PRR27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.53177745
2spermatid development (GO:0007286)9.51050470
3regulation of cilium movement (GO:0003352)9.39473660
4motile cilium assembly (GO:0044458)9.16028242
5cilium movement (GO:0003341)9.15781488
6sperm capacitation (GO:0048240)8.29048662
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.24404720
8piRNA metabolic process (GO:0034587)8.03687711
9single fertilization (GO:0007338)7.81515382
10male meiosis (GO:0007140)7.65541797
11synaptonemal complex organization (GO:0070193)7.09648130
12synaptonemal complex assembly (GO:0007130)6.84409618
13fertilization (GO:0009566)6.54926489
14organic cation transport (GO:0015695)6.23304899
15negative regulation of inclusion body assembly (GO:0090084)6.18550770
16spermatogenesis (GO:0007283)6.13352780
17male gamete generation (GO:0048232)6.11119613
18ventricular system development (GO:0021591)6.02132317
19microtubule depolymerization (GO:0007019)5.81095293
20regulation of microtubule-based movement (GO:0060632)5.80511870
21gamete generation (GO:0007276)5.61890457
22cellular process involved in reproduction in multicellular organism (GO:0022412)5.42254248
23male meiosis I (GO:0007141)5.39377799
24germ cell development (GO:0007281)5.34861875
25regulation of inclusion body assembly (GO:0090083)5.19720254
26calcium ion-dependent exocytosis (GO:0017156)5.10078178
27behavioral response to nicotine (GO:0035095)5.08896134
28microtubule severing (GO:0051013)4.92432577
29cell recognition (GO:0008037)4.92070529
30chromosome organization involved in meiosis (GO:0070192)4.85568934
31DNA methylation involved in gamete generation (GO:0043046)4.81553832
32left/right pattern formation (GO:0060972)4.70373322
33meiotic nuclear division (GO:0007126)4.51038464
34multicellular organismal reproductive process (GO:0048609)4.47612943
35seminiferous tubule development (GO:0072520)4.34840718
36meiosis I (GO:0007127)4.28328951
37gamma-aminobutyric acid transport (GO:0015812)4.05964327
38protein polyglutamylation (GO:0018095)4.01777509
39monoubiquitinated protein deubiquitination (GO:0035520)4.00035751
40glycerol ether metabolic process (GO:0006662)3.98943208
41protein localization to cilium (GO:0061512)3.93879428
42genitalia morphogenesis (GO:0035112)3.92011988
43response to pheromone (GO:0019236)3.76677792
44detection of light stimulus involved in sensory perception (GO:0050962)3.73678370
45detection of light stimulus involved in visual perception (GO:0050908)3.73678370
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.73358214
47spermatid nucleus differentiation (GO:0007289)3.72524858
48platelet dense granule organization (GO:0060155)3.72246371
49ether metabolic process (GO:0018904)3.67652935
50meiotic cell cycle (GO:0051321)3.65598097
51cellular ketone body metabolic process (GO:0046950)3.63793502
52protein-cofactor linkage (GO:0018065)3.59258845
53multicellular organismal development (GO:0007275)3.57071830
54kidney morphogenesis (GO:0060993)3.56278457
55neuronal action potential propagation (GO:0019227)3.55012210
56regulation of neurotransmitter uptake (GO:0051580)3.49821467
57tryptophan catabolic process (GO:0006569)3.48377464
58indole-containing compound catabolic process (GO:0042436)3.48377464
59indolalkylamine catabolic process (GO:0046218)3.48377464
60chaperone-mediated protein complex assembly (GO:0051131)3.42689623
61negative regulation of organelle assembly (GO:1902116)3.42321588
62water-soluble vitamin biosynthetic process (GO:0042364)3.41148108
63chromosome condensation (GO:0030261)3.40685508
64DNA packaging (GO:0006323)3.27768287
65sulfation (GO:0051923)3.27184704
66ketone body metabolic process (GO:1902224)3.26734950
67fucose catabolic process (GO:0019317)3.25799101
68L-fucose metabolic process (GO:0042354)3.25799101
69L-fucose catabolic process (GO:0042355)3.25799101
70neuronal action potential (GO:0019228)3.23339508
71microtubule-based movement (GO:0007018)3.22977941
72carnitine transport (GO:0015879)3.22267980
73amino-acid betaine transport (GO:0015838)3.22267980
74DNA deamination (GO:0045006)3.21563887
75protein refolding (GO:0042026)3.18095823
76intraciliary transport (GO:0042073)3.17587218
77negative regulation of mast cell activation (GO:0033004)3.16075231
78carnitine transmembrane transport (GO:1902603)3.08434672
79indolalkylamine metabolic process (GO:0006586)3.08144310
80glycolytic process (GO:0006096)3.07387270
81cilium organization (GO:0044782)3.05053621
82regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.04925795
83regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.04925795
84energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02907670
85ATP synthesis coupled proton transport (GO:0015986)3.02907670
86nonmotile primary cilium assembly (GO:0035058)3.01312835
87gene silencing by RNA (GO:0031047)3.00861702
88kynurenine metabolic process (GO:0070189)3.00521664
89inner ear receptor stereocilium organization (GO:0060122)2.98740897
90axoneme assembly (GO:0035082)2.98694870
91microtubule polymerization or depolymerization (GO:0031109)2.98646164
92neural tube formation (GO:0001841)2.94346774
93tryptophan metabolic process (GO:0006568)2.93525716
94regulation of spindle checkpoint (GO:0090231)2.92727685
95regulation of centriole replication (GO:0046599)2.92657973
96cilium assembly (GO:0042384)2.92086060
97nucleoside diphosphate phosphorylation (GO:0006165)2.91182437
98behavioral response to ethanol (GO:0048149)2.90883054
99peptidyl-glutamic acid modification (GO:0018200)2.90762068
100lactate metabolic process (GO:0006089)2.90648363
101nuclear pore complex assembly (GO:0051292)2.90067492
102alditol metabolic process (GO:0019400)2.89908339
103protein complex biogenesis (GO:0070271)2.89883256
104meiotic cell cycle process (GO:1903046)2.87881654
105somite development (GO:0061053)2.86509135
106polyol catabolic process (GO:0046174)2.84864629
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82975958
108regulation of action potential (GO:0098900)2.79458851
109cellular component assembly involved in morphogenesis (GO:0010927)2.79118762
110amine catabolic process (GO:0009310)2.78730372
111cellular biogenic amine catabolic process (GO:0042402)2.78730372
112prostate gland growth (GO:0060736)2.77882026
