PRR23C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.55506774
2fucose catabolic process (GO:0019317)4.28962823
3L-fucose metabolic process (GO:0042354)4.28962823
4L-fucose catabolic process (GO:0042355)4.28962823
5negative regulation of telomere maintenance (GO:0032205)4.14285768
6response to pheromone (GO:0019236)3.98083655
7rRNA catabolic process (GO:0016075)3.82525108
8indolalkylamine metabolic process (GO:0006586)3.81881155
9kynurenine metabolic process (GO:0070189)3.79837828
10water-soluble vitamin biosynthetic process (GO:0042364)3.77577709
11tryptophan catabolic process (GO:0006569)3.67924794
12indole-containing compound catabolic process (GO:0042436)3.67924794
13indolalkylamine catabolic process (GO:0046218)3.67924794
14synaptic transmission, cholinergic (GO:0007271)3.53389296
15DNA deamination (GO:0045006)3.49068932
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43719890
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43691475
18detection of light stimulus involved in sensory perception (GO:0050962)3.22282552
19detection of light stimulus involved in visual perception (GO:0050908)3.22282552
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.20030739
21tryptophan metabolic process (GO:0006568)3.15250336
22negative regulation by host of viral transcription (GO:0043922)3.09985975
23indole-containing compound metabolic process (GO:0042430)3.04339569
24neural tube formation (GO:0001841)3.02069989
25piRNA metabolic process (GO:0034587)3.01197209
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98407365
27sulfation (GO:0051923)2.94986797
28neuronal action potential (GO:0019228)2.94956186
29mesenchymal cell differentiation involved in kidney development (GO:0072161)2.93230839
30mesenchymal cell differentiation involved in renal system development (GO:2001012)2.93230839
31auditory receptor cell stereocilium organization (GO:0060088)2.93032959
32primary amino compound metabolic process (GO:1901160)2.86112041
33negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83735608
34mitochondrial respiratory chain complex I assembly (GO:0032981)2.83327583
35NADH dehydrogenase complex assembly (GO:0010257)2.83327583
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83327583
37epithelial cilium movement (GO:0003351)2.82550338
38negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80654654
39motile cilium assembly (GO:0044458)2.78949570
40serotonin metabolic process (GO:0042428)2.78668276
41nonmotile primary cilium assembly (GO:0035058)2.76310856
42regulation of hippo signaling (GO:0035330)2.75307177
43adaptation of signaling pathway (GO:0023058)2.75009610
44centriole replication (GO:0007099)2.73432227
45regulation of telomere maintenance (GO:0032204)2.72930168
46inner ear receptor stereocilium organization (GO:0060122)2.71449707
47protein complex biogenesis (GO:0070271)2.68241446
48protein localization to cilium (GO:0061512)2.67761425
49cellular response to ATP (GO:0071318)2.67037663
50postsynaptic membrane organization (GO:0001941)2.66329947
51regulation of respiratory system process (GO:0044065)2.65070757
52regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63714795
53negative regulation of T cell differentiation in thymus (GO:0033085)2.61863343
54protein-cofactor linkage (GO:0018065)2.61815598
55cellular ketone body metabolic process (GO:0046950)2.61698510
56regulation of mesoderm development (GO:2000380)2.60726649
57hindbrain development (GO:0030902)2.60657377
58regulation of cilium movement (GO:0003352)2.59420539
59platelet dense granule organization (GO:0060155)2.58294945
60regulation of action potential (GO:0098900)2.58099944
61negative regulation of mast cell activation (GO:0033004)2.58093872
62reflex (GO:0060004)2.57932307
63relaxation of smooth muscle (GO:0044557)2.56778066
64preassembly of GPI anchor in ER membrane (GO:0016254)2.55446239
65positive regulation of oligodendrocyte differentiation (GO:0048714)2.54382294
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53651812
67rhodopsin mediated signaling pathway (GO:0016056)2.53488589
68positive regulation of fatty acid transport (GO:2000193)2.52644252
69positive regulation by host of viral transcription (GO:0043923)2.51489498
