PRRG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.47125373
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06221236
3L-phenylalanine catabolic process (GO:0006559)6.06221236
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.93917459
5L-phenylalanine metabolic process (GO:0006558)5.93917459
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.27186883
7intestinal epithelial cell development (GO:0060576)5.24244964
8aromatic amino acid family catabolic process (GO:0009074)5.09297549
9GDP-mannose metabolic process (GO:0019673)4.90309045
10sulfur amino acid catabolic process (GO:0000098)4.78706672
11cysteine metabolic process (GO:0006534)4.49002390
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.48442649
13regulation of water loss via skin (GO:0033561)4.44610734
14glyoxylate metabolic process (GO:0046487)4.34457997
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32959505
16tryptophan catabolic process (GO:0006569)4.29931009
17indole-containing compound catabolic process (GO:0042436)4.29931009
18indolalkylamine catabolic process (GO:0046218)4.29931009
19intestinal cholesterol absorption (GO:0030299)4.28140631
20tryptophan metabolic process (GO:0006568)4.22122828
21bile acid biosynthetic process (GO:0006699)4.20935247
22peptidyl-glutamic acid carboxylation (GO:0017187)4.19445311
23protein carboxylation (GO:0018214)4.19445311
24establishment of skin barrier (GO:0061436)4.15230012
25phenol-containing compound catabolic process (GO:0019336)4.11052092
26alpha-linolenic acid metabolic process (GO:0036109)4.09241636
27kynurenine metabolic process (GO:0070189)4.04471226
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03619527
29keratinocyte development (GO:0003334)4.02843572
30urea cycle (GO:0000050)3.99112402
31urea metabolic process (GO:0019627)3.99112402
32calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.97192183
33high-density lipoprotein particle remodeling (GO:0034375)3.91242475
34aromatic amino acid family metabolic process (GO:0009072)3.86327209
35multicellular organismal water homeostasis (GO:0050891)3.81157120
36bile acid metabolic process (GO:0008206)3.79899958
37regulation of triglyceride catabolic process (GO:0010896)3.78480300
38phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.76050600
39positive regulation of cellular amine metabolic process (GO:0033240)3.74674907
40nitrogen cycle metabolic process (GO:0071941)3.74654642
41negative regulation of fibrinolysis (GO:0051918)3.74352817
42triglyceride homeostasis (GO:0070328)3.69401488
43acylglycerol homeostasis (GO:0055090)3.69401488
44regulation of cholesterol esterification (GO:0010872)3.64909500
45positive regulation of triglyceride lipase activity (GO:0061365)3.64846131
46positive regulation of lipoprotein lipase activity (GO:0051006)3.64846131
47aldehyde catabolic process (GO:0046185)3.64278264
48complement activation, alternative pathway (GO:0006957)3.64100886
49fat-soluble vitamin biosynthetic process (GO:0042362)3.63660032
50hemidesmosome assembly (GO:0031581)3.61187348
51homocysteine metabolic process (GO:0050667)3.54422244
52phospholipid efflux (GO:0033700)3.54375970
53plasma lipoprotein particle clearance (GO:0034381)3.53639935
54tyrosine metabolic process (GO:0006570)3.53260669
55regulation of cholesterol homeostasis (GO:2000188)3.52386123
56regulation of fibrinolysis (GO:0051917)3.52288850
57lysine catabolic process (GO:0006554)3.51802797
58lysine metabolic process (GO:0006553)3.51802797
59regulation of protein activation cascade (GO:2000257)3.51332718
60intestinal absorption (GO:0050892)3.49859035
61amino-acid betaine metabolic process (GO:0006577)3.48728286
62serine family amino acid catabolic process (GO:0009071)3.48619772
63reverse cholesterol transport (GO:0043691)3.46668826
64bile acid and bile salt transport (GO:0015721)3.46375588
65plasma lipoprotein particle remodeling (GO:0034369)3.45739152
66protein-lipid complex remodeling (GO:0034368)3.45739152
67macromolecular complex remodeling (GO:0034367)3.45739152
68glutathione biosynthetic process (GO:0006750)3.40056983
69cellular ketone body metabolic process (GO:0046950)3.39581005
70negative regulation of cholesterol transport (GO:0032375)3.38817758
71negative regulation of sterol transport (GO:0032372)3.38817758
72fatty acid beta-oxidation (GO:0006635)3.36011046
73alpha-amino acid catabolic process (GO:1901606)3.34000504
74regulation of complement activation (GO:0030449)3.32114285
75drug transmembrane transport (GO:0006855)3.30430288
76urate metabolic process (GO:0046415)3.28173336
77cellular modified amino acid catabolic process (GO:0042219)3.25861697
78fatty acid oxidation (GO:0019395)3.23589184
79cellular amino acid catabolic process (GO:0009063)3.21441509
80water homeostasis (GO:0030104)3.21368101
81valine metabolic process (GO:0006573)3.21322368
82ribosomal small subunit biogenesis (GO:0042274)3.21220474
83cholesterol efflux (GO:0033344)3.19660586
84protein autoprocessing (GO:0016540)3.18900624
85lipid oxidation (GO:0034440)3.17240326
86fatty acid catabolic process (GO:0009062)3.15841956
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15624513
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14993212
89rRNA modification (GO:0000154)3.13272749
90indolalkylamine metabolic process (GO:0006586)3.12548539
91regulation of viral release from host cell (GO:1902186)3.12276233
92positive regulation of triglyceride metabolic process (GO:0090208)3.11617742
93coenzyme catabolic process (GO:0009109)3.09142261
94cholesterol homeostasis (GO:0042632)3.08735084
95proline metabolic process (GO:0006560)3.08302240
96plasma lipoprotein particle assembly (GO:0034377)3.07129847
97arginine metabolic process (GO:0006525)3.06620572
98flavonoid metabolic process (GO:0009812)3.06519190
99cofactor catabolic process (GO:0051187)3.05932452
100organic acid catabolic process (GO:0016054)3.05304523
101carboxylic acid catabolic process (GO:0046395)3.05304523
