PRRT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of histone deacetylation (GO:0031065)9.48863927
2cardiac right ventricle morphogenesis (GO:0003215)9.19378095
3N-acetylneuraminate metabolic process (GO:0006054)9.14374035
4cellular response to lithium ion (GO:0071285)8.77900094
5negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)7.60889327
6regulation of MHC class II biosynthetic process (GO:0045346)7.50861463
7centriole replication (GO:0007099)7.44230171
8positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)7.32238985
9insulin-like growth factor receptor signaling pathway (GO:0048009)7.26583197
10killing of cells in other organism involved in symbiotic interaction (GO:0051883)7.21045135
11disruption of cells of other organism involved in symbiotic interaction (GO:0051818)7.21045135
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)6.96332592
13mitochondrion transport along microtubule (GO:0047497)6.96332592
14positive regulation of protein deacetylation (GO:0090312)6.90635686
15regulation of chemokine biosynthetic process (GO:0045073)6.87158493
16negative regulation of phagocytosis (GO:0050765)6.69226724
17cytoskeletal anchoring at plasma membrane (GO:0007016)6.55614534
18negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.50786667
19modulation of growth of symbiont involved in interaction with host (GO:0044144)6.50786667
20regulation of growth of symbiont in host (GO:0044126)6.50786667
21negative regulation of growth of symbiont in host (GO:0044130)6.50786667
22amino sugar catabolic process (GO:0046348)6.47699123
23response to parathyroid hormone (GO:0071107)6.42736111
24establishment of mitochondrion localization (GO:0051654)6.30116940
25base-excision repair, AP site formation (GO:0006285)6.13006675
26microglial cell activation (GO:0001774)6.04132494
27purine deoxyribonucleotide catabolic process (GO:0009155)6.02700871
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.79785118
29response to lithium ion (GO:0010226)5.63950309
30embryonic camera-type eye development (GO:0031076)5.54334328
31neutrophil mediated immunity (GO:0002446)5.51230593
32reactive oxygen species biosynthetic process (GO:1903409)5.45543348
33enteric nervous system development (GO:0048484)5.34284669
34thalamus development (GO:0021794)5.33444775
35macrophage chemotaxis (GO:0048246)5.30143012
36cytokinetic process (GO:0032506)5.29299390
37centriole assembly (GO:0098534)5.22055548
38heme biosynthetic process (GO:0006783)5.12283855
39N-acetylglucosamine metabolic process (GO:0006044)5.01319408
40homocysteine metabolic process (GO:0050667)4.99003922
41defense response to fungus (GO:0050832)4.98527594
42regulation of histone deacetylation (GO:0031063)4.88379706
43negative regulation of interleukin-2 production (GO:0032703)4.81048025
44tooth mineralization (GO:0034505)4.80975754
45positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.79160026
46mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.79160026
47glial cell migration (GO:0008347)4.67188274
48smooth muscle cell differentiation (GO:0051145)4.63010597
49negative regulation of histone acetylation (GO:0035067)4.62592602
50induction of positive chemotaxis (GO:0050930)4.55746979
51angiotensin maturation (GO:0002003)4.53111147
52positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.49482865
53protein maturation by protein folding (GO:0022417)4.48890331
54heart field specification (GO:0003128)4.42629548
55secondary heart field specification (GO:0003139)4.42629548
56cell migration involved in heart development (GO:0060973)4.39487013
57hair cycle (GO:0042633)4.38954820
58molting cycle (GO:0042303)4.38954820
59behavioral response to nicotine (GO:0035095)4.34786263
60low-density lipoprotein particle clearance (GO:0034383)4.33194962
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.25758551
62regulation of fatty acid transport (GO:2000191)4.20414497
63cardiac ventricle morphogenesis (GO:0003208)4.18614914
64folic acid metabolic process (GO:0046655)4.17077274
65bone trabecula formation (GO:0060346)4.14270223
66killing of cells of other organism (GO:0031640)4.08978464
67disruption of cells of other organism (GO:0044364)4.08978464
68fatty acid homeostasis (GO:0055089)4.07224911
69patterning of blood vessels (GO:0001569)4.05230929
70porphyrin-containing compound biosynthetic process (GO:0006779)4.01485259
71myeloid leukocyte mediated immunity (GO:0002444)3.96232170
72peripheral nervous system neuron development (GO:0048935)3.94387814
73positive regulation of mitochondrial membrane permeability (GO:0035794)3.94234394
74negative regulation of peptidyl-lysine acetylation (GO:2000757)3.91574866
75DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.88518297
76layer formation in cerebral cortex (GO:0021819)3.87429436
77synaptic vesicle maturation (GO:0016188)3.87238380
78ribosomal small subunit biogenesis (GO:0042274)3.85843769
79cellular response to cadmium ion (GO:0071276)3.85394130
80positive regulation of DNA-templated transcription, initiation (GO:2000144)3.83446883
81response to misfolded protein (GO:0051788)3.78752998
82ventricular trabecula myocardium morphogenesis (GO:0003222)3.77264794
83cardiac chamber morphogenesis (GO:0003206)3.76343737
84I-kappaB phosphorylation (GO:0007252)3.73839332
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73429609
86regulation of protein import into nucleus, translocation (GO:0033158)3.71533410
87negative regulation of protein localization to cell surface (GO:2000009)3.70017689
88response to fungus (GO:0009620)3.65834193
89positive regulation of fatty acid beta-oxidation (GO:0032000)3.64421019
90vocalization behavior (GO:0071625)3.62156427
91opsonization (GO:0008228)3.60038014
92cell migration in hindbrain (GO:0021535)3.57830367
93response to folic acid (GO:0051593)3.55189139
94locomotory exploration behavior (GO:0035641)3.54829949
95DNA damage response, signal transduction resulting in transcription (GO:0042772)3.54449858
96removal of superoxide radicals (GO:0019430)3.54082295
97cellular response to superoxide (GO:0071451)3.54082295
98cellular response to oxygen radical (GO:0071450)3.54082295
99regulation of sequestering of triglyceride (GO:0010889)3.51614749
100regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48801037
101regulation of sarcomere organization (GO:0060297)3.48178366
102regulation of synaptic vesicle exocytosis (GO:2000300)3.48167797
103regulation of synapse structural plasticity (GO:0051823)3.47543860
104tetrapyrrole biosynthetic process (GO:0033014)3.47420687
105mitochondrion localization (GO:0051646)3.43315458
106response to oxygen radical (GO:0000305)3.43158399
107deoxyribonucleotide catabolic process (GO:0009264)3.40677042
108positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36384235
109heme metabolic process (GO:0042168)3.36022014
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33528036
111positive regulation of bone mineralization (GO:0030501)3.30319822
112positive regulation of transcription regulatory region DNA binding (GO:2000679)3.30230345
113regulation of protein deacetylation (GO:0090311)3.28312562
114endocardial cushion morphogenesis (GO:0003203)3.24943627
115regulation of glutamate receptor signaling pathway (GO:1900449)3.24679346
116low-density lipoprotein particle remodeling (GO:0034374)3.22118497
117nodal signaling pathway (GO:0038092)3.21267349
118regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.20374579
119positive regulation of glomerulus development (GO:0090193)3.20290351
120cardiac ventricle formation (GO:0003211)3.19631326
121negative regulation of protein acetylation (GO:1901984)3.19385022
122pyrimidine nucleobase catabolic process (GO:0006208)3.16364731
123positive regulation of hair follicle development (GO:0051798)3.15585380
124positive regulation of hair cycle (GO:0042635)3.15585380
125deoxyribose phosphate catabolic process (GO:0046386)3.12643343
126sympathetic nervous system development (GO:0048485)3.11950440
127signal complex assembly (GO:0007172)3.11593943
128response to food (GO:0032094)3.11501443
129protein localization to synapse (GO:0035418)3.09826996
130hematopoietic stem cell proliferation (GO:0071425)3.08985009
131dendritic spine morphogenesis (GO:0060997)3.07543298
132positive regulation of biomineral tissue development (GO:0070169)3.07091135
133regulation of glycolytic process (GO:0006110)3.07014334
134purine deoxyribonucleotide metabolic process (GO:0009151)3.03677885
135apoptotic process involved in morphogenesis (GO:0060561)3.03468878
136negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.02024374
137dendrite morphogenesis (GO:0048813)2.99741507
138cardiac chamber formation (GO:0003207)2.99454112
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97969914
140positive regulation of tumor necrosis factor production (GO:0032760)2.95184093
141S-adenosylmethionine metabolic process (GO:0046500)2.94238873
142sarcoplasmic reticulum calcium ion transport (GO:0070296)2.92606277
143negative regulation of cell cycle arrest (GO:0071157)2.92006863
144cell communication by electrical coupling (GO:0010644)2.90683658
145chaperone-mediated protein transport (GO:0072321)2.89123077
146glutamate secretion (GO:0014047)2.89084656
147cellular response to nerve growth factor stimulus (GO:1990090)2.88237865
148response to nerve growth factor (GO:1990089)2.88237865
149cartilage morphogenesis (GO:0060536)2.87722184
150polyol transport (GO:0015791)2.87299227
151positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.87190998
152neuron recognition (GO:0008038)2.86640880
153cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.85964566
154triglyceride biosynthetic process (GO:0019432)2.83696317
155regulation of synaptic vesicle transport (GO:1902803)2.83134848
156negative regulation of cAMP-mediated signaling (GO:0043951)2.83133740
157organelle transport along microtubule (GO:0072384)2.82460150
158regulation of secondary heart field cardioblast proliferation (GO:0003266)2.81756536
159regulation of cardioblast proliferation (GO:0003264)2.81756536
160activin receptor signaling pathway (GO:0032924)2.81586332
161porphyrin-containing compound metabolic process (GO:0006778)2.81224261
162hydrogen peroxide catabolic process (GO:0042744)2.80746091
163regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80149493
164neuron cell-cell adhesion (GO:0007158)2.79390387
165phenol-containing compound catabolic process (GO:0019336)2.79163524
166specification of organ identity (GO:0010092)2.78832968
167positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.77598995
168UV protection (GO:0009650)2.77565454
169response to superoxide (GO:0000303)2.76466554
170heart trabecula morphogenesis (GO:0061384)2.76130076
171glucosamine-containing compound metabolic process (GO:1901071)2.74658179
172exploration behavior (GO:0035640)2.73665544
173postsynaptic membrane organization (GO:0001941)2.73341727
174negative regulation of microtubule polymerization (GO:0031115)2.69581906
175positive regulation of muscle hypertrophy (GO:0014742)2.69158177
176positive regulation of cardiac muscle hypertrophy (GO:0010613)2.69158177
177protein heterotrimerization (GO:0070208)2.69152140
178synaptic vesicle exocytosis (GO:0016079)2.67223620
179neurotransmitter-gated ion channel clustering (GO:0072578)2.65751594
1804-hydroxyproline metabolic process (GO:0019471)2.64620071
181neurotransmitter secretion (GO:0007269)2.62453312
182adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62369251
183cardiac muscle contraction (GO:0060048)2.61781970
184cellular respiration (GO:0045333)2.61387189
185positive regulation of synapse maturation (GO:0090129)2.57318675
186response to water (GO:0009415)2.56262769
187regulation of synaptic plasticity (GO:0048167)2.56257829
188regulation of clathrin-mediated endocytosis (GO:2000369)2.55893129
189regulation of DNA-templated transcription, initiation (GO:2000142)2.54198546
190positive regulation of chemokine biosynthetic process (GO:0045080)2.50166576
191nucleobase catabolic process (GO:0046113)2.50126180
192positive regulation of osteoblast differentiation (GO:0045669)2.48434263
193gamma-aminobutyric acid transport (GO:0015812)2.48303796
194hemoglobin metabolic process (GO:0020027)2.48054786
195regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47505179
196protoporphyrinogen IX biosynthetic process (GO:0006782)12.0385552
197cellular extravasation (GO:0045123)10.4248831
198protoporphyrinogen IX metabolic process (GO:0046501)10.1252175

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.05702945
2EZH2_22144423_ChIP-Seq_EOC_Human4.85338910
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.46645981
4VDR_21846776_ChIP-Seq_THP-1_Human3.71391114
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34223287
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.21954674
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09432508
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.97042209
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89568405
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89568405
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82322294
12SCL_19346495_ChIP-Seq_HPC-7_Human2.78893362
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.78156071
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77539421
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.70934911
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.52828589
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.52377128
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49614932
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45799886
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45306639
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.37726575
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.37041113
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36120086
24VDR_24763502_ChIP-Seq_THP-1_Human2.24993697
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19344082
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19003401
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14612935
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.08916319
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08703147
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03072358
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99393228
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94648192
33GBX2_23144817_ChIP-Seq_PC3_Human1.94261323
34REST_21632747_ChIP-Seq_MESCs_Mouse1.81422611
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79961579
36DROSHA_22980978_ChIP-Seq_HELA_Human1.77494593
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72822052
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.72481829
39* TET1_21451524_ChIP-Seq_MESCs_Mouse1.70670889
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70381784
41AR_21572438_ChIP-Seq_LNCaP_Human1.67989247
42LXR_22292898_ChIP-Seq_THP-1_Human1.65963618
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.65855331
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.64940365
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63060871
46SMC4_20622854_ChIP-Seq_HELA_Human1.61915800
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.61268190
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.59291758
49MYC_22102868_ChIP-Seq_BL_Human1.58912599
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.58614328
51P68_20966046_ChIP-Seq_HELA_Human1.56892671
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55509318
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55073085
54* RARB_27405468_Chip-Seq_BRAIN_Mouse1.52963266
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51762147
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51686043
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.50651185
58GATA1_19941826_ChIP-Seq_K562_Human1.48868995
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47735738
60CTCF_27219007_Chip-Seq_Bcells_Human1.46297023
61* RING1B_27294783_Chip-Seq_NPCs_Mouse1.45327895
62BCL6_27268052_Chip-Seq_Bcells_Human1.44358324
63KDM2B_26808549_Chip-Seq_DND41_Human1.42749628
64KDM2B_26808549_Chip-Seq_K562_Human1.41455687
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40757586
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40337129
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38561511
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.37815145
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36303949
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.36063533
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34101871
72CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32218586
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30874610
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.30580303
75* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30413453
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30339999
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.30206441
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30131958
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.27842050
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26756053
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26491473
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26431844
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26262860
84CTCF_26484167_Chip-Seq_Bcells_Mouse1.25002973
85E2F1_20622854_ChIP-Seq_HELA_Human1.24249150
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23957782
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22909859
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22138467
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21345547
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20866996
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20408545
92AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20275636
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.18081987
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17803260
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17666823
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16781339
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.15875502
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15599084
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13648130
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13630434
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12698067
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12477286
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12169692
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11985854
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11160783
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11017942
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10802554
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.10636182
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09075760
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08881642
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08591222
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07948662
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07877131
114RAC3_21632823_ChIP-Seq_H3396_Human1.07498941
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07306837
116TCF7_22412390_ChIP-Seq_EML_Mouse1.07101890
117CTCF_21964334_Chip-Seq_Bcells_Human1.06332994
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05749864
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.05645576
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04506401
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.04258713
122* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03697858
123PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02949624
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02771303
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02551479
126* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02179535
127MAF_26560356_Chip-Seq_TH2_Human1.00167880
128ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99897529
129ZNF274_21170338_ChIP-Seq_K562_Hela0.98850129
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98280746
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.98089653
132CBX2_27304074_Chip-Seq_ESCs_Mouse0.97220934
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97053498
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96771150
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96010057
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95820047
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93990653
138AR_19668381_ChIP-Seq_PC3_Human0.93837712
139FOXP1_21924763_ChIP-Seq_HESCs_Human0.92696026
140RXR_22158963_ChIP-Seq_LIVER_Mouse0.91895013
141SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91238520
142SA1_27219007_Chip-Seq_Bcells_Human0.90662210
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90514147
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.89593843
145AHR_22903824_ChIP-Seq_MCF-7_Human0.89532998
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.86808332
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85577067
148* RNF2_27304074_Chip-Seq_NSC_Mouse0.84792766
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84269162
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84157426
151RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82159518
152SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81440126
153SMAD4_21799915_ChIP-Seq_A2780_Human0.79963029
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.78785368
155* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78684688
156P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78281511
157CREB1_26743006_Chip-Seq_LNCaP_Human0.77747621
158CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77469338
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.77417563
160TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76929499
161IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76900874
162IGF1R_20145208_ChIP-Seq_DFB_Human0.76611606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.38732830
2MP0005670_abnormal_white_adipose7.09299263
3MP0004859_abnormal_synaptic_plasticity4.23481393
4MP0000003_abnormal_adipose_tissue3.26741659
5MP0005365_abnormal_bile_salt3.24293861
6MP0005375_adipose_tissue_phenotype3.15364763
7MP0003122_maternal_imprinting3.06069512
8MP0003123_paternal_imprinting3.02444085
9MP0005666_abnormal_adipose_tissue3.01780366
10MP0004858_abnormal_nervous_system2.97757386
11MP0003787_abnormal_imprinting2.91023314
12MP0006138_congestive_heart_failure2.81953734
13MP0003635_abnormal_synaptic_transmissio2.79058230
14MP0004270_analgesia2.78389250
15MP0008058_abnormal_DNA_repair2.73161673
16MP0003705_abnormal_hypodermis_morpholog2.62119087
17MP0001299_abnormal_eye_distance/2.51097068
18MP0009115_abnormal_fat_cell2.47302048
19MP0002102_abnormal_ear_morphology2.38642205
20MP0003252_abnormal_bile_duct2.38114370
21MP0005187_abnormal_penis_morphology2.37340774
22MP0003303_peritoneal_inflammation2.30971438
23MP0002063_abnormal_learning/memory/cond2.24848584
24MP0000750_abnormal_muscle_regeneration2.24680621
25MP0002009_preneoplasia2.24528587
26MP0003880_abnormal_central_pattern2.24463340
27MP0010329_abnormal_lipoprotein_level2.22951157
28MP0004043_abnormal_pH_regulation2.20776772
29MP0002970_abnormal_white_adipose2.19712730
30MP0002735_abnormal_chemical_nociception2.18416017
31MP0009046_muscle_twitch2.14232332
32MP0009745_abnormal_behavioral_response2.13963116
33MP0000751_myopathy2.12146359
34MP0005334_abnormal_fat_pad2.09864628
35MP0003121_genomic_imprinting2.07434166
36MP0005085_abnormal_gallbladder_physiolo2.06643823
37MP0003890_abnormal_embryonic-extraembry2.02365202
38MP0002909_abnormal_adrenal_gland1.94705608
39MP0005330_cardiomyopathy1.93951572
40MP0002064_seizures1.92293746
41MP0010368_abnormal_lymphatic_system1.90927914
42MP0002638_abnormal_pupillary_reflex1.85551352
43MP0001486_abnormal_startle_reflex1.75475732
44MP0002733_abnormal_thermal_nociception1.71119940
45MP0004133_heterotaxia1.71048113
46MP0003567_abnormal_fetal_cardiomyocyte1.70177252
47MP0003959_abnormal_lean_body1.70092833
48MP0004185_abnormal_adipocyte_glucose1.67203423
49MP0005645_abnormal_hypothalamus_physiol1.63856353
50MP0000778_abnormal_nervous_system1.62878880
51MP0008961_abnormal_basal_metabolism1.58784857
52MP0001502_abnormal_circadian_rhythm1.58271666
53MP0000537_abnormal_urethra_morphology1.58135103
54MP0001968_abnormal_touch/_nociception1.56620609
55MP0005448_abnormal_energy_balance1.55100038
56MP0002572_abnormal_emotion/affect_behav1.54760499
57MP0001501_abnormal_sleep_pattern1.53240105
58MP0003329_amyloid_beta_deposits1.53099980
59MP0004130_abnormal_muscle_cell1.52632160
60MP0002751_abnormal_autonomic_nervous1.51749664
61MP0002184_abnormal_innervation1.49884406
62MP0000516_abnormal_urinary_system1.47367934
63MP0005367_renal/urinary_system_phenotyp1.47367934
64MP0008872_abnormal_physiological_respon1.47165666
65MP0004084_abnormal_cardiac_muscle1.46523980
66MP0001727_abnormal_embryo_implantation1.43915077
67MP0002734_abnormal_mechanical_nocicepti1.42987063
68MP0002837_dystrophic_cardiac_calcinosis1.42411616
69MP0001188_hyperpigmentation1.42095802
70MP0001529_abnormal_vocalization1.39671652
71MP0004885_abnormal_endolymph1.38144395
72MP0001970_abnormal_pain_threshold1.32175928
73MP0005257_abnormal_intraocular_pressure1.28843340
74MP0004085_abnormal_heartbeat1.27292716
75MP0002118_abnormal_lipid_homeostasis1.27111650
76MP0008057_abnormal_DNA_replication1.22179786
77MP0009780_abnormal_chondrocyte_physiolo1.21033220
78MP0002089_abnormal_postnatal_growth/wei1.18816701
79MP0004811_abnormal_neuron_physiology1.17211449
80MP0005423_abnormal_somatic_nervous1.15918963
81MP0002272_abnormal_nervous_system1.14112334
82MP0005452_abnormal_adipose_tissue1.13308748
83MP0001440_abnormal_grooming_behavior1.11896873
84MP0006276_abnormal_autonomic_nervous1.11892020
85MP0005503_abnormal_tendon_morphology1.11002058
86MP0002972_abnormal_cardiac_muscle1.10250422
87MP0004510_myositis1.09875939
88MP0002332_abnormal_exercise_endurance1.08903304
89MP0005535_abnormal_body_temperature1.07809148
90MP0005266_abnormal_metabolism1.05762639
91MP0000538_abnormal_urinary_bladder1.05566639
92MP0004484_altered_response_of1.04824260
93MP0002822_catalepsy1.02898851
94MP0001270_distended_abdomen1.02172687
95MP0000955_abnormal_spinal_cord1.02030615
96MP0003137_abnormal_impulse_conducting1.00511944
97MP0002067_abnormal_sensory_capabilities1.00406880
98MP0002127_abnormal_cardiovascular_syste0.97940341
99MP0008569_lethality_at_weaning0.96812260
100MP0008775_abnormal_heart_ventricle0.96504368
101MP0005167_abnormal_blood-brain_barrier0.94618192
102MP0001340_abnormal_eyelid_morphology0.94080632
103MP0008007_abnormal_cellular_replicative0.93548061
104MP0005620_abnormal_muscle_contractility0.93530274
105MP0002152_abnormal_brain_morphology0.92671138
106MP0000733_abnormal_muscle_development0.92646896
107MP0000579_abnormal_nail_morphology0.91516401
108MP0002066_abnormal_motor_capabilities/c0.91137757
109MP0009672_abnormal_birth_weight0.90378398
110MP0002078_abnormal_glucose_homeostasis0.89643126
111MP0003879_abnormal_hair_cell0.89563285
112MP0005385_cardiovascular_system_phenoty0.89400996
113MP0001544_abnormal_cardiovascular_syste0.89400996
114MP0004742_abnormal_vestibular_system0.88866596
115MP0004215_abnormal_myocardial_fiber0.88018808
116MP0004087_abnormal_muscle_fiber0.87478830
117MP0002971_abnormal_brown_adipose0.86862095
118MP0000759_abnormal_skeletal_muscle0.86247146
119MP0003868_abnormal_feces_composition0.86168034
120MP0005623_abnormal_meninges_morphology0.86054700
121MP0003828_pulmonary_edema0.85080124
122MP0005451_abnormal_body_composition0.84567445
123MP0005386_behavior/neurological_phenoty0.83890418
124MP0004924_abnormal_behavior0.83890418
125MP0006036_abnormal_mitochondrial_physio0.83196263
126MP0003045_fibrosis0.81916984
127MP0002882_abnormal_neuron_morphology0.81199964
128MP0003638_abnormal_response/metabolism_0.81095195
129MP0004145_abnormal_muscle_electrophysio0.79757234
130MP0010386_abnormal_urinary_bladder0.78908214
131MP0005248_abnormal_Harderian_gland0.78321846
132MP0005197_abnormal_uvea_morphology0.78014088
133MP0003948_abnormal_gas_homeostasis0.76941510
134MP0002106_abnormal_muscle_physiology0.76497733
135MP0002736_abnormal_nociception_after0.76090596
136MP0002108_abnormal_muscle_morphology0.75525474
137MP0005166_decreased_susceptibility_to0.75448857
138MP0003075_altered_response_to0.75104357
139MP0008438_abnormal_cutaneous_collagen0.74844667
140MP0002557_abnormal_social/conspecific_i0.74240264
141MP0003385_abnormal_body_wall0.74013905
142MP0001905_abnormal_dopamine_level0.70687228
143MP0005076_abnormal_cell_differentiation0.70384945
144MP0002069_abnormal_eating/drinking_beha0.66365790
145MP0002269_muscular_atrophy0.64403867
146MP0009643_abnormal_urine_homeostasis0.64388102
147MP0000343_altered_response_to0.62041482
148MP0003221_abnormal_cardiomyocyte_apopto0.58062193
149MP0005369_muscle_phenotype0.54614388
150MP0003953_abnormal_hormone_level0.53974799
151MP0000598_abnormal_liver_morphology0.52701010
152MP0008874_decreased_physiological_sensi0.51100783
153MP0002419_abnormal_innate_immunity0.49041843
154MP0000249_abnormal_blood_vessel0.48508034
155MP0009703_decreased_birth_body0.48130657
156MP0005584_abnormal_enzyme/coenzyme_acti0.48081647
157MP0004782_abnormal_surfactant_physiolog0.47044546
158MP0001664_abnormal_digestion0.38158578
159MP0010307_abnormal_tumor_latency0.37826147
160MP0003786_premature_aging0.36343733
161MP0010630_abnormal_cardiac_muscle0.35930840
162MP0002877_abnormal_melanocyte_morpholog0.35559851
163MP0003011_delayed_dark_adaptation0.35338013
164MP0002249_abnormal_larynx_morphology0.33044482
165MP0000609_abnormal_liver_physiology0.32909021
166MP0000681_abnormal_thyroid_gland0.31613101

Predicted human phenotypes

RankGene SetZ-score
1Turricephaly (HP:0000262)6.56668224
2Neonatal hypoglycemia (HP:0001998)6.02796900
3Abnormality of homocysteine metabolism (HP:0010919)5.60650000
4Homocystinuria (HP:0002156)5.60650000
5Split foot (HP:0001839)5.58808802
6Oligodactyly (HP:0012165)5.39088554
7Oligodactyly (hands) (HP:0001180)5.06231452
8Focal motor seizures (HP:0011153)4.70993597
9Abnormality of the prostate (HP:0008775)4.66517621
10Generalized hyperpigmentation (HP:0007440)4.48666068
11Failure to thrive in infancy (HP:0001531)4.42983827
12Protruding tongue (HP:0010808)4.30922801
13Myokymia (HP:0002411)4.14997207
14Natal tooth (HP:0000695)4.11718324
15Choanal stenosis (HP:0000452)3.95587891
16Long toe (HP:0010511)3.92556244
17Ureteral stenosis (HP:0000071)3.89050345
18Increased muscle lipid content (HP:0009058)3.86205680
19Mixed hearing impairment (HP:0000410)3.86200721
20Papilledema (HP:0001085)3.74425627
21Ureteral obstruction (HP:0006000)3.72754629
22Focal seizures (HP:0007359)3.58521930
23Absent hand (HP:0004050)3.53408172
24Aqueductal stenosis (HP:0002410)3.45910192
25Progressive inability to walk (HP:0002505)3.37719345
26Neonatal death (HP:0003811)3.37136031
27Striae distensae (HP:0001065)3.29870873
28Cutaneous photosensitivity (HP:0000992)3.19770774
29Pheochromocytoma (HP:0002666)3.18859175
30Abnormality of the parathyroid morphology (HP:0011766)3.12557485
31Macroorchidism (HP:0000053)3.11119416
32Thrombocytosis (HP:0001894)3.09612830
33Back pain (HP:0003418)3.07726263
34Mutism (HP:0002300)3.06441982
35Obstructive lung disease (HP:0006536)3.04104785
36Chronic obstructive pulmonary disease (HP:0006510)3.04104785
37Hypothermia (HP:0002045)3.03370749
38Increased intramyocellular lipid droplets (HP:0012240)3.00586170
39Coronal craniosynostosis (HP:0004440)2.98391859
40Hypertriglyceridemia (HP:0002155)2.97864648
41Chest pain (HP:0100749)2.93436405
42Unilateral renal agenesis (HP:0000122)2.85836219
43Neoplasm of the adrenal cortex (HP:0100641)2.84668806
44Relative macrocephaly (HP:0004482)2.81891418
45Enlarged penis (HP:0000040)2.81824662
46Round ear (HP:0100830)2.79408190
47Visual hallucinations (HP:0002367)2.78719437
48Psychosis (HP:0000709)2.75557869
49Agitation (HP:0000713)2.73005235
50Infantile muscular hypotonia (HP:0008947)2.71818392
51Porencephaly (HP:0002132)2.66697562
52Dysmetric saccades (HP:0000641)2.60721051
53Action tremor (HP:0002345)2.55745342
54Advanced eruption of teeth (HP:0006288)2.53978119
55Hemiplegia (HP:0002301)2.53886699
56Abnormality of male internal genitalia (HP:0000022)2.52374118
57Renal Fanconi syndrome (HP:0001994)2.52372287
58Abnormality of the phalanges of the hallux (HP:0010057)2.52256362
59Bilateral microphthalmos (HP:0007633)2.50850976
60Facial shape deformation (HP:0011334)2.47227877
61Potter facies (HP:0002009)2.47227877
62Cheilitis (HP:0100825)2.45093295
63Hyperlipoproteinemia (HP:0010980)2.44951262
64Increased hepatocellular lipid droplets (HP:0006565)2.44463471
65Clumsiness (HP:0002312)2.43516119
66Epidermoid cyst (HP:0200040)2.43420535
67External ophthalmoplegia (HP:0000544)2.42974939
68Tubulointerstitial fibrosis (HP:0005576)2.42754299
69Increased variability in muscle fiber diameter (HP:0003557)2.42632619
70Partial agenesis of the corpus callosum (HP:0001338)2.39977106
71Absent speech (HP:0001344)2.37031076
72Neuroendocrine neoplasm (HP:0100634)2.35053083
73Prostate neoplasm (HP:0100787)2.35041401
74Supranuclear gaze palsy (HP:0000605)2.34606889
75Abnormal autonomic nervous system physiology (HP:0012332)2.33388483
76Athetosis (HP:0002305)2.32191063
77Genetic anticipation (HP:0003743)2.29224358
78Acanthosis nigricans (HP:0000956)2.29110551
79Periorbital edema (HP:0100539)2.28527040
80Orthostatic hypotension (HP:0001278)2.26672043
81Progressive microcephaly (HP:0000253)2.26430136
82Polycythemia (HP:0001901)2.23501429
83Generalized tonic-clonic seizures (HP:0002069)2.22563271
84Large earlobe (HP:0009748)2.19981416
85Excessive salivation (HP:0003781)2.19628167
86Drooling (HP:0002307)2.19628167
87Hepatosplenomegaly (HP:0001433)2.18864822
88Annular pancreas (HP:0001734)2.18676694
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18210755
90Sudden death (HP:0001699)2.17667122
91Abnormality of chloride homeostasis (HP:0011422)2.16815399
92Thyroid carcinoma (HP:0002890)2.16740261
93Abdominal pain (HP:0002027)2.16319457
94Flat occiput (HP:0005469)2.16177665
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15914685
96Abnormality of glycolysis (HP:0004366)2.15632303
97Abnormality of macular pigmentation (HP:0008002)2.14833581
98Thin skin (HP:0000963)2.14788973
99Adducted thumb (HP:0001181)2.14395400
100Adrenal overactivity (HP:0002717)2.14127821
101Absence seizures (HP:0002121)2.13729884
102Facial edema (HP:0000282)2.12892787
103Protrusio acetabuli (HP:0003179)2.11908882
104Hyperthyroidism (HP:0000836)2.11135895
105Exercise-induced myalgia (HP:0003738)2.10946503
106Increased serum pyruvate (HP:0003542)2.09547107
107High anterior hairline (HP:0009890)2.08998969
108Mesangial abnormality (HP:0001966)2.08424761
109Limited elbow extension (HP:0001377)2.07502111
110Plagiocephaly (HP:0001357)2.07163359
111Split hand (HP:0001171)2.03388208
112Tubulointerstitial abnormality (HP:0001969)2.03266670
113Skull defect (HP:0001362)2.02862043
114Inability to walk (HP:0002540)2.02330680
115Abnormality of skeletal muscle fiber size (HP:0012084)2.00626887
116Exertional dyspnea (HP:0002875)1.99631010
117Amblyopia (HP:0000646)1.99195830
118Breech presentation (HP:0001623)1.98798572
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98715942
120Epileptic encephalopathy (HP:0200134)1.98209190
121Calcaneovalgus deformity (HP:0001848)1.97809786
122Lipid accumulation in hepatocytes (HP:0006561)1.96174667
123Renal cell carcinoma (HP:0005584)1.95801897
124Malnutrition (HP:0004395)1.95153796
125Depression (HP:0000716)1.94456578
126Microvesicular hepatic steatosis (HP:0001414)1.94448620
127Termporal pattern (HP:0011008)1.93586206
128Insidious onset (HP:0003587)1.93586206
129Disproportionate tall stature (HP:0001519)1.93564797
130Abnormality of the heme biosynthetic pathway (HP:0010472)1.93452572
131Metabolic alkalosis (HP:0200114)1.92618151
132Hypoventilation (HP:0002791)1.92535431
133Absent toe (HP:0010760)1.91674425
134Cerebral hemorrhage (HP:0001342)1.91228124
135Myotonia (HP:0002486)1.90897517
136Severe global developmental delay (HP:0011344)1.90673845
137Sporadic (HP:0003745)1.90241636
138Long foot (HP:0001833)1.89550165
139Restlessness (HP:0000711)1.89228836
140Subacute progressive viral hepatitis (HP:0006572)1.88861052
141Death in childhood (HP:0003819)1.88351760
142Skin nodule (HP:0200036)1.88099236
143Pointed chin (HP:0000307)1.87272365
144Fair hair (HP:0002286)1.86068041
145Limb dystonia (HP:0002451)1.85882035
146Stereotypic behavior (HP:0000733)1.85859001
147Adactyly (HP:0009776)1.85428641
148Fragile skin (HP:0001030)1.84862403
149Difficulty running (HP:0009046)1.83583808
150Cerebral inclusion bodies (HP:0100314)1.83495032
151Aplasia involving bones of the extremities (HP:0009825)1.83490425
152Aplasia involving bones of the upper limbs (HP:0009823)1.83490425
153Aplasia of the phalanges of the hand (HP:0009802)1.83490425
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83321972
155Hypercortisolism (HP:0001578)1.83068068
156Onycholysis (HP:0001806)1.82547654
157Hepatocellular carcinoma (HP:0001402)1.82391806
158Broad distal phalanx of finger (HP:0009836)1.80737721
159Buphthalmos (HP:0000557)1.80553551
160Hypokalemic alkalosis (HP:0001949)1.80473828
161Bicornuate uterus (HP:0000813)1.79353206
162Hyperparathyroidism (HP:0000843)1.76850282
163Primary atrial arrhythmia (HP:0001692)1.76644603
164Upper motor neuron abnormality (HP:0002127)1.76529468
165Atrial fibrillation (HP:0005110)1.75724758
166Small hand (HP:0200055)1.73489054
167Amyotrophic lateral sclerosis (HP:0007354)1.73324099
168Obstructive sleep apnea (HP:0002870)1.71986750
169Inappropriate behavior (HP:0000719)1.71675379
170Ventricular fibrillation (HP:0001663)1.71668084
171Spinal cord compression (HP:0002176)1.70466383
172Lower limb amyotrophy (HP:0007210)1.69776606
173Hyperventilation (HP:0002883)1.69549073
174Narrow nasal bridge (HP:0000446)1.69271041
175Broad-based gait (HP:0002136)1.68402781
176Exotropia (HP:0000577)1.68076982
177Abnormality of the lower motor neuron (HP:0002366)1.67978303
178Stroke (HP:0001297)1.67523660
179Poor eye contact (HP:0000817)1.65412409
180Protruding ear (HP:0000411)1.64099392
181Supraventricular tachycardia (HP:0004755)1.63736933
182Dialeptic seizures (HP:0011146)1.63498364
183Torticollis (HP:0000473)1.63051908
184Bronchomalacia (HP:0002780)1.62950374
185Hypophosphatemia (HP:0002148)1.62449719
186Supraventricular arrhythmia (HP:0005115)1.62027244
187Incomplete penetrance (HP:0003829)1.61974936
188Neurofibrillary tangles (HP:0002185)1.61900269
189Recurrent cutaneous fungal infections (HP:0011370)1.61324916
190Chronic mucocutaneous candidiasis (HP:0002728)1.61324916
191Anxiety (HP:0000739)1.59132074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB17.70570683
2PINK17.41873312
3NEK26.66312953
4DAPK25.62122524
5CAMK1D4.97516895
6MAPK74.76562390
7CAMKK24.68867951
8PRPF4B4.66674224
9SMG14.28610468
10CAMK1G3.43512023
11TESK23.10318354
12TAF13.09679662
13VRK23.07387378
14MARK12.92782171
15RPS6KL12.87319821
16RPS6KC12.87319821
17TAOK22.72175068
18RPS6KA62.49187818
19DAPK12.40685274
20NTRK32.09937134
21EPHB22.06504510
22LRRK21.87239102
23ICK1.86467835
24MST1R1.58292413
25DAPK31.56528396
26PHKG21.52442134
27PHKG11.52442134
28EPHA41.46571611
29MAP3K91.39151525
30MAP3K71.36710770
31CLK11.30701727
32CASK1.28612869
33KSR21.26378004
34CHUK1.21978196
35TRIB31.20628216
36AKT31.16530762
37IRAK31.15364479
38LATS21.10909822
39PAK61.08099604
40NTRK21.05040674
41WNK41.04193252
42MINK11.00828522
43PLK41.00199759
44TESK10.98901148
45ERN10.97753827
46MAP3K20.96643023
47GRK50.95289978
48PRKAA20.95194947
49MAPK40.92973252
50EEF2K0.92244191
51CAMK10.86107295
52SIK10.82088623
53SIK20.75824037
54MTOR0.75148448
55TTN0.72320504
56LMTK20.70440823
57CDK50.69839161
58MAP3K40.69755923
59RIPK10.69742895
60PRKD30.67749548
61MAPK90.66846118
62STK110.63279396
63PAK30.63104184
64MUSK0.62663557
65RET0.61935446
66UHMK10.61704598
67TYRO30.61143098
68BMX0.60847276
69YES10.58646880
70MAPK120.58377716
71PDGFRB0.58162199
72NTRK10.58128809
73CSNK1G20.56384845
74CDK150.56381790
75ERBB30.55491330
76CDK180.54281342
77PLK20.52887614
78INSRR0.52588637
79CDK140.51880687
80DYRK20.51539078
81ERBB40.51338702
82CSNK1A1L0.50785263
83KSR10.49036793
84CDK11A0.49005046
85EIF2AK20.48583370
86VRK10.47274578
87MET0.47109565
88MARK20.47089978
89MAPK130.46790211
90NUAK10.45659197
91CAMKK10.44474600
92PRKAA10.43031854
93PDK30.42583271
94PDK40.42583271
95RPS6KB20.41307391
96PKN20.40682301
97DDR20.39832043
98MAP2K30.39274490
99MAP2K40.39159877
100ALK0.38369329
101CDK90.37221267
102SYK0.36188220
103DMPK0.35859331
104RPS6KA30.35760964
105TAOK10.35457617
106PAK20.35167384
107PRKCG0.33945257
108PKN10.32600174
109GRK10.31242913
110MAPK80.31113297
111CAMK2A0.30037942
112CAMK2B0.29732029
113CSNK1G30.29391566
114PRKCH0.28062497
115MELK0.27218635
116CAMK2D0.27149591
117MAP2K70.26792695
118MAP3K100.26448864
119PDPK10.25964069
120INSR0.25443079
121LIMK10.25121693
122PRKACG0.25104771
123CAMK40.24606077
124PRKACA0.24605683
125MAP2K10.24563459
126DYRK1A0.23517252
127TNK20.22372599
128CAMK2G0.21084714
129ABL20.20341393
130AKT10.20287805
131PDGFRA0.19718156
132FYN0.19320045
133SGK10.19176659
134CSK0.18559481
135HIPK20.18303731
136CSNK1G10.17700421
137MAPKAPK50.17489674
138STK40.16234219
139OBSCN0.15952761
140CHEK20.14821741
141DYRK1B0.13994846
142PRKD10.13899892
143MAP3K110.12346400
144PTK20.10695020
145GSK3A0.10506318
146CDK30.10161769
147MAPK140.09380237
148GSK3B0.08919475
149FLT30.07940410
150KIT0.07358331
151WNK10.06921981
152CDK70.06309898
153CDK60.06005616
154CDK40.05934334
155MAP2K20.05733455
156CDK20.05664852
157CSNK1E0.05253315

Predicted pathways (KEGG)

RankGene SetZ-score
1Pyruvate metabolism_Homo sapiens_hsa006203.99793673
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.92734616
3Renin-angiotensin system_Homo sapiens_hsa046143.50768747
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.92469728
5Glycerolipid metabolism_Homo sapiens_hsa005612.77727121
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.71238670
7Axon guidance_Homo sapiens_hsa043602.68951172
8Oxytocin signaling pathway_Homo sapiens_hsa049212.65287247
9PPAR signaling pathway_Homo sapiens_hsa033202.61374945
10Fatty acid biosynthesis_Homo sapiens_hsa000612.52621519
11Propanoate metabolism_Homo sapiens_hsa006402.44192468
12Synaptic vesicle cycle_Homo sapiens_hsa047212.41974857
13Base excision repair_Homo sapiens_hsa034102.38194268
14Phenylalanine metabolism_Homo sapiens_hsa003602.19161026
15Thyroid cancer_Homo sapiens_hsa052162.04956967
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97717882
17Circadian entrainment_Homo sapiens_hsa047131.95462687
18Nicotine addiction_Homo sapiens_hsa050331.94924522
19GABAergic synapse_Homo sapiens_hsa047271.88701542
20One carbon pool by folate_Homo sapiens_hsa006701.79935803
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78598286
22Glutamatergic synapse_Homo sapiens_hsa047241.78468062
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.74439753
24Cholinergic synapse_Homo sapiens_hsa047251.67103573
25Fatty acid elongation_Homo sapiens_hsa000621.63864187
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.61888870
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.56516771
28Cardiac muscle contraction_Homo sapiens_hsa042601.55509129
29Dopaminergic synapse_Homo sapiens_hsa047281.54129401
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52654514
31Amphetamine addiction_Homo sapiens_hsa050311.52466885
32Cocaine addiction_Homo sapiens_hsa050301.51938390
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47913565
34Long-term depression_Homo sapiens_hsa047301.47344310
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47176478
36Lysine degradation_Homo sapiens_hsa003101.47063486
37Tyrosine metabolism_Homo sapiens_hsa003501.46897311
38Histidine metabolism_Homo sapiens_hsa003401.46408054
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46116852
40Long-term potentiation_Homo sapiens_hsa047201.45276776
41Morphine addiction_Homo sapiens_hsa050321.43831630
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41672783
43Dilated cardiomyopathy_Homo sapiens_hsa054141.40996590
44Wnt signaling pathway_Homo sapiens_hsa043101.39872262
45Fatty acid metabolism_Homo sapiens_hsa012121.39785089
46Melanogenesis_Homo sapiens_hsa049161.37710533
47Type II diabetes mellitus_Homo sapiens_hsa049301.37700390
48Salivary secretion_Homo sapiens_hsa049701.37472270
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36738240
50Renin secretion_Homo sapiens_hsa049241.35134890
51Fatty acid degradation_Homo sapiens_hsa000711.33636752
52Olfactory transduction_Homo sapiens_hsa047401.30762364
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29842033
54DNA replication_Homo sapiens_hsa030301.28465490
55Platelet activation_Homo sapiens_hsa046111.25549639
56beta-Alanine metabolism_Homo sapiens_hsa004101.20605521
57Gap junction_Homo sapiens_hsa045401.20290835
58Insulin secretion_Homo sapiens_hsa049111.19047945
59Gastric acid secretion_Homo sapiens_hsa049711.16687398
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16206926
61Glycerophospholipid metabolism_Homo sapiens_hsa005641.15272514
62Rap1 signaling pathway_Homo sapiens_hsa040151.15159309
63GnRH signaling pathway_Homo sapiens_hsa049121.14724988
64Tryptophan metabolism_Homo sapiens_hsa003801.13167157
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12373379
66Alzheimers disease_Homo sapiens_hsa050101.12254102
67Parkinsons disease_Homo sapiens_hsa050121.11466667
68Oxidative phosphorylation_Homo sapiens_hsa001901.09954875
69Phospholipase D signaling pathway_Homo sapiens_hsa040721.08870233
70Serotonergic synapse_Homo sapiens_hsa047261.08310454
71Prion diseases_Homo sapiens_hsa050201.05305966
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04356915
73Estrogen signaling pathway_Homo sapiens_hsa049151.03097969
74Sulfur metabolism_Homo sapiens_hsa009201.02252411
75Taste transduction_Homo sapiens_hsa047421.01036437
76Non-small cell lung cancer_Homo sapiens_hsa052230.96012869
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.95587733
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94369238
79Collecting duct acid secretion_Homo sapiens_hsa049660.94305389
80Calcium signaling pathway_Homo sapiens_hsa040200.93292758
81cAMP signaling pathway_Homo sapiens_hsa040240.93219367
82Hepatitis B_Homo sapiens_hsa051610.93206857
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92220209
84Endometrial cancer_Homo sapiens_hsa052130.88687419
85Carbon metabolism_Homo sapiens_hsa012000.88519075
86Acute myeloid leukemia_Homo sapiens_hsa052210.86534594
87Vibrio cholerae infection_Homo sapiens_hsa051100.85539054
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85329610
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85058328
90HTLV-I infection_Homo sapiens_hsa051660.84202984
91Renal cell carcinoma_Homo sapiens_hsa052110.82837216
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82554145
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82022960
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81748187
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81020332
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80124510
97Focal adhesion_Homo sapiens_hsa045100.79166077
98ErbB signaling pathway_Homo sapiens_hsa040120.78637889
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77460408
100Arginine biosynthesis_Homo sapiens_hsa002200.77292286
101Bile secretion_Homo sapiens_hsa049760.76288814
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75650923
103Amoebiasis_Homo sapiens_hsa051460.75230334
104Glioma_Homo sapiens_hsa052140.75063435
105Alcoholism_Homo sapiens_hsa050340.74772027
106Ovarian steroidogenesis_Homo sapiens_hsa049130.74532013
107Basal cell carcinoma_Homo sapiens_hsa052170.74487167
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.73275740
109Hedgehog signaling pathway_Homo sapiens_hsa043400.71798883
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71578738
111Colorectal cancer_Homo sapiens_hsa052100.70779049
112mTOR signaling pathway_Homo sapiens_hsa041500.70758818
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.68387092
114AMPK signaling pathway_Homo sapiens_hsa041520.68366282
115Proteoglycans in cancer_Homo sapiens_hsa052050.68029474
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67608716
117Glucagon signaling pathway_Homo sapiens_hsa049220.65261254
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63921320
119VEGF signaling pathway_Homo sapiens_hsa043700.63639481
120Phototransduction_Homo sapiens_hsa047440.62260350
121Fat digestion and absorption_Homo sapiens_hsa049750.61139720
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59532933
123Melanoma_Homo sapiens_hsa052180.59523380
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58632191
125Folate biosynthesis_Homo sapiens_hsa007900.58307400
126Chronic myeloid leukemia_Homo sapiens_hsa052200.58151655
127MAPK signaling pathway_Homo sapiens_hsa040100.57548629
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57498217
129Choline metabolism in cancer_Homo sapiens_hsa052310.57402604
130Insulin signaling pathway_Homo sapiens_hsa049100.57287358
131Huntingtons disease_Homo sapiens_hsa050160.57207631
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56114808
133Dorso-ventral axis formation_Homo sapiens_hsa043200.53314986
134Adherens junction_Homo sapiens_hsa045200.52973119
135Ras signaling pathway_Homo sapiens_hsa040140.52622443
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.52378023
137Starch and sucrose metabolism_Homo sapiens_hsa005000.52369618
138Hippo signaling pathway_Homo sapiens_hsa043900.50881970
139Thyroid hormone synthesis_Homo sapiens_hsa049180.50170270
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49964955
141Leishmaniasis_Homo sapiens_hsa051400.48941561
142Sulfur relay system_Homo sapiens_hsa041220.48720644
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48418884
144Phagosome_Homo sapiens_hsa041450.47880587
145Lysosome_Homo sapiens_hsa041420.46958621
146Basal transcription factors_Homo sapiens_hsa030220.46587101
147Tight junction_Homo sapiens_hsa045300.45627685
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44729918
149Caffeine metabolism_Homo sapiens_hsa002320.43251407
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42581515
151FoxO signaling pathway_Homo sapiens_hsa040680.40403778
152Bladder cancer_Homo sapiens_hsa052190.40360862
153Ribosome_Homo sapiens_hsa030100.38434750
154Systemic lupus erythematosus_Homo sapiens_hsa053220.35415229
155Fanconi anemia pathway_Homo sapiens_hsa034600.31029864
156Arginine and proline metabolism_Homo sapiens_hsa003300.28999106
157Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28065576

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