ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptonemal complex organization (GO:0070193)	9.73126688
2	chromosome organization involved in meiosis (GO:0070192)	9.58033209
3	synapsis (GO:0007129)	9.13216031
4	meiosis I (GO:0007127)	8.88407743
5	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.38145601
6	male meiosis (GO:0007140)	7.96024799
7	DNA methylation involved in gamete generation (GO:0043046)	7.67630784
8	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.34964596
9	regulation of histone H3-K9 methylation (GO:0051570)	7.24873026
10	meiotic nuclear division (GO:0007126)	7.14377978
11	positive regulation of meiosis (GO:0045836)	6.77049585
12	DNA synthesis involved in DNA repair (GO:0000731)	6.61878885
13	positive regulation of meiotic cell cycle (GO:0051446)	6.37639514
14	regulation of acrosome reaction (GO:0060046)	6.28274485
15	regulation of meiosis I (GO:0060631)	6.25070499
16	meiotic cell cycle process (GO:1903046)	6.15296812
17	multicellular organism reproduction (GO:0032504)	5.98346838
18	histone H3-K36 demethylation (GO:0070544)	5.67185704
19	meiotic cell cycle (GO:0051321)	5.41303419
20	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.20099231
21	oocyte development (GO:0048599)	5.16464683
22	histone lysine demethylation (GO:0070076)	5.09627718
23	sister chromatid cohesion (GO:0007062)	5.01286909
24	histone demethylation (GO:0016577)	4.86234028
25	gene silencing by RNA (GO:0031047)	4.86132354
26	cell wall macromolecule metabolic process (GO:0044036)	4.67312828
27	regulation of female receptivity (GO:0045924)	4.57513868
28	regulation of meiotic cell cycle (GO:0051445)	4.57453124
29	reciprocal meiotic recombination (GO:0007131)	4.54685199
30	reciprocal DNA recombination (GO:0035825)	4.54685199
31	positive regulation of histone H3-K4 methylation (GO:0051571)	4.46006821
32	regulation of meiosis (GO:0040020)	4.40701041
33	protein demethylation (GO:0006482)	4.39604689
34	protein dealkylation (GO:0008214)	4.39604689
35	regulation of female gonad development (GO:2000194)	4.25675443
36	regulation of uterine smooth muscle contraction (GO:0070472)	4.13130870
37	fertilization (GO:0009566)	4.10700515
38	meiotic chromosome segregation (GO:0045132)	4.08413690
39	reproduction (GO:0000003)	3.88970985
40	DNA alkylation (GO:0006305)	3.88910094
41	DNA methylation (GO:0006306)	3.88910094
42	binding of sperm to zona pellucida (GO:0007339)	3.87840024
43	female mating behavior (GO:0060180)	3.83755458
44	positive regulation of chemokine secretion (GO:0090197)	3.80196217
45	regulation of exit from mitosis (GO:0007096)	3.76946267
46	gonadal mesoderm development (GO:0007506)	3.75220993
47	glycine transport (GO:0015816)	3.74942758
48	sperm-egg recognition (GO:0035036)	3.69754803
49	single fertilization (GO:0007338)	3.69121447
50	positive regulation of histone methylation (GO:0031062)	3.67573991
51	N-terminal protein amino acid acetylation (GO:0006474)	3.66662819
52	female gamete generation (GO:0007292)	3.60872853
53	sex differentiation (GO:0007548)	3.53369093
54	glucosamine-containing compound catabolic process (GO:1901072)	3.50456065
55	resolution of meiotic recombination intermediates (GO:0000712)	3.50444667
56	gene silencing (GO:0016458)	3.50266320
57	DNA replication-dependent nucleosome organization (GO:0034723)	3.44726919
58	DNA replication-dependent nucleosome assembly (GO:0006335)	3.44726919
59	protein kinase C signaling (GO:0070528)	3.44669846
60	regulation of DNA endoreduplication (GO:0032875)	3.41965959
61	regulation of DNA methylation (GO:0044030)	3.36366985
62	regulation of chemokine secretion (GO:0090196)	3.35431692
63	mitotic chromosome condensation (GO:0007076)	3.35020860
64	cilium or flagellum-dependent cell motility (GO:0001539)	3.33464649
65	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.33178577
66	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.32937839
67	regulation of RIG-I signaling pathway (GO:0039535)	3.28999903
68	phosphorelay signal transduction system (GO:0000160)	3.28924295
69	attachment of spindle microtubules to kinetochore (GO:0008608)	3.27734337
70	hyperosmotic salinity response (GO:0042538)	3.25723165
71	negative regulation of digestive system process (GO:0060457)	3.24697129
72	embryonic body morphogenesis (GO:0010172)	3.24234323