102sterol homeostasis (GO:0055092)3.04693537
103ATP synthesis coupled proton transport (GO:0015986)3.03962401
104energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03962401
105monocarboxylic acid catabolic process (GO:0072329)3.03159815
106electron transport chain (GO:0022900)3.01999943
107diol metabolic process (GO:0034311)3.01986496
108cobalamin metabolic process (GO:0009235)3.01891945
109proline biosynthetic process (GO:0006561)3.01748360
110Golgi transport vesicle coating (GO:0048200)3.00497448
111COPI coating of Golgi vesicle (GO:0048205)3.00497448
112respiratory electron transport chain (GO:0022904)3.00109633
113glandular epithelial cell differentiation (GO:0002067)2.99616103
114cellular biogenic amine catabolic process (GO:0042402)2.98281728
115amine catabolic process (GO:0009310)2.98281728
116serine family amino acid metabolic process (GO:0009069)2.97680613
117benzene-containing compound metabolic process (GO:0042537)2.97346107
118positive regulation of fatty acid biosynthetic process (GO:0045723)2.97297876
119positive regulation of epidermal cell differentiation (GO:0045606)2.96165913
120drug catabolic process (GO:0042737)2.93887995
121lipoprotein metabolic process (GO:0042157)2.93721999
122ethanol oxidation (GO:0006069)2.93423107
123positive regulation of lipid catabolic process (GO:0050996)2.93090763
124tight junction assembly (GO:0070830)2.90030864
125cellular glucuronidation (GO:0052695)2.89273075
126nonribosomal peptide biosynthetic process (GO:0019184)2.89244424
127regulation of cellular amino acid metabolic process (GO:0006521)2.88260633
128zinc ion transmembrane transport (GO:0071577)2.87801152
129ketone body metabolic process (GO:1902224)2.87635726
130primary alcohol catabolic process (GO:0034310)2.87542139
131very-low-density lipoprotein particle assembly (GO:0034379)2.87373325
132acute-phase response (GO:0006953)2.87033460
133drug transport (GO:0015893)2.83591478
134fibrinolysis (GO:0042730)2.83157913
135glutathione derivative metabolic process (GO:1901685)2.83002379
136glutathione derivative biosynthetic process (GO:1901687)2.83002379
137imidazole-containing compound metabolic process (GO:0052803)2.82688685
138drug metabolic process (GO:0017144)2.82645498
139short-chain fatty acid metabolic process (GO:0046459)2.81682101
140phenylpropanoid metabolic process (GO:0009698)2.81271251
141ncRNA 3-end processing (GO:0043628)2.80774334
142respiratory chain complex IV assembly (GO:0008535)2.73241676
143nucleotide-sugar biosynthetic process (GO:0009226)2.72806630
144glucuronate metabolic process (GO:0019585)2.71492960
145uronic acid metabolic process (GO:0006063)2.71492960
146regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.71390738
147cytochrome complex assembly (GO:0017004)2.70325745
148protein maturation by protein folding (GO:0022417)2.69345322
149auditory receptor cell differentiation (GO:0042491)2.68249530
150biotin metabolic process (GO:0006768)2.67724377
151transcytosis (GO:0045056)2.67709294
152phosphate ion homeostasis (GO:0055062)2.66842660
153trivalent inorganic anion homeostasis (GO:0072506)2.66842660
154positive regulation of epidermis development (GO:0045684)2.63378853
155sphingomyelin metabolic process (GO:0006684)2.62796413
156regulation of keratinocyte differentiation (GO:0045616)2.62780361
157protein localization to endoplasmic reticulum (GO:0070972)2.60433618
158gap junction assembly (GO:0016264)2.59287302
159dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.59102527
160nucleotide transmembrane transport (GO:1901679)2.58907663
161ectoderm development (GO:0007398)2.56985686
162pseudouridine synthesis (GO:0001522)2.56836348
163tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56796729
164RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56796729
165protein targeting to ER (GO:0045047)2.54978230
166hydrogen peroxide catabolic process (GO:0042744)2.54038580
167SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.52778961
168O-glycan processing (GO:0016266)2.52286684
169sphingosine metabolic process (GO:0006670)2.51772480
170negative regulation of transcription by competitive promoter binding (GO:0010944)2.51234515
171regulation of cell proliferation involved in kidney development (GO:1901722)2.50066352
172cotranslational protein targeting to membrane (GO:0006613)2.48739207
173rRNA methylation (GO:0031167)2.46097577
174nucleoside transmembrane transport (GO:1901642)2.44317108
175regulation of mitochondrial translation (GO:0070129)2.44284355
176establishment of protein localization to endoplasmic reticulum (GO:0072599)2.44230055
177positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.44089263
178regulation of epidermal cell differentiation (GO:0045604)2.42782390
179purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.42455235
1803-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.42455235
181regulation of apoptotic process involved in morphogenesis (GO:1902337)2.42194146
182glutathione metabolic process (GO:0006749)2.41666735
183vesicle targeting (GO:0006903)2.41629971
184vitamin transport (GO:0051180)2.41537857
185ER overload response (GO:0006983)2.41428175
186columnar/cuboidal epithelial cell development (GO:0002066)2.41407600
187negative regulation of keratinocyte proliferation (GO:0010839)2.41304852
188nitric oxide biosynthetic process (GO:0006809)2.37640066
189positive regulation of Cdc42 GTPase activity (GO:0043089)2.37068980
190hydrogen peroxide metabolic process (GO:0042743)2.35223993
191L-alpha-amino acid transmembrane transport (GO:1902475)2.34698908
192translation (GO:0006412)2.34320403
193NADH metabolic process (GO:0006734)2.33820269
194nucleobase-containing small molecule interconversion (GO:0015949)2.32271358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.90616068
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.94123472
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.38969202
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.49238867
