PRR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.54884234
2pyrimidine nucleobase catabolic process (GO:0006208)4.30905872
3intraciliary transport (GO:0042073)3.91590555
4nonmotile primary cilium assembly (GO:0035058)3.85546080
5response to pheromone (GO:0019236)3.75410522
6protein polyglutamylation (GO:0018095)3.64773106
7presynaptic membrane assembly (GO:0097105)3.60343647
8nucleobase catabolic process (GO:0046113)3.58688900
9protein localization to cilium (GO:0061512)3.56436614
10epithelial cilium movement (GO:0003351)3.56024507
11regulation of cilium movement (GO:0003352)3.53746892
12protein complex biogenesis (GO:0070271)3.42371397
13DNA double-strand break processing (GO:0000729)3.41238548
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33860859
15limb bud formation (GO:0060174)3.31411430
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.29974234
17NADH dehydrogenase complex assembly (GO:0010257)3.29974234
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29974234
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27104693
20presynaptic membrane organization (GO:0097090)3.26910731
21cilium morphogenesis (GO:0060271)3.18850799
22neural tube formation (GO:0001841)3.16708217
23mitochondrial respiratory chain complex assembly (GO:0033108)3.16494355
24cilium organization (GO:0044782)3.13296385
25axoneme assembly (GO:0035082)3.11915287
26water-soluble vitamin biosynthetic process (GO:0042364)3.08703268
27cilium assembly (GO:0042384)3.08148867
28somite development (GO:0061053)3.06174426
29platelet dense granule organization (GO:0060155)2.97436688
30L-fucose catabolic process (GO:0042355)2.95487050
31fucose catabolic process (GO:0019317)2.95487050
32L-fucose metabolic process (GO:0042354)2.95487050
33retinal ganglion cell axon guidance (GO:0031290)2.94918326
34cellular ketone body metabolic process (GO:0046950)2.91738831
35protein-cofactor linkage (GO:0018065)2.91164367
36behavioral response to ethanol (GO:0048149)2.90875219
37respiratory chain complex IV assembly (GO:0008535)2.90396169
38replication fork processing (GO:0031297)2.88337221
39kidney morphogenesis (GO:0060993)2.85478648
40olfactory bulb development (GO:0021772)2.84211608
41cornea development in camera-type eye (GO:0061303)2.83381474
42cilium movement (GO:0003341)2.82489782
43retinal cone cell development (GO:0046549)2.80729800
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80693553
45negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79863662
46glycosphingolipid biosynthetic process (GO:0006688)2.76814681
47protein neddylation (GO:0045116)2.75647383
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75316574
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74361386
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72245775
51regulation of microtubule-based movement (GO:0060632)2.69321230
52positive regulation of amino acid transport (GO:0051957)2.67194902
53cytochrome complex assembly (GO:0017004)2.65776983
54mannosylation (GO:0097502)2.65469849
55cerebral cortex radially oriented cell migration (GO:0021799)2.65436379
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64473237
57indolalkylamine metabolic process (GO:0006586)2.64303004
58forebrain neuron differentiation (GO:0021879)2.63567884
59photoreceptor cell maintenance (GO:0045494)2.62254601
60regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.61458228
61gamma-aminobutyric acid transport (GO:0015812)2.61221378
62neuron cell-cell adhesion (GO:0007158)2.60348863
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.59728553
64regulation of translation, ncRNA-mediated (GO:0045974)2.59728553
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59728553
66synaptic transmission, cholinergic (GO:0007271)2.58930834
67cell proliferation in forebrain (GO:0021846)2.58271431
68positive regulation of mitochondrial fission (GO:0090141)2.58235027
69ketone body metabolic process (GO:1902224)2.57961443
70regulation of telomere maintenance (GO:0032204)2.55898528
71negative regulation of telomere maintenance (GO:0032205)2.55812851
