PRRX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.65937981
2bone trabecula formation (GO:0060346)6.12438976
3sequestering of extracellular ligand from receptor (GO:0035581)5.90840067
4collagen fibril organization (GO:0030199)5.76651068
5mesenchymal-epithelial cell signaling (GO:0060638)5.32715756
6axon extension involved in axon guidance (GO:0048846)5.03877184
7neuron projection extension involved in neuron projection guidance (GO:1902284)5.03877184
8craniofacial suture morphogenesis (GO:0097094)4.97704623
9protein heterotrimerization (GO:0070208)4.96268504
10planar cell polarity pathway involved in neural tube closure (GO:0090179)4.88694046
11metanephric mesenchyme development (GO:0072075)4.77633711
12outer ear morphogenesis (GO:0042473)4.73053246
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.68514002
14chondrocyte development (GO:0002063)4.60883513
15extracellular fibril organization (GO:0043206)4.60103366
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.58156348
17kidney mesenchyme development (GO:0072074)4.53854680
18dermatan sulfate biosynthetic process (GO:0030208)4.31915995
19lateral sprouting from an epithelium (GO:0060601)4.21963469
20* embryonic cranial skeleton morphogenesis (GO:0048701)4.18772107
21cranial suture morphogenesis (GO:0060363)4.17905368
22* middle ear morphogenesis (GO:0042474)4.07963616
23negative regulation of chondrocyte differentiation (GO:0032331)4.06369093
24fibril organization (GO:0097435)4.01220625
25extracellular negative regulation of signal transduction (GO:1900116)4.00911735
26extracellular regulation of signal transduction (GO:1900115)4.00911735
27regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.95979463
28dermatan sulfate metabolic process (GO:0030205)3.94406052
29hippo signaling (GO:0035329)3.94286908
30cell migration involved in heart development (GO:0060973)3.93938890
31regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.90816186
32endodermal cell differentiation (GO:0035987)3.84282992
33cell proliferation involved in metanephros development (GO:0072203)3.81625416
34vascular endothelial growth factor signaling pathway (GO:0038084)3.81233834
35body morphogenesis (GO:0010171)3.77032467
36embryonic body morphogenesis (GO:0010172)3.75851759
37keratan sulfate catabolic process (GO:0042340)3.72176527
38mesenchymal cell proliferation (GO:0010463)3.63085382
39glomerular basement membrane development (GO:0032836)3.60068818
40negative regulation of catenin import into nucleus (GO:0035414)3.58229497
41negative regulation of axon extension involved in axon guidance (GO:0048843)3.57932370
42extracellular matrix disassembly (GO:0022617)3.57040749
43Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.55889334
44head development (GO:0060322)3.55165938
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.54572546
46embryonic skeletal joint morphogenesis (GO:0060272)3.53687354
47embryonic forelimb morphogenesis (GO:0035115)3.52723271
48regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.51667934
49peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.51165078
50regulation of non-canonical Wnt signaling pathway (GO:2000050)3.51163233
51regulation of establishment of planar polarity (GO:0090175)3.49379947
52regulation of heart morphogenesis (GO:2000826)3.48918126
53negative chemotaxis (GO:0050919)3.47850740
54glomerular filtration (GO:0003094)3.47227027
55radial glial cell differentiation (GO:0060019)3.46335584
56negative regulation of cartilage development (GO:0061037)3.45366299
57negative regulation of fatty acid transport (GO:2000192)3.44394665
58adhesion of symbiont to host cell (GO:0044650)3.43511267
59virion attachment to host cell (GO:0019062)3.43511267
60regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.43009554
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42623182
62basement membrane organization (GO:0071711)3.41002204
63negative regulation of embryonic development (GO:0045992)3.38773671
64* positive regulation of mesenchymal cell proliferation (GO:0002053)3.36928326
65regulation of extracellular matrix disassembly (GO:0010715)3.34460918
66skin morphogenesis (GO:0043589)3.34378759
67collagen metabolic process (GO:0032963)3.33947492
68collagen catabolic process (GO:0030574)3.31594008
69convergent extension (GO:0060026)3.30731381
70negative regulation of smooth muscle cell migration (GO:0014912)3.30207907
71paraxial mesoderm development (GO:0048339)3.29044148
72blood vessel maturation (GO:0001955)3.26869427
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.26702255
74insulin-like growth factor receptor signaling pathway (GO:0048009)3.25529879
75cartilage morphogenesis (GO:0060536)3.25114931
76negative regulation of DNA repair (GO:0045738)3.24582891
77cochlea morphogenesis (GO:0090103)3.24014821
78type B pancreatic cell proliferation (GO:0044342)3.23997949
79cell proliferation involved in kidney development (GO:0072111)3.23416234
80prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.23370248
81* regulation of mesenchymal cell proliferation (GO:0010464)3.21971599
82substrate-dependent cell migration (GO:0006929)3.18339207
83cell migration involved in sprouting angiogenesis (GO:0002042)3.17699585
84embryonic hindlimb morphogenesis (GO:0035116)3.17355285
85extracellular matrix organization (GO:0030198)3.15933048
86endocardial cushion development (GO:0003197)3.15654586
87mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.15279499
88extracellular structure organization (GO:0043062)3.14752709
89regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.13895585
90bone morphogenesis (GO:0060349)3.13751018
91forelimb morphogenesis (GO:0035136)3.13657311
92hindlimb morphogenesis (GO:0035137)3.13065813
93camera-type eye morphogenesis (GO:0048593)3.11586197
94positive regulation of blood vessel endothelial cell migration (GO:0043536)3.09838502
95multicellular organismal macromolecule metabolic process (GO:0044259)3.09693301
96regulation of cartilage development (GO:0061035)3.07484396
97negative regulation of axon guidance (GO:1902668)3.06496971
98regulation of chondrocyte differentiation (GO:0032330)3.05919009
99cardiac myofibril assembly (GO:0055003)3.05842302
100face morphogenesis (GO:0060325)3.05482361
101positive regulation of epithelial to mesenchymal transition (GO:0010718)3.05079804
102regulation of axon extension involved in axon guidance (GO:0048841)3.04816035
103glial cell migration (GO:0008347)3.04639616
104tooth mineralization (GO:0034505)3.03398823
105retina vasculature morphogenesis in camera-type eye (GO:0061299)3.03385052
106non-canonical Wnt signaling pathway (GO:0035567)3.03324149
107polarized epithelial cell differentiation (GO:0030859)3.01260390
108smooth muscle tissue development (GO:0048745)3.00591022
109multicellular organismal catabolic process (GO:0044243)2.99591851
110eyelid development in camera-type eye (GO:0061029)2.99491143
111barbed-end actin filament capping (GO:0051016)2.99442471
112regulation of catenin import into nucleus (GO:0035412)2.99380000
113renal filtration (GO:0097205)2.99178595
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97297409
115mesenchyme development (GO:0060485)2.94859081
116branching involved in prostate gland morphogenesis (GO:0060442)2.93925708
117regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.93631859
118embryonic digit morphogenesis (GO:0042733)2.92274270
119positive regulation of catenin import into nucleus (GO:0035413)2.92262634
120plasma membrane repair (GO:0001778)2.90371707
121cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.90009661
122multicellular organismal metabolic process (GO:0044236)2.89782285
123cellular response to vitamin (GO:0071295)2.88504328
124extracellular matrix assembly (GO:0085029)2.88125731
125protein localization to cell surface (GO:0034394)2.87808153
126positive regulation of fibroblast migration (GO:0010763)2.84835434
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.84773183
128anatomical structure regression (GO:0060033)2.82631296
129adhesion of symbiont to host (GO:0044406)2.82308406
130endothelial cell morphogenesis (GO:0001886)2.82144304
131substrate adhesion-dependent cell spreading (GO:0034446)2.81119437
132negative regulation of BMP signaling pathway (GO:0030514)2.81093869
133actin-mediated cell contraction (GO:0070252)2.79526716
134cellular response to amino acid stimulus (GO:0071230)2.76499968
135regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.76329332
136chondroitin sulfate biosynthetic process (GO:0030206)2.76001400
137muscle filament sliding (GO:0030049)2.74244667
138actin-myosin filament sliding (GO:0033275)2.74244667
139cell adhesion mediated by integrin (GO:0033627)2.72774059
140chondroitin sulfate catabolic process (GO:0030207)2.72561279
141muscle cell migration (GO:0014812)2.72465950
142positive regulation of osteoblast proliferation (GO:0033690)2.70652200
143wound healing, spreading of epidermal cells (GO:0035313)2.67932044
144myofibril assembly (GO:0030239)2.67281583
145cell-substrate junction assembly (GO:0007044)2.67071935
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67050612
147venous blood vessel morphogenesis (GO:0048845)2.62429085
148lymphangiogenesis (GO:0001946)2.59363413
149regulation of axon guidance (GO:1902667)2.58911682
150stress fiber assembly (GO:0043149)2.58163599
151regulation of integrin-mediated signaling pathway (GO:2001044)2.54751841
152endocrine hormone secretion (GO:0060986)2.54149033
153positive regulation of extracellular matrix organization (GO:1903055)2.50882891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.91349662
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.32728892
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.01996970
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.04340878
5CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse3.02815735
6* WT1_19549856_ChIP-ChIP_CCG9911_Human3.02139065
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84194351
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77248004
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.68967537
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.49700388
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47247427
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.44223681
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.42175795
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.37639214
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.35455578
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.33676532
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.23579265
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.22017801
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17918233
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17918233
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.17473478
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.13660421
23BRD4_25478319_ChIP-Seq_HGPS_Human2.11715607
24* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.08102643
25TP53_18474530_ChIP-ChIP_U2OS_Human2.08022642
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.07384095
27EP300_21415370_ChIP-Seq_HL-1_Mouse2.06741329
28* TP53_20018659_ChIP-ChIP_R1E_Mouse2.06681116
29* EZH2_27304074_Chip-Seq_ESCs_Mouse2.06410420
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02733484
31* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01521264
32* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01521264
33* CJUN_26792858_Chip-Seq_BT549_Human2.00456120
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99129658
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.98965871
36* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86187849
37* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80442704
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80343699
39* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76486013
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76417880
41* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69488641
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64686915
43TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.64408356
44TP53_16413492_ChIP-PET_HCT116_Human1.61024153
45ISL1_27105846_Chip-Seq_CPCs_Mouse1.59190307
46* CBX2_27304074_Chip-Seq_ESCs_Mouse1.52310712
47* RNF2_27304074_Chip-Seq_ESCs_Mouse1.50925186
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50810137
49AR_21572438_ChIP-Seq_LNCaP_Human1.49743717
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48417640
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.46353201
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.46353201
53* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45483949
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.43929320
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41644608
56* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37936010
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.37705021
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.36211242
59* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.36030764
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35889202
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35694030
62CLOCK_20551151_ChIP-Seq_293T_Human1.34122204
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30179327
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.29614116
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29540029
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29475671
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26260562
68* SA1_22415368_ChIP-Seq_MEFs_Mouse1.26203121
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.25930247
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24549861
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24499564
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22904550
73* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21865201
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20027851
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.19138104
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18786994
77EWS_26573619_Chip-Seq_HEK293_Human1.15088526
78GBX2_23144817_ChIP-Seq_PC3_Human1.14524960
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14404691
80EZH2_22144423_ChIP-Seq_EOC_Human1.13589467
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13260325
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13254308
83ZNF274_21170338_ChIP-Seq_K562_Hela1.12974697
84PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11632923
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11589438
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11589438
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11392144
88* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11234927
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.09485716
90FUS_26573619_Chip-Seq_HEK293_Human1.08886707
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07914575
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07583374
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06214997
94* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06129794
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06012241
96* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05953483
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05487498
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05134339
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03599041
100* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02781574
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02213649
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.01597859
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01073354
104* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99149442
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98986077
106* RING1B_27294783_Chip-Seq_ESCs_Mouse0.97219322
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97121120
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96736145
109* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96366579
110* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96271673
111AHR_22903824_ChIP-Seq_MCF-7_Human0.95999963
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95695368
113* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94719489
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92295939
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92059381
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91586920
117TP53_23651856_ChIP-Seq_MEFs_Mouse0.91354961
118* NFI_21473784_ChIP-Seq_ESCs_Mouse0.91242837
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90942348
120* BCAT_22108803_ChIP-Seq_LS180_Human0.90529814
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.90506767
122* RXR_22108803_ChIP-Seq_LS180_Human0.90281496
123DROSHA_22980978_ChIP-Seq_HELA_Human0.90068428
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89720232
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89494553
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89214634
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88480772
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86810298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.46232756
2MP0005503_abnormal_tendon_morphology5.42385994
3MP0005275_abnormal_skin_tensile4.09358865
4MP0010030_abnormal_orbit_morphology3.23199545
5MP0003385_abnormal_body_wall2.88195473
6MP0003705_abnormal_hypodermis_morpholog2.86058475
7* MP0009250_abnormal_appendicular_skeleto2.81236545
8MP0003279_aneurysm2.79015482
9MP0009384_cardiac_valve_regurgitation2.75685046
10MP0009053_abnormal_anal_canal2.70707098
11MP0005508_abnormal_skeleton_morphology2.31044645
12MP0001958_emphysema2.23427243
13MP0005257_abnormal_intraocular_pressure2.19684363
14MP0004272_abnormal_basement_membrane2.13746995
15MP0003942_abnormal_urinary_system2.10900740
16MP0001299_abnormal_eye_distance/2.04084013
17* MP0000049_abnormal_middle_ear2.03022658
18MP0002249_abnormal_larynx_morphology1.98912991
19* MP0003937_abnormal_limbs/digits/tail_de1.93747242
20MP0000428_abnormal_craniofacial_morphol1.91450396
21* MP0003755_abnormal_palate_morphology1.89775406
22MP0003122_maternal_imprinting1.87458605
23MP0006054_spinal_hemorrhage1.87141517
24MP0005623_abnormal_meninges_morphology1.86742967
25MP0000733_abnormal_muscle_development1.84554057
26MP0000534_abnormal_ureter_morphology1.82819309
27MP0002932_abnormal_joint_morphology1.76580112
28MP0002108_abnormal_muscle_morphology1.76388833
29MP0000762_abnormal_tongue_morphology1.71541136
30MP0003950_abnormal_plasma_membrane1.70695467
31MP0002282_abnormal_trachea_morphology1.70178813
32MP0002938_white_spotting1.69453393
33MP0000749_muscle_degeneration1.64037669
34MP0002896_abnormal_bone_mineralization1.62275993
35MP0003941_abnormal_skin_development1.58871585
36MP0000566_synostosis1.58075707
37MP0009780_abnormal_chondrocyte_physiolo1.53349819
38MP0000013_abnormal_adipose_tissue1.52387648
39* MP0002115_abnormal_skeleton_extremities1.52352058
40* MP0003935_abnormal_craniofacial_develop1.51587957
41* MP0000163_abnormal_cartilage_morphology1.50324199
42MP0002060_abnormal_skin_morphology1.45178844
43MP0002233_abnormal_nose_morphology1.44749674
44* MP0002109_abnormal_limb_morphology1.42747007
45* MP0002116_abnormal_craniofacial_bone1.41767652
46MP0004134_abnormal_chest_morphology1.38591508
47MP0000537_abnormal_urethra_morphology1.36548892
48* MP0000432_abnormal_head_morphology1.36105103
49* MP0002113_abnormal_skeleton_development1.30200782
50MP0002295_abnormal_pulmonary_circulatio1.29964445
51MP0005171_absent_coat_pigmentation1.27766224
52MP0003091_abnormal_cell_migration1.27287786
53MP0005023_abnormal_wound_healing1.25852207
54MP0004858_abnormal_nervous_system1.25264023
55MP0000767_abnormal_smooth_muscle1.24436960
56MP0010352_gastrointestinal_tract_polyps1.21345385
57MP0005595_abnormal_vascular_smooth1.21131216
58MP0004084_abnormal_cardiac_muscle1.18672429
59MP0005248_abnormal_Harderian_gland1.17943969
60MP0003115_abnormal_respiratory_system1.14517655
61MP0005367_renal/urinary_system_phenotyp1.14330682
62MP0000516_abnormal_urinary_system1.14330682
63* MP0002177_abnormal_outer_ear1.14241865
64MP0004036_abnormal_muscle_relaxation1.14000441
65MP0005390_skeleton_phenotype1.11970843
66MP0001293_anophthalmia1.10985872
67MP0001243_abnormal_dermal_layer1.09966098
68MP0005369_muscle_phenotype1.08483789
69MP0005076_abnormal_cell_differentiation1.07862719
70MP0003123_paternal_imprinting1.06277737
71MP0001346_abnormal_lacrimal_gland1.04654638
72MP0003566_abnormal_cell_adhesion1.01769891
73* MP0002114_abnormal_axial_skeleton1.00780102
74MP0004087_abnormal_muscle_fiber1.00562140
75MP0001542_abnormal_bone_strength1.00009237
76MP0002111_abnormal_tail_morphology0.99975588
77MP0003121_genomic_imprinting0.95388499
78MP0010386_abnormal_urinary_bladder0.94400820
79MP0003938_abnormal_ear_development0.94384097
80MP0002089_abnormal_postnatal_growth/wei0.93815359
81MP0005620_abnormal_muscle_contractility0.92508010
82MP0000747_muscle_weakness0.92215563
83MP0002168_other_aberrant_phenotype0.90810686
84MP0000003_abnormal_adipose_tissue0.89989953
85MP0005187_abnormal_penis_morphology0.88413988
86MP0010368_abnormal_lymphatic_system0.87618028
87MP0002933_joint_inflammation0.86541371
88* MP0001340_abnormal_eyelid_morphology0.84859573
89MP0000613_abnormal_salivary_gland0.83728518
90MP0005388_respiratory_system_phenotype0.83006821
91MP0002133_abnormal_respiratory_system0.83006821
92MP0002092_abnormal_eye_morphology0.82258587
93MP0002106_abnormal_muscle_physiology0.80998234
94MP0002998_abnormal_bone_remodeling0.80938779
95MP0009703_decreased_birth_body0.80091260
96MP0009379_abnormal_foot_pigmentation0.77809113
97MP0001879_abnormal_lymphatic_vessel0.76597918
98MP0005164_abnormal_response_to0.75903659
99MP0003283_abnormal_digestive_organ0.74930551
100MP0006138_congestive_heart_failure0.74385340
101MP0003045_fibrosis0.74335340
102MP0002697_abnormal_eye_size0.73664502
103* MP0002925_abnormal_cardiovascular_devel0.73462557
104MP0004197_abnormal_fetal_growth/weight/0.72947051
105MP0002128_abnormal_blood_circulation0.72247081
106MP0003567_abnormal_fetal_cardiomyocyte0.72245465
107MP0000759_abnormal_skeletal_muscle0.71302000
108* MP0001175_abnormal_lung_morphology0.70784796
109MP0004233_abnormal_muscle_weight0.70743438
110MP0000579_abnormal_nail_morphology0.70660929
111MP0002269_muscular_atrophy0.69700892
112MP0000569_abnormal_digit_pigmentation0.68239417
113MP0004130_abnormal_muscle_cell0.68207290
114MP0001348_abnormal_lacrimal_gland0.68179148
115MP0005670_abnormal_white_adipose0.67948116
116MP0001849_ear_inflammation0.67751478
117* MP0003795_abnormal_bone_structure0.67070650
118MP0001286_abnormal_eye_development0.66936947
119MP0005197_abnormal_uvea_morphology0.66661809
120* MP0001614_abnormal_blood_vessel0.66321958
121MP0004510_myositis0.65750286
122MP0004145_abnormal_muscle_electrophysio0.65427977
123MP0000750_abnormal_muscle_regeneration0.65031004
124MP0000751_myopathy0.62819671
125MP0000462_abnormal_digestive_system0.62412225
126* MP0001270_distended_abdomen0.61372134
127MP0005375_adipose_tissue_phenotype0.59860214
128MP0005330_cardiomyopathy0.59693520
129MP0003828_pulmonary_edema0.59424165
130MP0005165_increased_susceptibility_to0.58120460
131MP0001177_atelectasis0.56990839
132MP0003448_altered_tumor_morphology0.55688460
133MP0002877_abnormal_melanocyte_morpholog0.52800578

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.69119505
2Premature rupture of membranes (HP:0001788)6.11721744
3Shallow orbits (HP:0000586)4.97575638
4Short 4th metacarpal (HP:0010044)4.92543427
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.92543427
6Abnormality of the 4th metacarpal (HP:0010012)4.01988886
7Aortic dissection (HP:0002647)3.84853234
8Broad metatarsal (HP:0001783)3.82014865
9Ankle contracture (HP:0006466)3.78449101
10Soft skin (HP:0000977)3.59892356
11Syringomyelia (HP:0003396)3.46602436
12Spinal cord lesions (HP:0100561)3.46602436
13Neonatal short-limb short stature (HP:0008921)3.32272729
14Mesomelia (HP:0003027)3.31891779
15Cervical subluxation (HP:0003308)3.31583305
16Peritonitis (HP:0002586)3.31215217
17Arterial tortuosity (HP:0005116)3.29947899
18Atrophic scars (HP:0001075)3.26646789
19Abnormality of dentin (HP:0010299)3.18163504
20Abnormality of skeletal muscle fiber size (HP:0012084)3.10145718
21Bladder diverticulum (HP:0000015)3.07805794
22Coronal craniosynostosis (HP:0004440)3.02960072
23Follicular hyperkeratosis (HP:0007502)3.02309130
24Dilatation of the ascending aorta (HP:0005111)3.01387656
25Type 1 muscle fiber predominance (HP:0003803)2.93791069
26Wide anterior fontanel (HP:0000260)2.92855520
27Aortic aneurysm (HP:0004942)2.92200961
28Mitral valve prolapse (HP:0001634)2.89568575
29Bell-shaped thorax (HP:0001591)2.89247401
30Fragile skin (HP:0001030)2.82327810
31Genu recurvatum (HP:0002816)2.81234946
32Abnormality of the parietal bone (HP:0002696)2.78828570
33Abnormality of the phalanges of the hallux (HP:0010057)2.75595349
34Aortic regurgitation (HP:0001659)2.71018964
35Biconcave vertebral bodies (HP:0004586)2.70371541
36Deviation of the hallux (HP:0010051)2.68009010
37Wormian bones (HP:0002645)2.66900428
38Blue sclerae (HP:0000592)2.61425870
39Wrist flexion contracture (HP:0001239)2.60297914
40Short middle phalanx of the 5th finger (HP:0004220)2.55236445
41Mild short stature (HP:0003502)2.53146880
42Broad toe (HP:0001837)2.51653767
43Buphthalmos (HP:0000557)2.50862414
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.50470468
45Hallux valgus (HP:0001822)2.49905225
46Nemaline bodies (HP:0003798)2.49632101
47Cerebral aneurysm (HP:0004944)2.48763144
48Asymmetry of the thorax (HP:0001555)2.46975641
49Infantile muscular hypotonia (HP:0008947)2.45577156
50Calcaneovalgus deformity (HP:0001848)2.44143158
51Spinal rigidity (HP:0003306)2.42841286
52Muscle fiber inclusion bodies (HP:0100299)2.42569342
53Deformed tarsal bones (HP:0008119)2.38998561
54Broad long bones (HP:0005622)2.38625258
55Absent frontal sinuses (HP:0002688)2.37304588
56Vertebral compression fractures (HP:0002953)2.37122816
57Abnormality of the 2nd finger (HP:0004100)2.34816506
58Elbow flexion contracture (HP:0002987)2.32620760
59Hypoventilation (HP:0002791)2.28799820
60Slender build (HP:0001533)2.26021859
61Hyperextensible skin (HP:0000974)2.24732725
62Broad hallux (HP:0010055)2.23131811
63Aneurysm (HP:0002617)2.20733282
64Morphological abnormality of the middle ear (HP:0008609)2.19827683
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19121439
66Joint laxity (HP:0001388)2.18039051
67Aortic valve stenosis (HP:0001650)2.16431661
68Ulnar deviation of the wrist (HP:0003049)2.16313377
69Ulnar bowing (HP:0003031)2.16142205
70Mitral stenosis (HP:0001718)2.12527619
71Bowel diverticulosis (HP:0005222)2.12121486
72Overgrowth (HP:0001548)2.11835871
73Hypoplastic ischia (HP:0003175)2.09558172
74Mitral regurgitation (HP:0001653)2.09504451
75Cutaneous finger syndactyly (HP:0010554)2.07352210
76Short clavicles (HP:0000894)2.07268169
77Knee flexion contracture (HP:0006380)2.07262136
78Osteoarthritis (HP:0002758)2.06262105
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05712570
80Vascular tortuosity (HP:0004948)2.03936281
81Broad phalanx (HP:0006009)2.03677888
82Hypoplasia of the iris (HP:0007676)2.03374793
83Broad ribs (HP:0000885)2.02431409
84Distal arthrogryposis (HP:0005684)2.02262243
85Delayed cranial suture closure (HP:0000270)2.00752704
86Joint stiffness (HP:0001387)2.00342134
87Persistence of primary teeth (HP:0006335)2.00271970
88Abnormality of the distal phalanx of the thumb (HP:0009617)1.97699523
89Midline defect of the nose (HP:0004122)1.96872252
90Decreased skull ossification (HP:0004331)1.96484699
91Abnormal delivery (HP:0001787)1.96216453
92Spondylolisthesis (HP:0003302)1.95709638
93Turricephaly (HP:0000262)1.94640430
94Limb-girdle muscle weakness (HP:0003325)1.94277402
95Hypoplasia of the maxilla (HP:0000327)1.92612671
96Increased number of teeth (HP:0011069)1.92480409
97Broad thumb (HP:0011304)1.92012157
98Aplasia/Hypoplasia of the clavicles (HP:0006710)1.91910473
99Narrow palate (HP:0000189)1.91653019
100Dislocated radial head (HP:0003083)1.90888447
101Camptodactyly of toe (HP:0001836)1.89531003
102Mildly elevated creatine phosphokinase (HP:0008180)1.87635994
103Limited hip movement (HP:0008800)1.87391779
104Venous abnormality (HP:0002624)1.87377029
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87350422
106Cupped ribs (HP:0000887)1.87154987
107Increased connective tissue (HP:0009025)1.86597882
108Renal duplication (HP:0000075)1.86475791
109Hip contracture (HP:0003273)1.86150151
110Generalized amyotrophy (HP:0003700)1.85807812
111Short 5th finger (HP:0009237)1.85475693
112Flared iliac wings (HP:0002869)1.84628459
113Striae distensae (HP:0001065)1.84349126
114Increased variability in muscle fiber diameter (HP:0003557)1.84316264
115* Microglossia (HP:0000171)1.83875453
116Abnormality of the radial head (HP:0003995)1.83097172
117Wide cranial sutures (HP:0010537)1.82465652
118Abnormality of the ischium (HP:0003174)1.82065928
119Thin bony cortex (HP:0002753)1.81644266
120Trigonocephaly (HP:0000243)1.81152782
121Delayed closure of the anterior fontanelle (HP:0001476)1.80240507
122Round ear (HP:0100830)1.80061270
123Tibial bowing (HP:0002982)1.79402947
124Abnormality of skull ossification (HP:0002703)1.79162512
125Breech presentation (HP:0001623)1.78368689
126Flat cornea (HP:0007720)1.78353600
127Abnormality of the acetabulum (HP:0003170)1.78001171
128Pulmonary artery stenosis (HP:0004415)1.76775580
129Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.76590411
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.76455483
131Osteolytic defects of the hand bones (HP:0009699)1.76455483
132Ectopia lentis (HP:0001083)1.76391476
133Protruding ear (HP:0000411)1.76210854
134Venous insufficiency (HP:0005293)1.75676848
135Inguinal hernia (HP:0000023)1.74646017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR26.50230344
2EPHA34.65849647
3LATS14.51911462
4MYLK3.81946953
5PDGFRA3.73916298
6TTN3.68510749
7SIK13.24506471
8LATS22.70699530
9EPHB22.65458510
10TRIB32.17021300
11AKT32.07439528
12DMPK2.06868784
13NTRK12.05118488
14STK31.85593066
15PAK21.82236742
16FGFR21.68999376
17PIK3CA1.65071012
18FGFR11.64900154
19FER1.54507400
20NEK91.54265028
21TESK11.54099105
22MKNK11.51664381
23MAPK71.40860569
24PRKD21.35399402
25BMX1.32489414
26FRK1.30771267
27TRPM71.28659521
28ERBB31.28641464
29CAMK1D1.27795270
30NUAK11.26757580
31PDGFRB1.26633266
32PAK31.23585103
33RPS6KA41.23227184
34MAP3K61.21674282
35WNK11.15228882
36EPHB11.15219140
37PTK21.14400186
38CAMK1G1.12292404
39ROCK11.10702072
40RIPK11.09254380
41FGFR41.07638367
42TGFBR21.04370647
43MTOR1.03266923
44PAK61.02319113
45CDK120.98537390
46MET0.98192808
47MKNK20.97644088
48STK38L0.93963570
49PKN20.92889969
50CASK0.91096152
51MAP3K70.91089298
52ERBB40.88098560
53PHKG20.87724702
54PHKG10.87724702
55PTK60.86987350
56ADRBK10.85075298
57PLK20.82389402
58PTK2B0.80708374
59EIF2AK20.78569213
60MAP3K100.77683048
61MARK10.75699344
62MAPK120.75541683
63PAK40.71680598
64CLK10.71648256
65NLK0.69558847
66RPS6KA20.69508265
67STK380.69333048
68CDK80.69304733
69MAP3K30.68651675
70CDK60.67499221
71ROCK20.65142327
72MAPKAPK30.64902889
73FLT30.64518952
74FGFR30.63268698
75INSR0.62405802
76PRKD10.61500805
77LRRK20.60072612
78CAMK2G0.59599496
79CSNK1A1L0.58702388
80PIK3CG0.58336232
81MAP2K10.57364935
82ERBB20.55162081
83MOS0.54767330
84TYK20.53973662
85MAP2K30.51770673
86MARK20.51594733
87LMTK20.51561154
88RET0.49057241
89TIE10.48752354
90KSR20.48317329
91MAPK40.47633866
92MELK0.47378096
93DYRK1B0.46476824
94ZAK0.46129854
95ILK0.44736154
96LIMK10.44692053
97CSNK1G10.44684746
98RPS6KC10.44359894
99RPS6KL10.44359894
100MAPK10.42394582
101CAMK2D0.41857909
102TLK10.41178450
103CDK70.40822834
104CDC42BPA0.40059822
105SGK30.37946990
106EEF2K0.37741919
107TGFBR10.36354623
108PRKCE0.35746118
109PRKCH0.35561978
110SRC0.35299441
111PLK30.34822511
112MAPK110.34565974
113HIPK20.34413040
114PRKG10.33784721
115CDK90.33635490
116JAK10.33248621
117ICK0.33216545
118CAMK2B0.32809874
119PRKAA20.32787037
120ERN10.32762939
121PRKG20.32081060
122IGF1R0.31913933
123RPS6KA60.31845123
124JAK30.31297461
125MAPKAPK50.30774952
126TYRO30.30704037
127BRD40.30681104
128MAPKAPK20.28976633
129DAPK30.28746670
130PRKD30.28020800
131AKT10.27686096
132OBSCN0.25673749
133PIM20.22346807
134KIT0.22165379
135MAPK80.22112433
136ABL10.21531016
137MAPK140.18608848
138CSF1R0.18296632
139TAOK20.18228955
140PAK10.16604290
141ABL20.16534918
142CHUK0.16223385
143GSK3A0.15776722
144CDK10.14928090

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.70540972
2Basal cell carcinoma_Homo sapiens_hsa052173.45029458
3Focal adhesion_Homo sapiens_hsa045102.81075408
4Hedgehog signaling pathway_Homo sapiens_hsa043402.69727517
5Adherens junction_Homo sapiens_hsa045202.54429631
6Proteoglycans in cancer_Homo sapiens_hsa052052.49812767
7TGF-beta signaling pathway_Homo sapiens_hsa043502.39317969
8Hippo signaling pathway_Homo sapiens_hsa043902.35934607
9Protein digestion and absorption_Homo sapiens_hsa049742.28318387
10MicroRNAs in cancer_Homo sapiens_hsa052062.20838487
11Wnt signaling pathway_Homo sapiens_hsa043102.09784236
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04231365
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98412740
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.92317327
15Melanoma_Homo sapiens_hsa052181.92141677
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85676171
17Dilated cardiomyopathy_Homo sapiens_hsa054141.84560981
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79823405
19Axon guidance_Homo sapiens_hsa043601.79292048
20Malaria_Homo sapiens_hsa051441.79005825
21Prostate cancer_Homo sapiens_hsa052151.74416338
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71649715
23Amoebiasis_Homo sapiens_hsa051461.67528623
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.66703402
25Small cell lung cancer_Homo sapiens_hsa052221.63502494
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58635082
27Bladder cancer_Homo sapiens_hsa052191.49450836
28Pathways in cancer_Homo sapiens_hsa052001.48025126
29Chronic myeloid leukemia_Homo sapiens_hsa052201.43679003
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.41799776
31p53 signaling pathway_Homo sapiens_hsa041151.40583330
32Melanogenesis_Homo sapiens_hsa049161.37470547
33Viral myocarditis_Homo sapiens_hsa054161.36418878
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34419536
35Renin-angiotensin system_Homo sapiens_hsa046141.27114395
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22359454
37HTLV-I infection_Homo sapiens_hsa051661.19395861
38Colorectal cancer_Homo sapiens_hsa052101.17189347
39Glioma_Homo sapiens_hsa052141.15508023
40Rap1 signaling pathway_Homo sapiens_hsa040151.14738179
41Cell cycle_Homo sapiens_hsa041101.04511248
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04078542
43Tight junction_Homo sapiens_hsa045301.03131339
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01761479
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00558024
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99925213
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.97460282
48Pancreatic cancer_Homo sapiens_hsa052120.97186299
49Circadian rhythm_Homo sapiens_hsa047100.95325704
50Platelet activation_Homo sapiens_hsa046110.92339647
51Dorso-ventral axis formation_Homo sapiens_hsa043200.91743896
52Thyroid cancer_Homo sapiens_hsa052160.88216318
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85511036
54Calcium signaling pathway_Homo sapiens_hsa040200.85223766
55Renal cell carcinoma_Homo sapiens_hsa052110.84637713
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84184012
57Endometrial cancer_Homo sapiens_hsa052130.83608118
58Prion diseases_Homo sapiens_hsa050200.82603401
59Gap junction_Homo sapiens_hsa045400.79143580
60Hepatitis B_Homo sapiens_hsa051610.76272652
61Ras signaling pathway_Homo sapiens_hsa040140.76154003
62Notch signaling pathway_Homo sapiens_hsa043300.75554927
63Complement and coagulation cascades_Homo sapiens_hsa046100.74761207
64TNF signaling pathway_Homo sapiens_hsa046680.74758490
65Viral carcinogenesis_Homo sapiens_hsa052030.70904537
66Lysine degradation_Homo sapiens_hsa003100.69116472
67Shigellosis_Homo sapiens_hsa051310.68434860
68Ovarian steroidogenesis_Homo sapiens_hsa049130.67169914
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66290762
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.65555792
71Pertussis_Homo sapiens_hsa051330.65468060
72FoxO signaling pathway_Homo sapiens_hsa040680.65456223
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65258565
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63268209
75Gastric acid secretion_Homo sapiens_hsa049710.62463049
76MAPK signaling pathway_Homo sapiens_hsa040100.61209876
77Other glycan degradation_Homo sapiens_hsa005110.60511821
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.60247648
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59941753
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59880777
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59248887
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.57615971
83Cocaine addiction_Homo sapiens_hsa050300.56378882
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.55931563
85Glucagon signaling pathway_Homo sapiens_hsa049220.54973939
86Toxoplasmosis_Homo sapiens_hsa051450.54814294
87Estrogen signaling pathway_Homo sapiens_hsa049150.53660230
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51566771
89mTOR signaling pathway_Homo sapiens_hsa041500.51375391
90VEGF signaling pathway_Homo sapiens_hsa043700.51208403
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49873047
92Salmonella infection_Homo sapiens_hsa051320.49581296
93ErbB signaling pathway_Homo sapiens_hsa040120.49491198
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48825593
95Cholinergic synapse_Homo sapiens_hsa047250.48582438
96Prolactin signaling pathway_Homo sapiens_hsa049170.48217176
97GnRH signaling pathway_Homo sapiens_hsa049120.47354572
98Salivary secretion_Homo sapiens_hsa049700.47199460
99Circadian entrainment_Homo sapiens_hsa047130.46580706
100Insulin secretion_Homo sapiens_hsa049110.45930940
101AMPK signaling pathway_Homo sapiens_hsa041520.45630269
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45178020
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44157115
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.44000752
105PPAR signaling pathway_Homo sapiens_hsa033200.42421397
106HIF-1 signaling pathway_Homo sapiens_hsa040660.42229523
107Endocytosis_Homo sapiens_hsa041440.41449573
108Renin secretion_Homo sapiens_hsa049240.39972060
109cAMP signaling pathway_Homo sapiens_hsa040240.39943301
110Non-small cell lung cancer_Homo sapiens_hsa052230.38140260
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37529326
112Choline metabolism in cancer_Homo sapiens_hsa052310.37129137
113Insulin resistance_Homo sapiens_hsa049310.35341521
114Thyroid hormone synthesis_Homo sapiens_hsa049180.35048168
115Phagosome_Homo sapiens_hsa041450.34728105
116N-Glycan biosynthesis_Homo sapiens_hsa005100.34622439
117Systemic lupus erythematosus_Homo sapiens_hsa053220.34256071
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33763314
119Oxytocin signaling pathway_Homo sapiens_hsa049210.33685153
120Acute myeloid leukemia_Homo sapiens_hsa052210.32222214
121Insulin signaling pathway_Homo sapiens_hsa049100.31487205

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