PRR30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.96833655
2acrosome assembly (GO:0001675)9.91504477
3spermatid development (GO:0007286)9.65061518
4response to pheromone (GO:0019236)9.51047844
5reproduction (GO:0000003)9.49727850
6cilium movement (GO:0003341)8.35748926
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.05693258
8piRNA metabolic process (GO:0034587)8.00302075
9single fertilization (GO:0007338)7.80349640
10sperm capacitation (GO:0048240)7.32038203
11male meiosis (GO:0007140)7.13824118
12rRNA methylation (GO:0031167)7.08164677
13synaptonemal complex organization (GO:0070193)6.94378481
14negative regulation of inclusion body assembly (GO:0090084)6.89155842
15phosphatidylethanolamine biosynthetic process (GO:0006646)6.61357841
16microtubule depolymerization (GO:0007019)6.59769006
17fertilization (GO:0009566)6.54505267
18synaptonemal complex assembly (GO:0007130)6.46179641
19spermatogenesis (GO:0007283)6.42070624
20male gamete generation (GO:0048232)6.39669692
21organic cation transport (GO:0015695)6.23498243
22cellular ketone body metabolic process (GO:0046950)6.10135850
23phosphatidylethanolamine metabolic process (GO:0046337)6.09953790
24regulation of microtubule-based movement (GO:0060632)6.05760107
25rRNA modification (GO:0000154)5.96424747
26protein targeting to Golgi (GO:0000042)5.95479366
27gamete generation (GO:0007276)5.87848680
28establishment of protein localization to Golgi (GO:0072600)5.71510659
29regulation of inclusion body assembly (GO:0090083)5.69561922
30ventricular system development (GO:0021591)5.61476165
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.54496370
32calcium ion-dependent exocytosis (GO:0017156)5.47593739
33germ cell development (GO:0007281)5.40306653
34ketone body metabolic process (GO:1902224)5.38723013
35male meiosis I (GO:0007141)5.33693473
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.32876740
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.22995540
38left/right pattern formation (GO:0060972)5.08680514
39positive regulation of Rab GTPase activity (GO:0032851)4.92846292
40regulation of Rab GTPase activity (GO:0032313)4.92846292
41DNA methylation involved in gamete generation (GO:0043046)4.92747789
42cell recognition (GO:0008037)4.86437851
43chromatin silencing (GO:0006342)4.84812215
44centriole replication (GO:0007099)4.82062377
45multicellular organismal reproductive process (GO:0048609)4.66828315
46microtubule severing (GO:0051013)4.57889952
47glycerol ether metabolic process (GO:0006662)4.55556940
48regulation of transcription involved in cell fate commitment (GO:0060850)4.47585895
49chromosome organization involved in meiosis (GO:0070192)4.42716909
50seminiferous tubule development (GO:0072520)4.41438988
51centriole assembly (GO:0098534)4.35086019
52meiotic nuclear division (GO:0007126)4.27876854
53protein localization to Golgi apparatus (GO:0034067)4.26184087
54meiosis I (GO:0007127)4.25084945
55ether metabolic process (GO:0018904)4.20516734
56coenzyme catabolic process (GO:0009109)4.12324683
57negative regulation of Rho protein signal transduction (GO:0035024)4.09168142
58regulation of somitogenesis (GO:0014807)4.01514880
59chromosome condensation (GO:0030261)3.80704628
60regulation of centriole replication (GO:0046599)3.79728045
61chaperone-mediated protein complex assembly (GO:0051131)3.77417567
62protein polyglutamylation (GO:0018095)3.76547952
63multicellular organismal development (GO:0007275)3.73753056
64polyamine biosynthetic process (GO:0006596)3.72867148
65genitalia morphogenesis (GO:0035112)3.69565302
66DNA packaging (GO:0006323)3.66608722
67meiotic cell cycle (GO:0051321)3.61383351
68spermatid nucleus differentiation (GO:0007289)3.59812926
69protein localization to cilium (GO:0061512)3.55706569
70protein refolding (GO:0042026)3.54750543
71protein-DNA complex disassembly (GO:0032986)3.53395924
72nucleosome disassembly (GO:0006337)3.53395924
73musculoskeletal movement (GO:0050881)3.49475802
74multicellular organismal movement (GO:0050879)3.49475802
75peptidyl-threonine dephosphorylation (GO:0035970)3.47824697
76monoubiquitinated protein deubiquitination (GO:0035520)3.47468815
77carnitine transport (GO:0015879)3.40739868
78amino-acid betaine transport (GO:0015838)3.40739868
79microtubule polymerization or depolymerization (GO:0031109)3.37254406
80regulation of spindle checkpoint (GO:0090231)3.36623595
81cranial nerve morphogenesis (GO:0021602)3.33538326
82regulation of interleukin-13 production (GO:0032656)3.32185220
83negative regulation of gene expression, epigenetic (GO:0045814)3.31827310
84cellular response to pH (GO:0071467)3.31697602
85cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.30347394
86membrane protein intracellular domain proteolysis (GO:0031293)3.28924292
87cerebral cortex neuron differentiation (GO:0021895)3.28241083
88regulation of T-helper 2 cell differentiation (GO:0045628)3.26813823
89carnitine transmembrane transport (GO:1902603)3.25080216
90histone H3-K9 demethylation (GO:0033169)3.24624414
91polyol catabolic process (GO:0046174)3.20397107
92mesenchymal cell differentiation involved in kidney development (GO:0072161)3.18771803
93mesenchymal cell differentiation involved in renal system development (GO:2001012)3.18771803
94homeostasis of number of cells within a tissue (GO:0048873)3.18247151
95glycolytic process (GO:0006096)3.18185084
96protein depolymerization (GO:0051261)3.15896328
97mitotic sister chromatid cohesion (GO:0007064)3.12031299
98gene silencing by RNA (GO:0031047)3.11520439
99RNA localization (GO:0006403)3.10966928
100RNA destabilization (GO:0050779)3.07710518
101DNA conformation change (GO:0071103)3.06855461