70reciprocal DNA recombination (GO:0035825)2.50682262
71reciprocal meiotic recombination (GO:0007131)2.50682262
72positive regulation of prostaglandin secretion (GO:0032308)2.50595433
73cellular biogenic amine catabolic process (GO:0042402)2.50089669
74amine catabolic process (GO:0009310)2.50089669
75protein polyglutamylation (GO:0018095)2.49191352
76pyrimidine nucleobase catabolic process (GO:0006208)2.48840447
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48746230
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.48746230
79regulation of translation, ncRNA-mediated (GO:0045974)2.48746230
80membrane depolarization during action potential (GO:0086010)2.48111152
81nephron epithelium morphogenesis (GO:0072088)2.46271481
82nephron tubule morphogenesis (GO:0072078)2.46271481
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.45499470
84cilium morphogenesis (GO:0060271)2.45406611
85DNA methylation involved in gamete generation (GO:0043046)2.45224773
86cilium or flagellum-dependent cell motility (GO:0001539)2.45194359
87mitochondrial respiratory chain complex assembly (GO:0033108)2.44845345
88retinal cone cell development (GO:0046549)2.44789845
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43138603
90activated T cell proliferation (GO:0050798)2.42498183
91multicellular organism reproduction (GO:0032504)2.41977965
92gamma-aminobutyric acid transport (GO:0015812)2.41976499
93cAMP catabolic process (GO:0006198)2.41957253
94energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41748136
95ATP synthesis coupled proton transport (GO:0015986)2.41748136
96somite development (GO:0061053)2.41024044
97kidney morphogenesis (GO:0060993)2.41001613
98regulation of microtubule-based movement (GO:0060632)2.38464003
99axoneme assembly (GO:0035082)2.37837426
100respiratory chain complex IV assembly (GO:0008535)2.37728289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.85578563
2EZH2_22144423_ChIP-Seq_EOC_Human3.64076923
3VDR_22108803_ChIP-Seq_LS180_Human3.52278456
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89576536
5GBX2_23144817_ChIP-Seq_PC3_Human2.85742548
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68734821
7IGF1R_20145208_ChIP-Seq_DFB_Human2.64313178
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44798998
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28141963
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26391951
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.23558359
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19103807
13EWS_26573619_Chip-Seq_HEK293_Human2.04960380
14FUS_26573619_Chip-Seq_HEK293_Human1.93554721
15P300_19829295_ChIP-Seq_ESCs_Human1.93230578
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91761765
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87457042
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87381366
19TAF15_26573619_Chip-Seq_HEK293_Human1.85458086
20ER_23166858_ChIP-Seq_MCF-7_Human1.82447680
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78753097
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77208180
23REST_21632747_ChIP-Seq_MESCs_Mouse1.75239487
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.70713477
25IRF1_19129219_ChIP-ChIP_H3396_Human1.69295850
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60446357
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.57757135
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57352260
29TP53_22573176_ChIP-Seq_HFKS_Human1.57263985
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56360372
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51705911
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50671775
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50671775
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.50172377
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49432432
36RNF2_27304074_Chip-Seq_NSC_Mouse1.48998300
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48299945
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45372311
39BCAT_22108803_ChIP-Seq_LS180_Human1.44937840
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.40794630