113cornea development in camera-type eye (GO:0061303)2.77751381
114negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77732983
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77511632
116adult feeding behavior (GO:0008343)2.77157592
117single strand break repair (GO:0000012)2.77041233
118nephron epithelium morphogenesis (GO:0072088)2.77016036
119nephron tubule morphogenesis (GO:0072078)2.77016036
120respiratory chain complex IV assembly (GO:0008535)2.76798247
121primary amino compound metabolic process (GO:1901160)2.76610404
122nucleus organization (GO:0006997)2.76571247
123synaptic transmission, cholinergic (GO:0007271)2.75607282
124negative regulation of telomere maintenance (GO:0032205)2.74680640
125photoreceptor cell maintenance (GO:0045494)2.73429084
126synapsis (GO:0007129)2.73113526
127protein K11-linked deubiquitination (GO:0035871)2.73056983
128cilium morphogenesis (GO:0060271)2.72888952
129indole-containing compound metabolic process (GO:0042430)2.71258794
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.70312554
131NADH dehydrogenase complex assembly (GO:0010257)2.70312554
132mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70312554
133auditory receptor cell stereocilium organization (GO:0060088)2.68705884
134regulation of acrosome reaction (GO:0060046)2.68264309
135phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63310844
136postsynaptic membrane organization (GO:0001941)2.63221526
137negative regulation of skeletal muscle tissue development (GO:0048642)2.62266031
138dopamine transport (GO:0015872)2.61976308
139aromatic amino acid family catabolic process (GO:0009074)2.61883357
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.60828572
141mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60495583
142regulation of meiosis I (GO:0060631)2.60460388
143RNA localization (GO:0006403)2.59563382
144retinal ganglion cell axon guidance (GO:0031290)2.58844827
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.57991044
146purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.57991044
147regulation of protein kinase A signaling (GO:0010738)2.56675407
148mitochondrial respiratory chain complex assembly (GO:0033108)2.56464555
149centriole assembly (GO:0098534)2.54380437
150peristalsis (GO:0030432)2.53938464
151regulation of cilium assembly (GO:1902017)2.52151485
152spinal cord motor neuron differentiation (GO:0021522)2.51087129
153positive regulation of mitochondrial fission (GO:0090141)2.50937907
154mitotic sister chromatid cohesion (GO:0007064)2.49863256
155dendritic spine morphogenesis (GO:0060997)2.49061528
156sexual reproduction (GO:0019953)2.48971422
157ubiquinone biosynthetic process (GO:0006744)2.48678713
158regulation of protein kinase C signaling (GO:0090036)2.47998956
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46899051
160photoreceptor cell development (GO:0042461)2.46397019
161ovulation cycle (GO:0042698)2.45918056
162sex differentiation (GO:0007548)2.44851077
163reflex (GO:0060004)2.44400990
164serotonin metabolic process (GO:0042428)2.43086327
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.42929484
166keratinocyte development (GO:0003334)2.42365539
167phosphatidylserine acyl-chain remodeling (GO:0036150)2.41739891
168cytochrome complex assembly (GO:0017004)2.40939390
169rhodopsin mediated signaling pathway (GO:0016056)2.40248950
170detection of mechanical stimulus involved in sensory perception (GO:0050974)2.40203375
171positive regulation of meiosis (GO:0045836)2.39799034
172regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.38850063
173substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.37687441
174fusion of sperm to egg plasma membrane (GO:0007342)14.5819707
175sperm motility (GO:0030317)13.8128357
176cilium or flagellum-dependent cell motility (GO:0001539)13.0246324
177multicellular organism reproduction (GO:0032504)11.5437955
178sperm-egg recognition (GO:0035036)11.4501569
179acrosome reaction (GO:0007340)11.3178527
180plasma membrane fusion (GO:0045026)11.1367731
181epithelial cilium movement (GO:0003351)10.7560654
182cell wall macromolecule metabolic process (GO:0044036)10.7480551
183cell wall macromolecule catabolic process (GO:0016998)10.7480551
184acrosome assembly (GO:0001675)10.6233010
185axonemal dynein complex assembly (GO:0070286)10.5960082
186binding of sperm to zona pellucida (GO:0007339)10.2685981
187cell-cell recognition (GO:0009988)10.2438127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.25108545
2EZH2_22144423_ChIP-Seq_EOC_Human4.79130915
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63235990
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18744477
5GBX2_23144817_ChIP-Seq_PC3_Human2.96333258
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70945961
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50873681
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38731526
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32419964
10VDR_22108803_ChIP-Seq_LS180_Human2.32303738
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20718886
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18996793
13EWS_26573619_Chip-Seq_HEK293_Human2.14466912
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02795263
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02431009
16IGF1R_20145208_ChIP-Seq_DFB_Human2.00605473
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.96409800
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96398208
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95516364
20FUS_26573619_Chip-Seq_HEK293_Human1.91475768
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89029349
22P300_19829295_ChIP-Seq_ESCs_Human1.88672018
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86338280
24ZNF274_21170338_ChIP-Seq_K562_Hela1.85947365
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84358176
26STAT1_17558387_ChIP-Seq_HELA_Human1.82123360
27ER_23166858_ChIP-Seq_MCF-7_Human1.76023291
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74115763
29WDR5_24793694_ChIP-Seq_LNCAP_Human1.72637495
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69332199
31CBP_20019798_ChIP-Seq_JUKART_Human1.68989782
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68989782
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68462713
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68237834
35KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66592877
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.65147315
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62262025
38FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60852409
39AR_25329375_ChIP-Seq_VCAP_Human1.59978170
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56976808
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56432546
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50228664
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.50044296
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49148795
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49033610
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47348071
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46653020
48IRF1_19129219_ChIP-ChIP_H3396_Human1.43942353
49KDM2B_26808549_Chip-Seq_REH_Human1.43376272
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42752056
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42226976
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.42193716
53SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42059075
54SMAD4_21799915_ChIP-Seq_A2780_Human1.41588791
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.41178334
56TP53_22573176_ChIP-Seq_HFKS_Human1.40771867
57BCAT_22108803_ChIP-Seq_LS180_Human1.39917030
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.39188216
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.38828157
60STAT3_23295773_ChIP-Seq_U87_Human1.36937683
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.33731600
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.33363650
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33102347
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32800637
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32645321
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32237916
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31220731
68MYC_18940864_ChIP-ChIP_HL60_Human1.31142492
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31136606
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30566783
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30130636
72NANOG_19829295_ChIP-Seq_ESCs_Human1.29332670
73SOX2_19829295_ChIP-Seq_ESCs_Human1.29332670
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28926371
75GATA3_21867929_ChIP-Seq_TH1_Mouse1.28461690
76RUNX2_22187159_ChIP-Seq_PCA_Human1.28136407
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28091200
78TCF4_23295773_ChIP-Seq_U87_Human1.28070803
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.27616335
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27456443
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26910248
82REST_21632747_ChIP-Seq_MESCs_Mouse1.25022296
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.24794505
84TAF15_26573619_Chip-Seq_HEK293_Human1.24338055
85P53_21459846_ChIP-Seq_SAOS-2_Human1.22188458
86LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21342878
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.21206967
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21202707
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20473256
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.20157658
91TCF4_22108803_ChIP-Seq_LS180_Human1.18616733
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17809612
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17253153
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.14792629
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14788822
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.14433267
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13505141
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13258086
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12965545
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12826388
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12826388
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.11783168
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11778383
104EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10909899
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.10816742
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09418470
107HOXB7_26014856_ChIP-Seq_BT474_Human1.09199837
108NCOR_22424771_ChIP-Seq_293T_Human1.09128642
109RNF2_27304074_Chip-Seq_NSC_Mouse1.08792665
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08767485
111AR_20517297_ChIP-Seq_VCAP_Human1.08629062
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07907646
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07559111
114GF1_26923725_Chip-Seq_HPCs_Mouse1.06011155
115ERG_20517297_ChIP-Seq_VCAP_Human1.05800114
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.05535657
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04461807
118FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04026787
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03601868
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.03483480
121MYC_19829295_ChIP-Seq_ESCs_Human1.03430758
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02701188
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.02649417
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.02157437
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02114652
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01911663
127P53_22387025_ChIP-Seq_ESCs_Mouse1.01305304
128ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00687336
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00515980
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00387758
131KLF4_18555785_Chip-Seq_ESCs_Mouse1.00324491
132EZH2_27294783_Chip-Seq_NPCs_Mouse1.00316661
133CDX2_22108803_ChIP-Seq_LS180_Human0.97979034
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.97375757
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97214324
136CMYC_18555785_Chip-Seq_ESCs_Mouse0.97206522
137SPI1_26923725_Chip-Seq_HPCs_Mouse0.97100352
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96410647
