ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	7.85283493
2	regulation of RIG-I signaling pathway (GO:0039535)	6.84765240
3	histone lysine demethylation (GO:0070076)	6.75335478
4	positive regulation of meiosis (GO:0045836)	6.52080226
5	synaptonemal complex organization (GO:0070193)	6.50544803
6	synaptonemal complex assembly (GO:0007130)	6.33948998
7	histone demethylation (GO:0016577)	6.32684356
8	regulation of exit from mitosis (GO:0007096)	6.29842749
9	gonadal mesoderm development (GO:0007506)	6.26853612
10	negative regulation of Ras GTPase activity (GO:0034261)	6.21161438
11	positive regulation of meiotic cell cycle (GO:0051446)	6.14798550
12	multicellular organism reproduction (GO:0032504)	6.05453903
13	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.99804512
14	protein demethylation (GO:0006482)	5.62416684
15	protein dealkylation (GO:0008214)	5.62416684
16	N-terminal protein amino acid acetylation (GO:0006474)	5.51472983
17	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	5.11710299
18	protein K48-linked deubiquitination (GO:0071108)	5.08152895
19	positive regulation of catecholamine secretion (GO:0033605)	5.06315316
20	regulation of acrosome reaction (GO:0060046)	4.86069294
21	regulation of female receptivity (GO:0045924)	4.77869144
22	acrosome reaction (GO:0007340)	4.74372480
23	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.62574160
24	single fertilization (GO:0007338)	4.39964246
25	female mating behavior (GO:0060180)	4.05865139
26	chromosome organization involved in meiosis (GO:0070192)	4.01582531
27	male meiosis I (GO:0007141)	3.99092213
28	artery development (GO:0060840)	3.97076885
29	reproduction (GO:0000003)	3.96664205
30	male meiosis (GO:0007140)	3.94287497
31	protein K63-linked deubiquitination (GO:0070536)	3.90440128
32	outer ear morphogenesis (GO:0042473)	3.85659254
33	regulation of receptor binding (GO:1900120)	3.82392544
34	response to UV-C (GO:0010225)	3.79107590
35	binding of sperm to zona pellucida (GO:0007339)	3.66361568
36	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.63906935
37	aggressive behavior (GO:0002118)	3.63788858
38	centriole replication (GO:0007099)	3.63588337
39	regulation of ruffle assembly (GO:1900027)	3.58972419
40	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.55813150
41	intestinal epithelial cell development (GO:0060576)	3.53097235
42	piRNA metabolic process (GO:0034587)	3.53058940
43	regulation of uterine smooth muscle contraction (GO:0070472)	3.46438091
44	regulation of defense response to virus by host (GO:0050691)	3.45969683
45	regulation of meiosis (GO:0040020)	3.44688412
46	cilium movement (GO:0003341)	3.36110820
47	fertilization (GO:0009566)	3.35441914
48	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.33601843
49	indole-containing compound catabolic process (GO:0042436)	3.29959041
50	indolalkylamine catabolic process (GO:0046218)	3.29959041
51	tryptophan catabolic process (GO:0006569)	3.29959041
52	sphingomyelin metabolic process (GO:0006684)	3.28536973
53	epithelial cilium movement (GO:0003351)	3.27472694
54	mechanosensory behavior (GO:0007638)	3.25817339
55	auditory receptor cell differentiation (GO:0042491)	3.23710352
56	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.22218688
57	citrulline biosynthetic process (GO:0019240)	3.21415733
58	negative regulation of reproductive process (GO:2000242)	3.18607299
59	regulation of vitamin D biosynthetic process (GO:0060556)	3.16319906
60	mitochondrial RNA metabolic process (GO:0000959)	3.15036710
61	behavioral response to nicotine (GO:0035095)	3.14656020
62	centrosome duplication (GO:0051298)	3.12941509
63	spermatid development (GO:0007286)	3.12558784
64	protein kinase C signaling (GO:0070528)	3.12183657
65	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	3.12094920
66	calcium ion-dependent exocytosis (GO:0017156)	3.11415908
67	regulation of mRNA splicing, via spliceosome (GO:0048024)	3.08300575
68	meiosis I (GO:0007127)	3.05429827
69	regulation of mRNA 3-end processing (GO:0031440)	3.04371420
70	indolalkylamine metabolic process (GO:0006586)	3.03319215
71	regulation of mRNA processing (GO:0050684)	3.03192514
72	kynurenine metabolic process (GO:0070189)	3.03064728
73	C21-steroid hormone biosynthetic process (GO:0006700)	3.02522813
74	protein K6-linked ubiquitination (GO:0085020)	3.00949440
75	demethylation (GO:0070988)	3.00117266
76	positive regulation of humoral immune response (GO:0002922)	2.98305458
77	regulation of histone H3-K9 methylation (GO:0051570)	2.98142950
78	positive regulation of digestive system process (GO:0060456)	2.96616310
79	positive regulation of histone H3-K4 methylation (GO:0051571)	2.96545926
80	regulation of meiotic cell cycle (GO:0051445)	2.96408858
81	transcription from mitochondrial promoter (GO:0006390)	2.95593221
82	regulation of helicase activity (GO:0051095)	2.94111757
83	trivalent inorganic anion homeostasis (GO:0072506)	2.94040483
84	phosphate ion homeostasis (GO:0055062)	2.94040483
85	sperm-egg recognition (GO:0035036)	2.93827519
86	negative regulation of cell fate specification (GO:0009996)	2.92089682
87	inner ear receptor cell differentiation (GO:0060113)	2.91369706
88	drinking behavior (GO:0042756)	2.90268050
89	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.88651048
90	regulation of B cell receptor signaling pathway (GO:0050855)	2.86606191
91	exocrine pancreas development (GO:0031017)	2.86121014
92	meiotic cell cycle process (GO:1903046)	2.84430733
93	vitamin catabolic process (GO:0009111)	2.84419553
94	fat-soluble vitamin catabolic process (GO:0042363)	2.84419553
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.84333992
96	cellular anion homeostasis (GO:0030002)	2.83511568
97	meiotic cell cycle (GO:0051321)	2.83036059
98	cochlea development (GO:0090102)	2.79705642
99	microtubule severing (GO:0051013)	2.79280210
100	histone H3-K9 demethylation (GO:0033169)	18.0924834

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.85658936
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.31624848
3	VDR_22108803_ChIP-Seq_LS180_Human	3.82530144
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.70766547
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.66835075
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.48294989
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98833621
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.69667911
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53521683
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.44467798
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.33819868
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32930791
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.17494381
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.10681472
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.08403401
16	TOP2B_26459242_ChIP-Seq_MCF-7_Human	2.06285834
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.03518169
18	RXR_22108803_ChIP-Seq_LS180_Human	2.02719388
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00169070
20	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.99002483
21	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.95288276
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.85524865
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.76072342
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.75394420
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.74304999
26	TCF4_23295773_ChIP-Seq_U87_Human	1.74096459
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71314509
28	P300_19829295_ChIP-Seq_ESCs_Human	1.69357446
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.68430123
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.68076411
31	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.67633787
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.65483480
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.64438395
34	AR_25329375_ChIP-Seq_VCAP_Human	1.62883965
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62115168
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59360332
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.59124844
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58296141
39	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.58094094
40	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.57918521
41	CBP_21632823_ChIP-Seq_H3396_Human	1.57523346
42	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.55571316
43	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.54691702
44	AR_21572438_ChIP-Seq_LNCaP_Human	1.54687093
45	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.52212067
