ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	7.55506774
2	fucose catabolic process (GO:0019317)	4.28962823
3	L-fucose metabolic process (GO:0042354)	4.28962823
4	L-fucose catabolic process (GO:0042355)	4.28962823
5	negative regulation of telomere maintenance (GO:0032205)	4.14285768
6	response to pheromone (GO:0019236)	3.98083655
7	rRNA catabolic process (GO:0016075)	3.82525108
8	indolalkylamine metabolic process (GO:0006586)	3.81881155
9	kynurenine metabolic process (GO:0070189)	3.79837828
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.77577709
11	tryptophan catabolic process (GO:0006569)	3.67924794
12	indole-containing compound catabolic process (GO:0042436)	3.67924794
13	indolalkylamine catabolic process (GO:0046218)	3.67924794
14	synaptic transmission, cholinergic (GO:0007271)	3.53389296
15	DNA deamination (GO:0045006)	3.49068932
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.43719890
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.43691475
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.22282552
19	detection of light stimulus involved in visual perception (GO:0050908)	3.22282552
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20030739
21	tryptophan metabolic process (GO:0006568)	3.15250336
22	negative regulation by host of viral transcription (GO:0043922)	3.09985975
23	indole-containing compound metabolic process (GO:0042430)	3.04339569
24	neural tube formation (GO:0001841)	3.02069989
25	piRNA metabolic process (GO:0034587)	3.01197209
26	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.98407365
27	sulfation (GO:0051923)	2.94986797
28	neuronal action potential (GO:0019228)	2.94956186
29	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.93230839
30	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.93230839
31	auditory receptor cell stereocilium organization (GO:0060088)	2.93032959
32	primary amino compound metabolic process (GO:1901160)	2.86112041
33	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.83735608
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.83327583
35	NADH dehydrogenase complex assembly (GO:0010257)	2.83327583
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.83327583
37	epithelial cilium movement (GO:0003351)	2.82550338
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.80654654
39	motile cilium assembly (GO:0044458)	2.78949570
40	serotonin metabolic process (GO:0042428)	2.78668276
41	nonmotile primary cilium assembly (GO:0035058)	2.76310856
42	regulation of hippo signaling (GO:0035330)	2.75307177
43	adaptation of signaling pathway (GO:0023058)	2.75009610
44	centriole replication (GO:0007099)	2.73432227
45	regulation of telomere maintenance (GO:0032204)	2.72930168
46	inner ear receptor stereocilium organization (GO:0060122)	2.71449707
47	protein complex biogenesis (GO:0070271)	2.68241446
48	protein localization to cilium (GO:0061512)	2.67761425
49	cellular response to ATP (GO:0071318)	2.67037663
50	postsynaptic membrane organization (GO:0001941)	2.66329947
51	regulation of respiratory system process (GO:0044065)	2.65070757
52	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.63714795
53	negative regulation of T cell differentiation in thymus (GO:0033085)	2.61863343
54	protein-cofactor linkage (GO:0018065)	2.61815598
55	cellular ketone body metabolic process (GO:0046950)	2.61698510
56	regulation of mesoderm development (GO:2000380)	2.60726649
57	hindbrain development (GO:0030902)	2.60657377
58	regulation of cilium movement (GO:0003352)	2.59420539
59	platelet dense granule organization (GO:0060155)	2.58294945
60	regulation of action potential (GO:0098900)	2.58099944
61	negative regulation of mast cell activation (GO:0033004)	2.58093872
62	reflex (GO:0060004)	2.57932307
63	relaxation of smooth muscle (GO:0044557)	2.56778066
64	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55446239
65	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.54382294
66	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.53651812
67	rhodopsin mediated signaling pathway (GO:0016056)	2.53488589
68	positive regulation of fatty acid transport (GO:2000193)	2.52644252
69	positive regulation by host of viral transcription (GO:0043923)	2.51489498
70	reciprocal DNA recombination (GO:0035825)	2.50682262
71	reciprocal meiotic recombination (GO:0007131)	2.50682262
72	positive regulation of prostaglandin secretion (GO:0032308)	2.50595433
73	cellular biogenic amine catabolic process (GO:0042402)	2.50089669
74	amine catabolic process (GO:0009310)	2.50089669
75	protein polyglutamylation (GO:0018095)	2.49191352
76	pyrimidine nucleobase catabolic process (GO:0006208)	2.48840447
77	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.48746230
78	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.48746230
79	regulation of translation, ncRNA-mediated (GO:0045974)	2.48746230
80	membrane depolarization during action potential (GO:0086010)	2.48111152
81	nephron epithelium morphogenesis (GO:0072088)	2.46271481
82	nephron tubule morphogenesis (GO:0072078)	2.46271481
83	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.45499470
84	cilium morphogenesis (GO:0060271)	2.45406611
85	DNA methylation involved in gamete generation (GO:0043046)	2.45224773
86	cilium or flagellum-dependent cell motility (GO:0001539)	2.45194359
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.44845345
88	retinal cone cell development (GO:0046549)	2.44789845
89	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.43138603
90	activated T cell proliferation (GO:0050798)	2.42498183
91	multicellular organism reproduction (GO:0032504)	2.41977965
92	gamma-aminobutyric acid transport (GO:0015812)	2.41976499
93	cAMP catabolic process (GO:0006198)	2.41957253
94	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.41748136
95	ATP synthesis coupled proton transport (GO:0015986)	2.41748136
96	somite development (GO:0061053)	2.41024044
97	kidney morphogenesis (GO:0060993)	2.41001613
98	regulation of microtubule-based movement (GO:0060632)	2.38464003
99	axoneme assembly (GO:0035082)	2.37837426
100	respiratory chain complex IV assembly (GO:0008535)	2.37728289

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.85578563
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.64076923
3	VDR_22108803_ChIP-Seq_LS180_Human	3.52278456
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89576536
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.85742548
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68734821
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64313178
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.44798998
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28141963
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26391951
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.23558359
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.19103807
13	EWS_26573619_Chip-Seq_HEK293_Human	2.04960380
14	FUS_26573619_Chip-Seq_HEK293_Human	1.93554721
15	P300_19829295_ChIP-Seq_ESCs_Human	1.93230578
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91761765
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.87457042
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87381366
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.85458086
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.82447680
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78753097
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77208180
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75239487
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70713477
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69295850
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60446357
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57757135
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57352260
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.57263985
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.56360372
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51705911
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50671775
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50671775
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.50172377
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49432432
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48998300
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48299945
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45372311
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.44937840
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40794630
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39326818
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.39326818
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39022947
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.38124440
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37853398
46	AR_25329375_ChIP-Seq_VCAP_Human	1.37615139
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.37003895
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36127541
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35065522
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33404577
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32698286
52	MYC_18940864_ChIP-ChIP_HL60_Human	1.32366196
53	STAT3_23295773_ChIP-Seq_U87_Human	1.31460866
54	TCF4_23295773_ChIP-Seq_U87_Human	1.30782160
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29040106
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28823831
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25060737
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25060737
59	NCOR_22424771_ChIP-Seq_293T_Human	1.23048220
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22877830
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22398405
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22334994
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21412113
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21412113
65	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.21361073
66	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20874735
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.20603626
68	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19844499
69	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19791056
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19255430
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19081516
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18242192
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17201622
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16422380
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15638048
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14231935
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.13374013
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13312094
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.13226911
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.12075892
81	AR_21572438_ChIP-Seq_LNCaP_Human	1.08134971
82	AR_20517297_ChIP-Seq_VCAP_Human	1.06743257
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05911263
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05665088
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05286910
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04797283
87	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04391347
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04090361
89	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.03634873
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03073048
91	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02788368
92	DROSHA_22980978_ChIP-Seq_HELA_Human	1.02290966
93	MYC_19829295_ChIP-Seq_ESCs_Human	1.01403733
94	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00507230
95	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00118124
96	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.98809583
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96745654
98	ERA_21632823_ChIP-Seq_H3396_Human	0.96461885
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95064770
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95029495

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	2.71361686
2	MP0003195_calcinosis	2.62338780
3	MP0008877_abnormal_DNA_methylation	2.48215803
4	MP0001968_abnormal_touch/_nociception	2.43481115
5	MP0005551_abnormal_eye_electrophysiolog	2.36581738
6	MP0003136_yellow_coat_color	2.27505036
7	MP0001986_abnormal_taste_sensitivity	2.23691889
8	MP0004885_abnormal_endolymph	2.19009002
9	MP0002736_abnormal_nociception_after	2.16279742
10	MP0004142_abnormal_muscle_tone	2.07873782
11	MP0006292_abnormal_olfactory_placode	2.07424751
12	MP0006276_abnormal_autonomic_nervous	2.04385166
13	MP0002837_dystrophic_cardiac_calcinosis	2.03547782
14	MP0008872_abnormal_physiological_respon	1.98610166
15	MP0000569_abnormal_digit_pigmentation	1.97339649
16	MP0003880_abnormal_central_pattern	1.93596153
17	MP0009697_abnormal_copulation	1.92086573
18	MP0010386_abnormal_urinary_bladder	1.85886470
19	MP0001485_abnormal_pinna_reflex	1.82069001
20	MP0006072_abnormal_retinal_apoptosis	1.81317549
21	MP0002272_abnormal_nervous_system	1.70658582
22	MP0009745_abnormal_behavioral_response	1.70431612
23	MP0004133_heterotaxia	1.69904058
24	MP0004742_abnormal_vestibular_system	1.69016766
25	MP0009046_muscle_twitch	1.65578998
26	MP0005646_abnormal_pituitary_gland	1.65360296
27	MP0001501_abnormal_sleep_pattern	1.63888355
28	MP0001529_abnormal_vocalization	1.62130095
29	MP0002735_abnormal_chemical_nociception	1.59313178
30	MP0005253_abnormal_eye_physiology	1.58197958
31	MP0000631_abnormal_neuroendocrine_gland	1.57960338
32	MP0002938_white_spotting	1.54878748
33	MP0004043_abnormal_pH_regulation	1.54050687
34	MP0003646_muscle_fatigue	1.51123136
35	MP0008875_abnormal_xenobiotic_pharmacok	1.51049218
36	MP0003787_abnormal_imprinting	1.47973461
37	MP0001486_abnormal_startle_reflex	1.47387242
38	MP0005645_abnormal_hypothalamus_physiol	1.45441322
39	MP0002638_abnormal_pupillary_reflex	1.44520719
40	MP0004145_abnormal_muscle_electrophysio	1.44489561
41	MP0004147_increased_porphyrin_level	1.43377222
42	MP0000427_abnormal_hair_cycle	1.41946130
43	MP0002572_abnormal_emotion/affect_behav	1.40442404
44	MP0002234_abnormal_pharynx_morphology	1.39873812
45	MP0009379_abnormal_foot_pigmentation	1.38599268
46	MP0002653_abnormal_ependyma_morphology	1.37828690
47	MP0003011_delayed_dark_adaptation	1.33878922
48	MP0002733_abnormal_thermal_nociception	1.29995801
49	MP0005389_reproductive_system_phenotype	1.29827159
50	MP0005423_abnormal_somatic_nervous	1.28922235
51	MP0002876_abnormal_thyroid_physiology	1.28438768
52	MP0001919_abnormal_reproductive_system	1.28300385
53	MP0002064_seizures	1.26851884
54	MP0001970_abnormal_pain_threshold	1.26813085
55	MP0005085_abnormal_gallbladder_physiolo	1.24993886
56	MP0005084_abnormal_gallbladder_morpholo	1.24844504
57	MP0004924_abnormal_behavior	1.23801329
58	MP0005386_behavior/neurological_phenoty	1.23801329
59	MP0002557_abnormal_social/conspecific_i	1.22483170
60	MP0003635_abnormal_synaptic_transmissio	1.17090293
61	MP0000230_abnormal_systemic_arterial	1.16823555
62	MP0003283_abnormal_digestive_organ	1.14158659
63	MP0002277_abnormal_respiratory_mucosa	1.13839435
64	MP0002160_abnormal_reproductive_system	1.10651260
65	MP0001963_abnormal_hearing_physiology	1.10131364
66	MP0000372_irregular_coat_pigmentation	1.09258279
67	MP0000778_abnormal_nervous_system	1.09044473
68	MP0008995_early_reproductive_senescence	1.08763206
69	MP0002928_abnormal_bile_duct	1.06309137
70	MP0002067_abnormal_sensory_capabilities	1.06271874
71	MP0000049_abnormal_middle_ear	1.04800927
72	MP0002063_abnormal_learning/memory/cond	1.04712992
73	MP0001984_abnormal_olfaction	1.04543319
74	MP0002138_abnormal_hepatobiliary_system	1.04074266
75	MP0005410_abnormal_fertilization	1.04011474
76	MP0001664_abnormal_digestion	1.03440502
77	MP0005195_abnormal_posterior_eye	1.01548532
78	MP0000026_abnormal_inner_ear	0.98519795
79	MP0002909_abnormal_adrenal_gland	0.97316450
80	MP0002734_abnormal_mechanical_nocicepti	0.96802606
81	MP0001905_abnormal_dopamine_level	0.94720748
82	MP0003119_abnormal_digestive_system	0.93896146
83	MP0002752_abnormal_somatic_nervous	0.93515543
84	MP0003137_abnormal_impulse_conducting	0.92894538
85	MP0002693_abnormal_pancreas_physiology	0.89757579
86	MP0008058_abnormal_DNA_repair	0.89589646
87	MP0003698_abnormal_male_reproductive	0.88610671
88	MP0003878_abnormal_ear_physiology	0.88547906
89	MP0005377_hearing/vestibular/ear_phenot	0.88547906
90	MP0004215_abnormal_myocardial_fiber	0.87800341
91	MP0002184_abnormal_innervation	0.87431958
92	MP0005671_abnormal_response_to	0.85130126
93	MP0001873_stomach_inflammation	0.84397005
94	MP0001293_anophthalmia	0.83093958
95	MP0003252_abnormal_bile_duct	0.82759072
96	MP0001502_abnormal_circadian_rhythm	0.82167685
97	MP0004084_abnormal_cardiac_muscle	0.81955730
98	MP0001440_abnormal_grooming_behavior	0.80699669
99	MP0002751_abnormal_autonomic_nervous	0.78957164
100	MP0000538_abnormal_urinary_bladder	0.76968121

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.94964307
2	Pancreatic cysts (HP:0001737)	3.94518514
3	Molar tooth sign on MRI (HP:0002419)	3.83261949
4	Abnormality of midbrain morphology (HP:0002418)	3.83261949
5	Bilateral microphthalmos (HP:0007633)	3.63221809
6	Nephronophthisis (HP:0000090)	3.61590494
7	True hermaphroditism (HP:0010459)	3.59939614
8	Pancreatic fibrosis (HP:0100732)	3.50481228
9	Type II lissencephaly (HP:0007260)	3.47482494
10	Abnormality of the renal cortex (HP:0011035)	3.28172308
11	Fibular aplasia (HP:0002990)	3.12629937
12	Attenuation of retinal blood vessels (HP:0007843)	3.06700383
13	Abnormality of the renal medulla (HP:0100957)	3.00597559
14	Decreased circulating renin level (HP:0003351)	2.98546367
15	Absent/shortened dynein arms (HP:0200106)	2.98227964
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.98227964
17	Partial agenesis of the corpus callosum (HP:0001338)	2.97241178
18	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.95613173
19	Hypoplasia of the fovea (HP:0007750)	2.95613173
20	Concave nail (HP:0001598)	2.95307021
21	Congenital, generalized hypertrichosis (HP:0004540)	2.88232462
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.84814921
23	Chronic hepatic failure (HP:0100626)	2.84085819
24	Renal cortical cysts (HP:0000803)	2.80190474
25	Fibular hypoplasia (HP:0003038)	2.78625095
26	Medial flaring of the eyebrow (HP:0010747)	2.74297773
27	Tubular atrophy (HP:0000092)	2.67371746
28	Abolished electroretinogram (ERG) (HP:0000550)	2.65326368
29	Cystic liver disease (HP:0006706)	2.63068777
30	Hyperventilation (HP:0002883)	2.61375910
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.60709683
32	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.58662356
33	Decreased central vision (HP:0007663)	2.54095386
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.51590715
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.51590715
36	Pendular nystagmus (HP:0012043)	2.49374373
37	Abnormality of the fovea (HP:0000493)	2.43693682
38	Inability to walk (HP:0002540)	2.41936525
39	Lissencephaly (HP:0001339)	2.32943579
40	Bony spicule pigmentary retinopathy (HP:0007737)	2.32503136
41	Polydipsia (HP:0001959)	2.27650944
42	Abnormal drinking behavior (HP:0030082)	2.27650944
43	Cerebellar dysplasia (HP:0007033)	2.27543559
44	Gait imbalance (HP:0002141)	2.24856970
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24620242
46	Increased corneal curvature (HP:0100692)	2.23372719
47	Keratoconus (HP:0000563)	2.23372719
48	Sclerocornea (HP:0000647)	2.16033777
49	Congenital primary aphakia (HP:0007707)	2.13457991
50	Abnormal ciliary motility (HP:0012262)	2.11659594
51	Hypothermia (HP:0002045)	2.11580493
52	Metabolic alkalosis (HP:0200114)	2.09622656
53	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.08957399
54	Acute necrotizing encephalopathy (HP:0006965)	2.06138077
55	Methylmalonic acidemia (HP:0002912)	2.03268240
56	Mitochondrial inheritance (HP:0001427)	2.03214697
57	Large for gestational age (HP:0001520)	2.00207924
58	Abnormality of the pons (HP:0007361)	1.99110018
59	Broad ribs (HP:0000885)	1.98006925
60	Optic nerve hypoplasia (HP:0000609)	1.97296390
61	Polyuria (HP:0000103)	1.96998913
62	Anencephaly (HP:0002323)	1.96734339
63	Stomach cancer (HP:0012126)	1.95553983
64	Nephrogenic diabetes insipidus (HP:0009806)	1.95012983
65	Progressive inability to walk (HP:0002505)	1.93210265
66	Hypoplasia of the pons (HP:0012110)	1.91424496
67	Abnormality of renin-angiotensin system (HP:0000847)	1.90057785
68	Furrowed tongue (HP:0000221)	1.89173308
69	Optic disc pallor (HP:0000543)	1.89073453
70	Chronic sinusitis (HP:0011109)	1.88365808
71	Lipid accumulation in hepatocytes (HP:0006561)	1.87869207
72	Congenital hepatic fibrosis (HP:0002612)	1.87079167
73	Protruding tongue (HP:0010808)	1.86695846
74	Methylmalonic aciduria (HP:0012120)	1.86385087
75	Progressive cerebellar ataxia (HP:0002073)	1.86261472
76	Limb dystonia (HP:0002451)	1.84426163
77	Pachygyria (HP:0001302)	1.83320013
78	Colon cancer (HP:0003003)	1.83293494
79	Broad-based gait (HP:0002136)	1.83205685
80	Increased CSF lactate (HP:0002490)	1.82754715
81	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.82526143
82	Abnormality of alanine metabolism (HP:0010916)	1.82526143
83	Hyperalaninemia (HP:0003348)	1.82526143
84	Hyperglycinuria (HP:0003108)	1.82330970
85	Abnormal biliary tract physiology (HP:0012439)	1.82271204
86	Bile duct proliferation (HP:0001408)	1.82271204
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.81290770
88	Genital tract atresia (HP:0001827)	1.81156016
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.81116773
90	Febrile seizures (HP:0002373)	1.79265108
91	Acute encephalopathy (HP:0006846)	1.79240787
92	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78511294
93	Vaginal atresia (HP:0000148)	1.77363870
94	Hemiparesis (HP:0001269)	1.76587013
95	Progressive macrocephaly (HP:0004481)	1.76509279
96	Male pseudohermaphroditism (HP:0000037)	1.75447005
97	Chorioretinal atrophy (HP:0000533)	1.72858366
98	Increased hepatocellular lipid droplets (HP:0006565)	1.70956700
99	Focal motor seizures (HP:0011153)	1.70238671
100	Unilateral renal agenesis (HP:0000122)	1.69860038

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.88230373
2	ADRBK2	3.10015532
3	NUAK1	2.76772512
4	ZAK	2.70917573
5	WNK4	2.67743985
6	PINK1	2.45045136
7	GRK1	2.41775161
8	CASK	2.39653830
9	VRK2	2.35313841
10	INSRR	2.27014205
11	TXK	2.26078636
12	MAP4K2	2.22069675
13	TLK1	2.20723252
14	WNK3	2.14022359
15	TAF1	2.08844092
16	TAOK3	1.96820392
17	PNCK	1.92722971
18	ACVR1B	1.91575059
19	DAPK2	1.79238022
20	BMPR1B	1.74618819
21	MAPK13	1.68406109
22	VRK1	1.66617896
23	OXSR1	1.57584719
24	DYRK2	1.54571263
25	MAP3K4	1.50641214
26	CAMKK2	1.48754877
27	TNIK	1.43585694
28	STK39	1.41521101
29	MARK1	1.40529871
30	MAPK15	1.38308874
31	NTRK3	1.33979618
32	PRKG2	1.28007225
33	MAPKAPK5	1.18499988
34	PRKCG	1.01048729
35	ADRBK1	0.94212514
36	STK11	0.90175873
37	CSNK1G2	0.90166874
38	HIPK2	0.89948211
39	MUSK	0.89352801
40	STK38L	0.89127595
41	MAP2K2	0.89041153
42	NEK2	0.88866598
43	PAK3	0.88639865
44	TIE1	0.87240676
45	MAP2K6	0.84609469
46	PLK4	0.84119157
47	MAP2K7	0.80825187
48	PRKCE	0.79919256
49	MKNK2	0.78284695
50	IKBKB	0.77951403
51	NTRK2	0.74898579
52	TGFBR1	0.74527535
53	NME1	0.72500863
54	CSNK1G3	0.72353435
55	NLK	0.70546732
56	TEC	0.68779038
57	ITK	0.68623440
58	BCKDK	0.66071834
59	CSNK1G1	0.65411230
60	IRAK1	0.63287992
61	MAPKAPK3	0.62469539
62	PHKG1	0.61387933
63	PHKG2	0.61387933
64	PLK2	0.61023522
65	PLK3	0.60421815
66	CAMK1D	0.60008247
67	GRK5	0.59554594
68	PKN1	0.58524362
69	TSSK6	0.58191038
70	DYRK3	0.55520309
71	CAMK2A	0.54856702
72	PRKCQ	0.54564241
73	CDK19	0.52399333
74	MELK	0.52174367
75	KIT	0.50603577
76	CSNK1A1L	0.50284410
77	PTK2B	0.50084623
78	CAMK1	0.49747287
79	SYK	0.49517658
80	RPS6KA5	0.48525900
81	SIK2	0.48060372
82	PRKG1	0.47571775
83	PRKACA	0.46944856
84	CAMK1G	0.46712703
85	CHUK	0.46643415
86	WEE1	0.45543091
87	PIK3CA	0.41861481
88	TNK2	0.41256505
89	MKNK1	0.39405556
90	FGFR2	0.38196465
91	EPHA4	0.37899373
92	EPHA3	0.37689751
93	PRKAA1	0.36199939
94	IRAK4	0.35796658
95	RPS6KA6	0.35428613
96	PRKCA	0.34252972
97	GRK7	0.33945340
98	PRKAA2	0.33801946
99	PRKCI	0.32970932
100	DYRK1A	0.31732869

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.88859685
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.57697736
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.57305238
4	Nicotine addiction_Homo sapiens_hsa05033	2.50657480
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.44689413
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.40740876
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.21712898
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07317627
9	Parkinsons disease_Homo sapiens_hsa05012	2.04637011
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.99394750
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94441612
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91442128
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.88640848
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.87893093
15	Caffeine metabolism_Homo sapiens_hsa00232	1.86984670
16	Protein export_Homo sapiens_hsa03060	1.83058943
17	Homologous recombination_Homo sapiens_hsa03440	1.76307394
18	Taste transduction_Homo sapiens_hsa04742	1.69795514
19	Morphine addiction_Homo sapiens_hsa05032	1.68828993
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.68507140
21	Butanoate metabolism_Homo sapiens_hsa00650	1.64298442
22	Basal transcription factors_Homo sapiens_hsa03022	1.63246848
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61255487
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.59397110
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.55670606
26	Olfactory transduction_Homo sapiens_hsa04740	1.53142561
27	Ribosome_Homo sapiens_hsa03010	1.51030374
28	RNA polymerase_Homo sapiens_hsa03020	1.45571414
29	Circadian entrainment_Homo sapiens_hsa04713	1.44302267
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.40106107
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.39565764
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38045673
33	GABAergic synapse_Homo sapiens_hsa04727	1.35176247
34	Alzheimers disease_Homo sapiens_hsa05010	1.31944363
35	Huntingtons disease_Homo sapiens_hsa05016	1.31797885
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.29110046
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27693971
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.26506028
39	Serotonergic synapse_Homo sapiens_hsa04726	1.25428872
40	RNA degradation_Homo sapiens_hsa03018	1.23026789
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22239626
42	ABC transporters_Homo sapiens_hsa02010	1.20672974
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.18091890
44	Insulin secretion_Homo sapiens_hsa04911	1.16912586
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.12210996
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10456374
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10090829
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04858227
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.04365002
50	Salivary secretion_Homo sapiens_hsa04970	1.01977064
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.01635062
52	Retinol metabolism_Homo sapiens_hsa00830	1.01195844
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00957799
54	Peroxisome_Homo sapiens_hsa04146	0.99214662
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98039180
56	One carbon pool by folate_Homo sapiens_hsa00670	0.95197393
57	Propanoate metabolism_Homo sapiens_hsa00640	0.90345179
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.85015823
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.84115094
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.81273469
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79889677
62	Regulation of autophagy_Homo sapiens_hsa04140	0.79362310
63	Cocaine addiction_Homo sapiens_hsa05030	0.78186505
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77055403
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75237835
66	Cholinergic synapse_Homo sapiens_hsa04725	0.71579422
67	Histidine metabolism_Homo sapiens_hsa00340	0.69700989
68	Long-term depression_Homo sapiens_hsa04730	0.66125360
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63872722
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60409124
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60096713
72	Amphetamine addiction_Homo sapiens_hsa05031	0.60078634
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.59497809
74	Graft-versus-host disease_Homo sapiens_hsa05332	0.58915335
75	Purine metabolism_Homo sapiens_hsa00230	0.58098192
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56968288
77	Renin secretion_Homo sapiens_hsa04924	0.55714232
78	Metabolic pathways_Homo sapiens_hsa01100	0.52680595
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52675967
80	Sulfur metabolism_Homo sapiens_hsa00920	0.52266720
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50723775
82	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47241181
83	Asthma_Homo sapiens_hsa05310	0.46985726
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.45997259
85	Proteasome_Homo sapiens_hsa03050	0.45047655
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43486769
87	Gastric acid secretion_Homo sapiens_hsa04971	0.42769468
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40825008
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39990347
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37925412
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36374804
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.34852474
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.32266658
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.31702261
95	Mineral absorption_Homo sapiens_hsa04978	0.31467988
96	Allograft rejection_Homo sapiens_hsa05330	0.30961077
97	Sulfur relay system_Homo sapiens_hsa04122	0.30891029
98	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.30673366
99	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30607797
100	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.29913396

PRR23C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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