ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	7.10882248
2	regulation of RIG-I signaling pathway (GO:0039535)	6.20096133
3	histone lysine demethylation (GO:0070076)	6.00595155
4	positive regulation of meiosis (GO:0045836)	5.88204269
5	synaptonemal complex organization (GO:0070193)	5.83735033
6	negative regulation of Ras GTPase activity (GO:0034261)	5.78868177
7	synaptonemal complex assembly (GO:0007130)	5.69863633
8	gonadal mesoderm development (GO:0007506)	5.63796879
9	histone demethylation (GO:0016577)	5.61257680
10	regulation of exit from mitosis (GO:0007096)	5.60314782
11	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	5.59324306
12	sphingomyelin metabolic process (GO:0006684)	5.56290797
13	positive regulation of meiotic cell cycle (GO:0051446)	5.54783331
14	multicellular organism reproduction (GO:0032504)	5.50630342
15	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.40897490
16	auditory receptor cell differentiation (GO:0042491)	5.18667345
17	N-terminal protein amino acid acetylation (GO:0006474)	5.08229582
18	protein dealkylation (GO:0008214)	4.97353890
19	protein demethylation (GO:0006482)	4.97353890
20	regulation of B cell receptor signaling pathway (GO:0050855)	4.84024862
21	protein K48-linked deubiquitination (GO:0071108)	4.72321199
22	mechanosensory behavior (GO:0007638)	4.69345978
23	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	4.59378256
24	positive regulation of catecholamine secretion (GO:0033605)	4.52394441
25	regulation of vitamin D biosynthetic process (GO:0060556)	4.49731574
26	regulation of female receptivity (GO:0045924)	4.48874424
27	negative regulation of cell fate specification (GO:0009996)	4.47873386
28	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.44219924
29	artery development (GO:0060840)	4.42355902
30	outer ear morphogenesis (GO:0042473)	4.37026807
31	regulation of acrosome reaction (GO:0060046)	4.27721922
32	acrosome reaction (GO:0007340)	4.17083718
33	C21-steroid hormone biosynthetic process (GO:0006700)	4.06135822
34	regulation of receptor binding (GO:1900120)	3.90013292
35	single fertilization (GO:0007338)	3.87766776
36	inner ear receptor cell differentiation (GO:0060113)	3.82807268
37	histone H2A acetylation (GO:0043968)	3.77907816
38	aggressive behavior (GO:0002118)	3.77207977
39	female mating behavior (GO:0060180)	3.77148141
40	male meiosis I (GO:0007141)	3.68340651
41	regulation of vitamin metabolic process (GO:0030656)	3.68035980
42	protein K63-linked deubiquitination (GO:0070536)	3.65913494
43	chromosome organization involved in meiosis (GO:0070192)	3.53259994
44	behavioral response to nicotine (GO:0035095)	3.52692495
45	response to UV-C (GO:0010225)	3.52327330
46	reproduction (GO:0000003)	3.50369771
47	male meiosis (GO:0007140)	3.44539394
48	positive regulation of fatty acid oxidation (GO:0046321)	3.43720766
49	negative regulation of cell fate commitment (GO:0010454)	3.42850348
50	regulation of ruffle assembly (GO:1900027)	3.40552493
51	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.39338019
52	regulation of uterine smooth muscle contraction (GO:0070472)	3.33801567
53	intestinal epithelial cell development (GO:0060576)	3.31760743
54	indole-containing compound catabolic process (GO:0042436)	3.31476075
55	indolalkylamine catabolic process (GO:0046218)	3.31476075
56	tryptophan catabolic process (GO:0006569)	3.31476075
57	mechanoreceptor differentiation (GO:0042490)	3.30606406
58	hair cell differentiation (GO:0035315)	3.28891419
59	piRNA metabolic process (GO:0034587)	3.28869525
60	negative regulation of monooxygenase activity (GO:0032769)	3.27000634
61	centriole replication (GO:0007099)	3.26160639
62	protein prenylation (GO:0018342)	3.22548121
63	prenylation (GO:0097354)	3.22548121
64	binding of sperm to zona pellucida (GO:0007339)	3.20786608
65	centrosome duplication (GO:0051298)	3.15499195
66	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.14438106
67	cilium movement (GO:0003341)	3.09269668
68	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.08182925
69	negative regulation of mast cell activation (GO:0033004)	3.07396216
70	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.06938666
71	negative regulation of reproductive process (GO:2000242)	3.05483660
72	kynurenine metabolic process (GO:0070189)	3.05224464
