ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand renaturation (GO:0000733)	9.07876148
2	cellular response to ATP (GO:0071318)	9.07773194
3	regulation of skeletal muscle contraction (GO:0014819)	8.05525626
4	negative regulation of cell aging (GO:0090344)	7.86536722
5	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	7.26130185
6	meiotic chromosome segregation (GO:0045132)	7.18633709
7	adenosine receptor signaling pathway (GO:0001973)	6.68044248
8	regulation of synapse structural plasticity (GO:0051823)	6.61804285
9	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	6.33822015
10	purinergic nucleotide receptor signaling pathway (GO:0035590)	5.99191892
11	lens fiber cell differentiation (GO:0070306)	5.60277319
12	rRNA methylation (GO:0031167)	5.59573613
13	mitotic cell cycle arrest (GO:0071850)	5.50343645
14	peptidyl-glutamic acid carboxylation (GO:0017187)	5.47704303
15	protein carboxylation (GO:0018214)	5.47704303
16	rRNA modification (GO:0000154)	5.11012953
17	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.10519338
18	response to ATP (GO:0033198)	5.09323231
19	positive regulation of protein kinase C signaling (GO:0090037)	4.89496628
20	sensory perception of taste (GO:0050909)	4.86869526
21	nucleotide-sugar biosynthetic process (GO:0009226)	4.64086453
22	positive regulation of megakaryocyte differentiation (GO:0045654)	4.60577202
23	nucleotide transmembrane transport (GO:1901679)	4.53563640
24	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	4.45142359
25	adenine nucleotide transport (GO:0051503)	4.42615833
26	mannose metabolic process (GO:0006013)	4.40237842
27	urinary tract smooth muscle contraction (GO:0014848)	4.34653363
28	regulation of interferon-beta biosynthetic process (GO:0045357)	4.32040688
29	purine ribonucleotide transport (GO:0015868)	4.31533128
30	purinergic receptor signaling pathway (GO:0035587)	4.30149365
31	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	4.11693770
32	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	4.08956710
33	melanin biosynthetic process (GO:0042438)	4.04000194
34	estrogen biosynthetic process (GO:0006703)	4.03480818
35	regulation of phospholipid biosynthetic process (GO:0071071)	4.01243754
36	sulfur amino acid catabolic process (GO:0000098)	3.99408745
37	positive regulation of systemic arterial blood pressure (GO:0003084)	3.95366661
38	endocytic recycling (GO:0032456)	3.94780882
39	DNA replication checkpoint (GO:0000076)	3.93097738
40	UV protection (GO:0009650)	3.90651450
41	transepithelial transport (GO:0070633)	3.88491968
42	negative regulation of interleukin-8 production (GO:0032717)	3.88336323
43	negative regulation of response to biotic stimulus (GO:0002832)	3.85222645
44	histone phosphorylation (GO:0016572)	3.79309353
45	mitochondrial genome maintenance (GO:0000002)	3.77533843
46	granulocyte differentiation (GO:0030851)	3.77165212
47	grooming behavior (GO:0007625)	3.74634516
48	positive regulation of heat generation (GO:0031652)	3.73978077
49	detection of light stimulus involved in sensory perception (GO:0050962)	3.73751551
50	detection of light stimulus involved in visual perception (GO:0050908)	3.73751551
51	peristalsis (GO:0030432)	3.71979959
52	melanin metabolic process (GO:0006582)	3.71622852
53	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.67271929
54	regulation of protein kinase A signaling (GO:0010738)	3.65821208
55	glutathione biosynthetic process (GO:0006750)	3.57266721
56	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.56740432
57	cornea development in camera-type eye (GO:0061303)	3.50810799
58	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.46252020
59	folic acid metabolic process (GO:0046655)	3.43174471
60	protein import into peroxisome matrix (GO:0016558)	3.42935916
61	nucleoside transmembrane transport (GO:1901642)	3.41944806
62	keratinocyte development (GO:0003334)	3.41914317
63	positive regulation of odontogenesis (GO:0042482)	3.33513602
64	sex determination (GO:0007530)	3.33060775
65	sphingomyelin metabolic process (GO:0006684)	3.32569156
66	purine nucleotide transport (GO:0015865)	3.29689693
67	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.20409167
68	nonribosomal peptide biosynthetic process (GO:0019184)	3.17411026
69	inositol phosphate dephosphorylation (GO:0046855)	3.11589395
70	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.11589395
