PRR22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.94764724
2acrosome assembly (GO:0001675)9.90392109
3cell-cell recognition (GO:0009988)9.52374418
4spermatid development (GO:0007286)9.02045982
5multicellular organism reproduction (GO:0032504)8.78669156
6plasma membrane fusion (GO:0045026)8.46756736
7axonemal dynein complex assembly (GO:0070286)8.46317202
8motile cilium assembly (GO:0044458)8.26017250
9regulation of cilium movement (GO:0003352)8.12123252
10epithelial cilium movement (GO:0003351)8.02962791
11reproduction (GO:0000003)7.63659606
12cilium or flagellum-dependent cell motility (GO:0001539)7.60872030
13synaptonemal complex organization (GO:0070193)6.63702308
14negative regulation of inclusion body assembly (GO:0090084)6.61038158
15synaptonemal complex assembly (GO:0007130)6.53005858
16cilium movement (GO:0003341)6.28735261
17piRNA metabolic process (GO:0034587)6.28311271
18male meiosis (GO:0007140)6.22440071
19single fertilization (GO:0007338)6.17002565
20spermatogenesis (GO:0007283)6.14131141
21male gamete generation (GO:0048232)6.12357704
22organic cation transport (GO:0015695)5.93081675
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.91400792
24sperm capacitation (GO:0048240)5.87188358
25mannose metabolic process (GO:0006013)5.87168690
26microtubule depolymerization (GO:0007019)5.83609504
27chromosome condensation (GO:0030261)5.80229564
28DNA packaging (GO:0006323)5.63901941
29ribosomal small subunit biogenesis (GO:0042274)5.63576359
30gamete generation (GO:0007276)5.60533892
31regulation of inclusion body assembly (GO:0090083)5.56652835
32fertilization (GO:0009566)5.37808315
33germ cell development (GO:0007281)5.03268978
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.89965424
35calcium ion-dependent exocytosis (GO:0017156)4.89125023
36regulation of microtubule-based movement (GO:0060632)4.76208649
37regulation of chromatin binding (GO:0035561)4.75358594
38seminiferous tubule development (GO:0072520)4.70989550
39male meiosis I (GO:0007141)4.62329227
40chaperone-mediated protein complex assembly (GO:0051131)4.45037225
41glycerol ether metabolic process (GO:0006662)4.41645321
42multicellular organismal reproductive process (GO:0048609)4.39027624
43negative regulation of cell size (GO:0045792)4.37547179
44chromosome organization involved in meiosis (GO:0070192)4.31820714
45ventricular system development (GO:0021591)4.27382956
46cell recognition (GO:0008037)4.26825032
47ncRNA 3-end processing (GO:0043628)4.23033229
48negative regulation of erythrocyte differentiation (GO:0045647)4.22866311
49mitotic sister chromatid cohesion (GO:0007064)4.21409893
50ether metabolic process (GO:0018904)4.07887560
51meiotic nuclear division (GO:0007126)4.05125662
52GDP-mannose metabolic process (GO:0019673)4.04799705
53DNA methylation involved in gamete generation (GO:0043046)4.01029330
54meiosis I (GO:0007127)3.90728842
55left/right pattern formation (GO:0060972)3.81111451
56regulation of spindle checkpoint (GO:0090231)3.78276881
57microtubule severing (GO:0051013)3.70741614
58spermatid nucleus differentiation (GO:0007289)3.69711300
59NIK/NF-kappaB signaling (GO:0038061)3.69503274
60regulation of translational fidelity (GO:0006450)3.67110936
61single strand break repair (GO:0000012)3.62625826
62sexual reproduction (GO:0019953)3.61126183
63apoptotic process involved in morphogenesis (GO:0060561)3.60046100
64multicellular organismal development (GO:0007275)3.56535580
65regulation of mammary gland epithelial cell proliferation (GO:0033599)3.52027857
66nucleus organization (GO:0006997)3.48480362
67sequestering of actin monomers (GO:0042989)3.48115264
68folic acid metabolic process (GO:0046655)3.45612228
69meiotic cell cycle (GO:0051321)3.42340676
70protein refolding (GO:0042026)3.42051735
71formation of translation preinitiation complex (GO:0001731)3.41003420
72viral transcription (GO:0019083)3.40623620
73protein polyglutamylation (GO:0018095)3.37855526
74protein localization to chromosome, centromeric region (GO:0071459)3.34672753
75cellular protein complex localization (GO:0034629)3.34113875
76interferon-gamma secretion (GO:0072643)3.31639782
77mitotic chromosome condensation (GO:0007076)3.30738932
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28143002
79ribonucleoprotein complex biogenesis (GO:0022613)3.25198040
80RNA destabilization (GO:0050779)3.25180376
81RNA localization (GO:0006403)3.24073685
82DNA unwinding involved in DNA replication (GO:0006268)3.23989039
83ribosomal small subunit assembly (GO:0000028)3.13744050
84genitalia morphogenesis (GO:0035112)3.13582559
85chromatin silencing (GO:0006342)3.13066407
86polyamine biosynthetic process (GO:0006596)3.12195197
87proline biosynthetic process (GO:0006561)3.11157628
88protein-DNA complex disassembly (GO:0032986)3.07525167
89nucleosome disassembly (GO:0006337)3.07525167
90DNA replication checkpoint (GO:0000076)3.05545647
91translational termination (GO:0006415)3.04244347
92UV protection (GO:0009650)3.01354578
93spliceosomal tri-snRNP complex assembly (GO:0000244)3.00993568
94glycolytic process (GO:0006096)3.00129199
95peptidyl-arginine omega-N-methylation (GO:0035247)2.99207444
96regulation of histone H3-K9 methylation (GO:0051570)2.97303670
97negative regulation of RNA splicing (GO:0033119)2.95189750
98meiotic cell cycle process (GO:1903046)2.94931977
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94923996
100regulation of early endosome to late endosome transport (GO:2000641)2.92845380
101monoubiquitinated protein deubiquitination (GO:0035520)2.91097504
102gene silencing by RNA (GO:0031047)2.90366198
103response to peptidoglycan (GO:0032494)2.90339957
104protein complex localization (GO:0031503)2.89728071
105nuclear pore complex assembly (GO:0051292)2.88041539
106heterochromatin organization (GO:0070828)2.87978070
107maturation of SSU-rRNA (GO:0030490)2.86344941
108misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.84282752
109translational elongation (GO:0006414)2.81312058
110gene silencing (GO:0016458)2.79671648
111negative regulation of gene expression, epigenetic (GO:0045814)2.79216979
112ribosomal large subunit biogenesis (GO:0042273)2.79040385