102cell differentiation involved in metanephros development (GO:0072202)3.02134583
103cilium organization (GO:0044782)3.01993903
104negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.00079412
105tooth mineralization (GO:0034505)2.99504392
106microtubule-based movement (GO:0007018)2.99022002
107alditol metabolic process (GO:0019400)2.98871561
108negative regulation of organelle assembly (GO:1902116)2.96326694
109nucleus organization (GO:0006997)2.96236378
110negative regulation of skeletal muscle tissue development (GO:0048642)2.91438673
111cilium assembly (GO:0042384)2.90712662
112glomerular visceral epithelial cell development (GO:0072015)2.90685229
113NAD biosynthetic process (GO:0009435)2.89927010
114peptidyl-glutamic acid modification (GO:0018200)2.87365740
115glomerular epithelial cell development (GO:0072310)2.86971863
116interferon-gamma secretion (GO:0072643)2.86628554
117nucleoside diphosphate phosphorylation (GO:0006165)2.86465882
118negative regulation of histone methylation (GO:0031061)2.83084578
119sexual reproduction (GO:0019953)2.82986531
120regulation of phosphoprotein phosphatase activity (GO:0043666)2.82229804
121single strand break repair (GO:0000012)2.81777819
122cilium morphogenesis (GO:0060271)2.81766814
123positive regulation of skeletal muscle tissue development (GO:0048643)2.81728403
124intraciliary transport (GO:0042073)2.80996859
125lactate metabolic process (GO:0006089)2.76495190
126nuclear pore complex assembly (GO:0051292)2.76309866
127meiotic cell cycle process (GO:1903046)2.75548854
128axoneme assembly (GO:0035082)2.75095375
129regulation of protein kinase C signaling (GO:0090036)2.70707804
130cellular component assembly involved in morphogenesis (GO:0010927)2.70532475
131regulation of meiosis I (GO:0060631)2.69311121
132synapsis (GO:0007129)2.66627059
133regulation of protein kinase A signaling (GO:0010738)2.64734763
134protein K11-linked deubiquitination (GO:0035871)2.64126103
135regulation of cilium assembly (GO:1902017)2.61490305
136response to acidic pH (GO:0010447)2.50652696
137calcium ion import (GO:0070509)2.49775258
138fusion of sperm to egg plasma membrane (GO:0007342)13.9987536
139sperm motility (GO:0030317)13.9731945
140acrosome reaction (GO:0007340)12.1327794
141multicellular organism reproduction (GO:0032504)11.4022536
142sperm-egg recognition (GO:0035036)11.2410446
143cilium or flagellum-dependent cell motility (GO:0001539)11.1362892
144axonemal dynein complex assembly (GO:0070286)10.7767534
145plasma membrane fusion (GO:0045026)10.6759956
146epithelial cilium movement (GO:0003351)10.2042121
147regulation of cilium movement (GO:0003352)10.1666014
148cell wall macromolecule metabolic process (GO:0044036)10.1259491
149cell wall macromolecule catabolic process (GO:0016998)10.1259491
150binding of sperm to zona pellucida (GO:0007339)10.0909345
151cell-cell recognition (GO:0009988)10.0516601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.68846016
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.80935753
3EZH2_22144423_ChIP-Seq_EOC_Human4.47717525
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.04807982
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.77140187
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66434865
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07197380
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01817201
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79154532
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.67902896
11VDR_22108803_ChIP-Seq_LS180_Human2.54577700
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25485597
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12672997
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01296882
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.99502416
16ERA_21632823_ChIP-Seq_H3396_Human1.96982628
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93112337
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.90728656
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89884590
20DROSHA_22980978_ChIP-Seq_HELA_Human1.88986471
21CTCF_27219007_Chip-Seq_Bcells_Human1.88619977
22RAC3_21632823_ChIP-Seq_H3396_Human1.87047904
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.86346600
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85727734
25ZNF274_21170338_ChIP-Seq_K562_Hela1.79456652
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77869406
27BCL6_27268052_Chip-Seq_Bcells_Human1.74397166
28STAT1_17558387_ChIP-Seq_HELA_Human1.74218684
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.73409317
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.72895461
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71564980
32E2F1_20622854_ChIP-Seq_HELA_Human1.70255644
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.68008551
34SMC4_20622854_ChIP-Seq_HELA_Human1.65846144
35TAF2_19829295_ChIP-Seq_ESCs_Human1.65313637
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65034355
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64637459
38BCOR_27268052_Chip-Seq_Bcells_Human1.63197220
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61905243
40P68_20966046_ChIP-Seq_HELA_Human1.59671218
41PHF8_20622854_ChIP-Seq_HELA_Human1.58830191
42LXR_22292898_ChIP-Seq_THP-1_Human1.58613701
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57181403
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.54451810
45TP63_22573176_ChIP-Seq_HFKS_Human1.53470239
46CBP_20019798_ChIP-Seq_JUKART_Human1.50850550
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50850550
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49983183
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49826376
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48497829
51PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46733465
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.46318122
53OCT4_20526341_ChIP-Seq_ESCs_Human1.44419587
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42670010
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.41308351
56KDM2B_26808549_Chip-Seq_REH_Human1.41187008
57P300_27268052_Chip-Seq_Bcells_Human1.39619632
58ER_23166858_ChIP-Seq_MCF-7_Human1.38823548
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38255297
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37851223
61TP53_18474530_ChIP-ChIP_U2OS_Human1.37546353
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36579279
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36517063
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34642679
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34524920
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34308126
67AR_25329375_ChIP-Seq_VCAP_Human1.33951608
68HNFA_21074721_ChIP-Seq_CACO-2_Human1.33153216
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32725731
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30877153
71REST_21632747_ChIP-Seq_MESCs_Mouse1.30716856
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29160825
73CBX2_22325352_ChIP-Seq_293T-Rex_Human1.29018158
74RBPJ_21746931_ChIP-Seq_IB4_Human1.28972183
75RUNX_20019798_ChIP-Seq_JUKART_Human1.28339158
76GATA3_21867929_ChIP-Seq_CD8_Mouse1.27749457
77KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27331884
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26987651
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26824668
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.25994941
81P53_21459846_ChIP-Seq_SAOS-2_Human1.25980179
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.25481692
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24016022
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.22402618
85CEBPB_22108803_ChIP-Seq_LS180_Human1.21928744
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.21646942
87TAF15_26573619_Chip-Seq_HEK293_Human1.21538174
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.21306143
89SA1_27219007_Chip-Seq_Bcells_Human1.18117400
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17466662
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.17192238
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16271603
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16073489
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15996548
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15972333
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.15347956
97RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15051286
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14983955
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14516610
100GF1_26923725_Chip-Seq_HPCs_Mouse1.14467417
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.14211574
102SMRT_27268052_Chip-Seq_Bcells_Human1.13536230
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13235473
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13082047
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13082047
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.12913347
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11455258
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10734833
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10467825
110EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10046395
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09754462
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08716467
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07898424
114P300_19829295_ChIP-Seq_ESCs_Human1.07559863
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07129582
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06405322
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06103081
118CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05348377
119SA1_27219007_Chip-Seq_ERYTHROID_Human1.05141845
120SPI1_26923725_Chip-Seq_HPCs_Mouse1.04645093
121CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03927810
122GATA6_21074721_ChIP-Seq_CACO-2_Human1.03763834
123MYC_27129775_Chip-Seq_CORNEA_Mouse1.03432688
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.02567049
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.02551624
126PHF8_20622853_ChIP-Seq_HELA_Human1.02145181
127SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01244481
128ERG_20517297_ChIP-Seq_VCAP_Human1.00810022
129CTCF_20526341_ChIP-Seq_ESCs_Human1.00432381
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99621500
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99364422
132OCT1_27270436_Chip-Seq_PROSTATE_Human0.99177343
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98633864
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97515478
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97475262
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97191264
137SOX2_19829295_ChIP-Seq_ESCs_Human0.96870589
138NANOG_19829295_ChIP-Seq_ESCs_Human0.96870589
139NFYB_21822215_ChIP-Seq_K562_Human0.96864262
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.96633607
141TBL1_22424771_ChIP-Seq_293T_Human0.96512131
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96094762
143PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94360763
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.93219964
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.92760778
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92510627
147FUS_26573619_Chip-Seq_HEK293_Human0.92378490
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.91996901
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.91390402
150SOX2_21211035_ChIP-Seq_LN229_Human0.90769138
151MYC_19829295_ChIP-Seq_ESCs_Human0.90508899
152NANOG_20526341_ChIP-Seq_ESCs_Human0.90063023
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89977163
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89622098
155ESET_19884257_ChIP-Seq_ESCs_Mouse0.89404730
156RNF2_27304074_Chip-Seq_NSC_Mouse0.89311489
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88742384
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88424062
159RARA_24833708_ChIP-Seq_LIVER_Mouse0.88359638
160SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88203791
161STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88183394
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.87879286
163JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87614694
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87504240
165SMAD3_21741376_ChIP-Seq_ESCs_Human0.86455611
166ETV1_20927104_ChIP-Seq_GIST48_Human0.86402329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.03724762
2MP0001929_abnormal_gametogenesis5.31596727
3MP0008877_abnormal_DNA_methylation4.24049166
4MP0002210_abnormal_sex_determination3.33565571
5MP0002161_abnormal_fertility/fecundity3.32249907
6MP0001348_abnormal_lacrimal_gland3.25405861
7MP0005670_abnormal_white_adipose3.16080823
8MP0002653_abnormal_ependyma_morphology2.85790991
9MP0000678_abnormal_parathyroid_gland2.82950651
10MP0001145_abnormal_male_reproductive2.80177178
11MP0000653_abnormal_sex_gland2.42056983
12MP0003718_maternal_effect2.21495713
13MP0002132_abnormal_respiratory_system2.05910665
14MP0005410_abnormal_fertilization16.2713863
15MP0005623_abnormal_meninges_morphology1.88556857
16MP0002249_abnormal_larynx_morphology1.77305733
17MP0002282_abnormal_trachea_morphology1.69250489
18MP0009053_abnormal_anal_canal1.51218579
19MP0003646_muscle_fatigue1.50930656
20MP0004510_myositis1.48702538
21MP0005379_endocrine/exocrine_gland_phen1.44154989
22MP0005310_abnormal_salivary_gland1.43563460
23MP0002160_abnormal_reproductive_system1.40166932
24MP0001485_abnormal_pinna_reflex1.35214649
25MP0001486_abnormal_startle_reflex1.29365218
26MP0001765_abnormal_ion_homeostasis1.28851338
27MP0002735_abnormal_chemical_nociception1.20050081
28MP0004233_abnormal_muscle_weight1.18949760
29MP0002127_abnormal_cardiovascular_syste1.15750867
30MP0004859_abnormal_synaptic_plasticity1.15581235
31MP0002822_catalepsy1.11638184
32MP0002138_abnormal_hepatobiliary_system1.11208031
33MP0008995_early_reproductive_senescence1.10367549
34MP0001968_abnormal_touch/_nociception1.09559927
35MP0005248_abnormal_Harderian_gland1.07636589
36MP0003878_abnormal_ear_physiology1.04816987
37MP0005377_hearing/vestibular/ear_phenot1.04816987
38MP0003115_abnormal_respiratory_system1.03709400
39MP0001963_abnormal_hearing_physiology1.02088344
40MP0005395_other_phenotype1.01692907
41MP0000681_abnormal_thyroid_gland0.97622857
42MP0000026_abnormal_inner_ear0.94080854
43MP0001984_abnormal_olfaction0.89051302
44MP0000955_abnormal_spinal_cord0.87802546
45MP0005647_abnormal_sex_gland0.86841461
46MP0000049_abnormal_middle_ear0.85651248
47MP0001879_abnormal_lymphatic_vessel0.85407774
48MP0009046_muscle_twitch0.84463594
49MP0005666_abnormal_adipose_tissue0.79584663
50MP0005083_abnormal_biliary_tract0.74967252
51MP0005367_renal/urinary_system_phenotyp0.72359928
52MP0000516_abnormal_urinary_system0.72359928
53MP0005451_abnormal_body_composition0.70527966
54MP0005389_reproductive_system_phenotype0.70315475
55MP0002733_abnormal_thermal_nociception0.70026274
56MP0002067_abnormal_sensory_capabilities0.69782139
57MP0004085_abnormal_heartbeat0.68506463
58MP0003011_delayed_dark_adaptation0.64761717
59MP0002557_abnormal_social/conspecific_i0.64719624
60MP0000569_abnormal_digit_pigmentation0.63640767
61MP0004484_altered_response_of0.63153457
62MP0005636_abnormal_mineral_homeostasis0.63101199
63MP0003329_amyloid_beta_deposits0.59657836
64MP0001666_abnormal_nutrient_absorption0.59070249
65MP0000003_abnormal_adipose_tissue0.56983807
66MP0008058_abnormal_DNA_repair0.56786428
67MP0000613_abnormal_salivary_gland0.56085355
68MP0001905_abnormal_dopamine_level0.55876475
69MP0001324_abnormal_eye_pigmentation0.55796422
70MP0009278_abnormal_bone_marrow0.53699251
71MP0008961_abnormal_basal_metabolism0.53411230
72MP0001764_abnormal_homeostasis0.53115986
73MP0000358_abnormal_cell_content/0.52741426
74MP0003950_abnormal_plasma_membrane0.52409195
75MP0000249_abnormal_blood_vessel0.51599262
76MP0002928_abnormal_bile_duct0.51507321
77MP0003077_abnormal_cell_cycle0.49310380
78MP0002272_abnormal_nervous_system0.48440880
79MP0001293_anophthalmia0.48429407
80MP0005167_abnormal_blood-brain_barrier0.48303851
81MP0002572_abnormal_emotion/affect_behav0.47980612
82MP0003699_abnormal_female_reproductive0.47521000
83MP0003119_abnormal_digestive_system0.47464300
84MP0003137_abnormal_impulse_conducting0.46831235
85MP0009115_abnormal_fat_cell0.46763381
86MP0001970_abnormal_pain_threshold0.46728124
87MP0005423_abnormal_somatic_nervous0.45968378
88MP0002971_abnormal_brown_adipose0.45313900
89MP0000534_abnormal_ureter_morphology0.44946526
90MP0002734_abnormal_mechanical_nocicepti0.44570813
91MP0005397_hematopoietic_system_phenotyp0.44070858
92MP0001545_abnormal_hematopoietic_system0.44070858
93MP0010094_abnormal_chromosome_stability0.43597916
94MP0003879_abnormal_hair_cell0.43275457
95MP0002295_abnormal_pulmonary_circulatio0.43227919
96MP0000566_synostosis0.42114339
97MP0003880_abnormal_central_pattern0.42033757
98MP0004036_abnormal_muscle_relaxation0.41881045
99MP0002269_muscular_atrophy0.41499458
100MP0000470_abnormal_stomach_morphology0.41163591
