080)3.21753888
87meiotic chromosome segregation (GO:0045132)3.18306456
88protein complex biogenesis (GO:0070271)3.18063545
89multicellular organismal reproductive process (GO:0048609)3.17731858
90sperm capacitation (GO:0048240)3.17026506
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15666080
92histone H2A acetylation (GO:0043968)3.15132151
93regulation of chromosome segregation (GO:0051983)3.13757569
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.13148903
95ubiquinone biosynthetic process (GO:0006744)3.12320578
96preassembly of GPI anchor in ER membrane (GO:0016254)3.11510721
97DNA methylation or demethylation (GO:0044728)3.11324700
98gamma-aminobutyric acid transport (GO:0015812)3.10983520
99purine nucleobase biosynthetic process (GO:0009113)3.10777663
100tryptophan metabolic process (GO:0006568)3.10019198
101oogenesis (GO:0048477)3.09534404
102protein localization to cilium (GO:0061512)3.08812347
103seminiferous tubule development (GO:0072520)3.08063988
104protein K6-linked ubiquitination (GO:0085020)3.07681074
105nuclear envelope disassembly (GO:0051081)3.07628720
106membrane disassembly (GO:0030397)3.07628720
107mitochondrial respiratory chain complex I assembly (GO:0032981)3.07312813
108NADH dehydrogenase complex assembly (GO:0010257)3.07312813
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07312813
110sister chromatid cohesion (GO:0007062)3.07212085
111protein complex localization (GO:0031503)3.06007052
112platelet dense granule organization (GO:0060155)3.05846651
113establishment of protein localization to mitochondrial membrane (GO:0090151)3.05275586
114pore complex assembly (GO:0046931)3.03321090
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03256313
116auditory receptor cell stereocilium organization (GO:0060088)3.00568149
117blastocyst development (GO:0001824)2.99290984
118regulation of microtubule-based movement (GO:0060632)2.98792329
119mannosylation (GO:0097502)2.97649208
120mitochondrial respiratory chain complex assembly (GO:0033108)2.96563079
121negative regulation of mast cell activation (GO:0033004)2.96560293
122nucleobase biosynthetic process (GO:0046112)2.96039347
123ketone body metabolic process (GO:1902224)2.95619842
124synaptic transmission, cholinergic (GO:0007271)2.95236943
125protein-cofactor linkage (GO:0018065)2.94201111
126nucleus organization (GO:0006997)2.93861492
127chromosome organization (GO:0051276)2.93791543
128ribosome assembly (GO:0042255)2.93386199
129peptidyl-histidine modification (GO:0018202)2.92721986
130negative regulation of chromosome segregation (GO:0051985)2.91999884
131ventricular system development (GO:0021591)2.90762014
132metaphase plate congression (GO:0051310)2.90342047
133regulation of centrosome cycle (GO:0046605)2.90123210
134negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88126704
135negative regulation of sister chromatid segregation (GO:0033046)2.88126704
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.88126704
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88126704
138monoubiquitinated protein deubiquitination (GO:0035520)2.86904226
139sex differentiation (GO:0007548)2.86816022
140ubiquinone metabolic process (GO:0006743)2.86224877
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85959917
142negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83862464
143cytochrome complex assembly (GO:0017004)2.83728396
144DNA replication checkpoint (GO:0000076)2.82038207
145positive regulation of prostaglandin secretion (GO:0032308)2.81948982
146regulation of action potential (GO:0098900)2.80720925
147regulation of hexokinase activity (GO:1903299)2.78750786
148regulation of glucokinase activity (GO:0033131)2.78750786
149photoreceptor cell maintenance (GO:0045494)2.78743917
150iron-sulfur cluster assembly (GO:0016226)2.78260515
151metallo-sulfur cluster assembly (GO:0031163)2.78260515
152regulation of mesoderm development (GO:2000380)2.78070371
153indole-containing compound metabolic process (GO:0042430)2.74962317
154positive regulation of fatty acid transport (GO:2000193)2.73854899
155retinal cone cell development (GO:0046549)2.73559672
156pseudouridine synthesis (GO:0001522)2.73441102
157sulfation (GO:0051923)2.70746863
158amine catabolic process (GO:0009310)2.70076224
159cellular biogenic amine catabolic process (GO:0042402)2.70076224
160tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69730233
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69730233
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65858576
163axoneme assembly (GO:0035082)2.65513610
164regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65220698
165replication fork processing (GO:0031297)2.62410390
166adaptation of signaling pathway (GO:0023058)2.62106058
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59816864
168neuronal action potential (GO:0019228)2.58851062
169inner ear receptor stereocilium organization (GO:0060122)2.57294536
170fucosylation (GO:0036065)2.57251267
171rhodopsin mediated signaling pathway (GO:0016056)2.56870354
172nonmotile primary cilium assembly (GO:0035058)2.56078612
173proline transport (GO:0015824)2.53886493
174primary amino compound metabolic process (GO:1901160)2.52914443
175transmission of nerve impulse (GO:0019226)2.51783606
176behavioral response to ethanol (GO:0048149)2.50769072
177cellular response to ATP (GO:0071318)2.50241219
178cilium morphogenesis (GO:0060271)2.49178958
179negative regulation of reactive oxygen species metabolic process (GO:2000378)2.49149235
180ncRNA catabolic process (GO:0034661)2.48931873
181nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47855776
182recombinational repair (GO:0000725)2.47254598
183regulation of telomere maintenance (GO:0032204)2.46853741
184reflex (GO:0060004)2.46072604
185somatic hypermutation of immunoglobulin genes (GO:0016446)2.44901748
186somatic diversification of immune receptors via somatic mutation (GO:0002566)2.44901748
187double-strand break repair via homologous recombination (GO:0000724)2.43624497
188cornea development in camera-type eye (GO:0061303)2.43574394
189kidney morphogenesis (GO:0060993)2.43558094
190glycerophospholipid catabolic process (GO:0046475)2.43288700
191piRNA metabolic process (GO:0034587)10.7530958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.61159208
2E2F7_22180533_ChIP-Seq_HELA_Human5.19284351
3ZNF274_21170338_ChIP-Seq_K562_Hela4.34534177
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.64060985
5VDR_22108803_ChIP-Seq_LS180_Human3.49686399
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.19730670
7EZH2_22144423_ChIP-Seq_EOC_Human3.08260813
8GBX2_23144817_ChIP-Seq_PC3_Human2.92826192
9IGF1R_20145208_ChIP-Seq_DFB_Human2.75649469
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72323009
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.65436963
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63283265
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55942712
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53967585
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50984188
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48242031
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40240232
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.39545407
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.38961173
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38841410
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.34885804
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31505599
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25082441
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.24963664
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13156347
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09499338
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08762025
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08453654
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05502662
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98646774
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97017063
32EWS_26573619_Chip-Seq_HEK293_Human1.95413069
33AR_21909140_ChIP-Seq_LNCAP_Human1.93610792
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93253936
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91371776
36TAF15_26573619_Chip-Seq_HEK293_Human1.91365304
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.90103823
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89770527
39FUS_26573619_Chip-Seq_HEK293_Human1.89050581
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.87184859
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.87151865
42P300_19829295_ChIP-Seq_ESCs_Human1.86632860
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86515610
44IRF1_19129219_ChIP-ChIP_H3396_Human1.86219224
45XRN2_22483619_ChIP-Seq_HELA_Human1.83351522
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78708838
47TP53_22573176_ChIP-Seq_HFKS_Human1.78529121
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78079700
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77281800
50ER_23166858_ChIP-Seq_MCF-7_Human1.74236668
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71571781
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69780481
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.63786173
54* VDR_23849224_ChIP-Seq_CD4+_Human1.61622732
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61561487
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58372927
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56920001
58GABP_19822575_ChIP-Seq_HepG2_Human1.55988481
59BCAT_22108803_ChIP-Seq_LS180_Human1.53409623
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53114337
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51033314
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50031828
63REST_21632747_ChIP-Seq_MESCs_Mouse1.48110281
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47698747
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47256620
66MYC_18940864_ChIP-ChIP_HL60_Human1.46831582
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45409474
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.45048515
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44977208
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43796185
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42627535
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42251624
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.42251624
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42106475
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41772024
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41772024
77KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41772024
78NANOG_19829295_ChIP-Seq_ESCs_Human1.41409940
79SOX2_19829295_ChIP-Seq_ESCs_Human1.41409940
80DCP1A_22483619_ChIP-Seq_HELA_Human1.40859473
81AR_25329375_ChIP-Seq_VCAP_Human1.39369867
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.38876653
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36303784
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35005794
85FOXP3_21729870_ChIP-Seq_TREG_Human1.34588821
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.33891128
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33811161
88CBP_20019798_ChIP-Seq_JUKART_Human1.33811161
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32801461
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32593470
91STAT3_23295773_ChIP-Seq_U87_Human1.31415991
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30377021
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28872341
94TCF4_23295773_ChIP-Seq_U87_Human1.28840411
95NCOR_22424771_ChIP-Seq_293T_Human1.28647700
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28603532
97KDM5A_27292631_Chip-Seq_BREAST_Human1.28589907
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.27277987
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26482929
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25943554
101SMAD4_21799915_ChIP-Seq_A2780_Human1.25881918
102HOXB7_26014856_ChIP-Seq_BT474_Human1.25779794
103YY1_22570637_ChIP-Seq_MALME-3M_Human1.25137185
104TTF2_22483619_ChIP-Seq_HELA_Human1.24448256
105THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24081387
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23734683
107AR_20517297_ChIP-Seq_VCAP_Human1.21780823
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21571365
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21511146
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21034403
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20654371
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.20630870
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18694227
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18567637
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18481234
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18180170
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18128670
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17462705
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17290970
120RNF2_27304074_Chip-Seq_NSC_Mouse1.17197530
121TCF4_22108803_ChIP-Seq_LS180_Human1.17141837
122RUNX2_22187159_ChIP-Seq_PCA_Human1.16501158
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15924885
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14807795
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14373157
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13914161
127MYC_19829295_ChIP-Seq_ESCs_Human1.13287629
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.13185058
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12021242
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11445559
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11445559
132SMAD4_21741376_ChIP-Seq_EPCs_Human1.10818094
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.09979379
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08178219
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08031631
136ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07828935
137KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07207197
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06700747
139FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06532380
140ERA_21632823_ChIP-Seq_H3396_Human1.06361687
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05902493
142EZH2_27294783_Chip-Seq_NPCs_Mouse1.05439558
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05099236
144ELK1_19687146_ChIP-ChIP_HELA_Human1.04425062
145AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04326221
146FOXH1_21741376_ChIP-Seq_EPCs_Human1.03940621
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03056713
148NANOG_20526341_ChIP-Seq_ESCs_Human1.02907237
149PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01580065
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00087761
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99861480
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99182542
153REST_18959480_ChIP-ChIP_MESCs_Mouse0.98767127
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.98569015
155TAF2_19829295_ChIP-Seq_ESCs_Human0.98418723
156OCT4_20526341_ChIP-Seq_ESCs_Human0.96555529
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95221938
158GATA3_21867929_ChIP-Seq_CD8_Mouse0.93391010
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93171242
160FLI1_21867929_ChIP-Seq_TH2_Mouse0.93036691
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92564648
162EZH2_27304074_Chip-Seq_ESCs_Mouse0.92508354
163CIITA_25753668_ChIP-Seq_RAJI_Human0.91605806
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90863142
165PHF8_20622854_ChIP-Seq_HELA_Human0.89738762
166ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89535515
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.87634328
168SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86657033
169FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86173484
170SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84503719
171POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81355739
172CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80419000
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.80269096
174RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80034968
175FOXP1_21924763_ChIP-Seq_HESCs_Human0.79229358
176TET1_21451524_ChIP-Seq_MESCs_Mouse0.78823992
177* RARA_24833708_ChIP-Seq_LIVER_Mouse0.77909607
178FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77254040
179POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76249710
180BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76214106
181CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75882690
182E2F1_20622854_ChIP-Seq_HELA_Human0.75607591
183CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75049929
184SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.74801607
185SRF_21415370_ChIP-Seq_HL-1_Mouse0.72508449
186ELK4_26923725_Chip-Seq_MESODERM_Mouse0.72070671
187RUNX1_26923725_Chip-Seq_HPCs_Mouse0.71920994
188CTCF_26484167_Chip-Seq_Bcells_Mouse0.71459904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.65100093
2MP0008877_abnormal_DNA_methylation7.37128532
3MP0001929_abnormal_gametogenesis4.58659557
4MP0003698_abnormal_male_reproductive4.37987117
5MP0002210_abnormal_sex_determination3.98089731
6MP0003693_abnormal_embryo_hatching3.59309539
7MP0003111_abnormal_nucleus_morphology3.54793927
8MP0010094_abnormal_chromosome_stability3.53873915
9MP0001145_abnormal_male_reproductive3.34771015
10MP0008058_abnormal_DNA_repair3.26917201
11MP0000653_abnormal_sex_gland2.91920440
12MP0004957_abnormal_blastocyst_morpholog2.90737808
13MP0008057_abnormal_DNA_replication2.86683916
14MP0003077_abnormal_cell_cycle2.71805029
15MP0003195_calcinosis2.71572344
16MP0008995_early_reproductive_senescence2.64779492
17MP0003786_premature_aging2.58623215
18MP0002161_abnormal_fertility/fecundity2.57049387