72establishment of protein localization to mitochondrial membrane (GO:0090151)2.53831429
73postsynaptic membrane organization (GO:0001941)2.53333800
74neuron fate determination (GO:0048664)2.52737349
75brain morphogenesis (GO:0048854)2.51602454
76photoreceptor cell development (GO:0042461)2.50719975
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50364749
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50364749
79DNA deamination (GO:0045006)2.50220300
80cullin deneddylation (GO:0010388)2.50053795
81tryptophan catabolic process (GO:0006569)2.49865833
82indole-containing compound catabolic process (GO:0042436)2.49865833
83indolalkylamine catabolic process (GO:0046218)2.49865833
84transmission of nerve impulse (GO:0019226)2.47336025
85hindbrain development (GO:0030902)2.46757229
86ubiquinone metabolic process (GO:0006743)2.46557249
87detection of light stimulus involved in sensory perception (GO:0050962)2.45600913
88detection of light stimulus involved in visual perception (GO:0050908)2.45600913
89resolution of meiotic recombination intermediates (GO:0000712)2.45054874
90neuronal action potential propagation (GO:0019227)2.44017983
91regulation of timing of cell differentiation (GO:0048505)2.43607152
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40370940
93cellular component assembly involved in morphogenesis (GO:0010927)2.39320502
94centriole replication (GO:0007099)2.38625214
95prenylation (GO:0097354)2.38436828
96protein prenylation (GO:0018342)2.38436828
97positive regulation of oligodendrocyte differentiation (GO:0048714)2.37919656
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37607058
99neuronal action potential (GO:0019228)2.37586118
100DNA damage response, detection of DNA damage (GO:0042769)2.37484183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.45420364
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29063021
3GBX2_23144817_ChIP-Seq_PC3_Human3.19466404
4IGF1R_20145208_ChIP-Seq_DFB_Human2.99814313
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80219497
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79040240
7EZH2_22144423_ChIP-Seq_EOC_Human2.77298787
8VDR_22108803_ChIP-Seq_LS180_Human2.70054053
9FUS_26573619_Chip-Seq_HEK293_Human2.53419213
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37087784
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.35004581
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.32559809
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26214547
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23358020
15TAF15_26573619_Chip-Seq_HEK293_Human2.21045326
16EWS_26573619_Chip-Seq_HEK293_Human2.14809840
17P300_19829295_ChIP-Seq_ESCs_Human2.14687350
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07365094
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07189018
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96897165
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.94049741
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92933057
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.92829631
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.84158722
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76706440
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65131583
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.64816870
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64639567
29SMAD4_21799915_ChIP-Seq_A2780_Human1.62114903
30IRF1_19129219_ChIP-ChIP_H3396_Human1.58452504
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58395677
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58036083
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58026911
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56946432
35CBP_20019798_ChIP-Seq_JUKART_Human1.56946432
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56671594
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56671494
38ER_23166858_ChIP-Seq_MCF-7_Human1.54708490
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53141273
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52013694
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.50734413
42RNF2_27304074_Chip-Seq_NSC_Mouse1.49482568
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49229683
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48575270
45BCAT_22108803_ChIP-Seq_LS180_Human1.45071687
46ELK1_19687146_ChIP-ChIP_HELA_Human1.43831277
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43050215
48STAT3_23295773_ChIP-Seq_U87_Human1.42845624
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42601992
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42458061
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42428631
52TP53_22573176_ChIP-Seq_HFKS_Human1.41876361
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41449798
54AR_25329375_ChIP-Seq_VCAP_Human1.40030779
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36570506
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.36442824
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36254868
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35051803
59MYC_18940864_ChIP-ChIP_HL60_Human1.33397881
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32722540
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31949540
62TCF4_23295773_ChIP-Seq_U87_Human1.30563114
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30373195
64REST_21632747_ChIP-Seq_MESCs_Mouse1.27449876
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23995382
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23995382
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23418446
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.20619580
69RUNX2_22187159_ChIP-Seq_PCA_Human1.20559534
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.20034258
71NANOG_19829295_ChIP-Seq_ESCs_Human1.19305386
72SOX2_19829295_ChIP-Seq_ESCs_Human1.19305386
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17447053
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16904356
75TCF4_22108803_ChIP-Seq_LS180_Human1.16424516
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13756337
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13704602
78VDR_23849224_ChIP-Seq_CD4+_Human1.13538165
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11033497
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.10505266
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.09760276
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09117989
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.07046309
84P53_22387025_ChIP-Seq_ESCs_Mouse1.06449570
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05469516
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04711505
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03047316
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.00841334
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00588390
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00153870
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99557625
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.99179057
93NCOR_22424771_ChIP-Seq_293T_Human0.99159671
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.98100551
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.97435376
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.96873829
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95447315
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.94787179
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.94784425
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.94180791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.73905373
2MP0008877_abnormal_DNA_methylation2.73476449
3MP0001529_abnormal_vocalization2.69370418
4MP0003787_abnormal_imprinting2.67579011
5MP0006292_abnormal_olfactory_placode2.63147694
6MP0002102_abnormal_ear_morphology2.56832713
7MP0006072_abnormal_retinal_apoptosis2.38307800
8MP0008789_abnormal_olfactory_epithelium2.25595573
9MP0001984_abnormal_olfaction2.20683206
10MP0003122_maternal_imprinting2.17357173
11MP0005646_abnormal_pituitary_gland2.10687161
12MP0005551_abnormal_eye_electrophysiolog2.00194904
13MP0001968_abnormal_touch/_nociception1.97223778
14MP0000569_abnormal_digit_pigmentation1.96946814
15MP0003121_genomic_imprinting1.94300911
16MP0006276_abnormal_autonomic_nervous1.87879757
17MP0005645_abnormal_hypothalamus_physiol1.87530987
18MP0005394_taste/olfaction_phenotype1.84177545
19MP0005499_abnormal_olfactory_system1.84177545
20MP0000778_abnormal_nervous_system1.83270691
21MP0000631_abnormal_neuroendocrine_gland1.82751682
22MP0002736_abnormal_nociception_after1.82720811
23MP0005253_abnormal_eye_physiology1.81045099
24MP0009046_muscle_twitch1.74993071
25MP0002638_abnormal_pupillary_reflex1.73503513
26MP0002938_white_spotting1.67644928
27MP0002234_abnormal_pharynx_morphology1.65879084
28MP0009745_abnormal_behavioral_response1.63808937
29MP0001486_abnormal_startle_reflex1.59070709
30MP0002272_abnormal_nervous_system1.57542089
31MP0002653_abnormal_ependyma_morphology1.57103979
32MP0004142_abnormal_muscle_tone1.52210934
33MP0000372_irregular_coat_pigmentation1.47643456
34MP0008058_abnormal_DNA_repair1.47211354
35MP0002572_abnormal_emotion/affect_behav1.43566987
36MP0004133_heterotaxia1.41883901
37MP0002837_dystrophic_cardiac_calcinosis1.41279390
38MP0002751_abnormal_autonomic_nervous1.37551761
39MP0000427_abnormal_hair_cycle1.37010955
40MP0002557_abnormal_social/conspecific_i1.35930473
41MP0005423_abnormal_somatic_nervous1.32459158
42MP0003195_calcinosis1.29979657
43MP0005386_behavior/neurological_phenoty1.29920400
44MP0004924_abnormal_behavior1.29920400
45MP0004145_abnormal_muscle_electrophysio1.29116479
46MP0009697_abnormal_copulation1.29085541
47MP0008995_early_reproductive_senescence1.27705032
48MP0008872_abnormal_physiological_respon1.25604678
49MP0003635_abnormal_synaptic_transmissio1.25032737
50MP0002735_abnormal_chemical_nociception1.24223318
51MP0002184_abnormal_innervation1.22878130
52MP0001293_anophthalmia1.22761504
53MP0004885_abnormal_endolymph1.21173846
54MP0002163_abnormal_gland_morphology1.20103996
55MP0003011_delayed_dark_adaptation1.18995954
56MP0005084_abnormal_gallbladder_morpholo1.18940132
57MP0002822_catalepsy1.17909098
58MP0002734_abnormal_mechanical_nocicepti1.17577799
59MP0002876_abnormal_thyroid_physiology1.17274130
60MP0002063_abnormal_learning/memory/cond1.17270842
61MP0001986_abnormal_taste_sensitivity1.14603903
62MP0002233_abnormal_nose_morphology1.14209066
63MP0002064_seizures1.10995902
64MP0002095_abnormal_skin_pigmentation1.10713254
65MP0005195_abnormal_posterior_eye1.08913914
66MP0000647_abnormal_sebaceous_gland1.08377365
67MP0002067_abnormal_sensory_capabilities1.08136882
68MP0005379_endocrine/exocrine_gland_phen1.06527082
69MP0002752_abnormal_somatic_nervous1.06514822
70MP0001970_abnormal_pain_threshold1.06024352
71MP0004043_abnormal_pH_regulation1.05356083
72MP0001501_abnormal_sleep_pattern1.02870340
73MP0001764_abnormal_homeostasis1.02565387
74MP0000516_abnormal_urinary_system1.02435369
75MP0005367_renal/urinary_system_phenotyp1.02435369
76MP0004147_increased_porphyrin_level1.01130971
77MP0004270_analgesia0.98764374
78MP0005391_vision/eye_phenotype0.97346098
79MP0001188_hyperpigmentation0.96598339
80MP0000955_abnormal_spinal_cord0.95503901
81MP0003890_abnormal_embryonic-extraembry0.93207813
82MP0002882_abnormal_neuron_morphology0.92324335
83MP0003937_abnormal_limbs/digits/tail_de0.92175559
84MP0008875_abnormal_xenobiotic_pharmacok0.92007904
85MP0000049_abnormal_middle_ear0.92006529
86MP0001905_abnormal_dopamine_level0.91355189
87MP0000026_abnormal_inner_ear0.91352310
88MP0003698_abnormal_male_reproductive0.91351204
89MP0005075_abnormal_melanosome_morpholog0.90277422
90MP0010386_abnormal_urinary_bladder0.89294521
91MP0002733_abnormal_thermal_nociception0.89238243
92MP0004215_abnormal_myocardial_fiber0.88799393
93MP0001485_abnormal_pinna_reflex0.88744322
94MP0003119_abnormal_digestive_system0.88478992
95MP0003718_maternal_effect0.86773227
96MP0003646_muscle_fatigue0.84749665
97MP0005174_abnormal_tail_pigmentation0.84494144
98MP0001929_abnormal_gametogenesis0.80788432
99MP0003938_abnormal_ear_development0.79772965
100MP0009780_abnormal_chondrocyte_physiolo0.78191425

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.18691162
2Pancreatic cysts (HP:0001737)3.97951905
3Nephronophthisis (HP:0000090)3.97908097
4Abnormality of midbrain morphology (HP:0002418)3.90128312
5Molar tooth sign on MRI (HP:0002419)3.90128312
6True hermaphroditism (HP:0010459)3.88224863
7Medial flaring of the eyebrow (HP:0010747)3.80499361
8Abnormality of the renal medulla (HP:0100957)3.42207097
9Gait imbalance (HP:0002141)3.34322224
10Congenital primary aphakia (HP:0007707)3.22675353
11Intestinal atresia (HP:0011100)3.16266029
12Hyperventilation (HP:0002883)3.11443080
13Abnormality of the labia minora (HP:0012880)3.09611176
14Chronic hepatic failure (HP:0100626)3.02957795
15Acute necrotizing encephalopathy (HP:0006965)2.98434241
16Nephrogenic diabetes insipidus (HP:0009806)2.97119670
17Abnormality of the renal cortex (HP:0011035)2.77905885
18Genital tract atresia (HP:0001827)2.74486681
19Progressive macrocephaly (HP:0004481)2.72737232
20Aplasia/Hypoplasia of the tongue (HP:0010295)2.62980283
21Vaginal atresia (HP:0000148)2.61620478
223-Methylglutaconic aciduria (HP:0003535)2.58797134
23Acute encephalopathy (HP:0006846)2.58167032
24Mitochondrial inheritance (HP:0001427)2.54182412
25Cystic liver disease (HP:0006706)2.52766121
26Volvulus (HP:0002580)2.50108497
27Postaxial foot polydactyly (HP:0001830)2.48037069
28Congenital stationary night blindness (HP:0007642)2.47880870
29Abnormal mitochondria in muscle tissue (HP:0008316)2.46997896
30Abolished electroretinogram (ERG) (HP:0000550)2.41626557
31Abnormal rod and cone electroretinograms (HP:0008323)2.40174727
32Increased CSF lactate (HP:0002490)2.37985857
33Postaxial hand polydactyly (HP:0001162)2.36263949
34Sclerocornea (HP:0000647)2.34902262
35Broad-based gait (HP:0002136)2.34208625
36Type II lissencephaly (HP:0007260)2.33763165
37Hepatocellular necrosis (HP:0001404)2.30587522
38Colon cancer (HP:0003003)2.30118228
39Methylmalonic acidemia (HP:0002912)2.29002651
40Polyphagia (HP:0002591)2.25195704
41Poor coordination (HP:0002370)2.24161432
42Pendular nystagmus (HP:0012043)2.24010075
43Attenuation of retinal blood vessels (HP:0007843)2.23973072
44Oligodactyly (hands) (HP:0001180)2.23692334
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.23543350
46Lissencephaly (HP:0001339)2.21649052
47Anencephaly (HP:0002323)2.19739516
48Congenital hepatic fibrosis (HP:0002612)2.17125913
49Renal cortical cysts (HP:0000803)2.16990292
50Tubulointerstitial nephritis (HP:0001970)2.04279959
51Gastrointestinal atresia (HP:0002589)2.03863808
52Hepatic necrosis (HP:0002605)2.03689415
53Short tibia (HP:0005736)2.02557468
54Narrow forehead (HP:0000341)2.02469567
55Hypothermia (HP:0002045)2.01761655
56Optic nerve hypoplasia (HP:0000609)2.00889062
57Focal motor seizures (HP:0011153)1.99079936
58Tubular atrophy (HP:0000092)1.98486013
59Male pseudohermaphroditism (HP:0000037)1.97561267
60Drooling (HP:0002307)1.97535117
61Occipital encephalocele (HP:0002085)1.96781378
62Cerebellar dysplasia (HP:0007033)1.95805277
63Bile duct proliferation (HP:0001408)1.94890331
64Abnormal biliary tract physiology (HP:0012439)1.94890331
65Optic disc pallor (HP:0000543)1.92816912
66Absent speech (HP:0001344)1.92475251
67Specific learning disability (HP:0001328)1.91782103
68Abnormal drinking behavior (HP:0030082)1.91640907
69Polydipsia (HP:0001959)1.91640907
70Preaxial hand polydactyly (HP:0001177)1.91042436
71Increased corneal curvature (HP:0100692)1.88789091
72Keratoconus (HP:0000563)1.88789091
73Pachygyria (HP:0001302)1.88779113
74Hyperglycinemia (HP:0002154)1.86836303
75Methylmalonic aciduria (HP:0012120)1.86824776
76Broad foot (HP:0001769)1.85564837
77Inability to walk (HP:0002540)1.84530370
78Cerebral edema (HP:0002181)1.82712754
79Growth hormone deficiency (HP:0000824)1.82137229
80Severe visual impairment (HP:0001141)1.81811288
81Thyroid-stimulating hormone excess (HP:0002925)1.80793601
82Bony spicule pigmentary retinopathy (HP:0007737)1.80686367
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77479513
84Prominent nasal bridge (HP:0000426)1.76082285
85Aganglionic megacolon (HP:0002251)1.75825669
86Progressive cerebellar ataxia (HP:0002073)1.75662430
87Dandy-Walker malformation (HP:0001305)1.75478225
88Multicystic kidney dysplasia (HP:0000003)1.75196438
89Abnormality of the metopic suture (HP:0005556)1.74852075
90Decreased testicular size (HP:0008734)1.74746436
91Retinal dysplasia (HP:0007973)1.73626443
92Excessive salivation (HP:0003781)1.72997266
93Lipid accumulation in hepatocytes (HP:0006561)1.71862968
94Hemiparesis (HP:0001269)1.71800087
95Tented upper lip vermilion (HP:0010804)1.70834855
96Neoplasm of the adrenal cortex (HP:0100641)1.70788248
97Decreased central vision (HP:0007663)1.69286696
98Astigmatism (HP:0000483)1.68945308
99Increased hepatocellular lipid droplets (HP:0006565)1.68764942
100Furrowed tongue (HP:0000221)1.68736633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.57068135
2FRK3.51625855
3CASK2.78995035
4MAP3K42.77771651
5WNK32.70866567
6NUAK12.42334098
7MAPK132.16516301
8MARK12.16262021
9BMPR1B2.06755842
10MAP2K72.01228615
11PINK11.91037484
12INSRR1.89805313
13ZAK1.75538274
14ADRBK21.67881282
15TRIM281.61145530
16EPHA41.58546467
17DYRK21.53422990
18GRK11.51602469
19BCKDK1.50703413
20ERBB31.46328839
21TAOK31.45212586
22TNIK1.44458242
23BCR1.39751212
24PLK41.22507449
25PLK21.22059383
26MKNK21.21797042
27VRK11.17855768
28CSNK1G11.17352136
29CSNK1G21.16719956
30CSNK1G31.15535724
31PAK31.12154761
32STK391.08037730
33PNCK1.05504575
34WNK41.03489150
35CSNK1A1L1.01037682
36ACVR1B0.96351705
37OXSR10.95570202
38TLK10.91532867
39MKNK10.90747622
40EIF2AK30.90669375
41PRKCE0.88895275
42SRPK10.88007414
43DYRK30.84226044
44NTRK20.84063498
45NTRK30.82013296
46PRKCG0.80620600
47FGFR20.79705609
48NME10.79171762
49LATS10.78235548
50PHKG20.75544121
51PHKG10.75544121
52PLK30.72717442
53MST40.72184805
54EPHA30.64099887
55MINK10.62597813
56STK38L0.62235796
57MAPK150.61323438
58VRK20.59117323
59OBSCN0.56065490
60MAP2K40.55833385
61DAPK20.55783135
62CDK190.54226076
63ADRBK10.53914839
64CCNB10.52090439
65STK160.49278610
66RPS6KA40.48115788
67PKN10.48042665
68PBK0.45729186
69CSNK1A10.45585216
70CAMK2A0.45584089
71CDK30.45347062
72DYRK1A0.44904706
73AKT30.44048955
74PLK10.43762181
75RPS6KA50.43702646
76CAMK10.43590297
77BRSK20.43461652
78TGFBR10.39342266
79MUSK0.38807178
80PRKACA0.37348710
81STK30.37306120
82WEE10.37170345
83EPHB20.36789295
84ATM0.36689183
85PRKG10.33259543
86CAMKK20.32797511
87FLT30.31985476
88TIE10.31544993
89IRAK10.30576249
90PIK3CA0.30566848
91PRKD30.30495205
92PTK2B0.30458933
93CSNK1D0.30362888
94ATR0.29355282
95LIMK10.29275431
96SGK20.27403741
97CAMK40.27399400
98FER0.27276082
99TEC0.26732487
100CAMK2D0.26590599

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36099630
2Protein export_Homo sapiens_hsa030602.74347207
3Oxidative phosphorylation_Homo sapiens_hsa001902.73245426
4Phototransduction_Homo sapiens_hsa047442.53039508
5Butanoate metabolism_Homo sapiens_hsa006502.48234628
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46873131
7Nicotine addiction_Homo sapiens_hsa050332.34603127
8Parkinsons disease_Homo sapiens_hsa050122.22594500
9RNA polymerase_Homo sapiens_hsa030202.05022465
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04146457
11Propanoate metabolism_Homo sapiens_hsa006402.02064896
12Fanconi anemia pathway_Homo sapiens_hsa034601.99813983
13Basal transcription factors_Homo sapiens_hsa030221.99379029
14Steroid biosynthesis_Homo sapiens_hsa001001.96180204
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91487778
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89346429
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83348731
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82752829
19Homologous recombination_Homo sapiens_hsa034401.59811037
20Huntingtons disease_Homo sapiens_hsa050161.59655283
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59495089
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.54499546
23RNA degradation_Homo sapiens_hsa030181.52967157
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45805351
25Linoleic acid metabolism_Homo sapiens_hsa005911.43652588
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43145699
27Alzheimers disease_Homo sapiens_hsa050101.39370567
28Nitrogen metabolism_Homo sapiens_hsa009101.38094127
29Taste transduction_Homo sapiens_hsa047421.34060881
30Regulation of autophagy_Homo sapiens_hsa041401.32060062
31Ether lipid metabolism_Homo sapiens_hsa005651.29757792
32Tryptophan metabolism_Homo sapiens_hsa003801.27220953
33Olfactory transduction_Homo sapiens_hsa047401.24426962
34Peroxisome_Homo sapiens_hsa041461.22622157
35Non-homologous end-joining_Homo sapiens_hsa034501.21057019
36Fatty acid elongation_Homo sapiens_hsa000621.19368407
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18963201
38GABAergic synapse_Homo sapiens_hsa047271.18188084
39Salivary secretion_Homo sapiens_hsa049701.14277233
40Cardiac muscle contraction_Homo sapiens_hsa042601.14024155
41Selenocompound metabolism_Homo sapiens_hsa004501.10217222
42Morphine addiction_Homo sapiens_hsa050321.09819099
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08688131
44Glutamatergic synapse_Homo sapiens_hsa047241.04511731
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03036661
46Proteasome_Homo sapiens_hsa030501.02294967
47Circadian entrainment_Homo sapiens_hsa047131.00940421
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00164461
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99889374
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.96927967
51Collecting duct acid secretion_Homo sapiens_hsa049660.95377969
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93269011
53Insulin secretion_Homo sapiens_hsa049110.92969749
54Chemical carcinogenesis_Homo sapiens_hsa052040.92616475
55Purine metabolism_Homo sapiens_hsa002300.92549316
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.87982204
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87946466
58Retinol metabolism_Homo sapiens_hsa008300.83873057
59Dopaminergic synapse_Homo sapiens_hsa047280.81225875
60Base excision repair_Homo sapiens_hsa034100.80042182
61Fatty acid metabolism_Homo sapiens_hsa012120.79509315
62Mismatch repair_Homo sapiens_hsa034300.77112582
63Serotonergic synapse_Homo sapiens_hsa047260.76991453
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76430449
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76396408
66Nucleotide excision repair_Homo sapiens_hsa034200.76175014
67Hedgehog signaling pathway_Homo sapiens_hsa043400.74724963
68Pyrimidine metabolism_Homo sapiens_hsa002400.73244977
69Circadian rhythm_Homo sapiens_hsa047100.72963779
70Cocaine addiction_Homo sapiens_hsa050300.72460756
71Metabolic pathways_Homo sapiens_hsa011000.70892227
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70369722
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67802806
74beta-Alanine metabolism_Homo sapiens_hsa004100.67200060
75Amphetamine addiction_Homo sapiens_hsa050310.63626951
76Caffeine metabolism_Homo sapiens_hsa002320.62914229
77Fatty acid degradation_Homo sapiens_hsa000710.62638519
78RNA transport_Homo sapiens_hsa030130.61024666
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57613839
80One carbon pool by folate_Homo sapiens_hsa006700.56761608
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54482162
82Arachidonic acid metabolism_Homo sapiens_hsa005900.53785994
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51863408
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50349642
85Basal cell carcinoma_Homo sapiens_hsa052170.50329448
86Long-term depression_Homo sapiens_hsa047300.48468965
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.46479276
88Axon guidance_Homo sapiens_hsa043600.45806588
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45341644
90Ovarian steroidogenesis_Homo sapiens_hsa049130.44420926
91Spliceosome_Homo sapiens_hsa030400.44205315
92Oocyte meiosis_Homo sapiens_hsa041140.42492600
93Pyruvate metabolism_Homo sapiens_hsa006200.41995622
94ABC transporters_Homo sapiens_hsa020100.41524409
95Fat digestion and absorption_Homo sapiens_hsa049750.40711929
96Synaptic vesicle cycle_Homo sapiens_hsa047210.39429893
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38601970
98Alcoholism_Homo sapiens_hsa050340.38180232
99Calcium signaling pathway_Homo sapiens_hsa040200.37908183
100Renin secretion_Homo sapiens_hsa049240.33860453

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