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.38774525
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.34633093
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.14061145
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.71300262
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.28136932
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.63078457
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43266614
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.39295994
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32920328
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27529319
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16146759
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13400423
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10624656
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.09505003
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07773247
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06565553
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05142192
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93259766
23ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.84893121
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78952954
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.75269016
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73482702
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.72527371
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69772473
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66862458
30CLOCK_20551151_ChIP-Seq_293T_Human1.63177403
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.55443984
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.54024395
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51728316
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.50049737
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48959564
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48655641
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46465257
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.45126442
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.43927171
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42924304
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42647292
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41227989
43ZNF263_19887448_ChIP-Seq_K562_Human1.41075012
44ELF5_23300383_ChIP-Seq_T47D_Human1.40917749
45GATA1_22025678_ChIP-Seq_K562_Human1.35752401
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35718166
47KDM5A_27292631_Chip-Seq_BREAST_Human1.35626124
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35305041
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33801422
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33801422
51XRN2_22483619_ChIP-Seq_HELA_Human1.33675635
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32850257
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31456960
54GABP_19822575_ChIP-Seq_HepG2_Human1.30777813
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28570300
56TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27272375
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.27260907
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26625908
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26198463
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.24344142
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.22166619
62LXR_22292898_ChIP-Seq_THP-1_Human1.21586456
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19409153
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18965837
65DCP1A_22483619_ChIP-Seq_HELA_Human1.18215441
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16793407
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16238816
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15876293
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15679232
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15525152
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14386554
72TP63_22573176_ChIP-Seq_HFKS_Human1.13530440
73GATA4_25053715_ChIP-Seq_YYC3_Human1.12676239
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12131985
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.09505618
76RACK7_27058665_Chip-Seq_MCF-7_Human1.09463376
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09440117
78BCOR_27268052_Chip-Seq_Bcells_Human1.07679693
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07394935
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07280938
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.07156976
82AR_21909140_ChIP-Seq_LNCAP_Human1.06416096
83KLF5_25053715_ChIP-Seq_YYC3_Human1.05468357
84P68_20966046_ChIP-Seq_HELA_Human1.05233213
85* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04772382
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04204860
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04049669
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03619680
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.03310241
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02929108
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02247540
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01268433
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01135192
94SOX2_20726797_ChIP-Seq_SW620_Human1.00519268
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00118376
96CHD1_26751641_Chip-Seq_LNCaP_Human1.00076090
97* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00025119
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99644050
99* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99180870
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99083769
101SMC4_20622854_ChIP-Seq_HELA_Human0.98075253
102ERG_21242973_ChIP-ChIP_JURKAT_Human0.97922506
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97264009