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96076527
140ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95705235
141P300_18555785_Chip-Seq_ESCs_Mouse0.95134124
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94974856
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94618962
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94465000
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.94235456
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.94182754
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94080740
148JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93971858
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93213690
150OCT1_27270436_Chip-Seq_PROSTATE_Human0.93081210
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92353913
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.92037382
153SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89718365
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89528579
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89462217
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89281242
157FOXA1_25329375_ChIP-Seq_VCAP_Human0.89281242
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88756453
159PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88241983
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.88004830
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88003268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06012505
2MP0001929_abnormal_gametogenesis5.35478096
3MP0008877_abnormal_DNA_methylation4.11607247
4MP0002653_abnormal_ependyma_morphology3.49536902
5MP0002210_abnormal_sex_determination3.43152958
6MP0002161_abnormal_fertility/fecundity3.32335244
7MP0002837_dystrophic_cardiac_calcinosis3.08929464
8MP0001145_abnormal_male_reproductive2.89935211
9MP0005670_abnormal_white_adipose2.62164786
10MP0003880_abnormal_central_pattern2.60562095
11MP0005623_abnormal_meninges_morphology2.58863053
12MP0000653_abnormal_sex_gland2.51492966
13MP0003195_calcinosis2.36222551
14MP0004885_abnormal_endolymph2.17108448
15MP0005645_abnormal_hypothalamus_physiol2.16816804
16MP0003136_yellow_coat_color2.12576233
17MP0004142_abnormal_muscle_tone2.06035455
18MP0006292_abnormal_olfactory_placode2.02267226
19MP0005410_abnormal_fertilization16.0653088
20MP0003787_abnormal_imprinting1.95630390
21MP0002938_white_spotting1.95099872
22MP0004133_heterotaxia1.94280409
23MP0009745_abnormal_behavioral_response1.94048223
24MP0001968_abnormal_touch/_nociception1.83334250
25MP0000631_abnormal_neuroendocrine_gland1.82336436
26MP0003646_muscle_fatigue1.77975549
27MP0005646_abnormal_pituitary_gland1.77096828
28MP0000372_irregular_coat_pigmentation1.76752422
29MP0002876_abnormal_thyroid_physiology1.76441540
30MP0002282_abnormal_trachea_morphology1.75987009
31MP0006072_abnormal_retinal_apoptosis1.69515778
32MP0002272_abnormal_nervous_system1.67899789
33MP0003122_maternal_imprinting1.61695182
34MP0008875_abnormal_xenobiotic_pharmacok1.59971752
35MP0008872_abnormal_physiological_respon1.58739566
36MP0001485_abnormal_pinna_reflex1.58185949
37MP0005084_abnormal_gallbladder_morpholo1.52446925
38MP0002160_abnormal_reproductive_system1.49943373
39MP0001486_abnormal_startle_reflex1.45872845
40MP0002138_abnormal_hepatobiliary_system1.45778813
41MP0002638_abnormal_pupillary_reflex1.42208797
42MP0001501_abnormal_sleep_pattern1.41393070
43MP0002064_seizures1.40133174
44MP0002557_abnormal_social/conspecific_i1.38905290
45MP0002572_abnormal_emotion/affect_behav1.38652319
46MP0000566_synostosis1.35278552
47MP0003283_abnormal_digestive_organ1.32032990
48MP0001529_abnormal_vocalization1.31681671
49MP0003938_abnormal_ear_development1.29576095
50MP0006276_abnormal_autonomic_nervous1.25787388
51MP0001970_abnormal_pain_threshold1.23819402
52MP0009046_muscle_twitch1.23478971
53MP0001765_abnormal_ion_homeostasis1.23307665
54MP0000026_abnormal_inner_ear1.20088378
55MP0004147_increased_porphyrin_level1.19120056
56MP0004145_abnormal_muscle_electrophysio1.17588645
57MP0001905_abnormal_dopamine_level1.17378944
58MP0008995_early_reproductive_senescence1.17183260
59MP0008789_abnormal_olfactory_epithelium1.16680588
60MP0000427_abnormal_hair_cycle1.16500932
61MP0002733_abnormal_thermal_nociception1.15807417
62MP0000383_abnormal_hair_follicle1.11590169
63MP0005379_endocrine/exocrine_gland_phen1.11436370
64MP0005195_abnormal_posterior_eye1.07922924
65MP0002909_abnormal_adrenal_gland1.07880815
66MP0002735_abnormal_chemical_nociception1.06976659
67MP0002277_abnormal_respiratory_mucosa1.06505327
68MP0002734_abnormal_mechanical_nocicepti1.05846285
69MP0005377_hearing/vestibular/ear_phenot1.05813955
70MP0003878_abnormal_ear_physiology1.05813955
71MP0004233_abnormal_muscle_weight1.05071378
72MP0003635_abnormal_synaptic_transmissio1.05012822
73MP0005647_abnormal_sex_gland1.03893569
74MP0002067_abnormal_sensory_capabilities1.03840473
75MP0003121_genomic_imprinting1.00802290
76MP0005167_abnormal_blood-brain_barrier1.00741930
77MP0005187_abnormal_penis_morphology0.99430698
78MP0002063_abnormal_learning/memory/cond0.98666598
79MP0005386_behavior/neurological_phenoty0.98054486
80MP0004924_abnormal_behavior0.98054486
81MP0001986_abnormal_taste_sensitivity0.97788198
82MP0005174_abnormal_tail_pigmentation0.95856412
83MP0002752_abnormal_somatic_nervous0.94101911
84MP0005423_abnormal_somatic_nervous0.93397802
85MP0002254_reproductive_system_inflammat0.92794259
86MP0000569_abnormal_digit_pigmentation0.92755332
87MP0000778_abnormal_nervous_system0.92661547
88MP0000647_abnormal_sebaceous_gland0.91740672
89MP0000538_abnormal_urinary_bladder0.90197929
90MP0001963_abnormal_hearing_physiology0.89842598
91MP0005075_abnormal_melanosome_morpholog0.89378370
92MP0002095_abnormal_skin_pigmentation0.89116750
93MP0001919_abnormal_reproductive_system0.89008465
94MP0001502_abnormal_circadian_rhythm0.87087171
95MP0010030_abnormal_orbit_morphology0.86160237
96MP0001944_abnormal_pancreas_morphology0.83975156
97MP0001188_hyperpigmentation0.82155397
98MP0000230_abnormal_systemic_arterial0.82078475
99MP0009379_abnormal_foot_pigmentation0.81272151
100MP0002069_abnormal_eating/drinking_beha0.80636275
101MP0002751_abnormal_autonomic_nervous0.80460366
102MP0003950_abnormal_plasma_membrane0.79401981
