PRRX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)6.11622057
2virion attachment to host cell (GO:0019062)6.11622057
3chondrocyte proliferation (GO:0035988)6.07647473
4collagen fibril organization (GO:0030199)5.87211223
5type B pancreatic cell proliferation (GO:0044342)5.86578597
6protein heterotrimerization (GO:0070208)5.79854385
7outer ear morphogenesis (GO:0042473)5.45010172
8bone trabecula formation (GO:0060346)5.32564747
9adhesion of symbiont to host (GO:0044406)5.26336874
10tooth mineralization (GO:0034505)5.05041158
11sequestering of extracellular ligand from receptor (GO:0035581)4.97309706
12extracellular matrix assembly (GO:0085029)4.92204649
13skin morphogenesis (GO:0043589)4.41357124
14endodermal cell differentiation (GO:0035987)4.40948420
15neuron projection extension involved in neuron projection guidance (GO:1902284)4.34592573
16axon extension involved in axon guidance (GO:0048846)4.34592573
17mesenchymal-epithelial cell signaling (GO:0060638)4.29456800
18metanephric mesenchyme development (GO:0072075)4.22226449
19planar cell polarity pathway involved in neural tube closure (GO:0090179)4.19871194
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.13236245
21craniofacial suture morphogenesis (GO:0097094)4.12357637
22negative regulation of smooth muscle cell migration (GO:0014912)4.09705254
23cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.09198035
24kidney mesenchyme development (GO:0072074)4.02255861
25blood vessel maturation (GO:0001955)3.96300338
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.93359982
27cellular response to vitamin (GO:0071295)3.91827783
28paraxial mesoderm development (GO:0048339)3.91797645
29fibril organization (GO:0097435)3.90403383
30positive regulation of epithelial to mesenchymal transition (GO:0010718)3.88716222
31* middle ear morphogenesis (GO:0042474)3.86088354
32embryonic skeletal joint morphogenesis (GO:0060272)3.85889685
33protein retention in ER lumen (GO:0006621)3.81474708
34positive regulation of endothelial cell apoptotic process (GO:2000353)3.76308838
35cranial suture morphogenesis (GO:0060363)3.69444180
36barbed-end actin filament capping (GO:0051016)3.69157111
37regulation of heart morphogenesis (GO:2000826)3.59367908
38collagen metabolic process (GO:0032963)3.56748156
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.55429013
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54163695
41negative regulation of fatty acid transport (GO:2000192)3.53794410
42wound healing, spreading of epidermal cells (GO:0035313)3.53512781
43negative regulation of embryonic development (GO:0045992)3.52537106
44endocardial cushion development (GO:0003197)3.50533614
45* embryonic cranial skeleton morphogenesis (GO:0048701)3.48004980
46negative regulation of chondrocyte differentiation (GO:0032331)3.47133057
47regulation of plasminogen activation (GO:0010755)3.46832361
48cell migration involved in heart development (GO:0060973)3.45541974
49regulation of tight junction assembly (GO:2000810)3.43860470
50vascular endothelial growth factor signaling pathway (GO:0038084)3.43841695
51negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.43773841
52keratan sulfate catabolic process (GO:0042340)3.43139583
53hyaluronan catabolic process (GO:0030214)3.42721425
54hippo signaling (GO:0035329)3.40662490
55collagen catabolic process (GO:0030574)3.39314127
56mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.38465330
57cell adhesion mediated by integrin (GO:0033627)3.38458023
58stress fiber assembly (GO:0043149)3.31613484
59negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.30766268
60multicellular organismal macromolecule metabolic process (GO:0044259)3.28712859
61heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.27638398
62substrate-dependent cell migration (GO:0006929)3.24600121
63cartilage morphogenesis (GO:0060536)3.23051417
64mesenchymal cell proliferation (GO:0010463)3.22750638
65negative regulation of leukocyte chemotaxis (GO:0002689)3.22727435
66negative regulation of BMP signaling pathway (GO:0030514)3.20491136
67extracellular matrix organization (GO:0030198)3.20118506
68extracellular structure organization (GO:0043062)3.19133163
69glomerular basement membrane development (GO:0032836)3.18437352
70cell proliferation involved in metanephros development (GO:0072203)3.16802214
71viral transcription (GO:0019083)3.16062098
72organ induction (GO:0001759)3.15090823
73cellular response to vitamin D (GO:0071305)3.14720529
74cellular response to amino acid stimulus (GO:0071230)3.14667670
75cell migration involved in sprouting angiogenesis (GO:0002042)3.13265788
76dermatan sulfate biosynthetic process (GO:0030208)3.11130459
77endothelial cell morphogenesis (GO:0001886)3.09193512
78polarized epithelial cell differentiation (GO:0030859)3.08715786
79translational termination (GO:0006415)3.07771039
80multicellular organismal metabolic process (GO:0044236)3.07226422
81negative regulation of osteoblast proliferation (GO:0033689)3.06362536
82multicellular organismal catabolic process (GO:0044243)3.06093377
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04854030
84negative regulation of cartilage development (GO:0061037)2.99500469
85negative regulation of DNA repair (GO:0045738)2.99014791
86peptidyl-proline hydroxylation (GO:0019511)2.98816826
87epithelial cell-cell adhesion (GO:0090136)2.96290430
88embryonic forelimb morphogenesis (GO:0035115)2.94295479
89proximal/distal pattern formation (GO:0009954)2.93292786
90pattern specification involved in kidney development (GO:0061004)2.92155339
91basement membrane organization (GO:0071711)2.91988862
92plasma membrane repair (GO:0001778)2.91695568
93trabecula formation (GO:0060343)2.91184683
94mesenchyme development (GO:0060485)2.90682048
95extracellular matrix disassembly (GO:0022617)2.89365112
96cell-substrate junction assembly (GO:0007044)2.89252460
97cochlea morphogenesis (GO:0090103)2.89029004
98negative regulation of catenin import into nucleus (GO:0035414)2.88885717
99protein localization to cell surface (GO:0034394)2.86979764
100apoptotic cell clearance (GO:0043277)2.86965669
101Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.86756223
102positive regulation of cartilage development (GO:0061036)2.86158478
103wound healing, spreading of cells (GO:0044319)2.85520558
104negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.83038069
105regulation of cartilage development (GO:0061035)2.81369439
106epithelial to mesenchymal transition (GO:0001837)2.81251639
107Golgi transport vesicle coating (GO:0048200)2.81212281
108COPI coating of Golgi vesicle (GO:0048205)2.81212281
109regulation of integrin-mediated signaling pathway (GO:2001044)2.81194000
110peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.81004562
111positive regulation of fibroblast migration (GO:0010763)2.80883270
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80879193
113positive regulation of stem cell differentiation (GO:2000738)2.80520478
114chondrocyte development (GO:0002063)2.80186663
115dermatan sulfate metabolic process (GO:0030205)2.80122601
116notochord development (GO:0030903)2.79689956
117positive regulation of blood vessel endothelial cell migration (GO:0043536)2.76971214
118regulation of establishment of planar polarity (GO:0090175)2.76406570
119regulation of epithelial to mesenchymal transition (GO:0010717)2.74231031
120mesenchyme morphogenesis (GO:0072132)2.73794618
121heparan sulfate proteoglycan metabolic process (GO:0030201)2.73363056
122positive regulation of osteoblast proliferation (GO:0033690)2.73310182
123face morphogenesis (GO:0060325)2.72622964
124regulation of gastrulation (GO:0010470)2.71897501
125embryonic camera-type eye development (GO:0031076)2.71475266
126vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71264008
127regulation of cell aging (GO:0090342)2.70927721
128protein hydroxylation (GO:0018126)2.70562548
129venous blood vessel morphogenesis (GO:0048845)2.69164639
130regulation of cellular senescence (GO:2000772)2.68734354
131regulation of extracellular matrix disassembly (GO:0010715)2.67546263
132extracellular fibril organization (GO:0043206)2.66649359
133negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.66374439
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.64601353
135negative regulation of nitric-oxide synthase activity (GO:0051001)2.64524315
136cell proliferation involved in kidney development (GO:0072111)2.64516926
137body morphogenesis (GO:0010171)2.64505020
138cell-substrate adherens junction assembly (GO:0007045)2.63852832
139focal adhesion assembly (GO:0048041)2.63852832
140translational elongation (GO:0006414)2.63631030
141extracellular regulation of signal transduction (GO:1900115)2.61964559
142extracellular negative regulation of signal transduction (GO:1900116)2.61964559
143forelimb morphogenesis (GO:0035136)2.61358134
144regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.61282571
145regulation of SMAD protein import into nucleus (GO:0060390)2.58737262
146regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.57202211
147regulation of mitotic spindle organization (GO:0060236)2.57014319
148cardiac myofibril assembly (GO:0055003)2.55682931
149adherens junction assembly (GO:0034333)2.54627320
150regulation of organ formation (GO:0003156)2.54076253
151eyelid development in camera-type eye (GO:0061029)2.53916618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.43822345
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.62920158
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.19435637
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.35631273
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.06486714
6* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.05620519
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97100095
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91597573
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62132050
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60955383
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57572895
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51033223
13CLOCK_20551151_ChIP-Seq_293T_Human2.48249627
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.48209739
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.40539987
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.35158352
17* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.33040312
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26276358
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.20427469
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.19860473
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.19255150
22ELK3_25401928_ChIP-Seq_HUVEC_Human2.16425125
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15991302
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12947734
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.09042637
26TP53_20018659_ChIP-ChIP_R1E_Mouse2.02789146
27BRD4_25478319_ChIP-Seq_HGPS_Human2.01489568
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.98226146
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97843561
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92183333
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89954990
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89386674
33* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89291409
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79475871
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76861568
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76495627
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76495627
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74747102
39E2F7_22180533_ChIP-Seq_HELA_Human1.70167503
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.65857110
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65483189
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65280543
43ATF3_27146783_Chip-Seq_COLON_Human1.56898356
44TP53_22127205_ChIP-Seq_IMR90_Human1.56576566
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56349238
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56068030
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55546571
48KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55530889
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54718284
50SMC1_22415368_ChIP-Seq_MEFs_Mouse1.54508368
51CJUN_26792858_Chip-Seq_BT549_Human1.54196282
52ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51726065
53* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50268187
54XRN2_22483619_ChIP-Seq_HELA_Human1.46823364
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43962666
56* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42784007
57AR_21909140_ChIP-Seq_LNCAP_Human1.39947009
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39754877
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38795714
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.38678405
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.37529724
62MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36003548
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35410864
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34670634
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34670634
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.34480653
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34284545
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.33639645
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.33238932
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32627068
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32579533
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32129426
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28049446
74ZNF263_19887448_ChIP-Seq_K562_Human1.27533078
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27277582
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26893939
77* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26423984
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25762833
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24774809
80RACK7_27058665_Chip-Seq_MCF-7_Human1.23942727
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23761281
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23649355
83* KDM2B_26808549_Chip-Seq_K562_Human1.23467897
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22521505
85SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21889064
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21388915
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.21297506
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.20582222
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20387111
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20033643
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.19270985
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.19241651
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.19106307
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.18015548
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17051459
96SA1_27219007_Chip-Seq_ERYTHROID_Human1.16030131
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15863104
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15701513
99TP53_18474530_ChIP-ChIP_U2OS_Human1.14895565
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14504914
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12683671
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11980599
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.11293485
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10919748
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10407578
106CTCF_27219007_Chip-Seq_Bcells_Human1.10304602
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09891368
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08956488
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08803860
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08046937
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06357418
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.06136936
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05903926
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04249156
115KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03887547
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03873214
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.02594348
118* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02476418
119STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00330724
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00256406
121CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00092565
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99903555
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99819924
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99477029
125KDM2B_26808549_Chip-Seq_DND41_Human0.99088324
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98351844
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.97856557
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.97856557
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97558714
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97554380
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.97334633
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97239782
133SA1_22415368_ChIP-Seq_MEFs_Mouse0.96741378
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95623021
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95242694
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95242694
137LXR_22292898_ChIP-Seq_THP-1_Human0.94923795
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93362514
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93123287
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92704022
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91153347
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91153347
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91153347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.65816460
2MP0005503_abnormal_tendon_morphology4.78366968
3MP0003705_abnormal_hypodermis_morpholog3.95421624
4MP0005275_abnormal_skin_tensile3.90316731
5MP0010030_abnormal_orbit_morphology3.52528559
6MP0003279_aneurysm3.47275660
7MP0005623_abnormal_meninges_morphology2.78861289
8MP0009053_abnormal_anal_canal2.77211393
9MP0009250_abnormal_appendicular_skeleto2.45519668
10MP0005257_abnormal_intraocular_pressure2.42969980
11MP0003385_abnormal_body_wall2.39184409
12MP0009384_cardiac_valve_regurgitation2.35685690
13MP0001958_emphysema2.28324317
14MP0004272_abnormal_basement_membrane2.22127677
15MP0005508_abnormal_skeleton_morphology2.18404275
16MP0006054_spinal_hemorrhage2.17494665
17MP0003942_abnormal_urinary_system1.93834206
18MP0000049_abnormal_middle_ear1.89438804
19MP0010352_gastrointestinal_tract_polyps1.89211251
20MP0004858_abnormal_nervous_system1.84841571
21MP0005023_abnormal_wound_healing1.79186496
22MP0002932_abnormal_joint_morphology1.77563677
23MP0000733_abnormal_muscle_development1.77487480
24MP0003566_abnormal_cell_adhesion1.63593859
25MP0002282_abnormal_trachea_morphology1.63568983
26MP0003123_paternal_imprinting1.61901862
27MP0002249_abnormal_larynx_morphology1.61586867
28MP0000537_abnormal_urethra_morphology1.60863044
29MP0003937_abnormal_limbs/digits/tail_de1.58346941
30MP0003091_abnormal_cell_migration1.56444483
31MP0000751_myopathy1.54889808
32MP0003755_abnormal_palate_morphology1.54769803
33MP0001299_abnormal_eye_distance/1.53905174
34MP0000428_abnormal_craniofacial_morphol1.53442319
35MP0002060_abnormal_skin_morphology1.49800919
36MP0000534_abnormal_ureter_morphology1.41725069
37MP0001348_abnormal_lacrimal_gland1.41280523
38MP0002295_abnormal_pulmonary_circulatio1.37660910
39MP0002108_abnormal_muscle_morphology1.37360895
40MP0000163_abnormal_cartilage_morphology1.37116450
41MP0003122_maternal_imprinting1.36257243
42MP0003115_abnormal_respiratory_system1.36165102
43MP0001243_abnormal_dermal_layer1.36044231
44MP0002896_abnormal_bone_mineralization1.35696974
45MP0003950_abnormal_plasma_membrane1.34590947
46MP0002115_abnormal_skeleton_extremities1.34553183
47MP0001542_abnormal_bone_strength1.27535216
48MP0010368_abnormal_lymphatic_system1.26368028
49MP0000767_abnormal_smooth_muscle1.23135739
50MP0005367_renal/urinary_system_phenotyp1.22192289
51MP0000516_abnormal_urinary_system1.22192289
52MP0002233_abnormal_nose_morphology1.21922787
53MP0000750_abnormal_muscle_regeneration1.21640213
54MP0003935_abnormal_craniofacial_develop1.20299350
55MP0009780_abnormal_chondrocyte_physiolo1.19394598
56MP0002116_abnormal_craniofacial_bone1.17760844
57MP0003941_abnormal_skin_development1.17588962
58MP0004134_abnormal_chest_morphology1.17006379
59MP0005595_abnormal_vascular_smooth1.16421871
60MP0002109_abnormal_limb_morphology1.14625059
61MP0002113_abnormal_skeleton_development1.12067784
62MP0003283_abnormal_digestive_organ1.12042004
63MP0002111_abnormal_tail_morphology1.11564428
64MP0000432_abnormal_head_morphology1.09619010
65MP0000762_abnormal_tongue_morphology1.09088107
66MP0005076_abnormal_cell_differentiation1.08414843
67MP0002254_reproductive_system_inflammat1.06988529
68MP0005390_skeleton_phenotype1.05258567
69MP0002177_abnormal_outer_ear1.03434479
70MP0000003_abnormal_adipose_tissue0.99239360
71MP0002114_abnormal_axial_skeleton0.98663843
72MP0002877_abnormal_melanocyte_morpholog0.97364565
73MP0004233_abnormal_muscle_weight0.97153523
74MP0004197_abnormal_fetal_growth/weight/0.94103329
75MP0001849_ear_inflammation0.93155505
76MP0002933_joint_inflammation0.86783709
77MP0002925_abnormal_cardiovascular_devel0.85600974
78MP0002938_white_spotting0.83864635
79MP0002697_abnormal_eye_size0.83461508
80MP0002085_abnormal_embryonic_tissue0.82335701
81MP0001614_abnormal_blood_vessel0.82282200
82MP0010386_abnormal_urinary_bladder0.81429040
83MP0003448_altered_tumor_morphology0.81250847
84MP0005197_abnormal_uvea_morphology0.81067473
85MP0000759_abnormal_skeletal_muscle0.79022588
86MP0002128_abnormal_blood_circulation0.78446226
87MP0003567_abnormal_fetal_cardiomyocyte0.76800875
88MP0005248_abnormal_Harderian_gland0.76785714
89MP0003121_genomic_imprinting0.75911507
90MP0002089_abnormal_postnatal_growth/wei0.75872051
91MP0001340_abnormal_eyelid_morphology0.75224642
92MP0000013_abnormal_adipose_tissue0.74872324
93MP0002084_abnormal_developmental_patter0.74488118
94MP0008007_abnormal_cellular_replicative0.74319538
95MP0004808_abnormal_hematopoietic_stem0.74244592
96MP0005171_absent_coat_pigmentation0.74156512
97MP0001175_abnormal_lung_morphology0.73768634
98MP0001915_intracranial_hemorrhage0.73632573
99MP0003795_abnormal_bone_structure0.73422120
100MP0002092_abnormal_eye_morphology0.73247717
101MP0008932_abnormal_embryonic_tissue0.72997195
102MP0003119_abnormal_digestive_system0.71952645
103MP0005164_abnormal_response_to0.71519980
104MP0002168_other_aberrant_phenotype0.71228864
105MP0000566_synostosis0.68762279
106MP0005193_abnormal_anterior_eye0.68592393
107MP0000749_muscle_degeneration0.68531408
108MP0002998_abnormal_bone_remodeling0.66394163
109MP0000462_abnormal_digestive_system0.64960106
110MP0001697_abnormal_embryo_size0.63946848
111MP0001879_abnormal_lymphatic_vessel0.63906894
112MP0005380_embryogenesis_phenotype0.63363697
113MP0001672_abnormal_embryogenesis/_devel0.63363697
114MP0000350_abnormal_cell_proliferation0.63147777
115MP0005388_respiratory_system_phenotype0.62537704
116MP0002133_abnormal_respiratory_system0.62537704
117MP0000681_abnormal_thyroid_gland0.60376844
118MP0000467_abnormal_esophagus_morphology0.58948469
119MP0001270_distended_abdomen0.58421473
120MP0001533_abnormal_skeleton_physiology0.54545407
121MP0005058_abnormal_lysosome_morphology0.52631207
122MP0010771_integument_phenotype0.50710805
123MP0000538_abnormal_urinary_bladder0.49236768
124MP0003186_abnormal_redox_activity0.47137484
125MP0004883_abnormal_blood_vessel0.46447185
126MP0005165_increased_susceptibility_to0.42526798
127MP0005369_muscle_phenotype0.42508730
128MP0009840_abnormal_foam_cell0.41518027
129MP0005501_abnormal_skin_physiology0.40295788

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.34554091
2Premature rupture of membranes (HP:0001788)7.57565069
3Shallow orbits (HP:0000586)5.04985833
4Abnormality of dentin (HP:0010299)4.49652049
5Peritonitis (HP:0002586)4.48620864
6Ankle contracture (HP:0006466)4.34960151
7Soft skin (HP:0000977)4.23438524
8Aortic dissection (HP:0002647)4.19549640
9Atrophic scars (HP:0001075)3.88936821
10Bladder diverticulum (HP:0000015)3.82455395
11Biconcave vertebral bodies (HP:0004586)3.69856491
12Neonatal short-limb short stature (HP:0008921)3.59649445
13Genu recurvatum (HP:0002816)3.49395101
14Dilatation of the ascending aorta (HP:0005111)3.41558816
15Fragile skin (HP:0001030)3.38859651
16Broad metatarsal (HP:0001783)3.32766420
17Vertebral compression fractures (HP:0002953)3.32579929
18Cervical subluxation (HP:0003308)3.28406960
19Wormian bones (HP:0002645)3.26283645
20Blue sclerae (HP:0000592)3.20213879
21Type 1 muscle fiber predominance (HP:0003803)3.16301830
22Aortic aneurysm (HP:0004942)3.09447573
23Wrist flexion contracture (HP:0001239)3.02050628
24Cerebral aneurysm (HP:0004944)3.01664817
25Mitral valve prolapse (HP:0001634)3.01653189
26Spinal rigidity (HP:0003306)2.96915692