71	regulation of cell aging (GO:0090342)	3.10627706
72	phosphatidylglycerol biosynthetic process (GO:0006655)	3.06817333
73	protein insertion into membrane (GO:0051205)	3.05624706
74	cellular anion homeostasis (GO:0030002)	3.03494419
75	secondary metabolite biosynthetic process (GO:0044550)	3.02258919
76	positive regulation of blood pressure (GO:0045777)	2.98522222
77	sialylation (GO:0097503)	2.95348021
78	phosphate ion homeostasis (GO:0055062)	2.90103728
79	trivalent inorganic anion homeostasis (GO:0072506)	2.90103728
80	proline biosynthetic process (GO:0006561)	2.87783329
81	negative regulation of actin filament bundle assembly (GO:0032232)	2.86991270
82	sphingosine metabolic process (GO:0006670)	2.83152471
83	regulation of urine volume (GO:0035809)	2.82785319
84	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.80011843
85	regulation of glycogen (starch) synthase activity (GO:2000465)	2.79130561
86	glycine transport (GO:0015816)	2.78934650
87	gonadal mesoderm development (GO:0007506)	2.78554034
88	tRNA modification (GO:0006400)	2.78250628
89	phosphate ion transmembrane transport (GO:0035435)	2.69730718
90	diol metabolic process (GO:0034311)	2.68791613
91	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.67136967
92	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.67136967
93	motile cilium assembly (GO:0044458)	2.67053085
94	behavioral response to nicotine (GO:0035095)	2.65817237
95	folic acid transport (GO:0015884)	2.65565859
96	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	2.65029698
97	cilium or flagellum-dependent cell motility (GO:0001539)	2.63073294
98	keratan sulfate metabolic process (GO:0042339)	2.62665109
99	regulation of heat generation (GO:0031650)	2.62032242
100	GDP-mannose metabolic process (GO:0019673)	10.4733476

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	4.70321291
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.22036498
3	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.54890787
4	* LXR_22292898_ChIP-Seq_THP-1_Human	2.99917437
5	P68_20966046_ChIP-Seq_HELA_Human	2.90681978
6	XRN2_22483619_ChIP-Seq_HELA_Human	2.63559833
7	VDR_24763502_ChIP-Seq_THP-1_Human	2.59111787
8	* MAF_26560356_Chip-Seq_TH2_Human	2.50348750
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.42899872
10	MAF_26560356_Chip-Seq_TH1_Human	2.40777375
11	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.28176461
12	BCOR_27268052_Chip-Seq_Bcells_Human	2.21565375
13	* RACK7_27058665_Chip-Seq_MCF-7_Human	2.19605624
14	E2F1_20622854_ChIP-Seq_HELA_Human	2.19511077
15	BCL6_27268052_Chip-Seq_Bcells_Human	2.15631216
16	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	2.14799489
17	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.11876040
18	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.10949823
19	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.10541882
20	CTCF_27219007_Chip-Seq_Bcells_Human	2.05730687
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.98563556
22	* UTX_26944678_Chip-Seq_JUKART_Human	1.97771604
23	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.96809958
24	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.96113288
25	PHF8_20622854_ChIP-Seq_HELA_Human	1.94806457
26	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.93801357
27	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.91115949
28	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.90666884
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.86240899
30	KDM2B_26808549_Chip-Seq_DND41_Human	1.82953397
31	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.82921265
32	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.82108231
33	MYC_22102868_ChIP-Seq_BL_Human	1.80317468
34	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.72957270
35	SMC4_20622854_ChIP-Seq_HELA_Human	1.72781100
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.72628376
37	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.69851824
38	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.69606721
39	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.67116885
40	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66767394
41	* CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.64953046
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.63868106
43	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.63122668
44	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.61741296
45	CTCF_21964334_Chip-Seq_Bcells_Human	1.59558908
46	TCF7_22412390_ChIP-Seq_EML_Mouse	1.55329746
47	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.54428457
48	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.52344246
49	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.51284829
50	* ELK3_25401928_ChIP-Seq_HUVEC_Human	1.50248769
51	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.48800598
52	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.47066604
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.44362493
54	TP53_22127205_ChIP-Seq_IMR90_Human	1.39412316
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.38952613
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.37474731
57	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.35927238
58	CTCF_20526341_ChIP-Seq_ESCs_Human	1.35252492
59	SA1_27219007_Chip-Seq_Bcells_Human	1.34971045
60	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33973961
61	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.27959148
62	* CIITA_25753668_ChIP-Seq_RAJI_Human	1.26704361
63	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.25069536
64	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.24398198
65	ERA_21632823_ChIP-Seq_H3396_Human	1.22274773
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.22029103
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.21943981
68	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.19864046
69	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.19446868
70	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19342107
71	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.19123560
72	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.19095763
73	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.18557508
74	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.18554526
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17902139
76	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.15194114
77	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.14214254
78	NCOR1_26117541_ChIP-Seq_K562_Human	1.14056346
79	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.12890952
80	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.11838367
81	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.11817208
82	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.11437563
83	* ATF3_27146783_Chip-Seq_COLON_Human	1.10287481
84	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.08770519
85	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.08365074
86	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.05954591
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.05030904
88	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.03970919
89	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.03396282
90	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.03051768
91	P300_27268052_Chip-Seq_Bcells_Human	1.03030604
92	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.02747931
93	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02137770
94	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.01233437
95	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.96417000
96	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.96181643
97	SPI1_20517297_ChIP-Seq_HL60_Human	0.95844749
98	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.95569716
99	* KDM2B_26808549_Chip-Seq_K562_Human	0.94902206
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.94860834

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	7.30182431
2	MP0001986_abnormal_taste_sensitivity	5.93593573
3	MP0005423_abnormal_somatic_nervous	5.69828947
4	MP0005174_abnormal_tail_pigmentation	5.59529509
5	MP0003136_yellow_coat_color	4.78986232
6	MP0005409_darkened_coat_color	3.20736067
7	MP0005083_abnormal_biliary_tract	3.06834411
8	MP0004381_abnormal_hair_follicle	2.98225395
9	MP0001188_hyperpigmentation	2.70925751
10	MP0001968_abnormal_touch/_nociception	2.66012785
11	MP0001756_abnormal_urination	2.12112493
12	MP0004130_abnormal_muscle_cell	2.09641753
13	MP0000015_abnormal_ear_pigmentation	2.02157098
14	MP0002736_abnormal_nociception_after	1.89765738
15	MP0001661_extended_life_span	1.88617525
16	MP0008875_abnormal_xenobiotic_pharmacok	1.85628249
17	MP0000751_myopathy	1.81579312
18	MP0003705_abnormal_hypodermis_morpholog	1.78234685
19	MP0003453_abnormal_keratinocyte_physiol	1.76064459
20	MP0001502_abnormal_circadian_rhythm	1.66981554
21	MP0003111_abnormal_nucleus_morphology	1.59259323
22	MP0000538_abnormal_urinary_bladder	1.57888683
23	MP0005330_cardiomyopathy	1.54996622
24	MP0005257_abnormal_intraocular_pressure	1.54117599
25	MP0001348_abnormal_lacrimal_gland	1.53539079
26	MP0002160_abnormal_reproductive_system	1.50642074
27	MP0005076_abnormal_cell_differentiation	1.47124161
28	MP0000750_abnormal_muscle_regeneration	1.45790630
29	MP0003303_peritoneal_inflammation	1.44767592
30	MP0002909_abnormal_adrenal_gland	1.41420808
31	MP0002638_abnormal_pupillary_reflex	1.35892918
32	MP0003878_abnormal_ear_physiology	1.29411510
33	MP0005377_hearing/vestibular/ear_phenot	1.29411510
34	MP0005058_abnormal_lysosome_morphology	1.20481741
35	MP0003011_delayed_dark_adaptation	1.19839595
36	MP0003448_altered_tumor_morphology	1.17396280
37	MP0009840_abnormal_foam_cell	1.12016128
38	MP0005410_abnormal_fertilization	1.11470726
39	MP0003693_abnormal_embryo_hatching	1.08551326
40	MP0003137_abnormal_impulse_conducting	1.08525663
41	MP0005332_abnormal_amino_acid	1.07735373
42	MP0009278_abnormal_bone_marrow	1.05401671
43	MP0005084_abnormal_gallbladder_morpholo	1.05346390
44	MP0001765_abnormal_ion_homeostasis	1.05213403
45	MP0009333_abnormal_splenocyte_physiolog	1.02489641
46	MP0005501_abnormal_skin_physiology	1.01314003
47	MP0001919_abnormal_reproductive_system	1.00320546
48	MP0002735_abnormal_chemical_nociception	0.99346347
49	MP0005551_abnormal_eye_electrophysiolog	0.98325372
50	MP0005584_abnormal_enzyme/coenzyme_acti	0.96593863
51	MP0001664_abnormal_digestion	0.95323671
52	MP0004043_abnormal_pH_regulation	0.95004670
53	MP0005220_abnormal_exocrine_pancreas	0.93939141
54	MP0000003_abnormal_adipose_tissue	0.90358899
55	MP0000013_abnormal_adipose_tissue	0.89997634
56	MP0000470_abnormal_stomach_morphology	0.89814211
57	MP0000367_abnormal_coat/_hair	0.84790056
58	MP0002075_abnormal_coat/hair_pigmentati	0.83217783
59	MP0003183_abnormal_peptide_metabolism	0.80741565
60	MP0003806_abnormal_nucleotide_metabolis	0.79151007
61	MP0009931_abnormal_skin_appearance	0.78749555
62	MP0003077_abnormal_cell_cycle	0.78687873
63	MP0004185_abnormal_adipocyte_glucose	0.78627912
64	MP0002928_abnormal_bile_duct	0.78257764
65	MP0001905_abnormal_dopamine_level	0.78068656
66	MP0001958_emphysema	0.76406378
67	MP0004019_abnormal_vitamin_homeostasis	0.74555597
68	MP0001324_abnormal_eye_pigmentation	0.71383911
69	MP0004957_abnormal_blastocyst_morpholog	0.70563308
70	MP0000371_diluted_coat_color	0.70451283
71	MP0000747_muscle_weakness	0.67358147
72	MP0003091_abnormal_cell_migration	0.66918882
73	MP0002136_abnormal_kidney_physiology	0.66881619
74	MP0002019_abnormal_tumor_incidence	0.66482969
75	MP0001849_ear_inflammation	0.63203752
76	MP0009643_abnormal_urine_homeostasis	0.61806219
77	MP0010771_integument_phenotype	0.60614596
78	MP0005253_abnormal_eye_physiology	0.60500451
79	MP0004947_skin_inflammation	0.57889517
80	MP0002723_abnormal_immune_serum	0.57806200
81	MP0005365_abnormal_bile_salt	0.55722002
82	MP0005389_reproductive_system_phenotype	0.55566135
83	MP0001346_abnormal_lacrimal_gland	0.54623516
84	MP0005025_abnormal_response_to	0.54546660
85	MP0002933_joint_inflammation	0.53716320
86	MP0001873_stomach_inflammation	0.53017804
87	MP0002398_abnormal_bone_marrow	0.52331402
88	MP0002148_abnormal_hypersensitivity_rea	0.51503532
89	MP0001800_abnormal_humoral_immune	0.51278938
90	MP0000678_abnormal_parathyroid_gland	0.51167738
91	MP0001191_abnormal_skin_condition	0.50728994
92	MP0001835_abnormal_antigen_presentation	0.49914151
93	MP0002429_abnormal_blood_cell	0.49657922
94	MP0002452_abnormal_antigen_presenting	0.47372016
95	MP0005647_abnormal_sex_gland	0.46661352
96	MP0001186_pigmentation_phenotype	0.46534904
97	MP0002420_abnormal_adaptive_immunity	0.44985820
98	MP0010094_abnormal_chromosome_stability	0.44646056
99	MP0003045_fibrosis	0.44040097
100	MP0003879_abnormal_hair_cell	0.43717122

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	6.28889289
2	Rectal fistula (HP:0100590)	6.01884955
3	Rectovaginal fistula (HP:0000143)	6.01884955
4	Rib fusion (HP:0000902)	5.87239121
5	Intestinal fistula (HP:0100819)	5.71166705
6	Vaginal fistula (HP:0004320)	5.50345596
7	Poikiloderma (HP:0001029)	4.94089962
8	Attenuation of retinal blood vessels (HP:0007843)	4.64279999
9	Thin bony cortex (HP:0002753)	4.51649551
10	Congenital stationary night blindness (HP:0007642)	4.46309536
11	Ulnar bowing (HP:0003031)	4.34946303
12	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.27577580
13	Dyschromatopsia (HP:0007641)	4.26859765
14	Akinesia (HP:0002304)	4.20492236
15	Popliteal pterygium (HP:0009756)	4.09878399
16	Abnormality of the intrinsic pathway (HP:0010989)	4.09177557
17	Annular pancreas (HP:0001734)	4.04029105
18	Facial diplegia (HP:0001349)	3.81369325
19	Facial hemangioma (HP:0000329)	3.77314347
20	Chorioretinal atrophy (HP:0000533)	3.63374075
21	Squamous cell carcinoma (HP:0002860)	3.57216665
22	Aplasia of the musculature (HP:0100854)	3.54167051
23	Mesangial abnormality (HP:0001966)	3.52998672
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.52507270
25	Joint hemorrhage (HP:0005261)	3.50404994
26	Turricephaly (HP:0000262)	3.50212101
27	Prolonged partial thromboplastin time (HP:0003645)	3.49564346
28	Fetal akinesia sequence (HP:0001989)	3.44112547
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.42310782
30	Hypoalbuminemia (HP:0003073)	3.38953406
31	Abnormal albumin level (HP:0012116)	3.38953406
32	Premature graying of hair (HP:0002216)	3.34094564
33	Atrioventricular block (HP:0001678)	3.33745195
34	Short chin (HP:0000331)	3.30993539
35	Delayed epiphyseal ossification (HP:0002663)	3.28061418
36	Anteriorly placed anus (HP:0001545)	3.21502985
37	Hemorrhage of the eye (HP:0011885)	3.16594283
38	Coronal craniosynostosis (HP:0004440)	3.13461367
39	Choroideremia (HP:0001139)	3.03223517
40	Bony spicule pigmentary retinopathy (HP:0007737)	2.94173592
41	Amniotic constriction ring (HP:0009775)	2.91669684
42	Abnormality of placental membranes (HP:0011409)	2.91669684
43	Fused cervical vertebrae (HP:0002949)	2.89712507
44	Patellar aplasia (HP:0006443)	2.87822211
45	Decreased central vision (HP:0007663)	2.84068036
46	Abnormality of the costochondral junction (HP:0000919)	2.81967575
47	Aplasia/Hypoplasia of the patella (HP:0006498)	2.68099421
48	Increased hepatocellular lipid droplets (HP:0006565)	2.67550083
49	Renal Fanconi syndrome (HP:0001994)	2.67041672
50	Birth length less than 3rd percentile (HP:0003561)	2.61380987
51	Abnormality of the pons (HP:0007361)	2.59941719
52	Enlarged epiphyses (HP:0010580)	2.52734744
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.51074141
54	Hypoplasia of the pons (HP:0012110)	2.50753342
55	Joint stiffness (HP:0001387)	2.46585222
56	Lipid accumulation in hepatocytes (HP:0006561)	2.45063563
57	Bowing of the arm (HP:0006488)	2.42869045
58	Bowed forearm bones (HP:0003956)	2.42869045
59	Myotonia (HP:0002486)	2.39844627
60	Myopathic facies (HP:0002058)	2.37840005
61	Absent thumb (HP:0009777)	2.35792746
62	Widely patent fontanelles and sutures (HP:0004492)	2.32425694
63	Pustule (HP:0200039)	2.32081096
64	Zonular cataract (HP:0010920)	2.29726931
65	Reduced antithrombin III activity (HP:0001976)	2.22893926
66	Flat occiput (HP:0005469)	2.22731499
67	Unilateral renal agenesis (HP:0000122)	2.13842190
68	Cheilitis (HP:0100825)	2.09316041
69	Increased number of teeth (HP:0011069)	2.09007192
70	Abnormal epiphyseal ossification (HP:0010656)	2.08658943
71	Gastrointestinal infarctions (HP:0005244)	2.04541227
72	Basal cell carcinoma (HP:0002671)	2.04066855
73	Choanal stenosis (HP:0000452)	2.03081194
74	Short thumb (HP:0009778)	2.02267404
75	Thrombocytosis (HP:0001894)	2.02126790
76	Hypophosphatemic rickets (HP:0004912)	2.01646797
77	Short humerus (HP:0005792)	2.00654198
78	Capillary hemangiomas (HP:0005306)	1.97519551
79	Neonatal onset (HP:0003623)	1.96169621
80	Progressive external ophthalmoplegia (HP:0000590)	1.96109439
81	Exertional dyspnea (HP:0002875)	1.94347524
82	Increased intramyocellular lipid droplets (HP:0012240)	1.93505626
83	Male infertility (HP:0003251)	1.92372902
84	Narrow nasal bridge (HP:0000446)	1.91234706
85	Thin ribs (HP:0000883)	1.89606428
86	Abnormality of small intestinal villus morphology (HP:0011472)	1.88365459
87	Villous atrophy (HP:0011473)	1.88365459
88	Heart block (HP:0012722)	1.85466738
89	Absent radius (HP:0003974)	1.85160803
90	Decreased circulating renin level (HP:0003351)	1.84980370
91	Increased muscle lipid content (HP:0009058)	1.84748303
92	Abnormality of polysaccharide metabolism (HP:0011012)	1.84726467
