PRR5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.38914588
2ensheathment of neurons (GO:0007272)6.68028319
3axon ensheathment (GO:0008366)6.68028319
4long-chain fatty acid biosynthetic process (GO:0042759)6.67837836
5myelination (GO:0042552)6.67038462
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.31690087
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.90618568
8negative regulation of cell killing (GO:0031342)5.90618568
9myelin maintenance (GO:0043217)5.87833895
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.79134682
11positive regulation of gamma-delta T cell activation (GO:0046645)5.48362316
12amyloid precursor protein metabolic process (GO:0042982)5.48197805
13antigen processing and presentation of endogenous antigen (GO:0019883)5.44149712
14cholesterol biosynthetic process (GO:0006695)5.42924756
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26874907
16response to methylmercury (GO:0051597)5.16974827
17negative regulation of neurotransmitter transport (GO:0051589)5.08582207
18sterol biosynthetic process (GO:0016126)4.93285880
19negative regulation of neurotransmitter secretion (GO:0046929)4.87858787
20negative regulation of protein localization to cell surface (GO:2000009)4.86119556
21regulation of B cell receptor signaling pathway (GO:0050855)4.84954172
22positive regulation of oligodendrocyte differentiation (GO:0048714)4.75051874
23isoprenoid biosynthetic process (GO:0008299)4.62874968
24establishment of mitochondrion localization (GO:0051654)4.61536519
25regulation of lipoprotein metabolic process (GO:0050746)4.48416806
26response to lipoprotein particle (GO:0055094)4.43834854
27positive regulation by symbiont of host defense response (GO:0052509)4.33667753
28modulation by symbiont of host defense response (GO:0052031)4.33667753
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.33667753
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.33667753
31positive regulation by organism of defense response of other organism involved in symbiotic interact4.33667753
32modulation by symbiont of host immune response (GO:0052553)4.33667753
33regulation of collateral sprouting (GO:0048670)4.29833563
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.24111412
35creatine metabolic process (GO:0006600)4.16146699
36detection of other organism (GO:0098543)4.16055923
37amyloid precursor protein catabolic process (GO:0042987)4.13454668
38long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.08201898
39L-amino acid import (GO:0043092)4.07399456
40negative regulation of interleukin-12 production (GO:0032695)3.98207139
41detection of bacterium (GO:0016045)3.96167147
42long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.94328963
43regulation of gamma-delta T cell activation (GO:0046643)3.92557178
44eye photoreceptor cell differentiation (GO:0001754)3.91335134
45photoreceptor cell differentiation (GO:0046530)3.91335134
46glycerophospholipid catabolic process (GO:0046475)3.90412153
47GPI anchor biosynthetic process (GO:0006506)3.85746988
48oligodendrocyte differentiation (GO:0048709)3.81737876
49response to interleukin-15 (GO:0070672)3.78506017
50import into cell (GO:0098657)3.78335274
51apical protein localization (GO:0045176)3.74774194
52macrophage activation involved in immune response (GO:0002281)3.72075345
53positive thymic T cell selection (GO:0045059)3.70269169
54cellular response to interleukin-15 (GO:0071350)3.69759538
55regulation of gamma-delta T cell differentiation (GO:0045586)3.67783198
56asymmetric protein localization (GO:0008105)3.65609325
57activated T cell proliferation (GO:0050798)3.65535908
58leukocyte aggregation (GO:0070486)3.65250906
59GPI anchor metabolic process (GO:0006505)3.60823391
60negative regulation of lymphocyte mediated immunity (GO:0002707)3.58678961
61astrocyte development (GO:0014002)3.58189639
62immunoglobulin mediated immune response (GO:0016064)3.56753197
63negative thymic T cell selection (GO:0045060)3.54861004
64neutrophil activation (GO:0042119)3.52231799
65negative T cell selection (GO:0043383)3.51383499
66fatty-acyl-CoA biosynthetic process (GO:0046949)3.43352068
67cellular extravasation (GO:0045123)3.41693917
68negative regulation of leukocyte mediated immunity (GO:0002704)3.39035896
69detection of external biotic stimulus (GO:0098581)3.38962189
70fatty-acyl-CoA metabolic process (GO:0035337)3.38726176
71response to type I interferon (GO:0034340)3.35917352
72neuron remodeling (GO:0016322)3.34906992
73cellular response to type I interferon (GO:0071357)3.34697174
74type I interferon signaling pathway (GO:0060337)3.34697174
75response to redox state (GO:0051775)3.34501251
76presynaptic membrane organization (GO:0097090)3.30905016
77very long-chain fatty acid metabolic process (GO:0000038)3.30665535
78axon development (GO:0061564)3.30338885
79protein neddylation (GO:0045116)3.29624050
80regulation of tolerance induction (GO:0002643)3.29276093
81protein palmitoylation (GO:0018345)3.29172779
82regulation of T cell mediated cytotoxicity (GO:0001914)3.28011864
83membrane tubulation (GO:0097320)3.27531527
84regulation of T cell tolerance induction (GO:0002664)3.27447796
85response to peptidoglycan (GO:0032494)3.27325944
86negative regulation of execution phase of apoptosis (GO:1900118)3.26437276
87granulocyte activation (GO:0036230)3.24590764
88preassembly of GPI anchor in ER membrane (GO:0016254)3.23998025
89positive regulation of T cell mediated cytotoxicity (GO:0001916)3.23418217
90antigen processing and presentation via MHC class Ib (GO:0002475)3.22524901
91positive regulation of glial cell differentiation (GO:0045687)3.21505727
92regulation of interferon-beta biosynthetic process (GO:0045357)3.20526810
93regulation of B cell differentiation (GO:0045577)3.20236560
94membrane raft organization (GO:0031579)3.19938377
95leukocyte migration involved in inflammatory response (GO:0002523)3.19937442
96regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19475079
97detection of molecule of bacterial origin (GO:0032490)3.18994794
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.17169156
99regulation of natural killer cell mediated immunity (GO:0002715)3.17169156
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17138409
101response to host immune response (GO:0052572)3.17138409
102magnesium ion transport (GO:0015693)3.15554234
103substantia nigra development (GO:0021762)3.12806500
104glycosylceramide metabolic process (GO:0006677)3.12460713
105positive regulation of tolerance induction (GO:0002645)3.12142765
106tissue regeneration (GO:0042246)3.11866333
107negative regulation of T cell mediated immunity (GO:0002710)3.09602707
108detection of biotic stimulus (GO:0009595)3.09445195
109positive T cell selection (GO:0043368)3.09434381