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39326818
42CBP_20019798_ChIP-Seq_JUKART_Human1.39326818
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39022947
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38124440
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37853398
46AR_25329375_ChIP-Seq_VCAP_Human1.37615139
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37003895
48SMAD4_21799915_ChIP-Seq_A2780_Human1.36127541
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.35065522
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33404577
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32698286
52MYC_18940864_ChIP-ChIP_HL60_Human1.32366196
53STAT3_23295773_ChIP-Seq_U87_Human1.31460866
54TCF4_23295773_ChIP-Seq_U87_Human1.30782160
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29040106
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28823831
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25060737
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.25060737
59NCOR_22424771_ChIP-Seq_293T_Human1.23048220
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22877830
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22398405
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22334994
63NANOG_19829295_ChIP-Seq_ESCs_Human1.21412113
64SOX2_19829295_ChIP-Seq_ESCs_Human1.21412113
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.21361073
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.20874735
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.20603626
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19844499
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19791056
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19255430
71RUNX2_22187159_ChIP-Seq_PCA_Human1.19081516
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.18242192
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.17201622
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16422380
75HOXB7_26014856_ChIP-Seq_BT474_Human1.15638048
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.14231935
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.13374013
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13312094
79TCF4_22108803_ChIP-Seq_LS180_Human1.13226911
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12075892
81AR_21572438_ChIP-Seq_LNCaP_Human1.08134971
82AR_20517297_ChIP-Seq_VCAP_Human1.06743257
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.05911263
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.05665088
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05286910
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04797283
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04391347
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.04090361
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.03634873
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03073048
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02788368
92DROSHA_22980978_ChIP-Seq_HELA_Human1.02290966
93MYC_19829295_ChIP-Seq_ESCs_Human1.01403733
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00507230
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.00118124
96SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98809583
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96745654
98ERA_21632823_ChIP-Seq_H3396_Human0.96461885
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95064770
100TAF2_19829295_ChIP-Seq_ESCs_Human0.95029495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology2.71361686
2MP0003195_calcinosis2.62338780
3MP0008877_abnormal_DNA_methylation2.48215803
4MP0001968_abnormal_touch/_nociception2.43481115
5MP0005551_abnormal_eye_electrophysiolog2.36581738
6MP0003136_yellow_coat_color2.27505036
7MP0001986_abnormal_taste_sensitivity2.23691889
8MP0004885_abnormal_endolymph2.19009002
9MP0002736_abnormal_nociception_after2.16279742
10MP0004142_abnormal_muscle_tone2.07873782
11MP0006292_abnormal_olfactory_placode2.07424751
12MP0006276_abnormal_autonomic_nervous2.04385166
13MP0002837_dystrophic_cardiac_calcinosis2.03547782
14MP0008872_abnormal_physiological_respon1.98610166
15MP0000569_abnormal_digit_pigmentation1.97339649
16MP0003880_abnormal_central_pattern1.93596153
17MP0009697_abnormal_copulation1.92086573
18MP0010386_abnormal_urinary_bladder1.85886470
19MP0001485_abnormal_pinna_reflex1.82069001
20MP0006072_abnormal_retinal_apoptosis1.81317549
21MP0002272_abnormal_nervous_system1.70658582
22MP0009745_abnormal_behavioral_response1.70431612
23MP0004133_heterotaxia1.69904058
24MP0004742_abnormal_vestibular_system1.69016766
25MP0009046_muscle_twitch1.65578998
26MP0005646_abnormal_pituitary_gland1.65360296
27MP0001501_abnormal_sleep_pattern1.63888355
28MP0001529_abnormal_vocalization1.62130095
29MP0002735_abnormal_chemical_nociception1.59313178
30MP0005253_abnormal_eye_physiology1.58197958
31MP0000631_abnormal_neuroendocrine_gland1.57960338
32MP0002938_white_spotting1.54878748
33MP0004043_abnormal_pH_regulation1.54050687
34MP0003646_muscle_fatigue1.51123136
35MP0008875_abnormal_xenobiotic_pharmacok1.51049218
36MP0003787_abnormal_imprinting1.47973461
37MP0001486_abnormal_startle_reflex1.47387242
38MP0005645_abnormal_hypothalamus_physiol1.45441322
39MP0002638_abnormal_pupillary_reflex1.44520719
40MP0004145_abnormal_muscle_electrophysio1.44489561
41MP0004147_increased_porphyrin_level1.43377222
42MP0000427_abnormal_hair_cycle1.41946130
43MP0002572_abnormal_emotion/affect_behav1.40442404
44MP0002234_abnormal_pharynx_morphology1.39873812
45MP0009379_abnormal_foot_pigmentation1.38599268
46MP0002653_abnormal_ependyma_morphology1.37828690
47MP0003011_delayed_dark_adaptation1.33878922
48MP0002733_abnormal_thermal_nociception1.29995801
49MP0005389_reproductive_system_phenotype1.29827159
50MP0005423_abnormal_somatic_nervous1.28922235
51MP0002876_abnormal_thyroid_physiology1.28438768
52MP0001919_abnormal_reproductive_system1.28300385
53MP0002064_seizures1.26851884
54MP0001970_abnormal_pain_threshold1.26813085
55MP0005085_abnormal_gallbladder_physiolo1.24993886
56MP0005084_abnormal_gallbladder_morpholo1.24844504
57MP0004924_abnormal_behavior1.23801329
58MP0005386_behavior/neurological_phenoty1.23801329
59MP0002557_abnormal_social/conspecific_i1.22483170
60MP0003635_abnormal_synaptic_transmissio1.17090293
61MP0000230_abnormal_systemic_arterial1.16823555
62MP0003283_abnormal_digestive_organ1.14158659
63MP0002277_abnormal_respiratory_mucosa1.13839435
64MP0002160_abnormal_reproductive_system1.10651260
65MP0001963_abnormal_hearing_physiology1.10131364
66MP0000372_irregular_coat_pigmentation1.09258279
67MP0000778_abnormal_nervous_system1.09044473
68MP0008995_early_reproductive_senescence1.08763206
69MP0002928_abnormal_bile_duct1.06309137
70MP0002067_abnormal_sensory_capabilities1.06271874
71MP0000049_abnormal_middle_ear1.04800927
72MP0002063_abnormal_learning/memory/cond1.04712992
73MP0001984_abnormal_olfaction1.04543319
74MP0002138_abnormal_hepatobiliary_system1.04074266
75MP0005410_abnormal_fertilization1.04011474
76MP0001664_abnormal_digestion1.03440502
77MP0005195_abnormal_posterior_eye1.01548532
78MP0000026_abnormal_inner_ear0.98519795
79MP0002909_abnormal_adrenal_gland0.97316450
80MP0002734_abnormal_mechanical_nocicepti0.96802606
81MP0001905_abnormal_dopamine_level0.94720748
82MP0003119_abnormal_digestive_system0.93896146
83MP0002752_abnormal_somatic_nervous0.93515543
84MP0003137_abnormal_impulse_conducting0.92894538
85MP0002693_abnormal_pancreas_physiology0.89757579
86MP0008058_abnormal_DNA_repair0.89589646
87MP0003698_abnormal_male_reproductive0.88610671
88MP0003878_abnormal_ear_physiology0.88547906
89MP0005377_hearing/vestibular/ear_phenot0.88547906
90MP0004215_abnormal_myocardial_fiber0.87800341
91MP0002184_abnormal_innervation0.87431958
92MP0005671_abnormal_response_to0.85130126
93MP0001873_stomach_inflammation0.84397005
94MP0001293_anophthalmia0.83093958
95MP0003252_abnormal_bile_duct0.82759072
96MP0001502_abnormal_circadian_rhythm0.82167685
97MP0004084_abnormal_cardiac_muscle0.81955730
98MP0001440_abnormal_grooming_behavior0.80699669
99MP0002751_abnormal_autonomic_nervous0.78957164
100MP0000538_abnormal_urinary_bladder0.76968121

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.94964307
2Pancreatic cysts (HP:0001737)3.94518514
3Molar tooth sign on MRI (HP:0002419)3.83261949
4Abnormality of midbrain morphology (HP:0002418)3.83261949
5Bilateral microphthalmos (HP:0007633)3.63221809
6Nephronophthisis (HP:0000090)3.61590494
7True hermaphroditism (HP:0010459)3.59939614
8Pancreatic fibrosis (HP:0100732)3.50481228
9Type II lissencephaly (HP:0007260)3.47482494
10Abnormality of the renal cortex (HP:0011035)3.28172308
11Fibular aplasia (HP:0002990)3.12629937
12Attenuation of retinal blood vessels (HP:0007843)3.06700383
13Abnormality of the renal medulla (HP:0100957)3.00597559
14Decreased circulating renin level (HP:0003351)2.98546367
15Absent/shortened dynein arms (HP:0200106)2.98227964
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.98227964
17Partial agenesis of the corpus callosum (HP:0001338)2.97241178
18Aplasia/Hypoplasia of the fovea (HP:0008060)2.95613173
19Hypoplasia of the fovea (HP:0007750)2.95613173
20Concave nail (HP:0001598)2.95307021
21Congenital, generalized hypertrichosis (HP:0004540)2.88232462
22Abnormal rod and cone electroretinograms (HP:0008323)2.84814921
23Chronic hepatic failure (HP:0100626)2.84085819
24Renal cortical cysts (HP:0000803)2.80190474
25Fibular hypoplasia (HP:0003038)2.78625095
26Medial flaring of the eyebrow (HP:0010747)2.74297773
27Tubular atrophy (HP:0000092)2.67371746
28Abolished electroretinogram (ERG) (HP:0000550)2.65326368
29Cystic liver disease (HP:0006706)2.63068777
30Hyperventilation (HP:0002883)2.61375910
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60709683
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58662356
33Decreased central vision (HP:0007663)2.54095386
34Abnormal respiratory epithelium morphology (HP:0012253)2.51590715
35Abnormal respiratory motile cilium morphology (HP:0005938)2.51590715
36Pendular nystagmus (HP:0012043)2.49374373
37Abnormality of the fovea (HP:0000493)2.43693682
38Inability to walk (HP:0002540)2.41936525
39Lissencephaly (HP:0001339)2.32943579
40Bony spicule pigmentary retinopathy (HP:0007737)2.32503136
41Polydipsia (HP:0001959)2.27650944
42Abnormal drinking behavior (HP:0030082)2.27650944
43Cerebellar dysplasia (HP:0007033)2.27543559
44Gait imbalance (HP:0002141)2.24856970
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24620242
46Increased corneal curvature (HP:0100692)2.23372719
47Keratoconus (HP:0000563)2.23372719
48Sclerocornea (HP:0000647)2.16033777
49Congenital primary aphakia (HP:0007707)2.13457991
50Abnormal ciliary motility (HP:0012262)2.11659594
51Hypothermia (HP:0002045)2.11580493
52Metabolic alkalosis (HP:0200114)2.09622656
53Aplasia/Hypoplasia of the fibula (HP:0006492)2.08957399
54Acute necrotizing encephalopathy (HP:0006965)2.06138077
55Methylmalonic acidemia (HP:0002912)2.03268240
56Mitochondrial inheritance (HP:0001427)2.03214697
57Large for gestational age (HP:0001520)2.00207924
58Abnormality of the pons (HP:0007361)1.99110018
59Broad ribs (HP:0000885)1.98006925
60Optic nerve hypoplasia (HP:0000609)1.97296390
61Polyuria (HP:0000103)1.96998913
62Anencephaly (HP:0002323)1.96734339
63Stomach cancer (HP:0012126)1.95553983
64Nephrogenic diabetes insipidus (HP:0009806)1.95012983
65Progressive inability to walk (HP:0002505)1.93210265
66Hypoplasia of the pons (HP:0012110)1.91424496
67Abnormality of renin-angiotensin system (HP:0000847)1.90057785
68Furrowed tongue (HP:0000221)1.89173308
69Optic disc pallor (HP:0000543)1.89073453
70Chronic sinusitis (HP:0011109)1.88365808
71Lipid accumulation in hepatocytes (HP:0006561)1.87869207
72Congenital hepatic fibrosis (HP:0002612)1.87079167
73Protruding tongue (HP:0010808)1.86695846
74Methylmalonic aciduria (HP:0012120)1.86385087
75Progressive cerebellar ataxia (HP:0002073)1.86261472
76Limb dystonia (HP:0002451)1.84426163
77Pachygyria (HP:0001302)1.83320013
78Colon cancer (HP:0003003)1.83293494
79Broad-based gait (HP:0002136)1.83205685
80Increased CSF lactate (HP:0002490)1.82754715
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82526143
82Abnormality of alanine metabolism (HP:0010916)1.82526143
83Hyperalaninemia (HP:0003348)1.82526143
84Hyperglycinuria (HP:0003108)1.82330970
85Abnormal biliary tract physiology (HP:0012439)1.82271204
86Bile duct proliferation (HP:0001408)1.82271204
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.81290770
88Genital tract atresia (HP:0001827)1.81156016
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.81116773
90Febrile seizures (HP:0002373)1.79265108
91Acute encephalopathy (HP:0006846)1.79240787
92Abnormal respiratory motile cilium physiology (HP:0012261)1.78511294
93Vaginal atresia (HP:0000148)1.77363870
94Hemiparesis (HP:0001269)1.76587013
95Progressive macrocephaly (HP:0004481)1.76509279
96Male pseudohermaphroditism (HP:0000037)1.75447005
97Chorioretinal atrophy (HP:0000533)1.72858366
98Increased hepatocellular lipid droplets (HP:0006565)1.70956700
99Focal motor seizures (HP:0011153)1.70238671
100Unilateral renal agenesis (HP:0000122)1.69860038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.88230373
2ADRBK23.10015532
3NUAK12.76772512
4ZAK2.70917573
5WNK42.67743985
6PINK12.45045136
7GRK12.41775161
8CASK2.39653830
9VRK22.35313841
10INSRR2.27014205
11TXK2.26078636
12MAP4K22.22069675
13TLK12.20723252
14WNK32.14022359
15TAF12.08844092
16TAOK31.96820392
17PNCK1.92722971
18ACVR1B1.91575059
19DAPK21.79238022
20BMPR1B1.74618819
21MAPK131.68406109
22VRK11.66617896
23OXSR11.57584719
24DYRK21.54571263
25MAP3K41.50641214
26CAMKK21.48754877
27TNIK1.43585694
28STK391.41521101
29MARK11.40529871
30MAPK151.38308874
31NTRK31.33979618
32PRKG21.28007225
33MAPKAPK51.18499988
34PRKCG1.01048729
35ADRBK10.94212514
36STK110.90175873
37CSNK1G20.90166874
38HIPK20.89948211
39MUSK0.89352801
40STK38L0.89127595
41MAP2K20.89041153
42NEK20.88866598
43PAK30.88639865
44TIE10.87240676
45MAP2K60.84609469
46PLK40.84119157
47MAP2K70.80825187
48PRKCE0.79919256
49MKNK20.78284695
50IKBKB0.77951403
51NTRK20.74898579
52TGFBR10.74527535
53NME10.72500863
54CSNK1G30.72353435
55NLK0.70546732
56TEC0.68779038
57ITK0.68623440
58BCKDK0.66071834
59CSNK1G10.65411230
60IRAK10.63287992
61MAPKAPK30.62469539
62PHKG10.61387933
63PHKG20.61387933
64PLK20.61023522
65PLK30.60421815
66CAMK1D0.60008247
67GRK50.59554594
68PKN10.58524362
69TSSK60.58191038
70DYRK30.55520309
71CAMK2A0.54856702
72PRKCQ0.54564241
73CDK190.52399333
74MELK0.52174367
75KIT0.50603577
76CSNK1A1L0.50284410
77PTK2B0.50084623
78CAMK10.49747287
79SYK0.49517658
80RPS6KA50.48525900
81SIK20.48060372
82PRKG10.47571775
83PRKACA0.46944856
84CAMK1G0.46712703
85CHUK0.46643415
86WEE10.45543091
87PIK3CA0.41861481
88TNK20.41256505
89MKNK10.39405556
90FGFR20.38196465
91EPHA40.37899373
92EPHA30.37689751
93PRKAA10.36199939
94IRAK40.35796658
95RPS6KA60.35428613
96PRKCA0.34252972
97GRK70.33945340
98PRKAA20.33801946
99PRKCI0.32970932
100DYRK1A0.31732869

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.88859685
2Linoleic acid metabolism_Homo sapiens_hsa005912.57697736
3Oxidative phosphorylation_Homo sapiens_hsa001902.57305238
4Nicotine addiction_Homo sapiens_hsa050332.50657480
5Nitrogen metabolism_Homo sapiens_hsa009102.44689413
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40740876
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21712898
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.07317627
9Parkinsons disease_Homo sapiens_hsa050122.04637011
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99394750
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94441612
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91442128
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88640848
14Tryptophan metabolism_Homo sapiens_hsa003801.87893093
15Caffeine metabolism_Homo sapiens_hsa002321.86984670
16Protein export_Homo sapiens_hsa030601.83058943
17Homologous recombination_Homo sapiens_hsa034401.76307394
18Taste transduction_Homo sapiens_hsa047421.69795514
19Morphine addiction_Homo sapiens_hsa050321.68828993
20Selenocompound metabolism_Homo sapiens_hsa004501.68507140
21Butanoate metabolism_Homo sapiens_hsa006501.64298442
22Basal transcription factors_Homo sapiens_hsa030221.63246848
23Cardiac muscle contraction_Homo sapiens_hsa042601.61255487
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59397110
25Ether lipid metabolism_Homo sapiens_hsa005651.55670606
26Olfactory transduction_Homo sapiens_hsa047401.53142561
27Ribosome_Homo sapiens_hsa030101.51030374
28RNA polymerase_Homo sapiens_hsa030201.45571414
29Circadian entrainment_Homo sapiens_hsa047131.44302267
30Primary immunodeficiency_Homo sapiens_hsa053401.40106107
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.39565764
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38045673
33GABAergic synapse_Homo sapiens_hsa047271.35176247
34Alzheimers disease_Homo sapiens_hsa050101.31944363
35Huntingtons disease_Homo sapiens_hsa050161.31797885
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29110046
37Fanconi anemia pathway_Homo sapiens_hsa034601.27693971
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26506028
39Serotonergic synapse_Homo sapiens_hsa047261.25428872
40RNA degradation_Homo sapiens_hsa030181.23026789
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22239626
42ABC transporters_Homo sapiens_hsa020101.20672974
43Glutamatergic synapse_Homo sapiens_hsa047241.18091890
44Insulin secretion_Homo sapiens_hsa049111.16912586
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12210996
46Arachidonic acid metabolism_Homo sapiens_hsa005901.10456374
47Chemical carcinogenesis_Homo sapiens_hsa052041.10090829
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04858227
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.04365002
50Salivary secretion_Homo sapiens_hsa049701.01977064
51Ovarian steroidogenesis_Homo sapiens_hsa049131.01635062
52Retinol metabolism_Homo sapiens_hsa008301.01195844
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00957799
54Peroxisome_Homo sapiens_hsa041460.99214662
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98039180
56One carbon pool by folate_Homo sapiens_hsa006700.95197393
57Propanoate metabolism_Homo sapiens_hsa006400.90345179
58Fat digestion and absorption_Homo sapiens_hsa049750.85015823
59Glycerolipid metabolism_Homo sapiens_hsa005610.84115094
60Calcium signaling pathway_Homo sapiens_hsa040200.81273469
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79889677
62Regulation of autophagy_Homo sapiens_hsa041400.79362310
63Cocaine addiction_Homo sapiens_hsa050300.78186505
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77055403
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.75237835
66Cholinergic synapse_Homo sapiens_hsa047250.71579422
67Histidine metabolism_Homo sapiens_hsa003400.69700989
68Long-term depression_Homo sapiens_hsa047300.66125360
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63872722
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.60409124
71Collecting duct acid secretion_Homo sapiens_hsa049660.60096713
72Amphetamine addiction_Homo sapiens_hsa050310.60078634
73Dopaminergic synapse_Homo sapiens_hsa047280.59497809
74Graft-versus-host disease_Homo sapiens_hsa053320.58915335
75Purine metabolism_Homo sapiens_hsa002300.58098192
76beta-Alanine metabolism_Homo sapiens_hsa004100.56968288
77Renin secretion_Homo sapiens_hsa049240.55714232
78Metabolic pathways_Homo sapiens_hsa011000.52680595
79Type I diabetes mellitus_Homo sapiens_hsa049400.52675967
80Sulfur metabolism_Homo sapiens_hsa009200.52266720
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50723775
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47241181
83Asthma_Homo sapiens_hsa053100.46985726
84cAMP signaling pathway_Homo sapiens_hsa040240.45997259
85Proteasome_Homo sapiens_hsa030500.45047655
86Vitamin digestion and absorption_Homo sapiens_hsa049770.43486769
87Gastric acid secretion_Homo sapiens_hsa049710.42769468
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40825008
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39990347
90Oxytocin signaling pathway_Homo sapiens_hsa049210.37925412
91Rheumatoid arthritis_Homo sapiens_hsa053230.36374804
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34852474
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32266658
94Antigen processing and presentation_Homo sapiens_hsa046120.31702261
95Mineral absorption_Homo sapiens_hsa049780.31467988
96Allograft rejection_Homo sapiens_hsa053300.30961077
97Sulfur relay system_Homo sapiens_hsa041220.30891029
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.30673366
99Autoimmune thyroid disease_Homo sapiens_hsa053200.30607797
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29913396

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