PRRC2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.39360360
2locomotory exploration behavior (GO:0035641)5.20312679
3layer formation in cerebral cortex (GO:0021819)5.15427368
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04735868
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02034008
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.34182327
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.28573838
8vocalization behavior (GO:0071625)4.24560474
9dendritic spine morphogenesis (GO:0060997)4.13093623
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06791775
11regulation of synapse structural plasticity (GO:0051823)3.97633452
12synaptic vesicle exocytosis (GO:0016079)3.97613248
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.93958575
14glutamate secretion (GO:0014047)3.92516089
15exploration behavior (GO:0035640)3.87044558
16regulation of synaptic vesicle exocytosis (GO:2000300)3.85072933
17regulation of glutamate receptor signaling pathway (GO:1900449)3.83990467
18positive regulation of synapse maturation (GO:0090129)3.71909662
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.71858175
20sodium ion export (GO:0071436)3.68782689
21dendrite morphogenesis (GO:0048813)3.67937134
22activation of protein kinase A activity (GO:0034199)3.67614432
23cell migration in hindbrain (GO:0021535)3.59069555
24protein localization to synapse (GO:0035418)3.52905244
25establishment of nucleus localization (GO:0040023)3.50378178
26regulation of neuronal synaptic plasticity (GO:0048168)3.44331754
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.42990328
28cell communication by electrical coupling (GO:0010644)3.41862111
29axonal fasciculation (GO:0007413)3.39723715
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39363817
31neurotransmitter secretion (GO:0007269)3.37415031
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35686634
33glucocorticoid receptor signaling pathway (GO:0042921)3.35339290
34proline transport (GO:0015824)3.31939804
35neuromuscular process controlling balance (GO:0050885)3.29257819
36regulation of synaptic vesicle transport (GO:1902803)3.24910891
37cerebellar granule cell differentiation (GO:0021707)3.23896993
38adherens junction assembly (GO:0034333)3.23208100
39neuron cell-cell adhesion (GO:0007158)3.21063995
40regulation of ARF protein signal transduction (GO:0032012)3.20389506
41cerebellar Purkinje cell layer development (GO:0021680)3.19969303
42semaphorin-plexin signaling pathway (GO:0071526)3.19247038
43neuron recognition (GO:0008038)3.18410824
44cellular potassium ion homeostasis (GO:0030007)3.17646459
45central nervous system projection neuron axonogenesis (GO:0021952)3.15997820
46cerebellar Purkinje cell differentiation (GO:0021702)3.08503587
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.06672629
48auditory behavior (GO:0031223)3.04343338
49camera-type eye morphogenesis (GO:0048593)2.98504259
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97055378
51regulation of dendritic spine morphogenesis (GO:0061001)2.96085768
52apical protein localization (GO:0045176)2.94231886
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.93997654
54vesicle transport along microtubule (GO:0047496)2.93483654
55cell-substrate adherens junction assembly (GO:0007045)2.93314617
56focal adhesion assembly (GO:0048041)2.93314617
57regulation of NFAT protein import into nucleus (GO:0051532)2.87288329
58neurotransmitter-gated ion channel clustering (GO:0072578)2.85399883
59clathrin coat assembly (GO:0048268)2.85235288
60dendritic spine organization (GO:0097061)2.84010057
61innervation (GO:0060384)2.83699334
62synaptic vesicle endocytosis (GO:0048488)2.83580947
63gamma-aminobutyric acid transport (GO:0015812)2.83343798
64long-term memory (GO:0007616)2.82515815
65protein-DNA complex disassembly (GO:0032986)2.80759392
66nucleosome disassembly (GO:0006337)2.80759392
67convergent extension (GO:0060026)2.80243540
68positive regulation of dendritic spine morphogenesis (GO:0061003)2.79413326
69organelle transport along microtubule (GO:0072384)2.77862267
70cell-cell junction maintenance (GO:0045217)2.76121236
71synaptic transmission, glutamatergic (GO:0035249)2.75482060
72insulin-like growth factor receptor signaling pathway (GO:0048009)2.75051866
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74558506
74axon extension (GO:0048675)2.73044508
75neural tube development (GO:0021915)2.72549798
76intracellular estrogen receptor signaling pathway (GO:0030520)2.71895236
77prepulse inhibition (GO:0060134)2.70251836
78cell communication involved in cardiac conduction (GO:0086065)2.70220034
79plasma membrane repair (GO:0001778)2.70217039
80regulation of clathrin-mediated endocytosis (GO:2000369)2.69566440
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69532405
82dopamine receptor signaling pathway (GO:0007212)2.69082936
83embryonic camera-type eye morphogenesis (GO:0048596)2.67375300
84Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67119240
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.66676726
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65733976
87positive regulation of membrane potential (GO:0045838)2.64503735