104STAT1_20625510_ChIP-Seq_HELA_Human0.96523641
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95561114
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94108474
107RARB_24833708_ChIP-Seq_LIVER_Mouse0.93434492
108* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92720053
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92443481
110GATA6_25053715_ChIP-Seq_YYC3_Human0.91520194
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.90122567
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89287071
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88887489
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.87868276
115HNF4A_19822575_ChIP-Seq_HepG2_Human0.87609089
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.87315194
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86855278
118CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86853191
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86577265
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.86564916
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84402143
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83894564
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83231987
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82800362
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82065411
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81389027
127CTCF_20526341_ChIP-Seq_ESCs_Human0.81328198
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80558115
129SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80292649
130BCL6_27268052_Chip-Seq_Bcells_Human0.79466019
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.79323883
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78679770
133CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78029790
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.78012269
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77870294
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77221890
137ATF3_27146783_Chip-Seq_COLON_Human0.76400369
138SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75527749
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74749521
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.74717661
141* ELF1_20517297_ChIP-Seq_JURKAT_Human0.73801055
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73139303
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72857885
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72005077
145* E2F1_20622854_ChIP-Seq_HELA_Human0.71849250
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71704138
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71159685
148BP1_19119308_ChIP-ChIP_Hs578T_Human0.70402885
149MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70364273
150IRF8_27001747_Chip-Seq_BMDM_Mouse0.70231811
151P300_27268052_Chip-Seq_Bcells_Human0.70190801
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.69205356
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69205356
154KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69205356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.36180434
2MP0010234_abnormal_vibrissa_follicle6.22557247
3MP0005360_urolithiasis5.83789076
4MP0005365_abnormal_bile_salt4.87177464
5MP0005085_abnormal_gallbladder_physiolo4.66976192
6MP0009379_abnormal_foot_pigmentation4.51178196
7MP0003806_abnormal_nucleotide_metabolis4.22172985
8MP0008875_abnormal_xenobiotic_pharmacok3.74203407
9MP0005083_abnormal_biliary_tract3.39502268
10MP0009840_abnormal_foam_cell3.23739674
11MP0003195_calcinosis3.07204606
12MP0003252_abnormal_bile_duct2.97723374
13MP0009780_abnormal_chondrocyte_physiolo2.94275186
14MP0001666_abnormal_nutrient_absorption2.87533760
15MP0005501_abnormal_skin_physiology2.80332267
16MP0005409_darkened_coat_color2.77674230
17MP0010329_abnormal_lipoprotein_level2.70831236
18MP0005332_abnormal_amino_acid2.39609827
19MP0003136_yellow_coat_color2.37619018
20MP0004019_abnormal_vitamin_homeostasis2.32420681
21MP0003191_abnormal_cellular_cholesterol2.30562149
22MP0010678_abnormal_skin_adnexa2.25658073
23MP0002837_dystrophic_cardiac_calcinosis2.18923681
24MP0002138_abnormal_hepatobiliary_system2.17035814
25MP0000579_abnormal_nail_morphology2.11533589
26MP0003941_abnormal_skin_development2.10118068
27MP0004381_abnormal_hair_follicle1.99294029
28MP0002118_abnormal_lipid_homeostasis1.85028042
29MP0009643_abnormal_urine_homeostasis1.84646860
30MP0002163_abnormal_gland_morphology1.82938107
31MP0000609_abnormal_liver_physiology1.81166387
32MP0002909_abnormal_adrenal_gland1.79717505
33MP0005058_abnormal_lysosome_morphology1.70088958
34MP0001216_abnormal_epidermal_layer1.68225328
35MP0005379_endocrine/exocrine_gland_phen1.67817781
36MP0005451_abnormal_body_composition1.67372470
37MP0003186_abnormal_redox_activity1.66889991
38MP0003693_abnormal_embryo_hatching1.64117928
39MP0000383_abnormal_hair_follicle1.63355618
40MP0003868_abnormal_feces_composition1.62471187
41MP0005319_abnormal_enzyme/_coenzyme1.61839171
42MP0000372_irregular_coat_pigmentation1.58334705
43MP0003724_increased_susceptibility_to1.54986330
44MP0001188_hyperpigmentation1.54916754
45MP0010771_integument_phenotype1.50830130
46MP0001764_abnormal_homeostasis1.48759772
47MP0005220_abnormal_exocrine_pancreas1.37651802
48MP0005636_abnormal_mineral_homeostasis1.34260450
49MP0004043_abnormal_pH_regulation1.34085713
50MP0001664_abnormal_digestion1.26420938
51MP0003436_decreased_susceptibility_to1.24482930
52MP0001881_abnormal_mammary_gland1.24323393
53MP0005084_abnormal_gallbladder_morpholo1.23310328
54MP0005584_abnormal_enzyme/coenzyme_acti1.21335577
55MP0000377_abnormal_hair_follicle1.21128614
56MP0003656_abnormal_erythrocyte_physiolo1.20023511
57MP0001756_abnormal_urination1.17276070
58MP0000627_abnormal_mammary_gland1.14192667
59MP0001873_stomach_inflammation1.12939336
60MP0008469_abnormal_protein_level1.12652193
61MP0001849_ear_inflammation1.11165157
62MP0002277_abnormal_respiratory_mucosa1.10614320
63MP0005670_abnormal_white_adipose1.09905811
64MP0000467_abnormal_esophagus_morphology1.08763986
65MP0002060_abnormal_skin_morphology1.08758683
66MP0010352_gastrointestinal_tract_polyps1.08225713
67MP0003705_abnormal_hypodermis_morpholog1.07022019
68MP0002796_impaired_skin_barrier1.06929194
69MP0000598_abnormal_liver_morphology1.06166610
70MP0000003_abnormal_adipose_tissue1.05508292
71MP0002254_reproductive_system_inflammat1.04944288
72MP0004957_abnormal_blastocyst_morpholog1.04923358
73MP0009764_decreased_sensitivity_to1.04497134
74MP0004782_abnormal_surfactant_physiolog1.02979473
75MP0009785_altered_susceptibility_to1.01530924
76MP0002234_abnormal_pharynx_morphology0.98480941
77MP0005408_hypopigmentation0.98324921
78MP0002693_abnormal_pancreas_physiology0.96615256
79MP0002160_abnormal_reproductive_system0.96598591
80MP0001944_abnormal_pancreas_morphology0.96560628
81MP0000427_abnormal_hair_cycle0.95576707
82MP0002078_abnormal_glucose_homeostasis0.95401217
83MP0003011_delayed_dark_adaptation0.95114108
84MP0002166_altered_tumor_susceptibility0.93465120
85MP0000015_abnormal_ear_pigmentation0.93383146
86MP0009642_abnormal_blood_homeostasis0.92096607
87MP0009763_increased_sensitivity_to0.89823541
88MP0005395_other_phenotype0.89389365
89MP0000490_abnormal_crypts_of0.89176474
90MP0005167_abnormal_blood-brain_barrier0.85772365
91MP0000678_abnormal_parathyroid_gland0.85752661
92MP0000367_abnormal_coat/_hair0.84834786
93MP0002136_abnormal_kidney_physiology0.84040552
94MP0006036_abnormal_mitochondrial_physio0.83469706
95MP0000762_abnormal_tongue_morphology0.83089448
96MP0005377_hearing/vestibular/ear_phenot0.81352304
97MP0003878_abnormal_ear_physiology0.81352304
98MP0003183_abnormal_peptide_metabolism0.79841804
99MP0009697_abnormal_copulation0.79245116
100MP0002653_abnormal_ependyma_morphology0.78634805
101MP0004147_increased_porphyrin_level0.76257671
102MP0004264_abnormal_extraembryonic_tissu0.75999774
103MP0005464_abnormal_platelet_physiology0.75829129
104MP0005334_abnormal_fat_pad0.75203230
105MP0006082_CNS_inflammation0.74752429
106MP0001845_abnormal_inflammatory_respons0.74677153
107MP0003045_fibrosis0.74463245
108MP0000477_abnormal_intestine_morphology0.74301238
109MP0000462_abnormal_digestive_system0.73481978
110MP0003879_abnormal_hair_cell0.73298225
111MP0001191_abnormal_skin_condition0.72854335
112MP0003283_abnormal_digestive_organ0.72524887
113MP0002168_other_aberrant_phenotype0.71740852
114MP0000566_synostosis0.71094558
115MP0003453_abnormal_keratinocyte_physiol0.70898798
116MP0000470_abnormal_stomach_morphology0.70152043
117MP0002736_abnormal_nociception_after0.70130007
118MP0001533_abnormal_skeleton_physiology0.69642643
119MP0005376_homeostasis/metabolism_phenot0.69498953
120MP0009931_abnormal_skin_appearance0.68192076
121MP0002419_abnormal_innate_immunity0.67253177
122MP0005647_abnormal_sex_gland0.66410794
123MP0005075_abnormal_melanosome_morpholog0.66193546
124MP0000604_amyloidosis0.65391444
125MP0005025_abnormal_response_to0.64069625
126MP0001765_abnormal_ion_homeostasis0.62566351
127MP0002098_abnormal_vibrissa_morphology0.62410871
128MP0003638_abnormal_response/metabolism_0.61496065
129MP0009765_abnormal_xenobiotic_induced0.61302066
130MP0002928_abnormal_bile_duct0.61011902
131MP0002877_abnormal_melanocyte_morpholog0.60803958
132MP0000613_abnormal_salivary_gland0.60195885
133MP0008004_abnormal_stomach_pH0.60135002
134MP0010155_abnormal_intestine_physiology0.60090004
135MP0001661_extended_life_span0.59450203
136MP0001542_abnormal_bone_strength0.59069643
137MP0005666_abnormal_adipose_tissue0.58956290
138MP0002876_abnormal_thyroid_physiology0.58716066
139MP0002295_abnormal_pulmonary_circulatio0.55944996
140MP0005448_abnormal_energy_balance0.55932421
141MP0003718_maternal_effect0.54651391
142MP0003953_abnormal_hormone_level0.54358117
143MP0005535_abnormal_body_temperature0.54123698
144MP0000249_abnormal_blood_vessel0.53305178
145MP0008260_abnormal_autophagy0.52911415
146MP0002132_abnormal_respiratory_system0.52778689
147MP0003172_abnormal_lysosome_physiology0.52764253
148MP0010386_abnormal_urinary_bladder0.52009944
149MP0002148_abnormal_hypersensitivity_rea0.51145385
150MP0005165_increased_susceptibility_to0.51128673
151MP0002971_abnormal_brown_adipose0.51104547
152MP0000685_abnormal_immune_system0.50839741
153MP0003075_altered_response_to0.50639563
154MP0000538_abnormal_urinary_bladder0.50383364

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.31198863
2Intrahepatic cholestasis (HP:0001406)4.99053139
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.95598543
4Prolonged partial thromboplastin time (HP:0003645)4.85802859
5Xanthomatosis (HP:0000991)4.83733832
6Hypoglycemic coma (HP:0001325)4.71682651
7Deep venous thrombosis (HP:0002625)4.51184315
8Hypobetalipoproteinemia (HP:0003563)4.41656252
9Pili torti (HP:0003777)4.19172607
10Right ventricular cardiomyopathy (HP:0011663)4.14863516
11Joint hemorrhage (HP:0005261)3.87608160
12Testicular atrophy (HP:0000029)3.83856682
13Generalized aminoaciduria (HP:0002909)3.74223123
14Hyperlipoproteinemia (HP:0010980)3.73132763
15Abnormality of the intrinsic pathway (HP:0010989)3.70298223
16Ketosis (HP:0001946)3.61517199
17Hyperammonemia (HP:0001987)3.61201099
18Abnormality of fatty-acid metabolism (HP:0004359)3.60343218
19Hyperglycinuria (HP:0003108)3.59597286
20Abnormality of the common coagulation pathway (HP:0010990)3.58925560
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.58085929
22Complement deficiency (HP:0004431)3.56852743
23Hyperinsulinemic hypoglycemia (HP:0000825)3.53079181
24Hypoglycemic seizures (HP:0002173)3.51934627
25Fat malabsorption (HP:0002630)3.39686664
26Hypolipoproteinemia (HP:0010981)3.33384099
27Hyperglycinemia (HP:0002154)3.30554625
28Abnormality of purine metabolism (HP:0004352)3.29436400
29Ketoacidosis (HP:0001993)3.28366371
30Gout (HP:0001997)3.24309805
31Lip pit (HP:0100267)3.24115384
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21979818
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21979818
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.20936007
35Vacuolated lymphocytes (HP:0001922)3.18779108
36Abnormality of serine family amino acid metabolism (HP:0010894)3.18258540
37Abnormality of glycine metabolism (HP:0010895)3.18258540
38Symptomatic seizures (HP:0011145)3.14413631
39Abnormality of vitamin metabolism (HP:0100508)3.13261793
40Sparse eyelashes (HP:0000653)3.12746774
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.12064020
42Amelogenesis imperfecta (HP:0000705)3.10348815
43Systemic lupus erythematosus (HP:0002725)3.09987228
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.05785531
45Abnormality of nucleobase metabolism (HP:0010932)3.03809957
46Conjugated hyperbilirubinemia (HP:0002908)3.02151353
47Plantar hyperkeratosis (HP:0007556)3.00573269
48Late onset (HP:0003584)2.96025953
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94007409
50Dicarboxylic aciduria (HP:0003215)2.94007409
51Epidermoid cyst (HP:0200040)2.93566721
52Abnormal hair laboratory examination (HP:0003328)2.93534432
53J-shaped sella turcica (HP:0002680)2.88222232
54Hypoalphalipoproteinemia (HP:0003233)2.86222758
55Type I transferrin isoform profile (HP:0003642)2.80016132
56Abnormality of complement system (HP:0005339)2.79820311
57Abnormality of vitamin B metabolism (HP:0004340)2.78640637
58Congenital ichthyosiform erythroderma (HP:0007431)2.78048339
59Hyperphosphatemia (HP:0002905)2.77201022
60Fragile nails (HP:0001808)2.76878067
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.75525201
62Concave nail (HP:0001598)2.70032922
63Onycholysis (HP:0001806)2.65763997
64Chronic bronchitis (HP:0004469)2.61048652
65Recurrent gram-negative bacterial infections (HP:0005420)2.60773948
66Hyperbilirubinemia (HP:0002904)2.60061450
67Steatorrhea (HP:0002570)2.58029016
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.54900343
69Hypercholesterolemia (HP:0003124)2.54548756
70Abnormality of pyrimidine metabolism (HP:0004353)2.52557071
71Palmoplantar hyperkeratosis (HP:0000972)2.48819782
72Abnormality of methionine metabolism (HP:0010901)2.48136509
73Malnutrition (HP:0004395)2.46639560
74Methylmalonic acidemia (HP:0002912)2.45561641
75Hyperglycemia (HP:0003074)2.41475317
76Hyperparathyroidism (HP:0000843)2.39618039
77Flat acetabular roof (HP:0003180)2.38705125
78Megaloblastic anemia (HP:0001889)2.37420906
79Hypotrichosis (HP:0001006)2.36812491
80Lethargy (HP:0001254)2.36333738
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.36272889
82Woolly hair (HP:0002224)2.35808424
83Irritability (HP:0000737)2.35181277
84Conjunctival hamartoma (HP:0100780)2.34706105
85Myocardial infarction (HP:0001658)2.33560872
86Abnormality of urine glucose concentration (HP:0011016)2.32755432
87Glycosuria (HP:0003076)2.32755432
88Hyperthyroidism (HP:0000836)2.31968070
89Pancreatitis (HP:0001733)2.31417359
90Metabolic acidosis (HP:0001942)2.30886238
91Esophageal varix (HP:0002040)2.28043941
92Abnormality of nail color (HP:0100643)2.27557115
93Proximal tubulopathy (HP:0000114)2.26703572
94Glomerulonephritis (HP:0000099)2.26547167
95Hypoplasia of the uterus (HP:0000013)2.26385845
96Aplasia/hypoplasia of the uterus (HP:0008684)2.25961958
97Delayed CNS myelination (HP:0002188)2.24092588
98Vascular calcification (HP:0004934)2.23972424
99Amyloidosis (HP:0011034)2.22563354
100Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21802360
101Abnormal protein N-linked glycosylation (HP:0012347)2.21802360
102Abnormal protein glycosylation (HP:0012346)2.21802360
103Abnormal glycosylation (HP:0012345)2.21802360
104Renal Fanconi syndrome (HP:0001994)2.21156104
105Methylmalonic aciduria (HP:0012120)2.18775935
106Urinary glycosaminoglycan excretion (HP:0003541)2.17946327
107Mucopolysacchariduria (HP:0008155)2.17946327
108Abnormal enzyme/coenzyme activity (HP:0012379)2.17289191
109Alopecia of scalp (HP:0002293)2.16611633
110Tongue fasciculations (HP:0001308)2.15930072
111Skin nodule (HP:0200036)2.15912676
112Palmar hyperkeratosis (HP:0010765)2.15612388
113Hydroxyprolinuria (HP:0003080)2.15406500
114Abnormality of proline metabolism (HP:0010907)2.15406500
115Opisthotonus (HP:0002179)2.14717568
116Acute encephalopathy (HP:0006846)2.11688508
117Abnormal mitochondria in muscle tissue (HP:0008316)2.11613296
118Abnormality of magnesium homeostasis (HP:0004921)2.11612679
119Oral leukoplakia (HP:0002745)2.10792419
120Flat capital femoral epiphysis (HP:0003370)2.10721084
121Hyperphosphaturia (HP:0003109)2.10228353
122Axonal loss (HP:0003447)2.10015662
123Vomiting (HP:0002013)2.09451794
124Mitochondrial inheritance (HP:0001427)2.09316410
125Hyperuricemia (HP:0002149)2.07550970
126Increased purine levels (HP:0004368)2.07550970
127Alkalosis (HP:0001948)2.07192767
128Nausea (HP:0002018)2.06140105
129Dysostosis multiplex (HP:0000943)2.06113363
130Reduced antithrombin III activity (HP:0001976)2.05286755
131Abnormality of the dental root (HP:0006486)2.05061447
132Taurodontia (HP:0000679)2.05061447
133Abnormality of permanent molar morphology (HP:0011071)2.05061447
134Abnormality of serum amino acid levels (HP:0003112)2.04448461
135Abnormality of alkaline phosphatase activity (HP:0004379)2.04266743
136Abnormal urine phosphate concentration (HP:0012599)2.03274986
137Hepatocellular carcinoma (HP:0001402)2.02810632
138Brushfield spots (HP:0001088)2.01079616
139Rhinitis (HP:0012384)1.99862858
140Acute necrotizing encephalopathy (HP:0006965)1.99812839
141Abnormal cartilage morphology (HP:0002763)1.99655474
142Milia (HP:0001056)1.99380879
143Dehydration (HP:0001944)1.98246442
144Menorrhagia (HP:0000132)1.97316430
145Septate vagina (HP:0001153)1.95817355
146Elevated alkaline phosphatase (HP:0003155)1.95522459
147Cardiovascular calcification (HP:0011915)1.95479541
148Abnormality of polysaccharide metabolism (HP:0011012)1.95276094
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95276094
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95276094
151Abnormal respiratory motile cilium morphology (HP:0005938)1.95071863
152Abnormal respiratory epithelium morphology (HP:0012253)1.95071863
153Insulin resistance (HP:0000855)1.94774830
154Abnormality of transition element cation homeostasis (HP:0011030)1.92537113
155Hemorrhage of the eye (HP:0011885)1.92121564
156Cerebral edema (HP:0002181)1.91910829
157Microretrognathia (HP:0000308)1.91395977
158Increased hepatocellular lipid droplets (HP:0006565)1.90841291
159Abnormality of renin-angiotensin system (HP:0000847)1.90810972
160Abnormal respiratory motile cilium physiology (HP:0012261)1.89620586
161Hepatic necrosis (HP:0002605)1.88094797
162Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87364866
163Abdominal distention (HP:0003270)1.86682791
164Increased intramyocellular lipid droplets (HP:0012240)1.86663687
165Hyperactive renin-angiotensin system (HP:0000841)1.85478926
166Abnormal trabecular bone morphology (HP:0100671)1.85174515
167Hypoplasia of the pons (HP:0012110)1.84783394
168Decreased circulating renin level (HP:0003351)1.84721979
169Abnormal number of erythroid precursors (HP:0012131)1.84276063
170Hepatocellular necrosis (HP:0001404)1.83743328
171Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82380528
172Polycythemia (HP:0001901)1.81250136
173Nasolacrimal duct obstruction (HP:0000579)1.81188487
174Rough bone trabeculation (HP:0100670)1.80237633
175Abnormality of molar (HP:0011077)1.79885788
176Abnormality of molar morphology (HP:0011070)1.79885788
177Abnormality of iron homeostasis (HP:0011031)1.79861421
178Popliteal pterygium (HP:0009756)1.79047977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.92447699
2ERN14.61532997
3BCKDK4.06092853
4PIM23.18506418
5VRK23.15407378
6ARAF2.89011850
7MAPK152.81381925
8RIPK12.80347559
9INSRR2.79434640
10SMG12.60748003
11MAP3K122.48753791
12IRAK32.35791000
13LMTK22.12803702
14TLK12.09067247
15SIK12.02683138
16KDR1.96602742
17MST1R1.94118075
18MAP3K31.88748966
19NME21.88746846
20MAP3K111.88513044
21FLT31.86899764
22FGFR41.81370800
23PAK41.81067218
24TAOK31.80837995
25FRK1.76931626
26MAP2K21.65308035
27RPS6KB21.61133031
28EPHA21.59149949
29ZAK1.56937243
30BMPR1B1.55805996
31TRIB31.41763407
32BRAF1.41697913
33DYRK1B1.40239137
34TYK21.39810719
35EIF2AK11.32410619
36PTK61.30215046
37TGFBR21.25949630
38AKT31.24780926
39TEC1.24377568
40GRK11.23299468
41PIK3CG1.21078312
42MAP2K31.19755200
43WNK41.19654539
44SCYL21.16264396
45MAPKAPK31.13701760
46MET1.13106314
47ACVR1B1.12799448
48TBK11.08900144
49PRKD31.08285997
50LIMK11.02780635
51AURKA1.00607613
52BMX0.99878870
53LATS20.99876372
54TESK10.99469054
55PASK0.98152545
56CSK0.97845187
57EPHB10.96605541
58ICK0.96085605
59MAP3K140.95095338
60DAPK30.91757831
61MUSK0.91056058
62ZAP700.89129879
63DAPK10.88411591
64LATS10.85975570
65MAPK110.85372203
66MAP3K10.84357805
67IRAK40.83257459
68ABL20.81709576
69PRKD20.79861405
70BUB10.75960974
71VRK10.75882725
72TRPM70.73505661
73ILK0.71929865
74EIF2AK30.71878276
75CDK90.71163927
76TESK20.68952657
77CAMK1D0.68870535
78PKN20.65654159
79PDK20.64916201
80HIPK20.63164440
81PHKG20.63130617
82PHKG10.63130617
83BTK0.63026852
84MATK0.62374668
85IKBKB0.62063029
86JAK20.60437983
87GSK3A0.59376891
88ERBB40.59328369
89PRKCI0.58468983
90PBK0.58371216
91PTK20.58291562
92TAOK10.57666610
93PRKG20.57430344
94LRRK20.57214206
95DDR20.56908468
96MST40.56833577
97AKT20.56704470
98IRAK10.55797582
99AURKB0.54561653
100MAP3K20.52758090
101STK38L0.52339747
102TAF10.52293512
103NEK60.52151264
104MELK0.51846045
105CAMK2G0.50863951
106BLK0.50662376
107IKBKE0.49646482
108JAK10.48208784
109DYRK30.47211150
110STK380.46868496
111JAK30.46566034
112WNK30.45573003
113PDGFRA0.44511512
114STK160.44239695
115STK390.44070621
116CDK70.44054590
117CAMK2D0.41873619
118MAPKAPK20.41550934
119PIM10.39847013
120STK40.39454109
121MAPK40.39000451
122PRKD10.38743087
123MAP2K60.38148220
124PRKAA20.36912524
125EPHB20.36714178
126CSF1R0.36396745
127CSNK1A10.35516091
128STK240.35423594
129FER0.34455016
130EPHA30.34438099
131EEF2K0.34232772
132MAP4K10.34081373
133MAP2K10.33496189
134MYLK0.32690676
135PRKCD0.32626016
136CHUK0.31884428
137TTK0.30614724
138TNK20.30068274
139TAOK20.30014254
140MAP3K50.29953171
141PINK10.29435278
142EGFR0.27428960
143GRK60.27329547
144DMPK0.24897684
145NUAK10.24654484
146NME10.23852936
147RPS6KC10.23004340
148RPS6KL10.23004340
149PRKACG0.22079925
150IRAK20.21984423
151PRKCZ0.21833459
152PDPK10.21708695

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.51116316
2Proteasome_Homo sapiens_hsa030503.12069922
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.84889125
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80515067
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51620694
6Tryptophan metabolism_Homo sapiens_hsa003802.46768779
7Ribosome_Homo sapiens_hsa030102.46734959
8Fatty acid degradation_Homo sapiens_hsa000712.35899225
9Sulfur metabolism_Homo sapiens_hsa009202.30193084
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26656992
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24386977
12Folate biosynthesis_Homo sapiens_hsa007902.23612999
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20529727
14Arginine biosynthesis_Homo sapiens_hsa002202.19317002
15Complement and coagulation cascades_Homo sapiens_hsa046102.15467830
16Histidine metabolism_Homo sapiens_hsa003402.13372679
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12994059
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09338666
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07213232
20Peroxisome_Homo sapiens_hsa041462.07199531
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96897745
22Butanoate metabolism_Homo sapiens_hsa006501.93658974
23Nitrogen metabolism_Homo sapiens_hsa009101.88270133
24Fat digestion and absorption_Homo sapiens_hsa049751.81827207
25PPAR signaling pathway_Homo sapiens_hsa033201.75789113
26Propanoate metabolism_Homo sapiens_hsa006401.75604050
27Huntingtons disease_Homo sapiens_hsa050161.74642047
28beta-Alanine metabolism_Homo sapiens_hsa004101.73522058
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72286849
30Chemical carcinogenesis_Homo sapiens_hsa052041.69448106
31Staphylococcus aureus infection_Homo sapiens_hsa051501.69026250
32Sulfur relay system_Homo sapiens_hsa041221.65926060
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.65874985
34Fatty acid metabolism_Homo sapiens_hsa012121.64071314
35Parkinsons disease_Homo sapiens_hsa050121.62965575
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60992264
37Selenocompound metabolism_Homo sapiens_hsa004501.58991005
38Fatty acid elongation_Homo sapiens_hsa000621.57980699
39Caffeine metabolism_Homo sapiens_hsa002321.57696392
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55122952
41Alzheimers disease_Homo sapiens_hsa050101.53067644
42Phenylalanine metabolism_Homo sapiens_hsa003601.52558574
43Protein export_Homo sapiens_hsa030601.46767902
44Retinol metabolism_Homo sapiens_hsa008301.43892744
45Starch and sucrose metabolism_Homo sapiens_hsa005001.41974465
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.38648321
47Pyruvate metabolism_Homo sapiens_hsa006201.38128418
48Steroid biosynthesis_Homo sapiens_hsa001001.35421430
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34114900
50Bile secretion_Homo sapiens_hsa049761.30369715
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29168191
52Vitamin digestion and absorption_Homo sapiens_hsa049771.28544663
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25189158
54Tyrosine metabolism_Homo sapiens_hsa003501.24877108
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22540859
56Arginine and proline metabolism_Homo sapiens_hsa003301.22367255
57ABC transporters_Homo sapiens_hsa020101.12695095
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02298419
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00313916
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99624741
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.96853245
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95419252
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93191120
64Collecting duct acid secretion_Homo sapiens_hsa049660.92599688
65Carbon metabolism_Homo sapiens_hsa012000.91901030
66Glutathione metabolism_Homo sapiens_hsa004800.91054643
67Galactose metabolism_Homo sapiens_hsa000520.87620567
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85817700
69Biosynthesis of amino acids_Homo sapiens_hsa012300.85448802
70Linoleic acid metabolism_Homo sapiens_hsa005910.82384616
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79868260
72Fructose and mannose metabolism_Homo sapiens_hsa000510.79157506
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77201344
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75717795
75Pancreatic secretion_Homo sapiens_hsa049720.74749332
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74540654
77Other glycan degradation_Homo sapiens_hsa005110.72421749
78Pyrimidine metabolism_Homo sapiens_hsa002400.71801616
79Pentose phosphate pathway_Homo sapiens_hsa000300.71544679
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67770800
81Vitamin B6 metabolism_Homo sapiens_hsa007500.67510410
82Tight junction_Homo sapiens_hsa045300.66694268
83Nucleotide excision repair_Homo sapiens_hsa034200.66620677
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64460218
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.64347781
86Lysosome_Homo sapiens_hsa041420.63279956
87Systemic lupus erythematosus_Homo sapiens_hsa053220.63085092
88RNA polymerase_Homo sapiens_hsa030200.60719530
89Metabolic pathways_Homo sapiens_hsa011000.59381381
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58593478
91Glycerolipid metabolism_Homo sapiens_hsa005610.58118557
92Arachidonic acid metabolism_Homo sapiens_hsa005900.53583423
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53388318
94Regulation of autophagy_Homo sapiens_hsa041400.45599976
95Purine metabolism_Homo sapiens_hsa002300.45044940
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44737616
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44389190
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.44253396
99Prion diseases_Homo sapiens_hsa050200.40551036
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40071343
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39677679
102Cardiac muscle contraction_Homo sapiens_hsa042600.38069412
103Insulin resistance_Homo sapiens_hsa049310.31909925
104RNA transport_Homo sapiens_hsa030130.31272163
105Mineral absorption_Homo sapiens_hsa049780.30000085
106Legionellosis_Homo sapiens_hsa051340.29743563
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29649227
108Mismatch repair_Homo sapiens_hsa034300.28324760
109Lysine degradation_Homo sapiens_hsa003100.27501525
110Sphingolipid metabolism_Homo sapiens_hsa006000.24074441
111DNA replication_Homo sapiens_hsa030300.23312557
112One carbon pool by folate_Homo sapiens_hsa006700.22919726
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.22544994
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.20965551
115Hepatitis C_Homo sapiens_hsa051600.16960623
116Protein digestion and absorption_Homo sapiens_hsa049740.16356333
117Renin-angiotensin system_Homo sapiens_hsa046140.15552230
118Oxidative phosphorylation_Homo sapiens_hsa001900.15492563
119Fatty acid biosynthesis_Homo sapiens_hsa000610.11954605
120Pertussis_Homo sapiens_hsa051330.09155636
121Ether lipid metabolism_Homo sapiens_hsa005650.06818017
122Bladder cancer_Homo sapiens_hsa052190.06628233
123Rheumatoid arthritis_Homo sapiens_hsa053230.06363217
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06232420
125Vibrio cholerae infection_Homo sapiens_hsa051100.05499227
126N-Glycan biosynthesis_Homo sapiens_hsa005100.04771477

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