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05117321
111response to host (GO:0075136)3.05117321
112response to host defenses (GO:0052200)3.05117321
113response to muramyl dipeptide (GO:0032495)3.02999451
114positive regulation of gliogenesis (GO:0014015)3.01775987
115negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.01657874
116microglial cell activation (GO:0001774)3.01494570
117peptidyl-tyrosine autophosphorylation (GO:0038083)2.99930012
118neutrophil activation involved in immune response (GO:0002283)2.98198525
119regulation of mast cell degranulation (GO:0043304)2.97862316
120limb bud formation (GO:0060174)2.97346984
121regulation of regulatory T cell differentiation (GO:0045589)2.97097566
122myeloid cell activation involved in immune response (GO:0002275)2.96085850
123dendritic cell chemotaxis (GO:0002407)2.96030718
124T cell migration (GO:0072678)2.95102667
125dendritic cell migration (GO:0036336)2.94867193
126cerebral cortex radially oriented cell migration (GO:0021799)2.93285865
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93114768
128regulation of leukocyte mediated cytotoxicity (GO:0001910)2.90472146
129positive regulation of pseudopodium assembly (GO:0031274)2.90452434
130amino acid import (GO:0043090)2.90134671
131respiratory burst (GO:0045730)2.89485001
132organ growth (GO:0035265)2.88652969
133interferon-gamma-mediated signaling pathway (GO:0060333)2.86497899
134regulation of alpha-beta T cell proliferation (GO:0046640)2.85423572
135B cell receptor signaling pathway (GO:0050853)2.85289850
136negative regulation of chemokine production (GO:0032682)2.84811983
137NIK/NF-kappaB signaling (GO:0038061)2.84553146
138positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84198922
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82593532
140negative regulation of innate immune response (GO:0045824)2.82518341
141positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.81948075
142positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80126313
143regulation of leukocyte degranulation (GO:0043300)2.80080813
144T cell selection (GO:0045058)2.79270260
145thymic T cell selection (GO:0045061)2.79265065
146regulation of mast cell activation involved in immune response (GO:0033006)2.78280997
147negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76519474
148positive regulation of B cell differentiation (GO:0045579)2.74322644
149regulation of antigen processing and presentation (GO:0002577)2.74235473
150tolerance induction (GO:0002507)2.73413551
151neurotransmitter uptake (GO:0001504)2.73284734
152germinal center formation (GO:0002467)2.72923374
153defense response to protozoan (GO:0042832)2.72786573
154positive regulation of interleukin-17 production (GO:0032740)2.70982103
155adult walking behavior (GO:0007628)2.70505015
156positive regulation of antigen processing and presentation (GO:0002579)2.70244923
157extracellular matrix assembly (GO:0085029)2.69981031
158nerve growth factor signaling pathway (GO:0038180)2.69357601
159interleukin-6-mediated signaling pathway (GO:0070102)2.68670723
160macrophage activation (GO:0042116)2.68549915
161myelination in peripheral nervous system (GO:0022011)2.68474968
162peripheral nervous system axon ensheathment (GO:0032292)2.68474968
163adhesion of symbiont to host cell (GO:0044650)2.68268312
164virion attachment to host cell (GO:0019062)2.68268312
165B cell mediated immunity (GO:0019724)2.66268845
166positive regulation of mast cell activation (GO:0033005)2.65141137
167lipopolysaccharide-mediated signaling pathway (GO:0031663)2.63770664
168regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63082205
169positive regulation of cellular amine metabolic process (GO:0033240)2.61929021
170positive regulation of granulocyte differentiation (GO:0030854)2.61660959
171detection of temperature stimulus involved in sensory perception (GO:0050961)2.61548087
172detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.61548087
173regulation of cell killing (GO:0031341)2.60988256
174regulation of necroptotic process (GO:0060544)2.60875683
175regulation of mast cell activation (GO:0033003)2.60870876
176positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.60345047
177microtubule polymerization or depolymerization (GO:0031109)2.59852647
178leukocyte degranulation (GO:0043299)2.58758967
179mannosylation (GO:0097502)2.57817264
180negative regulation of JUN kinase activity (GO:0043508)2.57008298
181positive regulation of toll-like receptor signaling pathway (GO:0034123)2.56735923
182presynaptic membrane assembly (GO:0097105)2.56613134
183enteric nervous system development (GO:0048484)2.55826860
184Golgi to endosome transport (GO:0006895)2.55279715
185positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.53398915
186heme transport (GO:0015886)2.52708237
187regulation of pseudopodium assembly (GO:0031272)2.51369402
188iron coordination entity transport (GO:1901678)2.50933482
189cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.50813637
190negative regulation of acute inflammatory response (GO:0002674)2.50290881
191nucleotide transmembrane transport (GO:1901679)2.50235891
192glial cell development (GO:0021782)2.50116093
193regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.50004723
194alcohol biosynthetic process (GO:0046165)2.49963714
195thioester biosynthetic process (GO:0035384)2.49733779
196acyl-CoA biosynthetic process (GO:0071616)2.49733779
197regulation of somitogenesis (GO:0014807)2.49723215
198central nervous system myelination (GO:0022010)12.9502590
199axon ensheathment in central nervous system (GO:0032291)12.9502590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.89009903
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.27232533
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.78941589
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.24765590
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07267653
6RUNX_20019798_ChIP-Seq_JUKART_Human2.95462731
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81082080
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76087454
9GBX2_23144817_ChIP-Seq_PC3_Human2.75108756
10* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.65733732
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58263085
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.53546849
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42510452
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40122933
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35047749
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.33530267
17VDR_24763502_ChIP-Seq_THP-1_Human2.26767428
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25693551
19MYB_26560356_Chip-Seq_TH2_Human2.21958829
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19508349