101MP0003942_abnormal_urinary_system0.40869823
102MP0009697_abnormal_copulation0.40051573
103MP0009745_abnormal_behavioral_response0.38591823
104MP0001986_abnormal_taste_sensitivity0.38344530
105MP0005253_abnormal_eye_physiology0.38118657
106MP0006292_abnormal_olfactory_placode0.37859948
107MP0005375_adipose_tissue_phenotype0.37785653
108MP0001501_abnormal_sleep_pattern0.37656806
109MP0005535_abnormal_body_temperature0.37516231
110MP0005551_abnormal_eye_electrophysiolog0.37269454
111MP0003091_abnormal_cell_migration0.36810095
112MP0002234_abnormal_pharynx_morphology0.36675670
113MP0005408_hypopigmentation0.35849112
114MP0003936_abnormal_reproductive_system0.35239300
115MP0001270_distended_abdomen0.33503322
116MP0005166_decreased_susceptibility_to0.33297458
117MP0000467_abnormal_esophagus_morphology0.32823463
118MP0003045_fibrosis0.32722241
119MP0005084_abnormal_gallbladder_morpholo0.31405514
120MP0005391_vision/eye_phenotype0.31091830
121MP0003111_abnormal_nucleus_morphology0.30924421
122MP0000604_amyloidosis0.30095680
123MP0003786_premature_aging0.29971284
124MP0003633_abnormal_nervous_system0.29855422
125MP0001727_abnormal_embryo_implantation0.29313785
126MP0004742_abnormal_vestibular_system0.27628450
127MP0004130_abnormal_muscle_cell0.27420053
128MP0004811_abnormal_neuron_physiology0.26731661
129MP0000751_myopathy0.26516265
130MP0003948_abnormal_gas_homeostasis0.26226012
131MP0001661_extended_life_span0.25454511
132MP0002139_abnormal_hepatobiliary_system0.24858984
133MP0004270_analgesia0.24726929
134MP0001119_abnormal_female_reproductive0.24238059
135MP0003861_abnormal_nervous_system0.23777708
136MP0002796_impaired_skin_barrier0.23217415
137MP0002152_abnormal_brain_morphology0.23056776
138MP0003631_nervous_system_phenotype0.22895477
139MP0009672_abnormal_birth_weight0.22893469
140MP0003959_abnormal_lean_body0.22145842
141MP0004019_abnormal_vitamin_homeostasis0.21319444
142MP0002118_abnormal_lipid_homeostasis0.21026831
143MP0002102_abnormal_ear_morphology0.20725986
144MP0002736_abnormal_nociception_after0.20442308
145MP0010329_abnormal_lipoprotein_level0.20307216
146MP0005365_abnormal_bile_salt0.19401967
147MP0004043_abnormal_pH_regulation0.18724813
148MP0002092_abnormal_eye_morphology0.18644390
149MP0001849_ear_inflammation0.18624538
150MP0004808_abnormal_hematopoietic_stem0.17990968
151MP0002108_abnormal_muscle_morphology0.17835797
152MP0001730_embryonic_growth_arrest0.17726833
153MP0002169_no_abnormal_phenotype0.16828399
154MP0002873_normal_phenotype0.16602792
155MP0005334_abnormal_fat_pad0.15241500
156MP0006036_abnormal_mitochondrial_physio0.14992539
157MP0001440_abnormal_grooming_behavior0.14889314
158MP0002229_neurodegeneration0.14690461
159MP0002405_respiratory_system_inflammati0.14348737
160MP0008875_abnormal_xenobiotic_pharmacok0.14318082
161MP0008569_lethality_at_weaning0.14271522
162MP0004133_heterotaxia0.13808028

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.25989185
2Abnormal respiratory motile cilium morphology (HP:0005938)9.25989185
3Abnormal respiratory motile cilium physiology (HP:0012261)8.79409514
4Severe visual impairment (HP:0001141)8.71218209
5Rhinitis (HP:0012384)7.17483357
6Infertility (HP:0000789)6.99580680
7Abnormal ciliary motility (HP:0012262)6.88747595
8Chronic bronchitis (HP:0004469)6.78458706
9Nasal polyposis (HP:0100582)6.35871722
10Male infertility (HP:0003251)5.52702948
11Abnormality of the nasal mucosa (HP:0000433)5.25633154
12Bony spicule pigmentary retinopathy (HP:0007737)5.15688177
13Attenuation of retinal blood vessels (HP:0007843)5.12982747
14Bronchitis (HP:0012387)4.71831103
15Resting tremor (HP:0002322)4.65946421
16Hyperkalemia (HP:0002153)4.54857667
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.43339141
18Bronchiectasis (HP:0002110)4.39132185
19Nephronophthisis (HP:0000090)4.28638664
20Abnormal rod and cone electroretinograms (HP:0008323)4.27918064
21Chronic hepatic failure (HP:0100626)4.14703043
22Potter facies (HP:0002009)4.07545789
23Facial shape deformation (HP:0011334)4.07545789
24Abnormality of macular pigmentation (HP:0008002)4.04981155
25Hypoplastic ischia (HP:0003175)4.00420609
26Abnormal spermatogenesis (HP:0008669)3.93572141
27Unilateral renal agenesis (HP:0000122)3.65036329
28Enlarged epiphyses (HP:0010580)3.64524475
29Abnormality of the ischium (HP:0003174)3.55910088
30Aplasia/Hypoplasia of the earlobes (HP:0009906)3.50938508
31Cone-rod dystrophy (HP:0000548)3.50876075
32Recurrent otitis media (HP:0000403)3.39260370
33Recurrent bronchitis (HP:0002837)3.34079367
34Impulsivity (HP:0100710)3.33965194
35Congenital malformation of the right heart (HP:0011723)3.32197242
36Double outlet right ventricle (HP:0001719)3.32197242
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.24990109
38Recurrent sinusitis (HP:0011108)3.23250743
39Abnormality of the renal medulla (HP:0100957)3.23171205
40Hypoplasia of the thymus (HP:0000778)3.19866273
41Abnormality of the aortic arch (HP:0012303)3.13889676
42Progressive sensorineural hearing impairment (HP:0000408)2.98717996
43Postural instability (HP:0002172)2.97099967
44Tubulointerstitial nephritis (HP:0001970)2.94981691
45Gonadotropin excess (HP:0000837)2.85997731
46Generalized aminoaciduria (HP:0002909)2.80898629
47Hypoalphalipoproteinemia (HP:0003233)2.78256394
48Cholecystitis (HP:0001082)2.73601415
49Abnormal gallbladder physiology (HP:0012438)2.73601415
50Abnormality of the parathyroid morphology (HP:0011766)2.67799996
51Abnormality of potassium homeostasis (HP:0011042)2.64241687
52Spastic tetraparesis (HP:0001285)2.56773094
53Tubular atrophy (HP:0000092)2.56105678
54Amelogenesis imperfecta (HP:0000705)2.46901885
55Tubulointerstitial abnormality (HP:0001969)2.44706829
56Progressive cerebellar ataxia (HP:0002073)2.41750174
57Abnormality of the costochondral junction (HP:0000919)2.41054971
58Ventricular tachycardia (HP:0004756)2.38106848
59Abnormality of midbrain morphology (HP:0002418)2.36429857
60Molar tooth sign on MRI (HP:0002419)2.36429857
61Flattened epiphyses (HP:0003071)2.36058262
62Renovascular hypertension (HP:0100817)2.34088999
63Insulin-resistant diabetes mellitus (HP:0000831)2.33746873
64Dyschromatopsia (HP:0007641)2.30741121
65Tetany (HP:0001281)2.30086584
66Epiphyseal dysplasia (HP:0002656)2.29300133
67Menstrual irregularities (HP:0000858)2.28573618
68Heterotopia (HP:0002282)2.27858988
69Choroideremia (HP:0001139)2.26076610
70Portal hypertension (HP:0001409)2.26041097
71Azoospermia (HP:0000027)2.23759555
72Hyperthyroidism (HP:0000836)2.18012094
73Abnormality of dental color (HP:0011073)2.13461829
74Polyuria (HP:0000103)2.13027157
75Osteomalacia (HP:0002749)2.11012775
76Medial flaring of the eyebrow (HP:0010747)2.09629625
77Abnormality of the epiphysis of the femoral head (HP:0010574)2.09102697
78Hyponatremia (HP:0002902)2.09048530
79Abnormal ventriculo-arterial connection (HP:0011563)2.05981149
80Transposition of the great arteries (HP:0001669)2.05981149
81Abnormal connection of the cardiac segments (HP:0011545)2.05981149
82Abnormality of the hepatic vasculature (HP:0006707)2.05510942
83Abnormality of the pubic bones (HP:0003172)2.01930995
84Bell-shaped thorax (HP:0001591)2.01562894
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00355529
86Absent/shortened dynein arms (HP:0200106)13.7002930
87Dynein arm defect of respiratory motile cilia (HP:0012255)13.7002930
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5965214
89Decreased central vision (HP:0007663)1.97699956
90Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.95041335
91Abnormality of femoral epiphyses (HP:0006499)1.95041335
92Myokymia (HP:0002411)1.94127055
93Widely patent fontanelles and sutures (HP:0004492)1.94057982
94Hypoparathyroidism (HP:0000829)1.93974469
95Tubulointerstitial fibrosis (HP:0005576)1.91463675
96Atelectasis (HP:0100750)1.90612988
97Recurrent pneumonia (HP:0006532)1.90105162
98Hypophosphatemic rickets (HP:0004912)1.90101132
99Amblyopia (HP:0000646)1.89174661
100Hemorrhage of the eye (HP:0011885)1.88998549
101Flat capital femoral epiphysis (HP:0003370)1.88743810
102Progressive hearing impairment (HP:0001730)1.88507044
103Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86314737
104Abnormality of the femoral head (HP:0003368)1.85651889
105Bradycardia (HP:0001662)1.85497323
106Bowel incontinence (HP:0002607)1.84577385
107Neoplasm of the heart (HP:0100544)1.83709829
108Postaxial foot polydactyly (HP:0001830)1.83702336
109Recurrent corneal erosions (HP:0000495)1.81915140
110Hemiparesis (HP:0001269)1.81889366
111Focal segmental glomerulosclerosis (HP:0000097)1.81683461
112Stage 5 chronic kidney disease (HP:0003774)1.80693798
113Short ribs (HP:0000773)1.74224668
114Bile duct proliferation (HP:0001408)1.71435679
115Abnormal biliary tract physiology (HP:0012439)1.71435679
116Polydipsia (HP:0001959)1.71070468
117Abnormal drinking behavior (HP:0030082)1.71070468
118Abnormality of the lower motor neuron (HP:0002366)1.66890307
119Congenital hepatic fibrosis (HP:0002612)1.66711407
120Neurofibrillary tangles (HP:0002185)1.65578790
121Abnormality of the renal cortex (HP:0011035)1.60515773
122Oculomotor apraxia (HP:0000657)1.53773724
123Abnormality of dentin (HP:0010299)1.53044028
124Asymmetric septal hypertrophy (HP:0001670)1.52989563
125Decreased electroretinogram (ERG) amplitude (HP:0000654)1.52701444
126Abnormality of renal excretion (HP:0011036)1.52020721
127Deformed sella turcica (HP:0002681)1.51848666
128Renal dysplasia (HP:0000110)1.47758870
129Absent epiphyses (HP:0010577)1.46221987
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.46221987
131Absent frontal sinuses (HP:0002688)1.45968296
132Cerebral inclusion bodies (HP:0100314)1.44033585
133Fibular hypoplasia (HP:0003038)1.43922118
134Abnormality of the dental root (HP:0006486)1.43085542
135Taurodontia (HP:0000679)1.43085542
136Abnormality of permanent molar morphology (HP:0011071)1.43085542
137Hypercholesterolemia (HP:0003124)1.39456845
138Bundle branch block (HP:0011710)1.39003293
139Postaxial hand polydactyly (HP:0001162)1.38612776
140J-shaped sella turcica (HP:0002680)1.38329019
141Amyotrophic lateral sclerosis (HP:0007354)1.36893771
142Abnormality of molar morphology (HP:0011070)1.34530625
143Abnormality of molar (HP:0011077)1.34530625
144Short thorax (HP:0010306)1.33997806
145Facial cleft (HP:0002006)1.33587012
146Truncal obesity (HP:0001956)1.32735388
147Abnormality of the dental pulp (HP:0006479)1.30098707
148Abnormal urine output (HP:0012590)1.29730504
149Broad distal phalanx of finger (HP:0009836)1.29544342
150Aplasia/Hypoplasia of the lens (HP:0008063)1.28650271
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.28153058
152Nephropathy (HP:0000112)1.25742200
153Lissencephaly (HP:0001339)1.25665159
154Pachygyria (HP:0001302)1.25463726
155Cystic liver disease (HP:0006706)1.25444261
156Chronic sinusitis (HP:0011109)1.25166026
157Loss of speech (HP:0002371)1.24656126
158Impaired proprioception (HP:0010831)1.24562238
159Glucose intolerance (HP:0000833)1.24270660
160Microglossia (HP:0000171)1.22443749
161Hyporeflexia of lower limbs (HP:0002600)1.21723105
162Polymicrogyria (HP:0002126)1.16407058
163Short femoral neck (HP:0100864)1.14000150
164Cerebellar dysplasia (HP:0007033)1.13479407
165Abnormality of the sella turcica (HP:0002679)1.11036859
166Easy fatigability (HP:0003388)1.10708896
167Median cleft lip (HP:0000161)1.10441095
168Supernumerary spleens (HP:0009799)1.10353003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.53162628
2PDK47.53162628
3PRKD36.99590461
4TESK16.38011339
5DDR25.24543792
6PDK24.94009952
7ICK4.80241861
8MAP4K23.80419098
9INSRR3.46802826
10BRD42.78314829
11PLK22.77271445
12PNCK2.61011156
13PTK2B2.21249020
14WNK41.98806363
15STK391.79333845
16MST1R1.78511311
17DYRK1B1.73643207
18STK381.71042689
19PIK3CG1.42996537
20NEK21.40706130
21CDK71.35245944
22KSR21.20692583
23MAP3K91.12265117
24MAPK151.01626746
25CAMK1G0.98429604
26TYRO30.98383383
27PDK10.97041648
28AKT30.92403908
29WNK10.86634001
30CAMK1D0.84460135
31LATS20.84190104
32UHMK10.82601515
33BRAF0.75980050
34MAP3K20.75750370
35DYRK30.75705939
36MAP3K110.73468296
37RPS6KA20.72221339
38PASK0.71702505
39MAP2K20.70881720
40SIK20.68658135
41PRKG20.68046284
42TESK20.64722975
43MAP3K80.64655043
44PRKAA20.63723280
45STK30.63526613
46MAP2K60.60320097
47ROCK10.59503069
48RIPK40.57881746
49PDPK10.53966048
50EEF2K0.53343130
51TTK0.51884688
52CHEK20.47899750
53SGK2230.47532249
54SGK4940.47532249
55PAK10.47205103
56IRAK10.46700744
57LATS10.45981293
58CDK30.45263087
59LMTK20.45165562
60CCNB10.42547944
61PAK20.42038120
62MTOR0.39630680
63CHEK10.38537443
64RPS6KC10.38201710
65RPS6KL10.38201710
66CAMK40.36934700
67RPS6KA60.35448335
68ARAF0.35207571
69PINK10.34592484
70NEK60.34442491
71NTRK20.32990160
72PAK40.32341732
73MARK10.31805279
74SGK10.29847485
75MARK20.28707056
76NTRK30.27772927
77ATM0.27622854
78CDK120.27112393
79IRAK20.26058346
80MAPK140.25015027
81CAMKK10.24782014
82MET0.23891080
83MAPK100.23688588
84STK38L0.23010559
85PRKAA10.21913726
86PRKCG0.21755439
87ATR0.21712893
88MAPKAPK50.20765458
89MUSK0.19773859
90FER0.18346793
91WEE10.18105546
92AKT10.17163651
93CDC70.14937771
94MAP3K100.14490438
95MAPK110.14439577
96TIE10.14429167
97RPS6KB10.13683863
98BRSK10.13415902
99CSNK1D0.12770231
100MINK10.12424243
101MAP3K40.12417895
102ACVR1B0.12356511
103BLK0.11924295
104EPHB10.11888915
105CDK60.11627029
106PLK40.11218071
107STK110.09557254
108PRKCZ0.09440156
109OXSR10.09247728
110MAPK90.08244293
111PRKACA0.07931268
112IKBKB0.07743314
113TAOK10.07538587
114GSK3B0.07408963
115TRIB30.07268063
116TNIK0.07032034
117PLK10.06699544
118BMPR1B0.06640877
119RPS6KA10.05980427
120CHUK0.05629380
121SGK20.05531824
122PRKCQ0.04865024
123MAP3K70.04781937
124RIPK10.04328696
125CDK40.03841239
126CDK150.03782116
127EGFR0.03383796
128CDK20.03158810
129PKN10.02672636
130MAP3K10.02663984
131PAK60.02323454
132CAMK2A0.02002474
133CDK10.01994234
134PRKG10.01724855
135ZAP700.01677070
136CDK180.01392373
137CSNK2A10.01105851
138CLK10.01089659
139CDK11A0.00926429
140CAMK10.00469856
141MAPK80.00166148
142PRKACG0.00026471
143PRKCD-0.0344311
144PRKCA-0.0283530
145WNK3-0.0279318
146PDGFRB-0.0239354
147PRKDC-0.0188650
148CDK14-0.0176366
149CSK-0.0132502
150SRC-0.0131670
151PRKACB-0.0128438
152STK10-0.0099993
153CSNK2A2-0.0097962
154RPS6KA3-0.0096992
155MAPK1-0.0040337
156PRKCB-0.0008791

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.44152610
2Fatty acid biosynthesis_Homo sapiens_hsa000614.59346653
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.39720931
4Pyruvate metabolism_Homo sapiens_hsa006203.32728412
5Olfactory transduction_Homo sapiens_hsa047403.31329575
6Vitamin B6 metabolism_Homo sapiens_hsa007503.11477804
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.03643087
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.78614514
9Butanoate metabolism_Homo sapiens_hsa006502.76382585
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.76054879
11Linoleic acid metabolism_Homo sapiens_hsa005912.62759556
12Propanoate metabolism_Homo sapiens_hsa006402.56388691
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.55317962
14Glucagon signaling pathway_Homo sapiens_hsa049222.46009178
15Dorso-ventral axis formation_Homo sapiens_hsa043202.44592984
16PPAR signaling pathway_Homo sapiens_hsa033202.15299900
17Glycerolipid metabolism_Homo sapiens_hsa005612.15203865
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13501991
19Selenocompound metabolism_Homo sapiens_hsa004501.99176721
20Type I diabetes mellitus_Homo sapiens_hsa049401.82084678
21Allograft rejection_Homo sapiens_hsa053301.82004186
22Autoimmune thyroid disease_Homo sapiens_hsa053201.76139652
23Fructose and mannose metabolism_Homo sapiens_hsa000511.76063617
24Basal transcription factors_Homo sapiens_hsa030221.74102908
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71711257
26Oocyte meiosis_Homo sapiens_hsa041141.68275031
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.68209054
28Graft-versus-host disease_Homo sapiens_hsa053321.66291794
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.64228378
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62847642
31Fatty acid metabolism_Homo sapiens_hsa012121.61607404
32Fatty acid degradation_Homo sapiens_hsa000711.58457267
33Phenylalanine metabolism_Homo sapiens_hsa003601.52802451
34Mineral absorption_Homo sapiens_hsa049781.43098296
35Amphetamine addiction_Homo sapiens_hsa050311.40764933
36Arginine and proline metabolism_Homo sapiens_hsa003301.33991203
37Antigen processing and presentation_Homo sapiens_hsa046121.31871888
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.31495569
39Pentose phosphate pathway_Homo sapiens_hsa000301.29039198
40Viral myocarditis_Homo sapiens_hsa054161.28688254
41Carbon metabolism_Homo sapiens_hsa012001.25651377
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22293195
43Ether lipid metabolism_Homo sapiens_hsa005651.20986198
44Fat digestion and absorption_Homo sapiens_hsa049751.19457345
45Fanconi anemia pathway_Homo sapiens_hsa034601.16471119
46Renin secretion_Homo sapiens_hsa049241.15368920
47RNA transport_Homo sapiens_hsa030131.12973819
48Cardiac muscle contraction_Homo sapiens_hsa042601.08241906
49mRNA surveillance pathway_Homo sapiens_hsa030151.08227405
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.07049075
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.97003164
52Phototransduction_Homo sapiens_hsa047440.94271211
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92403518
54Huntingtons disease_Homo sapiens_hsa050160.90248518
55Arginine biosynthesis_Homo sapiens_hsa002200.87627577
56Hedgehog signaling pathway_Homo sapiens_hsa043400.87336737
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85824189
58Bile secretion_Homo sapiens_hsa049760.84675970
59Morphine addiction_Homo sapiens_hsa050320.84667489
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82796372
61Estrogen signaling pathway_Homo sapiens_hsa049150.82509958
62Purine metabolism_Homo sapiens_hsa002300.81398822
63Insulin secretion_Homo sapiens_hsa049110.80389181
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78461093
65Influenza A_Homo sapiens_hsa051640.75852865
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75504643
67Thyroid hormone synthesis_Homo sapiens_hsa049180.74558627
68Biosynthesis of amino acids_Homo sapiens_hsa012300.74476190
69ABC transporters_Homo sapiens_hsa020100.74254550
70Legionellosis_Homo sapiens_hsa051340.72509348
71Long-term potentiation_Homo sapiens_hsa047200.71492648
72Collecting duct acid secretion_Homo sapiens_hsa049660.65840926
73Tyrosine metabolism_Homo sapiens_hsa003500.65394302
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.65321014
75Arachidonic acid metabolism_Homo sapiens_hsa005900.65224704
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64806292
77Protein digestion and absorption_Homo sapiens_hsa049740.63448154
78Chemical carcinogenesis_Homo sapiens_hsa052040.63210880
79Glutathione metabolism_Homo sapiens_hsa004800.60901970
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59404303
81Taste transduction_Homo sapiens_hsa047420.58627351
82Salivary secretion_Homo sapiens_hsa049700.58189680
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57680822
84Calcium signaling pathway_Homo sapiens_hsa040200.57480616
85Endocytosis_Homo sapiens_hsa041440.55754551
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55612001
87Nicotine addiction_Homo sapiens_hsa050330.54714056
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53361352
89Retinol metabolism_Homo sapiens_hsa008300.51454322
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48942525
91Renin-angiotensin system_Homo sapiens_hsa046140.48747012
92MAPK signaling pathway_Homo sapiens_hsa040100.48671920
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48590536
94Inositol phosphate metabolism_Homo sapiens_hsa005620.48208417
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48147431
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48145430
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48041364
98Gastric acid secretion_Homo sapiens_hsa049710.47976136
99AMPK signaling pathway_Homo sapiens_hsa041520.47809105
100Tight junction_Homo sapiens_hsa045300.47365841
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.47014966
102Pancreatic secretion_Homo sapiens_hsa049720.46937437
103Glutamatergic synapse_Homo sapiens_hsa047240.46921032
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.46613846
105Synaptic vesicle cycle_Homo sapiens_hsa047210.46025917
106Acute myeloid leukemia_Homo sapiens_hsa052210.45387366
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44527901
108Circadian entrainment_Homo sapiens_hsa047130.44495171
109Viral carcinogenesis_Homo sapiens_hsa052030.37893115
110cAMP signaling pathway_Homo sapiens_hsa040240.36453020
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.35932314
112Serotonergic synapse_Homo sapiens_hsa047260.33841602
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33825261
114Cholinergic synapse_Homo sapiens_hsa047250.33517464
115VEGF signaling pathway_Homo sapiens_hsa043700.32632709
116Metabolic pathways_Homo sapiens_hsa011000.27399871
117Sulfur metabolism_Homo sapiens_hsa009200.25522885
118Systemic lupus erythematosus_Homo sapiens_hsa053220.25134929
119Cocaine addiction_Homo sapiens_hsa050300.25057874
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.25029241
121GABAergic synapse_Homo sapiens_hsa047270.24614641
122Basal cell carcinoma_Homo sapiens_hsa052170.24444676
123Oxytocin signaling pathway_Homo sapiens_hsa049210.21099906
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20851330
125Prolactin signaling pathway_Homo sapiens_hsa049170.20043074
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.19936116
127Type II diabetes mellitus_Homo sapiens_hsa049300.19570623
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18626589
129Herpes simplex infection_Homo sapiens_hsa051680.18426380
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16879471
131N-Glycan biosynthesis_Homo sapiens_hsa005100.15949690
132Alcoholism_Homo sapiens_hsa050340.15334947
133Adherens junction_Homo sapiens_hsa045200.14262381
134Insulin resistance_Homo sapiens_hsa049310.14086768
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13257473
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13037610
137ECM-receptor interaction_Homo sapiens_hsa045120.12762724
138Nitrogen metabolism_Homo sapiens_hsa009100.12011361
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11904195
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11216476
141Complement and coagulation cascades_Homo sapiens_hsa046100.11086774
142HIF-1 signaling pathway_Homo sapiens_hsa040660.10073419
143Toxoplasmosis_Homo sapiens_hsa051450.08793390

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