46	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.52007311
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.50392224
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50083896
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44874709
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43039016
51	STAT3_23295773_ChIP-Seq_U87_Human	1.42384529
52	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.41865178
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.41156161
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41028275
55	GATA3_26560356_Chip-Seq_TH1_Human	1.39838230
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.36097667
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35598666
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34420160
59	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.33457090
60	NCOR_22424771_ChIP-Seq_293T_Human	1.30975839
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29049595
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.28718027
63	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.28143572
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27874628
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23706253
66	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.20878605
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18381472
68	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15815491
69	ZNF274_21170338_ChIP-Seq_K562_Hela	1.15695724
70	SMRT_27268052_Chip-Seq_Bcells_Human	1.15083548
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13687224
72	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.12406587
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09742668
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08831120
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08621530
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.08621530
77	TP63_23658742_ChIP-Seq_EP156T_Human	1.08219959
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07964516
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06869900
80	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06660976
81	ER_23166858_ChIP-Seq_MCF-7_Human	1.06217032
82	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05784399
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04100047
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.02569458
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02080872
86	GF1_26923725_Chip-Seq_HPCs_Mouse	1.01537211
87	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.01369205
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00521051
89	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.00204758
90	CJUN_26792858_Chip-Seq_BT549_Human	0.99824642
91	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99612678
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99499905
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99477978
94	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.99192667
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98319568
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96641499
97	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.94633154
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94633154
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93502717
100	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93140738

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	6.88674108
2	MP0006292_abnormal_olfactory_placode	5.88424005
3	MP0000678_abnormal_parathyroid_gland	4.31611662
4	MP0002160_abnormal_reproductive_system	3.39277054
5	MP0003136_yellow_coat_color	3.28391682
6	MP0009379_abnormal_foot_pigmentation	3.25623676
7	MP0003950_abnormal_plasma_membrane	3.09603142
8	MP0005451_abnormal_body_composition	2.92042039
9	MP0000427_abnormal_hair_cycle	2.89243604
10	MP0003693_abnormal_embryo_hatching	2.80729721
11	MP0005410_abnormal_fertilization	2.69010879
12	MP0001666_abnormal_nutrient_absorption	2.58483710
13	MP0009840_abnormal_foam_cell	2.50590432
14	MP0006276_abnormal_autonomic_nervous	2.50189027
15	MP0003183_abnormal_peptide_metabolism	2.48072816
16	MP0005360_urolithiasis	2.43442851
17	MP0003866_abnormal_defecation	2.19308568
18	MP0001929_abnormal_gametogenesis	2.10980186
19	MP0001664_abnormal_digestion	2.09180498
20	MP0003938_abnormal_ear_development	1.96992347
