PRRC2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)6.07259731
2nuclear pore complex assembly (GO:0051292)5.74047908
3nuclear pore organization (GO:0006999)5.11642099
4pre-miRNA processing (GO:0031054)4.71409442
5regulation of RNA export from nucleus (GO:0046831)4.32169638
6pore complex assembly (GO:0046931)4.32149345
7positive regulation by host of viral transcription (GO:0043923)4.27597971
8regulation of DNA endoreduplication (GO:0032875)4.15150752
9histone H3-K4 trimethylation (GO:0080182)4.12059057
10cytoplasmic mRNA processing body assembly (GO:0033962)4.08475525
11monoubiquitinated protein deubiquitination (GO:0035520)4.03023846
12DNA strand renaturation (GO:0000733)4.01388124
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.93780792
14histone H3-K4 methylation (GO:0051568)3.65908491
15regulation of histone H3-K27 methylation (GO:0061085)3.61433496
16kinetochore organization (GO:0051383)3.57489785
17negative regulation of histone methylation (GO:0031061)3.55847763
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.53087363
19negative regulation of translation, ncRNA-mediated (GO:0040033)3.53087363
20regulation of translation, ncRNA-mediated (GO:0045974)3.53087363
21negative regulation of DNA repair (GO:0045738)3.51389611
22glucocorticoid receptor signaling pathway (GO:0042921)3.47809758
23peptidyl-lysine trimethylation (GO:0018023)3.47007932
24regulation of nucleobase-containing compound transport (GO:0032239)3.46579121
25regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.40726228
26positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.40726228
27peptidyl-lysine dimethylation (GO:0018027)3.38410565
28N-terminal protein amino acid acetylation (GO:0006474)3.30356648
29regulation of centrosome duplication (GO:0010824)3.30128221
30sister chromatid cohesion (GO:0007062)3.26882959
31regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.24732331
32positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.24732331
33histone deubiquitination (GO:0016578)3.21598018
34regulation of posttranscriptional gene silencing (GO:0060147)3.20649458
35regulation of gene silencing by miRNA (GO:0060964)3.20649458
36regulation of gene silencing by RNA (GO:0060966)3.20649458
37regulation of histone H3-K9 methylation (GO:0051570)3.18415453
38histone lysine methylation (GO:0034968)3.15214579
39NLS-bearing protein import into nucleus (GO:0006607)3.13380284
40antigen processing and presentation via MHC class Ib (GO:0002475)3.08879794
41chromatin silencing (GO:0006342)3.08078646
42histone H3-K9 methylation (GO:0051567)3.05373383
43regulation of mitotic spindle organization (GO:0060236)3.04007483
44regulation of sister chromatid cohesion (GO:0007063)3.00704165
45kinetochore assembly (GO:0051382)2.98235680
46DNA methylation (GO:0006306)2.98022713
47DNA alkylation (GO:0006305)2.98022713
48regulation of centrosome cycle (GO:0046605)2.96842634
49mitotic nuclear envelope disassembly (GO:0007077)2.96536681
50corticosteroid receptor signaling pathway (GO:0031958)2.96044149
51collecting duct development (GO:0072044)2.95313276
52positive regulation of protein export from nucleus (GO:0046827)2.95287813
53sister chromatid segregation (GO:0000819)2.93953274
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90159648
55positive regulation of mitotic sister chromatid separation (GO:1901970)2.90159648
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90159648
57phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89685903
58heterochromatin organization (GO:0070828)2.88613843
59regulation of spindle organization (GO:0090224)2.88528934
60regulation of centriole replication (GO:0046599)2.87548431
61negative regulation of histone modification (GO:0031057)2.87234064
62embryonic hemopoiesis (GO:0035162)2.83859046
63mitotic chromosome condensation (GO:0007076)2.83738206
64positive regulation of mRNA catabolic process (GO:0061014)2.81863072
65negative regulation of chromatin modification (GO:1903309)2.81404766
66membrane disassembly (GO:0030397)2.80302597
67nuclear envelope disassembly (GO:0051081)2.80302597
68protein K48-linked deubiquitination (GO:0071108)2.80154647
69protein export from nucleus (GO:0006611)2.79816524
70histone methylation (GO:0016571)2.79204911
71alternative mRNA splicing, via spliceosome (GO:0000380)2.78756274
72peptidyl-lysine methylation (GO:0018022)2.76730485
73snRNA transcription (GO:0009301)2.76706317
74DNA geometric change (GO:0032392)2.73684887
75DNA duplex unwinding (GO:0032508)2.72648291
76dosage compensation (GO:0007549)2.72462835
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.72338159
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.72040382
79modulation by host of viral transcription (GO:0043921)2.71956526
