PRRG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.42936896
2embryonic process involved in female pregnancy (GO:0060136)7.79512622
3transcription from mitochondrial promoter (GO:0006390)7.13251936
4replication fork processing (GO:0031297)6.44460526
5positive regulation of protein homooligomerization (GO:0032464)6.32801152
6regulation of integrin activation (GO:0033623)6.19335598
7proline metabolic process (GO:0006560)6.14462724
8establishment of apical/basal cell polarity (GO:0035089)5.92229462
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.40524305
10regulation of protein homooligomerization (GO:0032462)5.25459922
11DNA deamination (GO:0045006)5.24287638
12mitochondrial DNA metabolic process (GO:0032042)5.22544670
13somatic hypermutation of immunoglobulin genes (GO:0016446)5.08354615
14somatic diversification of immune receptors via somatic mutation (GO:0002566)5.08354615
15establishment or maintenance of monopolar cell polarity (GO:0061339)5.05943716
16establishment of monopolar cell polarity (GO:0061162)5.05943716
17oxidative demethylation (GO:0070989)5.00455066
18DNA strand renaturation (GO:0000733)4.78063365
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.62652134
20mitotic G1 DNA damage checkpoint (GO:0031571)4.61877691
21axonemal dynein complex assembly (GO:0070286)4.46296112
22embryonic placenta development (GO:0001892)4.42348004
23poly(A)+ mRNA export from nucleus (GO:0016973)4.39195396
24cellular response to ATP (GO:0071318)4.31762890
25epithelial cilium movement (GO:0003351)4.31678417
26cilium movement (GO:0003341)4.25849623
27embryonic camera-type eye development (GO:0031076)4.21597301
28meiotic chromosome segregation (GO:0045132)4.19779612
29regulation of translational fidelity (GO:0006450)4.16745812
30mRNA cleavage (GO:0006379)4.15816368
31G1 DNA damage checkpoint (GO:0044783)4.15629932
32positive regulation of protein oligomerization (GO:0032461)4.14288360
33indole-containing compound catabolic process (GO:0042436)4.09987635
34indolalkylamine catabolic process (GO:0046218)4.09987635
35tryptophan catabolic process (GO:0006569)4.09987635
36mitotic G1/S transition checkpoint (GO:0044819)4.07159964
37cilium or flagellum-dependent cell motility (GO:0001539)3.99891205
38dosage compensation (GO:0007549)3.98411113
39face development (GO:0060324)3.96520932
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.91894311
41DNA integration (GO:0015074)3.85546072
42viral mRNA export from host cell nucleus (GO:0046784)3.84590003
43positive regulation of developmental pigmentation (GO:0048087)3.83442560
44negative regulation of cell cycle arrest (GO:0071157)3.83383413
45formation of translation preinitiation complex (GO:0001731)3.82171672
46exogenous drug catabolic process (GO:0042738)3.81643775
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.78028905
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78028905
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78028905
50regulation of posttranscriptional gene silencing (GO:0060147)3.75865798
51regulation of gene silencing by miRNA (GO:0060964)3.75865798
52regulation of gene silencing by RNA (GO:0060966)3.75865798
53apoptotic process involved in morphogenesis (GO:0060561)3.74310759
54negative regulation of JAK-STAT cascade (GO:0046426)3.74019912
55trophectodermal cell differentiation (GO:0001829)3.69710642
56nodal signaling pathway (GO:0038092)3.68814972
57regulation of RNA export from nucleus (GO:0046831)3.64403703
58L-fucose catabolic process (GO:0042355)3.63357841
59fucose catabolic process (GO:0019317)3.63357841
60L-fucose metabolic process (GO:0042354)3.63357841
61regulation of sister chromatid cohesion (GO:0007063)3.62525624
62base-excision repair (GO:0006284)3.62248783
63negative regulation of Ras GTPase activity (GO:0034261)3.61933595
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.59803650
65tryptophan metabolic process (GO:0006568)3.59066549
66regulation of protein oligomerization (GO:0032459)3.55982121
67non-recombinational repair (GO:0000726)3.55191835
68double-strand break repair via nonhomologous end joining (GO:0006303)3.55191835
69drug catabolic process (GO:0042737)3.54093350
70telomere maintenance via semi-conservative replication (GO:0032201)3.52704689
71DNA topological change (GO:0006265)3.51313390
72indolalkylamine metabolic process (GO:0006586)3.45887004
73cellular response to zinc ion (GO:0071294)3.45121206
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.42680442
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.42135289
76histone H4-K12 acetylation (GO:0043983)3.41106329
77kynurenine metabolic process (GO:0070189)3.38057953
78negative regulation of mRNA processing (GO:0050686)3.37687666
79establishment of skin barrier (GO:0061436)3.35000091
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.34511342
81activation of Rac GTPase activity (GO:0032863)3.34121155
82convergent extension (GO:0060026)3.31718433
83molting cycle (GO:0042303)3.31025368
84hair cycle (GO:0042633)3.31025368
85keratinization (GO:0031424)3.30944670
86determination of adult lifespan (GO:0008340)3.27860180
87behavioral response to nicotine (GO:0035095)3.25426276
88mitochondrial RNA metabolic process (GO:0000959)3.25283641
89DNA double-strand break processing (GO:0000729)3.25166590
90mitochondrial DNA replication (GO:0006264)3.24346752
91positive regulation by host of viral transcription (GO:0043923)3.24289373
92DNA ligation (GO:0006266)3.23555969
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.22236415
94pyrimidine-containing compound transmembrane transport (GO:0072531)3.21010778
95phosphatidylinositol acyl-chain remodeling (GO:0036149)3.20876995
96nuclear envelope reassembly (GO:0031468)3.20598962
97mitotic nuclear envelope reassembly (GO:0007084)3.20598962
98maturation of 5.8S rRNA (GO:0000460)3.19690603
99axoneme assembly (GO:0035082)3.19492800
100kinetochore assembly (GO:0051382)3.19153273
101negative regulation of protein oligomerization (GO:0032460)3.17465683
102regulation of double-strand break repair (GO:2000779)3.16457808
103base-excision repair, AP site formation (GO:0006285)3.15143669
104hydrogen peroxide biosynthetic process (GO:0050665)3.14599558
105microglial cell activation (GO:0001774)3.12989161
106negative regulation of fatty acid biosynthetic process (GO:0045717)3.12285639
107regulation of podosome assembly (GO:0071801)3.11606312
108cellular ketone body metabolic process (GO:0046950)3.03419141
109embryonic eye morphogenesis (GO:0048048)3.01089663
110regulation of memory T cell differentiation (GO:0043380)3.00795782
111negative regulation of chondrocyte differentiation (GO:0032331)2.99929995
112hypotonic response (GO:0006971)2.99887284
113regulation of DNA damage checkpoint (GO:2000001)2.98015320
114regulation of protein polyubiquitination (GO:1902914)2.97936191
115anatomical structure regression (GO:0060033)2.96856492
116termination of RNA polymerase II transcription (GO:0006369)2.96109304
117glutamine family amino acid biosynthetic process (GO:0009084)2.96067010
118alkaloid metabolic process (GO:0009820)2.95533160
119positive regulation of DNA repair (GO:0045739)2.93774092
120labyrinthine layer development (GO:0060711)2.92309275
121keratinocyte development (GO:0003334)2.91378677
122regulation of water loss via skin (GO:0033561)2.90462807
123telomere maintenance via recombination (GO:0000722)2.89700188
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88355354
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88355354
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.88355354
127modulation by symbiont of host immune response (GO:0052553)2.88355354
128positive regulation by symbiont of host defense response (GO:0052509)2.88355354
129modulation by symbiont of host defense response (GO:0052031)2.88355354
130reactive oxygen species biosynthetic process (GO:1903409)2.88086840
131glial cell migration (GO:0008347)2.87709976
132DNA demethylation (GO:0080111)2.86087064
133kinetochore organization (GO:0051383)2.85445531
134negative regulation of RNA splicing (GO:0033119)2.84432797
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83973177
136DNA strand elongation involved in DNA replication (GO:0006271)2.82941935
137regulation of hippo signaling (GO:0035330)2.82224744
138positive regulation of chromosome segregation (GO:0051984)2.81647496
139macrophage activation involved in immune response (GO:0002281)2.79661161
140auditory receptor cell stereocilium organization (GO:0060088)2.79492821
141regulation of interferon-beta biosynthetic process (GO:0045357)2.79256200
142neutrophil activation (GO:0042119)2.77046358
143negative regulation of B cell mediated immunity (GO:0002713)2.73451340
144negative regulation of immunoglobulin mediated immune response (GO:0002890)2.73451340
145ketone body metabolic process (GO:1902224)2.73390426
146regulation of interleukin-6 biosynthetic process (GO:0045408)2.71036998
147superoxide anion generation (GO:0042554)2.70447404
148detection of molecule of bacterial origin (GO:0032490)2.68717730
149detection of other organism (GO:0098543)2.68424574
150negative regulation of lymphocyte mediated immunity (GO:0002707)2.67218062
151desmosome organization (GO:0002934)2.64702409
152negative regulation of interleukin-1 production (GO:0032692)2.64423012
153NAD biosynthetic process (GO:0009435)2.64344771
154amine catabolic process (GO:0009310)2.63353722
155cellular biogenic amine catabolic process (GO:0042402)2.63353722
156negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.61511594
157neural tube formation (GO:0001841)2.58074467
158intestinal epithelial cell development (GO:0060576)2.57754262
159negative regulation of interleukin-1 beta production (GO:0032691)2.56763022
160negative regulation of T cell mediated immunity (GO:0002710)2.55871752
161negative regulation of adaptive immune response (GO:0002820)2.55283775
162phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55278696
163response to xenobiotic stimulus (GO:0009410)2.54965813
164aromatic amino acid family catabolic process (GO:0009074)2.53447295
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52513371
166detection of light stimulus involved in visual perception (GO:0050908)2.52430849
167detection of light stimulus involved in sensory perception (GO:0050962)2.52430849
168positive regulation of toll-like receptor signaling pathway (GO:0034123)2.52317721
169interferon-gamma secretion (GO:0072643)2.52220724
170cytidine deamination (GO:0009972)2.51478904
171cytidine metabolic process (GO:0046087)2.51478904
172cytidine catabolic process (GO:0006216)2.51478904
173dendritic cell migration (GO:0036336)2.50967139
174motile cilium assembly (GO:0044458)2.50701030
175detection of bacterium (GO:0016045)2.50603966
176regulation of MHC class I biosynthetic process (GO:0045343)2.50450224
177detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49171239
178neutrophil activation involved in immune response (GO:0002283)2.49146868
179positive regulation of defense response to virus by host (GO:0002230)2.48833103
180positive regulation of T cell mediated cytotoxicity (GO:0001916)2.48613817
181phosphatidylserine acyl-chain remodeling (GO:0036150)2.48025212
182detection of external biotic stimulus (GO:0098581)2.45333332
183keratinocyte proliferation (GO:0043616)2.44892421
184adaptation of signaling pathway (GO:0023058)2.44846561
185negative regulation of humoral immune response (GO:0002921)2.44555581
186neutrophil mediated immunity (GO:0002446)2.44010718
187positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43782466
188benzene-containing compound metabolic process (GO:0042537)2.42722664
189cellular extravasation (GO:0045123)2.41099850
190nicotinamide nucleotide biosynthetic process (GO:0019359)2.40865660
191pyridine nucleotide biosynthetic process (GO:0019363)2.40865660
192macrophage activation (GO:0042116)2.40393654
193purinergic nucleotide receptor signaling pathway (GO:0035590)2.39969017
194negative regulation of complement activation (GO:0045916)2.38671299
195positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.37877743
196antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.36825561
197water homeostasis (GO:0030104)2.35871254
198negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.33717954
199regulation of cilium movement (GO:0003352)2.33563304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.20640574
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.64438120
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.62229183
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.62229183
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.62229183
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.47992546
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.41070214
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.31746722
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17004248
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.94251418
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.90856729
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.80941088
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.74043447
14VDR_22108803_ChIP-Seq_LS180_Human2.72504838
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.55594545
16ZNF274_21170338_ChIP-Seq_K562_Hela2.47546702
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39881640
18* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.36220804
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26936901
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.26645190
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.22423653
22POU5F1_16518401_ChIP-PET_MESCs_Mouse2.22026457
23VDR_21846776_ChIP-Seq_THP-1_Human2.19195468
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.17588688
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.14311538
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.13937494
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.09793651
28STAT3_1855785_ChIP-Seq_MESCs_Mouse2.08349346
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.08208189
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07872919
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.99802045
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.95615270
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89426853
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88225936
35* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85975687
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85187912
37ER_23166858_ChIP-Seq_MCF-7_Human1.82236618
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76015373
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75107117
40* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73496118
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73286192
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72336624
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70646549
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.70067065
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.69914694
46* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69539315
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.66540216
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65294089
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62902652
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.62713333
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62697915
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.61229843
53MYC_22102868_ChIP-Seq_BL_Human1.60197599
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58381008
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58288452
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55142503
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55004551
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53458700
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53148956
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51217277
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.51217277
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51014407
63BCAT_22108803_ChIP-Seq_LS180_Human1.49941590
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47080254
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46600024
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46399156
67IGF1R_20145208_ChIP-Seq_DFB_Human1.45919098
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45328973
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.43445069
70TAF15_26573619_Chip-Seq_HEK293_Human1.42941581
71* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42736057
72GATA3_26560356_Chip-Seq_TH2_Human1.42625580
73ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40966649
74* P300_19829295_ChIP-Seq_ESCs_Human1.40591733
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40572088
76GBX2_23144817_ChIP-Seq_PC3_Human1.39914866
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.38865495
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38694174
79FUS_26573619_Chip-Seq_HEK293_Human1.38306923
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36978717
81PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.36801712
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35890857
83* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35841067
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35819102
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35273921
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.33607726
87* CDX2_22108803_ChIP-Seq_LS180_Human1.32156243
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31559398
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.31311705
90IRF1_19129219_ChIP-ChIP_H3396_Human1.31007258
91* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30408039
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29547198
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29547198
94AR_25329375_ChIP-Seq_VCAP_Human1.29503610
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29488411
96* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28984905
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28866393
98RACK7_27058665_Chip-Seq_MCF-7_Human1.28655292
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28042445
100TP63_23658742_ChIP-Seq_EP156T_Human1.27965481
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27738234
102CBP_20019798_ChIP-Seq_JUKART_Human1.27738234
103EWS_26573619_Chip-Seq_HEK293_Human1.27420372
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26900224
105AR_20517297_ChIP-Seq_VCAP_Human1.26780381
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26171501
107* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26132880
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25999631
109LXR_22292898_ChIP-Seq_THP-1_Human1.25831977
110AHR_22903824_ChIP-Seq_MCF-7_Human1.25674892
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24858159
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.24800383
113TCF4_22108803_ChIP-Seq_LS180_Human1.24371617
114SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24246621
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24140771
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23846226
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23640336
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.22578350
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.21795856
120* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21773283
121GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20355977
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20249383
123* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19852265
124CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19669614
125NANOG_19829295_ChIP-Seq_ESCs_Human1.19638849
126SOX2_19829295_ChIP-Seq_ESCs_Human1.19638849
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.19299538
128* STAT3_23295773_ChIP-Seq_U87_Human1.18764844
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18126733
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16834347
131NCOR_22424771_ChIP-Seq_293T_Human1.16831667
132GATA4_25053715_ChIP-Seq_YYC3_Human1.16591399
133NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15894483
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15805685
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15367626
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14679479
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13960651
138* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13441231
139* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13365958
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.13325823
141E2F1_21310950_ChIP-Seq_MCF-7_Human1.13184036
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12549933
143EGR1_19374776_ChIP-ChIP_THP-1_Human1.12459615
144PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12227831
145ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12225822
146NANOG_16518401_ChIP-PET_MESCs_Mouse1.10979708
147SMAD4_21799915_ChIP-Seq_A2780_Human1.10772957
148ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10624493
149HOXB7_26014856_ChIP-Seq_BT474_Human1.10420756
150STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10293162
151GATA1_22025678_ChIP-Seq_K562_Human1.10045391
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09945505
153TCF4_23295773_ChIP-Seq_U87_Human1.09469688
154AR_21572438_ChIP-Seq_LNCaP_Human1.09328542
155SMRT_27268052_Chip-Seq_Bcells_Human1.09247845
156ZNF263_19887448_ChIP-Seq_K562_Human1.09163077
157CDX2_20551321_ChIP-Seq_CACO-2_Human1.08080667
158OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07786406
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07185240
160GATA6_21074721_ChIP-Seq_CACO-2_Human1.07017282
161KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06676284
162KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06634949
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06066052
164SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05678553
165KAP1_27257070_Chip-Seq_ESCs_Mouse1.05646956
166ETV1_20927104_ChIP-Seq_GIST48_Human1.05637451
167SMAD4_21741376_ChIP-Seq_EPCs_Human1.05451045
168VDR_24787735_ChIP-Seq_THP-1_Human1.05331835
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05227402
170CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05217757
171GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05015157
172CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03708025
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03670341
174TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03428203
175KDM2B_26808549_Chip-Seq_DND41_Human1.03322368
176P53_22387025_ChIP-Seq_ESCs_Mouse1.02926709
177NANOG_18555785_Chip-Seq_ESCs_Mouse1.02680473
178RBPJ_21746931_ChIP-Seq_IB4_Human1.02230342
179TP63_19390658_ChIP-ChIP_HaCaT_Human1.01970241
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01742711
181KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01633796
182ELK3_25401928_ChIP-Seq_HUVEC_Human1.01234067
183CEBPB_22108803_ChIP-Seq_LS180_Human1.01198623
184TP53_22573176_ChIP-Seq_HFKS_Human1.01044313
185NOTCH1_21737748_ChIP-Seq_TLL_Human1.00938969
186* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00290448
187CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99982613
188KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99097399
189TP53_20018659_ChIP-ChIP_R1E_Mouse0.98726238
190ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98610006
191CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95680484
192KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93370661
193TFEB_21752829_ChIP-Seq_HELA_Human0.92546323
194TTF2_22483619_ChIP-Seq_HELA_Human0.92362988
195P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91615700
196TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90807327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.39355581
2MP0005171_absent_coat_pigmentation3.63527347
3MP0009278_abnormal_bone_marrow3.59987146
4MP0010030_abnormal_orbit_morphology3.47959509
5MP0003724_increased_susceptibility_to3.20228069
6MP0008875_abnormal_xenobiotic_pharmacok3.07725769
7MP0003195_calcinosis3.00830738
8MP0002009_preneoplasia2.99115433
9MP0002277_abnormal_respiratory_mucosa2.82212731
10MP0004381_abnormal_hair_follicle2.73893318
11MP0000383_abnormal_hair_follicle2.64583722
12MP0000427_abnormal_hair_cycle2.61856273
13MP0000569_abnormal_digit_pigmentation2.56711328
14MP0010678_abnormal_skin_adnexa2.49874197
15MP0010094_abnormal_chromosome_stability2.48285045
16MP0004233_abnormal_muscle_weight2.34176673
17MP0010352_gastrointestinal_tract_polyps2.28528928
18MP0003453_abnormal_keratinocyte_physiol2.21672085
19MP0004043_abnormal_pH_regulation2.12036868
20MP0005085_abnormal_gallbladder_physiolo2.11965900
21MP0008995_early_reproductive_senescence2.11498505
22MP0003941_abnormal_skin_development2.08464724
23MP0004133_heterotaxia2.07952997
24MP0003890_abnormal_embryonic-extraembry2.04331466
25MP0000490_abnormal_crypts_of2.01862735
26MP0005174_abnormal_tail_pigmentation2.01310432
27MP0005076_abnormal_cell_differentiation2.00699737
28MP0001545_abnormal_hematopoietic_system2.00166608
29MP0005397_hematopoietic_system_phenotyp2.00166608
30MP0010234_abnormal_vibrissa_follicle1.98420785
31MP0003786_premature_aging1.96144835
32MP0003878_abnormal_ear_physiology1.95088682
33MP0005377_hearing/vestibular/ear_phenot1.95088682
34MP0009785_altered_susceptibility_to1.91335746
35MP0004957_abnormal_blastocyst_morpholog1.89572642
36MP0002138_abnormal_hepatobiliary_system1.89272334
37MP0003011_delayed_dark_adaptation1.81861054
38MP0001835_abnormal_antigen_presentation1.78892252
39MP0008058_abnormal_DNA_repair1.75457462
40MP0002796_impaired_skin_barrier1.73181202
41MP0001800_abnormal_humoral_immune1.72488958
42MP0002249_abnormal_larynx_morphology1.72350152
43MP0003252_abnormal_bile_duct1.71611118
44MP0005671_abnormal_response_to1.71486825
45MP0001293_anophthalmia1.71469130
46MP0003119_abnormal_digestive_system1.68746799
47MP0002098_abnormal_vibrissa_morphology1.67244414
48MP0005387_immune_system_phenotype1.67123098
49MP0001790_abnormal_immune_system1.67123098
50MP0003111_abnormal_nucleus_morphology1.65251277
51MP0002086_abnormal_extraembryonic_tissu1.64852956
52MP0002084_abnormal_developmental_patter1.63182881
53MP0002282_abnormal_trachea_morphology1.61262214
54MP0009764_decreased_sensitivity_to1.61146604
55MP0003806_abnormal_nucleotide_metabolis1.61128448
56MP0004197_abnormal_fetal_growth/weight/1.59546392
57MP0008877_abnormal_DNA_methylation1.59013206
58MP0002148_abnormal_hypersensitivity_rea1.51728961
59MP0000579_abnormal_nail_morphology1.51196536
60MP0002095_abnormal_skin_pigmentation1.50187437
61MP0002876_abnormal_thyroid_physiology1.50045919
62MP0002928_abnormal_bile_duct1.48054756
63MP0001485_abnormal_pinna_reflex1.46987665
64MP0000470_abnormal_stomach_morphology1.45765868
65MP0003077_abnormal_cell_cycle1.44543009
66MP0003566_abnormal_cell_adhesion1.43703403
67MP0001697_abnormal_embryo_size1.43128779
68MP0002085_abnormal_embryonic_tissue1.42520358
69MP0005365_abnormal_bile_salt1.42014736
70MP0005501_abnormal_skin_physiology1.41266558
71MP0008932_abnormal_embryonic_tissue1.40854343
72MP0005025_abnormal_response_to1.40788308
73MP0003567_abnormal_fetal_cardiomyocyte1.40139018
74MP0008872_abnormal_physiological_respon1.38116985
75MP0002653_abnormal_ependyma_morphology1.35796056
76MP0000015_abnormal_ear_pigmentation1.32810776
77MP0002723_abnormal_immune_serum1.32257750
78MP0001672_abnormal_embryogenesis/_devel1.30306334
79MP0005380_embryogenesis_phenotype1.30306334
80MP0002452_abnormal_antigen_presenting1.29810770
81MP0000350_abnormal_cell_proliferation1.29500857
82MP0000685_abnormal_immune_system1.29395428
83MP0002419_abnormal_innate_immunity1.29372779
84MP0006072_abnormal_retinal_apoptosis1.29348751
85MP0005075_abnormal_melanosome_morpholog1.29185909
86MP0004883_abnormal_blood_vessel1.29021210
87MP0004019_abnormal_vitamin_homeostasis1.25154860
88MP0002060_abnormal_skin_morphology1.24435405
89MP0000516_abnormal_urinary_system1.23445559
90MP0005367_renal/urinary_system_phenotyp1.23445559
91MP0004885_abnormal_endolymph1.22736706
92MP0010307_abnormal_tumor_latency1.21665733
93MP0002132_abnormal_respiratory_system1.21587073
94MP0005310_abnormal_salivary_gland1.21092356
95MP0002139_abnormal_hepatobiliary_system1.20913146
96MP0005551_abnormal_eye_electrophysiolog1.20724408
97MP0001873_stomach_inflammation1.20001900
98MP0002111_abnormal_tail_morphology1.19830577
99MP0003045_fibrosis1.19714457
100MP0003436_decreased_susceptibility_to1.19141323
101MP0000762_abnormal_tongue_morphology1.18987830
102MP0000371_diluted_coat_color1.18628108
103MP0006082_CNS_inflammation1.15858987
104MP0003283_abnormal_digestive_organ1.15231192
105MP0001986_abnormal_taste_sensitivity1.14099965
106MP0001919_abnormal_reproductive_system1.13462023
107MP0003183_abnormal_peptide_metabolism1.13395952
108MP0005000_abnormal_immune_tolerance1.11463852
109MP0003693_abnormal_embryo_hatching1.11425396
110MP0000432_abnormal_head_morphology1.09831070
111MP0005623_abnormal_meninges_morphology1.09658751
112MP0003172_abnormal_lysosome_physiology1.07712823
113MP0003638_abnormal_response/metabolism_1.07203955
114MP0001819_abnormal_immune_cell1.06129351
115MP0001340_abnormal_eyelid_morphology1.05572610
116MP0002420_abnormal_adaptive_immunity1.04997169
117MP0003136_yellow_coat_color1.03591898
118MP0001845_abnormal_inflammatory_respons1.03573917
119MP0001501_abnormal_sleep_pattern1.03180564
120MP0003984_embryonic_growth_retardation1.02594325
121MP0002019_abnormal_tumor_incidence1.02585451
122MP0003755_abnormal_palate_morphology1.02080517
123MP0002837_dystrophic_cardiac_calcinosis1.02078855
124MP0004264_abnormal_extraembryonic_tissu1.01725095
125MP0002405_respiratory_system_inflammati1.01419005
126MP0001765_abnormal_ion_homeostasis1.00995290
127MP0003828_pulmonary_edema1.00921436
128MP0001216_abnormal_epidermal_layer0.99729364
129MP0005084_abnormal_gallbladder_morpholo0.99680726
130MP0000372_irregular_coat_pigmentation0.99589470
131MP0002088_abnormal_embryonic_growth/wei0.98602808
132MP0000377_abnormal_hair_follicle0.98492624
133MP0000647_abnormal_sebaceous_gland0.97676644
134MP0004142_abnormal_muscle_tone0.97663727
135MP0002693_abnormal_pancreas_physiology0.95385187
136MP0001730_embryonic_growth_arrest0.95335707
137MP0005408_hypopigmentation0.95288876
138MP0005164_abnormal_response_to0.94674872
139MP0005023_abnormal_wound_healing0.93366812
140MP0000467_abnormal_esophagus_morphology0.92947303
141MP0005389_reproductive_system_phenotype0.92171367
142MP0003935_abnormal_craniofacial_develop0.91551437
143MP0002080_prenatal_lethality0.90627644
144MP0000462_abnormal_digestive_system0.90152362
145MP0003936_abnormal_reproductive_system0.89948465
146MP0008469_abnormal_protein_level0.89385766
147MP0005508_abnormal_skeleton_morphology0.89372516
148MP0002396_abnormal_hematopoietic_system0.88477271
149MP0002075_abnormal_coat/hair_pigmentati0.87773949
150MP0005360_urolithiasis0.87402835
151MP0008007_abnormal_cellular_replicative0.86311724
152MP0002932_abnormal_joint_morphology0.86263883
153MP0002909_abnormal_adrenal_gland0.86233509
154MP0009053_abnormal_anal_canal0.86181597
155MP0002114_abnormal_axial_skeleton0.85372803
156MP0000477_abnormal_intestine_morphology0.85178759
157MP0008961_abnormal_basal_metabolism0.85113537
158MP0009643_abnormal_urine_homeostasis0.84873254
159MP0003646_muscle_fatigue0.83471883
160MP0004947_skin_inflammation0.83423142
161MP0003866_abnormal_defecation0.83301526
162MP0002166_altered_tumor_susceptibility0.82748387
163MP0002006_tumorigenesis0.82109559
164MP0002102_abnormal_ear_morphology0.80799966
165MP0002116_abnormal_craniofacial_bone0.80611582
166MP0009379_abnormal_foot_pigmentation0.80538333
167MP0010155_abnormal_intestine_physiology0.79326716
168MP0001324_abnormal_eye_pigmentation0.77840963
169MP0001533_abnormal_skeleton_physiology0.77784978
170MP0005645_abnormal_hypothalamus_physiol0.76660684
171MP0000313_abnormal_cell_death0.76502283
172MP0001186_pigmentation_phenotype0.76209175
173MP0000627_abnormal_mammary_gland0.76106940
174MP0004782_abnormal_surfactant_physiolog0.75630398
175MP0002697_abnormal_eye_size0.75625163
176MP0001348_abnormal_lacrimal_gland0.75328413
177MP0009333_abnormal_splenocyte_physiolog0.75175738
178MP0003718_maternal_effect0.74296681
179MP0003385_abnormal_body_wall0.73280221
180MP0005058_abnormal_lysosome_morphology0.72974879
181MP0005248_abnormal_Harderian_gland0.71422231
182MP0003763_abnormal_thymus_physiology0.70716476

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.94507791
2Alopecia of scalp (HP:0002293)4.69575068
3Concave nail (HP:0001598)4.55070257
4Pustule (HP:0200039)4.50394271
5Annular pancreas (HP:0001734)4.34721049
6Increased IgM level (HP:0003496)4.32261317
7Rectovaginal fistula (HP:0000143)4.22777383
8Rectal fistula (HP:0100590)4.22777383
9Facial hemangioma (HP:0000329)4.14331895
10Absent/shortened dynein arms (HP:0200106)4.13720918
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.13720918
12Pancreatic cysts (HP:0001737)4.13297914
13Poikiloderma (HP:0001029)4.08949243
14Abnormal ciliary motility (HP:0012262)4.06408371
15Intestinal fistula (HP:0100819)3.86225345
16Abnormal respiratory motile cilium physiology (HP:0012261)3.83823307
17Ulnar bowing (HP:0003031)3.72773942
18Short humerus (HP:0005792)3.71909966
19Vaginal fistula (HP:0004320)3.70498835
20True hermaphroditism (HP:0010459)3.69831126
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65898466
22Intestinal atresia (HP:0011100)3.60502744
23Coronal craniosynostosis (HP:0004440)3.54856485
24Aplasia/hypoplasia of the humerus (HP:0006507)3.53020871
25Pancreatic fibrosis (HP:0100732)3.45156608
26Hypochromic microcytic anemia (HP:0004840)3.43487766
27Absent radius (HP:0003974)3.31420406
28Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.25862916
29Vertebral hypoplasia (HP:0008417)3.25862916
30Abnormal hemoglobin (HP:0011902)3.20965185
31Aplasia involving forearm bones (HP:0009822)3.20353522
32Absent forearm bone (HP:0003953)3.20353522
33Turricephaly (HP:0000262)3.18480811
34Congenital stationary night blindness (HP:0007642)3.12887655
35Furrowed tongue (HP:0000221)3.10870375
36Congenital, generalized hypertrichosis (HP:0004540)3.10836738
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.10457760
38Tongue fasciculations (HP:0001308)3.10061327
39Rhinitis (HP:0012384)3.10031729
40Selective tooth agenesis (HP:0001592)3.02049686
41Squamous cell carcinoma (HP:0002860)2.99863614
42Absent thumb (HP:0009777)2.98314230
43Abnormality of secondary sexual hair (HP:0009888)2.96941301
44Abnormality of the axillary hair (HP:0100134)2.96941301
45Molar tooth sign on MRI (HP:0002419)2.90925569
46Abnormality of midbrain morphology (HP:0002418)2.90925569
47Nephronophthisis (HP:0000090)2.86123478
48Bronchiectasis (HP:0002110)2.83012812
49Abnormality of male internal genitalia (HP:0000022)2.81801041
50Muscle fibrillation (HP:0010546)2.80404993
51Basal cell carcinoma (HP:0002671)2.79993787
52Chronic sinusitis (HP:0011109)2.79753187
53Orthostatic hypotension (HP:0001278)2.79132811
54Volvulus (HP:0002580)2.77545006
55Abnormality of the renal medulla (HP:0100957)2.76363837
56Tubular atrophy (HP:0000092)2.75469213
57Alacrima (HP:0000522)2.74342838
58Albinism (HP:0001022)2.72327988
59Optic neuritis (HP:0100653)2.71423944
60Retrobulbar optic neuritis (HP:0100654)2.71423944
61Hypochromic anemia (HP:0001931)2.69357111
62Aplasia of the musculature (HP:0100854)2.69308612
63Abnormality of nail color (HP:0100643)2.68793264
64Abnormality of the renal cortex (HP:0011035)2.67125795
65Woolly hair (HP:0002224)2.65871849
66Hypotrichosis (HP:0001006)2.65084161
67Large for gestational age (HP:0001520)2.64876269
68Gastrointestinal atresia (HP:0002589)2.63591088
69Short chin (HP:0000331)2.62867998
70Abnormality of the nasal septum (HP:0000419)2.62094958
71Stomach cancer (HP:0012126)2.61792429
72Plantar hyperkeratosis (HP:0007556)2.59982177
73Popliteal pterygium (HP:0009756)2.58916726
74IgA deficiency (HP:0002720)2.58082747
75Stomatitis (HP:0010280)2.57914793
76Recurrent bacterial skin infections (HP:0005406)2.57765662
77Cystic liver disease (HP:0006706)2.57284370
78Increased number of teeth (HP:0011069)2.55731413
79Bifid uvula (HP:0000193)2.54046874
80Congenital hip dislocation (HP:0001374)2.53694531
81Chronic bronchitis (HP:0004469)2.53509377
82Orchitis (HP:0100796)2.51866693
83Broad alveolar ridges (HP:0000187)2.48910207
84Bowing of the arm (HP:0006488)2.44578606
85Bowed forearm bones (HP:0003956)2.44578606
86Hypotelorism (HP:0000601)2.43866155
87Male infertility (HP:0003251)2.43351951
88Myositis (HP:0100614)2.41569160
89Parakeratosis (HP:0001036)2.41420767
90Anteriorly placed anus (HP:0001545)2.39873828
91Patellar aplasia (HP:0006443)2.38596872
92Abnormal rod and cone electroretinograms (HP:0008323)2.38070655
93Acute lymphatic leukemia (HP:0006721)2.37849731
94Decreased circulating renin level (HP:0003351)2.37344608
95Premature graying of hair (HP:0002216)2.36868932
96Cheilitis (HP:0100825)2.33299259
97Astrocytoma (HP:0009592)2.33147284
98Abnormality of the astrocytes (HP:0100707)2.33147284
99Vertebral fusion (HP:0002948)2.31573374
100Elevated erythrocyte sedimentation rate (HP:0003565)2.30341702
101Keratoconjunctivitis (HP:0001096)2.28105702
102Premature skin wrinkling (HP:0100678)2.27287854
103Urinary glycosaminoglycan excretion (HP:0003541)2.24905081
104Mucopolysacchariduria (HP:0008155)2.24905081
105Neoplasm of the oral cavity (HP:0100649)2.21573341
106Hamartoma (HP:0010566)2.21062885
107Medial flaring of the eyebrow (HP:0010747)2.20793015
108Esophageal atresia (HP:0002032)2.20328793
109Muscle fiber atrophy (HP:0100295)2.20307704
110Chronic otitis media (HP:0000389)2.18101261
111Abnormality of the labia minora (HP:0012880)2.17835745
112Hemivertebrae (HP:0002937)2.17138278
113Decreased lacrimation (HP:0000633)2.16131821
114Keratoconjunctivitis sicca (HP:0001097)2.14911132
115Duplicated collecting system (HP:0000081)2.14575017
116Increased IgE level (HP:0003212)2.14216676
117Gangrene (HP:0100758)2.14018469
118Amelogenesis imperfecta (HP:0000705)2.13905711
119Eczematoid dermatitis (HP:0000976)2.12960191
120Aplasia/Hypoplasia of the patella (HP:0006498)2.12938645
121Shawl scrotum (HP:0000049)2.12743891
122Polydipsia (HP:0001959)2.10862182
123Abnormal drinking behavior (HP:0030082)2.10862182
124Type 2 muscle fiber atrophy (HP:0003554)2.10304623
125Lip pit (HP:0100267)2.07975479
126Chronic hepatic failure (HP:0100626)2.07233258
127Spinal muscular atrophy (HP:0007269)2.07168958
128Recurrent skin infections (HP:0001581)2.05994265
129Abnormality of the aortic arch (HP:0012303)2.05774039
130Bronchitis (HP:0012387)2.05254884
131Type II lissencephaly (HP:0007260)2.04768728
132Dysautonomia (HP:0002459)2.04474925
133Cerebral aneurysm (HP:0004944)2.03950117
134Abnormality of the renal collecting system (HP:0004742)2.02758034
135Abnormality of polysaccharide metabolism (HP:0011012)2.02689821
136Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02689821
137Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02689821
138Congenital hepatic fibrosis (HP:0002612)2.02029106
139Fair hair (HP:0002286)2.01951671
140Abnormal delayed hypersensitivity skin test (HP:0002963)2.00552749
141Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00447293
142Chronic mucocutaneous candidiasis (HP:0002728)2.00043071
143Recurrent cutaneous fungal infections (HP:0011370)2.00043071
144Median cleft lip (HP:0000161)2.00039795
145Decreased central vision (HP:0007663)2.00031611
146Split hand (HP:0001171)1.99889876
147Hypoplastic labia majora (HP:0000059)1.99506125
148Abnormal number of incisors (HP:0011064)1.99315048
149Dysostosis multiplex (HP:0000943)1.98593786
150Thick nail (HP:0001805)1.98524977
151Onycholysis (HP:0001806)1.98378710
152Abnormal biliary tract physiology (HP:0012439)1.97033013
153Bile duct proliferation (HP:0001408)1.97033013
154Joint stiffness (HP:0001387)1.96689171
155Clumsiness (HP:0002312)1.96438177
156Abnormal respiratory epithelium morphology (HP:0012253)1.95765529
157Abnormal respiratory motile cilium morphology (HP:0005938)1.95765529
158Recurrent abscess formation (HP:0002722)1.95585065
159Hyperventilation (HP:0002883)1.94895619
160Capillary hemangiomas (HP:0005306)1.93319162
161Bilateral sensorineural hearing impairment (HP:0008619)1.93071818
162Male pseudohermaphroditism (HP:0000037)1.92803369
163Hypoplasia of the radius (HP:0002984)1.92268971
164Erythroderma (HP:0001019)1.92126032
165Recurrent sinusitis (HP:0011108)1.91747844
166Pili torti (HP:0003777)1.91279626
167Nail dystrophy (HP:0008404)1.91020470
168Conjunctival hamartoma (HP:0100780)1.90142174
169Generalized amyotrophy (HP:0003700)1.89215897
170Choanal stenosis (HP:0000452)1.88904245
171Widely spaced teeth (HP:0000687)1.88171438
172Pruritus (HP:0000989)1.88044905
173Palmar hyperkeratosis (HP:0010765)1.86840155
174Palmoplantar hyperkeratosis (HP:0000972)1.86713565
175Abnormal hair laboratory examination (HP:0003328)1.86064479
176Attenuation of retinal blood vessels (HP:0007843)1.84092906
177Generalized hypopigmentation of hair (HP:0011358)1.83039332
178Abolished electroretinogram (ERG) (HP:0000550)1.82822604
179Congenital ichthyosiform erythroderma (HP:0007431)1.82601909
180Abnormality of macrophages (HP:0004311)1.79709773
181Hyperactive renin-angiotensin system (HP:0000841)1.77435106
182Anencephaly (HP:0002323)1.75398862
183Nasal polyposis (HP:0100582)1.74856201
184Recurrent fungal infections (HP:0002841)1.74276154
185Recurrent gram-negative bacterial infections (HP:0005420)1.74247166
186Sclerocornea (HP:0000647)1.74079367
187Macular degeneration (HP:0000608)1.73588361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.79091098
2ICK5.35144555
3DDR24.87973725
4MAPK154.23455028
5MAP3K64.04496827
6EPHA23.35560590
7MAP3K113.25872832
8MATK2.84909296
9FGR2.82060887
10ACVR1B2.80900032
11PIM22.74875413
12TYRO32.63812817
13PINK12.62557847
14ADRBK22.49523890
15IRAK42.29700391
16BMX2.24300543
17TRPM72.23810889
18YES12.09650106
19CSK2.09372616
20PRKD22.09256015
21OXSR12.06748660
22GRK12.04303319
23ZAK2.01770673
24PDGFRA1.96722638
25BMPR1B1.95106757
26TAOK31.94273816
27CDK71.94200740
28DYRK1B1.93117049
29DAPK11.89073540
30IRAK11.82088534
31MAP3K21.75243547
32CDK61.74883903
33INSRR1.74304568
34PIM11.73810440
35UHMK11.67763822
36STK391.57629806
37MAP2K61.57073373
38CDK121.53653584
39RPS6KB21.52658931
40WNK31.47873732
41BLK1.46183943
42BRSK21.41018505
43TLK11.39064813
44TGFBR11.35767885
45WNK41.35329635
46AKT31.32873696
47IKBKE1.27662697
48PAK31.27419154
49RIPK41.27068026
50CASK1.24436026
51NUAK11.23235981
52TYK21.23080047
53STK241.22224725
54GRK61.21559928
55TRIM281.20305949
56ADRBK11.19421362
57FER1.18191805
58RPS6KL11.17136651
59RPS6KC11.17136651
60KIT1.16957977
61LATS21.15998266
62MAP4K21.13512729
63DAPK21.12562200
64CHEK21.09096249
65PTK2B1.08965924
66GSK3A1.04104092
67PNCK1.02804806
68RPS6KA61.02803637
69LATS10.94073697
70MST1R0.93969552
71CDC42BPA0.91491308
72PLK10.91468718
73EPHB10.90686693
74MAPK110.90256196
75CAMKK20.90106820
76EPHA30.88237302
77PRPF4B0.87695074
78TAOK20.86876181
79NME10.84808045
80PIK3CA0.84806169
81NLK0.82736988
82MTOR0.81731462
83CDC70.80500319
84PIK3CG0.80413260
85MAP3K30.76287061
86TEC0.75391658
87JAK30.73882005
88MST40.73179342
89FLT30.72920938
90DYRK30.72871932
91JAK20.72449636
92ATR0.72229189
93RPS6KA10.70448571
94MAP2K40.70271821
95BMPR20.68754246
96STK110.68721933
97BTK0.68549784
98PRKCE0.67431215
99SYK0.67245098
100STK30.64578574
101CSF1R0.64493106
102ERBB30.63415974
103EEF2K0.62973215
104STK100.62280254
105IRAK20.62217081
106PRKCI0.61249737
107TAF10.60938674
108MAPK130.60707692
109MKNK20.60532118
110HCK0.59812524
111STK380.59565005
112PRKCQ0.56919111
113ITK0.55468914
114MAPKAPK30.54274732
115PRKAA20.54260862
116PDGFRB0.53939909
117HIPK20.53370258
118CHUK0.52229230
119GRK70.52205650
120BCR0.51665501
121FGFR10.51473084
122ZAP700.50754709
123CDK20.50482267
124MAP4K10.49920130
125MAPKAPK20.49862448
126TBK10.49515262
127RPS6KB10.49480326
128EGFR0.49314653
129AURKB0.49193055
130MAP3K100.48217927
131JAK10.48011844
132PHKG10.47205310
133PHKG20.47205310
134MAP3K140.46665895
135CHEK10.45995849
136IKBKB0.45089015
137LYN0.45014608
138MKNK10.43934280
139ATM0.43533308
140ERBB20.42723073
141MAPK10.42472468
142MAP3K120.42278499
143PRKCZ0.42114075
144CSNK2A10.41632363
145PAK40.40232809
146PTK20.39840330
147PAK20.38718774
148WEE10.38594930
149ALK0.38101635
150PRKAA10.37352719
151NEK20.37232210
152WNK10.37082339
153MAPK30.37005856
154MUSK0.35797762
155MAPK140.34856283
156INSR0.32766235
157CSNK2A20.32678701
158CDK40.32194027
159AURKA0.31551427
160CDK80.30275564
161STK40.29635724
162RPS6KA40.29538603
163ABL10.27816856
164CDK10.26630254
165MAPK100.25834324
166LCK0.25532016
167SIK10.25324557
168TXK0.24852339
169TNK20.24836693
170MAP2K30.24111053
171RIPK10.23943189
172AKT10.22492997
173AKT20.22364906
174STK38L0.20884628

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.56912429
2Fatty acid biosynthesis_Homo sapiens_hsa000614.19014065
3Base excision repair_Homo sapiens_hsa034103.88616995
4DNA replication_Homo sapiens_hsa030303.45071474
5Caffeine metabolism_Homo sapiens_hsa002323.34641638
6Linoleic acid metabolism_Homo sapiens_hsa005913.18832844
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.72327708
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33564797
9p53 signaling pathway_Homo sapiens_hsa041152.33186106
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31952430
11Chemical carcinogenesis_Homo sapiens_hsa052042.27746144
12Nitrogen metabolism_Homo sapiens_hsa009102.23074390
13Nucleotide excision repair_Homo sapiens_hsa034202.20670998
14Histidine metabolism_Homo sapiens_hsa003402.19706070
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.19336805
16Homologous recombination_Homo sapiens_hsa034402.04005573
17Staphylococcus aureus infection_Homo sapiens_hsa051502.03763480
18Fanconi anemia pathway_Homo sapiens_hsa034602.03550480
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99988509
20Hippo signaling pathway_Homo sapiens_hsa043901.98129971
21Phototransduction_Homo sapiens_hsa047441.98128981
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97171682
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94931236
24Tryptophan metabolism_Homo sapiens_hsa003801.94429200
25Adherens junction_Homo sapiens_hsa045201.93685396
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.92664879
27RNA transport_Homo sapiens_hsa030131.92618751
28Spliceosome_Homo sapiens_hsa030401.89672789
29Retinol metabolism_Homo sapiens_hsa008301.89002803
30Hedgehog signaling pathway_Homo sapiens_hsa043401.87523097
31Notch signaling pathway_Homo sapiens_hsa043301.82207059
32Ether lipid metabolism_Homo sapiens_hsa005651.79365936
33mRNA surveillance pathway_Homo sapiens_hsa030151.75881159
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.74289941
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.73891493
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.68810856
37Arachidonic acid metabolism_Homo sapiens_hsa005901.65610926
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64890776
39mTOR signaling pathway_Homo sapiens_hsa041501.64088923
40Cell cycle_Homo sapiens_hsa041101.62002648
41TGF-beta signaling pathway_Homo sapiens_hsa043501.58762305
42Butanoate metabolism_Homo sapiens_hsa006501.56288027
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54073600
44Circadian rhythm_Homo sapiens_hsa047101.48498058
45Shigellosis_Homo sapiens_hsa051311.45382049
46Basal cell carcinoma_Homo sapiens_hsa052171.43906432
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40418541
48Bladder cancer_Homo sapiens_hsa052191.37781973
49ABC transporters_Homo sapiens_hsa020101.36452909
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36205087
51MicroRNAs in cancer_Homo sapiens_hsa052061.33828704
52Leishmaniasis_Homo sapiens_hsa051401.32119786
53Type I diabetes mellitus_Homo sapiens_hsa049401.31541696
54Small cell lung cancer_Homo sapiens_hsa052221.29379592
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24288881
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24174536
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21767617
58Wnt signaling pathway_Homo sapiens_hsa043101.21372719
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21188641
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18960066
61Primary immunodeficiency_Homo sapiens_hsa053401.14897820
62Arginine and proline metabolism_Homo sapiens_hsa003301.11838374
63Mineral absorption_Homo sapiens_hsa049781.11410899
64Drug metabolism - other enzymes_Homo sapiens_hsa009831.10970671
65Viral myocarditis_Homo sapiens_hsa054161.07363825
66Oxidative phosphorylation_Homo sapiens_hsa001901.05855396
67Sphingolipid metabolism_Homo sapiens_hsa006001.00519319
68Ribosome_Homo sapiens_hsa030100.99115971
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98065530
70Colorectal cancer_Homo sapiens_hsa052100.96663840
71Tuberculosis_Homo sapiens_hsa051520.96484585
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96223498
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94764083
74Chronic myeloid leukemia_Homo sapiens_hsa052200.94149108
75Viral carcinogenesis_Homo sapiens_hsa052030.92679764
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.92228747
77One carbon pool by folate_Homo sapiens_hsa006700.92127635
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91927561
79Tight junction_Homo sapiens_hsa045300.91046163
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90510276
81VEGF signaling pathway_Homo sapiens_hsa043700.87309310
82Peroxisome_Homo sapiens_hsa041460.85957244
83Fatty acid degradation_Homo sapiens_hsa000710.85734962
84Vitamin digestion and absorption_Homo sapiens_hsa049770.84456800
85Collecting duct acid secretion_Homo sapiens_hsa049660.82413079
86beta-Alanine metabolism_Homo sapiens_hsa004100.82203283
87Legionellosis_Homo sapiens_hsa051340.82079358
88Allograft rejection_Homo sapiens_hsa053300.81984525
89Ovarian steroidogenesis_Homo sapiens_hsa049130.81003901
90Proteoglycans in cancer_Homo sapiens_hsa052050.80398503
91African trypanosomiasis_Homo sapiens_hsa051430.80135481
92Acute myeloid leukemia_Homo sapiens_hsa052210.79725593
93Osteoclast differentiation_Homo sapiens_hsa043800.77582709
94Herpes simplex infection_Homo sapiens_hsa051680.76661429
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76534171
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75514757
97RNA degradation_Homo sapiens_hsa030180.75350097
98HTLV-I infection_Homo sapiens_hsa051660.74023316
99Lysine degradation_Homo sapiens_hsa003100.73216301
100Tyrosine metabolism_Homo sapiens_hsa003500.72390354
101Antigen processing and presentation_Homo sapiens_hsa046120.72204712
102Measles_Homo sapiens_hsa051620.71219876
103Complement and coagulation cascades_Homo sapiens_hsa046100.70974920
104Serotonergic synapse_Homo sapiens_hsa047260.69928980
105Thyroid cancer_Homo sapiens_hsa052160.68152860
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67234113
107Regulation of autophagy_Homo sapiens_hsa041400.66144418
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65671587
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65580132
110Glycerolipid metabolism_Homo sapiens_hsa005610.65175452
111Fat digestion and absorption_Homo sapiens_hsa049750.64580372
112Protein export_Homo sapiens_hsa030600.64314565
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63983177
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63351788
115Sulfur metabolism_Homo sapiens_hsa009200.62883798
116Hepatitis B_Homo sapiens_hsa051610.62858829
117Epstein-Barr virus infection_Homo sapiens_hsa051690.61848929
118Phenylalanine metabolism_Homo sapiens_hsa003600.60218708
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60136496
120Pathways in cancer_Homo sapiens_hsa052000.60039558
121Focal adhesion_Homo sapiens_hsa045100.59231127
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58748760
123Dorso-ventral axis formation_Homo sapiens_hsa043200.58714408
124Starch and sucrose metabolism_Homo sapiens_hsa005000.58609911
125ErbB signaling pathway_Homo sapiens_hsa040120.57967479
126Folate biosynthesis_Homo sapiens_hsa007900.57907149
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.57904880
128Biosynthesis of amino acids_Homo sapiens_hsa012300.57702497
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56529473
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56454213
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.54917287
132Rheumatoid arthritis_Homo sapiens_hsa053230.54709142
133Selenocompound metabolism_Homo sapiens_hsa004500.53025954
134Influenza A_Homo sapiens_hsa051640.52861547
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52801463
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52798459
137Apoptosis_Homo sapiens_hsa042100.52664943
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.52341431
139Oocyte meiosis_Homo sapiens_hsa041140.52235854
140Chemokine signaling pathway_Homo sapiens_hsa040620.51691789
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50478882
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49827319
143NF-kappa B signaling pathway_Homo sapiens_hsa040640.49785798
144Prostate cancer_Homo sapiens_hsa052150.49673418
145Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48243775
146Huntingtons disease_Homo sapiens_hsa050160.48055478
147Hematopoietic cell lineage_Homo sapiens_hsa046400.47958412
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.47788059
149Toxoplasmosis_Homo sapiens_hsa051450.47463106
150Pancreatic cancer_Homo sapiens_hsa052120.47211414
151Basal transcription factors_Homo sapiens_hsa030220.46980938
152Hepatitis C_Homo sapiens_hsa051600.46555844
153Non-homologous end-joining_Homo sapiens_hsa034500.46282527
154RNA polymerase_Homo sapiens_hsa030200.46127398
155Melanoma_Homo sapiens_hsa052180.45046794
156Taste transduction_Homo sapiens_hsa047420.44871581
157Olfactory transduction_Homo sapiens_hsa047400.44025102
158Autoimmune thyroid disease_Homo sapiens_hsa053200.43452165
159Pancreatic secretion_Homo sapiens_hsa049720.42849807
160Parkinsons disease_Homo sapiens_hsa050120.41834015
161RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41765982
162Choline metabolism in cancer_Homo sapiens_hsa052310.41233417
163Bile secretion_Homo sapiens_hsa049760.40909732
164Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40875749
165Endometrial cancer_Homo sapiens_hsa052130.40566905
166TNF signaling pathway_Homo sapiens_hsa046680.39841155
167MAPK signaling pathway_Homo sapiens_hsa040100.39374210
168ECM-receptor interaction_Homo sapiens_hsa045120.38647107
169Sulfur relay system_Homo sapiens_hsa041220.38341044
170Fructose and mannose metabolism_Homo sapiens_hsa000510.38086120
171Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37612982
172Graft-versus-host disease_Homo sapiens_hsa053320.36687675
173Salmonella infection_Homo sapiens_hsa051320.35204351
174Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35192612
175HIF-1 signaling pathway_Homo sapiens_hsa040660.33165778
176Pyrimidine metabolism_Homo sapiens_hsa002400.32631022
177Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31523069
178Asthma_Homo sapiens_hsa053100.30228487
179Central carbon metabolism in cancer_Homo sapiens_hsa052300.29984406
180B cell receptor signaling pathway_Homo sapiens_hsa046620.29776232

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