21	MP0005220_abnormal_exocrine_pancreas	1.92357958
22	MP0003119_abnormal_digestive_system	1.89566920
23	MP0004742_abnormal_vestibular_system	1.88366403
24	MP0000049_abnormal_middle_ear	1.86157891
25	MP0001502_abnormal_circadian_rhythm	1.84585814
26	MP0001485_abnormal_pinna_reflex	1.80101891
27	MP0002210_abnormal_sex_determination	1.70201668
28	MP0003890_abnormal_embryonic-extraembry	1.68972647
29	MP0005389_reproductive_system_phenotype	1.67434939
30	MP0003699_abnormal_female_reproductive	1.64361947
31	MP0006072_abnormal_retinal_apoptosis	1.64292205
32	MP0002751_abnormal_autonomic_nervous	1.55433387
33	MP0003868_abnormal_feces_composition	1.50374183
34	MP0008058_abnormal_DNA_repair	1.50291252
35	MP0005551_abnormal_eye_electrophysiolog	1.45204690
36	MP0010094_abnormal_chromosome_stability	1.29576683
37	MP0003698_abnormal_male_reproductive	1.29245243
38	MP0002249_abnormal_larynx_morphology	1.25560623
39	MP0000653_abnormal_sex_gland	1.22357834
40	MP0000470_abnormal_stomach_morphology	1.20155522
41	MP0005647_abnormal_sex_gland	1.17539871
42	MP0001501_abnormal_sleep_pattern	1.13630521
43	MP0005645_abnormal_hypothalamus_physiol	1.11868497
44	MP0005646_abnormal_pituitary_gland	1.11655603
45	MP0000631_abnormal_neuroendocrine_gland	1.11226761
46	MP0002161_abnormal_fertility/fecundity	1.09982137
47	MP0002184_abnormal_innervation	1.08327072
48	MP0000372_irregular_coat_pigmentation	1.08034911
49	MP0001119_abnormal_female_reproductive	1.06486604
50	MP0010030_abnormal_orbit_morphology	1.06461941
51	MP0003763_abnormal_thymus_physiology	1.02971412
52	MP0002234_abnormal_pharynx_morphology	1.02013970
53	MP0005671_abnormal_response_to	1.01208051
54	MP0010386_abnormal_urinary_bladder	0.99613450
55	MP0002229_neurodegeneration	0.98730412
56	MP0000569_abnormal_digit_pigmentation	0.95408796
57	MP0001145_abnormal_male_reproductive	0.93435593
58	MP0000467_abnormal_esophagus_morphology	0.93267601
59	MP0003880_abnormal_central_pattern	0.92515138
60	MP0001873_stomach_inflammation	0.87249446
61	MP0003936_abnormal_reproductive_system	0.83245980
62	MP0002102_abnormal_ear_morphology	0.82978553
63	MP0002272_abnormal_nervous_system	0.81317981
64	MP0000230_abnormal_systemic_arterial	0.81263468
65	MP0005623_abnormal_meninges_morphology	0.79637633
66	MP0001440_abnormal_grooming_behavior	0.79530675
67	MP0002163_abnormal_gland_morphology	0.78543905
68	MP0002282_abnormal_trachea_morphology	0.77497141
69	MP0004233_abnormal_muscle_weight	0.77251060
70	MP0001286_abnormal_eye_development	0.75929120
71	MP0001542_abnormal_bone_strength	0.74738953
72	MP0009745_abnormal_behavioral_response	0.74547588
73	MP0001963_abnormal_hearing_physiology	0.72071873
74	MP0000647_abnormal_sebaceous_gland	0.71493888
75	MP0004043_abnormal_pH_regulation	0.69868100
76	MP0000778_abnormal_nervous_system	0.69686481
77	MP0003879_abnormal_hair_cell	0.69270583
78	MP0005253_abnormal_eye_physiology	0.69266299
79	MP0008875_abnormal_xenobiotic_pharmacok	0.69239776
80	MP0002693_abnormal_pancreas_physiology	0.67218792
81	MP0009384_cardiac_valve_regurgitation	0.66699757
82	MP0008872_abnormal_physiological_respon	0.64521968
83	MP0000026_abnormal_inner_ear	0.61268382
84	MP0002090_abnormal_vision	0.60436790
85	MP0002876_abnormal_thyroid_physiology	0.59871893
86	MP0004859_abnormal_synaptic_plasticity	0.58883443
87	MP0000534_abnormal_ureter_morphology	0.58773197
88	MP0002067_abnormal_sensory_capabilities	0.58456433
89	MP0003718_maternal_effect	0.58360642
90	MP0002277_abnormal_respiratory_mucosa	0.56490874
91	MP0001944_abnormal_pancreas_morphology	0.56246075
92	MP0005334_abnormal_fat_pad	0.56034270
93	MP0005195_abnormal_posterior_eye	0.53412562
94	MP0008877_abnormal_DNA_methylation	0.52536244
95	MP0003959_abnormal_lean_body	0.51775813
96	MP0002837_dystrophic_cardiac_calcinosis	0.51291922
97	MP0002736_abnormal_nociception_after	0.51006463
98	MP0008995_early_reproductive_senescence	0.48995750
99	MP0002108_abnormal_muscle_morphology	0.48690072
100	MP0001730_embryonic_growth_arrest	0.48552522

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	6.64448310
2	Median cleft lip (HP:0000161)	4.47808582
3	Abnormal number of incisors (HP:0011064)	4.37807328
4	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.32434635
5	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.32434635
6	B lymphocytopenia (HP:0010976)	3.93541733
7	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.81836835
8	Short tibia (HP:0005736)	3.76651072
9	Tetany (HP:0001281)	3.62371551
10	Abnormality of the corticospinal tract (HP:0002492)	3.61409471
11	Oligodactyly (hands) (HP:0001180)	3.56292605
12	Facial cleft (HP:0002006)	3.55280359
13	Microglossia (HP:0000171)	3.52980502
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.52322862
15	Abnormality of B cell number (HP:0010975)	3.50223327
16	Short chin (HP:0000331)	3.33252586
17	Abnormal auditory evoked potentials (HP:0006958)	3.28901367
18	Atonic seizures (HP:0010819)	3.20461827
19	Pancreatic fibrosis (HP:0100732)	3.20237473
20	Amelogenesis imperfecta (HP:0000705)	3.15330804
21	Congenital sensorineural hearing impairment (HP:0008527)	3.13859223
22	Metaphyseal dysplasia (HP:0100255)	3.08569928
23	Impulsivity (HP:0100710)	3.07723849
24	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.97876425
25	Abnormality of the nasal septum (HP:0000419)	2.97109568
26	Hyperphosphatemia (HP:0002905)	2.92818688
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.90218057
28	Chromsome breakage (HP:0040012)	2.86864197
29	Type I diabetes mellitus (HP:0100651)	2.81280194
30	Abnormality of chromosome stability (HP:0003220)	2.66324027
31	Adrenal hypoplasia (HP:0000835)	2.65239239
32	Submucous cleft hard palate (HP:0000176)	2.64616951
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.62148868
34	Maternal diabetes (HP:0009800)	2.57534831
35	Genital tract atresia (HP:0001827)	2.55817501
36	Autoimmune hemolytic anemia (HP:0001890)	2.54195141
37	Keratoconus (HP:0000563)	2.54094241
38	Increased corneal curvature (HP:0100692)	2.54094241
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51913272
40	Abnormality of alanine metabolism (HP:0010916)	2.51913272
41	Hyperalaninemia (HP:0003348)	2.51913272
42	Anterior segment dysgenesis (HP:0007700)	2.47538767
43	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.47224229
44	Abnormality of the incisor (HP:0000676)	2.46350372
45	Anhidrosis (HP:0000970)	2.40531282
46	Autoimmune thrombocytopenia (HP:0001973)	2.36255664
47	Gastrointestinal infarctions (HP:0005244)	2.36236788
48	Ectopic kidney (HP:0000086)	2.35176901
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.34884257
50	Retinal dysplasia (HP:0007973)	2.32712532
51	Decreased central vision (HP:0007663)	2.32644876
52	Partial agenesis of the corpus callosum (HP:0001338)	2.31574382
53	Abolished electroretinogram (ERG) (HP:0000550)	2.30684786
54	Medial flaring of the eyebrow (HP:0010747)	2.29250252
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.28948205
56	Abnormality of dental color (HP:0011073)	2.26712603
57	Abnormality of abdominal situs (HP:0011620)	2.26502090
58	Abdominal situs inversus (HP:0003363)	2.26502090
59	Abnormality of the ileum (HP:0001549)	2.23297105
60	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.23066195
61	Pendular nystagmus (HP:0012043)	2.21168861
62	Neurofibrillary tangles (HP:0002185)	2.20926987
63	Gastrointestinal atresia (HP:0002589)	2.18642760
64	Gaze-evoked nystagmus (HP:0000640)	2.14222582
65	Abnormal ciliary motility (HP:0012262)	2.11435142
66	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.09772151
67	Chronic bronchitis (HP:0004469)	2.09318200
68	Abnormality of the labia minora (HP:0012880)	2.08550205
69	Oligodactyly (HP:0012165)	2.07797464
70	Abnormality of the prostate (HP:0008775)	2.02570757
71	Congenital primary aphakia (HP:0007707)	2.01028866
72	Urinary bladder sphincter dysfunction (HP:0002839)	1.99708867
73	Gait imbalance (HP:0002141)	1.99078655
74	Absent thumb (HP:0009777)	1.97673051
75	Acute myeloid leukemia (HP:0004808)	1.96634727
76	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.94284457
77	Tetraparesis (HP:0002273)	1.93787088
78	Decreased subcutaneous fat (HP:0001002)	1.91123098
79	Attenuation of retinal blood vessels (HP:0007843)	1.90443731
80	Meckel diverticulum (HP:0002245)	1.90363344
81	Abnormality of midbrain morphology (HP:0002418)	1.89661013
82	Molar tooth sign on MRI (HP:0002419)	1.89661013
83	Poor coordination (HP:0002370)	1.89056676
84	Optic nerve hypoplasia (HP:0000609)	1.88557137
85	Lymphopenia (HP:0001888)	1.87124345
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85353924
87	Clubbing of toes (HP:0100760)	1.85340486
88	Microretrognathia (HP:0000308)	1.84308373
89	Reticulocytopenia (HP:0001896)	1.83861808
90	Abnormal respiratory motile cilium physiology (HP:0012261)	1.83659579
91	Short thumb (HP:0009778)	1.79539323
92	Nephrogenic diabetes insipidus (HP:0009806)	1.78824156
93	Glossoptosis (HP:0000162)	1.77334259
94	Male infertility (HP:0003251)	1.77152936
95	Multiple enchondromatosis (HP:0005701)	1.76811566
96	Rectal prolapse (HP:0002035)	1.74532526
97	Vaginal atresia (HP:0000148)	1.74471555
98	Hypoplasia of the radius (HP:0002984)	1.74024701
99	Prostate neoplasm (HP:0100787)	1.73924845
100	Fair hair (HP:0002286)	1.73875074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.18848327
2	TNIK	3.62172292
3	TAOK3	3.52886528
4	CDK12	3.29739655
5	PLK4	3.17678656
6	TEC	3.10126368
7	ZAK	2.81480304
8	AURKA	2.57059195
9	STK39	2.40617319
10	VRK1	2.38381297
11	CDK19	2.14001512
12	ICK	2.11392170
13	NUAK1	2.00419186
14	NLK	1.93978405
15	CDK8	1.93491968
16	TLK1	1.92634407
17	BMPR1B	1.87822700
18	EPHA4	1.79171683
19	FRK	1.77284246
20	ACVR1B	1.74438886
21	TTK	1.56257399
22	MELK	1.51340733
23	CDC7	1.43028705
24	LATS1	1.41970280
25	PRKD3	1.27444741
26	TRIM28	1.25866849
27	MARK2	1.19542053
28	PKN1	1.19049173
29	LATS2	1.18002660
30	MAP2K3	1.17057682
31	WNK1	1.12582750
32	IRAK1	1.11412940
33	OXSR1	1.09987745
34	MAP3K3	1.04983171
35	CHEK2	1.02396028
36	ITK	1.01517573
37	GRK1	0.98960002
38	GRK7	0.97657231
39	PIK3CA	0.94395988
40	PLK1	0.92999448
41	TBK1	0.91387233
42	SGK2	0.88881974
43	KDR	0.87440090
44	PIK3CG	0.86736927
45	SRPK1	0.85649055
46	AURKB	0.85468781
47	STK38L	0.76236704
48	MAPK13	0.74964544
49	PLK2	0.74920268
50	PBK	0.72765710
51	ADRBK2	0.71446205
52	WNK4	0.70122363
53	CDK4	0.68931879
54	TXK	0.67733666
55	DMPK	0.67220799
56	CDK7	0.63638414
57	MAP4K2	0.62156381
58	CAMK4	0.59436524
59	RPS6KA5	0.58551793
60	TESK2	0.58193488
61	CDK9	0.57069779
62	PRKD2	0.57031638
63	MAP3K7	0.56360484
64	STK24	0.55376811
65	MAPKAPK2	0.54350461
66	STK3	0.51514986
67	PIM2	0.50885348
68	PRKACA	0.50688183
69	RAF1	0.47943618
70	ILK	0.45764221
71	LIMK1	0.44540050
72	CSNK1D	0.43017533
73	GRK5	0.41881944
74	PIM1	0.39141429
75	NEK6	0.39123151
76	SGK223	0.38959178
77	SGK494	0.38959178
78	CAMK1	0.38881842
79	BRAF	0.38512176
80	JAK3	0.38381295
81	ARAF	0.38161450
82	PRKACB	0.36530819
83	CDK2	0.36287384
84	NME1	0.35865385
85	SGK3	0.35696695
86	BTK	0.35104102
87	MOS	0.34313084
88	PRKD1	0.34090843
89	PAK1	0.33745664
90	TYRO3	0.33044888
91	INSRR	0.32440815
92	CHEK1	0.32367973
93	CDK3	0.31298131
94	EPHB1	0.30460541
95	PRKAA1	0.30276619
96	STK4	0.29593497
97	IGF1R	0.28892201
98	PRKCA	0.28227999
99	PLK3	0.27410300
100	PRKCE	0.27287194

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	6.59190292
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.41291265
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.17595079
4	Mismatch repair_Homo sapiens_hsa03430	3.13329368
5	Homologous recombination_Homo sapiens_hsa03440	2.84103627
6	Ribosome_Homo sapiens_hsa03010	2.41724679
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.34987073
8	Bile secretion_Homo sapiens_hsa04976	2.24478584
9	RNA polymerase_Homo sapiens_hsa03020	2.16730197
10	Olfactory transduction_Homo sapiens_hsa04740	2.11906780
11	Phototransduction_Homo sapiens_hsa04744	2.07488350
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.02286949
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.89907011
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.84455804
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79131211
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.68490250
17	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.62396539
18	RNA degradation_Homo sapiens_hsa03018	1.58044271
19	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.54645885
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.47695497
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.46203757
22	Basal transcription factors_Homo sapiens_hsa03022	1.44526980
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.39478863
24	Retinol metabolism_Homo sapiens_hsa00830	1.37353119
25	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.31271704
26	Insulin secretion_Homo sapiens_hsa04911	1.25993409
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23102698
28	Oocyte meiosis_Homo sapiens_hsa04114	1.19219076
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14662754
30	Alcoholism_Homo sapiens_hsa05034	1.14612494
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.13015150
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11338564
33	Serotonergic synapse_Homo sapiens_hsa04726	1.09357857
34	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.03243336
35	Purine metabolism_Homo sapiens_hsa00230	1.02806972
36	Sulfur metabolism_Homo sapiens_hsa00920	1.02221873
37	Taste transduction_Homo sapiens_hsa04742	1.01617860
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00862080
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95629806
40	Nicotine addiction_Homo sapiens_hsa05033	0.92349704
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88125780
42	Colorectal cancer_Homo sapiens_hsa05210	0.87628551
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87541569
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86982545
45	mRNA surveillance pathway_Homo sapiens_hsa03015	0.86912909
46	Cholinergic synapse_Homo sapiens_hsa04725	0.86171494
47	RNA transport_Homo sapiens_hsa03013	0.84559612
48	Protein export_Homo sapiens_hsa03060	0.82579645
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81872461
50	DNA replication_Homo sapiens_hsa03030	0.79560886
51	GABAergic synapse_Homo sapiens_hsa04727	0.78846239
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.71933115
53	Cocaine addiction_Homo sapiens_hsa05030	0.69733157
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68142843
55	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67227813
56	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.66735308
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64884448
58	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.63803568
59	Morphine addiction_Homo sapiens_hsa05032	0.62851498
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.61504853
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.61348896
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.57240577
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56079494
64	Pancreatic secretion_Homo sapiens_hsa04972	0.53097831
65	Huntingtons disease_Homo sapiens_hsa05016	0.52767113
66	Dopaminergic synapse_Homo sapiens_hsa04728	0.52206002
67	Caffeine metabolism_Homo sapiens_hsa00232	0.50702832
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47368405
69	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46571690
70	Circadian entrainment_Homo sapiens_hsa04713	0.45944956
71	Circadian rhythm_Homo sapiens_hsa04710	0.44538286
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.41291539
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40252477
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40072498
75	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39255236
76	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.37667897
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.37663956
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.35654365
79	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35085431
80	Salivary secretion_Homo sapiens_hsa04970	0.31546156
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31295859
82	Butanoate metabolism_Homo sapiens_hsa00650	0.30311690
83	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30012721
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28871145
85	Herpes simplex infection_Homo sapiens_hsa05168	0.28206756
86	Regulation of autophagy_Homo sapiens_hsa04140	0.27397402
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26090414
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.25922700
89	PPAR signaling pathway_Homo sapiens_hsa03320	0.25122567
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.25076486
91	Tight junction_Homo sapiens_hsa04530	0.25012203
92	p53 signaling pathway_Homo sapiens_hsa04115	0.23602645
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.22206847
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.21886054
95	Lysine degradation_Homo sapiens_hsa00310	0.21356250
96	Renin secretion_Homo sapiens_hsa04924	0.21294527
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21073005
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.20914492
99	Cell cycle_Homo sapiens_hsa04110	0.20672793
100	Amphetamine addiction_Homo sapiens_hsa05031	0.20384523

PRR23D1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »