PRSS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sterol catabolic process (GO:0016127)7.27813842
2cholesterol catabolic process (GO:0006707)7.27813842
3intestinal absorption (GO:0050892)7.22146670
4neutrophil mediated immunity (GO:0002446)7.07738960
5polyketide metabolic process (GO:0030638)7.03693774
6doxorubicin metabolic process (GO:0044598)7.03693774
7daunorubicin metabolic process (GO:0044597)7.03693774
8transcytosis (GO:0045056)6.98254729
9Golgi transport vesicle coating (GO:0048200)6.66851545
10COPI coating of Golgi vesicle (GO:0048205)6.66851545
11arachidonic acid secretion (GO:0050482)6.54052282
12icosanoid secretion (GO:0032309)6.54052282
13phosphatidylinositol acyl-chain remodeling (GO:0036149)6.42427510
14phosphatidylserine acyl-chain remodeling (GO:0036150)6.31125375
15aminoglycoside antibiotic metabolic process (GO:0030647)6.30367926
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.23671892
17peptidyl-proline hydroxylation (GO:0019511)6.18780518
18regulation of acrosome reaction (GO:0060046)5.89586183
19regulation of keratinocyte differentiation (GO:0045616)5.77842750
20cysteine metabolic process (GO:0006534)5.77014711
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.50345061
22regulation of keratinocyte proliferation (GO:0010837)5.49338685
23icosanoid transport (GO:0071715)5.47272834
24fatty acid derivative transport (GO:1901571)5.47272834
25negative regulation of digestive system process (GO:0060457)5.36611479
26positive regulation of nuclease activity (GO:0032075)5.30929502
27proline biosynthetic process (GO:0006561)5.21234180
28endocrine pancreas development (GO:0031018)5.11352977
29innate immune response in mucosa (GO:0002227)5.06062194
30myeloid leukocyte mediated immunity (GO:0002444)5.05432859
31acute-phase response (GO:0006953)5.04472621
32protein hydroxylation (GO:0018126)4.92315752
33regulation of phospholipase A2 activity (GO:0032429)4.88970182
34membrane lipid catabolic process (GO:0046466)4.83970679
35regulation of nuclease activity (GO:0032069)4.81541450
36glycolipid catabolic process (GO:0019377)4.78635110
37digestive system process (GO:0022600)4.74968706
38endoplasmic reticulum unfolded protein response (GO:0030968)4.74473981
39intestinal epithelial cell development (GO:0060576)4.65722301
40protein maturation by protein folding (GO:0022417)4.59751190
41ceramide catabolic process (GO:0046514)4.58478176
42cellular response to unfolded protein (GO:0034620)4.56316598
43response to endoplasmic reticulum stress (GO:0034976)4.55826705
44cellular modified amino acid catabolic process (GO:0042219)4.47330273
45phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.45508811
46maintenance of gastrointestinal epithelium (GO:0030277)4.44321482
47calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.43193507
48branched-chain amino acid catabolic process (GO:0009083)4.42524283
49serine family amino acid biosynthetic process (GO:0009070)4.41959995
50ER-nucleus signaling pathway (GO:0006984)4.39251039
51valine metabolic process (GO:0006573)4.38790438
52mitochondrial calcium ion transport (GO:0006851)4.37809150
53phosphatidylserine metabolic process (GO:0006658)4.36877374
54cellular response to topologically incorrect protein (GO:0035967)4.36267119
55cellular protein catabolic process (GO:0044257)4.27548454
56homocysteine metabolic process (GO:0050667)4.15035719
57aspartate family amino acid catabolic process (GO:0009068)4.12977179
58mucosal immune response (GO:0002385)4.11224841
59leukotriene metabolic process (GO:0006691)4.09412394
604-hydroxyproline metabolic process (GO:0019471)4.07674468
61polarized epithelial cell differentiation (GO:0030859)4.00808020
62branched-chain amino acid metabolic process (GO:0009081)3.97854319
63antibacterial humoral response (GO:0019731)3.93495014
64zinc ion transport (GO:0006829)3.91369159
65maintenance of protein localization in organelle (GO:0072595)3.88289092
66regulation of metalloenzyme activity (GO:0048552)3.85398537
67glycine transport (GO:0015816)3.84244011
68phosphatidylcholine acyl-chain remodeling (GO:0036151)3.83860298
69* water-soluble vitamin metabolic process (GO:0006767)3.76523793
70L-phenylalanine catabolic process (GO:0006559)3.74524654
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.74524654
72organ or tissue specific immune response (GO:0002251)3.72637555
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.71939003
74L-serine metabolic process (GO:0006563)3.67948728
75regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.67422436
76steroid catabolic process (GO:0006706)3.66245199
77L-alpha-amino acid transmembrane transport (GO:1902475)3.64412950
78phosphatidic acid metabolic process (GO:0046473)3.63726441
79phosphatidic acid biosynthetic process (GO:0006654)3.63726441
80glutamine metabolic process (GO:0006541)3.63365692
81regulation of calcium ion import (GO:0090279)3.61891716
82antimicrobial humoral response (GO:0019730)3.61581106
83COPII vesicle coating (GO:0048208)3.61308278
84alditol phosphate metabolic process (GO:0052646)3.59053890
85acute inflammatory response (GO:0002526)3.57757301
86glutathione derivative biosynthetic process (GO:1901687)3.55283564
87glutathione derivative metabolic process (GO:1901685)3.55283564
88sphingolipid catabolic process (GO:0030149)3.54653462
89response to unfolded protein (GO:0006986)3.53863678
90progesterone metabolic process (GO:0042448)3.52287989
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.49218564
92L-phenylalanine metabolic process (GO:0006558)3.49218564
93defense response to Gram-positive bacterium (GO:0050830)3.48951035
94creatine metabolic process (GO:0006600)3.45948448
95proline metabolic process (GO:0006560)3.43495797
96response to topologically incorrect protein (GO:0035966)3.43112397
97cellular response to cadmium ion (GO:0071276)3.42836571
98phospholipid catabolic process (GO:0009395)3.42243614
99regulation of epidermal cell differentiation (GO:0045604)3.42026592
100glycoside metabolic process (GO:0016137)3.41016474
101primary alcohol catabolic process (GO:0034310)3.40683032
102negative regulation of epidermal cell differentiation (GO:0045605)3.39571234
103positive regulation of heat generation (GO:0031652)3.38997205
104positive regulation of wound healing (GO:0090303)3.38786620
105activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.35205825
106ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.35096583
107signal peptide processing (GO:0006465)3.31821846
108negative regulation of hormone metabolic process (GO:0032351)3.29747201
109retinoid metabolic process (GO:0001523)3.29743116
110nucleotide-sugar biosynthetic process (GO:0009226)3.29715145
111pancreas development (GO:0031016)3.27893739
112cellular response to zinc ion (GO:0071294)3.27826604
113ER overload response (GO:0006983)3.27474131
114negative regulation of epithelial cell differentiation (GO:0030857)3.27310963
115insulin-like growth factor receptor signaling pathway (GO:0048009)3.26416852
116serine family amino acid metabolic process (GO:0009069)3.26167734
117mitochondrion distribution (GO:0048311)3.24442645
118regulation of fever generation (GO:0031620)3.23383590
119protein N-linked glycosylation via asparagine (GO:0018279)3.23203306
120peptidyl-asparagine modification (GO:0018196)3.23022653
121glandular epithelial cell differentiation (GO:0002067)3.19880532
122coenzyme catabolic process (GO:0009109)3.15342473
123leukotriene biosynthetic process (GO:0019370)3.14964677
124* tetrapyrrole metabolic process (GO:0033013)3.13942689
125establishment of apical/basal cell polarity (GO:0035089)3.11212395
126diterpenoid metabolic process (GO:0016101)3.10886850
127epithelial structure maintenance (GO:0010669)3.10153856
128regulation of triglyceride catabolic process (GO:0010896)3.09689193
129fatty acid derivative biosynthetic process (GO:1901570)3.09359202
130icosanoid biosynthetic process (GO:0046456)3.09359202
131cholesterol transport (GO:0030301)3.05072690
132sterol transport (GO:0015918)3.05072690
133peptide catabolic process (GO:0043171)3.03382395
134regulation of hormone metabolic process (GO:0032350)2.99984118
135multicellular organismal catabolic process (GO:0044243)2.98309535
136* vitamin metabolic process (GO:0006766)2.95157177
137protein N-linked glycosylation (GO:0006487)2.94219076
138phototransduction, visible light (GO:0007603)2.91971905
139retinal metabolic process (GO:0042574)2.89511501
140glycine metabolic process (GO:0006544)2.87789346
141cell redox homeostasis (GO:0045454)2.85496955
142multicellular organismal metabolic process (GO:0044236)2.84894224
143regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.84495783
144retinoic acid receptor signaling pathway (GO:0048384)2.83411684
145negative regulation of mRNA metabolic process (GO:1903312)2.82906025
146negative regulation of epidermis development (GO:0045683)2.80734502
147phosphatidylglycerol metabolic process (GO:0046471)2.80688926
148peroxisome fission (GO:0016559)2.79087843
149one-carbon metabolic process (GO:0006730)2.78793112
150endothelial cell migration (GO:0043542)2.78091225
151glucuronate metabolic process (GO:0019585)2.76159657
152uronic acid metabolic process (GO:0006063)2.76159657
153regulation of oxidative stress-induced cell death (GO:1903201)2.76148041
154regulation of response to osmotic stress (GO:0047484)2.76055960
155negative regulation of cell fate commitment (GO:0010454)2.74066403
156terpenoid metabolic process (GO:0006721)2.73449561
157sulfur amino acid catabolic process (GO:0000098)2.71812039
158vesicle coating (GO:0006901)2.71611512
159positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.70515308
160alpha-amino acid biosynthetic process (GO:1901607)2.68545776
161lysine catabolic process (GO:0006554)2.67798820
162lysine metabolic process (GO:0006553)2.67798820
163cellular glucuronidation (GO:0052695)2.66145858
164establishment or maintenance of monopolar cell polarity (GO:0061339)2.66104110
165establishment of monopolar cell polarity (GO:0061162)2.66104110
166columnar/cuboidal epithelial cell development (GO:0002066)2.65872583
167renal absorption (GO:0070293)2.60939813
168* extracellular matrix disassembly (GO:0022617)2.57380541
169regulation of cholesterol homeostasis (GO:2000188)2.55586406
170macroautophagy (GO:0016236)2.53179541
171exocrine pancreas development (GO:0031017)16.6013372
172intestinal cholesterol absorption (GO:0030299)16.2433500
173* digestion (GO:0007586)13.4351621
174protein retention in ER lumen (GO:0006621)11.5325010
175maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.9849174
176* cobalamin metabolic process (GO:0009235)10.0090752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.86260749
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.60115946
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.20811290
4ERG_21242973_ChIP-ChIP_JURKAT_Human3.99078600
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.19495341
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61641869
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.60987821
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.34800919
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.31275577
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.28913288
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.19310921
12GATA4_25053715_ChIP-Seq_YYC3_Human2.15927532
13HTT_18923047_ChIP-ChIP_STHdh_Human2.11832175
14PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.09355478
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07958451
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07286216
17LXR_22292898_ChIP-Seq_THP-1_Human2.07074533
18TCF4_18268006_ChIP-ChIP_LS174T_Human2.02063551
19GATA6_25053715_ChIP-Seq_YYC3_Human1.99635311
20CREB1_26743006_Chip-Seq_LNCaP_Human1.97545095
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97450794
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96740640
23* SOX2_20726797_ChIP-Seq_SW620_Human1.87190407
24CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.83388808
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.79454976
26CHD1_26751641_Chip-Seq_LNCaP_Human1.76046555
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.75309990
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.74137035
29CLOCK_20551151_ChIP-Seq_293T_Human1.73174307
30SA1_27219007_Chip-Seq_ERYTHROID_Human1.70245948
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67417065
32FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.65632976
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59817098
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59680108
35RACK7_27058665_Chip-Seq_MCF-7_Human1.59227771
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57317364
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54196697
38PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.52363540
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51157540
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50895147
41P68_20966046_ChIP-Seq_HELA_Human1.50813437
42CTCF_27219007_Chip-Seq_Bcells_Human1.49394914
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49012913
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.48810777
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48770627
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46505898
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.44304004
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43075439
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40865097
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40275731
51SA1_27219007_Chip-Seq_Bcells_Human1.40032274
52FOXA1_25552417_ChIP-Seq_VCAP_Human1.39651950
53MYC_22102868_ChIP-Seq_BL_Human1.38847749
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38519457
55ZNF274_21170338_ChIP-Seq_K562_Hela1.37951076
56PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.37335595
57KDM2B_26808549_Chip-Seq_K562_Human1.36995103
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35543939
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34267408
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34146273
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.32196764
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32107868
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.31532612
64CJUN_26792858_Chip-Seq_BT549_Human1.30801518
65ETV1_20927104_ChIP-Seq_GIST48_Human1.30661947
66PHF8_20622853_ChIP-Seq_HELA_Human1.30163550
67* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30043192
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29617217
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29181420
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.28884022
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27943531
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25687856
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25504171
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25474232
75SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24943919
76GATA6_21074721_ChIP-Seq_CACO-2_Human1.24883567
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.24593808
78NFYA_21822215_ChIP-Seq_K562_Human1.23910629
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21601245
80EGR1_19032775_ChIP-ChIP_M12_Human1.21528261
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.21291139
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20914828
83RBPJ_21746931_ChIP-Seq_IB4_Human1.20562465
84TP63_22573176_ChIP-Seq_HFKS_Human1.20238208
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19459090
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18139415
87KDM2B_26808549_Chip-Seq_DND41_Human1.18019287
88GATA1_22025678_ChIP-Seq_K562_Human1.17599064
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17494579
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17418648
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17351586
92CBX2_22325352_ChIP-Seq_293T-Rex_Human1.15124118
93ATF3_27146783_Chip-Seq_COLON_Human1.13551686
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12346692
95FOXA2_19822575_ChIP-Seq_HepG2_Human1.12018084
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10694525
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08121183
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.07916623
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07793330
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06265370
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06194373
102GATA3_24758297_ChIP-Seq_MCF-7_Human1.05242306
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05083195
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04548682
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04371127
106BCOR_27268052_Chip-Seq_Bcells_Human1.02345290
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01973220
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01540717
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00828696
110FOXH1_21741376_ChIP-Seq_ESCs_Human1.00463087
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00057747
112NFYB_21822215_ChIP-Seq_K562_Human1.00007437
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99747020
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98232420
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98232420
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98232420
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97960925
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97664163
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96900819
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.96792669
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96620062
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95991437
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95945479
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.95535276
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.95535276
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92251990
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92113008
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92074854
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.91748991
130OCT4_20526341_ChIP-Seq_ESCs_Human0.91707473
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91511602
132SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91490240
133SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91490240
134CBP_21632823_ChIP-Seq_H3396_Human0.91435321
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90964610
136CEBPB_22108803_ChIP-Seq_LS180_Human0.90932577
137* ERA_21632823_ChIP-Seq_H3396_Human0.90797769
138GATA1_19941826_ChIP-Seq_K562_Human0.90783511
139CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90486892
140TP53_18474530_ChIP-ChIP_U2OS_Human0.90420860
141KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90323094
142EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90074642
143CTCF_20526341_ChIP-Seq_ESCs_Human0.89952746
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.89767740
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89514281
146ETS1_21867929_ChIP-Seq_TH2_Mouse0.88502265
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88308149
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87991618
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87579791
150CDX2_22108803_ChIP-Seq_LS180_Human0.85052880
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84949147
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81911387
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81911387
154P300_27268052_Chip-Seq_Bcells_Human0.81155553
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81029400
156P300_19829295_ChIP-Seq_ESCs_Human0.78864807
157FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78684048
158FOXA1_25329375_ChIP-Seq_VCAP_Human0.78684048
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76316500
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76210986
161* TAF2_19829295_ChIP-Seq_ESCs_Human0.74482921
162HNF4A_19822575_ChIP-Seq_HepG2_Human0.73822124
163SOX2_19829295_ChIP-Seq_ESCs_Human0.73696431
164NANOG_19829295_ChIP-Seq_ESCs_Human0.73696431
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.73424111
166TBL1_22424771_ChIP-Seq_293T_Human0.72935937
167IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71846439
168POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70009589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.89201900
2MP0001666_abnormal_nutrient_absorption8.38115861
3MP0005220_abnormal_exocrine_pancreas6.29201483
4MP0005365_abnormal_bile_salt5.96118953
5MP0003868_abnormal_feces_composition5.93148024
6MP0005084_abnormal_gallbladder_morpholo4.29732332
7MP0005085_abnormal_gallbladder_physiolo3.42406149
8MP0010386_abnormal_urinary_bladder3.32372172
9MP0002693_abnormal_pancreas_physiology3.00335962
10MP0002876_abnormal_thyroid_physiology2.63352753
11MP0003283_abnormal_digestive_organ2.63052273
12MP0003959_abnormal_lean_body2.49875730
13MP0003705_abnormal_hypodermis_morpholog2.47962093
14MP0003122_maternal_imprinting2.40240580
15MP0001944_abnormal_pancreas_morphology2.33287659
16MP0001664_abnormal_digestion2.26903193
17MP0004264_abnormal_extraembryonic_tissu2.05101982
18MP0003011_delayed_dark_adaptation1.95476145
19MP0003300_gastrointestinal_ulcer1.79898441
20MP0003123_paternal_imprinting1.78096492
21MP0002139_abnormal_hepatobiliary_system1.68803089
22MP0004233_abnormal_muscle_weight1.66243243
23MP0010234_abnormal_vibrissa_follicle1.64934738
24MP0005448_abnormal_energy_balance1.51464412
25MP0008438_abnormal_cutaneous_collagen1.44177345
26MP0003195_calcinosis1.41693555
27MP0002118_abnormal_lipid_homeostasis1.37146795
28MP0006054_spinal_hemorrhage1.36107069
29MP0003638_abnormal_response/metabolism_1.30254163
30MP0008789_abnormal_olfactory_epithelium1.18885015
31MP0002078_abnormal_glucose_homeostasis1.18057622
32MP0002132_abnormal_respiratory_system1.17746399
33MP0001756_abnormal_urination1.16344805
34MP0009840_abnormal_foam_cell1.08001884
35MP0000003_abnormal_adipose_tissue1.05257747
36MP0003252_abnormal_bile_duct1.03149721
37MP0005332_abnormal_amino_acid1.02189146
38MP0005499_abnormal_olfactory_system0.97949474
39MP0005394_taste/olfaction_phenotype0.97949474
40MP0000470_abnormal_stomach_morphology0.97059497
41MP0002909_abnormal_adrenal_gland0.93844623
42MP0010329_abnormal_lipoprotein_level0.93377695
43MP0008961_abnormal_basal_metabolism0.91971994
44MP0005408_hypopigmentation0.88575794
45MP0002277_abnormal_respiratory_mucosa0.88284750
46MP0005451_abnormal_body_composition0.88117387
47MP0000613_abnormal_salivary_gland0.86532616
48MP0004185_abnormal_adipocyte_glucose0.85810205
49MP0005165_increased_susceptibility_to0.83656506
50MP0003943_abnormal_hepatobiliary_system0.81630942
51MP0002928_abnormal_bile_duct0.81095769
52MP0003953_abnormal_hormone_level0.79824967
53MP0003656_abnormal_erythrocyte_physiolo0.79572228
54MP0001986_abnormal_taste_sensitivity0.77249548
55MP0004019_abnormal_vitamin_homeostasis0.77125034
56MP0002163_abnormal_gland_morphology0.76422429
57MP0000538_abnormal_urinary_bladder0.76218700
58MP0009703_decreased_birth_body0.76042081
59MP0010352_gastrointestinal_tract_polyps0.72285939
60MP0009643_abnormal_urine_homeostasis0.71954051
61MP0009384_cardiac_valve_regurgitation0.71939057
62MP0005360_urolithiasis0.69153726
63MP0009672_abnormal_birth_weight0.68632865
64MP0005535_abnormal_body_temperature0.68561681
65MP0005375_adipose_tissue_phenotype0.67281432
66MP0005452_abnormal_adipose_tissue0.64809477
67MP0002877_abnormal_melanocyte_morpholog0.62375063
68MP0008872_abnormal_physiological_respon0.61630826
69MP0000490_abnormal_crypts_of0.59886596
70MP0003119_abnormal_digestive_system0.59681566
71MP0005636_abnormal_mineral_homeostasis0.58767884
72MP0005187_abnormal_penis_morphology0.58508340
73MP0009780_abnormal_chondrocyte_physiolo0.57231975
74MP0000598_abnormal_liver_morphology0.56890849
75MP0001845_abnormal_inflammatory_respons0.55674439
76MP0005623_abnormal_meninges_morphology0.54332656
77MP0008875_abnormal_xenobiotic_pharmacok0.53688440
78MP0004272_abnormal_basement_membrane0.53347599
79MP0003186_abnormal_redox_activity0.51913453
80MP0002970_abnormal_white_adipose0.51190890
81MP0000609_abnormal_liver_physiology0.51174416
82MP0003866_abnormal_defecation0.50724502
83MP0002938_white_spotting0.50668771
84MP0003115_abnormal_respiratory_system0.50656426
85MP0005058_abnormal_lysosome_morphology0.49928679
86MP0000639_abnormal_adrenal_gland0.49677091
87MP0003121_genomic_imprinting0.48607108
88MP0001731_abnormal_postnatal_growth0.46948841
89MP0000367_abnormal_coat/_hair0.46875211
90MP0004858_abnormal_nervous_system0.45142233
91MP0002896_abnormal_bone_mineralization0.45087906
92MP0000955_abnormal_spinal_cord0.44562560
93MP0003436_decreased_susceptibility_to0.43905147
94MP0001501_abnormal_sleep_pattern0.43881634
95MP0001765_abnormal_ion_homeostasis0.43706188
96MP0008469_abnormal_protein_level0.43552029
97MP0002069_abnormal_eating/drinking_beha0.41578142
98MP0000462_abnormal_digestive_system0.40810413
99MP0008004_abnormal_stomach_pH0.40606742
100MP0003942_abnormal_urinary_system0.39884245
101MP0003879_abnormal_hair_cell0.39741461
102MP0005334_abnormal_fat_pad0.39248599
103MP0002796_impaired_skin_barrier0.39211258
104MP0005379_endocrine/exocrine_gland_phen0.39107524
105MP0009333_abnormal_splenocyte_physiolog0.38774778
106MP0002295_abnormal_pulmonary_circulatio0.38744237
107MP0003787_abnormal_imprinting0.38456502
108MP0003806_abnormal_nucleotide_metabolis0.37890083
109MP0003329_amyloid_beta_deposits0.37098365
110MP0002136_abnormal_kidney_physiology0.36522914
111MP0001542_abnormal_bone_strength0.35929992
112MP0002138_abnormal_hepatobiliary_system0.35677264
113MP0001873_stomach_inflammation0.35207532
114MP0005166_decreased_susceptibility_to0.34841708
115MP0002060_abnormal_skin_morphology0.34747189
116MP0009765_abnormal_xenobiotic_induced0.34389805
117MP0009642_abnormal_blood_homeostasis0.34370657
118MP0005666_abnormal_adipose_tissue0.33611135
119MP0003045_fibrosis0.32900481
120MP0002089_abnormal_postnatal_growth/wei0.32798395
121MP0002168_other_aberrant_phenotype0.32766208
122MP0000750_abnormal_muscle_regeneration0.32539097
123MP0004043_abnormal_pH_regulation0.32360567
124MP0006036_abnormal_mitochondrial_physio0.30988284
125MP0003950_abnormal_plasma_membrane0.30527528
126MP0004197_abnormal_fetal_growth/weight/0.30447361
127MP0005381_digestive/alimentary_phenotyp0.30398596
128MP0010678_abnormal_skin_adnexa0.30088993
129MP0008995_early_reproductive_senescence0.29877366
130MP0001340_abnormal_eyelid_morphology0.29342412
131MP0004811_abnormal_neuron_physiology0.28914782
132MP0005076_abnormal_cell_differentiation0.28571801
133MP0005410_abnormal_fertilization0.28553697
134MP0005319_abnormal_enzyme/_coenzyme0.27738607
135MP0001663_abnormal_digestive_system0.27436804
136MP0003172_abnormal_lysosome_physiology0.27296970
137MP0000858_altered_metastatic_potential0.27048864
138MP0003956_abnormal_body_size0.26846154
139MP0001485_abnormal_pinna_reflex0.26509666
140MP0005595_abnormal_vascular_smooth0.25817078
141MP0009763_increased_sensitivity_to0.22426655
142MP0000920_abnormal_myelination0.22236362
143MP0003075_altered_response_to0.21822267
144MP0003566_abnormal_cell_adhesion0.21649172
145MP0009764_decreased_sensitivity_to0.20808708
146MP0003453_abnormal_keratinocyte_physiol0.20707831
147MP0001502_abnormal_circadian_rhythm0.20424895
148MP0002166_altered_tumor_susceptibility0.19727161
149MP0001533_abnormal_skeleton_physiology0.19159114
150MP0000467_abnormal_esophagus_morphology0.19039635
151MP0001661_extended_life_span0.18492732

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of endocrine pancreas physiology (HP:0012093)5.67352416
2Abnormality of the pancreatic islet cells (HP:0006476)5.67352416
3Short chin (HP:0000331)5.38590214
4Decreased subcutaneous fat (HP:0001002)5.09132342
5Type I diabetes mellitus (HP:0100651)5.03772736
6Gout (HP:0001997)5.02956361
7Ketoacidosis (HP:0001993)4.94980924
8* Steatorrhea (HP:0002570)4.86822426
9Abnormal pancreas size (HP:0012094)4.79682262
10Abnormality of subcutaneous fat tissue (HP:0001001)4.67519090
11Maternal diabetes (HP:0009800)4.51587597
12* Fat malabsorption (HP:0002630)4.35483410
13* Exocrine pancreatic insufficiency (HP:0001738)4.30442888
14Ketosis (HP:0001946)4.27420555
15Abnormality of proline metabolism (HP:0010907)4.23099537
16Hydroxyprolinuria (HP:0003080)4.23099537
17Hyperinsulinemic hypoglycemia (HP:0000825)4.10304094
18Tetraparesis (HP:0002273)4.07824058
19Abnormality of the intrinsic pathway (HP:0010989)4.01511507
20Hypoglycemic coma (HP:0001325)3.91331346
21Goiter (HP:0000853)3.89279962
22Late onset (HP:0003584)3.87815150
23Hypoglycemic seizures (HP:0002173)3.76890297
24Pancreatic islet-cell hyperplasia (HP:0004510)3.72746599
25Vascular calcification (HP:0004934)3.58274777
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.54659572
27Joint stiffness (HP:0001387)3.47765369
28Hypoplasia of the pons (HP:0012110)3.44675075
29Large for gestational age (HP:0001520)3.43750996
30Abnormal sex determination (HP:0012244)3.37206607
31Sex reversal (HP:0012245)3.37206607
32Hyperglycemia (HP:0003074)3.28975678
33Abnormality of the pons (HP:0007361)3.16430533
34Cardiovascular calcification (HP:0011915)3.12770519
35Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00625571
36Hypercortisolism (HP:0001578)2.99283644
37Congenital glaucoma (HP:0001087)2.94685070
38Spastic diplegia (HP:0001264)2.82773899
39Abnormality of the common coagulation pathway (HP:0010990)2.81228581
40Enlarged penis (HP:0000040)2.80270152
41Hyperphosphatemia (HP:0002905)2.77439838
42Premature skin wrinkling (HP:0100678)2.73821718
43Cortical dysplasia (HP:0002539)2.70757988
44Congenital, generalized hypertrichosis (HP:0004540)2.65599104
45Carpal bone hypoplasia (HP:0001498)2.56883646
46Hypotension (HP:0002615)2.55851750
47Prenatal maternal abnormality (HP:0002686)2.55496763
48Optic nerve hypoplasia (HP:0000609)2.54872983
49Insulin-resistant diabetes mellitus (HP:0000831)2.53294740
50Ankyloglossia (HP:0010296)2.45534258
51Abnormality of the distal phalanges of the toes (HP:0010182)2.45494305
52Insulin resistance (HP:0000855)2.43667133
53Symptomatic seizures (HP:0011145)2.40109878
54Male infertility (HP:0003251)2.38792668
55Hypsarrhythmia (HP:0002521)2.37754749
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.35603000
57Reduced antithrombin III activity (HP:0001976)2.34044747
58Tubulointerstitial abnormality (HP:0001969)2.32770437
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.32454154
60Ileus (HP:0002595)2.30448124
61Fatigue (HP:0012378)2.28940690
62Asymmetry of the thorax (HP:0001555)2.28826775
63Type I transferrin isoform profile (HP:0003642)2.26448270
64Hepatoblastoma (HP:0002884)2.25285125
65EEG with generalized epileptiform discharges (HP:0011198)2.24514763
66Abnormality of the nasal septum (HP:0000419)2.23548164
67Abnormality of methionine metabolism (HP:0010901)2.22155661
68Pectus carinatum (HP:0000768)2.19999441
69Barrel-shaped chest (HP:0001552)2.19454610
70Lymphangioma (HP:0100764)2.18067600
71Unilateral renal agenesis (HP:0000122)2.15924688
72Abnormal tarsal ossification (HP:0008369)2.15306010
73Paraparesis (HP:0002385)2.14350499
74Epileptiform EEG discharges (HP:0011182)2.14029784
75* Pancreatitis (HP:0001733)2.13942439
76Growth hormone excess (HP:0000845)2.12908356
77Testicular neoplasm (HP:0010788)2.12298195
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10036639
79Increased CSF protein (HP:0002922)2.09640647
80Abnormality of purine metabolism (HP:0004352)2.08907391
81Neoplasm of the pancreas (HP:0002894)2.08863550
82Long foot (HP:0001833)2.07928679
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07304508
84Abnormal protein N-linked glycosylation (HP:0012347)2.07304508
85Abnormal protein glycosylation (HP:0012346)2.07304508
86Abnormal glycosylation (HP:0012345)2.07304508
87Absent eyelashes (HP:0000561)2.07198274
88Abnormality of small intestinal villus morphology (HP:0011472)2.06921946
89Villous atrophy (HP:0011473)2.06921946
90Macroorchidism (HP:0000053)2.06590002
91Small epiphyses (HP:0010585)2.06127539
92Rough bone trabeculation (HP:0100670)2.05787748
93Hyperparathyroidism (HP:0000843)2.03545149
94Abnormality of the renal cortex (HP:0011035)2.03268593
95Hyperglycinemia (HP:0002154)2.02119267
96Tubulointerstitial fibrosis (HP:0005576)2.01443619
97Hypoplasia of the odontoid process (HP:0003311)2.01332186
98Increased purine levels (HP:0004368)2.00768126
99Hyperuricemia (HP:0002149)2.00768126
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99925308
101Abnormal biliary tract morphology (HP:0012440)1.97478077
102Ventricular fibrillation (HP:0001663)1.96340416
103Dysostosis multiplex (HP:0000943)1.94351102
104Abnormality of glycine metabolism (HP:0010895)1.93517372
105Abnormality of serine family amino acid metabolism (HP:0010894)1.93517372
106Hyperglycinuria (HP:0003108)1.91178786
107Abnormality of urine glucose concentration (HP:0011016)1.90877611
108Glycosuria (HP:0003076)1.90877611
109Glomerulonephritis (HP:0000099)1.89185503
110Abnormality of dentin (HP:0010299)1.88969254
111Abnormal hemoglobin (HP:0011902)1.87237462
112Stenosis of the external auditory canal (HP:0000402)1.87136171
113Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87125352
114Malnutrition (HP:0004395)1.85611327
115Sparse eyelashes (HP:0000653)1.85069820
116Thoracolumbar scoliosis (HP:0002944)1.84850085
117Diaphragmatic weakness (HP:0009113)1.84598600
118Cortical visual impairment (HP:0100704)1.83719085
119Fragile skin (HP:0001030)1.83450575
120Abnormality of alanine metabolism (HP:0010916)1.82485372
121Hyperalaninemia (HP:0003348)1.82485372
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82485372
123Buphthalmos (HP:0000557)1.82373072
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82225564
125Rhabdomyolysis (HP:0003201)1.81044940
126Menstrual irregularities (HP:0000858)1.80090990
127Myocardial infarction (HP:0001658)1.80085637
128Tubulointerstitial nephritis (HP:0001970)1.79496305
129Progressive muscle weakness (HP:0003323)1.79315250
130* Abnormality of the pleura (HP:0002103)1.78807020
131Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.78753853
132Disproportionate short-trunk short stature (HP:0003521)1.78560544
133Popliteal pterygium (HP:0009756)1.78219226
134Abnormality of oral frenula (HP:0000190)1.77342872
135Severe short stature (HP:0003510)1.77079399
136Deep venous thrombosis (HP:0002625)1.75769107
137Increased serum pyruvate (HP:0003542)1.75128136
138Type II lissencephaly (HP:0007260)1.74858562
139Generalized hyperpigmentation (HP:0007440)1.73999665
140Tubular atrophy (HP:0000092)1.73801614
141Urinary glycosaminoglycan excretion (HP:0003541)1.71075068
142Mucopolysacchariduria (HP:0008155)1.71075068
143Right ventricular cardiomyopathy (HP:0011663)1.70792086
144Esophageal varix (HP:0002040)1.70422931
145Lower limb hyperreflexia (HP:0002395)1.69970166
146Glucose intolerance (HP:0000833)1.68414698
147Arterial tortuosity (HP:0005116)1.68314886
148Infantile muscular hypotonia (HP:0008947)1.68146441
149Congenital malformation of the right heart (HP:0011723)1.67259052
150Double outlet right ventricle (HP:0001719)1.67259052
151Rectal prolapse (HP:0002035)1.66891161
152Blue sclerae (HP:0000592)1.66830957
153Hand muscle atrophy (HP:0009130)1.66563823
154Acute hepatic failure (HP:0006554)1.65808220
155Gowers sign (HP:0003391)1.65304215
156Epiphyseal dysplasia (HP:0002656)1.64660971
157Atrophic scars (HP:0001075)1.63626400
158Cerebral aneurysm (HP:0004944)1.63104680
159Glossoptosis (HP:0000162)1.62588526
160Large hands (HP:0001176)1.62568729
161Methylmalonic acidemia (HP:0002912)1.62495487
162Abnormality of glycolysis (HP:0004366)1.61187856
163Abnormal trabecular bone morphology (HP:0100671)1.60411910
164Abnormality of fatty-acid metabolism (HP:0004359)1.58504550
165Limb-girdle muscle atrophy (HP:0003797)1.58445159
166Aplasia/hypoplasia of the uterus (HP:0008684)1.57684584
167Renal tubular acidosis (HP:0001947)1.56154013
168Distal lower limb muscle weakness (HP:0009053)1.53273421
169Abnormality of vitamin metabolism (HP:0100508)1.50868873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.67815293
2LMTK26.63417594
3PDK25.59012500
4TRIB35.41503338
5ERN15.03604645
6PKN24.64933798
7MAP2K24.45862333
8EPHA23.87629409
9MAP3K123.48679651
10STK243.46550332
11EIF2AK33.43587129
12INSRR3.30775802
13MAP3K32.58938281
14MST1R2.22254151
15GRK12.18809498
16PASK2.15268049
17OXSR12.09873494
18EIF2AK11.87622946
19STK161.80688582
20PAK21.79806033
21PTK61.76474419
22MAP2K11.73234753
23EEF2K1.69444062
24WNK41.67630033
25SCYL21.66694531
26MST41.57744587
27RIPK11.47956023
28TBK11.45235145
29BMPR1B1.43859143
30RPS6KB21.42607425
31STK38L1.41469969
32HIPK21.38829719
33NEK61.37297290
34TAOK31.35001248
35PRKG21.32989479
36DYRK1A1.30727759
37NLK1.28033467
38MYLK1.27701857
39ZAP701.27114356
40MAPK151.25237597
41LATS11.21345764
42FLT31.19919064
43IRAK11.19572437
44CAMKK11.19131598
45ERBB41.14671725
46MAP3K61.14486275
47PDGFRA1.10604143
48RET1.05919070
49MAP3K101.04714904
50LRRK21.04614060
51TGFBR21.04381057
52VRK21.04303357
53FRK1.02800644
54PDGFRB0.98285567
55DAPK10.97267043
56ILK0.95523067
57MAPKAPK30.95484789
58MAP3K20.93955595
59PRKD30.91184573
60SRPK10.91134818
61SIK10.90679421
62NME20.88620700
63MTOR0.88305050
64CDK80.88266151
65STK30.82294804
66DAPK20.80696247
67FGFR40.80678665
68TRPM70.80102434
69NTRK30.77232297
70MAPK70.72216785
71MAP3K140.71579972
72PTK20.70228381
73ERBB30.70190176
74NME10.69254391
75PRKCE0.68163054
76FER0.67641085
77DYRK1B0.64470384
78NTRK10.64239555
79UHMK10.64083498
80PIM20.61888088
81KSR20.60638531
82IRAK30.60011904
83IRAK20.59165718
84PRKCH0.57403195
85PRKCZ0.56934934
86DDR20.52753740
87CDK40.52047598
88TESK10.51478443
89MAP3K10.49207584
90ROCK10.48056797
91MET0.47207896
92CDK60.45995293
93TYRO30.45850017
94STK390.43873315
95MAP3K70.43543226
96PIK3CA0.43066941
97PRKCI0.42145684
98DAPK30.41354768
99SGK30.41138492
100EPHB10.39605986
101PDPK10.39232078
102NEK10.38861540
103PRKCQ0.38564024
104CLK10.38307052
105PIK3CG0.37000273
106PRKCD0.36705989
107PRKACB0.36463475
108WNK10.36378640
109JAK10.35808992
110MAPK30.35453714
111MAP4K20.35230949
112MELK0.34164895
113STK380.34048523
114PAK60.33810594
115ERBB20.33643715
116CSNK1E0.32720795
117ICK0.32642424
118TAOK10.31091059
119MAPK110.30978342
120PAK30.30552802
121ALK0.30269724
122PDK10.30120539
123PAK40.29593487
124MAP3K90.29457608
125PRKD10.29208529
126ADRBK20.28867440
127EPHA30.28541713
128IKBKE0.27618151
129MAP3K50.27601201
130MAPK10.27136561
131JAK20.26470693
132AKT10.26279790
133RPS6KB10.26187146
134MAP3K40.26030874
135CDC70.25553066
136FGFR30.23783414
137RPS6KA10.23702174
138NEK90.21473257
139RPS6KA30.20935358
140CDK50.20485315
141IKBKB0.19908407
142PRKDC0.19492728
143VRK10.19195792
144PRKCA0.18749320
145MAP3K80.18561983
146CASK0.18527336
147BMPR20.18455152
148MAPK120.17146014
149PRKAA10.16859416
150GSK3A0.16418487
151CDK190.16146302
152CAMKK20.15526345
153AKT20.14621630
154MAPK140.13560109
155MAPK90.12396209
156IGF1R0.12309638
157ABL10.09481532
158CDC42BPA0.09303704
159CDK11A0.09156036

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.46756683
2Fat digestion and absorption_Homo sapiens_hsa049756.05016857
3* Protein digestion and absorption_Homo sapiens_hsa049745.84937834
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.84547852
5Protein export_Homo sapiens_hsa030603.00762742
6Glycerolipid metabolism_Homo sapiens_hsa005612.89132469
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.30710053
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.27745236
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23907414
10Folate biosynthesis_Homo sapiens_hsa007901.96932160
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83467754
12Steroid biosynthesis_Homo sapiens_hsa001001.69153816
13Propanoate metabolism_Homo sapiens_hsa006401.29193127
14Insulin secretion_Homo sapiens_hsa049111.24789888
15Ether lipid metabolism_Homo sapiens_hsa005651.21037758
16Arachidonic acid metabolism_Homo sapiens_hsa005901.20254805
17Vitamin digestion and absorption_Homo sapiens_hsa049771.12918084
18N-Glycan biosynthesis_Homo sapiens_hsa005101.11990172
19Notch signaling pathway_Homo sapiens_hsa043301.11501874
20Selenocompound metabolism_Homo sapiens_hsa004501.07263991
21Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99204520
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96771237
23Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94616991
24Arginine and proline metabolism_Homo sapiens_hsa003300.93878577
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92619722
26Biosynthesis of amino acids_Homo sapiens_hsa012300.88538090
27Vitamin B6 metabolism_Homo sapiens_hsa007500.88531614
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88313168
29Renin-angiotensin system_Homo sapiens_hsa046140.88089599
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86033254
31Nitrogen metabolism_Homo sapiens_hsa009100.85787910
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82560040
33Starch and sucrose metabolism_Homo sapiens_hsa005000.80406045
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78975255
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78773297
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75762136
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74203416
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72390204
39Vibrio cholerae infection_Homo sapiens_hsa051100.70011345
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69209492
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67833082
42Sulfur metabolism_Homo sapiens_hsa009200.67260786
43Chemical carcinogenesis_Homo sapiens_hsa052040.65757487
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.64908655
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62686115
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.62320676
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.60218625
48Fatty acid degradation_Homo sapiens_hsa000710.59021455
49One carbon pool by folate_Homo sapiens_hsa006700.56792408
50Tryptophan metabolism_Homo sapiens_hsa003800.54372316
51* Influenza A_Homo sapiens_hsa051640.54242164
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52827928
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50823762
54Arginine biosynthesis_Homo sapiens_hsa002200.48561782
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47344222
56Linoleic acid metabolism_Homo sapiens_hsa005910.47054080
57Retinol metabolism_Homo sapiens_hsa008300.46319578
58Endometrial cancer_Homo sapiens_hsa052130.45502074
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44692981
60Pyruvate metabolism_Homo sapiens_hsa006200.44288759
61Complement and coagulation cascades_Homo sapiens_hsa046100.44156017
62beta-Alanine metabolism_Homo sapiens_hsa004100.44077620
63Circadian rhythm_Homo sapiens_hsa047100.44068561
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43624762
65Mineral absorption_Homo sapiens_hsa049780.41320635
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40098711
67VEGF signaling pathway_Homo sapiens_hsa043700.38675021
68Type II diabetes mellitus_Homo sapiens_hsa049300.38579987
69Non-small cell lung cancer_Homo sapiens_hsa052230.38121074
70Proteasome_Homo sapiens_hsa030500.35944207
71Hepatitis C_Homo sapiens_hsa051600.35844492
72Other glycan degradation_Homo sapiens_hsa005110.33683748
73Lysine degradation_Homo sapiens_hsa003100.31621772
74Butanoate metabolism_Homo sapiens_hsa006500.31079507
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29749723
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29176407
77Cocaine addiction_Homo sapiens_hsa050300.28633820
78Sphingolipid metabolism_Homo sapiens_hsa006000.28575514
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.28105313
80Carbon metabolism_Homo sapiens_hsa012000.25485967
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23692067
82Prostate cancer_Homo sapiens_hsa052150.23488685
83Type I diabetes mellitus_Homo sapiens_hsa049400.22728950
84Pentose phosphate pathway_Homo sapiens_hsa000300.22422006
85Legionellosis_Homo sapiens_hsa051340.22178092
86mTOR signaling pathway_Homo sapiens_hsa041500.22064100
87Lysosome_Homo sapiens_hsa041420.21775338
88Peroxisome_Homo sapiens_hsa041460.21545646
89Insulin resistance_Homo sapiens_hsa049310.21481609
90Pancreatic cancer_Homo sapiens_hsa052120.21352574
91Thyroid hormone synthesis_Homo sapiens_hsa049180.21053567
92Bladder cancer_Homo sapiens_hsa052190.20696268
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19850520
94Estrogen signaling pathway_Homo sapiens_hsa049150.19675546
95GABAergic synapse_Homo sapiens_hsa047270.18663272
96* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18325710
97Fatty acid metabolism_Homo sapiens_hsa012120.17659791
98Bile secretion_Homo sapiens_hsa049760.16790030
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15931040
100Viral myocarditis_Homo sapiens_hsa054160.15351943
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13753086
102Calcium signaling pathway_Homo sapiens_hsa040200.13752341
103Fatty acid elongation_Homo sapiens_hsa000620.13488150
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12324026
105Histidine metabolism_Homo sapiens_hsa003400.12076121
106Ovarian steroidogenesis_Homo sapiens_hsa049130.11728465
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11248895
108Regulation of autophagy_Homo sapiens_hsa041400.10717195
109Sulfur relay system_Homo sapiens_hsa041220.09988603
110Insulin signaling pathway_Homo sapiens_hsa049100.09396550
111Glutathione metabolism_Homo sapiens_hsa004800.09313083
112Galactose metabolism_Homo sapiens_hsa000520.09097168
113Tight junction_Homo sapiens_hsa045300.08905961
114Metabolic pathways_Homo sapiens_hsa011000.08645270
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.08406941
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08335972
117Cholinergic synapse_Homo sapiens_hsa047250.07887175
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.07821855
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.07015080
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.06927462
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.06428534
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06367582
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05049239
124Amphetamine addiction_Homo sapiens_hsa050310.04804796
125Phototransduction_Homo sapiens_hsa047440.04632117
126Ribosome_Homo sapiens_hsa030100.04488013
127Alzheimers disease_Homo sapiens_hsa050100.04172393
128TGF-beta signaling pathway_Homo sapiens_hsa043500.04043094
129Gastric acid secretion_Homo sapiens_hsa049710.03845210
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.03484735
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.03414806
132Dopaminergic synapse_Homo sapiens_hsa047280.03026038
133Collecting duct acid secretion_Homo sapiens_hsa049660.02518164
134Fructose and mannose metabolism_Homo sapiens_hsa000510.02115802
135Glucagon signaling pathway_Homo sapiens_hsa049220.01595793
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.01552185
137Colorectal cancer_Homo sapiens_hsa052100.01397584
138Adherens junction_Homo sapiens_hsa045200.00780087
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.00776970
140Renin secretion_Homo sapiens_hsa049240.00436119
141HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0812888
142Rheumatoid arthritis_Homo sapiens_hsa05323-0.0678429
143ABC transporters_Homo sapiens_hsa02010-0.0565282
144Tyrosine metabolism_Homo sapiens_hsa00350-0.0520688
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0496072
146Oxidative phosphorylation_Homo sapiens_hsa00190-0.0003126

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