113DNA replication initiation (GO:0006270)2.78607160
114histone arginine methylation (GO:0034969)2.77533123
115DNA conformation change (GO:0071103)2.75601904
116modulation by virus of host process (GO:0019054)2.75122768
117cellular response to ATP (GO:0071318)2.74834296
118nucleoside diphosphate phosphorylation (GO:0006165)2.73536883
119snRNA metabolic process (GO:0016073)2.72658960
120UTP biosynthetic process (GO:0006228)2.72311868
121rRNA transcription (GO:0009303)2.71789117
122DNA replication-dependent nucleosome assembly (GO:0006335)2.70365790
123DNA replication-dependent nucleosome organization (GO:0034723)2.70365790
1243-UTR-mediated mRNA stabilization (GO:0070935)2.69762545
125DNA deamination (GO:0045006)2.69502385
126ribosome biogenesis (GO:0042254)2.69027735
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68211838
128microtubule polymerization or depolymerization (GO:0031109)2.67601441
129amino-acid betaine transport (GO:0015838)2.67289139
130carnitine transport (GO:0015879)2.67289139
131GTP biosynthetic process (GO:0006183)2.67280470
132positive regulation of macrophage activation (GO:0043032)2.66678578
133translesion synthesis (GO:0019985)2.65544894
134pseudouridine synthesis (GO:0001522)2.65111337
135adenosine receptor signaling pathway (GO:0001973)2.64864414
136regulation of cilium assembly (GO:1902017)2.63540660
137viral mRNA export from host cell nucleus (GO:0046784)2.61941523
138tolerance induction (GO:0002507)2.59975862
139viral life cycle (GO:0019058)2.59794768
140histone exchange (GO:0043486)2.58707404
141modulation by symbiont of host cellular process (GO:0044068)2.58375230
142cellular hyperosmotic response (GO:0071474)2.57937582
143DNA topological change (GO:0006265)2.57910982
144carnitine transmembrane transport (GO:1902603)2.53869713
145DNA strand elongation involved in DNA replication (GO:0006271)2.52853895
146negative regulation of viral release from host cell (GO:1902187)2.51804250
147CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.51626468
148DNA strand elongation (GO:0022616)2.50206208
149negative regulation of mRNA processing (GO:0050686)2.48968648
150negative regulation of mRNA metabolic process (GO:1903312)2.47608290
151transcription from mitochondrial promoter (GO:0006390)2.47188201
152regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45746161
153rRNA processing (GO:0006364)2.45137745
154negative regulation of B cell apoptotic process (GO:0002903)2.44725025
155negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43846553
156pyrimidine-containing compound salvage (GO:0008655)2.43426802
157pyrimidine nucleoside salvage (GO:0043097)2.43426802
158positive regulation of gamma-delta T cell activation (GO:0046645)2.41932575
159nucleotide salvage (GO:0043173)2.41743323
160positive thymic T cell selection (GO:0045059)2.41698299
161tRNA modification (GO:0006400)2.41457818
162cellular protein complex disassembly (GO:0043624)2.40815823
163T cell lineage commitment (GO:0002360)2.40403406
164folic acid transport (GO:0015884)2.38927010
165rRNA methylation (GO:0031167)2.38527360
166mitotic G1/S transition checkpoint (GO:0044819)2.38140936
167positive regulation of megakaryocyte differentiation (GO:0045654)2.37817950
168regulation of chemokine biosynthetic process (GO:0045073)2.37475669
169DNA duplex unwinding (GO:0032508)2.36122992
170regulation of necrotic cell death (GO:0010939)2.36064399
171rRNA modification (GO:0000154)2.35973064
172intracellular estrogen receptor signaling pathway (GO:0030520)2.35869632
173kinetochore assembly (GO:0051382)2.35551564
174regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35447828
175regulation of histone H3-K27 methylation (GO:0061085)2.32343423
176thymic T cell selection (GO:0045061)2.31969241
177negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.31702872
178lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30889986
179pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.30350926
180rRNA metabolic process (GO:0016072)2.28861707
181DNA strand renaturation (GO:0000733)2.28139545
182receptor recycling (GO:0001881)2.27990880
183cellular response to virus (GO:0098586)2.27335156
184histone phosphorylation (GO:0016572)2.26506621
185protein complex disassembly (GO:0043241)2.26500240
186negative regulation of necrotic cell death (GO:0060547)2.26458910
187snRNA processing (GO:0016180)2.26258446
188translational initiation (GO:0006413)2.26080127
189myeloid dendritic cell differentiation (GO:0043011)2.26044221
190cellular response to arsenic-containing substance (GO:0071243)2.25432100
191activation of Rac GTPase activity (GO:0032863)2.25402925
192pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.24739138
193erythrocyte maturation (GO:0043249)2.24694345
194sperm motility (GO:0030317)12.3505046
195fusion of sperm to egg plasma membrane (GO:0007342)11.2560112
196acrosome reaction (GO:0007340)11.1350082
197cell wall macromolecule metabolic process (GO:0044036)10.7207567
198cell wall macromolecule catabolic process (GO:0016998)10.7207567
199sperm-egg recognition (GO:0035036)10.5973771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.34840271
2VDR_21846776_ChIP-Seq_THP-1_Human3.41254988
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.11323561
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07892424
5CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.81294083
6LXR_22292898_ChIP-Seq_THP-1_Human2.50679516
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37314874
8EZH2_22144423_ChIP-Seq_EOC_Human2.36469488
9E2F7_22180533_ChIP-Seq_HELA_Human2.35715899
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35223924
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18505002
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14013599
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10570950
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10450482
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.03421766
16XRN2_22483619_ChIP-Seq_HELA_Human1.93745963
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.87722536
18FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87539003
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.85422054
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84597235
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84251080
22VDR_24763502_ChIP-Seq_THP-1_Human1.76689238
23RACK7_27058665_Chip-Seq_MCF-7_Human1.76384013
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73834320
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73629262
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70933404
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70713284
28ZNF263_19887448_ChIP-Seq_K562_Human1.69681315
29FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.67599614
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65793849
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64722848
32KDM2B_26808549_Chip-Seq_DND41_Human1.61504152
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.61407496
34MAF_26560356_Chip-Seq_TH1_Human1.58790108
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.56909525
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55791895
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.53112109
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52169489
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51801386
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.46834401
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.46456415
42* SA1_27219007_Chip-Seq_ERYTHROID_Human1.45891105
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.45689550
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43594694
45ZNF274_21170338_ChIP-Seq_K562_Hela1.43444155
46SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43344456
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42912566
48SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42271984
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42060472
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41030970
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40750355
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40638841
53TCF7_22412390_ChIP-Seq_EML_Mouse1.39327772
54NCOR1_26117541_ChIP-Seq_K562_Human1.38111775
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35750000
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35658576
57DCP1A_22483619_ChIP-Seq_HELA_Human1.35452754
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.35166187
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34651614
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33604921
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33206922
62UTX_26944678_Chip-Seq_JUKART_Human1.33137195
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32870888
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32513370
65P53_21459846_ChIP-Seq_SAOS-2_Human1.30697152
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29983945
67PHF8_20622854_ChIP-Seq_HELA_Human1.29873082
68BCOR_27268052_Chip-Seq_Bcells_Human1.29692714
69GABP_19822575_ChIP-Seq_HepG2_Human1.28901049
70STAT1_17558387_ChIP-Seq_HELA_Human1.28047866
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27972626
72BCL6_27268052_Chip-Seq_Bcells_Human1.27157885
73CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26991562
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26507759
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25456581
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24798705
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24245102
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24112636
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23499916
80CTCF_26484167_Chip-Seq_Bcells_Mouse1.23193701
81CREB1_26743006_Chip-Seq_LNCaP_Human1.22802316
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22746753
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.22141500
84CIITA_25753668_ChIP-Seq_RAJI_Human1.21906897
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.21898653
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21160799
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21079105
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20889117
89BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20525088
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20194341
91MYC_22102868_ChIP-Seq_BL_Human1.20057460
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19957370
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19461469
94SPI1_26923725_Chip-Seq_HPCs_Mouse1.19095124
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18778998
96RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17825318
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17697876
98CTCF_21964334_Chip-Seq_Bcells_Human1.17311445
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14754335
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13947749
101VDR_22108803_ChIP-Seq_LS180_Human1.13819498
102GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.13231698
103LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10766179
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10068469
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09985072
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09869678
107* CTCF_20526341_ChIP-Seq_ESCs_Human1.09440958
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08699430
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08254298
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08138037
111FLI1_21867929_ChIP-Seq_CD8_Mouse1.07596522
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07218878
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.06967633
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06610268
115KDM2B_26808549_Chip-Seq_K562_Human1.06040714
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06022039
117TP63_17297297_ChIP-ChIP_HaCaT_Human1.05539529
118ATF3_27146783_Chip-Seq_COLON_Human1.05071578
119SCL_19346495_ChIP-Seq_HPC-7_Human1.05003362
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.04940871
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03965142
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03121822
123MYB_26560356_Chip-Seq_TH2_Human1.03066566
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01803755
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00419564
126SPI1_20517297_ChIP-Seq_HL60_Human1.00062715
127MYC_18555785_ChIP-Seq_MESCs_Mouse0.99908609
128GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99596185
129MYB_26560356_Chip-Seq_TH1_Human0.99344545
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99303946
131ETS1_21867929_ChIP-Seq_TH2_Mouse0.99085349
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98798355
133P300_27268052_Chip-Seq_Bcells_Human0.98795237
134P68_20966046_ChIP-Seq_HELA_Human0.98642059
135RUNX1_22412390_ChIP-Seq_EML_Mouse0.98563204
136EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98459500
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98087952
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97519051
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97439535
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96272849
141SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95354209
142MYC_27129775_Chip-Seq_CORNEA_Mouse0.95282048
143JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95260581
144GATA3_21867929_ChIP-Seq_TH1_Mouse0.95199092
145E2F1_20622854_ChIP-Seq_HELA_Human0.93697819
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93380899
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93206278
148SMC4_20622854_ChIP-Seq_HELA_Human0.91820941
149ERG_20517297_ChIP-Seq_VCAP_Human0.91686499
150SOX2_21211035_ChIP-Seq_LN229_Human0.91470640
151E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91453296
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91255738
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90970897
154MAF_26560356_Chip-Seq_TH2_Human0.90928157
155TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90543243
156LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90432389
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89308288
158MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89290593
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.88043726
160SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86951243
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86642590
162CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86407829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.37652654
2MP0001929_abnormal_gametogenesis5.06058820
3MP0008877_abnormal_DNA_methylation3.88294322
4MP0005058_abnormal_lysosome_morphology3.22930333
5MP0000678_abnormal_parathyroid_gland3.17538366
6MP0002210_abnormal_sex_determination3.09355992
7MP0002161_abnormal_fertility/fecundity2.96324225
8MP0005670_abnormal_white_adipose2.83734405
9MP0009333_abnormal_splenocyte_physiolog2.74982304
10MP0001145_abnormal_male_reproductive2.69065031
11MP0005076_abnormal_cell_differentiation2.62019526
12MP0009840_abnormal_foam_cell2.45577852
13MP0000013_abnormal_adipose_tissue2.34294372
14MP0003436_decreased_susceptibility_to2.33978183
15MP0000653_abnormal_sex_gland2.28651342
16MP0003172_abnormal_lysosome_physiology2.21408434
17MP0004185_abnormal_adipocyte_glucose2.00711023
18MP0005410_abnormal_fertilization14.8001021
19MP0002877_abnormal_melanocyte_morpholog1.94718848
20MP0003111_abnormal_nucleus_morphology1.91616347
21MP0001849_ear_inflammation1.86016955
22MP0010094_abnormal_chromosome_stability1.85906216
23MP0000003_abnormal_adipose_tissue1.81616537
24MP0003693_abnormal_embryo_hatching1.76237645
25MP0003453_abnormal_keratinocyte_physiol1.69964324
26MP0008058_abnormal_DNA_repair1.67849997
27MP0002160_abnormal_reproductive_system1.61596456
28MP0005397_hematopoietic_system_phenotyp1.58019530
29MP0001545_abnormal_hematopoietic_system1.58019530
30MP0006082_CNS_inflammation1.53829801
31MP0005375_adipose_tissue_phenotype1.52969884
32MP0008260_abnormal_autophagy1.51231654
33MP0003646_muscle_fatigue1.47315844
34MP0002653_abnormal_ependyma_morphology1.44705837
35MP0005387_immune_system_phenotype1.41582831
36MP0001790_abnormal_immune_system1.41582831
37MP0003077_abnormal_cell_cycle1.40262319
38MP0004947_skin_inflammation1.40121522
39MP0008057_abnormal_DNA_replication1.39451213
40MP0009384_cardiac_valve_regurgitation1.38207937
41MP0005000_abnormal_immune_tolerance1.35989377
42MP0003705_abnormal_hypodermis_morpholog1.35874426
43MP0003806_abnormal_nucleotide_metabolis1.29474888
44MP0002249_abnormal_larynx_morphology1.28757848
45MP0002396_abnormal_hematopoietic_system1.27802441
46MP0009379_abnormal_foot_pigmentation1.27758657
47MP0009278_abnormal_bone_marrow1.25011177
48MP0003191_abnormal_cellular_cholesterol1.24939738
49MP0004957_abnormal_blastocyst_morpholog1.24354602
50MP0004808_abnormal_hematopoietic_stem1.21222937
51MP0001730_embryonic_growth_arrest1.20366436
52MP0004381_abnormal_hair_follicle1.19647585
53MP0008007_abnormal_cellular_replicative1.16835342
54MP0000681_abnormal_thyroid_gland1.14534552
55MP0002419_abnormal_innate_immunity1.13906111
56MP0002148_abnormal_hypersensitivity_rea1.08471060
57MP0000015_abnormal_ear_pigmentation1.02203327
58MP0005501_abnormal_skin_physiology1.01559819
59MP0009931_abnormal_skin_appearance1.01249706
60MP0000733_abnormal_muscle_development1.01136380
61MP0003878_abnormal_ear_physiology1.00536156
62MP0005377_hearing/vestibular/ear_phenot1.00536156
63MP0004233_abnormal_muscle_weight1.00324452
64MP0002796_impaired_skin_barrier0.99353671
65MP0004858_abnormal_nervous_system0.95679676
66MP0010155_abnormal_intestine_physiology0.94790887
67MP0004510_myositis0.91242772
68MP0002398_abnormal_bone_marrow0.90307433
69MP0003300_gastrointestinal_ulcer0.90272183
70MP0005671_abnormal_response_to0.89996863
71MP0001765_abnormal_ion_homeostasis0.89380009
72MP0003115_abnormal_respiratory_system0.86883592
73MP0000358_abnormal_cell_content/0.82744990
74MP0008469_abnormal_protein_level0.82199308
75MP0004782_abnormal_surfactant_physiolog0.79642978
76MP0005389_reproductive_system_phenotype0.78318924
77MP0000703_abnormal_thymus_morphology0.77545038
78MP0001845_abnormal_inflammatory_respons0.77025135
79MP0000313_abnormal_cell_death0.76818119
80MP0003763_abnormal_thymus_physiology0.75556786
81MP0002098_abnormal_vibrissa_morphology0.75480652
82MP0001661_extended_life_span0.73825550
83MP0005623_abnormal_meninges_morphology0.72488150
84MP0006036_abnormal_mitochondrial_physio0.72246546
85MP0001663_abnormal_digestive_system0.72127221