88glutamate receptor signaling pathway (GO:0007215)2.63622219
89pyrimidine nucleobase catabolic process (GO:0006208)2.63179863
90regulation of synaptic plasticity (GO:0048167)2.62268273
91eye morphogenesis (GO:0048592)2.61016943
92glial cell proliferation (GO:0014009)2.61010372
93nerve growth factor signaling pathway (GO:0038180)2.60432885
94corticosteroid receptor signaling pathway (GO:0031958)2.59388491
95neuronal ion channel clustering (GO:0045161)2.59329875
96regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59274051
97regulation of establishment of planar polarity (GO:0090175)2.59181576
98negative regulation of microtubule polymerization (GO:0031115)2.59074167
99response to auditory stimulus (GO:0010996)2.58363289
100positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58246015
101cerebellum development (GO:0021549)2.57332272
102pre-miRNA processing (GO:0031054)2.57084699
103response to pheromone (GO:0019236)2.56658223
104positive regulation of axon extension (GO:0045773)2.56276559
105regulation of synapse maturation (GO:0090128)2.54637980
106negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53950390
107myelination in peripheral nervous system (GO:0022011)2.52349080
108peripheral nervous system axon ensheathment (GO:0032292)2.52349080
109membrane depolarization during action potential (GO:0086010)2.52207172
110membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.51618901
111synapse organization (GO:0050808)2.51102015
112regulation of postsynaptic membrane potential (GO:0060078)2.50940854
113histone H3-K36 demethylation (GO:0070544)2.50394180
114axon cargo transport (GO:0008088)2.49808665
115stress granule assembly (GO:0034063)2.49510637
116establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49419624
117mitochondrion transport along microtubule (GO:0047497)2.49419624
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49240389
119regulation of RNA export from nucleus (GO:0046831)2.49103093
120regulation of nucleobase-containing compound transport (GO:0032239)2.48399394
121regulation of histone H3-K27 methylation (GO:0061085)2.47915328
122paraxial mesoderm development (GO:0048339)2.47348767
123histone H3-K9 demethylation (GO:0033169)2.47226700
124neuron-neuron synaptic transmission (GO:0007270)2.47105509
125regulation of ARF GTPase activity (GO:0032312)2.45706812
126neuron projection extension (GO:1990138)2.45635138
127neurotransmitter transport (GO:0006836)2.45577095
128synapse assembly (GO:0007416)2.45425307
129postsynaptic membrane organization (GO:0001941)2.45356541
130regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45000850
131negative regulation of histone methylation (GO:0031061)2.44964041
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.44748782
133embryonic eye morphogenesis (GO:0048048)2.44683556
134negative regulation of catenin import into nucleus (GO:0035414)2.44660084
135positive regulation of gene expression, epigenetic (GO:0045815)2.42870864
136positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.41104016
137regulation of glucose import in response to insulin stimulus (GO:2001273)2.40831279
138negative regulation of cell size (GO:0045792)2.40755112
139amino acid import (GO:0043090)2.39698635
140establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38645081
141histone lysine demethylation (GO:0070076)2.37949727
142asymmetric protein localization (GO:0008105)2.36523963
143peptidyl-tyrosine autophosphorylation (GO:0038083)2.35444265
144mating behavior (GO:0007617)2.35215591
145activation of Rac GTPase activity (GO:0032863)2.34855577
146regulation of axon extension involved in axon guidance (GO:0048841)2.34661336
147cell-substrate junction assembly (GO:0007044)2.31808837
148apoptotic process involved in morphogenesis (GO:0060561)2.30264936
149maternal placenta development (GO:0001893)2.29260013
150cellular response to epidermal growth factor stimulus (GO:0071364)2.28888729
151peptidyl-threonine phosphorylation (GO:0018107)2.26278338
152forebrain development (GO:0030900)2.25416232
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25162326
154cellular response to catecholamine stimulus (GO:0071870)2.24769108
155cellular response to monoamine stimulus (GO:0071868)2.24769108
156establishment or maintenance of apical/basal cell polarity (GO:0035088)2.24761279
157establishment or maintenance of bipolar cell polarity (GO:0061245)2.24761279
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.22938766
159heart morphogenesis (GO:0003007)2.22753304
160regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.22162266
161response to epidermal growth factor (GO:0070849)2.21711324
162histone demethylation (GO:0016577)2.21256220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.78813738
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.02499118
3DROSHA_22980978_ChIP-Seq_HELA_Human2.69629598
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.63299884
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35249401
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34732240
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34732240
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34493903