19MP0002653_abnormal_ependyma_morphology2.51181996
20MP0005551_abnormal_eye_electrophysiolog2.49785374
21MP0001968_abnormal_touch/_nociception2.37424371
22MP0009046_muscle_twitch2.18806940
23MP0002837_dystrophic_cardiac_calcinosis2.16922652
24MP0006072_abnormal_retinal_apoptosis2.12836481
25MP0003011_delayed_dark_adaptation2.11396034
26MP0000427_abnormal_hair_cycle2.11177308
27MP0000569_abnormal_digit_pigmentation2.05706779
28MP0001986_abnormal_taste_sensitivity1.99932876
29MP0008007_abnormal_cellular_replicative1.99796341
30MP0002876_abnormal_thyroid_physiology1.99523232
31MP0001730_embryonic_growth_arrest1.98563998
32MP0002736_abnormal_nociception_after1.97439233
33MP0004142_abnormal_muscle_tone1.96767945
34MP0008875_abnormal_xenobiotic_pharmacok1.94011970
35MP0008872_abnormal_physiological_respon1.90281578
36MP0002160_abnormal_reproductive_system1.89882721
37MP0009745_abnormal_behavioral_response1.89096586
38MP0003123_paternal_imprinting1.82142062
39MP0004885_abnormal_endolymph1.80349238
40MP0005670_abnormal_white_adipose1.80093393
41MP0005253_abnormal_eye_physiology1.78639052
42MP0008932_abnormal_embryonic_tissue1.77776253
43MP0003880_abnormal_central_pattern1.76724685
44MP0005084_abnormal_gallbladder_morpholo1.76425051
45MP0005646_abnormal_pituitary_gland1.76300456
46MP0003787_abnormal_imprinting1.74777458
47MP0004147_increased_porphyrin_level1.74731105
48MP0006276_abnormal_autonomic_nervous1.73700626
49MP0003718_maternal_effect1.71265033
50MP0005645_abnormal_hypothalamus_physiol1.69739793
51MP0002272_abnormal_nervous_system1.68413766
52MP0001501_abnormal_sleep_pattern1.58587403
53MP0002163_abnormal_gland_morphology1.56684030
54MP0000372_irregular_coat_pigmentation1.53307074
55MP0004043_abnormal_pH_regulation1.47098601
56MP0004145_abnormal_muscle_electrophysio1.46409586
57MP0000631_abnormal_neuroendocrine_gland1.44155528
58MP0004742_abnormal_vestibular_system1.43611820
59MP0002938_white_spotting1.41115891
60MP0005623_abnormal_meninges_morphology1.41007676
61MP0003878_abnormal_ear_physiology1.40073918
62MP0005377_hearing/vestibular/ear_phenot1.40073918
63MP0003136_yellow_coat_color1.39831391
64MP0002638_abnormal_pupillary_reflex1.38371104
65MP0001485_abnormal_pinna_reflex1.37866062
66MP0000350_abnormal_cell_proliferation1.37742094
67MP0010386_abnormal_urinary_bladder1.36939330
68MP0005380_embryogenesis_phenotype1.36522912
69MP0001672_abnormal_embryogenesis/_devel1.36522912
70MP0005379_endocrine/exocrine_gland_phen1.33551080
71MP0010307_abnormal_tumor_latency1.32957428
72MP0002733_abnormal_thermal_nociception1.30379271
73MP0001529_abnormal_vocalization1.29725129
74MP0002064_seizures1.29655189
75MP0003646_muscle_fatigue1.29287576
76MP0002735_abnormal_chemical_nociception1.27907393
77MP0001486_abnormal_startle_reflex1.25798685
78MP0002572_abnormal_emotion/affect_behav1.25776022
79MP0009697_abnormal_copulation1.24623551
80MP0002138_abnormal_hepatobiliary_system1.24223050
81MP0001697_abnormal_embryo_size1.23467515
82MP0002928_abnormal_bile_duct1.22306161
83MP0001970_abnormal_pain_threshold1.21756036
84MP0002085_abnormal_embryonic_tissue1.18385060
85MP0003984_embryonic_growth_retardation1.17180034
86MP0005389_reproductive_system_phenotype1.17062410
87MP0002080_prenatal_lethality1.14077531
88MP0001661_extended_life_span1.12133887
89MP0002088_abnormal_embryonic_growth/wei1.12070812
90MP0002084_abnormal_developmental_patter1.11797194
91MP0001984_abnormal_olfaction1.10130812
92MP0000383_abnormal_hair_follicle1.09182597
93MP0002557_abnormal_social/conspecific_i1.09144946
94MP0005174_abnormal_tail_pigmentation1.07116351
95MP0005085_abnormal_gallbladder_physiolo1.05796954
96MP0001905_abnormal_dopamine_level1.05432810
97MP0003315_abnormal_perineum_morphology1.05314195
98MP0005423_abnormal_somatic_nervous1.03666611
99MP0001119_abnormal_female_reproductive1.03071636
100MP0000313_abnormal_cell_death1.02366619
101MP0005195_abnormal_posterior_eye1.01040153
102MP0004233_abnormal_muscle_weight1.00922251
103MP0005386_behavior/neurological_phenoty1.00496155
104MP0004924_abnormal_behavior1.00496155
105MP0003252_abnormal_bile_duct1.00170877
106MP0002095_abnormal_skin_pigmentation0.98601908
107MP0004197_abnormal_fetal_growth/weight/0.98484656
108MP0000230_abnormal_systemic_arterial0.98241624
109MP0001293_anophthalmia0.97209408
110MP0002067_abnormal_sensory_capabilities0.97174718
111MP0003635_abnormal_synaptic_transmissio0.96217043
112MP0005075_abnormal_melanosome_morpholog0.96177764
113MP0003890_abnormal_embryonic-extraembry0.93809458
114MP0000647_abnormal_sebaceous_gland0.92205231
115MP0005332_abnormal_amino_acid0.91088535
116MP0003122_maternal_imprinting0.90219314
117MP0003941_abnormal_skin_development0.90153541
118MP0002184_abnormal_innervation0.90132526
119MP0003699_abnormal_female_reproductive0.89644371
120MP0000358_abnormal_cell_content/0.89592670
121MP0002063_abnormal_learning/memory/cond0.89542565
122MP0003283_abnormal_digestive_organ0.89192288
123MP0004215_abnormal_myocardial_fiber0.88646298
124MP0008775_abnormal_heart_ventricle0.87821813
125MP0004133_heterotaxia0.87721135
126MP0002752_abnormal_somatic_nervous0.86653866
127MP0002277_abnormal_respiratory_mucosa0.86427593
128MP0002734_abnormal_mechanical_nocicepti0.84992666
129MP0001963_abnormal_hearing_physiology0.84862113
130MP0002751_abnormal_autonomic_nervous0.84482690
131MP0008789_abnormal_olfactory_epithelium0.84035996
132MP0003137_abnormal_impulse_conducting0.82715441
133MP0010352_gastrointestinal_tract_polyps0.82270179
134MP0002086_abnormal_extraembryonic_tissu0.82124322
135MP0002693_abnormal_pancreas_physiology0.81438776
136MP0003119_abnormal_digestive_system0.81189907
137MP0005167_abnormal_blood-brain_barrier0.78190708
138MP0009672_abnormal_birth_weight0.77021652
139MP0000537_abnormal_urethra_morphology0.71173307
140MP0003936_abnormal_reproductive_system0.70681741
141MP0004808_abnormal_hematopoietic_stem0.68188332
142MP0003115_abnormal_respiratory_system0.67572085
143MP0002019_abnormal_tumor_incidence0.66581369
144MP0003121_genomic_imprinting0.65720438
145MP0005076_abnormal_cell_differentiation0.65325102
146MP0001545_abnormal_hematopoietic_system0.63707202
147MP0005397_hematopoietic_system_phenotyp0.63707202
148MP0008260_abnormal_autophagy0.61871740
149MP0005395_other_phenotype0.61606502
150MP0003861_abnormal_nervous_system0.60180722
151MP0002269_muscular_atrophy0.59518890
152MP0010030_abnormal_orbit_morphology0.56411840
153MP0009703_decreased_birth_body0.56040484
154MP0002282_abnormal_trachea_morphology0.56003573
155MP0005384_cellular_phenotype0.54999889
156MP0001727_abnormal_embryo_implantation0.54128892
157MP0005647_abnormal_sex_gland0.52654021
158MP0009278_abnormal_bone_marrow0.51390792
159MP0006035_abnormal_mitochondrial_morpho0.51055984
160MP0006036_abnormal_mitochondrial_physio0.49413697
161MP0003937_abnormal_limbs/digits/tail_de0.49174453
162MP0005621_abnormal_cell_physiology0.49020748
163MP0001915_intracranial_hemorrhage0.48994119
164MP0003806_abnormal_nucleotide_metabolis0.48791961
165MP0002092_abnormal_eye_morphology0.48604394
166MP0002234_abnormal_pharynx_morphology0.47556203
167MP0003221_abnormal_cardiomyocyte_apopto0.46557901
168MP0003567_abnormal_fetal_cardiomyocyte0.45221703
169MP0000534_abnormal_ureter_morphology0.41733811
170MP0001919_abnormal_reproductive_system0.40373840
171MP0000432_abnormal_head_morphology0.40115801
172MP0005666_abnormal_adipose_tissue0.38318430
173MP0003879_abnormal_hair_cell0.36295776
174MP0005391_vision/eye_phenotype0.36190811
175MP0001849_ear_inflammation0.35149545
176MP0002102_abnormal_ear_morphology0.34751927
177MP0006292_abnormal_olfactory_placode0.33502036
178MP0000750_abnormal_muscle_regeneration0.32571762
179MP0000428_abnormal_craniofacial_morphol0.31914934
180MP0009053_abnormal_anal_canal0.30532684
181MP0002111_abnormal_tail_morphology0.30280275
182MP0002114_abnormal_axial_skeleton0.29134216

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.55970289
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.07983067
3Absent/shortened dynein arms (HP:0200106)9.07983067
4Abnormal respiratory epithelium morphology (HP:0012253)6.57810073
5Abnormal respiratory motile cilium morphology (HP:0005938)6.57810073
6Abnormal respiratory motile cilium physiology (HP:0012261)6.46946548
7Rhinitis (HP:0012384)5.64218833
8Chronic bronchitis (HP:0004469)5.63281504
9Abnormal spermatogenesis (HP:0008669)5.55015045
10Infertility (HP:0000789)5.14736788
11Abnormal ciliary motility (HP:0012262)4.88206657
12Azoospermia (HP:0000027)4.72636404
13Impulsivity (HP:0100710)4.49494660
14Pancreatic cysts (HP:0001737)4.40564160
15Nasal polyposis (HP:0100582)4.07154896
16Pancreatic fibrosis (HP:0100732)3.94043376
17Male infertility (HP:0003251)3.89812850
18Gonadotropin excess (HP:0000837)3.88999864
19Congenital stationary night blindness (HP:0007642)3.85052809
20Abnormality of the lower motor neuron (HP:0002366)3.70070340
21True hermaphroditism (HP:0010459)3.65137595
22Type II lissencephaly (HP:0007260)3.44320439
23Bronchitis (HP:0012387)3.28894651
24Nephronophthisis (HP:0000090)3.25381210
25Abnormality of the renal cortex (HP:0011035)3.25214842
26Bronchiectasis (HP:0002110)3.24108082
27Abnormality of the nasal mucosa (HP:0000433)3.22033554
28Degeneration of anterior horn cells (HP:0002398)3.14951678
29Abnormality of the anterior horn cell (HP:0006802)3.14951678
30Carpal bone hypoplasia (HP:0001498)3.12685090
31Medial flaring of the eyebrow (HP:0010747)3.08096778
32Inability to walk (HP:0002540)2.95605529
33Supernumerary spleens (HP:0009799)2.95509398
34Attenuation of retinal blood vessels (HP:0007843)2.84144395
35Abolished electroretinogram (ERG) (HP:0000550)2.82653765
36Amyotrophic lateral sclerosis (HP:0007354)2.82090966
37Progressive inability to walk (HP:0002505)2.81195163
38Cystic liver disease (HP:0006706)2.72829321
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.70379393
40Hypoplasia of the fovea (HP:0007750)2.70379393
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.68071952
42Hyperventilation (HP:0002883)2.64421082
43Renal cortical cysts (HP:0000803)2.63498367
44Breast hypoplasia (HP:0003187)2.63417376
45Facial cleft (HP:0002006)2.58982954
46Cerebellar dysplasia (HP:0007033)2.58820429
47Selective tooth agenesis (HP:0001592)2.58190819
48Lissencephaly (HP:0001339)2.57384189
49Concave nail (HP:0001598)2.56489899
50Bilateral microphthalmos (HP:0007633)2.49101956
51Abnormality of alanine metabolism (HP:0010916)2.47924427
52Hyperalaninemia (HP:0003348)2.47924427
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47924427
54Fibular aplasia (HP:0002990)2.47626772
55Sclerocornea (HP:0000647)2.46694424
56Gait imbalance (HP:0002141)2.46248011
57Pendular nystagmus (HP:0012043)2.45407263
58Mitochondrial inheritance (HP:0001427)2.44914524
59Recurrent otitis media (HP:0000403)2.44423002
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42998657
61Chromsome breakage (HP:0040012)2.42898868
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41441835
63Increased CSF lactate (HP:0002490)2.39468581
64Meckel diverticulum (HP:0002245)2.39322640
65Acute necrotizing encephalopathy (HP:0006965)2.38899699
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38259917
67Congenital primary aphakia (HP:0007707)2.38066821
68Absent thumb (HP:0009777)2.37256114
69Polydipsia (HP:0001959)2.35718878
70Abnormal drinking behavior (HP:0030082)2.35718878
71Chronic hepatic failure (HP:0100626)2.31067590
72Nephrogenic diabetes insipidus (HP:0009806)2.29951433
73Partial agenesis of the corpus callosum (HP:0001338)2.29589945
74Abnormality of the renal medulla (HP:0100957)2.26766469
75Decreased circulating renin level (HP:0003351)2.25925253
76Abnormality of the pons (HP:0007361)2.25501436
77Hyperglycinuria (HP:0003108)2.24394238
78Acute encephalopathy (HP:0006846)2.24146040
79Congenital, generalized hypertrichosis (HP:0004540)2.23504165
80Abnormality of the ileum (HP:0001549)2.22981414
81Abnormal rod and cone electroretinograms (HP:0008323)2.22593706
82Atrophy/Degeneration involving motor neurons (HP:0007373)2.21831635
83Severe muscular hypotonia (HP:0006829)2.21539166
84Abnormality of the preputium (HP:0100587)2.19996564
85Hypoplasia of the pons (HP:0012110)2.19718735
86Abnormality of the fovea (HP:0000493)2.19662201
87Abnormality of chromosome stability (HP:0003220)2.18909498
883-Methylglutaconic aciduria (HP:0003535)2.18890112
89Hepatic necrosis (HP:0002605)2.18539703
90Large for gestational age (HP:0001520)2.15235706
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15168427
92Hemiparesis (HP:0001269)2.15012205
93Lipid accumulation in hepatocytes (HP:0006561)2.14911456
94Cerebral hypomyelination (HP:0006808)2.14598917
95Decreased central vision (HP:0007663)2.14420509
9611 pairs of ribs (HP:0000878)2.14027520
97Ectopic kidney (HP:0000086)2.13428136
98Hepatocellular necrosis (HP:0001404)2.12744664
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.11878324
100Premature ovarian failure (HP:0008209)2.10326932
101Increased corneal curvature (HP:0100692)2.10267960
102Keratoconus (HP:0000563)2.10267960
103Anencephaly (HP:0002323)2.07310173
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.06248222
105Abnormal mitochondria in muscle tissue (HP:0008316)2.06171190
106Absent radius (HP:0003974)2.05227795
107Medulloblastoma (HP:0002885)2.04663343
108Progressive macrocephaly (HP:0004481)2.04125683
109Birth length less than 3rd percentile (HP:0003561)2.04069358
110Absent epiphyses (HP:0010577)2.03221329
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03221329
112Upper motor neuron abnormality (HP:0002127)2.02842816
113Fibular hypoplasia (HP:0003038)2.01882798
114Aplasia/hypoplasia of the uterus (HP:0008684)2.01805440
115Furrowed tongue (HP:0000221)2.01575092
116Ependymoma (HP:0002888)2.00031174
117Methylmalonic aciduria (HP:0012120)1.99798927
118Methylmalonic acidemia (HP:0002912)1.99630926
119Pachygyria (HP:0001302)1.98844834
120Optic disc pallor (HP:0000543)1.98749777
121Tubulointerstitial nephritis (HP:0001970)1.97014441
122Male pseudohermaphroditism (HP:0000037)1.96648072
123Sloping forehead (HP:0000340)1.95505147
124Aplasia/hypoplasia of the humerus (HP:0006507)1.95264992
125Abnormal biliary tract physiology (HP:0012439)1.95192954
126Bile duct proliferation (HP:0001408)1.95192954
127Recurrent sinusitis (HP:0011108)1.94801730
128Short ribs (HP:0000773)1.94340173
129Hyperglycinemia (HP:0002154)1.94107196
130Abnormality of serine family amino acid metabolism (HP:0010894)1.93930651
131Abnormality of glycine metabolism (HP:0010895)1.93930651
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.93904977
133Disproportionate short-trunk short stature (HP:0003521)1.93365330
134Gaze-evoked nystagmus (HP:0000640)1.92659513
135Abnormality of midbrain morphology (HP:0002418)1.92211060
136Molar tooth sign on MRI (HP:0002419)1.92211060
137Aplasia involving forearm bones (HP:0009822)1.91992792
138Absent forearm bone (HP:0003953)1.91992792
139Increased serum lactate (HP:0002151)1.90685290
140Congenital hepatic fibrosis (HP:0002612)1.90420665
141Stomach cancer (HP:0012126)1.90178808
142Broad-based gait (HP:0002136)1.89999078
143Bony spicule pigmentary retinopathy (HP:0007737)1.89726084
144Tubular atrophy (HP:0000092)1.89398288
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88989319
146Progressive cerebellar ataxia (HP:0002073)1.88803276
147Genital tract atresia (HP:0001827)1.88608211
148Polyuria (HP:0000103)1.86531304
149Vaginal atresia (HP:0000148)1.84631715
150Rough bone trabeculation (HP:0100670)1.83240601
151Abnormality of abdominal situs (HP:0011620)1.83206402
152Abdominal situs inversus (HP:0003363)1.83206402
153Chorioretinal atrophy (HP:0000533)1.82450468
154Small intestinal stenosis (HP:0012848)1.82144614
155Duodenal stenosis (HP:0100867)1.82144614
156Hypothermia (HP:0002045)1.81797058
157Heterotopia (HP:0002282)1.80308400
158Retinal dysplasia (HP:0007973)1.78961377
159Clumsiness (HP:0002312)1.78616057
160Increased hepatocellular lipid droplets (HP:0006565)1.78408455
161Personality changes (HP:0000751)1.78343422
162Cleft eyelid (HP:0000625)1.77386017
163Spastic tetraparesis (HP:0001285)1.74434591
164Patellar aplasia (HP:0006443)1.74097137
165Hypoplasia of the radius (HP:0002984)1.72779291
166Recurrent bronchitis (HP:0002837)1.72636748
167Median cleft lip (HP:0000161)1.71884269
168Postaxial foot polydactyly (HP:0001830)1.71189156
169Colon cancer (HP:0003003)1.70422841
170Horseshoe kidney (HP:0000085)1.69263361
171Short humerus (HP:0005792)1.67721584
172Secondary amenorrhea (HP:0000869)1.67466838
173Aplasia/Hypoplasia of the patella (HP:0006498)1.67320436
174Abnormality of the labia minora (HP:0012880)1.67114947
175Oligodactyly (HP:0012165)1.65490448
176Reticulocytopenia (HP:0001896)1.65317188
177Abnormal lung lobation (HP:0002101)1.61398090
178Breast carcinoma (HP:0003002)1.61330264
179Spinal muscular atrophy (HP:0007269)1.59788186
180Facial hemangioma (HP:0000329)1.57354066
181Oculomotor apraxia (HP:0000657)1.56861463
182Short thumb (HP:0009778)1.55927324
183Broad distal phalanx of finger (HP:0009836)1.55697016
184Abnormality of the carotid arteries (HP:0005344)1.52948911
185Aplasia/Hypoplasia of the fibula (HP:0006492)1.51336913
186Trismus (HP:0000211)1.51155455
187Squamous cell carcinoma (HP:0002860)1.51088079
188Tubulointerstitial abnormality (HP:0001969)1.49989144
189Ureteral duplication (HP:0000073)1.49916396
190Glioma (HP:0009733)1.49859522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.04605372
2PDK46.04605372
3FRK4.87956649
4TESK14.08005332
5PDK23.92351354
6BUB13.75737130
7PRKD33.26091504
8WEE13.15818166
9CDC73.11852931
10NEK23.02926363
11ICK2.93933317
12ADRBK22.92290428
13NUAK12.73037204
14MAP4K22.65909073
15GRK12.63658688
16PLK42.40930746
17INSRR2.27856927
18TTK2.18777853
19VRK22.16748963
20CDK122.16530207
21PNCK2.11014660
22TXK1.99312262
23ACVR1B1.92594460
24TAOK31.84518798
25EIF2AK11.73596686
26OXSR11.68875485
27PLK11.65893276
28TAF11.61678800
29MAP3K41.60485940
30EPHA21.57985585
31MAPK131.57362413
32DYRK31.56262100
33TSSK61.46623299
34STK161.43509048
35TESK21.38954365
36ATR1.35370545
37TIE11.35014330
38DAPK21.34645547
39CASK1.32554900
40BRSK21.30865684
41CHEK21.27503909
42SRPK11.26724916
43CHEK11.25712468
44PASK1.18858785
45CCNB11.15310949
46CSNK1G31.13478494
47STK38L1.12413957
48TRIM281.11278887
49CSNK1G21.10706367
50CSNK1G11.06671122
51PTK2B1.06434731
52MAP2K71.05447276
53ADRBK11.03880222
54NEK11.03379278
55PLK31.02033690
56BRSK11.00517811
57STK31.00211653
58MAPKAPK50.99376250
59CSNK1A1L0.98211423
60PRKCG0.97290556
61CDK70.96765374
62STK380.96437237
63AURKB0.91369770
64BRD40.90597321
65PRKCE0.89560913
66WNK40.89265697
67ATM0.86963547
68PHKG20.85485639
69PHKG10.85485639
70PAK30.81535397
71AURKA0.81017977
72MUSK0.80460656
73STK390.79741180
74AKT30.79563852
75LIMK10.79459935
76CDK190.77843571
77CAMKK20.74140131
78ZAK0.73294166
79DYRK1B0.72827642
80PAK40.72461450
81TNIK0.70554720
82PLK20.70236343
83CDK40.68532321
84CDK20.68261727
85PRKG20.67904030
86PINK10.67758685
87GRK50.66858870
88EIF2AK30.66308583
89PAK10.66024838
90MTOR0.65673415
91IKBKB0.65295892
92PIK3CA0.63977743
93STK110.60128487
94MAP2K60.59481856
95TYRO30.57010238
96BRAF0.56295711
97PRKCQ0.55897173
98BCR0.55647162
99CDK10.54218799
100MAP3K80.53942331
101RPS6KA40.53703104
102SIK20.51597934
103MKNK20.51309700
104MAP2K20.51087542
105CSNK2A20.48939218
106VRK10.48736948
107IRAK20.48554072
108TEC0.47840221
109CAMK2A0.47273117
110LATS20.46378315
111IRAK10.45088652
112RPS6KB20.44853078
113PRKAA20.44830270
114STK40.44723530
115CSNK1A10.44681767
116CSNK2A10.44218839
117GRK70.43899867
118MKNK10.42888103
119HIPK20.40754983
120ITK0.39992437
121PRKACA0.39315730
122CSNK1E0.38490474
123FLT30.37500958
124BCKDK0.37248799
125MST40.37214858
126KIT0.36359279
127EIF2AK20.36113895
128PRKCA0.34637881
129CAMK10.33643448
130PDK10.32564622
131MAP3K100.32478582
132PRKAA10.32289158
133TLK10.32288221
134PRKDC0.31454055
135DAPK10.30869644
136NLK0.30619523
137EEF2K0.30353399
138MELK0.30120814
139NTRK30.29940115
140PBK0.29238369
141MARK10.28031315
142PRKCI0.27878058
143TGFBR10.26996246
144GSK3B0.25099311
145WNK10.21553057
146STK100.21116175
147PIM10.19973706
148ALK0.19591599
149DYRK20.18879372
150PAK20.18246415
151CSNK1D0.17105658
152WNK30.16974333
153MAPKAPK30.16711302
154IRAK30.16372500
155RPS6KA50.13877668
156MAPK80.13531735
157BMPR1B0.12648446
158MAPK140.12191785
159RPS6KB10.11851222
160RPS6KA10.11192498
161NME10.11180221
162MAPK100.10611926
163MAPK150.10015875

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.27634011
2DNA replication_Homo sapiens_hsa030303.71027552
3RNA transport_Homo sapiens_hsa030133.65723206
4Basal transcription factors_Homo sapiens_hsa030223.62263343
5Vitamin B6 metabolism_Homo sapiens_hsa007503.41625166
6Proteasome_Homo sapiens_hsa030503.37186192
7RNA polymerase_Homo sapiens_hsa030203.34267061
8Mismatch repair_Homo sapiens_hsa034303.28307749
9Spliceosome_Homo sapiens_hsa030402.97958616
10Fanconi anemia pathway_Homo sapiens_hsa034602.82652482
11Phototransduction_Homo sapiens_hsa047442.78621045
12Homologous recombination_Homo sapiens_hsa034402.73119086
13Oxidative phosphorylation_Homo sapiens_hsa001902.50445613
14Nucleotide excision repair_Homo sapiens_hsa034202.48303622
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45330402
16Pyrimidine metabolism_Homo sapiens_hsa002402.39959288
17Cell cycle_Homo sapiens_hsa041102.38404571
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36198264
19mRNA surveillance pathway_Homo sapiens_hsa030152.30935886
20Base excision repair_Homo sapiens_hsa034102.26244576
21Butanoate metabolism_Homo sapiens_hsa006502.23572573
22Nitrogen metabolism_Homo sapiens_hsa009102.17704243
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12249256
24Selenocompound metabolism_Homo sapiens_hsa004502.09736401
25Protein export_Homo sapiens_hsa030602.01665535
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00585748
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96151033
28Parkinsons disease_Homo sapiens_hsa050121.96060255
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95156296
30Nicotine addiction_Homo sapiens_hsa050331.95006631
31Oocyte meiosis_Homo sapiens_hsa041141.94672047
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80280380
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.76986749
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.76897162
35Purine metabolism_Homo sapiens_hsa002301.72763315
36RNA degradation_Homo sapiens_hsa030181.71837500
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71749929
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69993588
39One carbon pool by folate_Homo sapiens_hsa006701.69004944
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62213867
41Tryptophan metabolism_Homo sapiens_hsa003801.61116601
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.60829982
43Pentose phosphate pathway_Homo sapiens_hsa000301.58052691
44Pyruvate metabolism_Homo sapiens_hsa006201.50709516
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48811127
46Ribosome_Homo sapiens_hsa030101.46928501
47Non-homologous end-joining_Homo sapiens_hsa034501.44884160
48Olfactory transduction_Homo sapiens_hsa047401.41602062
49Morphine addiction_Homo sapiens_hsa050321.40317888
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33020912
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.30725708
52p53 signaling pathway_Homo sapiens_hsa041151.24114708
53Caffeine metabolism_Homo sapiens_hsa002321.21537793
54Biosynthesis of amino acids_Homo sapiens_hsa012301.20538839
55Taste transduction_Homo sapiens_hsa047421.20323076
56Fatty acid biosynthesis_Homo sapiens_hsa000611.19410567
57Alzheimers disease_Homo sapiens_hsa050101.19288086
58Epstein-Barr virus infection_Homo sapiens_hsa051691.18639276
59Linoleic acid metabolism_Homo sapiens_hsa005911.17467683
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.15564629
61GABAergic synapse_Homo sapiens_hsa047271.14211377
62Huntingtons disease_Homo sapiens_hsa050161.14000600
63Dorso-ventral axis formation_Homo sapiens_hsa043201.13288443
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11298071
65Chemical carcinogenesis_Homo sapiens_hsa052041.10865543
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10564735
67ABC transporters_Homo sapiens_hsa020101.09331480
68Peroxisome_Homo sapiens_hsa041461.07219553
69Glycerophospholipid metabolism_Homo sapiens_hsa005641.04535098
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04403959
71Circadian entrainment_Homo sapiens_hsa047131.04063717
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02086677
73Insulin secretion_Homo sapiens_hsa049110.98226734
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.96152628
75Sulfur metabolism_Homo sapiens_hsa009200.95705602
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94742795
77Retinol metabolism_Homo sapiens_hsa008300.94510468
78Glycerolipid metabolism_Homo sapiens_hsa005610.93218259
79Fructose and mannose metabolism_Homo sapiens_hsa000510.93118847
80Glucagon signaling pathway_Homo sapiens_hsa049220.92641939
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92317526
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91809186
83Carbon metabolism_Homo sapiens_hsa012000.91682523
84beta-Alanine metabolism_Homo sapiens_hsa004100.85119783
85Serotonergic synapse_Homo sapiens_hsa047260.84676419
86Antigen processing and presentation_Homo sapiens_hsa046120.81289066
87Glutamatergic synapse_Homo sapiens_hsa047240.80422350
88Salivary secretion_Homo sapiens_hsa049700.77672098
89Propanoate metabolism_Homo sapiens_hsa006400.76693030
90Ovarian steroidogenesis_Homo sapiens_hsa049130.74894829
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72903042
92Asthma_Homo sapiens_hsa053100.71517598
93Glutathione metabolism_Homo sapiens_hsa004800.69240599
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67992755
95Collecting duct acid secretion_Homo sapiens_hsa049660.67056922
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63848462
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63727920
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61320684
99Folate biosynthesis_Homo sapiens_hsa007900.61040997
100Primary immunodeficiency_Homo sapiens_hsa053400.60850247
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60763978
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59657866
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58698492
104Viral carcinogenesis_Homo sapiens_hsa052030.58658629
105Systemic lupus erythematosus_Homo sapiens_hsa053220.57713494
106Histidine metabolism_Homo sapiens_hsa003400.57522583
107Calcium signaling pathway_Homo sapiens_hsa040200.57493259
108Fatty acid elongation_Homo sapiens_hsa000620.55598031
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.54046319
110Hedgehog signaling pathway_Homo sapiens_hsa043400.52455657
111Fat digestion and absorption_Homo sapiens_hsa049750.47864831
112Steroid biosynthesis_Homo sapiens_hsa001000.46919665
113Herpes simplex infection_Homo sapiens_hsa051680.46113330
114Type I diabetes mellitus_Homo sapiens_hsa049400.45338813
115Dopaminergic synapse_Homo sapiens_hsa047280.43710379
116Arginine and proline metabolism_Homo sapiens_hsa003300.42600406
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40774732
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40517400
119HTLV-I infection_Homo sapiens_hsa051660.40410796
120Fatty acid degradation_Homo sapiens_hsa000710.40028901
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.39177861
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38250594
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36974728
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.36768279
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35725060
126Metabolic pathways_Homo sapiens_hsa011000.35656892
127Ether lipid metabolism_Homo sapiens_hsa005650.34953945
128Circadian rhythm_Homo sapiens_hsa047100.34738324
129Graft-versus-host disease_Homo sapiens_hsa053320.32847102
130Regulation of autophagy_Homo sapiens_hsa041400.31563704
131Basal cell carcinoma_Homo sapiens_hsa052170.29343050
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27339430
133Vitamin digestion and absorption_Homo sapiens_hsa049770.27043875
134Mineral absorption_Homo sapiens_hsa049780.26722885
135HIF-1 signaling pathway_Homo sapiens_hsa040660.25432298
136Arachidonic acid metabolism_Homo sapiens_hsa005900.25388729
137Legionellosis_Homo sapiens_hsa051340.23997005
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23834127
139Hippo signaling pathway_Homo sapiens_hsa043900.21444078
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19536940
141Tight junction_Homo sapiens_hsa045300.18506312
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17822178
143Cardiac muscle contraction_Homo sapiens_hsa042600.16941034
144Renin-angiotensin system_Homo sapiens_hsa046140.16682821
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15456642
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15165480
147AMPK signaling pathway_Homo sapiens_hsa041520.13774056
148TGF-beta signaling pathway_Homo sapiens_hsa043500.13322682
149Sulfur relay system_Homo sapiens_hsa041220.10819356
150Alcoholism_Homo sapiens_hsa050340.10297948
151Lysine degradation_Homo sapiens_hsa003100.08440894
152Influenza A_Homo sapiens_hsa051640.08132786
153Wnt signaling pathway_Homo sapiens_hsa043100.08020636
154mTOR signaling pathway_Homo sapiens_hsa041500.07165494
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06062552
156Thyroid cancer_Homo sapiens_hsa052160.05974495
157Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05825277
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.04928772
159PPAR signaling pathway_Homo sapiens_hsa033200.04897375
160Notch signaling pathway_Homo sapiens_hsa043300.04604760
161Fatty acid metabolism_Homo sapiens_hsa012120.03386206
162Amphetamine addiction_Homo sapiens_hsa050310.02760494

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