73	regulation of defense response to virus by host (GO:0050691)	3.03970357
74	positive regulation of cell fate commitment (GO:0010455)	3.01719699
75	protein kinase C signaling (GO:0070528)	3.01002364
76	DNA alkylation (GO:0006305)	3.00909233
77	DNA methylation (GO:0006306)	3.00909233
78	regulation of meiosis (GO:0040020)	3.00552599
79	endoderm formation (GO:0001706)	2.97057465
80	fertilization (GO:0009566)	2.95266871
81	epithelial cilium movement (GO:0003351)	2.90979727
82	citrulline biosynthetic process (GO:0019240)	2.89837632
83	indolalkylamine metabolic process (GO:0006586)	2.89652104
84	lens fiber cell differentiation (GO:0070306)	2.87175373
85	meiosis I (GO:0007127)	2.85387963
86	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.83162138
87	spermatid development (GO:0007286)	2.83113899
88	regulation of histone H3-K9 methylation (GO:0051570)	2.81633376
89	calcium ion-dependent exocytosis (GO:0017156)	2.80200545
90	retinoic acid receptor signaling pathway (GO:0048384)	2.79699618
91	regulation of transforming growth factor beta2 production (GO:0032909)	2.78494150
92	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.77725055
93	regulation of mRNA processing (GO:0050684)	2.77506235
94	regulation of mRNA splicing, via spliceosome (GO:0048024)	2.76392645
95	exocrine pancreas development (GO:0031017)	2.76100626
96	DNA methylation involved in gamete generation (GO:0043046)	2.75662478
97	regulation of mRNA 3-end processing (GO:0031440)	2.74654055
98	mitochondrial RNA metabolic process (GO:0000959)	2.73821219
99	drinking behavior (GO:0042756)	2.70497031
100	histone H3-K9 demethylation (GO:0033169)	16.4491401

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.44101747
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.16140059
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.39731363
4	VDR_22108803_ChIP-Seq_LS180_Human	3.71365600
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.49518158
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.28939003
7	IGF1R_20145208_ChIP-Seq_DFB_Human	3.05782137
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.60499834
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.49233332
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.32023971
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.28632527
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.24878500
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.21779970
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12654093
15	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07177071
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03481750
17	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.97227476
18	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.96589522
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94994855
20	RXR_22108803_ChIP-Seq_LS180_Human	1.89809325
21	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.89009134
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.83684063
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.82361390
24	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.78502249
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.78179227
26	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.75174813
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74383165
28	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.73554882
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.70829633
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70514557
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.69903101
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.69774116
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69698960
34	P300_19829295_ChIP-Seq_ESCs_Human	1.62725553
35	AR_25329375_ChIP-Seq_VCAP_Human	1.61970805
36	TCF4_23295773_ChIP-Seq_U87_Human	1.58439632
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57430038
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.54802697
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.54490903
40	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.54249653
41	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.52003002
42	CBP_21632823_ChIP-Seq_H3396_Human	1.51586971
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51219386
44	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.50971034
45	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.49682436
46	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49053373
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47178813
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46947575
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.44313276
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.43699591
51	GATA3_26560356_Chip-Seq_TH1_Human	1.41011759
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.40687427
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.37885305
54	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.34964140
55	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.34093970
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33249110
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32095424
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.30541888
59	ZNF274_21170338_ChIP-Seq_K562_Hela	1.29453682
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25866847
61	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24837300
62	STAT3_23295773_ChIP-Seq_U87_Human	1.23691147
63	NCOR_22424771_ChIP-Seq_293T_Human	1.23314231
64	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23010313
65	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.22644269
66	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.21903388
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.21660785
68	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20761848
69	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.19268503
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15314220
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.15191694
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14191383
73	SMRT_27268052_Chip-Seq_Bcells_Human	1.12500374
74	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.11472346
75	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.10111835
76	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.09896233
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09883982
78	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.07654911
79	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07386719
80	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06195210
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05577400
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04702384
83	CBP_20019798_ChIP-Seq_JUKART_Human	1.04033564
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04033564
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03075801
86	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02869163
87	TP63_23658742_ChIP-Seq_EP156T_Human	1.02645648
88	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01514318
89	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01355660
90	EWS_26573619_Chip-Seq_HEK293_Human	1.00040273
91	CJUN_26792858_Chip-Seq_BT549_Human	1.00001117
92	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99343697
93	GATA4_25053715_ChIP-Seq_YYC3_Human	0.98988859
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98865081
95	RAC3_21632823_ChIP-Seq_H3396_Human	0.97976968
96	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.96796118
97	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.96457729
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.96457729
99	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.95367085
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94253845

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	7.30119790
2	MP0006292_abnormal_olfactory_placode	5.57912822
3	MP0005451_abnormal_body_composition	4.97643913
4	MP0000678_abnormal_parathyroid_gland	4.02965361
5	MP0002160_abnormal_reproductive_system	3.26132864
6	MP0003136_yellow_coat_color	3.15764924
7	MP0009379_abnormal_foot_pigmentation	3.03428530
8	MP0001666_abnormal_nutrient_absorption	2.82378457
9	MP0003183_abnormal_peptide_metabolism	2.64479850
10	MP0000427_abnormal_hair_cycle	2.60995639
11	MP0003950_abnormal_plasma_membrane	2.51956204
12	MP0009840_abnormal_foam_cell	2.46012842
13	MP0001485_abnormal_pinna_reflex	2.40210077
14	MP0006276_abnormal_autonomic_nervous	2.39784627
15	MP0003693_abnormal_embryo_hatching	2.39214260
16	MP0003938_abnormal_ear_development	2.38547763
17	MP0005360_urolithiasis	2.31086825
18	MP0004742_abnormal_vestibular_system	2.27383623
19	MP0005410_abnormal_fertilization	2.19521635
20	MP0001664_abnormal_digestion	1.98152817
21	MP0000049_abnormal_middle_ear	1.89908416
22	MP0003866_abnormal_defecation	1.87497309
23	MP0001873_stomach_inflammation	1.83521258
24	MP0001929_abnormal_gametogenesis	1.81331857
25	MP0005220_abnormal_exocrine_pancreas	1.77023145
26	MP0003119_abnormal_digestive_system	1.69664793
27	MP0005389_reproductive_system_phenotype	1.62352740
28	MP0005551_abnormal_eye_electrophysiolog	1.58445537
29	MP0001502_abnormal_circadian_rhythm	1.56419772
30	MP0006072_abnormal_retinal_apoptosis	1.51720202
31	MP0003763_abnormal_thymus_physiology	1.49541327
32	MP0003699_abnormal_female_reproductive	1.48671094
33	MP0010030_abnormal_orbit_morphology	1.47171684
34	MP0002210_abnormal_sex_determination	1.46354952
35	MP0010386_abnormal_urinary_bladder	1.45214265
36	MP0002249_abnormal_larynx_morphology	1.42461479
37	MP0005645_abnormal_hypothalamus_physiol	1.35978938
38	MP0002234_abnormal_pharynx_morphology	1.32592167
39	MP0002751_abnormal_autonomic_nervous	1.28512530
40	MP0005671_abnormal_response_to	1.26652732
41	MP0003890_abnormal_embryonic-extraembry	1.23818987
42	MP0000631_abnormal_neuroendocrine_gland	1.17394842
43	MP0003868_abnormal_feces_composition	1.17127435
44	MP0000470_abnormal_stomach_morphology	1.14726425
45	MP0003880_abnormal_central_pattern	1.13976734
46	MP0002184_abnormal_innervation	1.13615678
47	MP0002282_abnormal_trachea_morphology	1.13479980
48	MP0003698_abnormal_male_reproductive	1.11632365
49	MP0000467_abnormal_esophagus_morphology	1.09578232
50	MP0000653_abnormal_sex_gland	1.05475631
51	MP0005647_abnormal_sex_gland	1.02140060
52	MP0002161_abnormal_fertility/fecundity	0.99195967
53	MP0002229_neurodegeneration	0.98286869
54	MP0001501_abnormal_sleep_pattern	0.98261387
55	MP0005646_abnormal_pituitary_gland	0.98223759
56	MP0010094_abnormal_chromosome_stability	0.94485849
57	MP0000569_abnormal_digit_pigmentation	0.94419122
58	MP0001119_abnormal_female_reproductive	0.94308218
59	MP0000372_irregular_coat_pigmentation	0.94238069
60	MP0008058_abnormal_DNA_repair	0.93427824
61	MP0008875_abnormal_xenobiotic_pharmacok	0.84094973
62	MP0005623_abnormal_meninges_morphology	0.79028855
63	MP0000647_abnormal_sebaceous_gland	0.78612077
64	MP0001145_abnormal_male_reproductive	0.78159752
65	MP0002876_abnormal_thyroid_physiology	0.77871191
66	MP0001963_abnormal_hearing_physiology	0.77513209
67	MP0008872_abnormal_physiological_respon	0.76881153
68	MP0002163_abnormal_gland_morphology	0.76361241
69	MP0002272_abnormal_nervous_system	0.73324789
70	MP0008260_abnormal_autophagy	0.72877413
71	MP0009745_abnormal_behavioral_response	0.70418471
72	MP0003936_abnormal_reproductive_system	0.68848496
73	MP0000026_abnormal_inner_ear	0.68368902
74	MP0000230_abnormal_systemic_arterial	0.65774376
75	MP0001542_abnormal_bone_strength	0.64818619
76	MP0002102_abnormal_ear_morphology	0.64087220
77	MP0009115_abnormal_fat_cell	0.60943834
78	MP0001286_abnormal_eye_development	0.59188614
79	MP0001440_abnormal_grooming_behavior	0.58745267
80	MP0005253_abnormal_eye_physiology	0.58122854
81	MP0002693_abnormal_pancreas_physiology	0.57918935
82	MP0001486_abnormal_startle_reflex	0.57897653
83	MP0000762_abnormal_tongue_morphology	0.57139342
84	MP0005195_abnormal_posterior_eye	0.55536112
85	MP0002837_dystrophic_cardiac_calcinosis	0.55474663
86	MP0000778_abnormal_nervous_system	0.55187681
87	MP0008995_early_reproductive_senescence	0.54413352
88	MP0002067_abnormal_sensory_capabilities	0.54129852
89	MP0003879_abnormal_hair_cell	0.53282807
90	MP0004233_abnormal_muscle_weight	0.53223953
91	MP0009384_cardiac_valve_regurgitation	0.51857570
92	MP0001944_abnormal_pancreas_morphology	0.51805234
93	MP0004859_abnormal_synaptic_plasticity	0.50805955
94	MP0002752_abnormal_somatic_nervous	0.50366808
95	MP0002108_abnormal_muscle_morphology	0.50306767
96	MP0003718_maternal_effect	0.50175791
97	MP0002277_abnormal_respiratory_mucosa	0.48972414
98	MP0002736_abnormal_nociception_after	0.46594798
99	MP0009046_muscle_twitch	0.46216425
100	MP0002233_abnormal_nose_morphology	0.45830607

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	5.68310330
2	B lymphocytopenia (HP:0010976)	5.11624399
3	Abnormality of B cell number (HP:0010975)	4.53113139
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.39261523
5	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.29825446
6	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.29825446
7	Abnormal number of incisors (HP:0011064)	4.21847690
8	Median cleft lip (HP:0000161)	3.73021510
9	Abnormality of the corticospinal tract (HP:0002492)	3.59389302
10	Tetany (HP:0001281)	3.45220359
11	Short chin (HP:0000331)	3.41035779
12	Keratoconus (HP:0000563)	3.31749096
13	Increased corneal curvature (HP:0100692)	3.31749096
14	Facial cleft (HP:0002006)	3.28240781
15	Gastrointestinal infarctions (HP:0005244)	3.25946450
16	Oligodactyly (hands) (HP:0001180)	3.16670517
17	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.15350999
18	Retinal dysplasia (HP:0007973)	3.14419505
19	Short tibia (HP:0005736)	3.10967377
20	Decreased central vision (HP:0007663)	3.07247008
21	Chromsome breakage (HP:0040012)	2.99402671
22	Pendular nystagmus (HP:0012043)	2.97064460
23	Impulsivity (HP:0100710)	2.90790144
24	Pancreatic fibrosis (HP:0100732)	2.88584174
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.82004202
26	Abnormal auditory evoked potentials (HP:0006958)	2.81972937
27	Congenital sensorineural hearing impairment (HP:0008527)	2.80952692
28	Amelogenesis imperfecta (HP:0000705)	2.80022858
29	Microglossia (HP:0000171)	2.79526881
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.71901520
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71637792
32	Abnormality of alanine metabolism (HP:0010916)	2.71637792
33	Hyperalaninemia (HP:0003348)	2.71637792
34	Abolished electroretinogram (ERG) (HP:0000550)	2.68758300
35	Type I diabetes mellitus (HP:0100651)	2.61350525
36	Metaphyseal dysplasia (HP:0100255)	2.57980099
37	Hyperphosphatemia (HP:0002905)	2.56125041
38	Genital tract atresia (HP:0001827)	2.53913079
39	Anterior segment dysgenesis (HP:0007700)	2.52287798
40	Atonic seizures (HP:0010819)	2.49862826
41	Abnormality of the prostate (HP:0008775)	2.49493938
42	Medial flaring of the eyebrow (HP:0010747)	2.48966655
43	Autoimmune hemolytic anemia (HP:0001890)	2.48303565
44	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.46849624
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.42506211
46	Abnormality of chromosome stability (HP:0003220)	2.38877457
47	Attenuation of retinal blood vessels (HP:0007843)	2.36888664
48	Abnormality of the incisor (HP:0000676)	2.36640556
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.36538178
50	Diplopia (HP:0000651)	2.36371743
51	Abnormality of binocular vision (HP:0011514)	2.36371743
52	Submucous cleft hard palate (HP:0000176)	2.35700538
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35046419
54	Maternal diabetes (HP:0009800)	2.34602998
55	Abnormality of the nasal septum (HP:0000419)	2.33715905
56	Abnormality of the ileum (HP:0001549)	2.31378331
57	Anhidrosis (HP:0000970)	2.31125920
58	Increased IgM level (HP:0003496)	2.30593923
59	Adrenal hypoplasia (HP:0000835)	2.23305341
60	Ectopic kidney (HP:0000086)	2.21179089
61	Gastrointestinal atresia (HP:0002589)	2.20351929
62	Chronic bronchitis (HP:0004469)	2.20098562
63	Molar tooth sign on MRI (HP:0002419)	2.18719199
64	Abnormality of midbrain morphology (HP:0002418)	2.18719199
65	Lymphopenia (HP:0001888)	2.13828607
66	Partial agenesis of the corpus callosum (HP:0001338)	2.12551475
67	Acute myeloid leukemia (HP:0004808)	2.11431275
68	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.11407952
69	Congenital primary aphakia (HP:0007707)	2.11222249
70	Gait imbalance (HP:0002141)	2.08813148
71	Absent thumb (HP:0009777)	2.08099851
72	Abnormality of incisor morphology (HP:0011063)	2.07418478
73	Interstitial pulmonary disease (HP:0006530)	2.06324623
74	Autoimmune thrombocytopenia (HP:0001973)	2.04504115
75	Gaze-evoked nystagmus (HP:0000640)	2.03003934
76	Aortic dissection (HP:0002647)	2.00557122
77	Neurofibrillary tangles (HP:0002185)	2.00359510
78	Abnormality of dental color (HP:0011073)	2.00086357
79	Reticulocytopenia (HP:0001896)	1.99453210
80	Nephrogenic diabetes insipidus (HP:0009806)	1.96954440
81	Combined immunodeficiency (HP:0005387)	1.93806449
82	Meckel diverticulum (HP:0002245)	1.91770124
83	Clubbing of toes (HP:0100760)	1.89387142
84	Urinary bladder sphincter dysfunction (HP:0002839)	1.88470537
85	Vaginal atresia (HP:0000148)	1.87016019
86	Abnormality of the labia minora (HP:0012880)	1.86935837
87	Poor coordination (HP:0002370)	1.86058142
88	Abnormal ciliary motility (HP:0012262)	1.84041589
89	Short thumb (HP:0009778)	1.80592386
90	Abnormality of male internal genitalia (HP:0000022)	1.80298418
91	Multiple enchondromatosis (HP:0005701)	1.80265146
92	Oligodactyly (HP:0012165)	1.80233459
93	Abnormality of proline metabolism (HP:0010907)	1.78267833
94	Hydroxyprolinuria (HP:0003080)	1.78267833
95	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.76821183
96	Prolonged neonatal jaundice (HP:0006579)	1.76269213
97	IgG deficiency (HP:0004315)	1.75965214
98	Concave nail (HP:0001598)	1.74997389
99	Conical tooth (HP:0000698)	1.74551062
100	Pancytopenia (HP:0001876)	1.74045678

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.58115059
2	TAOK3	3.73715318
3	TEC	3.33081910
4	TNIK	3.11721143
5	ZAK	3.01759909
6	CDK8	2.78242004
7	PLK4	2.76109696
8	CDK12	2.56599123
9	AURKA	2.44301006
10	VRK1	2.21939038
11	NUAK1	2.20618226
12	STK39	2.14101880
13	PRKD3	2.04763945
14	EPHA4	1.97432541
15	CDK19	1.88658272
16	FRK	1.87743530
17	BMPR1B	1.81980209
18	MELK	1.81791511
19	ICK	1.78128028
20	TTK	1.59082177
21	TLK1	1.55493768
22	TRIM28	1.55104805
23	KDR	1.52634089
24	LATS1	1.46400944
25	ACVR1B	1.44813231
26	GRK1	1.32414460
27	NLK	1.28252347
28	MARK2	1.24322620
29	PKN1	1.22701666
30	ITK	1.17517131
31	PRKD2	1.14724166
32	TBK1	1.13156355
33	PIK3CG	1.03884590
34	CDC7	1.02646647
35	OXSR1	1.02089958
36	WNK1	0.99350427
37	MAP2K3	0.96730089
38	CDK4	0.94959299
39	MAP3K7	0.92729399
40	IRAK1	0.91528398
41	CDK9	0.91194614
42	CHEK2	0.90898729
43	LATS2	0.90449317
44	PIK3CA	0.90400232
45	PLK1	0.89088385
46	MAP3K3	0.85471791
47	GRK7	0.81491340
48	NME1	0.80063220
49	DMPK	0.78376365
50	SGK2	0.77881094
51	AURKB	0.73965386
52	STK38L	0.73644933
53	PRKCH	0.71457189
54	MAPK13	0.71236237
55	LIMK1	0.69403033
56	WNK4	0.67123320
57	CDK7	0.66748522
58	RPS6KA5	0.64700610
59	DYRK1B	0.64661290
60	ADRBK2	0.61507963
61	PBK	0.58970409
62	PRKACA	0.57540160
63	TESK2	0.55670626
64	PLK2	0.53671431
65	BTK	0.53507385
66	SRPK1	0.53395960
67	CAMK4	0.51951306
68	CSNK1D	0.48780145
69	STK3	0.46980906
70	MAP3K11	0.46598403
71	PIM2	0.45618444
72	MAPKAPK2	0.44776386
73	ILK	0.44605083
74	STK24	0.43932240
75	PRKACB	0.41573718
76	CSF1R	0.41248133
77	PAK1	0.40202720
78	PRKCA	0.40156916
79	NTRK2	0.37938392
80	JAK3	0.37132463
81	INSRR	0.36582721
82	NEK6	0.36433240
83	STK4	0.36113821
84	SGK3	0.36082206
85	MAP4K1	0.34706936
86	CDK2	0.34417106
87	PRKCE	0.33368135
88	GRK5	0.33198501
89	IGF1R	0.33022246
90	PRKCQ	0.32625908
91	SGK223	0.32496899
92	SGK494	0.32496899
93	GRK6	0.32315917
94	PIM1	0.32024910
95	PRKD1	0.31681181
96	CAMK1	0.31442561
97	PLK3	0.30809951
98	PRKAA1	0.30348949
99	CDK3	0.29538054
100	PRKG1	0.28415733

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	5.65323510
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.52215888
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.22366081
4	Mismatch repair_Homo sapiens_hsa03430	3.03508656
5	Homologous recombination_Homo sapiens_hsa03440	2.98021285
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.82003340
7	Ribosome_Homo sapiens_hsa03010	2.51203612
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39938790
9	Olfactory transduction_Homo sapiens_hsa04740	2.20407348
10	RNA polymerase_Homo sapiens_hsa03020	2.07968129
11	Bile secretion_Homo sapiens_hsa04976	2.05950333
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00804426
13	Phototransduction_Homo sapiens_hsa04744	1.97874193
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.96279634
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.84092944
16	RNA degradation_Homo sapiens_hsa03018	1.67745199
17	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.58202761
18	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.55841288
19	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.48687436
20	Sphingolipid metabolism_Homo sapiens_hsa00600	1.48140249
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30924579
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.29754145
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29708795
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.28904771
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.28758356
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28513389
27	Taste transduction_Homo sapiens_hsa04742	1.23862448
28	Insulin secretion_Homo sapiens_hsa04911	1.23850697
29	Retinol metabolism_Homo sapiens_hsa00830	1.21506539
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19466807
31	Alcoholism_Homo sapiens_hsa05034	1.12835609
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.12637208
33	Purine metabolism_Homo sapiens_hsa00230	1.08502090
34	Oocyte meiosis_Homo sapiens_hsa04114	1.07211745
35	Serotonergic synapse_Homo sapiens_hsa04726	1.05692242
36	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.04116472
37	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.02073058
38	Basal transcription factors_Homo sapiens_hsa03022	1.00128586
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.00035385
40	Colorectal cancer_Homo sapiens_hsa05210	0.95628734
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95183089
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93504942
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93356962
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90870789
45	DNA replication_Homo sapiens_hsa03030	0.85833448
46	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.85793750
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85748901
48	Cholinergic synapse_Homo sapiens_hsa04725	0.85490143
49	Protein export_Homo sapiens_hsa03060	0.84674981
50	Nicotine addiction_Homo sapiens_hsa05033	0.83382861
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74226741
52	Cocaine addiction_Homo sapiens_hsa05030	0.73113245
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70920069
54	Huntingtons disease_Homo sapiens_hsa05016	0.69865278
55	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69685942
56	GABAergic synapse_Homo sapiens_hsa04727	0.67735126
57	Sulfur metabolism_Homo sapiens_hsa00920	0.66632584
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64976335
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63604307
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58982648
61	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58044981
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57128326
63	Pancreatic secretion_Homo sapiens_hsa04972	0.56612160
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.55691147
65	Folate biosynthesis_Homo sapiens_hsa00790	0.54345008
66	Morphine addiction_Homo sapiens_hsa05032	0.53397811
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.53015271
68	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52189823
69	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.52131963
70	RNA transport_Homo sapiens_hsa03013	0.49817089
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48586306
72	Oxidative phosphorylation_Homo sapiens_hsa00190	0.47265671
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46145326
74	Parkinsons disease_Homo sapiens_hsa05012	0.45879315
75	Circadian entrainment_Homo sapiens_hsa04713	0.44214065
76	Regulation of autophagy_Homo sapiens_hsa04140	0.43671442
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43232022
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.40609823
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.39795084
80	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.38603880
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34139850
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34123765
83	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33045267
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.32967830
85	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.31819451
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.31334088
87	Butanoate metabolism_Homo sapiens_hsa00650	0.30154018
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29071335
89	Renin secretion_Homo sapiens_hsa04924	0.28776763
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.28264663
91	Measles_Homo sapiens_hsa05162	0.27780574
92	Circadian rhythm_Homo sapiens_hsa04710	0.25871607
93	One carbon pool by folate_Homo sapiens_hsa00670	0.24959937
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.24470732
95	Amphetamine addiction_Homo sapiens_hsa05031	0.23767945
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.21873945
97	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.21432809
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20424770
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19475241
100	Wnt signaling pathway_Homo sapiens_hsa04310	0.19227312

PRR23D2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »