PRR36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein of unknown function that contains internal regions of low complexity sequence. Alternative splicing results in multiple transcript variants. The transcript structure of the protein-coding variant at this locus is conserved between human and mouse. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.46605563
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56141063
3neuron cell-cell adhesion (GO:0007158)5.53720561
4response to pheromone (GO:0019236)5.48662567
5neuron recognition (GO:0008038)5.36938954
6axonal fasciculation (GO:0007413)5.25543283
7vocalization behavior (GO:0071625)5.21220401
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.18504491
9nucleobase catabolic process (GO:0046113)5.15664917
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10683581
11layer formation in cerebral cortex (GO:0021819)5.09290940
12dendritic spine morphogenesis (GO:0060997)5.07864907
13cell migration in hindbrain (GO:0021535)4.86393345
14protein localization to synapse (GO:0035418)4.85634842
15synaptic vesicle exocytosis (GO:0016079)4.65573685
16synaptic vesicle maturation (GO:0016188)4.63099253
17regulation of glutamate receptor signaling pathway (GO:1900449)4.54648950
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.51407111
19central nervous system projection neuron axonogenesis (GO:0021952)4.49561377
20locomotory exploration behavior (GO:0035641)4.38605054
21glutamate secretion (GO:0014047)4.28241190
22exploration behavior (GO:0035640)4.22709385
23negative regulation of microtubule polymerization (GO:0031115)4.16303360
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.14595995
25regulation of synaptic vesicle exocytosis (GO:2000300)4.13766814
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.09610422
27neuronal ion channel clustering (GO:0045161)3.98995538
28regulation of synapse structural plasticity (GO:0051823)3.97471503
29positive regulation of synapse maturation (GO:0090129)3.97204629
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95002923
31postsynaptic membrane organization (GO:0001941)3.92601136
32dendrite morphogenesis (GO:0048813)3.92077137
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.83491527
34regulation of neuronal synaptic plasticity (GO:0048168)3.81870035
35regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.77462376
36positive regulation of synapse assembly (GO:0051965)3.77196248
37establishment of mitochondrion localization (GO:0051654)3.75805721
38presynaptic membrane organization (GO:0097090)3.75588891
39innervation (GO:0060384)3.69439642
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69072175
41regulation of synaptic vesicle transport (GO:1902803)3.67540864
42synaptic transmission, glutamatergic (GO:0035249)3.67392174
43transmission of nerve impulse (GO:0019226)3.66630138
44presynaptic membrane assembly (GO:0097105)3.63033253
45glutamate receptor signaling pathway (GO:0007215)3.58265301
46hippocampus development (GO:0021766)3.57708128
47neurotransmitter secretion (GO:0007269)3.54412337
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50657771
49cellular potassium ion homeostasis (GO:0030007)3.50232311
50cerebellum development (GO:0021549)3.47050950
51cerebellar Purkinje cell differentiation (GO:0021702)3.45812136
52regulation of respiratory system process (GO:0044065)3.43284695
53central nervous system neuron axonogenesis (GO:0021955)3.43198464
54auditory behavior (GO:0031223)3.43059541
55sodium ion export (GO:0071436)3.34036708
56neurotransmitter-gated ion channel clustering (GO:0072578)3.33127582
57neuron-neuron synaptic transmission (GO:0007270)3.30214445
58dendritic spine organization (GO:0097061)3.29057708
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28009885
60neuromuscular synaptic transmission (GO:0007274)3.27693058
61cerebral cortex radially oriented cell migration (GO:0021799)3.26689025
62axon extension (GO:0048675)3.26476408
63regulation of synapse assembly (GO:0051963)3.24450921
64synaptic vesicle endocytosis (GO:0048488)3.22468729
65synapse assembly (GO:0007416)3.21801819
66neuromuscular process controlling balance (GO:0050885)3.21103097
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.20378969
68regulation of neurotransmitter levels (GO:0001505)3.19886497
69spinal cord development (GO:0021510)3.19479523
70regulation of synapse maturation (GO:0090128)3.18300418
71regulation of postsynaptic membrane potential (GO:0060078)3.18189439
72regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17040430
73regulation of dendritic spine morphogenesis (GO:0061001)3.15173536
74positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14350833
75response to auditory stimulus (GO:0010996)3.14215008
76neuronal action potential propagation (GO:0019227)3.14148517
77regulation of synapse organization (GO:0050807)3.13946921
78establishment of nucleus localization (GO:0040023)3.10318859
79regulation of respiratory gaseous exchange (GO:0043576)3.09430044
80positive regulation of dendritic spine development (GO:0060999)3.09098705
81forebrain neuron differentiation (GO:0021879)3.05849799
82membrane hyperpolarization (GO:0060081)3.05593743
83neuron migration (GO:0001764)3.02786085
84positive regulation of membrane potential (GO:0045838)3.02481967
85proline transport (GO:0015824)3.02246353
86chemosensory behavior (GO:0007635)3.01370605
87negative regulation of oligodendrocyte differentiation (GO:0048715)2.99982431
88gamma-aminobutyric acid signaling pathway (GO:0007214)2.98502120
89membrane depolarization during action potential (GO:0086010)2.96447856
90dendrite development (GO:0016358)2.96330155
91long-term memory (GO:0007616)2.94136689
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93211369
93synapse organization (GO:0050808)2.91818563
94behavioral defense response (GO:0002209)2.91574587
95behavioral fear response (GO:0001662)2.91574587
96axon ensheathment in central nervous system (GO:0032291)2.90908372
97central nervous system myelination (GO:0022010)2.90908372
98mechanosensory behavior (GO:0007638)2.89977387
99regulation of neurotransmitter transport (GO:0051588)2.88198864
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86549760
101neuron projection extension (GO:1990138)2.85881968
102membrane depolarization (GO:0051899)2.82899611
103adult walking behavior (GO:0007628)2.82844595
104regulation of synaptic plasticity (GO:0048167)2.82628010
105cerebellar Purkinje cell layer development (GO:0021680)2.81906794
106cell-cell junction maintenance (GO:0045217)2.81891132
107regulation of vesicle fusion (GO:0031338)2.81206672
108cerebral cortex neuron differentiation (GO:0021895)2.81134724
109negative regulation of axon extension (GO:0030517)2.80636156
110neurotransmitter transport (GO:0006836)2.78483781
111adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78428902
112cerebellar granule cell differentiation (GO:0021707)2.78193869
113gamma-aminobutyric acid transport (GO:0015812)2.77749604
114cell differentiation in hindbrain (GO:0021533)2.77439118
115negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76663197
116negative regulation of axonogenesis (GO:0050771)2.75835067
117social behavior (GO:0035176)2.75761092
118intraspecies interaction between organisms (GO:0051703)2.75761092
119cochlea development (GO:0090102)2.75717883
120cell communication by electrical coupling (GO:0010644)2.75055737
121learning (GO:0007612)2.74856582
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73938738
123mitochondrion transport along microtubule (GO:0047497)2.73493337
124establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.73493337
125regulation of neurotransmitter secretion (GO:0046928)2.73339048
126retinal ganglion cell axon guidance (GO:0031290)2.73029663
127neuromuscular process controlling posture (GO:0050884)2.68626295
128neuromuscular process (GO:0050905)2.67847047
129L-amino acid import (GO:0043092)2.67160869
130regulation of dendrite morphogenesis (GO:0048814)2.66479585
131positive regulation of dendrite development (GO:1900006)2.65952585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.72720589
2GBX2_23144817_ChIP-Seq_PC3_Human3.41899183
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07110111
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.05910516
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.05260318
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.99933875
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90772719
8REST_21632747_ChIP-Seq_MESCs_Mouse2.78224524
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72884067
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72884067
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72604302
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66471261
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61656611
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57398815
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.51236196
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41032223
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.40703172
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.38395594
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37545518