73	positive regulation of catecholamine secretion (GO:0033605)	3.21432495
74	aggressive behavior (GO:0002118)	3.16227929
75	negative regulation of reproductive process (GO:2000242)	3.16057394
76	negative regulation of gene silencing (GO:0060969)	3.11870930
77	proteasome assembly (GO:0043248)	3.09257946
78	translesion synthesis (GO:0019985)	3.06540602
79	interkinetic nuclear migration (GO:0022027)	3.06481856
80	centriole replication (GO:0007099)	3.04069934
81	negative regulation of histone methylation (GO:0031061)	3.03537369
82	production of molecular mediator involved in inflammatory response (GO:0002532)	3.03483323
83	cell-cell recognition (GO:0009988)	3.02437657
84	positive regulation of digestive system process (GO:0060456)	3.00839464
85	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.00575893
86	reproductive system development (GO:0061458)	2.99070417
87	positive regulation of prostaglandin secretion (GO:0032308)	2.93199783
88	epithelial cilium movement (GO:0003351)	2.90421618
89	spermatid development (GO:0007286)	2.90177017
90	regulation of histone methylation (GO:0031060)	2.82950848
91	microtubule severing (GO:0051013)	2.81056672
92	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.79821989
93	DNA methylation or demethylation (GO:0044728)	2.79629560
94	sperm capacitation (GO:0048240)	2.73665771
95	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	2.72593641
96	chromosome organization (GO:0051276)	2.71420793
97	histone H3-K9 demethylation (GO:0033169)	11.4125587
98	male meiosis I (GO:0007141)	10.9902129
99	synaptonemal complex assembly (GO:0007130)	10.2937718
100	piRNA metabolic process (GO:0034587)	10.2498284

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	8.05869753
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.43357829
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.38255347
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.83704237
5	E2F7_22180533_ChIP-Seq_HELA_Human	2.69951436
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.58948849
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58641144
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.22131033
9	VDR_22108803_ChIP-Seq_LS180_Human	2.21194727
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.20639007
11	EZH2_22144423_ChIP-Seq_EOC_Human	10.3821488
12	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.99661689
13	RNF2_27304074_Chip-Seq_NSC_Mouse	1.99109704
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.97911393
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96931479
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90519797
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.87186362
18	TCF4_23295773_ChIP-Seq_U87_Human	1.72255536
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.69978395
20	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.65151537
21	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.63126651
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.63126651
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.63126651
24	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.58933125
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58722747
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56565236
27	AR_25329375_ChIP-Seq_VCAP_Human	1.56537444
28	STAT3_23295773_ChIP-Seq_U87_Human	1.55010187
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52549518
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.44156576
31	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.43974299
32	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.41750409
33	RUNX2_22187159_ChIP-Seq_PCA_Human	1.40992747
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40753348
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39799517
36	NCOR_22424771_ChIP-Seq_293T_Human	1.38050077
37	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.37312101
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36765958
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36640273
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34174729
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32475508
42	GATA3_26560356_Chip-Seq_TH1_Human	1.32210148
43	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29058747
44	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25573413
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24539685