21SPI1_23127762_ChIP-Seq_K562_Human2.17136657
22SCL_19346495_ChIP-Seq_HPC-7_Human2.14209285
23VDR_21846776_ChIP-Seq_THP-1_Human2.10495633
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08574510
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07407979
26TAF15_26573619_Chip-Seq_HEK293_Human2.06386916
27CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05445418
28* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04875052
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01808357
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01400792
31SPI1_23547873_ChIP-Seq_NB4_Human2.01290636
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.92206652
33MAF_26560356_Chip-Seq_TH1_Human1.91552969
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88240028
35ER_23166858_ChIP-Seq_MCF-7_Human1.87260832
36VDR_24787735_ChIP-Seq_THP-1_Human1.86742804
37MYB_26560356_Chip-Seq_TH1_Human1.84137107
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84132297
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83458354
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.83269250
41UTX_26944678_Chip-Seq_JUKART_Human1.83108546
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81692722
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76959232
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76702573
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76638987
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76424936
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.74436943
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73827040
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70548661
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70289191
51VDR_22108803_ChIP-Seq_LS180_Human1.69271032
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67495203
53TCF7_22412390_ChIP-Seq_EML_Mouse1.63965592
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61928338
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60804228
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.59288289
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58406615
58GATA3_27048872_Chip-Seq_THYMUS_Human1.54160465
59AR_21572438_ChIP-Seq_LNCaP_Human1.53939840
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53586634
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52890858
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51555513
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51083974
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48760561
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48664896
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48664896
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.47466529
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46690238
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46690238
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.45859814
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45312922
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44730833
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.44718376
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44505272
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39088659
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38636665
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.38081307
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37360718
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.37114026
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36426305
81MAF_26560356_Chip-Seq_TH2_Human1.34148721
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33969604
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.33333031
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31773144
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.31472622
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30712160
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30236978
88* KDM2B_26808549_Chip-Seq_DND41_Human1.29292496
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28992061
90* CMYC_18555785_Chip-Seq_ESCs_Mouse1.28299624
91* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26427908
92GATA1_19941826_ChIP-Seq_K562_Human1.25960759
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25187725
94P300_19829295_ChIP-Seq_ESCs_Human1.25182858
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24803677
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24746093
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23474116
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23451819
99MYC_22102868_ChIP-Seq_BL_Human1.23315478
100* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22934845
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.22911691
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22885116
103TAL1_26923725_Chip-Seq_HPCs_Mouse1.22756694
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.22400016
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22282655
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22190957
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21511197
108* NANOG_18555785_Chip-Seq_ESCs_Mouse1.20653575
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20581099
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18759110
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16194285
112TP63_17297297_ChIP-ChIP_HaCaT_Human1.15834196
113* P300_18555785_Chip-Seq_ESCs_Mouse1.15636474
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15561514
115EZH2_22144423_ChIP-Seq_EOC_Human1.14939133
116GATA3_26560356_Chip-Seq_TH2_Human1.14484588
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.14033462
118IGF1R_20145208_ChIP-Seq_DFB_Human1.13894051
119FUS_26573619_Chip-Seq_HEK293_Human1.13020088
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12952124
121EP300_21415370_ChIP-Seq_HL-1_Mouse1.12035342
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10894422
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10730270
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10545178
125EOMES_21245162_ChIP-Seq_HESCs_Human1.10078473
126* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10044742
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09990183
128EGR1_19374776_ChIP-ChIP_THP-1_Human1.09304866
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08675210
130* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08580075
131GATA1_22025678_ChIP-Seq_K562_Human1.07982788
132PU_27001747_Chip-Seq_BMDM_Mouse1.07777732
133* STAT3_18555785_Chip-Seq_ESCs_Mouse1.07401716
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07078690
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06719808
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06601024
137PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06546288
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05113629
139GATA2_19941826_ChIP-Seq_K562_Human1.04042619
140* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02501957
141HTT_18923047_ChIP-ChIP_STHdh_Human1.02445195
142SOX2_19829295_ChIP-Seq_ESCs_Human1.02220168
143NANOG_19829295_ChIP-Seq_ESCs_Human1.02220168
144PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01857861
145* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01443043
146IRF8_27001747_Chip-Seq_BMDM_Mouse1.01332187
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00705850
148GATA2_21666600_ChIP-Seq_HMVEC_Human1.00694635
149* KLF4_18555785_Chip-Seq_ESCs_Mouse1.00543629
150GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00067817
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00045497
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99978781
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99506686
154* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98297911
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.98271436
156* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98179141
157LXR_22292898_ChIP-Seq_THP-1_Human0.97633039
158GATA1_26923725_Chip-Seq_HPCs_Mouse0.97167271
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97071944
160SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96928710
161* P53_22387025_ChIP-Seq_ESCs_Mouse0.96372560
162CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96234850
163* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95123938
164* STAT3_23295773_ChIP-Seq_U87_Human0.95067426
165ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94615831
166KDM2B_26808549_Chip-Seq_JURKAT_Human0.94303800
167* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94201133
168KDM2B_26808549_Chip-Seq_REH_Human0.93358892
169ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93069499
170SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92760261
171FLI1_27457419_Chip-Seq_LIVER_Mouse0.91080882
172SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90353184
173P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89277705
174RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89120553
175GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89074056
176TP53_16413492_ChIP-PET_HCT116_Human0.88919637
177CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88865997
178HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88071197
179SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87872581
180* PU1_27457419_Chip-Seq_LIVER_Mouse0.87660159
181GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87232407
182ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87101876
183PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86893604
184CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86136495
185VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83599731
186BCOR_27268052_Chip-Seq_Bcells_Human0.83136257
187RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82014541
188ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81057873
189BCL6_27268052_Chip-Seq_Bcells_Human0.79806714
190JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79396309
191FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78730091
192PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77406371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination6.18585666
2MP0003950_abnormal_plasma_membrane4.50091179
3MP0003436_decreased_susceptibility_to3.98633337
4MP0003690_abnormal_glial_cell3.43189032
5MP0003303_peritoneal_inflammation3.09517953
6MP0003880_abnormal_central_pattern2.88099462
7MP0003763_abnormal_thymus_physiology2.75116553
8MP0001800_abnormal_humoral_immune2.69883874
9MP0004742_abnormal_vestibular_system2.69760554
10MP0005025_abnormal_response_to2.67544892
11MP0003300_gastrointestinal_ulcer2.66613754
12MP0001529_abnormal_vocalization2.62588636
13MP0003329_amyloid_beta_deposits2.61421955
14MP0005171_absent_coat_pigmentation2.58953414
15MP0001905_abnormal_dopamine_level2.52005646
16MP0003136_yellow_coat_color2.48738537
17MP0000685_abnormal_immune_system2.47475538
18MP0002723_abnormal_immune_serum2.41137817
19MP0002420_abnormal_adaptive_immunity2.40481443
20MP0005409_darkened_coat_color2.39978786
21MP0001819_abnormal_immune_cell2.39906114
22MP0002452_abnormal_antigen_presenting2.35893287
23MP0010155_abnormal_intestine_physiology2.34950463
24MP0003634_abnormal_glial_cell2.30898206
25MP0004270_analgesia2.26913378
26MP0006082_CNS_inflammation2.15649566
27MP0001533_abnormal_skeleton_physiology2.15143663
28MP0003866_abnormal_defecation2.14595208
29MP0005451_abnormal_body_composition2.13909009
30MP0001486_abnormal_startle_reflex2.13093948
31MP0008260_abnormal_autophagy2.12707877
32MP0010678_abnormal_skin_adnexa2.08366270
33MP0002272_abnormal_nervous_system2.07591213
34MP0005464_abnormal_platelet_physiology2.05601879
35MP0004142_abnormal_muscle_tone2.04823111
36MP0004885_abnormal_endolymph1.99351714
37MP0003183_abnormal_peptide_metabolism1.99176294
38MP0005058_abnormal_lysosome_morphology1.98815785
39MP0003191_abnormal_cellular_cholesterol1.96947313
40MP0002405_respiratory_system_inflammati1.95349552
41MP0005410_abnormal_fertilization1.94676573
42MP0003632_abnormal_nervous_system1.89154962
43MP0000383_abnormal_hair_follicle1.88544637
44MP0003828_pulmonary_edema1.88407540
45MP0001346_abnormal_lacrimal_gland1.87935265
46MP0009333_abnormal_splenocyte_physiolog1.82548623
47MP0000716_abnormal_immune_system1.80045957
48MP0002396_abnormal_hematopoietic_system1.79876562
49MP0002398_abnormal_bone_marrow1.79242342
50MP0001485_abnormal_pinna_reflex1.76600327
51MP0004134_abnormal_chest_morphology1.75639009
52MP0001845_abnormal_inflammatory_respons1.69314075
53MP0000778_abnormal_nervous_system1.67561241
54MP0003631_nervous_system_phenotype1.67449308
55MP0000604_amyloidosis1.66244723
56MP0004947_skin_inflammation1.65629966
57MP0003806_abnormal_nucleotide_metabolis1.63528425
58MP0005423_abnormal_somatic_nervous1.60351428
59MP0002229_neurodegeneration1.60098631
60MP0004381_abnormal_hair_follicle1.57663548
61MP0003633_abnormal_nervous_system1.56897958
62MP0002064_seizures1.55899160
63MP0004043_abnormal_pH_regulation1.53779664
64MP0000858_altered_metastatic_potential1.46421023
65MP0001851_eye_inflammation1.45005447
66MP0002998_abnormal_bone_remodeling1.44665090
67MP0003448_altered_tumor_morphology1.42658349
68MP0002429_abnormal_blood_cell1.42088465
69MP0001958_emphysema1.41743949
70MP0002722_abnormal_immune_system1.41153831
71MP0000462_abnormal_digestive_system1.38284467
72MP0008469_abnormal_protein_level1.35034800
73MP0000689_abnormal_spleen_morphology1.33998473
74MP0000703_abnormal_thymus_morphology1.33079160
75MP0002138_abnormal_hepatobiliary_system1.31344679
76MP0000490_abnormal_crypts_of1.29736227
77MP0004883_abnormal_blood_vessel1.29217783
78MP0002295_abnormal_pulmonary_circulatio1.28510406
79MP0006054_spinal_hemorrhage1.28319762
80MP0009764_decreased_sensitivity_to1.26486181
81MP0003091_abnormal_cell_migration1.23339981
82MP0003172_abnormal_lysosome_physiology1.22476650
83MP0002166_altered_tumor_susceptibility1.22092536
84MP0000566_synostosis1.21722071
85MP0001348_abnormal_lacrimal_gland1.20465060
86MP0001963_abnormal_hearing_physiology1.16589361
87MP0001873_stomach_inflammation1.16418927
88MP0001663_abnormal_digestive_system1.16418222
89MP0000647_abnormal_sebaceous_gland1.15927351
90MP0009278_abnormal_bone_marrow1.15095857
91MP0003279_aneurysm1.14199615
92MP0005166_decreased_susceptibility_to1.13459372
93MP0005623_abnormal_meninges_morphology1.13147713
94MP0002148_abnormal_hypersensitivity_rea1.12806788
95MP0003724_increased_susceptibility_to1.12170884
96MP0009046_muscle_twitch1.11621918
97MP0005390_skeleton_phenotype1.10817476
98MP0003195_calcinosis1.10181942
99MP0008438_abnormal_cutaneous_collagen1.07474022
100MP0005551_abnormal_eye_electrophysiolog1.06774711
101MP0002132_abnormal_respiratory_system1.06743149
102MP0005023_abnormal_wound_healing1.03516853
103MP0002006_tumorigenesis1.01390669
104MP0009840_abnormal_foam_cell1.01190348
105MP0000955_abnormal_spinal_cord1.00679456
106MP0002277_abnormal_respiratory_mucosa0.98596721
107MP0005195_abnormal_posterior_eye0.98518458
108MP0002734_abnormal_mechanical_nocicepti0.98241032
109MP0000249_abnormal_blood_vessel0.97350789
110MP0005167_abnormal_blood-brain_barrier0.96741510
111MP0003656_abnormal_erythrocyte_physiolo0.95433244
112MP0004147_increased_porphyrin_level0.95126609
113MP0002882_abnormal_neuron_morphology0.93992204
114MP0003566_abnormal_cell_adhesion0.92725133
115MP0002066_abnormal_motor_capabilities/c0.92105489
116MP0000343_altered_response_to0.91690005
117MP0009745_abnormal_behavioral_response0.91129344
118MP0003075_altered_response_to0.90776842
119MP0001970_abnormal_pain_threshold0.90568824
120MP0005408_hypopigmentation0.90468511
121MP0002752_abnormal_somatic_nervous0.88499062
122MP0002933_joint_inflammation0.88358085
123MP0003938_abnormal_ear_development0.88011004
124MP0002419_abnormal_innate_immunity0.87792154
125MP0005387_immune_system_phenotype0.87108009
126MP0001790_abnormal_immune_system0.87108009
127MP0004808_abnormal_hematopoietic_stem0.87077148
128MP0003937_abnormal_limbs/digits/tail_de0.86963320
129MP0000579_abnormal_nail_morphology0.86757191
130MP0000465_gastrointestinal_hemorrhage0.84690916
131MP0003045_fibrosis0.83127247
132MP0008569_lethality_at_weaning0.82730595
133MP0009763_increased_sensitivity_to0.82274554
134MP0000762_abnormal_tongue_morphology0.80639967
135MP0005000_abnormal_immune_tolerance0.80144733
136MP0009250_abnormal_appendicular_skeleto0.79737479
137MP0001545_abnormal_hematopoietic_system0.78736561
138MP0005397_hematopoietic_system_phenotyp0.78736561
139MP0005379_endocrine/exocrine_gland_phen0.78591653
140MP0001299_abnormal_eye_distance/0.78402257
141MP0003705_abnormal_hypodermis_morpholog0.78120250
142MP0000372_irregular_coat_pigmentation0.77995044
143MP0005076_abnormal_cell_differentiation0.77948501
144MP0001835_abnormal_antigen_presentation0.76422972
145MP0002133_abnormal_respiratory_system0.76115553
146MP0005388_respiratory_system_phenotype0.76115553
147MP0002572_abnormal_emotion/affect_behav0.75650364
148MP0005381_digestive/alimentary_phenotyp0.75088479
149MP0005310_abnormal_salivary_gland0.73729200
150MP0003635_abnormal_synaptic_transmissio0.73608595
151MP0004510_myositis0.73145442
152MP0003795_abnormal_bone_structure0.72724323
153MP0001177_atelectasis0.71227799
154MP0002163_abnormal_gland_morphology0.70926163
155MP0002067_abnormal_sensory_capabilities0.70472175
156MP0000015_abnormal_ear_pigmentation0.69096969
157MP0005671_abnormal_response_to0.68094689
158MP0002938_white_spotting0.68032629
159MP0000026_abnormal_inner_ear0.67804314
160MP0001440_abnormal_grooming_behavior0.67733106
161MP0001664_abnormal_digestion0.67695484
162MP0005164_abnormal_response_to0.67657763
163MP0009785_altered_susceptibility_to0.67100155
164MP0002139_abnormal_hepatobiliary_system0.66862978
165MP0000477_abnormal_intestine_morphology0.65738618
166MP0004924_abnormal_behavior0.65078495
167MP0005386_behavior/neurological_phenoty0.65078495
168MP0000747_muscle_weakness0.63065778
169MP0001986_abnormal_taste_sensitivity0.60186329
170MP0002877_abnormal_melanocyte_morpholog0.59943050
171MP0002136_abnormal_kidney_physiology0.57874737
172MP0010368_abnormal_lymphatic_system0.57841210

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.90632965
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.90632965
3Neurofibrillary tangles (HP:0002185)6.67319953
4Eczematoid dermatitis (HP:0000976)5.58580952
5Parakeratosis (HP:0001036)5.43326102
6Myositis (HP:0100614)5.29282707
7Orchitis (HP:0100796)4.91465116
8Abnormality of the corticospinal tract (HP:0002492)4.80848594
9Recurrent bacterial skin infections (HP:0005406)4.63054591
10Recurrent abscess formation (HP:0002722)4.62491013
11Cerebral inclusion bodies (HP:0100314)4.55257160
12Peripheral hypomyelination (HP:0007182)4.50676546
13Optic neuritis (HP:0100653)4.50062791
14Retrobulbar optic neuritis (HP:0100654)4.50062791
15Elevated erythrocyte sedimentation rate (HP:0003565)4.46592041
16Onion bulb formation (HP:0003383)4.15951193
17T lymphocytopenia (HP:0005403)3.99281851
18Segmental peripheral demyelination/remyelination (HP:0003481)3.95244960
19Spontaneous hematomas (HP:0007420)3.85829962
20Abnormality of T cell number (HP:0011839)3.83509022
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.81694572
22Gastrointestinal infarctions (HP:0005244)3.63043547
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.54868664
24Recurrent fungal infections (HP:0002841)3.49952573
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.49402717
26Supranuclear gaze palsy (HP:0000605)3.48808221
27Sensory axonal neuropathy (HP:0003390)3.32794731
28Insidious onset (HP:0003587)3.30159926
29Termporal pattern (HP:0011008)3.30159926
30Encephalitis (HP:0002383)3.28069712
31Mediastinal lymphadenopathy (HP:0100721)3.25554980
32Peritonitis (HP:0002586)3.25318398
33Abnormal auditory evoked potentials (HP:0006958)3.24892689
34Meningitis (HP:0001287)3.19673185
35Recurrent gram-negative bacterial infections (HP:0005420)3.16421019
36Keratoconjunctivitis sicca (HP:0001097)3.13620904
37Retinal dysplasia (HP:0007973)3.11271149
38Recurrent skin infections (HP:0001581)3.10167509
39Cerebral hypomyelination (HP:0006808)3.08453602
40Axonal loss (HP:0003447)3.08451124
41Gingivitis (HP:0000230)3.07389870
42Spastic gait (HP:0002064)3.06632731
43Increased serum pyruvate (HP:0003542)3.05396917
44Abnormality of glycolysis (HP:0004366)3.05396917
45Cerebral hemorrhage (HP:0001342)3.04502070
46Chronic obstructive pulmonary disease (HP:0006510)2.98298710
47Obstructive lung disease (HP:0006536)2.98298710
48Vasculitis (HP:0002633)2.97446398
49Hepatosplenomegaly (HP:0001433)2.97107978
50Pulmonary infiltrates (HP:0002113)2.94760037
51Chest pain (HP:0100749)2.93463847
52Stridor (HP:0010307)2.91178772
53Leukodystrophy (HP:0002415)2.90165168
54Prolonged bleeding time (HP:0003010)2.88839086
55Congenital ichthyosiform erythroderma (HP:0007431)2.87100284
56Chronic mucocutaneous candidiasis (HP:0002728)2.86548447
57Recurrent cutaneous fungal infections (HP:0011370)2.86548447
58Keratoconjunctivitis (HP:0001096)2.86065667
59Alacrima (HP:0000522)2.85058980
60Pustule (HP:0200039)2.84579129
61Hypoplastic pelvis (HP:0008839)2.81329945
62Abnormality of T cells (HP:0002843)2.81113621
63Slow saccadic eye movements (HP:0000514)2.78448221
64Hemoptysis (HP:0002105)2.77591988
65Inflammation of the large intestine (HP:0002037)2.75767888
66Ankle clonus (HP:0011448)2.75211238
67Absent septum pellucidum (HP:0001331)2.72515563
68Leukocytosis (HP:0001974)2.71763817
69Autoamputation (HP:0001218)2.70540546
70Anteriorly placed anus (HP:0001545)2.69670289
71Increased IgE level (HP:0003212)2.64600060
72Recurrent viral infections (HP:0004429)2.64047734
73Dysmetria (HP:0001310)2.63989563
74Abnormality of the phalanges of the 2nd finger (HP:0009541)2.62964175
75Intention tremor (HP:0002080)2.62794513
76Gastrointestinal inflammation (HP:0004386)2.61059699
77Epistaxis (HP:0000421)2.59315477
78Scanning speech (HP:0002168)2.56509305
79Premature skin wrinkling (HP:0100678)2.56240334
80Subacute progressive viral hepatitis (HP:0006572)2.56145686
81Arterial thrombosis (HP:0004420)2.54916665
82Malnutrition (HP:0004395)2.53609296
83Gingival bleeding (HP:0000225)2.52449143
84Loss of speech (HP:0002371)2.51679881
85Increased IgM level (HP:0003496)2.48000731
86Urticaria (HP:0001025)2.47535267
87Cellulitis (HP:0100658)2.47415795
88Pulmonary embolism (HP:0002204)2.45951287
89White forelock (HP:0002211)2.41958769
90Patchy hypopigmentation of hair (HP:0011365)2.41520723
91Autoimmune hemolytic anemia (HP:0001890)2.40145403
92Episodic fever (HP:0001954)2.34885364
93Prolonged neonatal jaundice (HP:0006579)2.34158444
94Abnormality of the peritoneum (HP:0002585)2.31076616
95Abnormality of the septum pellucidum (HP:0007375)2.29865721
96Hypoplasia of the iris (HP:0007676)2.29224908
97Morphological abnormality of the inner ear (HP:0011390)2.27272523
98Metabolic alkalosis (HP:0200114)2.26542274
99Petechiae (HP:0000967)2.25730124
100Partial duplication of thumb phalanx (HP:0009944)2.25665568
101Foot dorsiflexor weakness (HP:0009027)2.25021362
102Recurrent bronchitis (HP:0002837)2.24049290
103Thickened helices (HP:0000391)2.23738874
104Chronic diarrhea (HP:0002028)2.22898489
105Colitis (HP:0002583)2.22894125
106Granulocytopenia (HP:0001913)2.22516452
107Glomerulopathy (HP:0100820)2.22375188
108Spondylolisthesis (HP:0003302)2.21394460
109Absent frontal sinuses (HP:0002688)2.21311573
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21174983
111Clumsiness (HP:0002312)2.21049404
112Pheochromocytoma (HP:0002666)2.20651438
113Viral hepatitis (HP:0006562)2.20042199
114Spastic tetraparesis (HP:0001285)2.19820640
115Abnormality of the nasal mucosa (HP:0000433)2.18460646
116Decreased lacrimation (HP:0000633)2.17595300
117Autoimmune thrombocytopenia (HP:0001973)2.16274015
118Split foot (HP:0001839)2.12820951
119Abnormality of macrophages (HP:0004311)2.11935221
120Myokymia (HP:0002411)2.11906280
121Abnormality of the middle phalanges of the toes (HP:0010183)2.10433719
122Abnormality of the pleura (HP:0002103)2.09712882
123Coronal craniosynostosis (HP:0004440)2.08433897
124CNS hypomyelination (HP:0003429)2.07732227
125Hypergammaglobulinemia (HP:0010702)2.07664171
126Dilatation of the ascending aorta (HP:0005111)2.07649474
127Hematochezia (HP:0002573)2.06458114
128Methylmalonic acidemia (HP:0002912)2.06082689
129Eosinophilia (HP:0001880)2.04529907
130Aplasia involving bones of the upper limbs (HP:0009823)2.03285349
131Aplasia of the phalanges of the hand (HP:0009802)2.03285349
132Aplasia involving bones of the extremities (HP:0009825)2.03285349
133Renal Fanconi syndrome (HP:0001994)2.02371465
134Peripheral demyelination (HP:0011096)2.01886999
135Periodontitis (HP:0000704)2.01742645
136Hemiplegia (HP:0002301)2.01292098
137Hypophosphatemic rickets (HP:0004912)2.00945543
138Anomalous pulmonary venous return (HP:0010772)2.00133585
139Abnormal platelet volume (HP:0011876)2.00072225
140Increased circulating renin level (HP:0000848)1.99863934
141Muscle fiber splitting (HP:0003555)1.99540361
142Cupped ear (HP:0000378)1.99424810
143Panhypogammaglobulinemia (HP:0003139)1.99261470
144Anorexia (HP:0002039)1.99176150
145Abnormality of the foot musculature (HP:0001436)1.99170849
146Decreased motor nerve conduction velocity (HP:0003431)1.99165230
147Stomatitis (HP:0010280)1.98734760
148Lower limb muscle weakness (HP:0007340)1.98589123
149Amyloidosis (HP:0011034)1.98276897
150Duplicated collecting system (HP:0000081)1.98130954
151Nasal polyposis (HP:0100582)1.97895910
152Abnormality of T cell physiology (HP:0011840)1.97768199
153Osteomyelitis (HP:0002754)1.97246801
1543-Methylglutaconic aciduria (HP:0003535)1.96508662
155Hypokalemic alkalosis (HP:0001949)1.93467529
156Partial duplication of the phalanx of hand (HP:0009999)1.92941649
157Increased neuronal autofluorescent lipopigment (HP:0002074)1.90395568
158Neuroendocrine neoplasm (HP:0100634)1.88544567
159Adrenal hypoplasia (HP:0000835)1.88425651
160Hyperactive renin-angiotensin system (HP:0000841)1.87976384
161Urinary incontinence (HP:0000020)1.87283257
162Abolished electroretinogram (ERG) (HP:0000550)1.86838490
163Interstitial pulmonary disease (HP:0006530)1.85087543
164Erythroderma (HP:0001019)1.84058354
165Osteolytic defects of the hand bones (HP:0009699)1.83045866
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.83045866
167Esophageal atresia (HP:0002032)1.82874863
168Abnormality of the pericardium (HP:0001697)1.82251222
169Infantile muscular hypotonia (HP:0008947)1.81673076
170Abnormality of the pulmonary veins (HP:0011718)1.81351379
171Gangrene (HP:0100758)1.80647639
172Abnormality of eosinophils (HP:0001879)1.80570640
173Papilledema (HP:0001085)1.80243871
174Duplication of thumb phalanx (HP:0009942)1.80057351
175Hypomagnesemia (HP:0002917)1.79685664
176Stomach cancer (HP:0012126)1.79119468
177Polygenic inheritance (HP:0010982)1.78563722
178Poor speech (HP:0002465)1.78403361
179Aortic dissection (HP:0002647)1.77863088
180Abnormality of cells of the lymphoid lineage (HP:0012140)1.77720762
181Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77128385
182Progressive neurologic deterioration (HP:0002344)1.76769505
183Lymphopenia (HP:0001888)1.76351050
184Stenosis of the external auditory canal (HP:0000402)1.76267394
185Abnormality of the renal collecting system (HP:0004742)1.75525931
186Chronic otitis media (HP:0000389)1.75353887
187Gowers sign (HP:0003391)1.75283815
188Skin ulcer (HP:0200042)1.74435940
189Agammaglobulinemia (HP:0004432)1.71990498
190Septo-optic dysplasia (HP:0100842)1.71783801
191Abnormality of oral frenula (HP:0000190)1.71336179
192Bowel incontinence (HP:0002607)1.69163367
193Spastic paraparesis (HP:0002313)1.67514017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.28170833
2EPHB14.41983198
3OXSR14.08801914
4MAPKAPK53.74836424
5RIPK43.68958801
6MAP4K13.65183514
7PBK3.45202640
8PKN12.91444612
9ERN12.80016342
10TYK22.75573428
11TXK2.70259517
12FES2.58597483
13BCR2.56312992
14WNK42.41425863
15ZAP702.32949679
16MET2.14805349
17TAOK32.11019741
18JAK32.06831185
19GRK61.97275759
20MAP2K31.95051608
21TESK21.92033674
22FGFR21.90813443
23CLK11.79519316
24WNK11.78556134
25IKBKE1.76984658
26CDK191.70407307
27LIMK11.68610565
28TBK11.64180503
29CSNK1A1L1.59765615
30FGR1.59087182
31BTK1.55831368
32CSNK1G31.55556678
33KIT1.55085242
34MAP3K31.48967879
35JAK11.48930991
36SYK1.47887032
37MST41.45604562
38UHMK11.44215533
39MUSK1.43691125
40TNK21.43639330
41HCK1.40397023
42MAP3K111.37906066
43CAMK2B1.37510160
44BMPR1B1.34880456
45RIPK11.31663590
46ROCK21.29929528
47NEK61.28388442
48NTRK11.27488263
49DYRK21.27430257
50SGK2231.27247558
51SGK4941.27247558
52TGFBR21.25392302
53PNCK1.24246660
54CSNK1G11.19852871
55IRAK11.17772651
56LYN1.16806046
57TESK11.16319552
58CASK1.15763652
59MAP3K11.15026197
60TAOK11.13393413
61PTK61.06657410
62CAMK2D1.06522056
63CSNK1G21.03542321
64BLK1.02923906
65ACVR1B1.00682479
66STK101.00588228
67RPS6KA50.98310808
68TEC0.95789909
69JAK20.94502230
70PRKG20.92769529
71MST1R0.92302884
72PRKCQ0.90359492
73KDR0.88730508
74PIK3CG0.88333137
75GRK10.88003075
76CDC42BPA0.87382693
77CAMK2G0.86008738
78PRKD10.83965912
79LRRK20.82699662
80MATK0.82071205
81MAPK70.81182739
82FGFR30.78797053
83MAP3K140.78397931
84MAPK150.78148229
85YES10.77995850
86MAP2K20.77603848
87TRPM70.76692970
88MARK20.75198658
89PDK10.74579392
90CAMK2A0.74520523
91FGFR40.73751298
92BMPR20.73412569
93IRAK30.72995690
94STK380.71286965
95MKNK10.70718428
96PRKCE0.70280472
97NLK0.68948228
98MAP3K130.68518095
99PDGFRB0.66939837
100TRIB30.66773723
101TTN0.66376059
102GRK70.65880585
103SMG10.64002770
104ADRBK20.62326282
105PIM10.60486035
106PAK60.60322489
107TAOK20.60046516
108ERBB40.59507628
109CSF1R0.56347222
110HIPK20.56217425
111GSK3A0.53937849
112MAP3K70.52969683
113TIE10.51526795
114CDK140.50638307
115DYRK1B0.50156434
116MARK30.49983973
117PAK30.49829855
118LMTK20.49725017
119CDK50.49575539
120PDPK10.47770003
121PRKG10.47503061
122MOS0.45893221
123CSNK1D0.45840084
124IKBKB0.45482888
125IRAK40.44901243
126ARAF0.44256245
127CDK60.43680362
128MAP3K100.43228487
129CDK150.43104516
130MAP4K20.43072703
131CSNK1A10.43042412
132RET0.42711863
133MAP3K20.42294549
134DMPK0.42213931
135FYN0.41914466
136MAPK110.41909595
137LCK0.39472134
138BMX0.38686719
139CAMKK20.38452115
140ITK0.38062029
141MAPKAPK20.37915928
142SIK30.37811653
143CDK180.37557769
144ABL20.37346077
145CDK11A0.36965168
146ICK0.36209802
147TNIK0.35837369
148PAK10.35799154
149IRAK20.35396190
150EPHA30.34953011
151PRKACB0.34743365
152MARK10.34320812
153CAMK1G0.34119422
154PIK3CA0.33987091
155EPHA20.33609163
156NUAK10.32293985
157RPS6KC10.31980631
158RPS6KL10.31980631
159STK240.31955324
160PRPF4B0.31735374
161CSK0.31586699
162PRKD20.31573479
163PHKG20.31389568
164PHKG10.31389568
165PINK10.31352982
166MELK0.31019130
167ABL10.30707501
168PTK2B0.30182664
169KSR20.30084231
170MAPK130.29109266
171DAPK30.26685141

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.86393873
2Steroid biosynthesis_Homo sapiens_hsa001005.17113748
3Fatty acid elongation_Homo sapiens_hsa000624.97102028
4Ether lipid metabolism_Homo sapiens_hsa005653.30010890
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14787789
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.09966770
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70503756
8Leishmaniasis_Homo sapiens_hsa051402.48426443
9Osteoclast differentiation_Homo sapiens_hsa043802.43516918
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.36853547
11Histidine metabolism_Homo sapiens_hsa003402.08051101
12Protein export_Homo sapiens_hsa030602.05162061
13Primary immunodeficiency_Homo sapiens_hsa053402.03515153
14Vitamin B6 metabolism_Homo sapiens_hsa007502.03313642
15Antigen processing and presentation_Homo sapiens_hsa046121.96709033
16Sphingolipid metabolism_Homo sapiens_hsa006001.84394795
17Linoleic acid metabolism_Homo sapiens_hsa005911.83674395
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81321625
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80546518
20T cell receptor signaling pathway_Homo sapiens_hsa046601.72332930
21Tuberculosis_Homo sapiens_hsa051521.71230829
22B cell receptor signaling pathway_Homo sapiens_hsa046621.70933941
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67899883
24Measles_Homo sapiens_hsa051621.64907820
25Sulfur metabolism_Homo sapiens_hsa009201.64355895
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64034374
27Hematopoietic cell lineage_Homo sapiens_hsa046401.61617851
28Type I diabetes mellitus_Homo sapiens_hsa049401.59183365
29Toxoplasmosis_Homo sapiens_hsa051451.55190532
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50113331
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50006382
32Oxidative phosphorylation_Homo sapiens_hsa001901.45849748
33Viral myocarditis_Homo sapiens_hsa054161.44869208
34TNF signaling pathway_Homo sapiens_hsa046681.44205289
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43643131
36Influenza A_Homo sapiens_hsa051641.39171373
37Acute myeloid leukemia_Homo sapiens_hsa052211.31556172
38Platelet activation_Homo sapiens_hsa046111.28573217
39Autoimmune thyroid disease_Homo sapiens_hsa053201.28529844
40Herpes simplex infection_Homo sapiens_hsa051681.28005473
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27984420
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24405203
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.22951150
44Nitrogen metabolism_Homo sapiens_hsa009101.21042989
45Rheumatoid arthritis_Homo sapiens_hsa053231.19201073
46Shigellosis_Homo sapiens_hsa051311.16997598
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14716932
48Axon guidance_Homo sapiens_hsa043601.14291395
49Allograft rejection_Homo sapiens_hsa053301.11955528
50Graft-versus-host disease_Homo sapiens_hsa053321.11112341
51Hepatitis C_Homo sapiens_hsa051601.08737780
52Apoptosis_Homo sapiens_hsa042101.06491443
53Hepatitis B_Homo sapiens_hsa051611.05792639
54Parkinsons disease_Homo sapiens_hsa050121.05751997
55Non-small cell lung cancer_Homo sapiens_hsa052231.05190552
56Arachidonic acid metabolism_Homo sapiens_hsa005901.03599265
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03595478
58Chronic myeloid leukemia_Homo sapiens_hsa052201.03346443
59Pancreatic cancer_Homo sapiens_hsa052121.03093162
60Lysosome_Homo sapiens_hsa041421.02938450
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02737562
62Arginine and proline metabolism_Homo sapiens_hsa003301.00728999
63Legionellosis_Homo sapiens_hsa051341.00330093
64Alzheimers disease_Homo sapiens_hsa050100.99550679
65Serotonergic synapse_Homo sapiens_hsa047260.99540153
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.98474147
67Notch signaling pathway_Homo sapiens_hsa043300.98074010
68Renal cell carcinoma_Homo sapiens_hsa052110.95719102
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94930285
70Malaria_Homo sapiens_hsa051440.90980947
71Other glycan degradation_Homo sapiens_hsa005110.89904868
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86924347
73Amoebiasis_Homo sapiens_hsa051460.85250633
74Phagosome_Homo sapiens_hsa041450.83820571
75Butanoate metabolism_Homo sapiens_hsa006500.83751812
76Ovarian steroidogenesis_Homo sapiens_hsa049130.82317865
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81974009
78VEGF signaling pathway_Homo sapiens_hsa043700.75766861
79Tight junction_Homo sapiens_hsa045300.74990174
80GABAergic synapse_Homo sapiens_hsa047270.73964196
81Glutamatergic synapse_Homo sapiens_hsa047240.72695961
82Collecting duct acid secretion_Homo sapiens_hsa049660.71904493
83Asthma_Homo sapiens_hsa053100.71124298
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70672976
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70388368
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.69666580
87Mineral absorption_Homo sapiens_hsa049780.69206971
88Vibrio cholerae infection_Homo sapiens_hsa051100.67700658
89Prolactin signaling pathway_Homo sapiens_hsa049170.67546072
90Long-term depression_Homo sapiens_hsa047300.67370791
91Ras signaling pathway_Homo sapiens_hsa040140.66937001
92Glutathione metabolism_Homo sapiens_hsa004800.64522484
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64003348
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62427695
95Morphine addiction_Homo sapiens_hsa050320.61617983
96FoxO signaling pathway_Homo sapiens_hsa040680.59809204
97Small cell lung cancer_Homo sapiens_hsa052220.59747581
98Chemokine signaling pathway_Homo sapiens_hsa040620.56618778
99Dorso-ventral axis formation_Homo sapiens_hsa043200.56217812
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56056578
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.55976278
102Vitamin digestion and absorption_Homo sapiens_hsa049770.55810076
103Viral carcinogenesis_Homo sapiens_hsa052030.55340984
104HTLV-I infection_Homo sapiens_hsa051660.55115135
105Endocytosis_Homo sapiens_hsa041440.54751113
106Choline metabolism in cancer_Homo sapiens_hsa052310.53715193
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53403606
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53205194
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53012676
110Folate biosynthesis_Homo sapiens_hsa007900.52529593
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.52397097
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52161593
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.52080269
114Cocaine addiction_Homo sapiens_hsa050300.51802097
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.51185854
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50771464
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.50515010
118Focal adhesion_Homo sapiens_hsa045100.49904717
119Endometrial cancer_Homo sapiens_hsa052130.49004589
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.48841980
121Rap1 signaling pathway_Homo sapiens_hsa040150.48725104
122African trypanosomiasis_Homo sapiens_hsa051430.48686701
123Epstein-Barr virus infection_Homo sapiens_hsa051690.47758458
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46548574
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.45776558
126Pertussis_Homo sapiens_hsa051330.45642083
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43285239
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42553838
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42430303
130Insulin resistance_Homo sapiens_hsa049310.42391090
131Salmonella infection_Homo sapiens_hsa051320.41706159
132GnRH signaling pathway_Homo sapiens_hsa049120.41522088
133Inositol phosphate metabolism_Homo sapiens_hsa005620.41285233
134Peroxisome_Homo sapiens_hsa041460.40547684
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40328167
136Colorectal cancer_Homo sapiens_hsa052100.39846633
137Proteoglycans in cancer_Homo sapiens_hsa052050.39824942
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39770054
139Renin-angiotensin system_Homo sapiens_hsa046140.39751619
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39734568
141Prion diseases_Homo sapiens_hsa050200.39342585
142HIF-1 signaling pathway_Homo sapiens_hsa040660.38512901
143Phototransduction_Homo sapiens_hsa047440.38434138
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38339900
145Fatty acid metabolism_Homo sapiens_hsa012120.37746245
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.35975751
147Thyroid cancer_Homo sapiens_hsa052160.35271992
148Pathways in cancer_Homo sapiens_hsa052000.34583967
149Regulation of autophagy_Homo sapiens_hsa041400.34449194
150MAPK signaling pathway_Homo sapiens_hsa040100.34090146
151ECM-receptor interaction_Homo sapiens_hsa045120.33300525
152Huntingtons disease_Homo sapiens_hsa050160.33162117
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31482656
154Retinol metabolism_Homo sapiens_hsa008300.30448217
155NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30315025
156Metabolic pathways_Homo sapiens_hsa011000.28909793
157NF-kappa B signaling pathway_Homo sapiens_hsa040640.28747711
158Staphylococcus aureus infection_Homo sapiens_hsa051500.28414327
159Hedgehog signaling pathway_Homo sapiens_hsa043400.28400647
160Chemical carcinogenesis_Homo sapiens_hsa052040.27162497
161Salivary secretion_Homo sapiens_hsa049700.23950584
162Circadian entrainment_Homo sapiens_hsa047130.23845925
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23529983
164Gastric acid secretion_Homo sapiens_hsa049710.20751577
165Propanoate metabolism_Homo sapiens_hsa006400.20412234
166PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20314566
167Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19157696
168Cholinergic synapse_Homo sapiens_hsa047250.18713379

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »