PRRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.92344149
2synaptic vesicle maturation (GO:0016188)5.90704961
3locomotory exploration behavior (GO:0035641)5.84492193
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.69740547
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.49333616
6vocalization behavior (GO:0071625)5.42779961
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35498657
8synaptic vesicle exocytosis (GO:0016079)5.22304807
9glutamate secretion (GO:0014047)5.07427924
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.95235812
11regulation of glutamate receptor signaling pathway (GO:1900449)4.89461115
12regulation of synaptic vesicle exocytosis (GO:2000300)4.85104602
13neuronal action potential propagation (GO:0019227)4.72609980
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.61302773
15protein localization to synapse (GO:0035418)4.57536098
16synaptic transmission, glutamatergic (GO:0035249)4.51242719
17regulation of neuronal synaptic plasticity (GO:0048168)4.49432099
18glutamate receptor signaling pathway (GO:0007215)4.44824149
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37485422
20exploration behavior (GO:0035640)4.34147405
21regulation of synaptic vesicle transport (GO:1902803)4.34040058
22neurotransmitter secretion (GO:0007269)4.31050002
23neuron cell-cell adhesion (GO:0007158)4.28114935
24potassium ion homeostasis (GO:0055075)4.24921791
25dendritic spine morphogenesis (GO:0060997)4.16190045
26long-term memory (GO:0007616)4.15638175
27neuron-neuron synaptic transmission (GO:0007270)4.13755253
28central nervous system myelination (GO:0022010)4.11695855
29axon ensheathment in central nervous system (GO:0032291)4.11695855
30regulation of synapse maturation (GO:0090128)4.08706869
31cellular potassium ion homeostasis (GO:0030007)4.08237267
32amino acid import (GO:0043090)4.08174052
33positive regulation of dendritic spine morphogenesis (GO:0061003)4.07752557
34gamma-aminobutyric acid transport (GO:0015812)4.05619854
35regulation of synapse structural plasticity (GO:0051823)4.02797602
36neurotransmitter-gated ion channel clustering (GO:0072578)4.00319740
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94359425
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93596564
39positive regulation of membrane potential (GO:0045838)3.92614163
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85553656
41layer formation in cerebral cortex (GO:0021819)3.84186047
42cellular sodium ion homeostasis (GO:0006883)3.81342201
43transmission of nerve impulse (GO:0019226)3.80990140
44regulation of postsynaptic membrane potential (GO:0060078)3.69095544
45regulation of dendritic spine morphogenesis (GO:0061001)3.68143014
46regulation of synaptic plasticity (GO:0048167)3.66558163
47sodium ion export (GO:0071436)3.66382954
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58975778
49cerebellar Purkinje cell differentiation (GO:0021702)3.58374767
50cerebellar granule cell differentiation (GO:0021707)3.56516144
51positive regulation of synapse maturation (GO:0090129)3.55407501
52neurotransmitter transport (GO:0006836)3.55307096
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.53010878
54negative regulation of dendrite morphogenesis (GO:0050774)3.52445572
55synaptic vesicle endocytosis (GO:0048488)3.51685786
56neuromuscular process controlling balance (GO:0050885)3.47863923
57long-term synaptic potentiation (GO:0060291)3.46714976
58L-amino acid import (GO:0043092)3.44773111
59neuromuscular process controlling posture (GO:0050884)3.41965629
60cerebellar Purkinje cell layer development (GO:0021680)3.41757143
61regulation of neurotransmitter secretion (GO:0046928)3.39874164
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39650806
63neuron recognition (GO:0008038)3.37836175
64neuronal ion channel clustering (GO:0045161)3.37369219
65auditory behavior (GO:0031223)3.34068429
66acidic amino acid transport (GO:0015800)3.33830408
67regulation of vesicle fusion (GO:0031338)3.33412593
68glycine transport (GO:0015816)3.33059279
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.32385472
70regulation of neurotransmitter levels (GO:0001505)3.31754374
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.27143404
72adult walking behavior (GO:0007628)3.24692209
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23177122
74membrane depolarization (GO:0051899)3.23103643
75neuromuscular synaptic transmission (GO:0007274)3.22661752
76dendrite morphogenesis (GO:0048813)3.21079098
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20480640
78presynaptic membrane organization (GO:0097090)3.20107429
79presynaptic membrane assembly (GO:0097105)3.19779723
80dendritic spine organization (GO:0097061)3.19392236
81postsynaptic membrane organization (GO:0001941)3.18696378
82cell differentiation in hindbrain (GO:0021533)3.18048924
83regulation of neurotransmitter transport (GO:0051588)3.16533906
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15844923
85vesicle docking involved in exocytosis (GO:0006904)3.15254664
86synaptic vesicle transport (GO:0048489)3.14478311
87establishment of synaptic vesicle localization (GO:0097480)3.14478311
88positive regulation of dendritic spine development (GO:0060999)3.13746065
89regulation of dendritic spine development (GO:0060998)3.13458392
90membrane depolarization during action potential (GO:0086010)3.13429697
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12718036
92activation of protein kinase A activity (GO:0034199)3.11467712
93membrane hyperpolarization (GO:0060081)3.10949902
94axonal fasciculation (GO:0007413)3.10371234
95positive regulation of dendrite development (GO:1900006)3.09537802
96learning (GO:0007612)3.09061125
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08059388
98neurotransmitter uptake (GO:0001504)3.07654696
99proline transport (GO:0015824)3.06402874
100response to auditory stimulus (GO:0010996)3.05938601
101regulation of synaptic transmission (GO:0050804)3.03649906
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03591636
103dicarboxylic acid transport (GO:0006835)3.02831092
104regulation of voltage-gated calcium channel activity (GO:1901385)3.02526480
105regulation of ARF protein signal transduction (GO:0032012)3.01057609
106cell communication by electrical coupling (GO:0010644)3.00998336
107prepulse inhibition (GO:0060134)3.00854298
108cytoskeletal anchoring at plasma membrane (GO:0007016)3.00784902
109detection of calcium ion (GO:0005513)3.00509031
110chemosensory behavior (GO:0007635)3.00373021
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99955364
112positive regulation of neurotransmitter secretion (GO:0001956)2.99811896
113regulation of exocytosis (GO:0017157)2.99742460
114positive regulation of neurotransmitter transport (GO:0051590)2.97142302
115potassium ion import (GO:0010107)2.96239683
116behavioral defense response (GO:0002209)2.96086838
117behavioral fear response (GO:0001662)2.96086838
118positive regulation of synaptic transmission (GO:0050806)2.95066949
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94142258
120synaptic transmission (GO:0007268)2.93497749
121neuromuscular process (GO:0050905)2.92834046
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91729081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87817306
2GBX2_23144817_ChIP-Seq_PC3_Human3.23825355
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15120928
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13402634
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09595704
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80873106
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80873106
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.79270175
9DROSHA_22980978_ChIP-Seq_HELA_Human2.74629846
10REST_21632747_ChIP-Seq_MESCs_Mouse2.73205119
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67849148
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61690198
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61392509
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59265776
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55908652
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50707120
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.48277942
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.48221210
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.38006925
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37550545
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.29150490
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.26623407
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.25895003
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05882073
25* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01355129
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00107975
27AR_21572438_ChIP-Seq_LNCaP_Human1.92332366
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73189390
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69463486
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.57928012
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52646601
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49026871
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48090707
34SMAD4_21799915_ChIP-Seq_A2780_Human1.46366111
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45897170
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43231791
37LXR_22292898_ChIP-Seq_THP-1_Human1.40718279
38TAF15_26573619_Chip-Seq_HEK293_Human1.35816646
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34910386
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.34043915
41* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33785170
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30988087
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29280761
44* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22757436
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22715231
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22359628
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22029561
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21796203
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19836437
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19709316
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.19022634
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.18880964
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18419528
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17557093
55ZNF274_21170338_ChIP-Seq_K562_Hela1.17336286
56STAT3_23295773_ChIP-Seq_U87_Human1.16634447
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16551929
58AR_19668381_ChIP-Seq_PC3_Human1.15945362
59KDM2B_26808549_Chip-Seq_K562_Human1.15164358
60* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14820949
61P300_19829295_ChIP-Seq_ESCs_Human1.14749618
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.13429077
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.13257394
64SMC4_20622854_ChIP-Seq_HELA_Human1.12428394
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12371059
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12066214
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11960149
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10845224
69OCT4_19829295_ChIP-Seq_ESCs_Human1.10393294
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.10172157
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09636081
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09587549
73AR_25329375_ChIP-Seq_VCAP_Human1.09564337
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09499128
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08552814
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07108236
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06732514
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06540757
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06537279
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02802700
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02755323
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02290792
83P68_20966046_ChIP-Seq_HELA_Human1.02189516
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.01768473
85TCF4_23295773_ChIP-Seq_U87_Human1.01254958
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01025346
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00906112
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00443343
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00047165
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98819605
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98444602
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.97826701
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.97536356
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.97415153
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95709683
96RNF2_27304074_Chip-Seq_NSC_Mouse0.95607781
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95494530
98CREB1_26743006_Chip-Seq_LNCaP_Human0.94683330
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93043181
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.92233712
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92211062
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.91894943
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.91647965
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91220071
105SMAD4_21741376_ChIP-Seq_HESCs_Human0.90942510
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90220858
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.90211433
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.88680254
109CTCF_27219007_Chip-Seq_Bcells_Human0.88594888
110RUNX2_22187159_ChIP-Seq_PCA_Human0.88481738
111TP53_16413492_ChIP-PET_HCT116_Human0.88249661
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.87954046
113KLF4_19829295_ChIP-Seq_ESCs_Human0.86889027
114AHR_22903824_ChIP-Seq_MCF-7_Human0.86244402
115TET1_21451524_ChIP-Seq_MESCs_Mouse0.85647888
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84101256
117RXR_22108803_ChIP-Seq_LS180_Human0.84094755
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83999133
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83697912
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83289275
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81754900
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81231201
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80361404
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80230570
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80230570
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79107020
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78982880
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76862001
129KDM2B_26808549_Chip-Seq_DND41_Human0.76158437
130SMAD4_21741376_ChIP-Seq_ESCs_Human0.75978821
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75771905
132NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75283051
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.74130480
134MYC_19915707_ChIP-ChIP_AK7_Human0.73396101
135CTCF_20526341_ChIP-Seq_ESCs_Human0.72630576
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.70765351
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70445027
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70093003
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69946125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.95654513
2MP0003880_abnormal_central_pattern5.00258380
3MP0003635_abnormal_synaptic_transmissio4.28843586
4MP0004270_analgesia3.71606560
5MP0009745_abnormal_behavioral_response3.55432693
6MP0002064_seizures3.34422453
7MP0002063_abnormal_learning/memory/cond3.32595468
8MP0009046_muscle_twitch3.19988691
9MP0002822_catalepsy2.92294677
10MP0002272_abnormal_nervous_system2.85368820
11MP0002572_abnormal_emotion/affect_behav2.82702426
12MP0005423_abnormal_somatic_nervous2.80890036
13MP0001968_abnormal_touch/_nociception2.73845973
14MP0001486_abnormal_startle_reflex2.70503111
15MP0002734_abnormal_mechanical_nocicepti2.55141208
16MP0001501_abnormal_sleep_pattern2.35416652
17MP0008569_lethality_at_weaning2.27019758
18MP0001440_abnormal_grooming_behavior2.23123906
19MP0002735_abnormal_chemical_nociception2.04940878
20MP0002736_abnormal_nociception_after2.04925131
21MP0002067_abnormal_sensory_capabilities1.97609007
22MP0003329_amyloid_beta_deposits1.95346200
23MP0001970_abnormal_pain_threshold1.92678389
24MP0002733_abnormal_thermal_nociception1.90106129
25MP0004885_abnormal_endolymph1.78616697
26MP0000778_abnormal_nervous_system1.75809363
27MP0002184_abnormal_innervation1.72403298
28MP0002557_abnormal_social/conspecific_i1.71560211
29MP0004924_abnormal_behavior1.70042977
30MP0005386_behavior/neurological_phenoty1.70042977
31MP0004811_abnormal_neuron_physiology1.65738040
32MP0009780_abnormal_chondrocyte_physiolo1.63444926
33MP0000955_abnormal_spinal_cord1.56428156
34MP0000920_abnormal_myelination1.54746800
35MP0005646_abnormal_pituitary_gland1.54733744
36MP0003123_paternal_imprinting1.54448922
37MP0002909_abnormal_adrenal_gland1.52980896
38MP0004142_abnormal_muscle_tone1.52822973
39MP0003879_abnormal_hair_cell1.52150872
40MP0001905_abnormal_dopamine_level1.49670533
41MP0002066_abnormal_motor_capabilities/c1.49664110
42MP0001502_abnormal_circadian_rhythm1.48894225
43MP0002882_abnormal_neuron_morphology1.46568274
44MP0004858_abnormal_nervous_system1.44263698
45MP0003787_abnormal_imprinting1.43915006
46MP0003633_abnormal_nervous_system1.43209006
47MP0001529_abnormal_vocalization1.40211976
48MP0001984_abnormal_olfaction1.36453639
49MP0005645_abnormal_hypothalamus_physiol1.30388395
50MP0003631_nervous_system_phenotype1.25648568
51MP0004145_abnormal_muscle_electrophysio1.24598513
52MP0006276_abnormal_autonomic_nervous1.24526553
53MP0003690_abnormal_glial_cell1.17171488
54MP0004742_abnormal_vestibular_system1.15138602
55MP0002229_neurodegeneration1.12747878
56MP0002152_abnormal_brain_morphology1.10729183
57MP0005409_darkened_coat_color1.10145257
58MP0005551_abnormal_eye_electrophysiolog1.09128950
59MP0003122_maternal_imprinting1.07219865
60MP0001188_hyperpigmentation1.02476437
61MP0003632_abnormal_nervous_system1.01972856
62MP0003075_altered_response_to1.00848600
63MP0003634_abnormal_glial_cell1.00735818
64MP0008872_abnormal_physiological_respon0.99201490
65MP0002069_abnormal_eating/drinking_beha0.96457856
66MP0004147_increased_porphyrin_level0.94844039
67MP0008874_decreased_physiological_sensi0.93272546
68MP0001177_atelectasis0.92085713
69MP0001485_abnormal_pinna_reflex0.90637391
70MP0000751_myopathy0.90238225
71MP0001986_abnormal_taste_sensitivity0.89166446
72MP0008877_abnormal_DNA_methylation0.87892698
73MP0001963_abnormal_hearing_physiology0.86644461
74MP0000604_amyloidosis0.83669097
75MP0005535_abnormal_body_temperature0.82060586
76MP0000013_abnormal_adipose_tissue0.78941814
77MP0004085_abnormal_heartbeat0.78765230
78MP0002752_abnormal_somatic_nervous0.78352964
79MP0001346_abnormal_lacrimal_gland0.77475188
80MP0008961_abnormal_basal_metabolism0.76020202
81MP0004043_abnormal_pH_regulation0.74890506
82MP0003283_abnormal_digestive_organ0.71727638
83MP0002090_abnormal_vision0.70480832
84MP0001348_abnormal_lacrimal_gland0.68095987
85MP0010386_abnormal_urinary_bladder0.67327580
86MP0000631_abnormal_neuroendocrine_gland0.67174426
87MP0004510_myositis0.66814152
88MP0003137_abnormal_impulse_conducting0.66701874
89MP0005171_absent_coat_pigmentation0.66366266
90MP0002638_abnormal_pupillary_reflex0.62626531
91MP0003121_genomic_imprinting0.62274994
92MP0001664_abnormal_digestion0.60333798
93MP0005167_abnormal_blood-brain_barrier0.58986066
94MP0004130_abnormal_muscle_cell0.57919158
95MP0000639_abnormal_adrenal_gland0.56751945
96MP0004215_abnormal_myocardial_fiber0.56652317
97MP0005394_taste/olfaction_phenotype0.55530765
98MP0005499_abnormal_olfactory_system0.55530765
99MP0010769_abnormal_survival0.54861381
100MP0000747_muscle_weakness0.54653811
101MP0004484_altered_response_of0.53948391
102MP0006072_abnormal_retinal_apoptosis0.53945037
103MP0001299_abnormal_eye_distance/0.53660613
104MP0000026_abnormal_inner_ear0.53222449
105MP0001943_abnormal_respiration0.52155914
106MP0002876_abnormal_thyroid_physiology0.52133336
107MP0010768_mortality/aging0.51564277
108MP0003956_abnormal_body_size0.51304563
109MP0002082_postnatal_lethality0.50459739
110MP0010770_preweaning_lethality0.50459739
111MP0005623_abnormal_meninges_morphology0.50211813
112MP0000566_synostosis0.49948510
113MP0002653_abnormal_ependyma_morphology0.49814353
114MP0003172_abnormal_lysosome_physiology0.48194848
115MP0002249_abnormal_larynx_morphology0.48190379
116MP0003861_abnormal_nervous_system0.45758460
117MP0002089_abnormal_postnatal_growth/wei0.44665293
118MP0002873_normal_phenotype0.43809853

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.61558423
2Myokymia (HP:0002411)7.38877745
3Focal seizures (HP:0007359)5.71342435
4Visual hallucinations (HP:0002367)5.42453479
5Progressive cerebellar ataxia (HP:0002073)4.95805918
6Epileptic encephalopathy (HP:0200134)4.76067781
7Atonic seizures (HP:0010819)4.48570033
8Action tremor (HP:0002345)4.34555003
9Febrile seizures (HP:0002373)4.09971709
10Supranuclear gaze palsy (HP:0000605)3.99426822
11Absence seizures (HP:0002121)3.94232392
12Dysmetria (HP:0001310)3.78301575
13Gaze-evoked nystagmus (HP:0000640)3.72817149
14Dialeptic seizures (HP:0011146)3.71766048
15Cerebral hypomyelination (HP:0006808)3.66341616
16Generalized tonic-clonic seizures (HP:0002069)3.65461660
17Broad-based gait (HP:0002136)3.63370469
18Ankle clonus (HP:0011448)3.47935935
19Dysdiadochokinesis (HP:0002075)3.40251129
20Impaired vibration sensation in the lower limbs (HP:0002166)3.36198197
21Poor eye contact (HP:0000817)3.29097996
22Tetraplegia (HP:0002445)3.27612973
23Depression (HP:0000716)3.26714520
24Genetic anticipation (HP:0003743)3.23750069
25Neurofibrillary tangles (HP:0002185)3.19341913
26Scanning speech (HP:0002168)3.17322829
27Anxiety (HP:0000739)3.13696847
28Intention tremor (HP:0002080)3.09061417
29Postural instability (HP:0002172)3.07288906
30Spastic gait (HP:0002064)3.04310974
31Abnormal eating behavior (HP:0100738)3.02730917
32Impaired social interactions (HP:0000735)2.97173666
33Abnormal social behavior (HP:0012433)2.97173666
34Urinary bladder sphincter dysfunction (HP:0002839)2.95367970
35Truncal ataxia (HP:0002078)2.94284720
36Abnormality of binocular vision (HP:0011514)2.92475465
37Diplopia (HP:0000651)2.92475465
38Akinesia (HP:0002304)2.89701219
39Cerebral inclusion bodies (HP:0100314)2.86742881
40Hyperventilation (HP:0002883)2.81329077
41Hemiplegia (HP:0002301)2.80611603
42Impaired smooth pursuit (HP:0007772)2.78762907
43Amblyopia (HP:0000646)2.77277233
44Hemiparesis (HP:0001269)2.75057056
45Mutism (HP:0002300)2.74696907
46Abnormality of the lower motor neuron (HP:0002366)2.74677056
47Urinary urgency (HP:0000012)2.66538185
48Abnormality of the corticospinal tract (HP:0002492)2.64675209
49Torticollis (HP:0000473)2.63644650
50Focal dystonia (HP:0004373)2.55903443
51Stereotypic behavior (HP:0000733)2.54832437
52Megalencephaly (HP:0001355)2.54119345
53Abnormality of ocular smooth pursuit (HP:0000617)2.48280115
54Drooling (HP:0002307)2.44885068
55Excessive salivation (HP:0003781)2.44885068
56Ventricular fibrillation (HP:0001663)2.43724142
57Papilledema (HP:0001085)2.41088596
58Bradykinesia (HP:0002067)2.38366670
59Annular pancreas (HP:0001734)2.38314221
60Dysmetric saccades (HP:0000641)2.31196812
61Apathy (HP:0000741)2.29747821
62CNS hypomyelination (HP:0003429)2.29669113
63Progressive inability to walk (HP:0002505)2.28260248
64Impaired vibratory sensation (HP:0002495)2.26357416
65Choreoathetosis (HP:0001266)2.24229050
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.23186889
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23186889
68Epileptiform EEG discharges (HP:0011182)2.21657043
69Craniofacial dystonia (HP:0012179)2.20405635
70Abnormality of saccadic eye movements (HP:0000570)2.19283212
71Lower limb muscle weakness (HP:0007340)2.17269636
72Status epilepticus (HP:0002133)2.17045577
73Limb dystonia (HP:0002451)2.15892718
74Termporal pattern (HP:0011008)2.15416599
75Insidious onset (HP:0003587)2.15416599
76Peripheral hypomyelination (HP:0007182)2.14172658
77Morphological abnormality of the pyramidal tract (HP:0002062)2.13375699
78Absent speech (HP:0001344)2.12285987
79Spinal canal stenosis (HP:0003416)2.10734844
80Neuronal loss in central nervous system (HP:0002529)2.10149991
81Generalized myoclonic seizures (HP:0002123)2.09400755
82EEG with generalized epileptiform discharges (HP:0011198)2.09040272
83Agitation (HP:0000713)2.08059789
84Gait ataxia (HP:0002066)2.04676836
85Diminished motivation (HP:0000745)2.03957536
86Psychosis (HP:0000709)2.00133099
87Clonus (HP:0002169)1.99679004
88Obstructive sleep apnea (HP:0002870)1.99588539
89Hypsarrhythmia (HP:0002521)1.97802952
90Incomplete penetrance (HP:0003829)1.97087696
91Rigidity (HP:0002063)1.96492945
92Insomnia (HP:0100785)1.96100813
93Bundle branch block (HP:0011710)1.94708779
94Pointed chin (HP:0000307)1.94161431
95Polyphagia (HP:0002591)1.93983502
96Lower limb asymmetry (HP:0100559)1.92460887
97Hand muscle atrophy (HP:0009130)1.91580878
98Increased circulating renin level (HP:0000848)1.90447502
99Pheochromocytoma (HP:0002666)1.89002226
100Thickened helices (HP:0000391)1.87302031
101Retinal dysplasia (HP:0007973)1.86540941
102Fetal akinesia sequence (HP:0001989)1.85306573
103Blue irides (HP:0000635)1.82880599
104Rapidly progressive (HP:0003678)1.81703949
105Delusions (HP:0000746)1.81018598
106Amyotrophic lateral sclerosis (HP:0007354)1.79807727
107Abnormal EKG (HP:0003115)1.79202533
108Spastic tetraparesis (HP:0001285)1.78621098
109Sleep apnea (HP:0010535)1.78288442
110Aplasia involving bones of the extremities (HP:0009825)1.77242405
111Aplasia of the phalanges of the hand (HP:0009802)1.77242405
112Upper limb amyotrophy (HP:0009129)1.77213266
113Distal upper limb amyotrophy (HP:0007149)1.77213266
114Unsteady gait (HP:0002317)1.75574419
115Hyperthyroidism (HP:0000836)1.70661614
116Aplasia involving bones of the upper limbs (HP:0009823)1.69425966
117Spastic tetraplegia (HP:0002510)1.68041121
118Dementia (HP:0000726)1.67978133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.69094447
2NTRK34.59555384
3MAP3K93.38472399
4MAP3K42.62097089
5DAPK22.44051080
6PAK62.40895316
7MINK12.32966624
8MARK12.28613499
9MAP2K72.17792909
10PRKD32.02886573
11KSR22.02635323
12NTRK22.00108295
13TNIK1.97342258
14PRPF4B1.95265546
15CAMKK11.88744660
16CDK191.82107826
17RIPK41.74019028
18CDK51.63071090
19NTRK11.58260432
20MAP2K41.54682548
21LATS21.48812567
22OXSR11.45888325
23KSR11.45312196
24MAP3K131.43982802
25PNCK1.42852011
26FES1.42489586
27UHMK11.41125023
28CASK1.37801178
29ARAF1.37303406
30STK381.36964013
31TYRO31.34135492
32CAMKK21.32331421
33MAP3K121.29884930
34DAPK11.28789196
35GRK51.28199337
36PRKCG1.23179000
37PLK21.19980768
38SIK21.15261376
39CAMK2B1.14477611
40MAPK131.13041142
41CAMK11.11973290
42SGK4941.09989636
43SGK2231.09989636
44MAP3K111.07274878
45MAP3K21.06420188
46CAMK2A1.04614328
47PRKCH1.02363741
48CDK181.01577133
49CDK151.01565905
50MARK20.97465102
51STK390.96948380
52CDK140.95037843
53MAPK120.94609659
54STK110.93470266
55PINK10.92008891
56CDK11A0.88897613
57PTK2B0.88651806
58BRSK10.87840341
59LIMK10.86586412
60NEK60.84931587
61PHKG10.83266461
62PHKG20.83266461
63WNK10.80105077
64BRAF0.79032880
65PDK10.77972684
66PAK30.77790417
67ALK0.76905980
68CSNK1G20.76650295
69DYRK1A0.76592875
70PDPK10.75768973
71TAOK10.75617254
72RAF10.72832083
73TNK20.71712674
74CAMK2D0.70434040
75BMPR20.69423158
76SGK10.68904729
77SGK20.68665403
78SGK30.68629019
79TAOK20.68524771
80CAMK2G0.68353655
81RET0.67562724
82MAP3K70.64956858
83MAPKAPK50.62600210
84PKN10.62116588
85MAP3K10.60549919
86TESK10.59595835
87FYN0.56937801
88NME10.55172156
89CAMK40.54160768
90CAMK1G0.52917374
91FGR0.52812841
92CDC42BPA0.52018711
93ROCK20.51668946
94FGFR20.49242205
95RPS6KA30.49015487
96PRKCE0.48571171
97DMPK0.46018328
98PRKD20.44708664
99BCR0.43592259
100MAPK100.43391592
101LMTK20.42754064
102PRKCZ0.42537248
103DAPK30.41752678
104PRKG20.40753664
105MAP2K60.40408581
106PRKCA0.39517618
107CCNB10.36602944
108FER0.35525055
109RIPK10.35110651
110WNK30.34421752
111ICK0.34137323
112WNK40.34044672
113ROCK10.32704149
114PRKACA0.28652339
115PAK10.27956017
116ERBB20.25253569
117PRKG10.25150376
118MAPK80.25014077
119PRKCB0.24784483
120SRC0.24003669

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71924253
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19459458
3Glutamatergic synapse_Homo sapiens_hsa047242.81458667
4Circadian entrainment_Homo sapiens_hsa047132.78549315
5GABAergic synapse_Homo sapiens_hsa047272.75108496
6Long-term potentiation_Homo sapiens_hsa047202.73622334
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69984017
8Olfactory transduction_Homo sapiens_hsa047402.67706358
9Morphine addiction_Homo sapiens_hsa050322.54634465
10Amphetamine addiction_Homo sapiens_hsa050312.53330400
11Salivary secretion_Homo sapiens_hsa049702.21669552
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14651093
13Dopaminergic synapse_Homo sapiens_hsa047282.12044777
14Insulin secretion_Homo sapiens_hsa049111.99717517
15Gastric acid secretion_Homo sapiens_hsa049711.95751875
16Cholinergic synapse_Homo sapiens_hsa047251.91226970
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89510482
18Long-term depression_Homo sapiens_hsa047301.85809900
19Taste transduction_Homo sapiens_hsa047421.76793565
20Cocaine addiction_Homo sapiens_hsa050301.75408889
21Oxytocin signaling pathway_Homo sapiens_hsa049211.65884486
22Serotonergic synapse_Homo sapiens_hsa047261.62534109
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62408817
24Calcium signaling pathway_Homo sapiens_hsa040201.62402468
25Renin secretion_Homo sapiens_hsa049241.58742944
26Vitamin B6 metabolism_Homo sapiens_hsa007501.47386940
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45184483
28GnRH signaling pathway_Homo sapiens_hsa049121.41943445
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37375876
30Collecting duct acid secretion_Homo sapiens_hsa049661.36359033
31cAMP signaling pathway_Homo sapiens_hsa040241.32027266
32Nitrogen metabolism_Homo sapiens_hsa009101.31741008
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30975679
34Gap junction_Homo sapiens_hsa045401.26474593
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25614709
36Type II diabetes mellitus_Homo sapiens_hsa049301.21010931
37Axon guidance_Homo sapiens_hsa043601.17900761
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14525169
39Estrogen signaling pathway_Homo sapiens_hsa049151.05583752
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03993086
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02156193
42ErbB signaling pathway_Homo sapiens_hsa040121.01923481
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00993225
44Melanogenesis_Homo sapiens_hsa049160.99761975
45Glioma_Homo sapiens_hsa052140.99514362
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.98942665
47Cardiac muscle contraction_Homo sapiens_hsa042600.96571109
48Pancreatic secretion_Homo sapiens_hsa049720.95544149
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.94722546
50Phototransduction_Homo sapiens_hsa047440.92329610
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86374855
52Vibrio cholerae infection_Homo sapiens_hsa051100.85950101
53Dorso-ventral axis formation_Homo sapiens_hsa043200.82731973
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79186287
55Choline metabolism in cancer_Homo sapiens_hsa052310.77442691
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77241665
57MAPK signaling pathway_Homo sapiens_hsa040100.73327713
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72980652
59Oocyte meiosis_Homo sapiens_hsa041140.71527430
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70997912
61Dilated cardiomyopathy_Homo sapiens_hsa054140.68275989
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67705554
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67169046
64Circadian rhythm_Homo sapiens_hsa047100.63885057
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63136079
66VEGF signaling pathway_Homo sapiens_hsa043700.63097085
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60712327
68Ras signaling pathway_Homo sapiens_hsa040140.59550721
69Inositol phosphate metabolism_Homo sapiens_hsa005620.59124572
70Endocytosis_Homo sapiens_hsa041440.58707023
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57245840
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.57031677
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.53270670
74Rap1 signaling pathway_Homo sapiens_hsa040150.52566244
75Arginine and proline metabolism_Homo sapiens_hsa003300.52482092
76Bile secretion_Homo sapiens_hsa049760.47463583
77Alcoholism_Homo sapiens_hsa050340.47301017
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45176595
79Arginine biosynthesis_Homo sapiens_hsa002200.45148941
80Wnt signaling pathway_Homo sapiens_hsa043100.42816902
81Renal cell carcinoma_Homo sapiens_hsa052110.41728532
82Type I diabetes mellitus_Homo sapiens_hsa049400.41577918
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41474330
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41271274
85Glucagon signaling pathway_Homo sapiens_hsa049220.41176818
86Chemokine signaling pathway_Homo sapiens_hsa040620.40409935
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40348372
88Ovarian steroidogenesis_Homo sapiens_hsa049130.38034781
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37898143
90Prion diseases_Homo sapiens_hsa050200.37504081
91Non-small cell lung cancer_Homo sapiens_hsa052230.36340318
92mTOR signaling pathway_Homo sapiens_hsa041500.35796393
93African trypanosomiasis_Homo sapiens_hsa051430.35595346
94Oxidative phosphorylation_Homo sapiens_hsa001900.35019863
95Alzheimers disease_Homo sapiens_hsa050100.33417339
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33076238
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.32888142
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32372999
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31486751
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31425750
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30661243
102beta-Alanine metabolism_Homo sapiens_hsa004100.29057167
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28849935
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27721540
105AMPK signaling pathway_Homo sapiens_hsa041520.27056659
106T cell receptor signaling pathway_Homo sapiens_hsa046600.26687303
107Parkinsons disease_Homo sapiens_hsa050120.26384658
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25804749
109Mineral absorption_Homo sapiens_hsa049780.24014939
110Insulin signaling pathway_Homo sapiens_hsa049100.21852938
111Fatty acid biosynthesis_Homo sapiens_hsa000610.21379924
112Hippo signaling pathway_Homo sapiens_hsa043900.17621086
113HIF-1 signaling pathway_Homo sapiens_hsa040660.16135268

Most similar genes based on co-expression Upload to Enrichr

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