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30722391
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29729033
11ZFP281_18757296_ChIP-ChIP_E14_Mouse2.27642699
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26966931
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.16806689
14REST_21632747_ChIP-Seq_MESCs_Mouse2.15970210
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11938412
16KDM2B_26808549_Chip-Seq_K562_Human2.08356298
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07523484
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.05182790
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03550741
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.02732135
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00315912
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97989907
23ZFP281_27345836_Chip-Seq_ESCs_Mouse1.96381848
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.93920828
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93800711
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87899588
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87886847
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87675118
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86787945
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86492151
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.84535773
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83576204
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.82598977
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82485533
35RACK7_27058665_Chip-Seq_MCF-7_Human1.79335625
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78955649
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75466579
38GBX2_23144817_ChIP-Seq_PC3_Human1.70625037
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70177804
40KDM2B_26808549_Chip-Seq_DND41_Human1.70015741
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.69293078
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66558889
43VDR_21846776_ChIP-Seq_THP-1_Human1.62551214
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62280135
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58915710
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.57718933
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.57239764
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55284355
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.53590209
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53457768
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52115960
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51488511
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50328260
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.45018811
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.44765257
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41704741
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38549529
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.36872985
59AR_21572438_ChIP-Seq_LNCaP_Human1.36589259
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32883519
61CLOCK_20551151_ChIP-Seq_293T_Human1.31986891
62AR_19668381_ChIP-Seq_PC3_Human1.31897516
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31888117
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31453249
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.30333809
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29734556
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.29150756
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27578697
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27085464
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26534190
71* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26520330
72LXR_22292898_ChIP-Seq_THP-1_Human1.22891401
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22107791
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20797606
75ZNF274_21170338_ChIP-Seq_K562_Hela1.20595165
76AHR_22903824_ChIP-Seq_MCF-7_Human1.18279618
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17769730
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.17487734
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16946553
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16441539
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15798340
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15183597
83* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14377337
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13585101
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.12785513
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11204425
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11020980
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10347193
89CREB1_26743006_Chip-Seq_LNCaP_Human1.10223971
90TCF7_22412390_ChIP-Seq_EML_Mouse1.10041749
91ZNF263_19887448_ChIP-Seq_K562_Human1.09012539
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.08293908
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07136603
94P68_20966046_ChIP-Seq_HELA_Human1.06224121
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05475710
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03609471
97MYC_22102868_ChIP-Seq_BL_Human1.03479113
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02415452
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.02246676
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00683258
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.00292355
102CTCF_27219007_Chip-Seq_Bcells_Human0.99012561
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99010636
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98861264
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98120959
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.97855765
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96012813
108* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95911265
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95863747
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95206004
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95122461
112SMAD4_21799915_ChIP-Seq_A2780_Human0.94883615
113TP53_22127205_ChIP-Seq_IMR90_Human0.94530539
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.94525948
115E2F7_22180533_ChIP-Seq_HELA_Human0.94380590
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.94150520
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.91144625
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89361127
119SMC4_20622854_ChIP-Seq_HELA_Human0.88993965
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88180554
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87910485
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.86742983
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86213552
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.85803379
125STAT3_23295773_ChIP-Seq_U87_Human0.84257860
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83780762
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82546821
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.82277205
129PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81858142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01575000
2MP0003635_abnormal_synaptic_transmissio3.44770067
3MP0004270_analgesia3.36897359
4MP0009780_abnormal_chondrocyte_physiolo2.79247095
5MP0000566_synostosis2.77881808
6MP0002063_abnormal_learning/memory/cond2.72980229
7MP0005409_darkened_coat_color2.60723697
8MP0005423_abnormal_somatic_nervous2.48638597
9MP0003283_abnormal_digestive_organ2.38875463
10MP0003880_abnormal_central_pattern2.35128964
11MP0002909_abnormal_adrenal_gland2.32341716
12MP0002249_abnormal_larynx_morphology2.29299523
13MP0009745_abnormal_behavioral_response2.26264407
14MP0000569_abnormal_digit_pigmentation2.26196146
15MP0004858_abnormal_nervous_system2.22611632
16MP0000778_abnormal_nervous_system2.11961477
17MP0002064_seizures2.08869327
18MP0002009_preneoplasia1.97535102
19MP0002734_abnormal_mechanical_nocicepti1.96052839
20MP0009046_muscle_twitch1.94294370
21MP0002572_abnormal_emotion/affect_behav1.94131463
22MP0004811_abnormal_neuron_physiology1.93378917
23MP0002184_abnormal_innervation1.88263606
24MP0008961_abnormal_basal_metabolism1.85891504
25MP0003122_maternal_imprinting1.76975595
26MP0001486_abnormal_startle_reflex1.73108198
27MP0004885_abnormal_endolymph1.72113003
28MP0003787_abnormal_imprinting1.71174808
29MP0002822_catalepsy1.70915098
30MP0000955_abnormal_spinal_cord1.66930380
31MP0000579_abnormal_nail_morphology1.66885681
32MP0001346_abnormal_lacrimal_gland1.66815077
33MP0008569_lethality_at_weaning1.66486694
34MP0010030_abnormal_orbit_morphology1.66046746
35MP0005187_abnormal_penis_morphology1.61232708
36MP0010234_abnormal_vibrissa_follicle1.61039500
37MP0005623_abnormal_meninges_morphology1.52629641
38MP0009672_abnormal_birth_weight1.52521507
39MP0001968_abnormal_touch/_nociception1.52027650
40MP0000537_abnormal_urethra_morphology1.51094297
41MP0002733_abnormal_thermal_nociception1.49032433
42MP0004233_abnormal_muscle_weight1.48985584
43MP0002557_abnormal_social/conspecific_i1.48276801
44MP0000751_myopathy1.45171253
45MP0002272_abnormal_nervous_system1.44929213
46MP0003705_abnormal_hypodermis_morpholog1.44538068
47MP0005076_abnormal_cell_differentiation1.44228131
48MP0005499_abnormal_olfactory_system1.42447428
49MP0005394_taste/olfaction_phenotype1.42447428
50MP0001984_abnormal_olfaction1.41319220
51MP0002882_abnormal_neuron_morphology1.39881500
52MP0003329_amyloid_beta_deposits1.37508484
53MP0002234_abnormal_pharynx_morphology1.37448619
54MP0002152_abnormal_brain_morphology1.32823862
55MP0001970_abnormal_pain_threshold1.28187079
56MP0005386_behavior/neurological_phenoty1.26636208
57MP0004924_abnormal_behavior1.26636208
58MP0001440_abnormal_grooming_behavior1.26319143
59MP0002697_abnormal_eye_size1.25428414
60MP0002067_abnormal_sensory_capabilities1.23650619
61MP0004185_abnormal_adipocyte_glucose1.22886460
62MP0003091_abnormal_cell_migration1.22768299
63MP0003119_abnormal_digestive_system1.21404063
64MP0002653_abnormal_ependyma_morphology1.20416788
65MP0004145_abnormal_muscle_electrophysio1.19659945
66MP0002116_abnormal_craniofacial_bone1.17971434
67MP0003566_abnormal_cell_adhesion1.17738759
68MP0003861_abnormal_nervous_system1.16503554
69MP0001299_abnormal_eye_distance/1.14630508
70MP0009053_abnormal_anal_canal1.14620387
71MP0005257_abnormal_intraocular_pressure1.14199955
72MP0009278_abnormal_bone_marrow1.12283123
73MP0003938_abnormal_ear_development1.10881020
74MP0003879_abnormal_hair_cell1.10729217
75MP0002735_abnormal_chemical_nociception1.10722297
76MP0002066_abnormal_motor_capabilities/c1.10072942
77MP0000534_abnormal_ureter_morphology1.09138820
78MP0001501_abnormal_sleep_pattern1.08723705
79MP0005645_abnormal_hypothalamus_physiol1.06495721
80MP0000462_abnormal_digestive_system1.06199247
81MP0000013_abnormal_adipose_tissue1.03678908
82MP0000003_abnormal_adipose_tissue1.00732530
83MP0001849_ear_inflammation0.99403826
84MP0010630_abnormal_cardiac_muscle0.98221414
85MP0003121_genomic_imprinting0.98219835
86MP0001348_abnormal_lacrimal_gland0.97864920
87MP0009703_decreased_birth_body0.97573785
88MP0000432_abnormal_head_morphology0.96953593
89MP0002932_abnormal_joint_morphology0.96367877
90MP0002108_abnormal_muscle_morphology0.95611952
91MP0003633_abnormal_nervous_system0.95576931
92MP0002092_abnormal_eye_morphology0.95573695
93MP0001730_embryonic_growth_arrest0.95293741
94MP0008438_abnormal_cutaneous_collagen0.94380256
95MP0002085_abnormal_embryonic_tissue0.94343801
96MP0008789_abnormal_olfactory_epithelium0.93634014
97MP0000631_abnormal_neuroendocrine_gland0.92717215
98MP0004197_abnormal_fetal_growth/weight/0.92330531
99MP0002114_abnormal_axial_skeleton0.92188386
100MP0004264_abnormal_extraembryonic_tissu0.91992639
101MP0002084_abnormal_developmental_patter0.91290816
102MP0003123_paternal_imprinting0.91007068
103MP0004085_abnormal_heartbeat0.90911659
104MP0004272_abnormal_basement_membrane0.90002691
105MP0002089_abnormal_postnatal_growth/wei0.89839284
106MP0003315_abnormal_perineum_morphology0.87120518
107MP0004130_abnormal_muscle_cell0.85783016
108MP0003137_abnormal_impulse_conducting0.85704735
109MP0000678_abnormal_parathyroid_gland0.85051771
110MP0002877_abnormal_melanocyte_morpholog0.84804092
111MP0003984_embryonic_growth_retardation0.83781462
112MP0005248_abnormal_Harderian_gland0.83134317
113MP0005666_abnormal_adipose_tissue0.82132569
114MP0001672_abnormal_embryogenesis/_devel0.81756671
115MP0005380_embryogenesis_phenotype0.81756671
116MP0000762_abnormal_tongue_morphology0.80535872
117MP0003634_abnormal_glial_cell0.80307915
118MP0002088_abnormal_embryonic_growth/wei0.79646047
119MP0003045_fibrosis0.79151150
120MP0002925_abnormal_cardiovascular_devel0.79052611
121MP0001502_abnormal_circadian_rhythm0.78870381
122MP0005503_abnormal_tendon_morphology0.78779987
123MP0002081_perinatal_lethality0.78713988
124MP0002069_abnormal_eating/drinking_beha0.78292982
125MP0003385_abnormal_body_wall0.78060312
126MP0003631_nervous_system_phenotype0.76920351
127MP0005375_adipose_tissue_phenotype0.76879597
128MP0002082_postnatal_lethality0.76647770
129MP0010770_preweaning_lethality0.76647770
130MP0003755_abnormal_palate_morphology0.75900704
131MP0003115_abnormal_respiratory_system0.75806266
132MP0000428_abnormal_craniofacial_morphol0.74389525
133MP0002896_abnormal_bone_mineralization0.74383790
134MP0004087_abnormal_muscle_fiber0.74086254
135MP0005646_abnormal_pituitary_gland0.73846916
136MP0003453_abnormal_keratinocyte_physiol0.73116292
137MP0001177_atelectasis0.72739255
138MP0000733_abnormal_muscle_development0.72491894
139MP0002736_abnormal_nociception_after0.71330005
140MP0003935_abnormal_craniofacial_develop0.71148584
141MP0004215_abnormal_myocardial_fiber0.69581860
142MP0003942_abnormal_urinary_system0.69308653
143MP0010769_abnormal_survival0.67608608
144MP0000747_muscle_weakness0.67535909
145MP0001943_abnormal_respiration0.67287762
146MP0010352_gastrointestinal_tract_polyps0.67172754
147MP0008770_decreased_survivor_rate0.67061161

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.82041753
2Visual hallucinations (HP:0002367)3.55153123
3Focal seizures (HP:0007359)3.45224302
4Focal motor seizures (HP:0011153)3.14928427
5Hyperacusis (HP:0010780)3.14893078
6Insomnia (HP:0100785)2.96359981
7Broad face (HP:0000283)2.90384996
8Abnormality of the lower motor neuron (HP:0002366)2.90128106
9Papilledema (HP:0001085)2.88157506
10Macroorchidism (HP:0000053)2.84224853
11Action tremor (HP:0002345)2.82634450
12Supranuclear gaze palsy (HP:0000605)2.75970364
13Ankle clonus (HP:0011448)2.73946812
14Genetic anticipation (HP:0003743)2.70123221
15Pointed chin (HP:0000307)2.69791689
16Abnormality of the fingertips (HP:0001211)2.68833758
17Turricephaly (HP:0000262)2.66140315
18Elfin facies (HP:0004428)2.64598485
19Abnormality of the distal phalanx of the thumb (HP:0009617)2.59866313
20Neoplasm of the heart (HP:0100544)2.53200717
21Depression (HP:0000716)2.47447012
22Ulnar bowing (HP:0003031)2.47405058
23Urinary bladder sphincter dysfunction (HP:0002839)2.39122054
24Progressive cerebellar ataxia (HP:0002073)2.38848922
25Renal duplication (HP:0000075)2.38335291
26Shallow orbits (HP:0000586)2.37374304
27Epileptic encephalopathy (HP:0200134)2.36990222
28Abnormality of the astrocytes (HP:0100707)2.35184515
29Astrocytoma (HP:0009592)2.35184515
30Poor eye contact (HP:0000817)2.31594342
31Amyotrophic lateral sclerosis (HP:0007354)2.31168811
32Impaired social interactions (HP:0000735)2.30057417
33Abnormal social behavior (HP:0012433)2.30057417
34Renovascular hypertension (HP:0100817)2.28038954
35Dysmetric saccades (HP:0000641)2.27028370
36Ankyloglossia (HP:0010296)2.26225876
37Mutism (HP:0002300)2.26160980
38Overriding aorta (HP:0002623)2.25137468
39Abnormality of the aortic arch (HP:0012303)2.23508411
40Termporal pattern (HP:0011008)2.22635253
41Insidious onset (HP:0003587)2.22635253
42Impaired vibration sensation in the lower limbs (HP:0002166)2.20106690
43High anterior hairline (HP:0009890)2.19584619
44Absence seizures (HP:0002121)2.18375549
45Short 4th metacarpal (HP:0010044)2.17903702
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17903702
47Urinary urgency (HP:0000012)2.17755858
48Long eyelashes (HP:0000527)2.17112740
49Megalencephaly (HP:0001355)2.16429390
50Hemiplegia (HP:0002301)2.13865361
51Impaired smooth pursuit (HP:0007772)2.12728046
52Aplasia involving bones of the upper limbs (HP:0009823)2.11530303
53Aplasia of the phalanges of the hand (HP:0009802)2.11530303
54Aplasia involving bones of the extremities (HP:0009825)2.11530303
55Germ cell neoplasia (HP:0100728)2.11421852
56Drooling (HP:0002307)2.10084261
57Excessive salivation (HP:0003781)2.10084261
58Precocious puberty (HP:0000826)2.09427927
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07793842
60Broad-based gait (HP:0002136)2.07535694
61Protrusio acetabuli (HP:0003179)2.06921014
62Disproportionate tall stature (HP:0001519)2.04953903
63Urethral obstruction (HP:0000796)2.02753402
64Agitation (HP:0000713)2.02152133
65Arnold-Chiari malformation (HP:0002308)2.01498053
66Cerebral aneurysm (HP:0004944)2.01238066
67Sacral dimple (HP:0000960)1.99755833
68Broad metatarsal (HP:0001783)1.99673123
69Obsessive-compulsive behavior (HP:0000722)1.99639814
70Obstructive sleep apnea (HP:0002870)1.99590447
71Bowel diverticulosis (HP:0005222)1.98968011
72Lower limb amyotrophy (HP:0007210)1.98471166
73Ventricular fibrillation (HP:0001663)1.98135597
74Long palpebral fissure (HP:0000637)1.97799229
75Annular pancreas (HP:0001734)1.97591712
76Truncal ataxia (HP:0002078)1.97507015
77Apathy (HP:0000741)1.97441211
78Dislocated radial head (HP:0003083)1.96166067
79Aqueductal stenosis (HP:0002410)1.95966508
80Broad thumb (HP:0011304)1.95434320
81Cerebral inclusion bodies (HP:0100314)1.95119103
82Hepatoblastoma (HP:0002884)1.94357142
83Abnormality of the radial head (HP:0003995)1.93373385
84Hemiparesis (HP:0001269)1.93005076
85Postural instability (HP:0002172)1.92873429
86Dysdiadochokinesis (HP:0002075)1.92832440
87Enlarged penis (HP:0000040)1.92784304
88Generalized tonic-clonic seizures (HP:0002069)1.92250697
89Flat acetabular roof (HP:0003180)1.91337724
90Abnormality of the phalanges of the hallux (HP:0010057)1.90564948
91Upper limb amyotrophy (HP:0009129)1.89996286
92Distal upper limb amyotrophy (HP:0007149)1.89996286
93Atonic seizures (HP:0010819)1.89925699
94Flat cornea (HP:0007720)1.89638545
95Patellar dislocation (HP:0002999)1.87495886
96Increased nuchal translucency (HP:0010880)1.87475267
97Stereotypic behavior (HP:0000733)1.86447498
98Mitral valve prolapse (HP:0001634)1.86353394
99Heterotopia (HP:0002282)1.85220109
100Torticollis (HP:0000473)1.85143261
101Dialeptic seizures (HP:0011146)1.85124666
102Inappropriate behavior (HP:0000719)1.85019092
103Febrile seizures (HP:0002373)1.84767854
104Broad palm (HP:0001169)1.84681710
105Thin ribs (HP:0000883)1.84600313
106Asymmetry of the thorax (HP:0001555)1.83971368
107Abnormality of ocular smooth pursuit (HP:0000617)1.83037081
108Narrow palate (HP:0000189)1.82294779
109Tracheomalacia (HP:0002779)1.82082729
110Advanced eruption of teeth (HP:0006288)1.82051317
111Abnormality of oral frenula (HP:0000190)1.81830050
112Bundle branch block (HP:0011710)1.80633915
113Lymphangioma (HP:0100764)1.79338794
114Bladder diverticulum (HP:0000015)1.79297810
115Difficulty running (HP:0009046)1.77590564
116Intellectual disability, profound (HP:0002187)1.77256902
117Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76459132
118Subacute progressive viral hepatitis (HP:0006572)1.75597896
119Spina bifida occulta (HP:0003298)1.75084532
120EEG with generalized epileptiform discharges (HP:0011198)1.74847312
121Neonatal short-limb short stature (HP:0008921)1.73755023
122Hypsarrhythmia (HP:0002521)1.73493810
123Abnormality of the corticospinal tract (HP:0002492)1.73457518
124Overgrowth (HP:0001548)1.73140003
125Amblyopia (HP:0000646)1.72673320
126Abnormality of the calcaneus (HP:0008364)1.72590649
127Spastic gait (HP:0002064)1.72516487
128Diminished motivation (HP:0000745)1.72232554
129Ependymoma (HP:0002888)1.72147584
130Broad phalanges of the hand (HP:0009768)1.71765937
131Abnormality of the 4th metacarpal (HP:0010012)1.71663850
132Hand muscle atrophy (HP:0009130)1.71135186
133Bronchomalacia (HP:0002780)1.70939516
134Mitral regurgitation (HP:0001653)1.69779598
135Epileptiform EEG discharges (HP:0011182)1.69562005
136Broad finger (HP:0001500)1.69359282
137Hammertoe (HP:0001765)1.68737207
138Deep palmar crease (HP:0006191)1.68449973
139Wide anterior fontanel (HP:0000260)1.67341510
140Hypoventilation (HP:0002791)1.67126465
141Neurofibrillary tangles (HP:0002185)1.67122193
142Buphthalmos (HP:0000557)1.67116563
143Abnormality of the diencephalon (HP:0010662)1.66512114
144Lower limb muscle weakness (HP:0007340)1.66242444
145Vertebral arch anomaly (HP:0008438)1.66122572
146Laryngomalacia (HP:0001601)1.66121396
147Trigonocephaly (HP:0000243)1.65451420
148Persistence of primary teeth (HP:0006335)1.57697005
149Partial duplication of thumb phalanx (HP:0009944)1.56757916
150Cutaneous syndactyly (HP:0012725)1.56633137
151Abnormality of the humeroradial joint (HP:0100744)1.55747528
152Cutaneous finger syndactyly (HP:0010554)1.55323107
153Broad distal phalanx of finger (HP:0009836)1.55006329
154Bowel incontinence (HP:0002607)1.54881574
155Shawl scrotum (HP:0000049)1.53766876
156Arterial tortuosity (HP:0005116)1.53333494
157Megalocornea (HP:0000485)1.53205750
158Genu recurvatum (HP:0002816)1.52643685
159Supernumerary ribs (HP:0005815)1.51625150
160Lower limb asymmetry (HP:0100559)1.51011401
161Sparse lateral eyebrow (HP:0005338)1.50977155
162Broad phalanx (HP:0006009)1.50786890
163Broad long bones (HP:0005622)1.49977341
164Sleep apnea (HP:0010535)1.49022714
165Abnormality of the parietal bone (HP:0002696)1.48691123
166Midface retrusion (HP:0011800)1.48489709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.33828675
2MAP3K93.50400670
3SMG12.93235479
4NTRK32.90179270
5TRIB32.40702221
6PRKD32.37607276
7PAK62.28641331
8MAP3K42.24149355
9EPHA42.19431991
10MINK12.18566192
11NTRK22.07827038
12CAMKK11.99033285
13DAPK21.98547256
14RIPK11.94823784
15SIK21.91532846
16PKN21.87187815
17KSR21.86020840
18FGFR41.84412126
19TYRO31.74723444
20PHKG21.72895369
21PHKG11.72895369
22KSR11.69965554
23LATS21.62077146
24EEF2K1.61885229
25NTRK11.60436428
26PDGFRA1.52942195
27ALK1.50236183
28TAOK11.50046541
29ICK1.44375267
30MAP3K101.35221115
31STK381.32610541
32CAMK1G1.32141118
33MAP3K21.26768728
34RET1.26397705
35CDK51.26050952
36SCYL21.25008381
37MARK21.21188866
38UHMK11.15109281
39MAP2K41.14725402
40CDK121.14635087
41PRKCH1.14022021
42ERBB31.11353554
43PAK31.07317182
44MAPK130.98801646
45STK110.98781181
46CDC42BPA0.92334593
47DDR20.92170834
48NEK10.92002298
49MAP2K70.91327424
50DAPK10.90865557
51PNCK0.89875779
52DMPK0.88514538
53MAP3K70.87827166
54FGFR20.87632112
55LMTK20.86960874
56EPHB20.85816722
57SGK20.85295822
58CSNK1G20.79707947
59PTK60.77111733
60CASK0.76923663
61CDK150.75276309
62RPS6KA20.74942455
63CDK180.73165505
64MTOR0.72366882
65CDK140.71143511
66SGK30.70768484
67MAP3K130.70597251
68AKT30.68968732
69CAMK1D0.66023023
70CDK11A0.64882622
71FER0.64714203
72PRKCG0.64627231
73TTN0.64041440
74PRPF4B0.63538950
75PAK20.63028059
76BMX0.61668774
77PDGFRB0.60912646
78FGFR10.60415442
79CAMK10.59893596
80EPHA20.59369344
81PTK20.59264110
82ERBB20.58150013
83RPS6KL10.56949044
84RPS6KC10.56949044
85DYRK1A0.56881964
86HIPK20.56071302
87SGK10.54557787
88CSNK1A1L0.53737603
89PRKCZ0.53362588
90RPS6KA30.53285525
91FYN0.52795732
92MAPK100.52712796
93EPHB10.51160097
94CAMK40.50799859
95ERN10.50751277
96SIK10.48360767
97TNK20.48023637
98WNK10.46688490
99PLK20.45998228
100CDK40.45329520
101CDK90.45153769
102FES0.44617003
103MAP2K20.44569864
104RPS6KB20.44483385
105MAP3K60.44168472
106SGK4940.43524291
107SGK2230.43524291
108MAPK80.43513775
109PRKD20.43242287
110PDPK10.42613959
111CDK60.42565722
112CDK70.42402137
113NEK60.42266868
114CDK20.42265651
115MAPK90.41848113
116MAP3K10.41749657
117CSNK1D0.41546701
118PRKD10.41471883
119FGFR30.41063555
120PRKAA10.40816486
121BRD40.40078016
122LATS10.39907125
123RPS6KA60.39847562
124GSK3B0.39470134
125CDK10.38165895
126MAPK110.37192708
127PASK0.35929238
128MAPK120.34333717

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.38203351
2Synaptic vesicle cycle_Homo sapiens_hsa047212.12352829
3Circadian entrainment_Homo sapiens_hsa047132.09943465
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07121919
5Long-term potentiation_Homo sapiens_hsa047202.04060869
6Nicotine addiction_Homo sapiens_hsa050331.97384686
7GABAergic synapse_Homo sapiens_hsa047271.93564239
8Glutamatergic synapse_Homo sapiens_hsa047241.84458203
9Insulin secretion_Homo sapiens_hsa049111.82718930
10Dopaminergic synapse_Homo sapiens_hsa047281.78960786
11Morphine addiction_Homo sapiens_hsa050321.75740420
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73637178
13Amphetamine addiction_Homo sapiens_hsa050311.71595763
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71163070
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70595187
16Cholinergic synapse_Homo sapiens_hsa047251.70106892
17Type II diabetes mellitus_Homo sapiens_hsa049301.65197412
18Gastric acid secretion_Homo sapiens_hsa049711.59179081
19Salivary secretion_Homo sapiens_hsa049701.58499341
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57665839
21Lysine degradation_Homo sapiens_hsa003101.53031679
22Glioma_Homo sapiens_hsa052141.48881428
23Oxytocin signaling pathway_Homo sapiens_hsa049211.47308915
24Estrogen signaling pathway_Homo sapiens_hsa049151.41860525
25Gap junction_Homo sapiens_hsa045401.41674048
26GnRH signaling pathway_Homo sapiens_hsa049121.41145824
27Cocaine addiction_Homo sapiens_hsa050301.40661175
28Axon guidance_Homo sapiens_hsa043601.38853971
29Renin secretion_Homo sapiens_hsa049241.37209169
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37133315
31mTOR signaling pathway_Homo sapiens_hsa041501.33370329
32Thyroid cancer_Homo sapiens_hsa052161.30854851
33Acute myeloid leukemia_Homo sapiens_hsa052211.30272818
34Endometrial cancer_Homo sapiens_hsa052131.30198259
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24918178
36Prostate cancer_Homo sapiens_hsa052151.22543549
37Long-term depression_Homo sapiens_hsa047301.21178332
38ErbB signaling pathway_Homo sapiens_hsa040121.20006754
39Melanogenesis_Homo sapiens_hsa049161.19213473
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17633562
41Dorso-ventral axis formation_Homo sapiens_hsa043201.16536664
42cAMP signaling pathway_Homo sapiens_hsa040241.15734090
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.15228684
44Dilated cardiomyopathy_Homo sapiens_hsa054141.14629908
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13274736
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11135436
47Taste transduction_Homo sapiens_hsa047421.10647166
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09084849
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08082990
50Prion diseases_Homo sapiens_hsa050201.07247997
51Calcium signaling pathway_Homo sapiens_hsa040201.05440069
52Colorectal cancer_Homo sapiens_hsa052101.04351233
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03320916
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98501350
55VEGF signaling pathway_Homo sapiens_hsa043700.97803686
56ECM-receptor interaction_Homo sapiens_hsa045120.97006123
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.96428765
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96264235
59Non-small cell lung cancer_Homo sapiens_hsa052230.95099650
60Serotonergic synapse_Homo sapiens_hsa047260.94313743
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94230567
62Oocyte meiosis_Homo sapiens_hsa041140.93138880
63Renal cell carcinoma_Homo sapiens_hsa052110.92739798
64Small cell lung cancer_Homo sapiens_hsa052220.91954663
65Chronic myeloid leukemia_Homo sapiens_hsa052200.89891711
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89359200
67Bladder cancer_Homo sapiens_hsa052190.88928222
68Nitrogen metabolism_Homo sapiens_hsa009100.88010280
69mRNA surveillance pathway_Homo sapiens_hsa030150.87910721
70Insulin signaling pathway_Homo sapiens_hsa049100.86909614
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85496707
72MAPK signaling pathway_Homo sapiens_hsa040100.83525585
73Hippo signaling pathway_Homo sapiens_hsa043900.83067804
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82755985
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82193423
76Choline metabolism in cancer_Homo sapiens_hsa052310.81469283
77Wnt signaling pathway_Homo sapiens_hsa043100.80445107
78Thyroid hormone synthesis_Homo sapiens_hsa049180.79480619
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.79410531
80Glucagon signaling pathway_Homo sapiens_hsa049220.79292332
81Rap1 signaling pathway_Homo sapiens_hsa040150.79239167
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.76543018
83Basal cell carcinoma_Homo sapiens_hsa052170.75219104
84Pathways in cancer_Homo sapiens_hsa052000.74887356
85Proteoglycans in cancer_Homo sapiens_hsa052050.74249501
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74211619
87Hedgehog signaling pathway_Homo sapiens_hsa043400.74168526
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71346940
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71034623
90Pancreatic secretion_Homo sapiens_hsa049720.70974351
91Focal adhesion_Homo sapiens_hsa045100.70247169
92B cell receptor signaling pathway_Homo sapiens_hsa046620.69670135
93FoxO signaling pathway_Homo sapiens_hsa040680.69391175
94Endocytosis_Homo sapiens_hsa041440.68694477
95Amoebiasis_Homo sapiens_hsa051460.67493669
96Adherens junction_Homo sapiens_hsa045200.66365372
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65307309
98Prolactin signaling pathway_Homo sapiens_hsa049170.65069679
99Melanoma_Homo sapiens_hsa052180.65052919
100HIF-1 signaling pathway_Homo sapiens_hsa040660.63711772
101Tight junction_Homo sapiens_hsa045300.63420559
102AMPK signaling pathway_Homo sapiens_hsa041520.62730893
103Insulin resistance_Homo sapiens_hsa049310.62108100
104Ras signaling pathway_Homo sapiens_hsa040140.61884492
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61437491
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60125419
107Notch signaling pathway_Homo sapiens_hsa043300.59763964
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58265524
109Pancreatic cancer_Homo sapiens_hsa052120.57670944
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56338738
111Phototransduction_Homo sapiens_hsa047440.53803750
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53763245
113Inositol phosphate metabolism_Homo sapiens_hsa005620.53534821
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.53189986
115Platelet activation_Homo sapiens_hsa046110.53093264
116MicroRNAs in cancer_Homo sapiens_hsa052060.50979412
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50932518

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