PRR32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.83619577
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)9.38908961
3sarcoplasmic reticulum calcium ion transport (GO:0070296)8.43222799
4negative regulation of potassium ion transmembrane transport (GO:1901380)8.38991086
5sarcomere organization (GO:0045214)8.13179153
6actin filament-based movement (GO:0030048)8.10735119
7positive regulation of myotube differentiation (GO:0010831)7.60506442
8striated muscle contraction (GO:0006941)7.30074417
9response to inactivity (GO:0014854)6.45218937
10myofibril assembly (GO:0030239)6.23419290
11actomyosin structure organization (GO:0031032)6.20511504
12glycerophospholipid catabolic process (GO:0046475)5.89780239
13positive regulation of myoblast differentiation (GO:0045663)5.83592868
14negative regulation of protein localization to cell surface (GO:2000009)5.75217345
15spliceosomal tri-snRNP complex assembly (GO:0000244)5.57730070
16regulation of sequestering of triglyceride (GO:0010889)5.57072447
17neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.51561913
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.35641973
19response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.31938302
20histone H2A ubiquitination (GO:0033522)5.31437409
21skeletal muscle fiber development (GO:0048741)5.24347825
22myotube cell development (GO:0014904)5.12445542
23positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.11829725
24muscle cell fate commitment (GO:0042693)5.10475966
25plasma membrane repair (GO:0001778)5.08246044
26sodium-independent organic anion transport (GO:0043252)5.00158648
27regulation of sarcomere organization (GO:0060297)4.97910301
28type B pancreatic cell development (GO:0003323)4.97495461
29muscle organ development (GO:0007517)4.92756328
30regulation of cell communication by electrical coupling (GO:0010649)4.89370669
31muscle contraction (GO:0006936)4.85732985
32muscle structure development (GO:0061061)4.85564129
33regulation of skeletal muscle cell differentiation (GO:2001014)4.80448419
34chaperone-mediated protein transport (GO:0072321)4.76240016
35striated muscle atrophy (GO:0014891)4.71654006
36regulation of female gonad development (GO:2000194)4.68425913
37regulation of myoblast differentiation (GO:0045661)4.62772737
38skeletal muscle tissue development (GO:0007519)4.59392742
39male meiosis I (GO:0007141)4.54610445
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.47993209
41negative regulation of fatty acid transport (GO:2000192)4.47369935
42parturition (GO:0007567)4.43278569
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.40189504
44regulation of relaxation of muscle (GO:1901077)4.39586778
45retinol metabolic process (GO:0042572)4.39235335
46muscle system process (GO:0003012)4.33528334
47low-density lipoprotein particle clearance (GO:0034383)4.32076654
48negative regulation of norepinephrine secretion (GO:0010700)4.32044979
49white fat cell differentiation (GO:0050872)4.31927926
50muscle cell cellular homeostasis (GO:0046716)4.28530979
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.26495983
52mitochondrion distribution (GO:0048311)4.26244352
53skeletal muscle tissue regeneration (GO:0043403)4.22163670
54brown fat cell differentiation (GO:0050873)4.20124999
55positive regulation of glomerulus development (GO:0090193)4.18251318
56glycerolipid catabolic process (GO:0046503)4.17537529
57piRNA metabolic process (GO:0034587)4.16499191
58cardiac myofibril assembly (GO:0055003)4.14057844
59regulation of meiosis (GO:0040020)4.10522727
60meiosis I (GO:0007127)4.03524910
61response to parathyroid hormone (GO:0071107)4.03061235
62regulation of myotube differentiation (GO:0010830)4.02904210
63response to caffeine (GO:0031000)4.02594675
64muscle atrophy (GO:0014889)4.01577695
65response to muscle activity (GO:0014850)4.00224954
66regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.98124647
67G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.97057526
68RNA localization (GO:0006403)3.91649134
69regulation of pseudopodium assembly (GO:0031272)3.88737013
70keratan sulfate catabolic process (GO:0042340)3.87781144
71regulation of skeletal muscle fiber development (GO:0048742)3.82436309
72negative regulation of potassium ion transport (GO:0043267)3.82207921
73cardiac muscle contraction (GO:0060048)3.78194225
74positive regulation of skeletal muscle tissue development (GO:0048643)3.78053143
75regulation of meiosis I (GO:0060631)3.77984742
76regulation of striated muscle contraction (GO:0006942)3.74532512
77positive regulation of uterine smooth muscle contraction (GO:0070474)3.73734955
78regulation of transforming growth factor beta2 production (GO:0032909)3.72431235
79female gamete generation (GO:0007292)3.71430601
80ovulation from ovarian follicle (GO:0001542)3.71249230
81negative regulation of cell size (GO:0045792)3.69247952
82positive regulation of striated muscle cell differentiation (GO:0051155)3.66275678
83notochord development (GO:0030903)3.64968703
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.64819227
85triglyceride catabolic process (GO:0019433)3.63448904
86extracellular fibril organization (GO:0043206)3.62680660
87histone H2A monoubiquitination (GO:0035518)3.61545060
88negative regulation of hormone biosynthetic process (GO:0032353)3.60136226
89negative regulation of hormone metabolic process (GO:0032351)3.60136226
90regulation of potassium ion transmembrane transporter activity (GO:1901016)3.59704544
91meiotic cell cycle (GO:0051321)3.58626403
92biotin metabolic process (GO:0006768)3.57287170
93DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.57272313
94negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.54036969
95muscle fiber development (GO:0048747)3.52535711
96regulation of cAMP-dependent protein kinase activity (GO:2000479)3.51966388
97mitotic metaphase plate congression (GO:0007080)3.50731036
98male meiosis (GO:0007140)3.50079908
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.49584552
100triglyceride biosynthetic process (GO:0019432)3.42679134
101regulation of exit from mitosis (GO:0007096)3.42346226
102paraxial mesoderm development (GO:0048339)3.40015885
103CDP-diacylglycerol biosynthetic process (GO:0016024)3.39683000
104musculoskeletal movement (GO:0050881)3.38870611
105multicellular organismal movement (GO:0050879)3.38870611
106acylglycerol biosynthetic process (GO:0046463)3.37831895
107neutral lipid biosynthetic process (GO:0046460)3.37831895
108tachykinin receptor signaling pathway (GO:0007217)3.37794747
109positive regulation of fatty acid oxidation (GO:0046321)3.37154347
110myotube differentiation (GO:0014902)3.36919265
111DNA damage response, signal transduction resulting in transcription (GO:0042772)3.35844529
112regulation of integrin-mediated signaling pathway (GO:2001044)3.35404693
113striated muscle tissue development (GO:0014706)3.34017475
114positive regulation of cellular response to insulin stimulus (GO:1900078)3.32663637
115vitamin transmembrane transport (GO:0035461)3.31941538
116dopamine biosynthetic process (GO:0042416)3.31820874
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30870225
118regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.29998122
119positive regulation of Cdc42 GTPase activity (GO:0043089)3.29921966
120negative regulation of meiosis (GO:0045835)3.28471066
121regulation of calcium ion transmembrane transport (GO:1903169)3.27956860
122regulation of calcium ion transmembrane transporter activity (GO:1901019)3.27956860
123regulation of muscle system process (GO:0090257)3.26823262
124positive regulation of insulin receptor signaling pathway (GO:0046628)3.26591918
125negative regulation of muscle hypertrophy (GO:0014741)3.25781951
126striated muscle cell development (GO:0055002)3.23827238
127acylglycerol catabolic process (GO:0046464)3.22576595
128neutral lipid catabolic process (GO:0046461)3.22576595
129myoblast fusion (GO:0007520)3.21089572
130cardiac muscle cell development (GO:0055013)3.20774175
131glandular epithelial cell development (GO:0002068)3.19585159
132endocrine hormone secretion (GO:0060986)3.18682735
133regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.15348976
134regulation of membrane repolarization (GO:0060306)3.15020677
135regulation of muscle contraction (GO:0006937)3.14044874
136DNA damage induced protein phosphorylation (GO:0006975)3.12253163
137CDP-diacylglycerol metabolic process (GO:0046341)3.12159357
138myoblast migration (GO:0051451)3.10379111
139regulation of meiotic cell cycle (GO:0051445)3.10185952
140face morphogenesis (GO:0060325)3.09734695
141negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.09702131
142regulation of mitotic spindle organization (GO:0060236)3.09164247
143lipid storage (GO:0019915)3.09152360
144cardiac cell development (GO:0055006)3.09016654
145protein localization to endosome (GO:0036010)3.08549909
146negative regulation of heart rate (GO:0010459)3.07102737
147positive regulation of protein depolymerization (GO:1901881)3.04356742
148cell-cell junction maintenance (GO:0045217)3.02029399
149microtubule severing (GO:0051013)3.01840495
150primary alcohol metabolic process (GO:0034308)3.01614768
151negative regulation of TOR signaling (GO:0032007)3.01137927
152positive regulation of phosphatase activity (GO:0010922)3.01077663
153regulation of glucocorticoid metabolic process (GO:0031943)3.00468577
154peroxisome fission (GO:0016559)3.00329514
155negative regulation of cardiac muscle hypertrophy (GO:0010614)2.99326189
156regulation of uterine smooth muscle contraction (GO:0070472)2.98250340
157muscle tissue development (GO:0060537)2.96887594
158lung epithelium development (GO:0060428)2.96804011
159monoubiquitinated protein deubiquitination (GO:0035520)2.96511053
160regulation of potassium ion transmembrane transport (GO:1901379)2.95855878
161muscle cell development (GO:0055001)2.93722108
162protein localization to cell surface (GO:0034394)2.91901982
163regulation of histone H3-K27 methylation (GO:0061085)2.89051937
164growth hormone receptor signaling pathway (GO:0060396)2.88479946
165positive regulation of fatty acid beta-oxidation (GO:0032000)2.88417233
166oocyte maturation (GO:0001556)2.88045286
167positive regulation of protein homodimerization activity (GO:0090073)2.87455077
168negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87116062
169negative regulation of calcium ion transmembrane transport (GO:1903170)2.87116062
170fibril organization (GO:0097435)2.86813064
171adult feeding behavior (GO:0008343)2.83985374
172regulation of retinoic acid receptor signaling pathway (GO:0048385)2.83003320
173mitotic chromosome condensation (GO:0007076)2.82879763
174regulation of mononuclear cell migration (GO:0071675)2.82309146
175tongue development (GO:0043586)2.80368862
176attachment of spindle microtubules to kinetochore (GO:0008608)2.77340103
177regulation of macrophage chemotaxis (GO:0010758)2.77158384
178metaphase plate congression (GO:0051310)2.76691906
179cytoplasmic mRNA processing body assembly (GO:0033962)2.76593092
180fatty acid transmembrane transport (GO:1902001)2.75958168
181retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74828898
182female gonad development (GO:0008585)2.73610765
183negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.73503824
184axonemal dynein complex assembly (GO:0070286)2.72187655
185response to dietary excess (GO:0002021)2.72042774
186potassium ion export (GO:0071435)2.71860019
187cell junction maintenance (GO:0034331)2.70998309
188positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63080725
189regulation of fatty acid oxidation (GO:0046320)2.62605311
190folic acid transport (GO:0015884)2.62544811
191regulation of spindle organization (GO:0090224)2.62373091
192glycerol metabolic process (GO:0006071)2.62263292
193female genitalia development (GO:0030540)2.58988473
194synaptonemal complex assembly (GO:0007130)2.58896781
195negative regulation of smooth muscle cell differentiation (GO:0051151)2.58808203
196positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.58645154
197skeletal muscle contraction (GO:0003009)13.4638029
198actin-myosin filament sliding (GO:0033275)13.0330433
199muscle filament sliding (GO:0030049)13.0330433
200actin-mediated cell contraction (GO:0070252)10.8216323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.79123582
2SMAD_19615063_ChIP-ChIP_OVARY_Human6.16930265
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.15416950
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.94263059
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.47974185
6IGF1R_20145208_ChIP-Seq_DFB_Human3.13942081
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.13269546
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.03995564
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.45106954
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32572879
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30276119
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.22257549
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18919691
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.18243281
15PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.13469548
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09186384
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05320228
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99950138
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94161205
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.85291672
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85240327
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78887469
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78887469
24ZNF263_19887448_ChIP-Seq_K562_Human1.78831030
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78361391
26PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.78087527
27AR_21909140_ChIP-Seq_LNCAP_Human1.77332061
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77235752
29FUS_26573619_Chip-Seq_HEK293_Human1.73067043
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.72884622
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64212747
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63283343
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.61853459
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60549588
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.59848905
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.58830697
37CJUN_26792858_Chip-Seq_BT549_Human1.58469148
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.57465306
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56193895
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55307577
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55287505
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55285044
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54504839
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.53493159
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53372184
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52977227
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50536258
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47879376
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.45958934
50DROSHA_22980978_ChIP-Seq_HELA_Human1.44549933
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44309423
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.42210705
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41473312
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40634361
55LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37591351
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37100565
57STAT3_23295773_ChIP-Seq_U87_Human1.35473985
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33877936
59BCAT_22108803_ChIP-Seq_LS180_Human1.32443864
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.32077170
61LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31121481
62GBX2_23144817_ChIP-Seq_PC3_Human1.30402945
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30301090
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28865705
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27944082
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27793393
67PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.27601746
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26899045
69SMAD4_21799915_ChIP-Seq_A2780_Human1.26844213
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25034121
71CDX2_22108803_ChIP-Seq_LS180_Human1.24927294
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22409287
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22159627
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20754279
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20668201
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19659251
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19351817
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15976333
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14934251
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13274007
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13135217
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11886494
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10974923
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.10532226
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09077159
86TP53_16413492_ChIP-PET_HCT116_Human1.07941071
87AR_25329375_ChIP-Seq_VCAP_Human1.07800066
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.07604755
89CLOCK_20551151_ChIP-Seq_293T_Human1.07162255
90KDM2B_26808549_Chip-Seq_REH_Human1.06892528
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06216160
92EZH2_22144423_ChIP-Seq_EOC_Human1.06008576
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05186521
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05125537
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05104846
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.04695711
97RXR_22108803_ChIP-Seq_LS180_Human1.03973270
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03631032
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03626671
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02261435
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.02205617
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.01189616
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.01097825
104ERG_20517297_ChIP-Seq_VCAP_Human1.00669973
105TP63_23658742_ChIP-Seq_EP156T_Human0.99703230
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99668877
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.99566958
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99411394
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98845429
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98746448
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97300894
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96742945
113CRX_20693478_ChIP-Seq_RETINA_Mouse0.96537495
114STAT1_17558387_ChIP-Seq_HELA_Human0.95604476
115TP53_20018659_ChIP-ChIP_R1E_Mouse0.95455124
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95414114
117TBL1_22424771_ChIP-Seq_293T_Human0.95202232
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94824761
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94422378
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93704139
121OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93252500
122VDR_22108803_ChIP-Seq_LS180_Human0.92509098
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91741680
124VDR_24787735_ChIP-Seq_THP-1_Human0.90924777
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.90845044
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90350308
127TP53_18474530_ChIP-ChIP_U2OS_Human0.90264654
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.90096503
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90095585
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89886310
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89779755
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89420870
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89137511
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.88972308
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88269245
136SMRT_27268052_Chip-Seq_Bcells_Human0.87620929
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87412829
138P53_22387025_ChIP-Seq_ESCs_Mouse0.87358264
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87317422
140FOXA2_19822575_ChIP-Seq_HepG2_Human0.87293455
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86749803
142FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86343812
143AR_21572438_ChIP-Seq_LNCaP_Human0.86015120
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.85329744
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.85329744
146BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84876253
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84543585
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84543585
149CTCF_27219007_Chip-Seq_Bcells_Human0.84254458
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83804884
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83517914
152ZFX_18555785_Chip-Seq_ESCs_Mouse0.83350894
153SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83196234
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83195642
155TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82936169
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.82931220
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.82429977
158PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82377061
159TCF4_23295773_ChIP-Seq_U87_Human0.82284946
160E2F1_18555785_Chip-Seq_ESCs_Mouse0.81906000
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81883971
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81502464
163AR_19668381_ChIP-Seq_PC3_Human0.81262136
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.81088514
165SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80474131
166OCT4_18555785_Chip-Seq_ESCs_Mouse0.79976305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.49970238
2MP0005666_abnormal_adipose_tissue5.26053826
3MP0005670_abnormal_white_adipose4.83392586
4MP0003646_muscle_fatigue4.13964663
5MP0004185_abnormal_adipocyte_glucose3.50370946
6MP0005375_adipose_tissue_phenotype3.38123571
7MP0005451_abnormal_body_composition3.34314521
8MP0003122_maternal_imprinting3.18254906
9MP0002971_abnormal_brown_adipose3.09587608
10MP0000013_abnormal_adipose_tissue2.92362337
11MP0001958_emphysema2.90239017
12MP0004036_abnormal_muscle_relaxation2.90232105
13MP0004084_abnormal_cardiac_muscle2.84440866
14MP0000747_muscle_weakness2.83001154
15MP0008438_abnormal_cutaneous_collagen2.73355506
16MP0008004_abnormal_stomach_pH2.70606749
17MP0002269_muscular_atrophy2.62660909
18MP0004130_abnormal_muscle_cell2.48328231
19MP0002653_abnormal_ependyma_morphology2.45414850
20MP0005503_abnormal_tendon_morphology2.42475294
21MP0002837_dystrophic_cardiac_calcinosis2.34599921
22MP0003718_maternal_effect2.30360756
23MP0009115_abnormal_fat_cell2.12107256
24MP0005395_other_phenotype2.09503230
25MP0000003_abnormal_adipose_tissue2.07607587
26MP0003186_abnormal_redox_activity2.04748908
27MP0002876_abnormal_thyroid_physiology2.02552339
28MP0002102_abnormal_ear_morphology2.01021504
29MP0002168_other_aberrant_phenotype1.97712474
30MP0005646_abnormal_pituitary_gland1.90224526
31MP0002970_abnormal_white_adipose1.87121239
32MP0009384_cardiac_valve_regurgitation1.79507233
33MP0002163_abnormal_gland_morphology1.77359064
34MP0003705_abnormal_hypodermis_morpholog1.65212500
35MP0004019_abnormal_vitamin_homeostasis1.63838685
36MP0005275_abnormal_skin_tensile1.51984103
37MP0006276_abnormal_autonomic_nervous1.46335332
38MP0005535_abnormal_body_temperature1.41424395
39MP0002249_abnormal_larynx_morphology1.38853678
40MP0001542_abnormal_bone_strength1.35542843
41MP0003950_abnormal_plasma_membrane1.34914066
42MP0003121_genomic_imprinting1.30665446
43MP0002332_abnormal_exercise_endurance1.26908362
44MP0005408_hypopigmentation1.25530839
45MP0005334_abnormal_fat_pad1.24477679
46MP0003699_abnormal_female_reproductive1.22415580
47MP0010329_abnormal_lipoprotein_level1.20255008
48MP0001929_abnormal_gametogenesis1.19470346
49MP0004272_abnormal_basement_membrane1.19146608
50MP0001119_abnormal_female_reproductive1.19123929
51MP0009780_abnormal_chondrocyte_physiolo1.15741255
52MP0010368_abnormal_lymphatic_system1.13406665
53MP0002108_abnormal_muscle_morphology1.11137214
54MP0005620_abnormal_muscle_contractility1.09245418
55MP0003123_paternal_imprinting1.07787469
56MP0006138_congestive_heart_failure1.05586772
57MP0001915_intracranial_hemorrhage1.05444750
58MP0004087_abnormal_muscle_fiber1.02931273
59MP0010030_abnormal_orbit_morphology1.01879397
60MP0005379_endocrine/exocrine_gland_phen1.01361665
61MP0000534_abnormal_ureter_morphology1.00712580
62MP0000653_abnormal_sex_gland0.99937160
63MP0003329_amyloid_beta_deposits0.99426431
64MP0004134_abnormal_chest_morphology0.97730978
65MP0005595_abnormal_vascular_smooth0.91803327
66MP0000751_myopathy0.91371532
67MP0003879_abnormal_hair_cell0.90169904
68MP0008877_abnormal_DNA_methylation0.89071104
69MP0001346_abnormal_lacrimal_gland0.87428847
70MP0000767_abnormal_smooth_muscle0.87175087
71MP0004484_altered_response_of0.85499107
72MP0005330_cardiomyopathy0.84348012
73MP0003045_fibrosis0.84139936
74MP0005623_abnormal_meninges_morphology0.82473013
75MP0004215_abnormal_myocardial_fiber0.81652881
76MP0005452_abnormal_adipose_tissue0.78658758
77MP0002060_abnormal_skin_morphology0.78229499
78MP0000750_abnormal_muscle_regeneration0.78118904
79MP0002078_abnormal_glucose_homeostasis0.77421947
80MP0002118_abnormal_lipid_homeostasis0.77297182
81MP0001944_abnormal_pancreas_morphology0.77117115
82MP0000733_abnormal_muscle_development0.76255334
83MP0004145_abnormal_muscle_electrophysio0.75390870
84MP0003690_abnormal_glial_cell0.75223266
85MP0002295_abnormal_pulmonary_circulatio0.74790819
86MP0005647_abnormal_sex_gland0.74589442
87MP0004510_myositis0.74112398
88MP0001943_abnormal_respiration0.73513579
89MP0001544_abnormal_cardiovascular_syste0.73349478
90MP0005385_cardiovascular_system_phenoty0.73349478
91MP0005266_abnormal_metabolism0.73166149
92MP0002638_abnormal_pupillary_reflex0.72270141
93MP0002210_abnormal_sex_determination0.72040682
94MP0002972_abnormal_cardiac_muscle0.71661485
95MP0003937_abnormal_limbs/digits/tail_de0.71108024
96MP0005508_abnormal_skeleton_morphology0.70738670
97MP0002734_abnormal_mechanical_nocicepti0.70720045
98MP0002114_abnormal_axial_skeleton0.69580929
99MP0003136_yellow_coat_color0.68649755
100MP0002161_abnormal_fertility/fecundity0.68586317
101MP0003942_abnormal_urinary_system0.67665819
102MP0001881_abnormal_mammary_gland0.67162224
103MP0001145_abnormal_male_reproductive0.66541521
104MP0005369_muscle_phenotype0.66159007
105MP0000749_muscle_degeneration0.65810980
106MP0000639_abnormal_adrenal_gland0.63509542
107MP0001501_abnormal_sleep_pattern0.63374131
108MP0003191_abnormal_cellular_cholesterol0.62821924
109MP0002822_catalepsy0.62722969
110MP0000631_abnormal_neuroendocrine_gland0.62543076
111MP0000372_irregular_coat_pigmentation0.62491434
112MP0003693_abnormal_embryo_hatching0.61664798
113MP0004270_analgesia0.60942639
114MP0003385_abnormal_body_wall0.60701254
115MP0003279_aneurysm0.59944915
116MP0000343_altered_response_to0.59701896
117MP0001851_eye_inflammation0.59597280
118MP0009250_abnormal_appendicular_skeleto0.59174096
119MP0001849_ear_inflammation0.59009027
120MP0004085_abnormal_heartbeat0.58818576
121MP0002233_abnormal_nose_morphology0.58359182
122MP0005410_abnormal_fertilization0.58033962
123MP0003787_abnormal_imprinting0.57441698
124MP0000266_abnormal_heart_morphology0.55476527
125MP0010630_abnormal_cardiac_muscle0.55433347
126MP0003091_abnormal_cell_migration0.53654535
127MP0000759_abnormal_skeletal_muscle0.53599413
128MP0001661_extended_life_span0.53479095
129MP0003137_abnormal_impulse_conducting0.52425636
130MP0002896_abnormal_bone_mineralization0.51212945
131MP0004233_abnormal_muscle_weight0.50875464
132MP0003948_abnormal_gas_homeostasis0.50830059
133MP0001984_abnormal_olfaction0.50464847
134MP0001299_abnormal_eye_distance/0.50442123
135MP0000762_abnormal_tongue_morphology0.50275853
136MP0002106_abnormal_muscle_physiology0.50270789
137MP0000609_abnormal_liver_physiology0.50013061
138MP0000427_abnormal_hair_cycle0.49699741
139MP0002127_abnormal_cardiovascular_syste0.49262895
140MP0008789_abnormal_olfactory_epithelium0.47334492
141MP0002234_abnormal_pharynx_morphology0.46808470
142MP0000049_abnormal_middle_ear0.42818879
143MP0002109_abnormal_limb_morphology0.42139296
144MP0000462_abnormal_digestive_system0.41943645
145MP0002116_abnormal_craniofacial_bone0.40923234
146MP0002115_abnormal_skeleton_extremities0.37564446
147MP0002113_abnormal_skeleton_development0.36575274
148MP0003935_abnormal_craniofacial_develop0.34533847
149MP0005165_increased_susceptibility_to0.33147857
150MP0002128_abnormal_blood_circulation0.33116197
151MP0000230_abnormal_systemic_arterial0.31479926
152MP0000163_abnormal_cartilage_morphology0.31025193
153MP0008770_decreased_survivor_rate0.29916744
154MP0000432_abnormal_head_morphology0.29880179
155MP0003755_abnormal_palate_morphology0.29351848
156MP0005220_abnormal_exocrine_pancreas0.29262063
157MP0001614_abnormal_blood_vessel0.28121027

Predicted human phenotypes

RankGene SetZ-score
1Ulnar deviation of the wrist (HP:0003049)9.83121787
2Male infertility (HP:0003251)7.17857414
3Absent phalangeal crease (HP:0006109)6.79761734
4Trismus (HP:0000211)6.57315979
5Breech presentation (HP:0001623)6.39745523
6Malignant hyperthermia (HP:0002047)5.96103168
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.95325446
8Abnormal finger flexion creases (HP:0006143)5.72047237
9Popliteal pterygium (HP:0009756)5.68710645
10Abnormality of the calcaneus (HP:0008364)5.52728038
11Insulin-resistant diabetes mellitus (HP:0000831)5.43796580
12Hypoalphalipoproteinemia (HP:0003233)5.13898122
13Acanthosis nigricans (HP:0000956)4.63555737
14Distal arthrogryposis (HP:0005684)4.45419331
15Chin dimple (HP:0010751)4.42123272
16Aplasia of the musculature (HP:0100854)4.40997431
17Neoplasm of the heart (HP:0100544)4.36079639
18Vascular tortuosity (HP:0004948)4.12976623
19Amniotic constriction ring (HP:0009775)4.04278738
20Abnormality of placental membranes (HP:0011409)4.04278738
21Subcapsular cataract (HP:0000523)3.99808701
22Hyperphosphatemia (HP:0002905)3.97426568
23Oligomenorrhea (HP:0000876)3.91871618
24Tubulointerstitial nephritis (HP:0001970)3.75921600
25Vascular calcification (HP:0004934)3.73907630
26Abnormal auditory evoked potentials (HP:0006958)3.71185810
27Cardiovascular calcification (HP:0011915)3.68959620
28Chronic bronchitis (HP:0004469)3.66621775
29Symphalangism affecting the phalanges of the hand (HP:0009773)3.61723039
30Arterial tortuosity (HP:0005116)3.60181116
31Hypertriglyceridemia (HP:0002155)3.54108152
32Ankle contracture (HP:0006466)3.51424186
33Exercise-induced myalgia (HP:0003738)3.50773126
34Abnormal respiratory motile cilium physiology (HP:0012261)3.50757971
35Akinesia (HP:0002304)3.45869091
36Abnormality of renal resorption (HP:0011038)3.45854034
37Taurodontia (HP:0000679)3.44891901
38Abnormality of permanent molar morphology (HP:0011071)3.44891901
39Abnormality of the dental root (HP:0006486)3.44891901
40Abnormality of molar (HP:0011077)3.28501022
41Abnormality of molar morphology (HP:0011070)3.28501022
42Calf muscle hypertrophy (HP:0008981)3.26697494
43Adrenal hypoplasia (HP:0000835)3.24938290
44Papillary thyroid carcinoma (HP:0002895)3.10791445
45Myopathic facies (HP:0002058)3.02211427
46Menstrual irregularities (HP:0000858)3.00232539
47Abnormality of the dental pulp (HP:0006479)3.00198103
48Limited hip movement (HP:0008800)2.99149707
49Muscle hypertrophy of the lower extremities (HP:0008968)2.87953319
50Abnormality of the calf musculature (HP:0001430)2.86115464
51Ulnar deviation of finger (HP:0009465)2.81642811
52Type 1 muscle fiber predominance (HP:0003803)2.81298400
53Cone-rod dystrophy (HP:0000548)2.81061837
54Hyporeflexia of lower limbs (HP:0002600)2.79669527
55Infertility (HP:0000789)2.77191407
56Rhinitis (HP:0012384)2.75276540
57Chronic hepatic failure (HP:0100626)2.72834693
58Tarsal synostosis (HP:0008368)2.71537293
59Aortic aneurysm (HP:0004942)2.70157956
60Insulin resistance (HP:0000855)2.69423365
61Type 2 muscle fiber atrophy (HP:0003554)2.69421588
62Gowers sign (HP:0003391)2.69106480
63Thin ribs (HP:0000883)2.61642164
64Increased purine levels (HP:0004368)2.60750801
65Hyperuricemia (HP:0002149)2.60750801
66Abnormality of the aortic arch (HP:0012303)2.58743149
67Increased connective tissue (HP:0009025)2.57776264
68Spondylolisthesis (HP:0003302)2.57464799
69Abnormal delivery (HP:0001787)2.54114095
70Adducted thumb (HP:0001181)2.53644216
71Renovascular hypertension (HP:0100817)2.53303562
72Synostosis involving bones of the lower limbs (HP:0009138)2.50874030
73Synostosis involving bones of the feet (HP:0009140)2.50874030
74EMG: myopathic abnormalities (HP:0003458)2.50131020
75Long clavicles (HP:0000890)2.49469355
76Webbed neck (HP:0000465)2.49314870
77Abnormality of the neuromuscular junction (HP:0003398)2.46894012
78Fatigable weakness (HP:0003473)2.46894012
79Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45479255
80Rocker bottom foot (HP:0001838)2.44321259
81Sudden death (HP:0001699)2.40651245
82Aortic dissection (HP:0002647)2.40071470
83Hyperglycinuria (HP:0003108)2.38655800
84Abnormal ciliary motility (HP:0012262)2.37162308
85Pterygium (HP:0001059)2.35936543
86Muscle fiber atrophy (HP:0100295)2.35333490
87Exercise-induced muscle cramps (HP:0003710)2.33479906
88Hypolipoproteinemia (HP:0010981)2.33357460
89Neck muscle weakness (HP:0000467)2.31785587
90Ulnar deviation of the hand or of fingers of the hand (HP:0001193)2.30917126
91Hypergonadotropic hypogonadism (HP:0000815)2.29212132
92Cortical dysplasia (HP:0002539)2.27984272
93Thyroid carcinoma (HP:0002890)2.26790006
94Pulmonary fibrosis (HP:0002206)2.26727578
95Absent/shortened dynein arms (HP:0200106)2.25108298
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.25108298
97Truncal obesity (HP:0001956)2.23599496
98Mask-like facies (HP:0000298)2.23340199
99Hypoplasia of the uterus (HP:0000013)2.22770159
100Capillary hemangiomas (HP:0005306)2.22137002
101Generalized aminoaciduria (HP:0002909)2.19237592
102Increased variability in muscle fiber diameter (HP:0003557)2.18931556
103Orthostatic hypotension (HP:0001278)2.18608324
104Calcaneovalgus deformity (HP:0001848)2.18001515
105Knee flexion contracture (HP:0006380)2.17461242
106Genu recurvatum (HP:0002816)2.15367266
107Abnormality of skeletal muscle fiber size (HP:0012084)2.14985860
108Aplasia involving bones of the extremities (HP:0009825)2.14777835
109Aplasia involving bones of the upper limbs (HP:0009823)2.14777835
110Aplasia of the phalanges of the hand (HP:0009802)2.14777835
111Shawl scrotum (HP:0000049)2.14761403
112Nasal speech (HP:0001611)2.14746703
113Fetal akinesia sequence (HP:0001989)2.14368372
114Asymmetric septal hypertrophy (HP:0001670)2.13697007
115Abnormality of fatty-acid metabolism (HP:0004359)2.13435895
116Nonprogressive disorder (HP:0003680)2.12244723
117Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09595894
118Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09028369
119Muscle fiber splitting (HP:0003555)2.08624931
120Cerebral aneurysm (HP:0004944)2.07957768
121Nemaline bodies (HP:0003798)2.04462688
122Flexion contracture of toe (HP:0005830)2.03729890
123Joint contractures involving the joints of the feet (HP:0100492)2.03729890
124Hypoplastic heart (HP:0001961)2.03195870
125Cystic hygroma (HP:0000476)1.98589147
126Deformed tarsal bones (HP:0008119)1.97940040
127Secondary amenorrhea (HP:0000869)1.97854271
128Shallow orbits (HP:0000586)1.97553210
129Myotonia (HP:0002486)1.96971825
130Abnormality of the fovea (HP:0000493)1.95388601
131Ventricular fibrillation (HP:0001663)1.95073637
132Weak cry (HP:0001612)1.93830160
133Neonatal respiratory distress (HP:0002643)1.93017528
134Difficulty running (HP:0009046)1.92436638
135Polar cataract (HP:0010696)1.91848992
136Camptodactyly of toe (HP:0001836)1.91806125
137Ketoacidosis (HP:0001993)1.87968058
138Enlarged penis (HP:0000040)1.86840683
139Fragile skin (HP:0001030)1.86056107
140Muscle fiber inclusion bodies (HP:0100299)1.85680807
141Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83071284
142Protrusio acetabuli (HP:0003179)1.82326742
143Hip contracture (HP:0003273)1.81901691
144Goiter (HP:0000853)1.81842420
145Hypoplasia of dental enamel (HP:0006297)1.81679652
146Tubulointerstitial abnormality (HP:0001969)1.81678159
147Round ear (HP:0100830)1.81662531
148Subaortic stenosis (HP:0001682)1.81136629
149Abnormality of the left ventricular outflow tract (HP:0011103)1.81136629
150Nephritis (HP:0000123)1.81025866
151Striae distensae (HP:0001065)1.78452499
152Peritonitis (HP:0002586)1.77810153
153Bulbar palsy (HP:0001283)1.77184608
154Accelerated skeletal maturation (HP:0005616)1.76894698
155Abnormality of the hepatic vasculature (HP:0006707)1.73763794
156Hemiparesis (HP:0001269)1.72277402
157Abnormality of dentin (HP:0010299)1.71516987
158Cutaneous syndactyly (HP:0012725)1.71504224
159Metatarsus adductus (HP:0001840)1.70915930
160Progressive sensorineural hearing impairment (HP:0000408)1.70007257
161Annular pancreas (HP:0001734)1.69634851
162Chorioretinal atrophy (HP:0000533)1.69293184
163Diminished movement (HP:0002374)1.65318103
164Centrally nucleated skeletal muscle fibers (HP:0003687)1.62259794
165Scapular winging (HP:0003691)1.60438891
166Vertebral clefting (HP:0008428)1.59227497
167Generalized muscle weakness (HP:0003324)1.57898165
168Soft skin (HP:0000977)1.54976349
169Limb-girdle muscle atrophy (HP:0003797)1.50750789
170Narrow mouth (HP:0000160)1.49603476
171Premature rupture of membranes (HP:0001788)1.49295586
172Hypoplastic ischia (HP:0003175)1.47353916
173Deep philtrum (HP:0002002)1.45930523
174Mildly elevated creatine phosphokinase (HP:0008180)1.44324344
175Easy fatigability (HP:0003388)1.44133103
176Abnormality of the ischium (HP:0003174)1.43227921
177Rib fusion (HP:0000902)1.40906414
178Flat face (HP:0012368)1.40082168
179Narrow face (HP:0000275)1.38680299
180EMG: neuropathic changes (HP:0003445)1.37792618
181Hypoplastic nipples (HP:0002557)1.35978240
182Thin bony cortex (HP:0002753)1.35583017
183Asymmetry of the thorax (HP:0001555)1.34765044
184Arthrogryposis multiplex congenita (HP:0002804)1.33590820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.17348617
2LATS14.13511245
3LATS24.03994472
4MAP3K63.30714964
5KSR23.13398834
6MAP3K103.12127512
7MUSK3.04703904
8MOS2.80042660
9MELK2.76537728
10EEF2K2.63715576
11TRIB32.63099301
12ERBB42.60410065
13PRKD32.59699165
14MAP3K92.40148160
15STK38L2.36388553
16TTK2.32151463
17NEK92.14139606
18PLK41.92952541
19TNIK1.89345079
20TAOK31.88586011
21RET1.81422617
22TTN1.80209741
23RAF11.79853228
24SCYL21.72170262
25MAPKAPK31.69132458
26PTK61.63479088
27TAOK11.62179600
28MAP3K131.58065093
29PAK61.55592222
30TIE11.50622904
31BRAF1.50298941
32MAP3K51.49737183
33MAP3K71.46730460
34STK31.46598154
35CAMK1D1.44988160
36FGFR41.43745115
37CDK91.42532819
38MAPK71.41802098
39ARAF1.37579470
40CHEK21.34713233
41CDK121.34383458
42CCNB11.29649079
43PRKAA21.29619443
44KSR11.24609543
45BMPR21.21326154
46ABL21.19790398
47MAPK151.14602240
48CDK191.12475403
49MARK11.06333463
50TESK11.04621218
51CDC71.03655265
52MAPK131.02960416
53NME10.99423960
54STK100.99241211
55DYRK20.97763575
56STK390.96389594
57STK380.94849938
58MAPK110.91660576
59PRKAA10.90496898
60MAPKAPK50.89378995
61EPHB10.89055638
62PDPK10.83034013
63CAMK1G0.82408599
64TRPM70.82205401
65DMPK0.81073460
66ILK0.80899157
67PRKD20.80839354
68NUAK10.80760820
69TYRO30.79680064
70PDK30.78408876
71PDK40.78408876
72MYLK0.77100269
73PDK10.76469374
74CASK0.72901056
75MAP3K40.72162175
76BCKDK0.71230214
77PHKG10.67632696
78PHKG20.67632696
79MAP2K10.67207006
80CAMK2G0.67004092
81AKT20.64140152
82CDK80.62969469
83FRK0.62002285
84MAP2K70.59451420
85JAK20.56723606
86MAP3K80.54281758
87KDR0.52869399
88PLK10.52553066
89WNK40.50668680
90MARK20.48899750
91PRKCH0.48493648
92SIK10.47882693
93NEK20.47335338
94LIMK10.45738059
95PIK3CA0.45524691
96RIPK10.44988552
97LMTK20.43809742
98ABL10.43015150
99PTK20.42580404
100NTRK20.41957882
101MAPK40.41560033
102CSK0.41411272
103PDK20.40307416
104NTRK30.39879392
105OBSCN0.39695767
106PRPF4B0.39501897
107PLK30.39333870
108CDK60.38038470
109PKN20.37289954
110RPS6KA30.36447527
111PRKACA0.36189939
112MAP2K40.35694974
113IGF1R0.34487191
114RPS6KB10.34167979
115STK240.33947159
116PASK0.33487868
117VRK10.33303896
118PIK3CG0.32645409
119WNK10.32587001
120ICK0.32028461
121PTK2B0.30320619
122CDC42BPA0.30043393
123CSNK1G10.29961792
124RPS6KB20.29741690
125PRKCQ0.28623071
126TGFBR20.28013506
127CAMK2A0.27959045
128CDK11A0.27680949
129PDGFRA0.26736488
130TESK20.26561177
131CDK150.26478110
132RPS6KA20.26159526
133FGFR20.25073294
134MAPK120.25062420
135EPHB20.24823247
136CSNK1D0.23916171
137KIT0.23536920
138ROCK20.22464742
139PRKACB0.22351370
140ERN10.22215525
141LRRK20.21935271
142PRKG10.21923192
143ROCK10.21161179
144MTOR0.21139405
145CDK180.20114089
146ERBB30.19878920
147SGK20.19851451
148MAPKAPK20.19256357
149CSNK1G20.16444689
150CSNK1A1L0.15807670
151TNK20.15795265
152PAK20.14739869

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.74254564
2PPAR signaling pathway_Homo sapiens_hsa033203.06557263
3Cardiac muscle contraction_Homo sapiens_hsa042602.80045193
4Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.68912205
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.68803166
6Fatty acid biosynthesis_Homo sapiens_hsa000612.54458637
7Ovarian steroidogenesis_Homo sapiens_hsa049132.39135087
8Phototransduction_Homo sapiens_hsa047442.24946621
9Vitamin B6 metabolism_Homo sapiens_hsa007502.23260085
10Fatty acid metabolism_Homo sapiens_hsa012122.13018732
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.11790523
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02572021
13Renin secretion_Homo sapiens_hsa049242.00190264
14Glycerolipid metabolism_Homo sapiens_hsa005611.97735875
15Oxytocin signaling pathway_Homo sapiens_hsa049211.94246774
16AMPK signaling pathway_Homo sapiens_hsa041521.92814714
17Renin-angiotensin system_Homo sapiens_hsa046141.84323930
18Longevity regulating pathway - mammal_Homo sapiens_hsa042111.77704414
19Cell cycle_Homo sapiens_hsa041101.77300504
20Calcium signaling pathway_Homo sapiens_hsa040201.74516572
21Ether lipid metabolism_Homo sapiens_hsa005651.72768680
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69859072
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63342484
24Circadian entrainment_Homo sapiens_hsa047131.62652312
25Fatty acid degradation_Homo sapiens_hsa000711.55335953
26mTOR signaling pathway_Homo sapiens_hsa041501.53374145
27Circadian rhythm_Homo sapiens_hsa047101.50106220
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46642609
29Pancreatic cancer_Homo sapiens_hsa052121.46422509
30TGF-beta signaling pathway_Homo sapiens_hsa043501.43308825
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36342591
32Glioma_Homo sapiens_hsa052141.34665995
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31215798
34Long-term potentiation_Homo sapiens_hsa047201.30961854
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.29968586
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29164018
37Oocyte meiosis_Homo sapiens_hsa041141.26024902
38Amphetamine addiction_Homo sapiens_hsa050311.24610307
39Starch and sucrose metabolism_Homo sapiens_hsa005001.24361346
40Olfactory transduction_Homo sapiens_hsa047401.21287138
41Viral myocarditis_Homo sapiens_hsa054161.20931408
42Melanogenesis_Homo sapiens_hsa049161.20701754
43Linoleic acid metabolism_Homo sapiens_hsa005911.20164918
44Insulin secretion_Homo sapiens_hsa049111.17868117
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17451139
46Fatty acid elongation_Homo sapiens_hsa000621.16940248
47RNA degradation_Homo sapiens_hsa030181.14415038
48Choline metabolism in cancer_Homo sapiens_hsa052311.13632646
49Retinol metabolism_Homo sapiens_hsa008301.13124879
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06015902
51Pyruvate metabolism_Homo sapiens_hsa006201.04122802
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.02257461
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.01710524
54Renal cell carcinoma_Homo sapiens_hsa052111.01097430
55Endometrial cancer_Homo sapiens_hsa052131.01023107
56Glucagon signaling pathway_Homo sapiens_hsa049221.01017172
57Dorso-ventral axis formation_Homo sapiens_hsa043200.99515094
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99308993
59Adherens junction_Homo sapiens_hsa045200.98805357
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98068943
61Insulin resistance_Homo sapiens_hsa049310.96709032
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95942878
63Nitrogen metabolism_Homo sapiens_hsa009100.94536549
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92904974
65GnRH signaling pathway_Homo sapiens_hsa049120.92431211
66Hedgehog signaling pathway_Homo sapiens_hsa043400.91708420
67Focal adhesion_Homo sapiens_hsa045100.91443090
68beta-Alanine metabolism_Homo sapiens_hsa004100.90647719
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.89764705
70FoxO signaling pathway_Homo sapiens_hsa040680.89449947
71ECM-receptor interaction_Homo sapiens_hsa045120.87190628
72Prion diseases_Homo sapiens_hsa050200.86572550
73Hippo signaling pathway_Homo sapiens_hsa043900.85543709
74Butanoate metabolism_Homo sapiens_hsa006500.85372077
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84382532
76Colorectal cancer_Homo sapiens_hsa052100.83373447
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82899204
78Insulin signaling pathway_Homo sapiens_hsa049100.81461142
79Small cell lung cancer_Homo sapiens_hsa052220.79124623
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78299836
81Carbon metabolism_Homo sapiens_hsa012000.77836050
82p53 signaling pathway_Homo sapiens_hsa041150.77224151
83Prolactin signaling pathway_Homo sapiens_hsa049170.76563814
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71659432
85Non-small cell lung cancer_Homo sapiens_hsa052230.68516978
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68382262
87Peroxisome_Homo sapiens_hsa041460.67892236
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67557751
89Estrogen signaling pathway_Homo sapiens_hsa049150.67402466
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66758878
91MicroRNAs in cancer_Homo sapiens_hsa052060.66308299
92Gap junction_Homo sapiens_hsa045400.65629350
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65505213
94Prostate cancer_Homo sapiens_hsa052150.65462486
95MAPK signaling pathway_Homo sapiens_hsa040100.64889290
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.64315499
97Dilated cardiomyopathy_Homo sapiens_hsa054140.63942801
98Platelet activation_Homo sapiens_hsa046110.63039607
99VEGF signaling pathway_Homo sapiens_hsa043700.62559293
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.61818462
101Malaria_Homo sapiens_hsa051440.61396977
102Long-term depression_Homo sapiens_hsa047300.61381753
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.61112436
104Basal cell carcinoma_Homo sapiens_hsa052170.60954459
105Pertussis_Homo sapiens_hsa051330.59614313
106Pancreatic secretion_Homo sapiens_hsa049720.58814093
107Cholinergic synapse_Homo sapiens_hsa047250.58212381
108Basal transcription factors_Homo sapiens_hsa030220.57256032
109Dopaminergic synapse_Homo sapiens_hsa047280.57032888
110Bile secretion_Homo sapiens_hsa049760.56383510
111cAMP signaling pathway_Homo sapiens_hsa040240.56367312
112Arachidonic acid metabolism_Homo sapiens_hsa005900.56210088
113Toxoplasmosis_Homo sapiens_hsa051450.56202292
114Notch signaling pathway_Homo sapiens_hsa043300.56092600
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54953513
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.53238912
117Axon guidance_Homo sapiens_hsa043600.53077997
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51719788
119Caffeine metabolism_Homo sapiens_hsa002320.50464050
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50220158
121Rap1 signaling pathway_Homo sapiens_hsa040150.48947126
122Tight junction_Homo sapiens_hsa045300.47406243
123Thyroid cancer_Homo sapiens_hsa052160.44667571
124Tyrosine metabolism_Homo sapiens_hsa003500.42888016
125Wnt signaling pathway_Homo sapiens_hsa043100.42346738
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41895527
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41557410
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.40535431
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40043572
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39544528
131Inositol phosphate metabolism_Homo sapiens_hsa005620.39135021
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37227449
133Proteoglycans in cancer_Homo sapiens_hsa052050.36498449
134Ras signaling pathway_Homo sapiens_hsa040140.36430002
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36045248
136Protein digestion and absorption_Homo sapiens_hsa049740.35498853
137Salivary secretion_Homo sapiens_hsa049700.35403096
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33618534
139Mineral absorption_Homo sapiens_hsa049780.33545095
140Melanoma_Homo sapiens_hsa052180.32047863
141Thyroid hormone synthesis_Homo sapiens_hsa049180.31880070
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31827112
143Cocaine addiction_Homo sapiens_hsa050300.31155669
144Amoebiasis_Homo sapiens_hsa051460.29764341
145Gastric acid secretion_Homo sapiens_hsa049710.29549309
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28571362
147Pathways in cancer_Homo sapiens_hsa052000.27168326
148Lysine degradation_Homo sapiens_hsa003100.25031768
149Histidine metabolism_Homo sapiens_hsa003400.24884015
150Arginine and proline metabolism_Homo sapiens_hsa003300.22155893
151Alcoholism_Homo sapiens_hsa050340.21037253
152ErbB signaling pathway_Homo sapiens_hsa040120.18942816

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