27Deviation of the hallux (HP:0010051)2.96366210
28Spondylolisthesis (HP:0003302)2.90651121
29Mesomelia (HP:0003027)2.88198772
30Bowel diverticulosis (HP:0005222)2.86404332
31Aortic regurgitation (HP:0001659)2.82934751
32Follicular hyperkeratosis (HP:0007502)2.82689650
33Hallux valgus (HP:0001822)2.80749447
34Hypoventilation (HP:0002791)2.71316185
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69097116
36Short 4th metacarpal (HP:0010044)2.69097116
37Abnormal delivery (HP:0001787)2.57030475
38Redundant skin (HP:0001582)2.55018818
39Elbow flexion contracture (HP:0002987)2.52348068
40Joint stiffness (HP:0001387)2.51799426
41Increased connective tissue (HP:0009025)2.50812281
42Renal duplication (HP:0000075)2.50273524
43Abnormality of the acetabulum (HP:0003170)2.49187696
44Hyperextensible skin (HP:0000974)2.48740943
45Aortic valve stenosis (HP:0001650)2.47709726
46Abnormality of the 4th metacarpal (HP:0010012)2.46332379
47Ulnar bowing (HP:0003031)2.44635318
48Wide anterior fontanel (HP:0000260)2.42988395
49Camptodactyly of toe (HP:0001836)2.39717231
50Infantile muscular hypotonia (HP:0008947)2.39268921
51Syringomyelia (HP:0003396)2.34927942
52Spinal cord lesions (HP:0100561)2.34927942
53Buphthalmos (HP:0000557)2.33352526
54Achilles tendon contracture (HP:0001771)2.32735511
55Breech presentation (HP:0001623)2.28913729
56Generalized amyotrophy (HP:0003700)2.27055042
57Overgrowth (HP:0001548)2.26882819
58Coronal craniosynostosis (HP:0004440)2.26882595
59Broad long bones (HP:0005622)2.26297490
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.25783375
61Osteolytic defects of the hand bones (HP:0009699)2.25783375
62Slender build (HP:0001533)2.23405734
63Vascular tortuosity (HP:0004948)2.20684893
64Abnormality of the 2nd finger (HP:0004100)2.16872079
65Aneurysm (HP:0002617)2.16764239
66Disproportionate tall stature (HP:0001519)2.16761532
67Abnormality of the peritoneum (HP:0002585)2.14841787
68Short middle phalanx of the 5th finger (HP:0004220)2.14773189
69Mildly elevated creatine phosphokinase (HP:0008180)2.14273385
70Joint laxity (HP:0001388)2.11974368
71Natal tooth (HP:0000695)2.11284197
72Abnormality of the calcaneus (HP:0008364)2.10697359
73Increased variability in muscle fiber diameter (HP:0003557)2.09214823
74Broad toe (HP:0001837)2.08623688
75Premature skin wrinkling (HP:0100678)2.08390385
76Round ear (HP:0100830)2.06026862
77Abnormality of the phalanges of the hallux (HP:0010057)2.05357662
78Increased density of long bones (HP:0006392)2.05047595
79Abnormality of the fetal cardiovascular system (HP:0010948)2.04700804
80Abnormal umbilical cord blood vessels (HP:0011403)2.04700804
81Single umbilical artery (HP:0001195)2.04700804
82Morphological abnormality of the middle ear (HP:0008609)2.03412211
83Short 5th finger (HP:0009237)2.03386568
84Congenital glaucoma (HP:0001087)2.01885383
85Mitral regurgitation (HP:0001653)2.01039508
86Abnormality of the Achilles tendon (HP:0005109)2.00830210
87Sparse lateral eyebrow (HP:0005338)1.99869588
88Long toe (HP:0010511)1.98798802
89Microglossia (HP:0000171)1.98401522
90Protruding ear (HP:0000411)1.97851124
91Thin bony cortex (HP:0002753)1.97261216
92Nonimmune hydrops fetalis (HP:0001790)1.97148766
93Distal upper limb amyotrophy (HP:0007149)1.96026004
94Upper limb amyotrophy (HP:0009129)1.96026004
95Turricephaly (HP:0000262)1.95905601
96Abnormality of skull ossification (HP:0002703)1.95746572
97Knee flexion contracture (HP:0006380)1.95718609
98Selective tooth agenesis (HP:0001592)1.94434749
99Slender long bone (HP:0003100)1.92799841
100Tibial bowing (HP:0002982)1.92565085
101Short nail (HP:0001799)1.92248342
102Osteoarthritis (HP:0002758)1.92203865
103Limb-girdle muscle weakness (HP:0003325)1.90905476
104Emphysema (HP:0002097)1.90546783
105Ovoid vertebral bodies (HP:0003300)1.89429905
106Calcaneovalgus deformity (HP:0001848)1.89419469
107Inguinal hernia (HP:0000023)1.89218107
108Bowed forearm bones (HP:0003956)1.89059248
109Bowing of the arm (HP:0006488)1.89059248
110Flat cornea (HP:0007720)1.89029479
111Asymmetry of the thorax (HP:0001555)1.88463553
112Deformed tarsal bones (HP:0008119)1.87388466
113Femoral bowing (HP:0002980)1.86870645
114Mild short stature (HP:0003502)1.86743119
115Ectopia lentis (HP:0001083)1.86624388
116Coxa vara (HP:0002812)1.86154382
117Broad thumb (HP:0011304)1.85518431
118Broad ribs (HP:0000885)1.85459258
119Thoracolumbar scoliosis (HP:0002944)1.85134346
120Delayed closure of the anterior fontanelle (HP:0001476)1.84612703
121Broad phalanx (HP:0006009)1.84273013
122Arterial tortuosity (HP:0005116)1.83428937
123Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.83110598
124Persistence of primary teeth (HP:0006335)1.82110474
125Abnormality of skeletal muscle fiber size (HP:0012084)1.81824614
126Short 1st metacarpal (HP:0010034)1.81757667
127Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81757667
128Radial bowing (HP:0002986)1.80507313
129Hyperacusis (HP:0010780)1.80021270
130Delayed cranial suture closure (HP:0000270)1.79273293
131Flexion contracture of toe (HP:0005830)1.79114211
132Joint contractures involving the joints of the feet (HP:0100492)1.79114211
133Broad hallux (HP:0010055)1.78599175
134Mitral stenosis (HP:0001718)1.76993700
135Absent frontal sinuses (HP:0002688)1.75621211
136Ulnar deviation of the wrist (HP:0003049)1.73826576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS25.34883134
2DDR24.24980759
3TRIB33.74897761
4TTN3.51392818
5PKN23.15882925
6PDGFRA2.97914594
7NME22.93645595
8LATS12.78418736
9EPHB22.51824060
10MAP3K102.26172366
11PAK22.23725950
12ERN12.07075645
13NTRK11.93932560
14LIMK11.75256159
15MOS1.74009539
16RPS6KA41.73911949
17TGFBR21.72864689
18TESK11.72710540
19SMG11.71181887
20STK381.67109005
21STK38L1.63222621
22BMX1.57919377
23ILK1.55933756
24TLK11.43708417
25LRRK21.40385149
26PTK21.40267504
27AKT31.38046060
28PTK61.36969660
29PAK41.36558702
30RIPK11.30798667
31PIM21.30422133
32STK31.27054374
33FGFR11.20381927
34EEF2K1.20366493
35KIT1.20342377
36TRPM71.17594073
37SIK11.17012710
38PAK11.08413972
39PAK31.07674738
40TESK21.03347147
41MAP3K61.00519710
42PTK2B0.99784498
43MKNK10.97599641
44PRKG20.97112427
45DMPK0.96470094
46MTOR0.94790646
47EPHA20.94540242
48PAK60.92931314
49BUB10.92872789
50GRK50.92730839
51ROCK10.92625843
52MAP3K80.91580606
53FER0.85364960
54NEK90.85198967
55DAPK30.83570915
56PRPF4B0.83358722
57RPS6KA20.82565482
58ROCK20.81634742
59BRSK20.81512428
60GRK70.81280933
61TAOK20.81117647
62ERBB40.78661817
63MET0.77550557
64MAPK70.77291205
65MELK0.76757984
66NEK20.74161612
67PDGFRB0.73481929
68IRAK30.72752071
69ABL20.70103230
70EPHB10.69970400
71MYLK0.69479898
72CDC42BPA0.68518126
73PRKD30.67715146
74ARAF0.62475147
75CDK120.61948325
76NEK10.61916435
77MAPKAPK30.61901553
78TTK0.61848604
79SCYL20.61826604
80RPS6KC10.61140444
81RPS6KL10.61140444
82CDK70.60676176
83PRKD10.59520239
84FLT30.58280447
85PIK3CA0.57552661
86RPS6KB20.55588075
87BRAF0.55165364
88AURKB0.54919127
89GSK3A0.54643405
90PRKD20.54414514
91ICK0.54219471
92CAMK2G0.53090022
93PIK3CG0.52923016
94CDK150.52641650
95FGFR40.52450522
96MAP2K10.51457014
97CDC70.50765847
98CLK10.50444420
99WNK10.50081840
100CDK140.49004469
101PLK10.48563616
102CDK80.48529280
103CDK11A0.48089037
104CDK180.47842450
105CDK60.47791399
106OBSCN0.47769705
107EPHA30.46510891
108MAP3K30.44860125
109JAK30.44716694
110RPS6KA60.44005906
111ERBB30.41041620
112PLK30.40921362
113DYRK1B0.39828888
114MARK20.39061399
115TBK10.38926234
116INSR0.38901914
117MKNK20.38888296
118MAP2K30.38856990
119ZAK0.38595386
120BRSK10.38441475
121GRK10.37291171
122AURKA0.36616746
123MST1R0.36313176
124TAOK10.34987516
125MAPK110.34987453
126PLK20.34098778
127PDPK10.32307683
128ADRBK10.31829478
129TGFBR10.31467367
130STK40.30464050
131CHEK20.30390441
132WEE10.29699336
133MAP3K120.28401527
134MAPKAPK20.27974745
135LMTK20.25903072
136CAMK10.24351696

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.61206963
2Ribosome_Homo sapiens_hsa030103.13289049
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.86588842
4Focal adhesion_Homo sapiens_hsa045102.79742638
5Basal cell carcinoma_Homo sapiens_hsa052172.74066586
6Proteoglycans in cancer_Homo sapiens_hsa052052.56796529
7Bladder cancer_Homo sapiens_hsa052192.53180232
8Hippo signaling pathway_Homo sapiens_hsa043902.51538736
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.48384008
10TGF-beta signaling pathway_Homo sapiens_hsa043502.45278021
11Hedgehog signaling pathway_Homo sapiens_hsa043402.27123147
12Adherens junction_Homo sapiens_hsa045202.15010477
13MicroRNAs in cancer_Homo sapiens_hsa052062.05123592
14p53 signaling pathway_Homo sapiens_hsa041152.03083122
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95087856
16Protein digestion and absorption_Homo sapiens_hsa049741.86526391
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85084744
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.84568922
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77115721
20Dilated cardiomyopathy_Homo sapiens_hsa054141.76113241
21Cell cycle_Homo sapiens_hsa041101.75702442
22Amoebiasis_Homo sapiens_hsa051461.68701350
23Small cell lung cancer_Homo sapiens_hsa052221.66040123
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.64884926
25Chronic myeloid leukemia_Homo sapiens_hsa052201.64772518
26Melanoma_Homo sapiens_hsa052181.64427084
27Other glycan degradation_Homo sapiens_hsa005111.62522100
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51486254
29Wnt signaling pathway_Homo sapiens_hsa043101.48573497
30Malaria_Homo sapiens_hsa051441.39500578
31HTLV-I infection_Homo sapiens_hsa051661.37410469
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36070861
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31228815
34RNA transport_Homo sapiens_hsa030131.28482305
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.27256364
36Spliceosome_Homo sapiens_hsa030401.26155194
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23276769
38Tight junction_Homo sapiens_hsa045301.19777991
39Pathways in cancer_Homo sapiens_hsa052001.19034599
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.18367422
41Prostate cancer_Homo sapiens_hsa052151.15565331
42Melanogenesis_Homo sapiens_hsa049161.10572981
43Vibrio cholerae infection_Homo sapiens_hsa051101.10525859
44One carbon pool by folate_Homo sapiens_hsa006701.09445350
45Galactose metabolism_Homo sapiens_hsa000521.09242656
46Glioma_Homo sapiens_hsa052141.06360190
47Shigellosis_Homo sapiens_hsa051311.06350515
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05220031
49Thyroid cancer_Homo sapiens_hsa052161.03669624
50Rap1 signaling pathway_Homo sapiens_hsa040151.01054289
51Viral carcinogenesis_Homo sapiens_hsa052030.99310216
52Colorectal cancer_Homo sapiens_hsa052100.99002322
53Axon guidance_Homo sapiens_hsa043600.98776835
54HIF-1 signaling pathway_Homo sapiens_hsa040660.98603984
55Lysosome_Homo sapiens_hsa041420.97728316
56Sulfur relay system_Homo sapiens_hsa041220.97665200
57Prion diseases_Homo sapiens_hsa050200.96713498
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.90580867
59Pancreatic cancer_Homo sapiens_hsa052120.87046388
60Endometrial cancer_Homo sapiens_hsa052130.85616731
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85178287
62Nucleotide excision repair_Homo sapiens_hsa034200.82728213
63Viral myocarditis_Homo sapiens_hsa054160.81851180
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80508170
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78548476
66DNA replication_Homo sapiens_hsa030300.77190319
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.76886868
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75937694
69Cocaine addiction_Homo sapiens_hsa050300.75653332
70Systemic lupus erythematosus_Homo sapiens_hsa053220.75249518
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74344657
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.71418300
73Renal cell carcinoma_Homo sapiens_hsa052110.70316702
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70092245
75Sulfur metabolism_Homo sapiens_hsa009200.69007780
76mTOR signaling pathway_Homo sapiens_hsa041500.67193114
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66367579
78mRNA surveillance pathway_Homo sapiens_hsa030150.65803194
79Platelet activation_Homo sapiens_hsa046110.65254417
80RNA polymerase_Homo sapiens_hsa030200.64997100
81Renin-angiotensin system_Homo sapiens_hsa046140.64226307
82Hepatitis B_Homo sapiens_hsa051610.63488008
83Gap junction_Homo sapiens_hsa045400.62982158
84N-Glycan biosynthesis_Homo sapiens_hsa005100.62235871
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61598141
86Notch signaling pathway_Homo sapiens_hsa043300.61120329
87Glutathione metabolism_Homo sapiens_hsa004800.59796471
88TNF signaling pathway_Homo sapiens_hsa046680.59468031
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59357519
90Non-small cell lung cancer_Homo sapiens_hsa052230.57881926
91Apoptosis_Homo sapiens_hsa042100.56734854
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.56549062
93Phagosome_Homo sapiens_hsa041450.55164634
94Sphingolipid metabolism_Homo sapiens_hsa006000.53346579
95Pentose phosphate pathway_Homo sapiens_hsa000300.52927094
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51466797
97Estrogen signaling pathway_Homo sapiens_hsa049150.51184235
98Oocyte meiosis_Homo sapiens_hsa041140.50291510
99VEGF signaling pathway_Homo sapiens_hsa043700.49534170
100FoxO signaling pathway_Homo sapiens_hsa040680.48525555
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48342106
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47108934
103Mismatch repair_Homo sapiens_hsa034300.46918721
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46601619
105Pertussis_Homo sapiens_hsa051330.46203671
106Ras signaling pathway_Homo sapiens_hsa040140.44138073
107Base excision repair_Homo sapiens_hsa034100.43826192
108Proteasome_Homo sapiens_hsa030500.43091451
109Complement and coagulation cascades_Homo sapiens_hsa046100.42875339
110Epstein-Barr virus infection_Homo sapiens_hsa051690.42050428
111GnRH signaling pathway_Homo sapiens_hsa049120.41937760
112Alcoholism_Homo sapiens_hsa050340.41622444
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39996593
114Thyroid hormone synthesis_Homo sapiens_hsa049180.39789577
115Toxoplasmosis_Homo sapiens_hsa051450.39563052
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39481278
117Vitamin B6 metabolism_Homo sapiens_hsa007500.38685862
118ErbB signaling pathway_Homo sapiens_hsa040120.38685851
119Hepatitis C_Homo sapiens_hsa051600.37899157
120AMPK signaling pathway_Homo sapiens_hsa041520.37510669
121Acute myeloid leukemia_Homo sapiens_hsa052210.37183319
122Salmonella infection_Homo sapiens_hsa051320.36112874
123Cardiac muscle contraction_Homo sapiens_hsa042600.35673874
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31998108
125MAPK signaling pathway_Homo sapiens_hsa040100.31911138
126Insulin signaling pathway_Homo sapiens_hsa049100.31491351
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31172792
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.30708849
129Endocytosis_Homo sapiens_hsa041440.30609544
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25646824

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