86MP0002080_prenatal_lethality0.71761610
87MP0000689_abnormal_spleen_morphology0.71579850
88MP0003448_altered_tumor_morphology0.71390860
89MP0003786_premature_aging0.70767926
90MP0005310_abnormal_salivary_gland0.70266395
91MP0001672_abnormal_embryogenesis/_devel0.70040571
92MP0005380_embryogenesis_phenotype0.70040571
93MP0005451_abnormal_body_composition0.69708916
94MP0008995_early_reproductive_senescence0.69288891
95MP0009785_altered_susceptibility_to0.69083061
96MP0002998_abnormal_bone_remodeling0.68279575
97MP0001697_abnormal_embryo_size0.68260883
98MP0008961_abnormal_basal_metabolism0.67048160
99MP0001216_abnormal_epidermal_layer0.66671004
100MP0010307_abnormal_tumor_latency0.66235438
101MP0002139_abnormal_hepatobiliary_system0.66159143
102MP0001533_abnormal_skeleton_physiology0.65282345
103MP0005636_abnormal_mineral_homeostasis0.65136627
104MP0002928_abnormal_bile_duct0.64344298
105MP0002722_abnormal_immune_system0.63574594
106MP0002405_respiratory_system_inflammati0.63364254
107MP0001764_abnormal_homeostasis0.63044272
108MP0003984_embryonic_growth_retardation0.62934975
109MP0002269_muscular_atrophy0.61763233
110MP0000350_abnormal_cell_proliferation0.61621254
111MP0002429_abnormal_blood_cell0.60934564
112MP0002088_abnormal_embryonic_growth/wei0.60317706
113MP0001293_anophthalmia0.59748180
114MP0002234_abnormal_pharynx_morphology0.59307593
115MP0009672_abnormal_birth_weight0.57434137
116MP0000716_abnormal_immune_system0.56917286
117MP0008932_abnormal_embryonic_tissue0.56530886
118MP0002723_abnormal_immune_serum0.55724073
119MP0003943_abnormal_hepatobiliary_system0.55155261
120MP0002084_abnormal_developmental_patter0.53800229
121MP0001800_abnormal_humoral_immune0.53338263
122MP0000858_altered_metastatic_potential0.51567047
123MP0002282_abnormal_trachea_morphology0.50475438
124MP0001873_stomach_inflammation0.50387634
125MP0002019_abnormal_tumor_incidence0.49817387
126MP0003866_abnormal_defecation0.49620181
127MP0003699_abnormal_female_reproductive0.49371643
128MP0002420_abnormal_adaptive_immunity0.49140873
129MP0003303_peritoneal_inflammation0.48533829
130MP0000685_abnormal_immune_system0.48382551
131MP0001835_abnormal_antigen_presentation0.47516918
132MP0005666_abnormal_adipose_tissue0.46530321
133MP0001819_abnormal_immune_cell0.46140690
134MP0004133_heterotaxia0.45738313
135MP0002132_abnormal_respiratory_system0.43772579
136MP0005647_abnormal_sex_gland0.43596309
137MP0004036_abnormal_muscle_relaxation0.43016841
138MP0002085_abnormal_embryonic_tissue0.42637247
139MP0005464_abnormal_platelet_physiology0.42477210
140MP0008770_decreased_survivor_rate0.41964080
141MP0002452_abnormal_antigen_presenting0.40666258
142MP0004197_abnormal_fetal_growth/weight/0.40357559
143MP0000490_abnormal_crypts_of0.38984018
144MP0005174_abnormal_tail_pigmentation0.38449862
145MP0006035_abnormal_mitochondrial_morpho0.38393614
146MP0002169_no_abnormal_phenotype0.37362460
147MP0002693_abnormal_pancreas_physiology0.37172564
148MP0003656_abnormal_erythrocyte_physiolo0.37031093
149MP0002873_normal_phenotype0.36916128
150MP0002086_abnormal_extraembryonic_tissu0.35894966
151MP0004145_abnormal_muscle_electrophysio0.34898198
152MP0005025_abnormal_response_to0.34334784
153MP0001984_abnormal_olfaction0.32949142

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.31525177
2Abnormal respiratory motile cilium morphology (HP:0005938)8.31525177
3Abnormal respiratory motile cilium physiology (HP:0012261)8.05512822
4Chronic bronchitis (HP:0004469)7.32718943
5Nasal polyposis (HP:0100582)7.10377789
6Rhinitis (HP:0012384)7.02545757
7Infertility (HP:0000789)6.77529312
8Abnormal ciliary motility (HP:0012262)5.80736520
9Abnormality of the nasal mucosa (HP:0000433)5.77930841
10Bronchitis (HP:0012387)5.27091550
11Male infertility (HP:0003251)4.65408407
12Bronchiectasis (HP:0002110)4.48541574
13Nephronophthisis (HP:0000090)4.06507886
14Recurrent bronchitis (HP:0002837)3.90006622
15Abnormal spermatogenesis (HP:0008669)3.80259521
16Recurrent sinusitis (HP:0011108)3.52570100
17Recurrent otitis media (HP:0000403)3.49579854
18Achilles tendon contracture (HP:0001771)3.37885001
19Impulsivity (HP:0100710)3.35355978
20Upper motor neuron abnormality (HP:0002127)3.02826120
21Abnormality of the Achilles tendon (HP:0005109)3.02019389
22Abnormality of the renal medulla (HP:0100957)2.98832311
23Broad face (HP:0000283)2.96991600
24Progressive muscle weakness (HP:0003323)2.96894254
25J-shaped sella turcica (HP:0002680)2.89047473
26Ulnar bowing (HP:0003031)2.78085639
27Vaginal fistula (HP:0004320)2.74218984
28Intestinal fistula (HP:0100819)2.74158112
29Annular pancreas (HP:0001734)2.66910344
30Rectal fistula (HP:0100590)2.60319948
31Rectovaginal fistula (HP:0000143)2.60319948
32Truncus arteriosus (HP:0001660)2.56358611
33Broad distal phalanx of finger (HP:0009836)2.55984380
34Distal upper limb amyotrophy (HP:0007149)2.55956754
35Upper limb amyotrophy (HP:0009129)2.55956754
36Abnormality of liposaccharide metabolism (HP:0010968)2.55060460
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.55060460
38Abnormality of glycolipid metabolism (HP:0010969)2.55060460
39Abnormality of the costochondral junction (HP:0000919)2.54247785
40Tubular atrophy (HP:0000092)2.54091535
41Testicular atrophy (HP:0000029)2.53053683
42Increased serum ferritin (HP:0003281)2.50712419
43Cholecystitis (HP:0001082)2.49282667
44Abnormal gallbladder physiology (HP:0012438)2.49282667
45Recurrent viral infections (HP:0004429)2.48220696
46Polygenic inheritance (HP:0010982)2.46697502
47Colitis (HP:0002583)2.45896213
48Microretrognathia (HP:0000308)2.44639237
49Thin bony cortex (HP:0002753)2.41570502
50Tetany (HP:0001281)2.39808721
51Joint stiffness (HP:0001387)2.39789936
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.39033392
53Dysostosis multiplex (HP:0000943)2.37325290
54Tubulointerstitial nephritis (HP:0001970)2.36427178
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36072706
56Abnormality of polysaccharide metabolism (HP:0011012)2.36072706
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36072706
58Recurrent bacterial skin infections (HP:0005406)2.33012793
59Tubulointerstitial abnormality (HP:0001969)2.31160577
60Ragged-red muscle fibers (HP:0003200)2.29850871
61Recurrent abscess formation (HP:0002722)2.28179353
62Gastrointestinal stroma tumor (HP:0100723)2.27359534
63Pseudobulbar signs (HP:0002200)2.26298669
64Pallor (HP:0000980)2.25649760
65Breast hypoplasia (HP:0003187)2.25144754
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24230912
67Molar tooth sign on MRI (HP:0002419)2.23717871
68Abnormality of midbrain morphology (HP:0002418)2.23717871
69Birth length less than 3rd percentile (HP:0003561)2.21282594
70Hypokinesia (HP:0002375)2.19485509
71Progressive neurologic deterioration (HP:0002344)2.17405176
72Gonadotropin excess (HP:0000837)2.17326908
73Azoospermia (HP:0000027)2.16323447
74Viral hepatitis (HP:0006562)2.14994535
75Heterotopia (HP:0002282)2.14071013
76Facial hemangioma (HP:0000329)2.13469921
77Squamous cell carcinoma (HP:0002860)2.13148076
78Urinary glycosaminoglycan excretion (HP:0003541)2.11735133
79Mucopolysacchariduria (HP:0008155)2.11735133
80Stridor (HP:0010307)2.11725608
81Hyperacusis (HP:0010780)2.10919758
82Acute lymphatic leukemia (HP:0006721)2.09685504
83Abnormal number of erythroid precursors (HP:0012131)2.08397677
84Cervical subluxation (HP:0003308)2.06877345
85Biconcave vertebral bodies (HP:0004586)2.04255053
86Tubulointerstitial fibrosis (HP:0005576)2.04171664
87Myopathic facies (HP:0002058)2.03826670
88Hypertensive crisis (HP:0100735)2.03405594
89Dyschromatopsia (HP:0007641)2.01305459
90Abnormality of reticulocytes (HP:0004312)2.00162523
91Absent/shortened dynein arms (HP:0200106)12.1003527
92Dynein arm defect of respiratory motile cilia (HP:0012255)12.1003527
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7542238
94Thrombocytosis (HP:0001894)1.98705924
95Increased cerebral lipofuscin (HP:0011813)1.98419575
96Abnormality of cells of the erythroid lineage (HP:0012130)1.98018945
97Hypoparathyroidism (HP:0000829)1.94633638
98Abnormality of the fingertips (HP:0001211)1.94091015
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.93492287
100Choroideremia (HP:0001139)1.93007052
101Obstructive sleep apnea (HP:0002870)1.91689093
102Multiple enchondromatosis (HP:0005701)1.91579506
103Double outlet right ventricle (HP:0001719)1.90683357
104Congenital malformation of the right heart (HP:0011723)1.90683357
105Dysautonomia (HP:0002459)1.89833453
106Spastic tetraparesis (HP:0001285)1.89559474
107Obstructive lung disease (HP:0006536)1.87677113
108Chronic obstructive pulmonary disease (HP:0006510)1.87677113
109Trismus (HP:0000211)1.86847632
110Gastrointestinal inflammation (HP:0004386)1.86550510
111Emphysema (HP:0002097)1.86375671
112Hepatosplenomegaly (HP:0001433)1.83752858
113Cerebellar dysplasia (HP:0007033)1.83182667
114Chronic sinusitis (HP:0011109)1.81472652
115Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79223021
116Microvesicular hepatic steatosis (HP:0001414)1.79161476
117Thoracic kyphosis (HP:0002942)1.78311189
118Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78157807
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77782322
120Absent epiphyses (HP:0010577)1.77782322
121Rectal prolapse (HP:0002035)1.77721419
122Poikiloderma (HP:0001029)1.77697693
123Abnormality of the thoracic spine (HP:0100711)1.76279010
124Abnormal trabecular bone morphology (HP:0100671)1.75975816
125Abnormality of the columella (HP:0009929)1.75718011
126Generalized aminoaciduria (HP:0002909)1.75287810
127Unilateral renal agenesis (HP:0000122)1.75006247
128Abnormality of the phalanges of the hallux (HP:0010057)1.73961619
129Rough bone trabeculation (HP:0100670)1.73156934
130Turricephaly (HP:0000262)1.72934635
131Villous atrophy (HP:0011473)1.72539772
132Abnormality of small intestinal villus morphology (HP:0011472)1.72539772
133Decreased central vision (HP:0007663)1.71883891
134Bulbar palsy (HP:0001283)1.68999603
135Cellulitis (HP:0100658)1.68538382
136Agammaglobulinemia (HP:0004432)1.68441762
137Gastrointestinal dysmotility (HP:0002579)1.68409620
138Absent hand (HP:0004050)1.68009442
139Abnormal drinking behavior (HP:0030082)1.67596086
140Polydipsia (HP:0001959)1.67596086
141Loss of speech (HP:0002371)1.67349811
142Cleft eyelid (HP:0000625)1.67087111
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64537573
144Chronic otitis media (HP:0000389)1.63039967
145Postaxial foot polydactyly (HP:0001830)1.62968073
146Facial cleft (HP:0002006)1.60730600
147Short ribs (HP:0000773)1.59184570
148Medial flaring of the eyebrow (HP:0010747)1.58483517
149Difficulty climbing stairs (HP:0003551)1.54450956
150Myoglobinuria (HP:0002913)1.52464959
151Rhabdomyolysis (HP:0003201)1.51656520
152Easy fatigability (HP:0003388)1.51216942
153Abnormality of the lower motor neuron (HP:0002366)1.49004717
154Hemorrhage of the eye (HP:0011885)1.48977823
155Abnormality of the renal cortex (HP:0011035)1.48922797
156Stage 5 chronic kidney disease (HP:0003774)1.48037735
157Type II lissencephaly (HP:0007260)1.47937483
158Constricted visual fields (HP:0001133)1.47815797
159Oculomotor apraxia (HP:0000657)1.46611145
160Panhypogammaglobulinemia (HP:0003139)1.46336422
161Deformed sella turcica (HP:0002681)1.45803341
162Abnormality of renal excretion (HP:0011036)1.45490162
163Amyotrophic lateral sclerosis (HP:0007354)1.41921341
164Personality changes (HP:0000751)1.41183638
165Degeneration of anterior horn cells (HP:0002398)1.40281542
166Abnormality of the anterior horn cell (HP:0006802)1.40281542
167Bile duct proliferation (HP:0001408)1.36425893
168Abnormal biliary tract physiology (HP:0012439)1.36425893
169Renal dysplasia (HP:0000110)1.36079690
170Congenital hepatic fibrosis (HP:0002612)1.35752342
171Supernumerary spleens (HP:0009799)1.31631434
172Abnormal urine output (HP:0012590)1.31548551
173Neoplasm of the heart (HP:0100544)1.29388233
174Abnormality of ocular smooth pursuit (HP:0000617)1.29113758
175EMG: neuropathic changes (HP:0003445)1.27314360
176Generalized muscle weakness (HP:0003324)1.24659681
177Truncal obesity (HP:0001956)1.23766643
178Global brain atrophy (HP:0002283)1.23318571
179Acute myeloid leukemia (HP:0004808)1.22054039
180Hypoplasia of the thymus (HP:0000778)1.21817389
181Retinal dysplasia (HP:0007973)1.21318949
182Attenuation of retinal blood vessels (HP:0007843)1.21085459
183Bundle branch block (HP:0011710)1.20986172
184Reticulocytosis (HP:0001923)1.19233618
185Short femoral neck (HP:0100864)1.18709321
186Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.18475571
187Hemiparesis (HP:0001269)1.18329011
188Ulnar deviation of the wrist (HP:0003049)1.17397279
189Hand muscle atrophy (HP:0009130)1.17125712
190Asymmetric septal hypertrophy (HP:0001670)1.15733059
191Polyuria (HP:0000103)1.14360051
192Fatigue (HP:0012378)1.13738931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK16.79594260
2PDK36.36844345
3PDK46.36844345
4PRKD35.80441908
5SMG14.99534358
6ICK4.71424099
7PDK23.85688446
8PRPF4B3.34662496
9IRAK33.26957951
10NEK22.40545783
11VRK22.24484602
12ERN12.20597083
13EEF2K2.06696467
14SIK12.03144809
15PTK2B2.01253698
16TAOK21.99642356
17PASK1.75746805
18PNCK1.75187344
19MAP4K11.66645825
20STK381.57088551
21WNK41.52400481
22RPS6KB21.41380258
23CDC71.39542223
24DYRK1B1.33784592
25SCYL21.30110422
26TBK11.27880281
27MAP3K101.27278169
28STK391.20047128
29TESK21.20019952
30PDK11.18628608
31CCNB11.15920547
32DYRK31.15457465
33PIM21.14625367
34MAPK111.09641997
35IRAK41.09525662
36WEE11.08209024
37KDR1.07322618
38MAP3K131.05613429
39MAP3K141.05056466
40BLK1.04086867
41ABL21.01014209
42TRIB31.00051351
43ARAF0.98914748
44RIPK40.89225002
45STK40.88897108
46IRAK20.83478548
47ZAP700.83361364
48TTK0.77544067
49PDPK10.76044471
50BRAF0.75468525
51ATR0.74651790
52MELK0.74426160
53MAP3K10.73603558
54IKBKE0.72061604
55BUB10.71260740
56IKBKB0.70029049
57STK100.69510925
58EPHA20.68674824
59SIK20.68482133
60PRKD20.68394656
61KSR20.67460248
62HIPK20.66754244
63MST1R0.66280194
64CHEK10.65865755
65TAF10.65604758
66BRSK10.62910093
67MAP3K30.62803271
68CHEK20.62775576
69BMX0.61375777
70STK160.61067833
71EIF2AK10.60150206
72CDK40.59332876
73STK30.57095364
74TTN0.55833531
75CDC42BPA0.53438885
76PTK60.52663226
77PAK20.52556005
78TYRO30.52055614
79PAK40.51535817
80IRAK10.51462435
81MATK0.49784619
82MAP2K60.47948184
83MAPK150.47361391
84TLK10.47360500
85CLK10.46781683
86NME20.46495896
87ATM0.46279278
88MAP2K20.46190826
89CSF1R0.45534325
90ILK0.45453351
91TNK20.45450128
92PAK10.44824551
93FGFR40.44367812
94BTK0.44281152
95PLK40.43994871
96WNK10.43740757
97MTOR0.43686620
98PKN20.43448568
99MAPKAPK20.43262898
100KIT0.43038803
101CSK0.43016200
102CDK90.41991533
103BRSK20.40863621
104MAPKAPK30.40771243
105EIF2AK20.38935103
106DAPK10.38624855
107BMPR20.37301827
108MARK20.36947878
109PLK10.36281512
110PIM10.36007818
111TYK20.35975380
112NME10.35645323
113RIPK10.35022917
114TAOK10.34473219
115MUSK0.31800646
116RPS6KA10.31725727
117CDK120.30911324
118CDK60.30442004
119MAP2K30.29826223
120CAMK1G0.29802480
121RPS6KA40.28187369
122FLT30.28117473
123GRK60.26899409
124CDK20.26238971
125STK38L0.26138498
126SRPK10.26036647
127SYK0.25992015
128MAP3K110.25781586
129RPS6KA20.25729874
130MAP3K80.24777833
131CSNK2A20.23258883
132MARK30.22546619
133MAPK40.22430397
134ALK0.22183533
135CAMKK10.22003021
136TSSK60.21726585
137CDK70.21490752
138AURKB0.20427123
139PRKG20.18955625
140CSNK2A10.17833492
141RPS6KB10.17310149
142RPS6KC10.17175661
143RPS6KL10.17175661
144PINK10.17010995
145LRRK20.16888723
146LCK0.16236737
147AURKA0.15704460
148JAK30.15320374
149ACVR1B0.14722362
150BRD40.13936041
151RPS6KA60.13889454
152PRKCG0.13638868

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.87162777
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.84622782
3Fatty acid biosynthesis_Homo sapiens_hsa000613.69392051
4DNA replication_Homo sapiens_hsa030303.25798505
5Vitamin B6 metabolism_Homo sapiens_hsa007503.19805490
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59878189
7Pyruvate metabolism_Homo sapiens_hsa006202.46721473
8Selenocompound metabolism_Homo sapiens_hsa004502.43632291
9RNA transport_Homo sapiens_hsa030132.41526211
10Glucagon signaling pathway_Homo sapiens_hsa049222.27361636
11Basal transcription factors_Homo sapiens_hsa030222.22029770
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19387498
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12364021
14Fanconi anemia pathway_Homo sapiens_hsa034602.11965278
15Linoleic acid metabolism_Homo sapiens_hsa005911.98115049
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96310455
17Antigen processing and presentation_Homo sapiens_hsa046121.94999779
18Bladder cancer_Homo sapiens_hsa052191.94751489
19mRNA surveillance pathway_Homo sapiens_hsa030151.91477747
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90738058
21Base excision repair_Homo sapiens_hsa034101.86571839
22Mismatch repair_Homo sapiens_hsa034301.86317067
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82671095
24Spliceosome_Homo sapiens_hsa030401.77095277
25Pyrimidine metabolism_Homo sapiens_hsa002401.74883524
26Chronic myeloid leukemia_Homo sapiens_hsa052201.74805646
27Oocyte meiosis_Homo sapiens_hsa041141.67022609
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.63986822
29Pentose phosphate pathway_Homo sapiens_hsa000301.61330723
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60578103
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57983249
32Fructose and mannose metabolism_Homo sapiens_hsa000511.57741120
33Homologous recombination_Homo sapiens_hsa034401.54451128
34Purine metabolism_Homo sapiens_hsa002301.52687494
35Propanoate metabolism_Homo sapiens_hsa006401.52674445
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.47637413
37Prion diseases_Homo sapiens_hsa050201.45263965
38Notch signaling pathway_Homo sapiens_hsa043301.44230465
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42740964
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42541714
41Sulfur relay system_Homo sapiens_hsa041221.39303307
42Glycerolipid metabolism_Homo sapiens_hsa005611.34289431
43RNA polymerase_Homo sapiens_hsa030201.33863515
44Non-homologous end-joining_Homo sapiens_hsa034501.32648557
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32493706
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31095045
47Carbon metabolism_Homo sapiens_hsa012001.28559247
48Non-small cell lung cancer_Homo sapiens_hsa052231.27201712
49Lysosome_Homo sapiens_hsa041421.26411347
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24058981
51Primary immunodeficiency_Homo sapiens_hsa053401.23843999
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.13967538
53Hepatitis B_Homo sapiens_hsa051611.13027019
54Biosynthesis of amino acids_Homo sapiens_hsa012301.12579317
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12024048
56RNA degradation_Homo sapiens_hsa030181.11865177
57Osteoclast differentiation_Homo sapiens_hsa043801.06872112
58Amphetamine addiction_Homo sapiens_hsa050311.06508401
59Cell cycle_Homo sapiens_hsa041101.06184633
60B cell receptor signaling pathway_Homo sapiens_hsa046621.05093106
61Pancreatic cancer_Homo sapiens_hsa052121.02588095
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99878660
63Hepatitis C_Homo sapiens_hsa051600.97831146
64Shigellosis_Homo sapiens_hsa051310.96801754
65Thyroid cancer_Homo sapiens_hsa052160.93012595
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91951254
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.90654061
68Fat digestion and absorption_Homo sapiens_hsa049750.89508510
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.89455030
70Apoptosis_Homo sapiens_hsa042100.89101065
71Nucleotide excision repair_Homo sapiens_hsa034200.89004151
72Dorso-ventral axis formation_Homo sapiens_hsa043200.88305141
73Leishmaniasis_Homo sapiens_hsa051400.87970449
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87755504
75One carbon pool by folate_Homo sapiens_hsa006700.87645782
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87455578
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86917366
78mTOR signaling pathway_Homo sapiens_hsa041500.86149570
79Glutathione metabolism_Homo sapiens_hsa004800.86111817
80Proteasome_Homo sapiens_hsa030500.85080177
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83372992
82PPAR signaling pathway_Homo sapiens_hsa033200.82168057
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81176476
84Legionellosis_Homo sapiens_hsa051340.80474992
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79288987
86Cardiac muscle contraction_Homo sapiens_hsa042600.78479995
87TNF signaling pathway_Homo sapiens_hsa046680.77594386
88Herpes simplex infection_Homo sapiens_hsa051680.76980187
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76311870
90African trypanosomiasis_Homo sapiens_hsa051430.74019314
91Ribosome_Homo sapiens_hsa030100.72132285
92Measles_Homo sapiens_hsa051620.71348535
93Epstein-Barr virus infection_Homo sapiens_hsa051690.68298277
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67505550
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66340865
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66122189
97Systemic lupus erythematosus_Homo sapiens_hsa053220.63805998
98Estrogen signaling pathway_Homo sapiens_hsa049150.63277632
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.62789582
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60923447
101Huntingtons disease_Homo sapiens_hsa050160.60332152
102Lysine degradation_Homo sapiens_hsa003100.60176648
103Fatty acid metabolism_Homo sapiens_hsa012120.58749263
104Fatty acid degradation_Homo sapiens_hsa000710.58300595
105Hedgehog signaling pathway_Homo sapiens_hsa043400.57505671
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.57495958
107T cell receptor signaling pathway_Homo sapiens_hsa046600.56737170
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55333327
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54553535
110Malaria_Homo sapiens_hsa051440.51741175
111Salmonella infection_Homo sapiens_hsa051320.51488212
112Pertussis_Homo sapiens_hsa051330.50919441
113ABC transporters_Homo sapiens_hsa020100.50831874
114Long-term potentiation_Homo sapiens_hsa047200.50123031
115Viral carcinogenesis_Homo sapiens_hsa052030.50046761
116Phenylalanine metabolism_Homo sapiens_hsa003600.49973293
117Small cell lung cancer_Homo sapiens_hsa052220.49812481
118Insulin signaling pathway_Homo sapiens_hsa049100.49589357
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.48176877
120HTLV-I infection_Homo sapiens_hsa051660.46225831
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46166236
122Glioma_Homo sapiens_hsa052140.45654439
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45069461
124Toxoplasmosis_Homo sapiens_hsa051450.44043831
125Tuberculosis_Homo sapiens_hsa051520.43689253
126N-Glycan biosynthesis_Homo sapiens_hsa005100.43508404
127AMPK signaling pathway_Homo sapiens_hsa041520.43252278
128MicroRNAs in cancer_Homo sapiens_hsa052060.42352832
129VEGF signaling pathway_Homo sapiens_hsa043700.41202505
130Insulin resistance_Homo sapiens_hsa049310.41164574
131Prostate cancer_Homo sapiens_hsa052150.41071359
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40811285
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.40282539
134Acute myeloid leukemia_Homo sapiens_hsa052210.40000557
135Vitamin digestion and absorption_Homo sapiens_hsa049770.39431066
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39415741
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.39194626
138Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39180155
139ErbB signaling pathway_Homo sapiens_hsa040120.38693620
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38368251
141Mineral absorption_Homo sapiens_hsa049780.35826158
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.35799243
143Ether lipid metabolism_Homo sapiens_hsa005650.33401961
144HIF-1 signaling pathway_Homo sapiens_hsa040660.33314652
145Alcoholism_Homo sapiens_hsa050340.29662973
146Arachidonic acid metabolism_Homo sapiens_hsa005900.29551090
147Galactose metabolism_Homo sapiens_hsa000520.28630881
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28466701
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27804679
150Thyroid hormone synthesis_Homo sapiens_hsa049180.27113052
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27049616
152p53 signaling pathway_Homo sapiens_hsa041150.26307599
153Insulin secretion_Homo sapiens_hsa049110.25459307
154Metabolic pathways_Homo sapiens_hsa011000.24213239
155Endocytosis_Homo sapiens_hsa041440.24060020
156Influenza A_Homo sapiens_hsa051640.22976408

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