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36523609
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30688575
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.29898268
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27902283
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20831027
25DROSHA_22980978_ChIP-Seq_HELA_Human2.18077184
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11698072
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.09812824
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04197683
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.00036572
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96671662
31IGF1R_20145208_ChIP-Seq_DFB_Human1.86403404
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86292795
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85218055
34ZNF274_21170338_ChIP-Seq_K562_Hela1.83083726
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73732566
36CTCF_27219007_Chip-Seq_Bcells_Human1.70723953
37RNF2_27304074_Chip-Seq_NSC_Mouse1.70367773
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64986965
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.64958132
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64877490
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64665840
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61190975
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58153333
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.55518796
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53132756
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48258114
47TAF15_26573619_Chip-Seq_HEK293_Human1.45245663
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.45068342
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.44439840
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41763312
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41291619
52AR_21572438_ChIP-Seq_LNCaP_Human1.34918900
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33447389
54SMAD4_21799915_ChIP-Seq_A2780_Human1.30466760
55LXR_22292898_ChIP-Seq_THP-1_Human1.29913671
56P300_19829295_ChIP-Seq_ESCs_Human1.28575295
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28379384
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26899610
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26044760
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.19699932
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17669789
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17669789
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17312223
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.15734762
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15183428
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14917912
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14847586
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.13801728
69SMC4_20622854_ChIP-Seq_HELA_Human1.13088993
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12419072
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12048334
72AR_19668381_ChIP-Seq_PC3_Human1.11977916
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11279553
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10801767
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10739019
76CREB1_26743006_Chip-Seq_LNCaP_Human1.10118123
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10001741
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.09596383
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09413307
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09311521
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08102086
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07488898
83P68_20966046_ChIP-Seq_HELA_Human1.06754770
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06435687
85OCT4_19829295_ChIP-Seq_ESCs_Human1.05731049
86KDM2B_26808549_Chip-Seq_K562_Human1.04962579
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04624862
88AR_25329375_ChIP-Seq_VCAP_Human1.04591769
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02994206
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02492311
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02097981
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02063250
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00692756
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00355346
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99908963
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97148572
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.96865594
98ARNT_22903824_ChIP-Seq_MCF-7_Human0.96116482
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95881399
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95493527
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94922786
102MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94647830
103FUS_26573619_Chip-Seq_HEK293_Human0.94118194
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93971513
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.93605423
106KDM2B_26808549_Chip-Seq_DND41_Human0.92572674
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90550329
108STAT3_23295773_ChIP-Seq_U87_Human0.90465302
109AHR_22903824_ChIP-Seq_MCF-7_Human0.89558402
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88676038
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.88392835
112SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88232660
113RUNX2_22187159_ChIP-Seq_PCA_Human0.87344586
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.87341285
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87173940
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87128049
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86845777
118ELK4_26923725_Chip-Seq_MESODERM_Mouse0.86471858
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86087485
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86072526
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85963349
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.85620932
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85559738
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.84208329
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83921323
126POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83240755
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82928699
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82562122
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80035222
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77247471
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.76012258
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74851091
133KLF4_19829295_ChIP-Seq_ESCs_Human0.72358904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.19020872
2MP0003880_abnormal_central_pattern4.68279195
3MP0005423_abnormal_somatic_nervous3.65773513
4MP0003635_abnormal_synaptic_transmissio3.37533178
5MP0000778_abnormal_nervous_system3.26217577
6MP0004270_analgesia3.18178683
7MP0002063_abnormal_learning/memory/cond2.93628945
8MP0006276_abnormal_autonomic_nervous2.69335523
9MP0009745_abnormal_behavioral_response2.53162791
10MP0001968_abnormal_touch/_nociception2.39231192
11MP0002572_abnormal_emotion/affect_behav2.35927336
12MP0002184_abnormal_innervation2.34593236
13MP0002064_seizures2.32703824
14MP0002734_abnormal_mechanical_nocicepti2.19883459
15MP0001529_abnormal_vocalization2.17996992
16MP0003122_maternal_imprinting2.15672025
17MP0001486_abnormal_startle_reflex2.09318845
18MP0005645_abnormal_hypothalamus_physiol1.98569400
19MP0002557_abnormal_social/conspecific_i1.96463271
20MP0004811_abnormal_neuron_physiology1.93368110
21MP0001984_abnormal_olfaction1.91747135
22MP0002733_abnormal_thermal_nociception1.87255322
23MP0009046_muscle_twitch1.86872254
24MP0001440_abnormal_grooming_behavior1.84961620
25MP0006292_abnormal_olfactory_placode1.84220616
26MP0005499_abnormal_olfactory_system1.83675537
27MP0005394_taste/olfaction_phenotype1.83675537
28MP0002272_abnormal_nervous_system1.83038463
29MP0000955_abnormal_spinal_cord1.82151763
30MP0002735_abnormal_chemical_nociception1.79206190
31MP0002736_abnormal_nociception_after1.79027986
32MP0003123_paternal_imprinting1.75775552
33MP0002249_abnormal_larynx_morphology1.72724405
34MP0008789_abnormal_olfactory_epithelium1.68008618
35MP0002067_abnormal_sensory_capabilities1.66680971
36MP0000569_abnormal_digit_pigmentation1.65381843
37MP0003878_abnormal_ear_physiology1.64706903
38MP0005377_hearing/vestibular/ear_phenot1.64706903
39MP0002882_abnormal_neuron_morphology1.63385986
40MP0001970_abnormal_pain_threshold1.58303288
41MP0004858_abnormal_nervous_system1.57516982
42MP0004924_abnormal_behavior1.54877684
43MP0005386_behavior/neurological_phenoty1.54877684
44MP0002152_abnormal_brain_morphology1.53537719
45MP0002653_abnormal_ependyma_morphology1.52429134
46MP0003787_abnormal_imprinting1.52107846
47MP0000631_abnormal_neuroendocrine_gland1.45958943
48MP0004885_abnormal_endolymph1.44969396
49MP0003861_abnormal_nervous_system1.44029695
50MP0000537_abnormal_urethra_morphology1.36784049
51MP0002234_abnormal_pharynx_morphology1.35868825
52MP0002751_abnormal_autonomic_nervous1.34748468
53MP0002102_abnormal_ear_morphology1.33396002
54MP0005187_abnormal_penis_morphology1.31342723
55MP0001501_abnormal_sleep_pattern1.29658790
56MP0003890_abnormal_embryonic-extraembry1.29340495
57MP0001502_abnormal_circadian_rhythm1.27613172
58MP0003121_genomic_imprinting1.27246868
59MP0002066_abnormal_motor_capabilities/c1.26123460
60MP0003283_abnormal_digestive_organ1.25941108
61MP0002909_abnormal_adrenal_gland1.24507869
62MP0005646_abnormal_pituitary_gland1.21681094
63MP0001485_abnormal_pinna_reflex1.21175338
64MP0003119_abnormal_digestive_system1.20846161
65MP0008569_lethality_at_weaning1.20218572
66MP0009780_abnormal_chondrocyte_physiolo1.15989249
67MP0004742_abnormal_vestibular_system1.14300369
68MP0010030_abnormal_orbit_morphology1.13293691
69MP0003879_abnormal_hair_cell1.12215425
70MP0002752_abnormal_somatic_nervous1.11869236
71MP0003329_amyloid_beta_deposits1.09653718
72MP0003938_abnormal_ear_development1.06660218
73MP0004133_heterotaxia1.04138230
74MP0002638_abnormal_pupillary_reflex1.03053042
75MP0002069_abnormal_eating/drinking_beha1.00462335
76MP0000049_abnormal_middle_ear0.99215505
77MP0001905_abnormal_dopamine_level0.98169158
78MP0008961_abnormal_basal_metabolism0.97749302
79MP0000026_abnormal_inner_ear0.97541735
80MP0001348_abnormal_lacrimal_gland0.96747368
81MP0001188_hyperpigmentation0.95601214
82MP0003136_yellow_coat_color0.95480459
83MP0004142_abnormal_muscle_tone0.90660078
84MP0003942_abnormal_urinary_system0.90469631
85MP0003137_abnormal_impulse_conducting0.87508873
86MP0005248_abnormal_Harderian_gland0.87036244
87MP0006072_abnormal_retinal_apoptosis0.85456419
88MP0001299_abnormal_eye_distance/0.85412020
89MP0001177_atelectasis0.84792587
90MP0001963_abnormal_hearing_physiology0.84734850
91MP0002089_abnormal_postnatal_growth/wei0.83788870
92MP0002822_catalepsy0.81767198
93MP0002081_perinatal_lethality0.80606490
94MP0000579_abnormal_nail_morphology0.80312140
95MP0004145_abnormal_muscle_electrophysio0.78851795
96MP0005551_abnormal_eye_electrophysiolog0.78608636
97MP0005409_darkened_coat_color0.76582902
98MP0010386_abnormal_urinary_bladder0.76128553
99MP0003315_abnormal_perineum_morphology0.75704260
100MP0008877_abnormal_DNA_methylation0.75494115
101MP0000751_myopathy0.75233401
102MP0003633_abnormal_nervous_system0.69930577
103MP0001943_abnormal_respiration0.69859748
104MP0003632_abnormal_nervous_system0.68737086
105MP0002082_postnatal_lethality0.68696107
106MP0010770_preweaning_lethality0.68696107
107MP0000534_abnormal_ureter_morphology0.68633363
108MP0002116_abnormal_craniofacial_bone0.68136949
109MP0003634_abnormal_glial_cell0.68118713
110MP0003631_nervous_system_phenotype0.68060508
111MP0003385_abnormal_body_wall0.66571690
112MP0004085_abnormal_heartbeat0.66436733
113MP0010769_abnormal_survival0.66308543
114MP0002229_neurodegeneration0.65067545
115MP0002938_white_spotting0.64384713
116MP0000566_synostosis0.64104400

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.69153292
2Myokymia (HP:0002411)4.45849124
3Focal seizures (HP:0007359)4.04566699
4Epileptic encephalopathy (HP:0200134)3.93618586
5Visual hallucinations (HP:0002367)3.70344308
6Abnormality of binocular vision (HP:0011514)3.59351807
7Diplopia (HP:0000651)3.59351807
8Limb dystonia (HP:0002451)3.37911415
9Progressive cerebellar ataxia (HP:0002073)3.30295576
10Supranuclear gaze palsy (HP:0000605)3.21679956
11Broad-based gait (HP:0002136)3.15703345
12Febrile seizures (HP:0002373)3.15203290
13Drooling (HP:0002307)3.14554890
14Excessive salivation (HP:0003781)3.14554890
15Amblyopia (HP:0000646)3.13875989
16Polyphagia (HP:0002591)3.06250958
17Ankle clonus (HP:0011448)3.00350194
18Amyotrophic lateral sclerosis (HP:0007354)2.99025492
19Lissencephaly (HP:0001339)2.82760239
20Mutism (HP:0002300)2.81057659
21Hyperventilation (HP:0002883)2.77570815
22Shoulder girdle muscle weakness (HP:0003547)2.72681201
23Atonic seizures (HP:0010819)2.68361175
24Failure to thrive in infancy (HP:0001531)2.66773045
25Hypoplasia of the brainstem (HP:0002365)2.65655229
26Aplasia/Hypoplasia of the brainstem (HP:0007362)2.65655229
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.65205805
28Abnormal eating behavior (HP:0100738)2.64039133
29Absence seizures (HP:0002121)2.62520940
30Poor eye contact (HP:0000817)2.57178632
31Retinal dysplasia (HP:0007973)2.56338902
32Genetic anticipation (HP:0003743)2.56269032
33Insomnia (HP:0100785)2.54928318
34Hemiparesis (HP:0001269)2.53883153
35Truncal ataxia (HP:0002078)2.49428929
36Absent speech (HP:0001344)2.48292582
37Epileptiform EEG discharges (HP:0011182)2.47602370
38EEG with generalized epileptiform discharges (HP:0011198)2.45774923
39Agitation (HP:0000713)2.45655498
40Hypsarrhythmia (HP:0002521)2.39710046
41Exotropia (HP:0000577)2.38123135
42Dialeptic seizures (HP:0011146)2.36064187
43Sleep apnea (HP:0010535)2.35863384
44Specific learning disability (HP:0001328)2.35222583
45Impaired vibration sensation in the lower limbs (HP:0002166)2.33491083
46Bronchomalacia (HP:0002780)2.32980779
47Abnormality of the lower motor neuron (HP:0002366)2.32801027
48Pachygyria (HP:0001302)2.30307564
49Generalized tonic-clonic seizures (HP:0002069)2.29141352
50Depression (HP:0000716)2.28242108
51Abnormality of the aortic arch (HP:0012303)2.27938547
52Progressive inability to walk (HP:0002505)2.25806951
53Hypoventilation (HP:0002791)2.25195399
54Postural instability (HP:0002172)2.24741412
55Annular pancreas (HP:0001734)2.21145332
56Urinary bladder sphincter dysfunction (HP:0002839)2.20114769
57Abnormal social behavior (HP:0012433)2.20070498
58Impaired social interactions (HP:0000735)2.20070498
59Hepatoblastoma (HP:0002884)2.19926712
60Elfin facies (HP:0004428)2.19527790
61Abnormality of the diencephalon (HP:0010662)2.19355397
62Hyperacusis (HP:0010780)2.17315225
63Abnormality of the corticospinal tract (HP:0002492)2.15560370
64Papilledema (HP:0001085)2.13915087
65Urinary urgency (HP:0000012)2.13154411
66Trigonocephaly (HP:0000243)2.13099835
67Gait imbalance (HP:0002141)2.12037999
68Pointed chin (HP:0000307)2.11402081
69Abnormality of the labia minora (HP:0012880)2.10167501
70Megalencephaly (HP:0001355)2.09945161
71Hypoplastic ischia (HP:0003175)2.09741812
72Turricephaly (HP:0000262)2.08191975
73Sacral dimple (HP:0000960)2.08187448
74Action tremor (HP:0002345)2.07793747
75Neurofibrillary tangles (HP:0002185)2.07773963
76Protruding tongue (HP:0010808)2.05608275
77Autism (HP:0000717)2.05011085
78Tented upper lip vermilion (HP:0010804)2.03715936
79Spastic gait (HP:0002064)2.01928725
80Inability to walk (HP:0002540)1.99971626
81Neoplasm of the heart (HP:0100544)1.99281310
82Stereotypic behavior (HP:0000733)1.96825102
83Hyperthyroidism (HP:0000836)1.96565952
84Status epilepticus (HP:0002133)1.95015075
85Anxiety (HP:0000739)1.94779301
86Vitreoretinal degeneration (HP:0000655)1.94234736
87Renal duplication (HP:0000075)1.94225277
88Abnormality of salivation (HP:0100755)1.93584257
89Abnormality of the ischium (HP:0003174)1.93517485
90Sporadic (HP:0003745)1.92695640
91Esotropia (HP:0000565)1.92608739
92Impaired smooth pursuit (HP:0007772)1.91710737
93Torticollis (HP:0000473)1.91463226
94Hypoplasia of the corpus callosum (HP:0002079)1.91177864
95Obstructive sleep apnea (HP:0002870)1.90466671
96Pelvic girdle muscle weakness (HP:0003749)1.89518217
97Anosmia (HP:0000458)1.89402829
98Abnormal hair whorl (HP:0010721)1.89195521
99Cerebral inclusion bodies (HP:0100314)1.87713520
100Abnormality of the pubic bones (HP:0003172)1.87644422
101Hemiplegia (HP:0002301)1.86976439
102Overriding aorta (HP:0002623)1.86227670
103Focal dystonia (HP:0004373)1.85315845
104Morphological abnormality of the pyramidal tract (HP:0002062)1.84512331
105Insidious onset (HP:0003587)1.83436025
106Termporal pattern (HP:0011008)1.83436025
107Gaze-evoked nystagmus (HP:0000640)1.82842828
108Aqueductal stenosis (HP:0002410)1.82683862
109Cutaneous finger syndactyly (HP:0010554)1.81448833
110Inappropriate behavior (HP:0000719)1.80898456
111Obsessive-compulsive behavior (HP:0000722)1.79668036
112Aplasia involving bones of the extremities (HP:0009825)1.78365422
113Aplasia involving bones of the upper limbs (HP:0009823)1.78365422
114Aplasia of the phalanges of the hand (HP:0009802)1.78365422
115Fetal akinesia sequence (HP:0001989)1.78224759
116Abnormality of ocular smooth pursuit (HP:0000617)1.77849812
117Abnormality of the astrocytes (HP:0100707)1.77715820
118Astrocytoma (HP:0009592)1.77715820
119Renovascular hypertension (HP:0100817)1.77654078
120Precocious puberty (HP:0000826)1.76743078
121Abnormality of the hip-girdle musculature (HP:0001445)1.76715792
122Abnormality of the musculature of the pelvis (HP:0001469)1.76715792
123Growth hormone deficiency (HP:0000824)1.76611016
124Apathy (HP:0000741)1.74340526
125Megalocornea (HP:0000485)1.74105576
126Morphological abnormality of the inner ear (HP:0011390)1.73917111
127Akinesia (HP:0002304)1.73856105
128Cutaneous syndactyly (HP:0012725)1.72907401
129Dysmetria (HP:0001310)1.71568961
130High anterior hairline (HP:0009890)1.68450709
131Tracheomalacia (HP:0002779)1.67478337
132Shawl scrotum (HP:0000049)1.66657655
133Septo-optic dysplasia (HP:0100842)1.66544717
134Shallow orbits (HP:0000586)1.65236322
135Dysmetric saccades (HP:0000641)1.64962902
136Narrow nasal bridge (HP:0000446)1.61837676
137Morphological abnormality of the middle ear (HP:0008609)1.60374364
138Rib fusion (HP:0000902)1.58705233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.70355680
2NTRK33.23264219
3MAP3K93.22548502
4KSR12.99693592
5NTRK22.66475419
6MINK12.66270476
7MAP3K42.57476811
8EPHA42.57036671
9SIK32.50094139
10MAPK132.22863383
11DYRK22.21769258
12SIK22.18763092
13MAP2K72.15636076
14EPHB22.13639837
15CDK192.09176163
16PAK62.06625337
17UHMK11.97475919
18ERBB31.90132226
19PNCK1.87463213
20CASK1.80843828
21INSRR1.74159731
22BCR1.69163660
23WNK31.68305727
24DAPK21.67819131
25TRIB31.63044101
26MAP3K121.61351371
27MAP2K41.42323223
28SIK11.40368698
29RIPK11.36903507
30CDK51.36048448
31DAPK11.30836192
32TNIK1.30050124
33PRKCH1.29486886
34PHKG21.28910735
35PHKG11.28910735
36PLK21.25299219
37CAMK1D1.22685860
38ICK1.21900252
39CSNK1G21.20143147
40TYRO31.14032185
41CDK121.10461154
42LATS21.05132520
43DYRK1A1.04174537
44CDK181.03289115
45CSNK1G30.99993162
46FGFR20.98505400
47PRKCG0.98357206
48KSR20.97408315
49CAMK1G0.93863455
50MAPK150.92701123
51CDK140.91736963
52PAK30.91220983
53PRKD30.90741813
54CDK150.90678502
55PRPF4B0.86766770
56CDK11A0.86325669
57CAMKK10.84372940
58MARK20.83287304
59GRK50.79690050
60CSNK1A1L0.79272744
61TNK20.77888749
62PRKCZ0.73206764
63ERBB20.72510874
64SGK2230.72242770
65SGK4940.72242770
66ALK0.69302491
67BMPR1B0.68539348
68RPS6KA20.65915522
69WNK40.64354541
70PKN20.62312785
71MTOR0.62181206
72CCNB10.61732360
73CAMK2A0.60441050
74IRAK20.60433956
75STK110.59133379
76PRKAA10.58774321
77SGK30.58224559
78CSNK1G10.57109083
79NTRK10.56922388
80BRD40.56566759
81MAP3K110.56366182
82LIMK10.55365372
83CAMK10.49727553
84MAPK90.49376276
85RET0.47814396
86DDR20.47757568
87NEK20.47215021
88CAMK2B0.47040954
89SGK10.46573397
90PINK10.45621097
91WNK10.44606174
92ARAF0.42045687
93FER0.41663429
94CAMK40.41188646
95ROCK20.41099391
96FES0.41088167
97PKN10.39682363
98TESK10.38908792
99BRSK10.38189154
100ROCK10.37081473
101SGK20.37015832
102MAP3K60.36812059
103FYN0.36701555
104CSNK1A10.36517035
105PRKD20.36254018
106NME10.36230907
107NEK60.36084390
108PLK30.35944537
109CDC42BPA0.35059184
110RPS6KA60.34607959
111RPS6KC10.34247038
112STK380.33866870
113RAF10.32927357
114CSNK1E0.32575657
115MAP3K100.32555000
116RPS6KA30.31943031
117PRKCE0.31264193
118TAOK10.31008612
119MAPK100.30760207
120CAMKK20.30662304
121MAPK80.30213831
122MAP3K20.28311218
123GSK3B0.28052553
124DMPK0.27942745
125AURKA0.24871987
126PDGFRA0.24152271
127DYRK1B0.23813604

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08730332
2Synaptic vesicle cycle_Homo sapiens_hsa047213.03802877
3GABAergic synapse_Homo sapiens_hsa047272.70037094
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64805073
5Circadian entrainment_Homo sapiens_hsa047132.52470111
6Glutamatergic synapse_Homo sapiens_hsa047242.44752462
7Axon guidance_Homo sapiens_hsa043602.40192766
8Morphine addiction_Homo sapiens_hsa050322.30565808
9Dopaminergic synapse_Homo sapiens_hsa047282.27073800
10Long-term potentiation_Homo sapiens_hsa047202.25360877
11Olfactory transduction_Homo sapiens_hsa047402.19228204
12Amphetamine addiction_Homo sapiens_hsa050312.10899879
13Cholinergic synapse_Homo sapiens_hsa047251.88348837
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86289333
15Insulin secretion_Homo sapiens_hsa049111.82507842
16Cocaine addiction_Homo sapiens_hsa050301.80234436
17Serotonergic synapse_Homo sapiens_hsa047261.67786779
18Taste transduction_Homo sapiens_hsa047421.62097194
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61578478
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61528611
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56823608
22Gap junction_Homo sapiens_hsa045401.55779689
23Long-term depression_Homo sapiens_hsa047301.55258431
24Salivary secretion_Homo sapiens_hsa049701.53668118
25Oxytocin signaling pathway_Homo sapiens_hsa049211.51802828
26Gastric acid secretion_Homo sapiens_hsa049711.37884659
27Renin secretion_Homo sapiens_hsa049241.37747634
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35356793
29GnRH signaling pathway_Homo sapiens_hsa049121.31990498
30Melanogenesis_Homo sapiens_hsa049161.29559875
31ErbB signaling pathway_Homo sapiens_hsa040121.28469426
32Collecting duct acid secretion_Homo sapiens_hsa049661.21171817
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20068381
34Type II diabetes mellitus_Homo sapiens_hsa049301.17140827
35Oocyte meiosis_Homo sapiens_hsa041141.17132973
36Calcium signaling pathway_Homo sapiens_hsa040201.15728733
37Endometrial cancer_Homo sapiens_hsa052131.14717611
38Colorectal cancer_Homo sapiens_hsa052101.14603657
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14308708
40Glioma_Homo sapiens_hsa052141.13838037
41Estrogen signaling pathway_Homo sapiens_hsa049151.13812307
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12102691
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09806013
44Wnt signaling pathway_Homo sapiens_hsa043101.06241013
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03584904
46Vibrio cholerae infection_Homo sapiens_hsa051101.02737329
47cAMP signaling pathway_Homo sapiens_hsa040241.02159838
48Basal cell carcinoma_Homo sapiens_hsa052171.01535197
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01022713
50Hedgehog signaling pathway_Homo sapiens_hsa043400.99968424
51Phototransduction_Homo sapiens_hsa047440.93484088
52Lysine degradation_Homo sapiens_hsa003100.92328837
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.90168275
54VEGF signaling pathway_Homo sapiens_hsa043700.85575770
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85354258
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85268298
57Cardiac muscle contraction_Homo sapiens_hsa042600.84660001
58Choline metabolism in cancer_Homo sapiens_hsa052310.83274823
59Alcoholism_Homo sapiens_hsa050340.82212682
60Renal cell carcinoma_Homo sapiens_hsa052110.80843804
61Hippo signaling pathway_Homo sapiens_hsa043900.80287007
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79003444
63MAPK signaling pathway_Homo sapiens_hsa040100.78431136
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77013071
65mTOR signaling pathway_Homo sapiens_hsa041500.76598219
66Bile secretion_Homo sapiens_hsa049760.75794155
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75386131
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73562880
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73534449
70Notch signaling pathway_Homo sapiens_hsa043300.71309617
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70917937
72AMPK signaling pathway_Homo sapiens_hsa041520.70745317
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69053654
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.68378500
75Vitamin B6 metabolism_Homo sapiens_hsa007500.67473463
76Dorso-ventral axis formation_Homo sapiens_hsa043200.66845680
77Ras signaling pathway_Homo sapiens_hsa040140.64743231
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62950392
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61659581
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61254975
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59631634
82Rap1 signaling pathway_Homo sapiens_hsa040150.58702840
83Dilated cardiomyopathy_Homo sapiens_hsa054140.57914173
84Circadian rhythm_Homo sapiens_hsa047100.55774454
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55340350
86Glucagon signaling pathway_Homo sapiens_hsa049220.54961013
87Insulin signaling pathway_Homo sapiens_hsa049100.54837473
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54389827
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53839942
90Arginine and proline metabolism_Homo sapiens_hsa003300.53142406
91mRNA surveillance pathway_Homo sapiens_hsa030150.52239451
92Non-small cell lung cancer_Homo sapiens_hsa052230.51157786
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51110539
94Inositol phosphate metabolism_Homo sapiens_hsa005620.50777898
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50631226
96Prion diseases_Homo sapiens_hsa050200.50349063
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49416012
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.49399630
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.46739536
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45204644
101Thyroid hormone synthesis_Homo sapiens_hsa049180.43686461
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43183843
103Ovarian steroidogenesis_Homo sapiens_hsa049130.41584204
104Endocytosis_Homo sapiens_hsa041440.40953101
105Prolactin signaling pathway_Homo sapiens_hsa049170.38518282
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37667060
107Pancreatic secretion_Homo sapiens_hsa049720.35309267
108Type I diabetes mellitus_Homo sapiens_hsa049400.34832185
109Adherens junction_Homo sapiens_hsa045200.33470896
110Tight junction_Homo sapiens_hsa045300.32580378
111Steroid biosynthesis_Homo sapiens_hsa001000.32359968
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31690560
113Butanoate metabolism_Homo sapiens_hsa006500.26952776
114beta-Alanine metabolism_Homo sapiens_hsa004100.26622701
115ABC transporters_Homo sapiens_hsa020100.24606072

Most similar genes based on co-expression Upload to Enrichr

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