46	CBP_21632823_ChIP-Seq_H3396_Human	1.22506614
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.21333529
48	RXR_22108803_ChIP-Seq_LS180_Human	1.20324994
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.18556938
50	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.16486002
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.13337861
52	SMRT_27268052_Chip-Seq_Bcells_Human	1.11925434
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.11460666
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11157256
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10209809
56	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08592961
57	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06544965
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05082626
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04249178
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03179038
61	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02012392
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01917935
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.01917935
64	ER_23166858_ChIP-Seq_MCF-7_Human	1.01647994
65	RAC3_21632823_ChIP-Seq_H3396_Human	1.01459445
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.01289233
67	KLF4_19829295_ChIP-Seq_ESCs_Human	1.01096546
68	P300_19829295_ChIP-Seq_ESCs_Human	1.00857605
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00390070
70	ERA_21632823_ChIP-Seq_H3396_Human	1.00262309
71	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99528223
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97794924
73	AR_20517297_ChIP-Seq_VCAP_Human	0.97516509
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97287136
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97188472
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96274720
77	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.96048359
78	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91525417
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.91209896
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90603201
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89306444
82	OCT4_19829295_ChIP-Seq_ESCs_Human	0.88209375
83	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.87731976
84	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.87252502
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.87188025
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.86828142
87	OCT4_20526341_ChIP-Seq_ESCs_Human	0.83777008
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.83575899
89	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.82981329
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.82705089
91	TAF15_26573619_Chip-Seq_HEK293_Human	0.82231249
92	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.81890224
93	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.81329102
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.80361204
95	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.79944806
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.77815727
97	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.77636226
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77583766
99	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.77391177
100	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.77272940

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	6.19562576
2	MP0006292_abnormal_olfactory_placode	4.69971279
3	MP0009379_abnormal_foot_pigmentation	4.38293245
4	MP0000678_abnormal_parathyroid_gland	3.79005480
5	MP0002160_abnormal_reproductive_system	3.66474947
6	MP0002210_abnormal_sex_determination	3.61832529
7	MP0001929_abnormal_gametogenesis	3.54722209
8	MP0003693_abnormal_embryo_hatching	3.16146869
9	MP0008058_abnormal_DNA_repair	2.93804519
10	MP0000427_abnormal_hair_cycle	2.83113521
11	MP0003718_maternal_effect	2.83104265
12	MP0003698_abnormal_male_reproductive	2.53877397
13	MP0000653_abnormal_sex_gland	2.45916659
14	MP0001145_abnormal_male_reproductive	2.40989401
15	MP0003950_abnormal_plasma_membrane	2.36678061
16	MP0005410_abnormal_fertilization	2.23072546
17	MP0003699_abnormal_female_reproductive	2.22996894
18	MP0008057_abnormal_DNA_replication	2.19939635
19	MP0005389_reproductive_system_phenotype	2.17702920
20	MP0003646_muscle_fatigue	1.98726569
21	MP0003136_yellow_coat_color	1.93910997
22	MP0008789_abnormal_olfactory_epithelium	1.87849620
23	MP0003890_abnormal_embryonic-extraembry	1.86997945
24	MP0002161_abnormal_fertility/fecundity	1.84790449
25	MP0005646_abnormal_pituitary_gland	1.83951073
26	MP0003283_abnormal_digestive_organ	1.80820123
27	MP0002638_abnormal_pupillary_reflex	1.78925574
28	MP0001664_abnormal_digestion	1.72914106
29	MP0001502_abnormal_circadian_rhythm	1.71303434
30	MP0001119_abnormal_female_reproductive	1.70789391
31	MP0003119_abnormal_digestive_system	1.69191800
32	MP0003879_abnormal_hair_cell	1.60059873
33	MP0005394_taste/olfaction_phenotype	1.59922169
34	MP0005499_abnormal_olfactory_system	1.59922169
35	MP0010094_abnormal_chromosome_stability	1.57605414
36	MP0008995_early_reproductive_senescence	1.55574754
37	MP0001764_abnormal_homeostasis	1.48307185
38	MP0004043_abnormal_pH_regulation	1.43895258
39	MP0003111_abnormal_nucleus_morphology	1.39421281
40	MP0009840_abnormal_foam_cell	1.38950955
41	MP0003077_abnormal_cell_cycle	1.38133497
42	MP0006276_abnormal_autonomic_nervous	1.34851343
43	MP0005551_abnormal_eye_electrophysiolog	1.32996638
44	MP0003936_abnormal_reproductive_system	1.29399442
45	MP0004142_abnormal_muscle_tone	1.29372770
46	MP0005409_darkened_coat_color	1.28509950
47	MP0000372_irregular_coat_pigmentation	1.28050023
48	MP0000015_abnormal_ear_pigmentation	1.27725814
49	MP0005360_urolithiasis	1.21982217
50	MP0000049_abnormal_middle_ear	1.18813443
51	MP0000631_abnormal_neuroendocrine_gland	1.16831028
52	MP0001666_abnormal_nutrient_absorption	1.13571643
53	MP0010307_abnormal_tumor_latency	1.13352090
54	MP0010030_abnormal_orbit_morphology	1.12925966
55	MP0005174_abnormal_tail_pigmentation	1.09494873
56	MP0000569_abnormal_digit_pigmentation	1.09302071
57	MP0002095_abnormal_skin_pigmentation	1.06384170
58	MP0003866_abnormal_defecation	1.03419625
59	MP0005647_abnormal_sex_gland	1.01525622
60	MP0000470_abnormal_stomach_morphology	1.01508049
61	MP0001730_embryonic_growth_arrest	0.94918575
62	MP0001986_abnormal_taste_sensitivity	0.84109487
63	MP0003786_premature_aging	0.80949032
64	MP0000383_abnormal_hair_follicle	0.80041246
65	MP0005253_abnormal_eye_physiology	0.78711608
66	MP0002249_abnormal_larynx_morphology	0.78704885
67	MP0002234_abnormal_pharynx_morphology	0.76514465
68	MP0005395_other_phenotype	0.74564635
69	MP0002138_abnormal_hepatobiliary_system	0.73357296
70	MP0002272_abnormal_nervous_system	0.72200943
71	MP0002277_abnormal_respiratory_mucosa	0.72009390
72	MP0002127_abnormal_cardiovascular_syste	0.71523484
73	MP0003959_abnormal_lean_body	0.70731299
74	MP0000350_abnormal_cell_proliferation	0.68591031
75	MP0001324_abnormal_eye_pigmentation	0.67916702
76	MP0003121_genomic_imprinting	0.67284794
77	MP0005645_abnormal_hypothalamus_physiol	0.65622257
78	MP0000647_abnormal_sebaceous_gland	0.65019066
79	MP0002084_abnormal_developmental_patter	0.61483550
80	MP0003938_abnormal_ear_development	0.61130594
81	MP0003937_abnormal_limbs/digits/tail_de	0.60059062
82	MP0010678_abnormal_skin_adnexa	0.59167038
83	MP0004019_abnormal_vitamin_homeostasis	0.58507369
84	MP0003183_abnormal_peptide_metabolism	0.56195986
85	MP0003868_abnormal_feces_composition	0.55899646
86	MP0005220_abnormal_exocrine_pancreas	0.55756486
87	MP0005076_abnormal_cell_differentiation	0.52694591
88	MP0001963_abnormal_hearing_physiology	0.52091567
89	MP0000566_synostosis	0.51579168
90	MP0002139_abnormal_hepatobiliary_system	0.51314630
91	MP0002067_abnormal_sensory_capabilities	0.49610246
92	MP0003943_abnormal_hepatobiliary_system	0.48555968
93	MP0002751_abnormal_autonomic_nervous	0.47897476
94	MP0002163_abnormal_gland_morphology	0.47576914
95	MP0002229_neurodegeneration	0.47108123
96	MP0002184_abnormal_innervation	0.46472344
97	MP0002233_abnormal_nose_morphology	0.46411259
98	MP0002085_abnormal_embryonic_tissue	0.45812359
99	MP0001765_abnormal_ion_homeostasis	0.44262161
100	MP0003935_abnormal_craniofacial_develop	0.43945295

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	4.67977724
2	Abnormality of abdominal situs (HP:0011620)	4.29095622
3	Abdominal situs inversus (HP:0003363)	4.29095622
4	Male infertility (HP:0003251)	4.28937571
5	Oligodactyly (hands) (HP:0001180)	4.08707566
6	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.04918759
7	Azoospermia (HP:0000027)	4.01309164
8	Median cleft lip (HP:0000161)	3.93708246
9	Impulsivity (HP:0100710)	3.91444366
10	Facial hemangioma (HP:0000329)	3.52944014
11	Lip pit (HP:0100267)	3.42383786
12	Attenuation of retinal blood vessels (HP:0007843)	3.37667092
13	Congenital sensorineural hearing impairment (HP:0008527)	3.30679266
14	Ectopic kidney (HP:0000086)	3.29869573
15	Abnormality of DNA repair (HP:0003254)	3.28631480
16	Spontaneous abortion (HP:0005268)	3.24957615
17	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.10420380
18	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.10420380
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.09724749
20	Hyperphosphatemia (HP:0002905)	3.05701403
21	Horizontal nystagmus (HP:0000666)	3.02618251
22	Anhidrosis (HP:0000970)	2.99336408
23	Tubulointerstitial nephritis (HP:0001970)	2.92068581
24	Gonadotropin excess (HP:0000837)	2.92047107
25	Abnormal ciliary motility (HP:0012262)	2.90327615
26	Shoulder girdle muscle weakness (HP:0003547)	2.88222796
27	Chromsome breakage (HP:0040012)	2.87962606
28	Osteomalacia (HP:0002749)	2.82765737
29	Supernumerary spleens (HP:0009799)	2.79742657
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.79412926
31	Abnormal spermatogenesis (HP:0008669)	2.72433571
32	Abnormality of the dental pulp (HP:0006479)	2.72049224
33	Short tibia (HP:0005736)	2.67811714
34	Oligodactyly (HP:0012165)	2.67711605
35	Hypophosphatemic rickets (HP:0004912)	2.61989422
36	Infertility (HP:0000789)	2.58496213
37	Anterior segment dysgenesis (HP:0007700)	2.58119819
38	Poikiloderma (HP:0001029)	2.57119969
39	Maternal diabetes (HP:0009800)	2.51617100
40	Hypoplastic iliac wings (HP:0002866)	2.38402397
41	Abnormal respiratory motile cilium physiology (HP:0012261)	2.35453987
42	Microglossia (HP:0000171)	2.35197523
43	Abnormality of the corticospinal tract (HP:0002492)	2.34037744
44	Impaired vibration sensation in the lower limbs (HP:0002166)	2.31647850
45	Decreased circulating renin level (HP:0003351)	2.31150600
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29872284
47	Abnormal number of incisors (HP:0011064)	2.28140619
48	Preaxial hand polydactyly (HP:0001177)	2.27498978
49	Small intestinal stenosis (HP:0012848)	2.24088448
50	Duodenal stenosis (HP:0100867)	2.24088448
51	Pili torti (HP:0003777)	2.22225223
52	Facial cleft (HP:0002006)	2.21944350
53	Entropion (HP:0000621)	2.17384779
54	Hyperkalemia (HP:0002153)	2.15632880
55	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.13510226
56	Microretrognathia (HP:0000308)	2.11213167
57	Dry hair (HP:0011359)	2.11188912
58	Bundle branch block (HP:0011710)	2.09398902
59	Neurofibrillary tangles (HP:0002185)	2.07589882
60	Rhinitis (HP:0012384)	2.07323229
61	Fair hair (HP:0002286)	2.05982879
62	Nephroblastoma (Wilms tumor) (HP:0002667)	2.01914082
63	Absent/shortened dynein arms (HP:0200106)	2.01213020
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01213020
65	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01102578
66	Absent thumb (HP:0009777)	1.99520887
67	Hyperactive renin-angiotensin system (HP:0000841)	1.98164079
68	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.97964638
69	Abnormality of the nasal septum (HP:0000419)	1.97376776
70	Loss of speech (HP:0002371)	1.94987417
71	11 pairs of ribs (HP:0000878)	1.93146121
72	Truncal obesity (HP:0001956)	1.93045801
73	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.92249020
74	Hypoplasia of the fovea (HP:0007750)	1.92249020
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91329604
76	Tetany (HP:0001281)	1.90958051
77	Papillary thyroid carcinoma (HP:0002895)	1.90034375
78	Oligodontia (HP:0000677)	1.89798288
79	Abnormality of chromosome stability (HP:0003220)	1.88727193
80	Pancreatic fibrosis (HP:0100732)	1.87398518
81	Urinary bladder sphincter dysfunction (HP:0002839)	1.87203970
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87009107
83	Embryonal renal neoplasm (HP:0011794)	1.85393771
84	Abnormality of dentin (HP:0010299)	1.83914628
85	Abnormal pancreas size (HP:0012094)	1.83388461
86	Dysdiadochokinesis (HP:0002075)	1.82599793
87	Abnormality of the renal collecting system (HP:0004742)	1.81908732
88	Rimmed vacuoles (HP:0003805)	1.79465600
89	Capillary hemangiomas (HP:0005306)	1.79430470
90	Abnormality of the preputium (HP:0100587)	1.78398239
91	Gaze-evoked nystagmus (HP:0000640)	1.78097546
92	Wrist flexion contracture (HP:0001239)	1.76814998
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.76400597
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.76400597
95	Abnormality of the duodenum (HP:0002246)	1.75623965
96	Abnormality of midbrain morphology (HP:0002418)	1.75136122
97	Molar tooth sign on MRI (HP:0002419)	1.75136122
98	Genetic anticipation (HP:0003743)	1.74951845
99	Meckel diverticulum (HP:0002245)	1.74488016
100	Urinary urgency (HP:0000012)	1.73660013

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	6.23909339
2	PNCK	4.95934679
3	MET	4.29913510
4	STK16	2.95015938
5	MAP3K9	2.70216528
6	CDK12	2.48770060
7	CSF1R	2.28458457
8	TAOK3	2.16387116
9	AURKA	2.07421453
10	NEK6	2.00557870
11	MELK	2.00443664
12	TTK	1.86945051
13	PTK2B	1.82027313
14	CAMK1G	1.80157887
15	PLK4	1.78483100
16	OXSR1	1.73663244
17	TESK2	1.71646995
18	ARAF	1.65240692
19	TNIK	1.64905429
20	WNK1	1.64229513
21	ZAK	1.54698401
22	FGR	1.52420451
23	SIK2	1.41847897
24	PLK1	1.39587051
25	MST1R	1.38959590
26	WNK4	1.38213429
27	PASK	1.33323076
28	BMX	1.32019468
29	TLK1	1.31268120
30	RET	1.29917033
31	STK24	1.27251885
32	PRKCI	1.26402449
33	BMPR1B	1.22857425
34	MAP3K5	1.21089383
35	MARK3	1.19491682
36	VRK1	1.18913234
37	CHEK2	1.16354600
38	MAPKAPK3	1.15520192
39	NEK2	1.08664223
40	CDK7	1.08205841
41	PLK2	1.07634010
42	NUAK1	0.94668726
43	TRIM28	0.94509621
44	ACVR1B	0.93820165
45	LIMK1	0.92889186
46	TAOK2	0.92707202
47	ATR	0.92053723
48	MAP3K13	0.84408111
49	PDK1	0.84376907
50	ADRBK1	0.84283025
51	CHEK1	0.83036311
52	BRAF	0.81845048
53	PIK3CG	0.81591011
54	BUB1	0.81091213
55	TYRO3	0.80766017
56	STK39	0.77505623
57	SRPK1	0.75209788
58	PTK2	0.74790217
59	NLK	0.74336899
60	MAP3K12	0.72977281
61	NEK9	0.72958883
62	MAPK13	0.69733458
63	NTRK3	0.68222970
64	PRPF4B	0.66124768
65	PDK2	0.65421403
66	EPHA4	0.59924349
67	MAPK11	0.57478086
68	NEK1	0.56975346
69	NME1	0.55114715
70	CSNK1E	0.53818206
71	RAF1	0.53321769
72	MAP4K1	0.52775424
73	TNK2	0.51271437
74	CAMK1	0.51049441
75	STK38L	0.50884186
76	RPS6KB1	0.50301690
77	AURKB	0.49059240
78	MOS	0.48651794
79	CDK2	0.48630076
80	ATM	0.48611329
81	MAP3K3	0.46756332
82	PIM1	0.45937665
83	PDPK1	0.44902140
84	PBK	0.43875233
85	CDC7	0.43727788
86	CDK8	0.43247006
87	PDGFRB	0.41874763
88	TEC	0.41496899
89	LATS2	0.39794536
90	PKN1	0.37102983
91	EGFR	0.36458451
92	STK3	0.35931550
93	MARK2	0.35012611
94	CDK11A	0.33632335
95	GRK1	0.31723449
96	CDK1	0.30578981
97	IGF1R	0.30057381
98	MAP2K3	0.29743652
99	PRKG1	0.29514409
100	CDK9	0.29405534

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.11572664
2	Phototransduction_Homo sapiens_hsa04744	3.72060601
3	Basal transcription factors_Homo sapiens_hsa03022	3.65826885
4	Mismatch repair_Homo sapiens_hsa03430	3.50124050
5	Homologous recombination_Homo sapiens_hsa03440	3.47596565
6	Oocyte meiosis_Homo sapiens_hsa04114	3.29782087
7	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	3.20595824
8	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.75978634
9	Cell cycle_Homo sapiens_hsa04110	2.72310879
10	DNA replication_Homo sapiens_hsa03030	2.35884727
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.28433033
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.23834340
13	RNA transport_Homo sapiens_hsa03013	2.22719871
14	Olfactory transduction_Homo sapiens_hsa04740	2.04130850
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97346176
16	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.95027020
17	mRNA surveillance pathway_Homo sapiens_hsa03015	1.92671996
18	Base excision repair_Homo sapiens_hsa03410	1.92175411
19	RNA degradation_Homo sapiens_hsa03018	1.87760101
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56294161
21	Taste transduction_Homo sapiens_hsa04742	1.49619744
22	RNA polymerase_Homo sapiens_hsa03020	1.45950629
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.42861606
24	Regulation of autophagy_Homo sapiens_hsa04140	1.29721210
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.29585511
26	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.28422306
27	p53 signaling pathway_Homo sapiens_hsa04115	1.23935425
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19934684
29	Bile secretion_Homo sapiens_hsa04976	1.16483489
30	Circadian rhythm_Homo sapiens_hsa04710	1.13388913
31	Retinol metabolism_Homo sapiens_hsa00830	1.12145435
32	Ribosome_Homo sapiens_hsa03010	1.11136711
33	ABC transporters_Homo sapiens_hsa02010	1.09552943
34	Purine metabolism_Homo sapiens_hsa00230	0.99157368
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94684208
36	Nicotine addiction_Homo sapiens_hsa05033	0.94575889
37	Morphine addiction_Homo sapiens_hsa05032	0.92099182
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91906329
39	Calcium signaling pathway_Homo sapiens_hsa04020	0.86886276
40	Caffeine metabolism_Homo sapiens_hsa00232	0.86161244
41	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.84097128
42	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81691650
43	Selenocompound metabolism_Homo sapiens_hsa00450	0.79407053
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77433590
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.73755409
46	Circadian entrainment_Homo sapiens_hsa04713	0.71734894
47	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.64358558
48	Insulin secretion_Homo sapiens_hsa04911	0.64335170
49	GABAergic synapse_Homo sapiens_hsa04727	0.63914341
50	Lysine degradation_Homo sapiens_hsa00310	0.63514535
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63132161
52	Serotonergic synapse_Homo sapiens_hsa04726	0.62112558
53	Herpes simplex infection_Homo sapiens_hsa05168	0.60803247
54	Cholinergic synapse_Homo sapiens_hsa04725	0.59055355
55	Small cell lung cancer_Homo sapiens_hsa05222	0.53460717
56	Arginine biosynthesis_Homo sapiens_hsa00220	0.51215421
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.49494609
58	Viral carcinogenesis_Homo sapiens_hsa05203	0.48608328
59	Alcoholism_Homo sapiens_hsa05034	0.47019263
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.46737652
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42319433
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41299658
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.41277296
64	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40308476
65	Glutamatergic synapse_Homo sapiens_hsa04724	0.39786286
66	HTLV-I infection_Homo sapiens_hsa05166	0.39378186
67	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.39091835
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.38456962
69	Gap junction_Homo sapiens_hsa04540	0.38181511
70	Huntingtons disease_Homo sapiens_hsa05016	0.36151271
71	Cocaine addiction_Homo sapiens_hsa05030	0.35639046
72	Adherens junction_Homo sapiens_hsa04520	0.34309810
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.33951075
74	Sulfur metabolism_Homo sapiens_hsa00920	0.32664188
75	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.29777757
76	Salivary secretion_Homo sapiens_hsa04970	0.29692442
77	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29537657
78	MAPK signaling pathway_Homo sapiens_hsa04010	0.29483786
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.29063527
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28914198
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.28456025
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28010216
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26443242
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25321007
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.24876518
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.23630055
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.22713154
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.22310060
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.21876124
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.21693775
91	Ras signaling pathway_Homo sapiens_hsa04014	0.20592363
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20347905
93	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.20101169
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.19964931
95	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.19429322
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.19378392
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.18934220
98	Spliceosome_Homo sapiens_hsa03040	0.18453368
99	mTOR signaling pathway_Homo sapiens_hsa04150	0.17342038
100	Gastric acid secretion_Homo sapiens_hsa04971	0.17140716

PRR20C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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