103MP0008058_abnormal_DNA_repair0.78054140
104MP0005389_reproductive_system_phenotype0.75115207
105MP0005636_abnormal_mineral_homeostasis0.71314196
106MP0005666_abnormal_adipose_tissue0.67035479
107MP0001984_abnormal_olfaction0.65833636
108MP0003115_abnormal_respiratory_system0.64212134
109MP0000358_abnormal_cell_content/0.57189596
110MP0003699_abnormal_female_reproductive0.56186244
111MP0001293_anophthalmia0.52677780
112MP0001324_abnormal_eye_pigmentation0.50081906
113MP0008057_abnormal_DNA_replication0.48251078
114MP0010094_abnormal_chromosome_stability0.48151788
115MP0004036_abnormal_muscle_relaxation0.47688530
116MP0003011_delayed_dark_adaptation0.45962592
117MP0001545_abnormal_hematopoietic_system0.44488300
118MP0005397_hematopoietic_system_phenotyp0.44488300
119MP0001764_abnormal_homeostasis0.44197878
120MP0009278_abnormal_bone_marrow0.44021741
121MP0002295_abnormal_pulmonary_circulatio0.42449193
122MP0009115_abnormal_fat_cell0.41244766
123MP0002928_abnormal_bile_duct0.41133205
124MP0003879_abnormal_hair_cell0.40287134
125MP0003329_amyloid_beta_deposits0.40255608
126MP0003786_premature_aging0.40129866
127MP0002139_abnormal_hepatobiliary_system0.40080904
128MP0002971_abnormal_brown_adipose0.37141320
129MP0008007_abnormal_cellular_replicative0.36455257
130MP0001119_abnormal_female_reproductive0.35523002
131MP0002102_abnormal_ear_morphology0.33372206
132MP0004019_abnormal_vitamin_homeostasis0.32453090
133MP0000751_myopathy0.31855199
134MP0002269_muscular_atrophy0.31509225
135MP0002234_abnormal_pharynx_morphology0.31250378
136MP0001727_abnormal_embryo_implantation0.31117799
137MP0005253_abnormal_eye_physiology0.30805526
138MP0005391_vision/eye_phenotype0.29850580
139MP0004043_abnormal_pH_regulation0.29592581
140MP0008961_abnormal_basal_metabolism0.28817855
141MP0002736_abnormal_nociception_after0.28179885
142MP0005551_abnormal_eye_electrophysiolog0.27522885
143MP0005375_adipose_tissue_phenotype0.26786663
144MP0003633_abnormal_nervous_system0.26032733
145MP0002405_respiratory_system_inflammati0.25834433
146MP0000534_abnormal_ureter_morphology0.25822730
147MP0003942_abnormal_urinary_system0.23416322
148MP0006036_abnormal_mitochondrial_physio0.23193338
149MP0003111_abnormal_nucleus_morphology0.22369281
150MP0002118_abnormal_lipid_homeostasis0.22161434
151MP0002229_neurodegeneration0.21892157
152MP0002092_abnormal_eye_morphology0.21774156
153MP0000604_amyloidosis0.21109526
154MP0004742_abnormal_vestibular_system0.21070099
155MP0003631_nervous_system_phenotype0.20128778
156MP0005058_abnormal_lysosome_morphology0.19929522
157MP0005365_abnormal_bile_salt0.19902445
158MP0003948_abnormal_gas_homeostasis0.19858186
159MP0003045_fibrosis0.19552871
160MP0005388_respiratory_system_phenotype0.18639007
161MP0002133_abnormal_respiratory_system0.18639007
162MP0002152_abnormal_brain_morphology0.18595256
163MP0010329_abnormal_lipoprotein_level0.18593923
164MP0004130_abnormal_muscle_cell0.18221388
165MP0001661_extended_life_span0.17509997
166MP0004811_abnormal_neuron_physiology0.17412073
167MP0003252_abnormal_bile_duct0.16604475
168MP0000313_abnormal_cell_death0.16190679
169MP0003861_abnormal_nervous_system0.15752971
170MP0004270_analgesia0.14948444
171MP0002169_no_abnormal_phenotype0.14620714
172MP0001730_embryonic_growth_arrest0.14519998
173MP0002873_normal_phenotype0.14392783
174MP0001440_abnormal_grooming_behavior0.14357112
175MP0002693_abnormal_pancreas_physiology0.12963004
176MP0005319_abnormal_enzyme/_coenzyme0.12476222
177MP0003936_abnormal_reproductive_system0.12397897
178MP0002796_impaired_skin_barrier0.12081064
179MP0006138_congestive_heart_failure0.11765775

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.11812315
2Abnormal respiratory motile cilium morphology (HP:0005938)8.78940237
3Abnormal respiratory epithelium morphology (HP:0012253)8.78940237
4Rhinitis (HP:0012384)7.66570680
5Abnormal ciliary motility (HP:0012262)7.35658755
6Chronic bronchitis (HP:0004469)6.81489894
7Infertility (HP:0000789)6.76419565
8Nasal polyposis (HP:0100582)6.40716114
9Abnormality of the nasal mucosa (HP:0000433)5.27238764
10Male infertility (HP:0003251)4.79633137
11Bronchitis (HP:0012387)4.77434977
12Nephronophthisis (HP:0000090)4.60514202
13Bronchiectasis (HP:0002110)4.59205310
14Pancreatic cysts (HP:0001737)4.40098409
15Congenital stationary night blindness (HP:0007642)3.80000994
16True hermaphroditism (HP:0010459)3.75294627
17Abnormal spermatogenesis (HP:0008669)3.57757796
18Abnormality of the renal medulla (HP:0100957)3.53103306
19Recurrent sinusitis (HP:0011108)3.48809071
20Recurrent otitis media (HP:0000403)3.44237075
21Recurrent bronchitis (HP:0002837)3.41398365
22Hyperventilation (HP:0002883)3.32445165
23Tubulointerstitial nephritis (HP:0001970)3.09515637
24Impulsivity (HP:0100710)2.94135714
25Attenuation of retinal blood vessels (HP:0007843)2.88552497
26Type II lissencephaly (HP:0007260)2.84956232
27Abnormal rod and cone electroretinograms (HP:0008323)2.83185458
28Gonadotropin excess (HP:0000837)2.82118554
29Tubular atrophy (HP:0000092)2.81649415
30Concave nail (HP:0001598)2.78830519
31Tubulointerstitial abnormality (HP:0001969)2.74255017
32Gait imbalance (HP:0002141)2.61904388
33Increased corneal curvature (HP:0100692)2.56030071
34Keratoconus (HP:0000563)2.56030071
35Chronic hepatic failure (HP:0100626)2.54336816
36Abolished electroretinogram (ERG) (HP:0000550)2.54148172
37Abnormality of midbrain morphology (HP:0002418)2.52634108
38Molar tooth sign on MRI (HP:0002419)2.52634108
39Sclerocornea (HP:0000647)2.51407674
40Pendular nystagmus (HP:0012043)2.51399135
41Nephrogenic diabetes insipidus (HP:0009806)2.49404548
42Congenital primary aphakia (HP:0007707)2.48042066
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45533434
44Abnormality of alanine metabolism (HP:0010916)2.44504847
45Hyperalaninemia (HP:0003348)2.44504847
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44504847
47Abnormality of the labia minora (HP:0012880)2.41289871
48Anencephaly (HP:0002323)2.39465940
49Polyuria (HP:0000103)2.37064400
50Choroideremia (HP:0001139)2.36774284
51Cholecystitis (HP:0001082)2.32757219
52Abnormal gallbladder physiology (HP:0012438)2.32757219
53Azoospermia (HP:0000027)2.32017036
54Gaze-evoked nystagmus (HP:0000640)2.28235449
55Congenital, generalized hypertrichosis (HP:0004540)2.28150512
56Tubulointerstitial fibrosis (HP:0005576)2.28069125
57Spastic tetraparesis (HP:0001285)2.22944582
58Mitochondrial inheritance (HP:0001427)2.22823504
59Acute necrotizing encephalopathy (HP:0006965)2.21448230
60Furrowed tongue (HP:0000221)2.21065573
61Renal cortical cysts (HP:0000803)2.20997296
62Methylmalonic acidemia (HP:0002912)2.20748218
63Genital tract atresia (HP:0001827)2.19929971
64Inability to walk (HP:0002540)2.19420513
65Lipid accumulation in hepatocytes (HP:0006561)2.18544284
66Lissencephaly (HP:0001339)2.16105971
67Vaginal atresia (HP:0000148)2.14176772
68Congenital sensorineural hearing impairment (HP:0008527)2.10988611
69Abnormal biliary tract physiology (HP:0012439)2.05892059
70Bile duct proliferation (HP:0001408)2.05892059
71Increased CSF lactate (HP:0002490)2.05275110
72Medial flaring of the eyebrow (HP:0010747)2.03082683
73Progressive macrocephaly (HP:0004481)2.02695498
74Febrile seizures (HP:0002373)2.02579455
75Optic disc pallor (HP:0000543)2.02358846
76Increased hepatocellular lipid droplets (HP:0006565)2.01273319
77Focal motor seizures (HP:0011153)2.01261787
78Acute encephalopathy (HP:0006846)2.00872044
79Abnormality of the lower motor neuron (HP:0002366)2.00651467
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4453779
81Absent/shortened dynein arms (HP:0200106)12.9271179
82Dynein arm defect of respiratory motile cilia (HP:0012255)12.9271179
83Male pseudohermaphroditism (HP:0000037)1.99724837
84Dyschromatopsia (HP:0007641)1.99528285
85Heterotopia (HP:0002282)1.99386688
86Postaxial foot polydactyly (HP:0001830)1.98959311
87Broad-based gait (HP:0002136)1.98016160
88Large for gestational age (HP:0001520)1.97729831
89Patellar aplasia (HP:0006443)1.96987938
90Anophthalmia (HP:0000528)1.96783597
91Chorioretinal atrophy (HP:0000533)1.96066481
92Stomach cancer (HP:0012126)1.95131411
93Aplasia/hypoplasia of the uterus (HP:0008684)1.95019968
94Bony spicule pigmentary retinopathy (HP:0007737)1.94219736
95Optic nerve hypoplasia (HP:0000609)1.93429370
96Stage 5 chronic kidney disease (HP:0003774)1.92440212
97Aplasia/Hypoplasia of the patella (HP:0006498)1.90473193
98Hypothermia (HP:0002045)1.89532549
99Short ribs (HP:0000773)1.88876425
100Absent frontal sinuses (HP:0002688)1.88616335
101Retinal dysplasia (HP:0007973)1.87989789
1023-Methylglutaconic aciduria (HP:0003535)1.87881433
103Gastrointestinal atresia (HP:0002589)1.87858806
104Progressive cerebellar ataxia (HP:0002073)1.86227060
105Methylmalonic aciduria (HP:0012120)1.85623561
106Thyroid-stimulating hormone excess (HP:0002925)1.83388276
107Esophageal atresia (HP:0002032)1.82727356
108J-shaped sella turcica (HP:0002680)1.82425780
109Hypomagnesemia (HP:0002917)1.82272313
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81602583
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.80788312
112Intestinal atresia (HP:0011100)1.80727874
113Decreased central vision (HP:0007663)1.80694558
114Microglossia (HP:0000171)1.80343186
115Decreased circulating renin level (HP:0003351)1.80330445
116Fibular hypoplasia (HP:0003038)1.79088489
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.78946441
118Congenital hepatic fibrosis (HP:0002612)1.78697592
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78539176
120Bell-shaped thorax (HP:0001591)1.78280430
121Oligodactyly (hands) (HP:0001180)1.76789051
122Occipital encephalocele (HP:0002085)1.76745431
123Abnormal drinking behavior (HP:0030082)1.75166234
124Polydipsia (HP:0001959)1.75166234
125Abnormality of the renal cortex (HP:0011035)1.74754370
126Dialeptic seizures (HP:0011146)1.73266005
127Abnormality of dentin (HP:0010299)1.72196745
128Hemorrhage of the eye (HP:0011885)1.67925401
129Abnormality of the dental root (HP:0006486)1.67302787
130Taurodontia (HP:0000679)1.67302787
131Abnormality of permanent molar morphology (HP:0011071)1.67302787
132Abnormality of renal excretion (HP:0011036)1.63785495
133Amyotrophic lateral sclerosis (HP:0007354)1.63455016
134Renal dysplasia (HP:0000110)1.61450983
135Oculomotor apraxia (HP:0000657)1.61224738
136Deformed sella turcica (HP:0002681)1.59688505
137Abnormality of molar (HP:0011077)1.56610021
138Abnormality of molar morphology (HP:0011070)1.56610021
139Neurofibrillary tangles (HP:0002185)1.54339569
140Hemiparesis (HP:0001269)1.53825851
141Abnormality of the dental pulp (HP:0006479)1.50642288
142Cystic liver disease (HP:0006706)1.47126881
143Asymmetric septal hypertrophy (HP:0001670)1.47046903
144Short thorax (HP:0010306)1.44063211
145Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.43490013
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39114190
147Absent epiphyses (HP:0010577)1.39114190
148Postaxial hand polydactyly (HP:0001162)1.39032214
149Pancreatic fibrosis (HP:0100732)1.36502806
150Glucose intolerance (HP:0000833)1.35001775
151Abnormal urine output (HP:0012590)1.32840766
152Facial cleft (HP:0002006)1.32133993
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.31125234
154Impaired proprioception (HP:0010831)1.30503099
155Cerebral inclusion bodies (HP:0100314)1.30119102
156Nephropathy (HP:0000112)1.29945279
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.29311435
158Vascular calcification (HP:0004934)1.28650193
159Bundle branch block (HP:0011710)1.27232811
160Pachygyria (HP:0001302)1.25576420
161Broad distal phalanx of finger (HP:0009836)1.24356678
162Supernumerary spleens (HP:0009799)1.23765519
163Chronic sinusitis (HP:0011109)1.23708464
164Loss of speech (HP:0002371)1.22665451
165Median cleft lip (HP:0000161)1.21999163
166Short femoral neck (HP:0100864)1.17582684
167Abnormality of the sella turcica (HP:0002679)1.16502645
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.16361491
169Abnormality of saccadic eye movements (HP:0000570)1.15979892
170Hypercholesterolemia (HP:0003124)1.15808071
171Hypopigmentation of the fundus (HP:0007894)1.14989644
172Cardiovascular calcification (HP:0011915)1.14771779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.95724821
2PDK47.95724821
3TESK15.97066392
4PRKD35.43909577
5FRK5.39195574
6PDK25.15319180
7ICK4.17222856
8MAP4K23.27619153
9ADRBK22.98782502
10PNCK2.92530106
11CASK2.81843400
12WNK42.76103904
13PTK2B2.61675952
14GRK12.49405877
15FGFR22.41308989
16ZAK2.39138992
17STK392.28090075
18TLK12.25779680
19TAOK32.11070355
20ACVR1B1.97881888
21MAPK131.90586404
22NUAK11.79629823
23INSRR1.73352906
24STK381.63039952
25DYRK1B1.59191603
26NEK21.44999293
27STK161.43851935
28NTRK31.31910865
29DYRK21.28821499
30MARK11.28531027
31OXSR11.28313288
32PAK31.27179133
33MKNK21.20885353
34WNK11.20815439
35TGFBR11.20571158
36TRIM281.19191324
37TNIK1.17228419
38ADRBK11.14420540
39TYRO31.11714918
40DAPK21.09096973
41PHKG11.09074360
42PHKG21.09074360
43PDK11.00919569
44PRKCE0.98117069
45CAMK1G0.95347955
46BCKDK0.91307552
47MAPK150.90745380
48CSNK1G10.85657971
49CSNK1G20.83987249
50PLK20.80105105
51TXK0.80092944
52VRK10.79979961
53DYRK30.77553063
54SGK20.75929211
55ERBB30.74748609
56PIK3CA0.73932456
57CSNK1G30.73481004
58SGK4940.73418065
59SGK2230.73418065
60TTK0.70614655
61MST40.70284938
62STK30.66699049
63PASK0.65514396
64LMTK20.64367160
65IKBKB0.64212195
66TIE10.63352149
67MAP2K60.62721501
68CAMK10.61355247
69EEF2K0.58911878
70AKT30.57193387
71RPS6KA50.54022560
72CCNB10.52215036
73PDPK10.51876609
74FLT30.51872612
75CSNK1A1L0.51470974
76CHEK20.51226919
77IRAK10.50871177
78CDK30.50581265
79RIPK40.49760220
80CAMKK20.48353119
81PRKACA0.48323529
82CSNK1A10.46374507
83MKNK10.46358735
84CHEK10.45458519
85TESK20.45172179
86EPHB20.42910600
87NEK60.42893828
88PAK10.42581202
89BCR0.42466589
90CHUK0.41339796
91WEE10.41119321
92STK38L0.40378073
93PRKCI0.39965563
94DYRK1A0.39559707
95FER0.39526997
96VRK20.39380729
97PAK20.38767728
98PLK30.37717378
99PINK10.36002702
100EPHA40.35610614
101ERBB20.35017088
102OBSCN0.34940768
103MTOR0.34699779
104CAMK2D0.34386758
105ATR0.33646702
106PRKCG0.33091346
107ATM0.32545118
108SIK20.31136475
109MARK20.30880575
110FGFR10.29827201
111NTRK20.29463799
112BMPR1B0.29435950
113STK240.29012584
114CDC70.28957310
115KIT0.28057834
116MAP3K90.27922207
117PRKCH0.27831681
118IRAK20.27095581
119PAK40.26747560
120MAP4K10.24433834
121MAP3K40.22944289
122PRKAA10.21857034
123PLK40.21167005
124RPS6KB10.19646208
125ZAP700.18761836
126MUSK0.17763319
127MAPKAPK50.16225566
128MAP2K70.13689718
129CAMKK10.13472424
130EPHB10.13093865
131CSNK1D0.12840739
132PRKCQ0.11854686
133STK100.11651651
134PRKCZ0.10348664
135PLK10.10052035
136TAOK10.09756351
137PAK60.09392722
138GSK3B0.08993092
139WNK30.08932214
140CDK120.08680452
141PRKCD0.07576766
142EGFR0.07321032
143BLK0.06708074
144PKN10.06652702
145PRKDC0.05390170
146CDK10.05126836
147PRKACB0.04125383
148RPS6KA10.03976589
149CDK20.03887443
150MAPK80.03698543
151CAMK2A0.03567110
152CSF1R0.03422085
153CDK150.03347952
154PRKCB0.02700402
155STK110.02682908
156CSNK2A10.02331550
157MAP3K10.01860314
158CDK60.01764592
159PRKACG0.01654889
160MAPK10.01609585
161PRKG10.01172005
162MAP3K100.00810473
163CDK180.00343182
164CSNK2A20.00269588
165PRKCA0.00189602
166CSK-7.7470341
167LATS1-0.0072929
168BRSK2-0.0036796
169PDGFRB-0.0027700
170CDK11A-0.0013605
171SRC-0.0009011

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.47527671
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.42304776
3Pyruvate metabolism_Homo sapiens_hsa006203.37305078
4Vitamin B6 metabolism_Homo sapiens_hsa007503.23264133
5Oxidative phosphorylation_Homo sapiens_hsa001902.88116171
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86844070
7Propanoate metabolism_Homo sapiens_hsa006402.84076718
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.82963332
9Phototransduction_Homo sapiens_hsa047442.78131998
10Nitrogen metabolism_Homo sapiens_hsa009102.68474276
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.60215183
12Linoleic acid metabolism_Homo sapiens_hsa005912.50725450
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49820577
14Glucagon signaling pathway_Homo sapiens_hsa049222.42886413
15Dorso-ventral axis formation_Homo sapiens_hsa043202.40147447
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33066059
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29892256
18PPAR signaling pathway_Homo sapiens_hsa033202.18188391
19Nicotine addiction_Homo sapiens_hsa050332.18019864
20Carbohydrate digestion and absorption_Homo sapiens_hsa049732.17795478
21Glycerolipid metabolism_Homo sapiens_hsa005612.14890651
22Parkinsons disease_Homo sapiens_hsa050122.13546664
23Maturity onset diabetes of the young_Homo sapiens_hsa049502.11183064
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05508252
25Butanoate metabolism_Homo sapiens_hsa006502.02739645
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00955759
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89344091
28Basal transcription factors_Homo sapiens_hsa030221.83687059
29Selenocompound metabolism_Homo sapiens_hsa004501.80767504
30Tryptophan metabolism_Homo sapiens_hsa003801.79452412
31Pentose phosphate pathway_Homo sapiens_hsa000301.74769986
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72733452
33Fatty acid metabolism_Homo sapiens_hsa012121.65312472
34Oocyte meiosis_Homo sapiens_hsa041141.62459855
35Fructose and mannose metabolism_Homo sapiens_hsa000511.61865997
36Protein export_Homo sapiens_hsa030601.61342777
37Fatty acid degradation_Homo sapiens_hsa000711.61317880
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.54244709
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.53567382
40Mineral absorption_Homo sapiens_hsa049781.52778327
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49516572
42Sulfur relay system_Homo sapiens_hsa041221.49348911
43Carbon metabolism_Homo sapiens_hsa012001.44617036
44RNA polymerase_Homo sapiens_hsa030201.40959398
45Morphine addiction_Homo sapiens_hsa050321.39873181
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.39490559
47Fanconi anemia pathway_Homo sapiens_hsa034601.37847181
48Alzheimers disease_Homo sapiens_hsa050101.37626690
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36277114
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35656756
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34989901
52Huntingtons disease_Homo sapiens_hsa050161.28623941
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26761127
54Ribosome_Homo sapiens_hsa030101.23780808
55Amphetamine addiction_Homo sapiens_hsa050311.23132340
56Ovarian steroidogenesis_Homo sapiens_hsa049131.22278985
57Caffeine metabolism_Homo sapiens_hsa002321.21670648
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19988439
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.19613986
60Fat digestion and absorption_Homo sapiens_hsa049751.19074506
61Ether lipid metabolism_Homo sapiens_hsa005651.18889076
62Antigen processing and presentation_Homo sapiens_hsa046121.17975257
63Olfactory transduction_Homo sapiens_hsa047401.16463612
64Renin secretion_Homo sapiens_hsa049241.16062705
65Peroxisome_Homo sapiens_hsa041461.16035082
66Glutamatergic synapse_Homo sapiens_hsa047241.15621319
67mRNA surveillance pathway_Homo sapiens_hsa030151.15053066
68Serotonergic synapse_Homo sapiens_hsa047261.14536252
69Cardiac muscle contraction_Homo sapiens_hsa042601.14151212
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13855859
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12105938
72GABAergic synapse_Homo sapiens_hsa047271.09861321
73Homologous recombination_Homo sapiens_hsa034401.05048465
74Cysteine and methionine metabolism_Homo sapiens_hsa002701.02960823
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02936819
76ABC transporters_Homo sapiens_hsa020101.02534507
77RNA degradation_Homo sapiens_hsa030181.01687199
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.99930999
79Biosynthesis of amino acids_Homo sapiens_hsa012300.97651936
80Retinol metabolism_Homo sapiens_hsa008300.96386585
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94590172
82Legionellosis_Homo sapiens_hsa051340.94385960
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.93700471
84Renin-angiotensin system_Homo sapiens_hsa046140.93660070
85RNA transport_Homo sapiens_hsa030130.91753935
86Folate biosynthesis_Homo sapiens_hsa007900.90476577
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89476546
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.86204753
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86006947
90Collecting duct acid secretion_Homo sapiens_hsa049660.84601543
91Chemical carcinogenesis_Homo sapiens_hsa052040.82602402
92One carbon pool by folate_Homo sapiens_hsa006700.78328021
93Staphylococcus aureus infection_Homo sapiens_hsa051500.77650081
94Purine metabolism_Homo sapiens_hsa002300.77403772
95Estrogen signaling pathway_Homo sapiens_hsa049150.76839163
96Dopaminergic synapse_Homo sapiens_hsa047280.76602668
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74809945
98Asthma_Homo sapiens_hsa053100.73812062
99Glutathione metabolism_Homo sapiens_hsa004800.73482861
100Thyroid hormone synthesis_Homo sapiens_hsa049180.70639956
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70102108
102Complement and coagulation cascades_Homo sapiens_hsa046100.68793552
103Insulin secretion_Homo sapiens_hsa049110.67805402
104Bile secretion_Homo sapiens_hsa049760.67313834
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63781881
106Hedgehog signaling pathway_Homo sapiens_hsa043400.62133894
107Arachidonic acid metabolism_Homo sapiens_hsa005900.60578334
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60504615
109Type I diabetes mellitus_Homo sapiens_hsa049400.60343629
110Long-term potentiation_Homo sapiens_hsa047200.57599921
111Calcium signaling pathway_Homo sapiens_hsa040200.57375685
112Salivary secretion_Homo sapiens_hsa049700.54462429
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54001885
114beta-Alanine metabolism_Homo sapiens_hsa004100.53665004
115Regulation of autophagy_Homo sapiens_hsa041400.52869043
116Taste transduction_Homo sapiens_hsa047420.52791424
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52006989
118Endocytosis_Homo sapiens_hsa041440.51362806
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50611734
120Protein digestion and absorption_Homo sapiens_hsa049740.48777977
121Proteasome_Homo sapiens_hsa030500.48337515
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48233277
123Rheumatoid arthritis_Homo sapiens_hsa053230.47774108
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.46835812
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46065616
126Synaptic vesicle cycle_Homo sapiens_hsa047210.45025541
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42578628
128AMPK signaling pathway_Homo sapiens_hsa041520.42409927
129Sulfur metabolism_Homo sapiens_hsa009200.42028749
130Histidine metabolism_Homo sapiens_hsa003400.41098531
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40390251
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40387286
133Long-term depression_Homo sapiens_hsa047300.40002711
134Inositol phosphate metabolism_Homo sapiens_hsa005620.39589828
135Circadian rhythm_Homo sapiens_hsa047100.38431155
136Other glycan degradation_Homo sapiens_hsa005110.37091756
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36131083
138Cholinergic synapse_Homo sapiens_hsa047250.35946700
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35689362
140Pancreatic secretion_Homo sapiens_hsa049720.34948318
141Gastric acid secretion_Homo sapiens_hsa049710.32007892
142cAMP signaling pathway_Homo sapiens_hsa040240.31197063
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29566177
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.29081108
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28775658
146Metabolic pathways_Homo sapiens_hsa011000.28609182
147VEGF signaling pathway_Homo sapiens_hsa043700.27515192
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27209923
149Salmonella infection_Homo sapiens_hsa051320.27123984
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27014694
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26486712
152Circadian entrainment_Homo sapiens_hsa047130.26290943
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25774613
154Vitamin digestion and absorption_Homo sapiens_hsa049770.22991960
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.19036146
156Sphingolipid metabolism_Homo sapiens_hsa006000.18785122
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16566502
158Toxoplasmosis_Homo sapiens_hsa051450.14188315
159Type II diabetes mellitus_Homo sapiens_hsa049300.13908452
160Cocaine addiction_Homo sapiens_hsa050300.11312984

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