80modulation by host of symbiont transcription (GO:0052472)2.71956526
81paraxial mesoderm development (GO:0048339)2.71660742
82RNA stabilization (GO:0043489)2.71275971
83mRNA stabilization (GO:0048255)2.71275971
84DNA unwinding involved in DNA replication (GO:0006268)2.70572084
85positive regulation of gene expression, epigenetic (GO:0045815)2.70496502
86coronary vasculature morphogenesis (GO:0060977)2.70236951
87regulation of histone H3-K4 methylation (GO:0051569)2.69299299
88histone mRNA catabolic process (GO:0071044)2.68248030
89regulation of gene expression by genetic imprinting (GO:0006349)2.68230464
90histone H4-K12 acetylation (GO:0043983)2.67802585
91histone H3-K9 modification (GO:0061647)2.66153543
92regulation of histone methylation (GO:0031060)2.65831209
93TOR signaling (GO:0031929)2.65611744
94chromatin assembly (GO:0031497)2.63163785
95negative regulation of histone acetylation (GO:0035067)2.61182226
96histone H3-K9 demethylation (GO:0033169)2.60441650
97establishment of protein localization to Golgi (GO:0072600)2.59837684
98gene silencing by RNA (GO:0031047)2.59474984
99replication fork processing (GO:0031297)2.58075819
100histone H4-K16 acetylation (GO:0043984)2.56784607
101positive regulation of histone H3-K4 methylation (GO:0051571)2.56472151
102regulation of mRNA catabolic process (GO:0061013)2.56209130
103interkinetic nuclear migration (GO:0022027)2.55574882
104protein localization to kinetochore (GO:0034501)2.55559895
105positive regulation of mRNA 3-end processing (GO:0031442)2.55268339
106modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.55141743
107V(D)J recombination (GO:0033151)2.52368591
108regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.51927067
109ncRNA catabolic process (GO:0034661)2.51888166
110regulation of NFAT protein import into nucleus (GO:0051532)2.51732769
111regulation of mRNA 3-end processing (GO:0031440)2.50574846
112positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.49917283
113histone H4 acetylation (GO:0043967)2.49549322
114regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.47894898
115nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.45554899
116histone lysine demethylation (GO:0070076)2.45260537
117positive regulation of chromosome segregation (GO:0051984)2.45054853
118positive regulation of cell cycle checkpoint (GO:1901978)2.44040637
119hippo signaling (GO:0035329)2.43096489
120head development (GO:0060322)2.42716064
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41299614
122DNA topological change (GO:0006265)2.40901921
123mitotic sister chromatid segregation (GO:0000070)2.40551800
124mRNA splice site selection (GO:0006376)2.40213481
125gene silencing (GO:0016458)2.39661618
126regulation of stem cell maintenance (GO:2000036)2.39546850
127stress granule assembly (GO:0034063)2.37684386
128nucleosome disassembly (GO:0006337)2.36600999
129protein-DNA complex disassembly (GO:0032986)2.36600999
130histone H3-K36 demethylation (GO:0070544)2.32365027
131meiotic chromosome segregation (GO:0045132)2.31454125
132histone demethylation (GO:0016577)2.31295146
133DNA conformation change (GO:0071103)2.30297587
134regulation of protein polyubiquitination (GO:1902914)2.30226543
135regulation of mRNA stability (GO:0043488)2.29460798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.18434341
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.92498677
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.66387568
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.17106201
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64177469
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52358345
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.43667908
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.32391823
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02739292
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73195873
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58587964
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.32203900
13MYC_22102868_ChIP-Seq_BL_Human2.31811931
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29845683
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27036745
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.13882344
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12930833
18HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.96294362
19FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.81194396
20PKCTHETA_26484144_Chip-Seq_BREAST_Human1.77853043
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76013549
22SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74838850
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67735886
24CIITA_25753668_ChIP-Seq_RAJI_Human1.64202026
25AR_21909140_ChIP-Seq_LNCAP_Human1.61061873
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60678865
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60355293
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.56676217
29* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52989635
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52009682
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49099696
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.44545143
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41198499
34TCF7_22412390_ChIP-Seq_EML_Mouse1.40929554
35EWS_26573619_Chip-Seq_HEK293_Human1.38401701
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36982547
37FUS_26573619_Chip-Seq_HEK293_Human1.35076462
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34078062
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.33701549
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30727627
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28495878
42TP53_16413492_ChIP-PET_HCT116_Human1.27464054
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27179756
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.26913760
45AR_21572438_ChIP-Seq_LNCaP_Human1.23985690
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23224212
47ISL1_27105846_Chip-Seq_CPCs_Mouse1.21216062
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17970328
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16720264
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16586562
51AHR_22903824_ChIP-Seq_MCF-7_Human1.16160730
52* BRD4_25478319_ChIP-Seq_HGPS_Human1.13171547
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12152511
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11186699
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09819363
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09570492
57KDM2B_26808549_Chip-Seq_DND41_Human1.08193699
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06906290
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06082466
60STAT3_23295773_ChIP-Seq_U87_Human1.04519231
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03970917
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03663213
63RUNX_20019798_ChIP-Seq_JUKART_Human1.03439309
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03317227
65MYB_26560356_Chip-Seq_TH1_Human1.02846134
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01129226
67CHD1_26751641_Chip-Seq_LNCaP_Human0.99067755
68KDM2B_26808549_Chip-Seq_JURKAT_Human0.98013545
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97519979
70CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97175017
71EZH2_22144423_ChIP-Seq_EOC_Human0.97008702
72MYB_26560356_Chip-Seq_TH2_Human0.96659153
73POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95573669
74TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95132736
75ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94896808
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94352457
77PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93663910
78TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93528574
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92800632
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91855758
81MYC_18555785_ChIP-Seq_MESCs_Mouse0.91757644
82UTX_26944678_Chip-Seq_JUKART_Human0.91630869
83KDM2B_26808549_Chip-Seq_K562_Human0.91177373
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90791570
85TCF4_23295773_ChIP-Seq_U87_Human0.89780966
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.89448715
87KDM5A_27292631_Chip-Seq_BREAST_Human0.89351889
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89148165
89NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89081091
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87921089
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86655087
92ELK1_19687146_ChIP-ChIP_HELA_Human0.86423244
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85867208
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.85590999
95AR_19668381_ChIP-Seq_PC3_Human0.84721009
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84719883
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84602382
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84129867
99VDR_21846776_ChIP-Seq_THP-1_Human0.83705052
100WT1_19549856_ChIP-ChIP_CCG9911_Human0.83064076
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82530319
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82031243
103NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81951115
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.81126482
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80786446
106RING1B_27294783_Chip-Seq_NPCs_Mouse0.80460637
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80097708
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78509200
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78509200
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78509200
111GF1B_26923725_Chip-Seq_HPCs_Mouse0.78498164
112POU5F1_16518401_ChIP-PET_MESCs_Mouse0.78427540
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.77161329
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76526170
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76381263
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76240020
117SOX9_26525672_Chip-Seq_HEART_Mouse0.75739165
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75579781
119TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75430717
120TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.74591242
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.74050005
122MAF_26560356_Chip-Seq_TH1_Human0.73677663
123GATA6_25053715_ChIP-Seq_YYC3_Human0.73093544
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.72765856
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71924317
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71924317
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71643429
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.71615448
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.71239389
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71000022
131KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70853690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.47625074
2MP0008057_abnormal_DNA_replication2.98468092
3MP0010094_abnormal_chromosome_stability2.71553229
4MP0005076_abnormal_cell_differentiation2.61402704
5MP0003121_genomic_imprinting2.54707532
6MP0008877_abnormal_DNA_methylation2.52843346
7MP0003787_abnormal_imprinting2.32970401
8MP0010352_gastrointestinal_tract_polyps2.29458196
9MP0003111_abnormal_nucleus_morphology2.23640762
10MP0003077_abnormal_cell_cycle2.21202082
11MP0002396_abnormal_hematopoietic_system1.94284634
12MP0003693_abnormal_embryo_hatching1.87289470
13MP0004808_abnormal_hematopoietic_stem1.86348273
14MP0001873_stomach_inflammation1.85399040
15MP0003123_paternal_imprinting1.83920076
16MP0008007_abnormal_cellular_replicative1.82091879
17MP0004957_abnormal_blastocyst_morpholog1.80227435
18MP0010307_abnormal_tumor_latency1.78768994
19MP0003890_abnormal_embryonic-extraembry1.77667545
20MP0001293_anophthalmia1.70690466
21MP0003878_abnormal_ear_physiology1.69012828
22MP0005377_hearing/vestibular/ear_phenot1.69012828
23MP0002084_abnormal_developmental_patter1.68164387
24MP0000350_abnormal_cell_proliferation1.68070865
25MP0008058_abnormal_DNA_repair1.66364710
26MP0004197_abnormal_fetal_growth/weight/1.64573797
27MP0003122_maternal_imprinting1.62782719
28MP0001348_abnormal_lacrimal_gland1.60813396
29MP0005380_embryogenesis_phenotype1.55474965
30MP0001672_abnormal_embryogenesis/_devel1.55474965
31MP0003984_embryonic_growth_retardation1.55017357
32MP0002088_abnormal_embryonic_growth/wei1.53013698
33MP0010030_abnormal_orbit_morphology1.52235400
34MP0009053_abnormal_anal_canal1.52004447
35MP0003937_abnormal_limbs/digits/tail_de1.51881886
36MP0002085_abnormal_embryonic_tissue1.51289600
37MP0001730_embryonic_growth_arrest1.50871230
38MP0003385_abnormal_body_wall1.50556836
39MP0003935_abnormal_craniofacial_develop1.47649940
40MP0009703_decreased_birth_body1.46749065
41MP0000428_abnormal_craniofacial_morphol1.45775221
42MP0000733_abnormal_muscle_development1.45431025
43MP0002086_abnormal_extraembryonic_tissu1.43165243
44MP0000432_abnormal_head_morphology1.37472061
45MP0005408_hypopigmentation1.36642537
46MP0001697_abnormal_embryo_size1.36113221
47MP0001188_hyperpigmentation1.34558948
48MP0004134_abnormal_chest_morphology1.34193305
49MP0002938_white_spotting1.33751555
50MP0003941_abnormal_skin_development1.32783385
51MP0002166_altered_tumor_susceptibility1.31691840
52MP0000516_abnormal_urinary_system1.30643637
53MP0005367_renal/urinary_system_phenotyp1.30643637
54MP0000703_abnormal_thymus_morphology1.29958289
55MP0001849_ear_inflammation1.27822251
56MP0000537_abnormal_urethra_morphology1.27074843
57MP0004381_abnormal_hair_follicle1.25832362
58MP0003755_abnormal_palate_morphology1.25593487
59MP0003567_abnormal_fetal_cardiomyocyte1.22278424
60MP0002006_tumorigenesis1.19366140
61MP0002925_abnormal_cardiovascular_devel1.19179934
62MP0000383_abnormal_hair_follicle1.18910661
63MP0009672_abnormal_birth_weight1.13845645
64MP0000579_abnormal_nail_morphology1.13268269
65MP0003115_abnormal_respiratory_system1.12288911
66MP0003763_abnormal_thymus_physiology1.12018425
67MP0009278_abnormal_bone_marrow1.11454693
68MP0000566_synostosis1.10680809
69MP0001286_abnormal_eye_development1.09166339
70MP0002092_abnormal_eye_morphology1.09114689
71MP0005409_darkened_coat_color1.07127955
72MP0008995_early_reproductive_senescence1.05853090
73MP0008932_abnormal_embryonic_tissue1.05308233
74MP0004185_abnormal_adipocyte_glucose1.03930629
75MP0002697_abnormal_eye_size1.02624935
76MP0006292_abnormal_olfactory_placode1.02444266
77MP0002116_abnormal_craniofacial_bone1.01821412
78MP0002080_prenatal_lethality1.01597302
79MP0005248_abnormal_Harderian_gland1.00471547
80MP0004264_abnormal_extraembryonic_tissu0.99087896
81MP0002009_preneoplasia0.97937051
82MP0010678_abnormal_skin_adnexa0.97910748
83MP0009250_abnormal_appendicular_skeleto0.97181163
84MP0000778_abnormal_nervous_system0.97050296
85MP0003300_gastrointestinal_ulcer0.96328867
86MP0005174_abnormal_tail_pigmentation0.95858500
87MP0003861_abnormal_nervous_system0.94412251
88MP0003705_abnormal_hypodermis_morpholog0.93871740
89MP0001299_abnormal_eye_distance/0.91533171
90MP0001915_intracranial_hemorrhage0.90830585
91MP0004742_abnormal_vestibular_system0.89999316
92MP0002109_abnormal_limb_morphology0.89095147
93MP0003566_abnormal_cell_adhesion0.88572394
94MP0003942_abnormal_urinary_system0.88450723
95MP0002233_abnormal_nose_morphology0.88247726
96MP0005187_abnormal_penis_morphology0.87780046
97MP0000049_abnormal_middle_ear0.86024266
98MP0002177_abnormal_outer_ear0.85666079
99MP0003119_abnormal_digestive_system0.84887444
100MP0005623_abnormal_meninges_morphology0.84725964
101MP0008961_abnormal_basal_metabolism0.83782008
102MP0003943_abnormal_hepatobiliary_system0.82725629
103MP0002081_perinatal_lethality0.81867173
104MP0002932_abnormal_joint_morphology0.81609985
105MP0005423_abnormal_somatic_nervous0.81605524
106MP0003091_abnormal_cell_migration0.81546228
107MP0001545_abnormal_hematopoietic_system0.80384013
108MP0005397_hematopoietic_system_phenotyp0.80384013
109MP0000534_abnormal_ureter_morphology0.78654451
110MP0002398_abnormal_bone_marrow0.77644711
111MP0001784_abnormal_fluid_regulation0.77477894
112MP0002114_abnormal_axial_skeleton0.75990831
113MP0000266_abnormal_heart_morphology0.75563498
114MP0002095_abnormal_skin_pigmentation0.74949518
115MP0000313_abnormal_cell_death0.74586425
116MP0003936_abnormal_reproductive_system0.74117125
117MP0009115_abnormal_fat_cell0.72946864
118MP0000631_abnormal_neuroendocrine_gland0.71395354
119MP0000427_abnormal_hair_cycle0.69696161
120MP0002184_abnormal_innervation0.67171139
121MP0002102_abnormal_ear_morphology0.66946704
122MP0000371_diluted_coat_color0.65745948
123MP0001346_abnormal_lacrimal_gland0.65315510
124MP0004233_abnormal_muscle_weight0.65043967
125MP0000627_abnormal_mammary_gland0.64815384
126MP0001186_pigmentation_phenotype0.64648204
127MP0002152_abnormal_brain_morphology0.63574031
128MP0000955_abnormal_spinal_cord0.60813787
129MP0008770_decreased_survivor_rate0.59548802
130MP0005621_abnormal_cell_physiology0.58791029

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.31913994
2Abnormality of the fingertips (HP:0001211)3.94204174
3Short 4th metacarpal (HP:0010044)3.84001951
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.84001951
5Long eyelashes (HP:0000527)3.56528528
6Urethral obstruction (HP:0000796)3.15588609
7Trigonocephaly (HP:0000243)2.90062698
8Abnormality of the nasal septum (HP:0000419)2.89296165
9Narrow palate (HP:0000189)2.88723211
10Ectopic kidney (HP:0000086)2.69384375
11Supernumerary ribs (HP:0005815)2.62228737
12Increased nuchal translucency (HP:0010880)2.58961214
13Abnormality of the 4th metacarpal (HP:0010012)2.55771521
14Macroorchidism (HP:0000053)2.55109766
15Diastasis recti (HP:0001540)2.54963740
16Deep philtrum (HP:0002002)2.53665895
17Lip pit (HP:0100267)2.51246652
18Protruding tongue (HP:0010808)2.46323192
19Deviation of the thumb (HP:0009603)2.44182930
20Proximal placement of thumb (HP:0009623)2.42513411
21Supernumerary bones of the axial skeleton (HP:0009144)2.36819964
22Esophageal atresia (HP:0002032)2.36038310
23Spinal cord lesions (HP:0100561)2.35015130
24Syringomyelia (HP:0003396)2.35015130
25Acute myeloid leukemia (HP:0004808)2.34612623
26Medulloblastoma (HP:0002885)2.34321158
27Abnormal number of incisors (HP:0011064)2.31946931
28Abnormal hair whorl (HP:0010721)2.29173086
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28189870
30Broad thumb (HP:0011304)2.27512700
31Prominent nose (HP:0000448)2.27222126
32Midline defect of the nose (HP:0004122)2.26681853
33Abnormality of the labia minora (HP:0012880)2.24713149
34Chromsome breakage (HP:0040012)2.23453283
35Preauricular skin tag (HP:0000384)2.23393813
36Anal stenosis (HP:0002025)2.21847130
37Neonatal hypoglycemia (HP:0001998)2.20381191
38Abnormality of the parietal bone (HP:0002696)2.19374324
39Truncal obesity (HP:0001956)2.17626112
40Overlapping toe (HP:0001845)2.17389402
41Neoplasm of the oral cavity (HP:0100649)2.16650271
42Obsessive-compulsive behavior (HP:0000722)2.13755814
43Absent frontal sinuses (HP:0002688)2.11583687
44Abnormality of chromosome segregation (HP:0002916)2.10406845
45Partial agenesis of the corpus callosum (HP:0001338)2.09377543
46Deep palmar crease (HP:0006191)2.09326209
47Wide intermamillary distance (HP:0006610)2.04509335
48Papillary thyroid carcinoma (HP:0002895)2.03821373
49Hypoplastic labia majora (HP:0000059)2.02233438
50Limited elbow extension (HP:0001377)2.01883548
51Oligodactyly (hands) (HP:0001180)2.00977279
52Patellar aplasia (HP:0006443)2.00792098
53Low anterior hairline (HP:0000294)2.00580022
54Shallow orbits (HP:0000586)1.99968864
55Hypoplasia of the maxilla (HP:0000327)1.99118854
56Astrocytoma (HP:0009592)1.96147084
57Abnormality of the astrocytes (HP:0100707)1.96147084
58Highly arched eyebrow (HP:0002553)1.95477927
59Clubbing of toes (HP:0100760)1.95412399
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.95268689
61Skull defect (HP:0001362)1.95158618
62Sparse lateral eyebrow (HP:0005338)1.94213418
63Homocystinuria (HP:0002156)1.92895704
64Abnormality of homocysteine metabolism (HP:0010919)1.92895704
65Neoplasm of the adrenal cortex (HP:0100641)1.91439109
66Renovascular hypertension (HP:0100817)1.91020501
67Abnormality of the incisor (HP:0000676)1.90443160
68Obstructive sleep apnea (HP:0002870)1.89817260
69Tapered finger (HP:0001182)1.89172686
70Nephroblastoma (Wilms tumor) (HP:0002667)1.87964721
71Acute lymphatic leukemia (HP:0006721)1.87335186
72Increased number of teeth (HP:0011069)1.86876576
73Patellar dislocation (HP:0002999)1.85962285
74Broad phalanges of the hand (HP:0009768)1.85753851
75Smooth philtrum (HP:0000319)1.84364614
76Chin dimple (HP:0010751)1.83362684
77Cutis marmorata (HP:0000965)1.83222892
78Thick eyebrow (HP:0000574)1.82494772
79Ependymoma (HP:0002888)1.82324285
80Abnormality of the labia majora (HP:0012881)1.80802235
81Aplasia/Hypoplasia of the patella (HP:0006498)1.80227515
82Glioma (HP:0009733)1.79918327
83Dysmetric saccades (HP:0000641)1.79437836
8411 pairs of ribs (HP:0000878)1.77930087
85Skin tags (HP:0010609)1.77745224
86Abnormality of the columella (HP:0009929)1.77076588
87Dislocated radial head (HP:0003083)1.75941149
88Low posterior hairline (HP:0002162)1.75168447
89Depressed nasal tip (HP:0000437)1.74953918
90Broad finger (HP:0001500)1.74006405
91Renal duplication (HP:0000075)1.73682468
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.73149514
93Abnormal pancreas size (HP:0012094)1.73077451
94Broad palm (HP:0001169)1.72382895
95Hepatoblastoma (HP:0002884)1.72002063
96Facial hemangioma (HP:0000329)1.71980235
97Abnormality of the phalanges of the hallux (HP:0010057)1.71849220
98Progressive cerebellar ataxia (HP:0002073)1.71728431
99Colon cancer (HP:0003003)1.71718225
100Embryonal renal neoplasm (HP:0011794)1.71683518
101Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70732449
102Rhabdomyosarcoma (HP:0002859)1.70135283
103Intestinal fistula (HP:0100819)1.70042395
104T lymphocytopenia (HP:0005403)1.69913734
105Microtia (HP:0008551)1.69656147
106Sandal gap (HP:0001852)1.69075753
107Elfin facies (HP:0004428)1.68601676
108Intestinal malrotation (HP:0002566)1.68439907
1092-3 toe syndactyly (HP:0004691)1.68161027
110Abnormality of incisor morphology (HP:0011063)1.68141476
111Atresia of the external auditory canal (HP:0000413)1.67178323
112Heterotopia (HP:0002282)1.67036774
113Neoplasm of striated muscle (HP:0009728)1.66601645
114Malignant gastrointestinal tract tumors (HP:0006749)1.66451134
115Gastrointestinal carcinoma (HP:0002672)1.66451134
116High anterior hairline (HP:0009890)1.66174749
117Abnormality of the radial head (HP:0003995)1.65631411
118Oligodontia (HP:0000677)1.65115146
119Synophrys (HP:0000664)1.64134132
120Hyperacusis (HP:0010780)1.63414016
121Cafe-au-lait spot (HP:0000957)1.62703460
122Broad phalanx (HP:0006009)1.62594159
123Aqueductal stenosis (HP:0002410)1.61944531
124Vertebral arch anomaly (HP:0008438)1.61907111
125Sparse scalp hair (HP:0002209)1.60391540
126Chronic otitis media (HP:0000389)1.59498938
127Oligodactyly (HP:0012165)1.59460543
128Birth length less than 3rd percentile (HP:0003561)1.59304599
129Genetic anticipation (HP:0003743)1.58772586
130Blepharitis (HP:0000498)1.57896840
131Macrotia (HP:0000400)1.57303918
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57152609
133Rib fusion (HP:0000902)1.57130125
134Shawl scrotum (HP:0000049)1.56398109
135Underdeveloped nasal alae (HP:0000430)1.55761487
136Abnormality of the carotid arteries (HP:0005344)1.55658859
137Abnormality of the antihelix (HP:0009738)1.55303276
138Transitional cell carcinoma of the bladder (HP:0006740)1.53642653
139Vesicoureteral reflux (HP:0000076)1.52076684
140Abnormality of T cell number (HP:0011839)1.51428686
141Abnormality of chromosome stability (HP:0003220)1.51425859
142Sacral dimple (HP:0000960)1.50518413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.95889498
2BRD44.07466804
3CDC73.53658385
4CAMK1G2.75873217
5CAMK1D2.72707345
6LATS12.56304326
7MKNK12.35222469
8MKNK22.34822783
9TNIK1.90123633
10NEK21.85401522
11PNCK1.82064173
12TXK1.65936376
13ATR1.60134211
14MTOR1.55835484
15CDK61.48965622
16MAP3K101.47850580
17FGFR41.43093549
18DMPK1.40524399
19FGFR21.40090034
20FGFR31.39318965
21ATM1.35751778
22NUAK11.35654802
23STK31.34703423
24* CHEK11.30069939
25SIK21.28749894
26PLK31.24798651
27CDK71.22257739
28ALK1.22148129
29CDK91.20432386
30STK101.20209231
31TSSK61.18408486
32PDGFRB1.16947918
33SRPK11.15918583
34EEF2K1.14264894
35SIK31.12648597
36CHEK21.10277741
37FGFR11.06449894
38CDK41.05592154
39TTK1.05561068
40CDK21.03863017
41WNK11.00640897
42SGK4940.99886795
43SGK2230.99886795
44CASK0.99529862
45MAP3K90.98887058
46CHUK0.94860495
47SGK30.94544168
48CSNK1A1L0.93150482
49MAP4K10.92980861
50PRKCH0.91252755
51CDK10.90420583
52STK40.90360672
53RPS6KA40.88078026
54CDK30.85327937
55MELK0.84208719
56MAPK140.82549217
57PLK40.82491611
58SGK20.82245368
59AURKB0.81497340
60PLK10.75822149
61CSNK1D0.75363556
62RPS6KB20.75179099
63ICK0.74922583
64TRIB30.74732172
65RIPK10.73864604
66GSK3B0.71558876
67CDC42BPA0.71257280
68CSNK1E0.70733330
69PDGFRA0.70534805
70ERBB30.70437443
71PRKDC0.70313909
72TAOK30.68957147
73AKT30.68710884
74EIF2AK20.68187760
75ITK0.67801181
76MAPK100.65273517
77CAMKK10.62998349
78MAPK10.62121142
79SIK10.62037587
80PIK3CA0.61213725
81MAPK80.59766109
82CAMK40.59660414
83BRSK20.59035467
84TAF10.58336708
85PTK20.58063282
86PASK0.56763378
87JAK10.56323443
88MAP3K70.56087728
89JAK30.55496841
90PIM10.55495895
91YES10.54538644
92AKT10.54206628
93WNK40.53607577
94WEE10.53478323
95NLK0.53226991
96MARK20.51490979
97SMG10.50831609
98PRKAA20.49126195
99BMPR1B0.48906048
100MARK30.47243190
101TGFBR10.46135985
102SGK10.45399296
103PLK20.44960876
104HCK0.44843943
105ERBB20.44394453
106CSNK1G10.44169594
107EPHA30.44142695
108BTK0.43284514
109PAK20.42984572
110RPS6KB10.42575535
111RPS6KA30.41904428
112CLK10.40857023
113PAK30.39590441
114TAOK10.39312205
115ACVR1B0.39179970
116MAP3K80.39146819
117PKN20.38705063
118MAP3K140.38652485
119HIPK20.38550288
120CAMK10.38226434
121NME10.37973212
122LRRK20.37728557
123DYRK20.36601546
124TTN0.35672974
125FRK0.35056081
126SCYL20.34274907
127MAPK90.33949446
128TYRO30.31767050
129TEC0.30623109

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041101.98927905
2Non-homologous end-joining_Homo sapiens_hsa034501.90137850
3Lysine degradation_Homo sapiens_hsa003101.80336767
4mRNA surveillance pathway_Homo sapiens_hsa030151.79065229
5MicroRNAs in cancer_Homo sapiens_hsa052061.75097168
6RNA transport_Homo sapiens_hsa030131.73147827
7Spliceosome_Homo sapiens_hsa030401.64918444
8Adherens junction_Homo sapiens_hsa045201.63502372
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55158414
10Mismatch repair_Homo sapiens_hsa034301.54930860
11Basal cell carcinoma_Homo sapiens_hsa052171.54922586
12Primary immunodeficiency_Homo sapiens_hsa053401.47618187
13Fanconi anemia pathway_Homo sapiens_hsa034601.45542339
14RNA degradation_Homo sapiens_hsa030181.39209683
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36688568
16Chronic myeloid leukemia_Homo sapiens_hsa052201.32039601
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31069294
18Prostate cancer_Homo sapiens_hsa052151.30588217
19Colorectal cancer_Homo sapiens_hsa052101.29443355
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29278337
21T cell receptor signaling pathway_Homo sapiens_hsa046601.27785842
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27665460
23HTLV-I infection_Homo sapiens_hsa051661.26113793
24Wnt signaling pathway_Homo sapiens_hsa043101.25393110
25DNA replication_Homo sapiens_hsa030301.24409483
26Notch signaling pathway_Homo sapiens_hsa043301.20721108
27TGF-beta signaling pathway_Homo sapiens_hsa043501.19629758
28Small cell lung cancer_Homo sapiens_hsa052221.18491257
29Homologous recombination_Homo sapiens_hsa034401.17219883
30Viral myocarditis_Homo sapiens_hsa054161.15082954
31Hippo signaling pathway_Homo sapiens_hsa043901.14428981
32Herpes simplex infection_Homo sapiens_hsa051681.14215311
33Thyroid cancer_Homo sapiens_hsa052161.12706313
34Endometrial cancer_Homo sapiens_hsa052131.12435985
35Proteoglycans in cancer_Homo sapiens_hsa052051.12017304
36Hedgehog signaling pathway_Homo sapiens_hsa043401.09895878
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.08587773
38Viral carcinogenesis_Homo sapiens_hsa052031.08443719
39Antigen processing and presentation_Homo sapiens_hsa046121.04290194
40Dorso-ventral axis formation_Homo sapiens_hsa043201.04051160
41p53 signaling pathway_Homo sapiens_hsa041151.01890769
42Pathways in cancer_Homo sapiens_hsa052001.01309282
43Base excision repair_Homo sapiens_hsa034100.98705885
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96796710
45Basal transcription factors_Homo sapiens_hsa030220.95395577
46Hepatitis B_Homo sapiens_hsa051610.94836782
47mTOR signaling pathway_Homo sapiens_hsa041500.94710578
48VEGF signaling pathway_Homo sapiens_hsa043700.94365695
49Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94307811
50Non-small cell lung cancer_Homo sapiens_hsa052230.93708384
51Oocyte meiosis_Homo sapiens_hsa041140.92085866
52Pancreatic cancer_Homo sapiens_hsa052120.91055987
53Acute myeloid leukemia_Homo sapiens_hsa052210.90812990
54B cell receptor signaling pathway_Homo sapiens_hsa046620.89419218
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87812740
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87496241
57Epstein-Barr virus infection_Homo sapiens_hsa051690.86923729
58Measles_Homo sapiens_hsa051620.86748560
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.86639769
60Renal cell carcinoma_Homo sapiens_hsa052110.85518972
61Glioma_Homo sapiens_hsa052140.85483142
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.84739882
63FoxO signaling pathway_Homo sapiens_hsa040680.84384166
64Selenocompound metabolism_Homo sapiens_hsa004500.82996095
65RNA polymerase_Homo sapiens_hsa030200.82971861
66ErbB signaling pathway_Homo sapiens_hsa040120.82698175
67One carbon pool by folate_Homo sapiens_hsa006700.81889185
68Hematopoietic cell lineage_Homo sapiens_hsa046400.81526117
69Focal adhesion_Homo sapiens_hsa045100.80643049
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78914290
71Nucleotide excision repair_Homo sapiens_hsa034200.78343460
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78307949
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78225381
74Osteoclast differentiation_Homo sapiens_hsa043800.76062235
75Axon guidance_Homo sapiens_hsa043600.75845910
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.75321257
77Thyroid hormone synthesis_Homo sapiens_hsa049180.75079430
78Circadian rhythm_Homo sapiens_hsa047100.74612961
79Melanogenesis_Homo sapiens_hsa049160.74578721
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74193936
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73998090
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.73130997
83ECM-receptor interaction_Homo sapiens_hsa045120.72034342
84Melanoma_Homo sapiens_hsa052180.71307922
85Type II diabetes mellitus_Homo sapiens_hsa049300.70550261
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.68886711
87Toxoplasmosis_Homo sapiens_hsa051450.68622501
88Influenza A_Homo sapiens_hsa051640.68613216
89MAPK signaling pathway_Homo sapiens_hsa040100.68143945
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67821182
91Rap1 signaling pathway_Homo sapiens_hsa040150.67576842
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67553471
93Platelet activation_Homo sapiens_hsa046110.67531654
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66626951
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66307313
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65515127
97Long-term potentiation_Homo sapiens_hsa047200.65459409
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64739277
99TNF signaling pathway_Homo sapiens_hsa046680.62531617
100Estrogen signaling pathway_Homo sapiens_hsa049150.61792675
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59258709
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58827854
103Bladder cancer_Homo sapiens_hsa052190.58634011
104Tight junction_Homo sapiens_hsa045300.56686124
105Prolactin signaling pathway_Homo sapiens_hsa049170.56513112
106Chemokine signaling pathway_Homo sapiens_hsa040620.56466262
107Leishmaniasis_Homo sapiens_hsa051400.56408791
108Choline metabolism in cancer_Homo sapiens_hsa052310.56143105
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56111109
110Ribosome_Homo sapiens_hsa030100.55923776
111Ras signaling pathway_Homo sapiens_hsa040140.55922086
112Glucagon signaling pathway_Homo sapiens_hsa049220.54908918
113Hepatitis C_Homo sapiens_hsa051600.54391259
114Insulin resistance_Homo sapiens_hsa049310.53655896
115Inositol phosphate metabolism_Homo sapiens_hsa005620.51876657
116HIF-1 signaling pathway_Homo sapiens_hsa040660.51499772
117cAMP signaling pathway_Homo sapiens_hsa040240.51428499
118Apoptosis_Homo sapiens_hsa042100.45910942
119GnRH signaling pathway_Homo sapiens_hsa049120.43154885
120Cholinergic synapse_Homo sapiens_hsa047250.41807541

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