93	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.84726467
94	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.84726467
95	Abnormality of the common coagulation pathway (HP:0010990)	1.83886090
96	Abnormal trabecular bone morphology (HP:0100671)	1.83038321
97	Urinary glycosaminoglycan excretion (HP:0003541)	1.81844947
98	Mucopolysacchariduria (HP:0008155)	1.81844947
99	Diminished movement (HP:0002374)	1.80752172
100	Neonatal respiratory distress (HP:0002643)	1.80313604

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	6.95314242
2	BLK	4.91947925
3	TLK1	4.42923741
4	WNK4	3.74065524
5	TESK2	3.24240985
6	GRK6	2.82710857
7	SIK2	2.81342539
8	PDK2	2.65805558
9	MUSK	2.58099383
10	ZAK	2.54294437
11	STK16	2.50065316
12	ADRBK2	2.11464686
13	TAOK3	2.01810049
14	TRIB3	1.76810507
15	MAP4K1	1.74857386
16	SIK1	1.73969524
17	ZAP70	1.60752298
18	GRK7	1.60362278
19	TBK1	1.49305216
20	IRAK2	1.43977812
21	SMG1	1.39106286
22	IKBKE	1.34627258
23	IRAK4	1.31884798
24	CCNB1	1.25139237
25	MAPK12	1.23928762
26	ERN1	1.22764242
27	NEK2	1.22302772
28	MAP2K3	1.18157025
29	MAP2K4	1.15225591
30	WNK1	1.04349057
31	PDPK1	1.03861507
32	SYK	1.02761818
33	ADRBK1	1.02173652
34	HIPK2	1.01270046
35	KDR	1.00551869
36	RPS6KA6	0.93190421
37	IKBKB	0.93122850
38	CSK	0.90623465
39	CDK4	0.89216370
40	PIM1	0.86955999
41	PRKD2	0.85457644
42	RPS6KC1	0.84332435
43	RPS6KL1	0.84332435
44	STK39	0.79263549
45	AURKA	0.77044262
46	MST1R	0.74769833
47	RIPK4	0.73362936
48	STK11	0.73355696
49	LYN	0.73090915
50	PRKD1	0.72473386
51	FES	0.70091874
52	PIM2	0.70071035
53	MAPK11	0.69286835
54	EEF2K	0.67048181
55	STK4	0.64673027
56	RPS6KA2	0.61995932
57	MAP2K6	0.61592437
58	MAP3K2	0.61331090
59	SIK3	0.61241020
60	RPS6KA5	0.54069580
61	DYRK1B	0.51851133
62	GRK5	0.50298947
63	MAP3K14	0.50033883
64	JAK3	0.49674491
65	DAPK2	0.49483077
66	CDK15	0.48509341
67	SGK223	0.48454470
68	SGK494	0.48454470
69	BTK	0.46237042
70	ACVR1B	0.45770620
71	PDK1	0.44206421
72	CDK18	0.43014038
73	CDK6	0.40632208
74	CDK11A	0.39197069
75	DAPK3	0.38909517
76	JAK2	0.37512290
77	PAK1	0.36758972
78	CSF1R	0.33816109
79	PRPF4B	0.33091358
80	KSR2	0.32380562
81	CHEK2	0.32353938
82	ATR	0.30226317
83	MAPK7	0.28591085
84	MELK	0.28168931
85	PDGFRB	0.27497962
86	CHUK	0.27037675
87	VRK1	0.26305876
88	MAPK8	0.23730357
89	RAF1	0.23543808
90	TGFBR2	0.22663414
91	BMX	0.21433732
92	AKT2	0.20861443
93	STK10	0.20793718
94	SGK3	0.20527673
95	MAP2K1	0.20009468
96	CDK8	0.18541851
97	MAPKAPK3	0.17197494
98	PRKG2	0.16391089
99	CDK14	0.16323553
100	TNK2	0.15225817

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	7.46895014
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	5.65563864
3	Sulfur relay system_Homo sapiens_hsa04122	4.79474712
4	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.55831971
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.44560796
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.16435572
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.65147076
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.02084196
9	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.79105591
10	Sphingolipid metabolism_Homo sapiens_hsa00600	1.55074750
11	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.52923798
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46111764
13	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.43728412
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.41649885
15	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.39889413
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35994893
17	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.33740076
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28483672
19	Alcoholism_Homo sapiens_hsa05034	1.19519531
20	Taste transduction_Homo sapiens_hsa04742	1.14070738
21	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.12963504
22	mTOR signaling pathway_Homo sapiens_hsa04150	1.12809133
23	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.12372804
24	Bladder cancer_Homo sapiens_hsa05219	1.10595075
25	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10544550
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.09964064
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.07868898
28	Circadian rhythm_Homo sapiens_hsa04710	0.93833516
29	Lysosome_Homo sapiens_hsa04142	0.90906018
30	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.86179649
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.84010267
32	Nitrogen metabolism_Homo sapiens_hsa00910	0.83728216
33	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.81485245
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81270546
35	Other glycan degradation_Homo sapiens_hsa00511	0.81198981
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.79010393
37	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.78872449
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.68692831
39	Phototransduction_Homo sapiens_hsa04744	0.64625355
40	Leishmaniasis_Homo sapiens_hsa05140	0.62234157
41	VEGF signaling pathway_Homo sapiens_hsa04370	0.61084779
42	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.60574127
43	Tuberculosis_Homo sapiens_hsa05152	0.57634355
44	Melanogenesis_Homo sapiens_hsa04916	0.57180460
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56303152
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.56097262
47	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.56078649
48	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.54850963
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.54705654
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52752139
51	Non-small cell lung cancer_Homo sapiens_hsa05223	0.51905403
52	Endocytosis_Homo sapiens_hsa04144	0.51046480
53	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.50297093
54	Osteoclast differentiation_Homo sapiens_hsa04380	0.49739473
55	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.47053301
56	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43864061
57	Insulin resistance_Homo sapiens_hsa04931	0.42622665
58	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40585788
59	RNA polymerase_Homo sapiens_hsa03020	0.40128973
60	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.39804956
61	Cocaine addiction_Homo sapiens_hsa05030	0.39758344
62	Influenza A_Homo sapiens_hsa05164	0.38428750
63	Toxoplasmosis_Homo sapiens_hsa05145	0.38424539
64	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.37705850
65	Platelet activation_Homo sapiens_hsa04611	0.36619820
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.35388890
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35193579
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.34717949
69	Bile secretion_Homo sapiens_hsa04976	0.34480411
70	Gap junction_Homo sapiens_hsa04540	0.33629441
71	Apoptosis_Homo sapiens_hsa04210	0.33175559
72	HTLV-I infection_Homo sapiens_hsa05166	0.32457010
73	Hippo signaling pathway_Homo sapiens_hsa04390	0.32368131
74	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.32063717
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31716934
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31558027
77	Viral carcinogenesis_Homo sapiens_hsa05203	0.29579155
78	Measles_Homo sapiens_hsa05162	0.28296871
79	Hepatitis C_Homo sapiens_hsa05160	0.27584068
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26662798
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.26102827
82	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.25635111
83	Base excision repair_Homo sapiens_hsa03410	0.25489406
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.25453896
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.25262694
86	Basal transcription factors_Homo sapiens_hsa03022	0.25073653
87	Nicotine addiction_Homo sapiens_hsa05033	0.24960703
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.23998144
89	MAPK signaling pathway_Homo sapiens_hsa04010	0.22913707
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22102054
91	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.21055928
92	Chemokine signaling pathway_Homo sapiens_hsa04062	0.19602853
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18236025
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.17874368
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.16587125
96	TNF signaling pathway_Homo sapiens_hsa04668	0.15442037
97	Sulfur metabolism_Homo sapiens_hsa00920	0.15057436
98	Cholinergic synapse_Homo sapiens_hsa04725	0.14891063
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.14387356
100	Graft-versus-host disease_Homo sapiens_hsa05332	0.12608194

PRR25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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