PRSS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.48708995
2cilium or flagellum-dependent cell motility (GO:0001539)6.83919003
3cilium movement (GO:0003341)5.35244980
4motile cilium assembly (GO:0044458)5.16760852
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.02890813
6protein heterotrimerization (GO:0070208)4.82477429
7establishment of apical/basal cell polarity (GO:0035089)4.61443335
8collagen fibril organization (GO:0030199)4.58880927
9mesenchymal-epithelial cell signaling (GO:0060638)4.56011601
10kidney mesenchyme development (GO:0072074)4.54855027
11synaptic vesicle maturation (GO:0016188)4.45280871
12metanephric mesenchyme development (GO:0072075)4.44074664
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34422613
14skin morphogenesis (GO:0043589)4.31766671
15lateral sprouting from an epithelium (GO:0060601)4.31163744
16regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.22976986
17cell migration involved in heart development (GO:0060973)4.22436334
18establishment of planar polarity (GO:0001736)4.16109674
19establishment of tissue polarity (GO:0007164)4.16109674
20epithelial cilium movement (GO:0003351)4.14942794
21left/right pattern formation (GO:0060972)4.03834706
22establishment or maintenance of monopolar cell polarity (GO:0061339)4.00534893
23establishment of monopolar cell polarity (GO:0061162)4.00534893
24glutamate secretion (GO:0014047)3.99780053
25bone trabecula formation (GO:0060346)3.91259862
26synaptic vesicle exocytosis (GO:0016079)3.90023304
27prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.84789999
28layer formation in cerebral cortex (GO:0021819)3.82046329
29neuronal action potential propagation (GO:0019227)3.81911978
30neuronal ion channel clustering (GO:0045161)3.81521512
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78484116
32chondrocyte proliferation (GO:0035988)3.69280284
33locomotory exploration behavior (GO:0035641)3.67818888
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.66737451
35craniofacial suture morphogenesis (GO:0097094)3.63492388
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.61900599
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.60674388
38paraxial mesoderm development (GO:0048339)3.57099890
39regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.55654145
40vocalization behavior (GO:0071625)3.54161931
41type B pancreatic cell proliferation (GO:0044342)3.53341634
42protein localization to synapse (GO:0035418)3.52005065
43exploration behavior (GO:0035640)3.49623808
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45571338
45activation of protein kinase A activity (GO:0034199)3.42026500
46hemidesmosome assembly (GO:0031581)3.41742268
47proline transport (GO:0015824)3.41082649
48endodermal cell differentiation (GO:0035987)3.33897385
49sequestering of extracellular ligand from receptor (GO:0035581)3.31953196
50positive regulation of smoothened signaling pathway (GO:0045880)3.28742833
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.26248021
52negative regulation of chondrocyte differentiation (GO:0032331)3.25847218
53regulation of axon extension involved in axon guidance (GO:0048841)3.25791310
54neuron recognition (GO:0008038)3.23651409
55axonal fasciculation (GO:0007413)3.22824966
56regulation of glutamate receptor signaling pathway (GO:1900449)3.21102955
57keratinocyte proliferation (GO:0043616)3.20662656
58regulation of synaptic vesicle exocytosis (GO:2000300)3.18940665
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.18650318
60central nervous system projection neuron axonogenesis (GO:0021952)3.17750979
61regulation of dendritic spine morphogenesis (GO:0061001)3.17244317
62axoneme assembly (GO:0035082)3.17179334
63neuron cell-cell adhesion (GO:0007158)3.16980425
64negative regulation of axon extension involved in axon guidance (GO:0048843)3.14171628
65endocardial cushion development (GO:0003197)3.13793671
66extracellular matrix assembly (GO:0085029)3.11843205
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.08418776
68neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.07709474
69regulation of establishment of planar polarity (GO:0090175)3.07367174
70negative regulation of catenin import into nucleus (GO:0035414)3.05804571
71planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05111643
72extracellular fibril organization (GO:0043206)3.03797881
73desmosome organization (GO:0002934)3.03255952
74dendrite morphogenesis (GO:0048813)3.02890689
75dendritic spine morphogenesis (GO:0060997)3.00961826
76midgut development (GO:0007494)3.00866962
77collagen metabolic process (GO:0032963)3.00493582
78regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.99893491
79hypotonic response (GO:0006971)2.99386620
80regulation of neuronal synaptic plasticity (GO:0048168)2.98993315
81negative regulation of embryonic development (GO:0045992)2.95026834
82tooth mineralization (GO:0034505)2.94317255
83innervation (GO:0060384)2.92414982
84collagen catabolic process (GO:0030574)2.92207792
85embryonic cranial skeleton morphogenesis (GO:0048701)2.91751880
86regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.91617053
87left/right axis specification (GO:0070986)2.91574989
88regulation of axon guidance (GO:1902667)2.88691970
89negative regulation of osteoblast proliferation (GO:0033689)2.88338293
90multicellular organismal macromolecule metabolic process (GO:0044259)2.87677189
91cellular potassium ion homeostasis (GO:0030007)2.86905279
92protein targeting to plasma membrane (GO:0072661)2.86080410
93regulation of non-canonical Wnt signaling pathway (GO:2000050)2.85733615
94behavioral fear response (GO:0001662)2.85596611
95behavioral defense response (GO:0002209)2.85596611
96clathrin coat assembly (GO:0048268)2.84328927
97regulation of synaptic vesicle transport (GO:1902803)2.82545249
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82352606
99establishment or maintenance of apical/basal cell polarity (GO:0035088)2.81888404
100establishment or maintenance of bipolar cell polarity (GO:0061245)2.81888404
101glomerular epithelial cell development (GO:0072310)2.81454529
102cell proliferation involved in metanephros development (GO:0072203)2.80628532
103polarized epithelial cell differentiation (GO:0030859)2.79797179
104dermatan sulfate metabolic process (GO:0030205)2.78282568
105embryonic forelimb morphogenesis (GO:0035115)2.77755618
106negative regulation of stem cell proliferation (GO:2000647)2.77632225
107cochlea morphogenesis (GO:0090103)2.77290602
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.77281023
109pericardium development (GO:0060039)2.76826039
110glutamate receptor signaling pathway (GO:0007215)2.75888970
111regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.73542208
112response to pheromone (GO:0019236)2.73385865
113positive regulation of fibroblast migration (GO:0010763)2.71538369
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.71516215
115multicellular organismal catabolic process (GO:0044243)2.70706150
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70527255
117smooth muscle tissue development (GO:0048745)2.70395138
118multicellular organismal metabolic process (GO:0044236)2.70160747
119branching involved in salivary gland morphogenesis (GO:0060445)2.70031088
120chondrocyte development (GO:0002063)2.69390813
121ventricular system development (GO:0021591)2.69335192
122synaptic vesicle endocytosis (GO:0048488)2.68304477
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.68034714
124axon extension involved in axon guidance (GO:0048846)2.68034714
125axon extension (GO:0048675)2.67959684
126regulation of dendritic spine development (GO:0060998)2.66504098
127glial cell migration (GO:0008347)2.66247903
128branching involved in prostate gland morphogenesis (GO:0060442)2.66094586
129extracellular regulation of signal transduction (GO:1900115)2.65420172
130extracellular negative regulation of signal transduction (GO:1900116)2.65420172
131cell proliferation involved in kidney development (GO:0072111)2.65314557
132semaphorin-plexin signaling pathway (GO:0071526)2.65192392
133cell migration involved in sprouting angiogenesis (GO:0002042)2.64761536
134negative regulation of JUN kinase activity (GO:0043508)2.64752919
135regulation of pigment cell differentiation (GO:0050932)2.60134120
136cell-substrate junction assembly (GO:0007044)2.59923972
137neurotransmitter secretion (GO:0007269)2.59507346
138hippo signaling (GO:0035329)2.59297849
139regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59227027
140negative regulation of axon guidance (GO:1902668)2.58948954
141regulation of cardioblast proliferation (GO:0003264)2.58940860
142regulation of secondary heart field cardioblast proliferation (GO:0003266)2.58940860
143diterpenoid biosynthetic process (GO:0016102)2.57822972
144negative regulation of keratinocyte proliferation (GO:0010839)2.57544728
145fear response (GO:0042596)2.57163342
146extracellular matrix disassembly (GO:0022617)2.55168951
147non-canonical Wnt signaling pathway (GO:0035567)2.54899542
148muscle cell migration (GO:0014812)2.54566475
149positive regulation of dendritic spine development (GO:0060999)2.54516805
150peripheral nervous system axon ensheathment (GO:0032292)2.53854931
151myelination in peripheral nervous system (GO:0022011)2.53854931
152regulation of synaptic plasticity (GO:0048167)2.53743600
153regulation of synapse structural plasticity (GO:0051823)2.53525191
154regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.53261782
155apoptotic cell clearance (GO:0043277)2.52645226
156dendritic spine organization (GO:0097061)2.52200700
157artery morphogenesis (GO:0048844)2.51849215
158central nervous system neuron axonogenesis (GO:0021955)2.51439682
159negative regulation of smooth muscle cell migration (GO:0014912)2.51408824
160cellular response to vitamin D (GO:0071305)2.51281427
161synaptic transmission, glutamatergic (GO:0035249)2.51268065
162fibril organization (GO:0097435)2.50998246
163lung vasculature development (GO:0060426)2.50704520
164convergent extension (GO:0060026)2.49450155
165negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.49080655
166microtubule bundle formation (GO:0001578)2.49003452
167notochord development (GO:0030903)2.48682327
168vesicle transport along microtubule (GO:0047496)2.48290280
169branching involved in labyrinthine layer morphogenesis (GO:0060670)2.48209629
170neural crest cell development (GO:0014032)2.47916668
171long-term synaptic potentiation (GO:0060291)2.47524966
172radial glial cell differentiation (GO:0060019)2.46706020
173protein targeting to Golgi (GO:0000042)2.45509391
174regulation of response to osmotic stress (GO:0047484)2.44948589
175postsynaptic membrane organization (GO:0001941)2.44774769
176cellular response to prostaglandin stimulus (GO:0071379)2.43894353
177cell migration in hindbrain (GO:0021535)2.43041918
178protein localization to cell surface (GO:0034394)2.42923751
179neuron-neuron synaptic transmission (GO:0007270)2.41477097
180positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41135406
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.39967104
182mesenchymal cell proliferation (GO:0010463)2.39894886
183neuron projection extension (GO:1990138)2.39686433
184digestive tract morphogenesis (GO:0048546)2.39483030
185trabecula formation (GO:0060343)2.38952963
186dermatan sulfate biosynthetic process (GO:0030208)2.38565155
187regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37755168
188renal system development (GO:0072001)2.37621713
189membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37234355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68888576
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.77848417
3GBX2_23144817_ChIP-Seq_PC3_Human3.15975876
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.11817127
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.01198170
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98828255
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94318350
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85731094
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83314586
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73473738
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73473738
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68646453
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66572502
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.61482624
15AR_21572438_ChIP-Seq_LNCaP_Human2.58158768
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48282456
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.46621347
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42205562
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37287611
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15990996
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13689552
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.09311831
23* BRD4_25478319_ChIP-Seq_HGPS_Human2.06921913
24DROSHA_22980978_ChIP-Seq_HELA_Human2.03951393
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97029737
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96619128
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90569541
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90519531
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87884330
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87881325
31* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85695237
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.84344848
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80056323
34CJUN_26792858_Chip-Seq_BT549_Human1.77037504
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73411406
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71314083
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71152262
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70922263
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69838387
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63368308
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63348339
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.62791010
43* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62783823
44AHR_22903824_ChIP-Seq_MCF-7_Human1.60366612
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58560899
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57847916
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.55529657
48CLOCK_20551151_ChIP-Seq_293T_Human1.54267920
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53795383
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.53626956
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49292487
52REST_21632747_ChIP-Seq_MESCs_Mouse1.48608878
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48269326
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.48082895
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.47015860
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44965797
57P300_19829295_ChIP-Seq_ESCs_Human1.44457972
58TP53_16413492_ChIP-PET_HCT116_Human1.44033183
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.42062269
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40719976
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.40270949
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39176027
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37581416
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37372605
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37372605
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36922094
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35652673
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35082198
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.34887646
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33823278
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30835603
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.29534501
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29104149
74* TP53_22127205_ChIP-Seq_IMR90_Human1.28672958
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28397929
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28087965
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27433557
78* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27055214
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.26524452
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.26367785
81TAF15_26573619_Chip-Seq_HEK293_Human1.25453633
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25303634
83* TP53_18474530_ChIP-ChIP_U2OS_Human1.24596795
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.24093412
85* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23910864
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20828720
87* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20361437
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18603972
89FUS_26573619_Chip-Seq_HEK293_Human1.18413534
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17907127
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17892144
92* TP63_23658742_ChIP-Seq_EP156T_Human1.17810943
93AR_19668381_ChIP-Seq_PC3_Human1.17613537
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16889425
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16889425
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16736837
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.16037952
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.15404898
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15336226
100RXR_22108803_ChIP-Seq_LS180_Human1.14730741
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14357806
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14219318
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13652960
104STAT3_23295773_ChIP-Seq_U87_Human1.13026390
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12957168
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12323835
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12049236
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.11815343
109SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11624137
110AR_25329375_ChIP-Seq_VCAP_Human1.11507682
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.09971456
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09748855
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09535997
114REST_18959480_ChIP-ChIP_MESCs_Mouse1.07889620
115BCAT_22108803_ChIP-Seq_LS180_Human1.07578883
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.06951195
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.05524505
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03127948
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02639442
120KDM2B_26808549_Chip-Seq_K562_Human1.02487263
121SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02439385
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02390225
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01993426
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01800289
125RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01501744
126CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00978086
127CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00972143
128FOXO3_23340844_ChIP-Seq_DLD1_Human1.00288874
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99313029
130KLF5_25053715_ChIP-Seq_YYC3_Human0.99149535
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98269961
132RACK7_27058665_Chip-Seq_MCF-7_Human0.98157081
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97766564
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97721741
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.97117350
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.96746237
137* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96087741
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95990988
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.93993691
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91969190
141ZNF274_21170338_ChIP-Seq_K562_Hela0.90892404
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.90071408
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.90039511
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.89755742
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.89622208
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89394741
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89394741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.72419507
2MP0004272_abnormal_basement_membrane3.33537890
3MP0005187_abnormal_penis_morphology3.27553239
4MP0003880_abnormal_central_pattern3.03786520
5MP0005503_abnormal_tendon_morphology2.97558682
6MP0003635_abnormal_synaptic_transmissio2.91862118
7MP0003279_aneurysm2.90540667
8MP0004270_analgesia2.78886329
9MP0009384_cardiac_valve_regurgitation2.49062157
10MP0001968_abnormal_touch/_nociception2.39173783
11MP0001299_abnormal_eye_distance/2.34386364
12MP0006054_spinal_hemorrhage2.25689538
13MP0002063_abnormal_learning/memory/cond2.24166738
14MP0003941_abnormal_skin_development2.10551274
15MP0001542_abnormal_bone_strength2.06970526
16MP0009745_abnormal_behavioral_response1.99854336
17MP0002064_seizures1.97900226
18MP0009780_abnormal_chondrocyte_physiolo1.95798210
19MP0005248_abnormal_Harderian_gland1.95596698
20MP0002734_abnormal_mechanical_nocicepti1.93551770
21MP0003566_abnormal_cell_adhesion1.92059664
22MP0000751_myopathy1.90926503
23MP0002938_white_spotting1.89807230
24MP0000778_abnormal_nervous_system1.88363193
25MP0004858_abnormal_nervous_system1.84251307
26* MP0002572_abnormal_emotion/affect_behav1.84178211
27MP0002060_abnormal_skin_morphology1.83418332
28MP0001984_abnormal_olfaction1.82170262
29MP0001486_abnormal_startle_reflex1.75050746
30MP0005623_abnormal_meninges_morphology1.74826753
31MP0002272_abnormal_nervous_system1.69734742
32MP0005275_abnormal_skin_tensile1.67062060
33MP0001440_abnormal_grooming_behavior1.64836027
34MP0008438_abnormal_cutaneous_collagen1.64836002
35MP0009250_abnormal_appendicular_skeleto1.62056594
36MP0009046_muscle_twitch1.61216180
37MP0002733_abnormal_thermal_nociception1.59726906
38MP0003091_abnormal_cell_migration1.58629446
39MP0006276_abnormal_autonomic_nervous1.58030157
40MP0005023_abnormal_wound_healing1.57865690
41MP0002735_abnormal_chemical_nociception1.55358855
42MP0000537_abnormal_urethra_morphology1.54799237
43MP0003385_abnormal_body_wall1.51431158
44MP0002108_abnormal_muscle_morphology1.49313037
45MP0000372_irregular_coat_pigmentation1.48776162
46MP0002102_abnormal_ear_morphology1.44640349
47MP0003329_amyloid_beta_deposits1.43452933
48MP0000579_abnormal_nail_morphology1.41735837
49MP0010352_gastrointestinal_tract_polyps1.41704095
50MP0010234_abnormal_vibrissa_follicle1.41324560
51MP0010368_abnormal_lymphatic_system1.40862965
52MP0000049_abnormal_middle_ear1.40194032
53MP0000955_abnormal_spinal_cord1.39527959
54MP0001243_abnormal_dermal_layer1.37079817
55MP0002184_abnormal_innervation1.36396231
56MP0002736_abnormal_nociception_after1.35974855
57MP0001970_abnormal_pain_threshold1.35219811
58MP0001849_ear_inflammation1.34589345
59MP0000767_abnormal_smooth_muscle1.34314358
60MP0002067_abnormal_sensory_capabilities1.33412587
61MP0000534_abnormal_ureter_morphology1.32841552
62MP0003937_abnormal_limbs/digits/tail_de1.30890577
63MP0000013_abnormal_adipose_tissue1.30130803
64MP0003942_abnormal_urinary_system1.29629479
65MP0008569_lethality_at_weaning1.26876857
66MP0001661_extended_life_span1.26835807
67MP0001501_abnormal_sleep_pattern1.26474308
68* MP0002557_abnormal_social/conspecific_i1.23826469
69MP0003122_maternal_imprinting1.22217855
70MP0000428_abnormal_craniofacial_morphol1.20938070
71MP0003115_abnormal_respiratory_system1.19986755
72MP0005257_abnormal_intraocular_pressure1.19965104
73* MP0004811_abnormal_neuron_physiology1.19893392
74MP0000432_abnormal_head_morphology1.19608021
75MP0010386_abnormal_urinary_bladder1.18623322
76MP0004134_abnormal_chest_morphology1.18075424
77MP0001879_abnormal_lymphatic_vessel1.16129097
78MP0000733_abnormal_muscle_development1.13181544
79MP0001177_atelectasis1.11993588
80MP0003632_abnormal_nervous_system1.11688967
81MP0000427_abnormal_hair_cycle1.08405549
82MP0005386_behavior/neurological_phenoty1.07831152
83MP0004924_abnormal_behavior1.07831152
84MP0000647_abnormal_sebaceous_gland1.07444450
85MP0000762_abnormal_tongue_morphology1.07148832
86* MP0002882_abnormal_neuron_morphology1.07089524
87MP0002249_abnormal_larynx_morphology1.06666522
88MP0008961_abnormal_basal_metabolism1.06611229
89MP0009053_abnormal_anal_canal1.05893163
90MP0005076_abnormal_cell_differentiation1.05545164
91MP0001958_emphysema1.04904004
92MP0004885_abnormal_endolymph1.03971239
93MP0002932_abnormal_joint_morphology1.02584782
94MP0005499_abnormal_olfactory_system1.02388531
95MP0005394_taste/olfaction_phenotype1.02388531
96MP0005367_renal/urinary_system_phenotyp1.01364070
97MP0000516_abnormal_urinary_system1.01364070
98MP0001270_distended_abdomen1.01173931
99MP0003938_abnormal_ear_development1.00967842
100MP0002282_abnormal_trachea_morphology0.99860842
101MP0002295_abnormal_pulmonary_circulatio0.99709467
102MP0005423_abnormal_somatic_nervous0.98401117
103MP0002233_abnormal_nose_morphology0.97870791
104MP0000538_abnormal_urinary_bladder0.97224019
105MP0000003_abnormal_adipose_tissue0.97118976
106MP0002089_abnormal_postnatal_growth/wei0.97115767
107MP0002653_abnormal_ependyma_morphology0.96732281
108MP0003950_abnormal_plasma_membrane0.96096606
109MP0003283_abnormal_digestive_organ0.95175685
110MP0000462_abnormal_digestive_system0.95164676
111MP0002115_abnormal_skeleton_extremities0.92671414
112MP0003045_fibrosis0.90979541
113MP0001348_abnormal_lacrimal_gland0.90559195
114MP0002896_abnormal_bone_mineralization0.89327219
115MP0002116_abnormal_craniofacial_bone0.88940812
116MP0005508_abnormal_skeleton_morphology0.88604390
117MP0000467_abnormal_esophagus_morphology0.88505834
118MP0003755_abnormal_palate_morphology0.88316808
119MP0005409_darkened_coat_color0.87850924
120MP0000163_abnormal_cartilage_morphology0.86411414
121MP0002751_abnormal_autonomic_nervous0.86181991
122MP0002877_abnormal_melanocyte_morpholog0.85905033
123MP0005171_absent_coat_pigmentation0.85554353
124MP0002160_abnormal_reproductive_system0.85311520
125MP0002109_abnormal_limb_morphology0.84927287
126MP0005197_abnormal_uvea_morphology0.84240504
127MP0000920_abnormal_myelination0.83569123
128MP0003136_yellow_coat_color0.82370043
129MP0003861_abnormal_nervous_system0.81946716
130MP0002114_abnormal_axial_skeleton0.80896842
131MP0002152_abnormal_brain_morphology0.80223188
132MP0004133_heterotaxia0.79890671
133MP0002697_abnormal_eye_size0.78756451
134MP0010771_integument_phenotype0.78741568
135MP0003631_nervous_system_phenotype0.77656899
136MP0010030_abnormal_orbit_morphology0.77234150
137MP0002133_abnormal_respiratory_system0.77089686
138MP0005388_respiratory_system_phenotype0.77089686
139* MP0002066_abnormal_motor_capabilities/c0.76126861
140MP0005083_abnormal_biliary_tract0.76078458
141MP0000566_synostosis0.75966714
142MP0003634_abnormal_glial_cell0.75607682
143MP0003935_abnormal_craniofacial_develop0.73900660
144MP0002168_other_aberrant_phenotype0.71835380
145MP0004883_abnormal_blood_vessel0.71431297
146MP0003705_abnormal_hypodermis_morpholog0.70523827
147MP0004484_altered_response_of0.70119601
148MP0000569_abnormal_digit_pigmentation0.69520574
149MP0005595_abnormal_vascular_smooth0.69408425
150MP0002128_abnormal_blood_circulation0.69284340
151MP0002084_abnormal_developmental_patter0.67875240
152MP0002925_abnormal_cardiovascular_devel0.67566094
153MP0005390_skeleton_phenotype0.66870087
154MP0003878_abnormal_ear_physiology0.65814479
155MP0005377_hearing/vestibular/ear_phenot0.65814479
156MP0002113_abnormal_skeleton_development0.63425557
157MP0002177_abnormal_outer_ear0.63325670
158MP0001614_abnormal_blood_vessel0.63266268
159MP0002092_abnormal_eye_morphology0.62872735
160MP0005501_abnormal_skin_physiology0.61912276
161MP0001175_abnormal_lung_morphology0.60599041
162MP0002111_abnormal_tail_morphology0.59843779
163MP0001340_abnormal_eyelid_morphology0.59701118

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.60261335
2Abnormal respiratory epithelium morphology (HP:0012253)5.03899912
3Abnormal respiratory motile cilium morphology (HP:0005938)5.03899912
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.91419411
5Absent/shortened dynein arms (HP:0200106)4.91419411
6Abnormal respiratory motile cilium physiology (HP:0012261)4.83808496
7Ulnar claw (HP:0001178)4.83042543
8Abnormal ciliary motility (HP:0012262)4.79806947
9Abnormality of the parietal bone (HP:0002696)4.66607579
10Midline defect of the nose (HP:0004122)4.52287800
11Rhinitis (HP:0012384)4.51942689
12Short 4th metacarpal (HP:0010044)4.39518942
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.39518942
14Action tremor (HP:0002345)4.17244274
15Abnormality of dentin (HP:0010299)3.98740512
16Vascular tortuosity (HP:0004948)3.95006418
17Aortic dissection (HP:0002647)3.93881772
18Insidious onset (HP:0003587)3.90877694
19Termporal pattern (HP:0011008)3.90877694
20Neonatal short-limb short stature (HP:0008921)3.87744596
21Aortic aneurysm (HP:0004942)3.82971458
22Soft skin (HP:0000977)3.67476398
23Ankle contracture (HP:0006466)3.53033361
24Trigonocephaly (HP:0000243)3.52502622
25Shallow orbits (HP:0000586)3.50051139
26Bladder diverticulum (HP:0000015)3.45331063
27Focal motor seizures (HP:0011153)3.38518119
28Follicular hyperkeratosis (HP:0007502)3.38386069
29Arterial tortuosity (HP:0005116)3.36210435
30Neoplasm of the heart (HP:0100544)3.32004480
31Aplasia involving bones of the extremities (HP:0009825)3.26381851
32Aplasia involving bones of the upper limbs (HP:0009823)3.26381851
33Aplasia of the phalanges of the hand (HP:0009802)3.26381851
34Cervical subluxation (HP:0003308)3.22574598
35Broad metatarsal (HP:0001783)3.17418340
36Chronic bronchitis (HP:0004469)3.14962480
37Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.11487413
38Segmental peripheral demyelination/remyelination (HP:0003481)3.09186612
39Abnormality of the 4th metacarpal (HP:0010012)3.06276688
40Myokymia (HP:0002411)3.04971359
41Nasal polyposis (HP:0100582)3.01737569
42Abnormality of the diencephalon (HP:0010662)2.96719143
43Focal seizures (HP:0007359)2.87630150
44Bronchiectasis (HP:0002110)2.86084753
45Bell-shaped thorax (HP:0001591)2.75189651
46Type 1 muscle fiber predominance (HP:0003803)2.74787597
47Wormian bones (HP:0002645)2.72058233
48Nasolacrimal duct obstruction (HP:0000579)2.71655726
49Spinal rigidity (HP:0003306)2.70242348
50Alacrima (HP:0000522)2.68028249
51Abnormality of the nasal mucosa (HP:0000433)2.66880172
52Bowel diverticulosis (HP:0005222)2.66282510
53Bronchomalacia (HP:0002780)2.65669709
54Abnormality of the nasal septum (HP:0000419)2.60196894
55Biconcave vertebral bodies (HP:0004586)2.58353607
56Morphological abnormality of the middle ear (HP:0008609)2.57245909
57Hypoventilation (HP:0002791)2.53074428
58Wide anterior fontanel (HP:0000260)2.52472661
59Aortic regurgitation (HP:0001659)2.50790726
60Visual hallucinations (HP:0002367)2.50402023
61Atelectasis (HP:0100750)2.46720765
62Mild short stature (HP:0003502)2.44964417
63Protrusio acetabuli (HP:0003179)2.43896178
64Toxemia of pregnancy (HP:0100603)2.43044418
65Large earlobe (HP:0009748)2.42638166
66Absent frontal sinuses (HP:0002688)2.41191438
67Breech presentation (HP:0001623)2.40376101
68Short phalanx of the thumb (HP:0009660)2.40296523
69Broad face (HP:0000283)2.39742717
70Ulnar bowing (HP:0003031)2.38337883
71Dilatation of the ascending aorta (HP:0005111)2.36868434
72Atrophic scars (HP:0001075)2.35728060
73Joint laxity (HP:0001388)2.35559085
74Atonic seizures (HP:0010819)2.30822680
75Blue sclerae (HP:0000592)2.30153920
76Microglossia (HP:0000171)2.30059763
77Milia (HP:0001056)2.29068935
78Mildly elevated creatine phosphokinase (HP:0008180)2.22694281
79Abnormality of the labia minora (HP:0012880)2.21884921
80Anteriorly placed anus (HP:0001545)2.21817859
81Abnormality of the distal phalanx of the thumb (HP:0009617)2.21316222
82Aplasia cutis congenita (HP:0001057)2.20945054
83Epileptic encephalopathy (HP:0200134)2.20400560
84Abnormality of the nasolacrimal system (HP:0000614)2.18340958
85Polyphagia (HP:0002591)2.18061872
86Impaired proprioception (HP:0010831)2.17549449
87Abnormality of the lacrimal duct (HP:0011481)2.17547372
88Occipital encephalocele (HP:0002085)2.16109265
89Infantile muscular hypotonia (HP:0008947)2.14505604
90Abnormality of the acetabulum (HP:0003170)2.14216069
91Blue irides (HP:0000635)2.14063068
92Slender build (HP:0001533)2.13708910
93Down-sloping shoulders (HP:0200021)2.12268438
94Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.10438711
95Concave nail (HP:0001598)2.09811191
96Narrow palate (HP:0000189)2.09276982
97Buphthalmos (HP:0000557)2.09194314
98Mitral regurgitation (HP:0001653)2.07727804
99Exostoses (HP:0100777)2.05312733
100Decreased lacrimation (HP:0000633)2.04710677
101Elbow flexion contracture (HP:0002987)2.03841070
102Bilateral microphthalmos (HP:0007633)2.02739403
103Neoplasm of the oral cavity (HP:0100649)2.02612876
104Hammertoe (HP:0001765)2.01987401
105Abnormal delivery (HP:0001787)2.01078621
106Heterochromia iridis (HP:0001100)2.00645237
107Male infertility (HP:0003251)2.00354046
108Supernumerary ribs (HP:0005815)1.99804820
109Turricephaly (HP:0000262)1.99359691
110Febrile seizures (HP:0002373)1.98935739
111Short nail (HP:0001799)1.98491069
112Aqueductal stenosis (HP:0002410)1.98309238
113Coronal craniosynostosis (HP:0004440)1.98175535
114Natal tooth (HP:0000695)1.97636752
115Long toe (HP:0010511)1.96486218
116Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96186029
117Abnormality of the frontal sinuses (HP:0002687)1.91917932
118Steppage gait (HP:0003376)1.91841990
119Upper limb muscle weakness (HP:0003484)1.90229668
120Onion bulb formation (HP:0003383)1.89625130
121Generalized tonic-clonic seizures (HP:0002069)1.88659772
122Progressive cerebellar ataxia (HP:0002073)1.87446151
123Premature rupture of membranes (HP:0001788)1.87442075
124Deviation of the hallux (HP:0010051)1.86517942
125Postural tremor (HP:0002174)1.85540811
126Spondylolisthesis (HP:0003302)1.84907852
127Humeroradial synostosis (HP:0003041)1.84038106
128Synostosis involving the elbow (HP:0003938)1.84038106
129Hyperextensible skin (HP:0000974)1.83790697
130Aplasia of the musculature (HP:0100854)1.83062127
131Excessive salivation (HP:0003781)1.82617125
132Drooling (HP:0002307)1.82617125
133Megalencephaly (HP:0001355)1.82036066
134Infertility (HP:0000789)1.80922569
135Broad hallux (HP:0010055)1.79908325
136Hallux valgus (HP:0001822)1.78772316
137Overgrowth (HP:0001548)1.78219063
138Fragile skin (HP:0001030)1.78073720
139Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77681579
140Amblyopia (HP:0000646)1.77655109
141Depressed nasal tip (HP:0000437)1.76865913
142Broad toe (HP:0001837)1.76864710
143Mesomelia (HP:0003027)1.76151055
144Cerebral inclusion bodies (HP:0100314)1.76090888
145Absence seizures (HP:0002121)1.75976117
146Increased CSF protein (HP:0002922)1.75827620
147Genu recurvatum (HP:0002816)1.75631247
148Upper limb amyotrophy (HP:0009129)1.75424521
149Distal upper limb amyotrophy (HP:0007149)1.75424521
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.74126497
151Abnormal number of incisors (HP:0011064)1.73912333
152Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.73796386
153Aneurysm (HP:0002617)1.71534259
154Mitral valve prolapse (HP:0001634)1.70540879
155Nonimmune hydrops fetalis (HP:0001790)1.70434452
156Hand muscle atrophy (HP:0009130)1.70280276
157Supernumerary bones of the axial skeleton (HP:0009144)1.69829876
158Partial duplication of the phalanx of hand (HP:0009999)1.69303696
159Abnormal eating behavior (HP:0100738)1.68791274
160Hypoplasia of the maxilla (HP:0000327)1.67200345
161Femoral bowing (HP:0002980)1.66805322
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.66320427
163Osteolytic defects of the hand bones (HP:0009699)1.66320427
164Peripheral hypomyelination (HP:0007182)1.65234033
165Papilledema (HP:0001085)1.64938515
166Ankle clonus (HP:0011448)1.64872840
167Peritonitis (HP:0002586)1.64507247
168Asymmetry of the thorax (HP:0001555)1.63848108
169Abnormality of the vocal cords (HP:0008777)1.63716234
170Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.63480208
171Protruding ear (HP:0000411)1.61089260
172Hip contracture (HP:0003273)1.60912938
173Vertebral arch anomaly (HP:0008438)1.60518109
174Vertebral compression fractures (HP:0002953)1.60135397
175Bowing of the arm (HP:0006488)1.59540032
176Bowed forearm bones (HP:0003956)1.59540032
177Abnormality of the distal phalanges of the toes (HP:0010182)1.58187550
178Inguinal hernia (HP:0000023)1.56582208
179Knee flexion contracture (HP:0006380)1.56294430
180Calcaneovalgus deformity (HP:0001848)1.56146284
181Aortic valve stenosis (HP:0001650)1.56016001
182Increased variability in muscle fiber diameter (HP:0003557)1.55965924
183Cerebral aneurysm (HP:0004944)1.54984329
184Deformed tarsal bones (HP:0008119)1.52670127
185Obstructive sleep apnea (HP:0002870)1.51754145
186Limb-girdle muscle weakness (HP:0003325)1.51083588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.21587013
2MAP3K93.85016384
3TIE13.42791661
4EPHA43.34189509
5MYLK3.22583405
6NTRK33.21539618
7MARK12.97385990
8AKT32.90393642
9LATS22.78454619
10EPHA22.57386757
11MAP3K42.54150907
12FGFR22.41028042
13RIPK42.37484955
14MINK12.26799351
15MET2.11222476
16KSR22.10531914
17NEK92.06590133
18CAMK1G2.03400938
19PNCK1.94981103
20DDR21.80041920
21PLK21.78545491
22SIK21.76682389
23CDK121.72583698
24ICK1.69907150
25PRKD31.68708082
26PAK61.68022757
27DAPK21.67460341
28BMX1.64724171
29MAP2K71.62654275
30KSR11.62504530
31MAP3K121.62433518
32PAK21.57682877
33MAP3K131.57275067
34MST1R1.55319790
35CAMK1D1.54431857
36NTRK11.50806803
37MAP2K41.47300660
38TYRO31.42613008
39TTN1.40192220
40STK38L1.38642162
41RET1.36142307
42MAPK131.34801892
43PRKD21.33423483
44EEF2K1.30023781
45CDC42BPA1.28828234
46TESK11.27029027
47CDK51.26138792
48MARK21.21873835
49MAP3K21.21594480
50ARAF1.20174268
51NTRK21.14223152
52FER1.10851371
53PAK31.07805275
54MTOR1.05097745
55GRK51.04273261
56ERBB41.03175614
57BMPR21.02770046
58CASK1.01379123
59FLT31.00264863
60PRKCG0.99819955
61PTK2B0.99764104
62CAMKK10.98366470
63TRPM70.98153987
64FGFR10.96462766
65PDGFRA0.94307464
66CSNK1G20.92560224
67ADRBK10.91708055
68PIK3CA0.90952710
69BCR0.90322365
70PIK3CG0.89589902
71RPS6KA20.89283860
72PAK40.87369922
73LATS10.87348845
74ROCK10.85683297
75UHMK10.84984270
76MAP3K70.84050125
77TRIB30.80179442
78RAF10.79110271
79DAPK10.78506284
80STK30.78079684
81MST40.77064821
82DYRK1B0.76181560
83BRD40.76120703
84GRK60.75129322
85PRKCE0.74278716
86DMPK0.73365371
87MAP3K100.72391995
88PRKCH0.70615795
89TAOK10.68039354
90STK380.67991557
91MOS0.67213474
92DYRK1A0.66097123
93CAMK2A0.66068762
94CAMK10.65980116
95TTK0.65833260
96CSNK1A1L0.65399655
97MAP3K60.64607923
98SMG10.64509289
99STK390.64269926
100EPHA30.64125997
101EPHB20.63683530
102IRAK20.63302514
103PHKG10.63103689
104PHKG20.63103689
105SGK4940.62636900
106SGK2230.62636900
107NME10.61366629
108MAP2K10.60954839
109CDK140.60861004
110LMTK20.59733258
111CDK150.57989903
112CDK180.57167890
113MAPKAPK30.55646911
114PDGFRB0.55322021
115NEK20.54885694
116SGK30.54482708
117MELK0.53582154
118STK110.52206029
119CAMK40.51843969
120ILK0.51778958
121ABL20.50635196
122SIK10.50491012
123CAMK2G0.49924966
124GRK70.49841913
125MAPK70.49394763
126CDK60.49238770
127GSK3A0.49166817
128EPHB10.49143945
129PTK20.48987538
130LIMK10.48870079
131MAP3K10.47306247
132FYN0.46758140
133YES10.46439474
134SGK10.46014761
135PRKCI0.45675215
136CDK11A0.45375843
137MAP3K30.45018264
138SGK20.44592276
139ROCK20.44460806
140CAMK2B0.43893851
141CDK80.43555032
142MAPKAPK50.43450399
143RIPK10.42109773
144PRKCZ0.41515338
145RPS6KL10.41175579
146RPS6KC10.41175579
147GRK10.39711930
148PDPK10.37739061
149CDK190.37468395
150TGFBR20.37101535
151DYRK20.36174235
152WNK40.36140271
153WNK10.36110017
154PBK0.35400079
155SRC0.35038049
156PRKD10.34680098
157PKN20.34140120
158MAPK100.33817312
159ERN10.33253355
160IRAK10.33247053
161PIM20.33176548
162STK240.31705896
163RPS6KA60.29397749
164RPS6KB20.27764724
165CDK90.25901228
166ABL10.23129353
167CHEK20.22476280
168AURKA0.20039699

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049742.50699191
2Long-term potentiation_Homo sapiens_hsa047202.31202772
3Nicotine addiction_Homo sapiens_hsa050332.27525586
4Synaptic vesicle cycle_Homo sapiens_hsa047212.19839470
5Circadian entrainment_Homo sapiens_hsa047132.01091054
6Olfactory transduction_Homo sapiens_hsa047401.95976402
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90208197
8Amphetamine addiction_Homo sapiens_hsa050311.90182094
9Glutamatergic synapse_Homo sapiens_hsa047241.86735146
10Morphine addiction_Homo sapiens_hsa050321.82939432
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80608158
12Gastric acid secretion_Homo sapiens_hsa049711.80186465
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78559186
14Salivary secretion_Homo sapiens_hsa049701.77690980
15Hedgehog signaling pathway_Homo sapiens_hsa043401.72455562
16Renin secretion_Homo sapiens_hsa049241.70152951
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69671800
18Cholinergic synapse_Homo sapiens_hsa047251.67576899
19Axon guidance_Homo sapiens_hsa043601.62563417
20Dopaminergic synapse_Homo sapiens_hsa047281.61884639
21GABAergic synapse_Homo sapiens_hsa047271.60677042
22Gap junction_Homo sapiens_hsa045401.60371093
23GnRH signaling pathway_Homo sapiens_hsa049121.53764228
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50875472
25Basal cell carcinoma_Homo sapiens_hsa052171.49654393
26Melanogenesis_Homo sapiens_hsa049161.48044710
27Glioma_Homo sapiens_hsa052141.47167751
28Oxytocin signaling pathway_Homo sapiens_hsa049211.46861579
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46338393
30Estrogen signaling pathway_Homo sapiens_hsa049151.45582865
31MicroRNAs in cancer_Homo sapiens_hsa052061.44621575
32Insulin secretion_Homo sapiens_hsa049111.42001937
33Small cell lung cancer_Homo sapiens_hsa052221.41746593
34Long-term depression_Homo sapiens_hsa047301.39545297
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35473621
36ErbB signaling pathway_Homo sapiens_hsa040121.34371619
37Taste transduction_Homo sapiens_hsa047421.31597489
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.31276221
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28603370
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28579603
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27482008
42Dilated cardiomyopathy_Homo sapiens_hsa054141.25329571
43Bladder cancer_Homo sapiens_hsa052191.24149035
44Wnt signaling pathway_Homo sapiens_hsa043101.23991389
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23263428
46Serotonergic synapse_Homo sapiens_hsa047261.23032308
47Calcium signaling pathway_Homo sapiens_hsa040201.22374711
48ECM-receptor interaction_Homo sapiens_hsa045121.20882566
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20274207
50cAMP signaling pathway_Homo sapiens_hsa040241.20010327
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19116433
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17703838
53Cocaine addiction_Homo sapiens_hsa050301.13687645
54Chronic myeloid leukemia_Homo sapiens_hsa052201.11529357
55Notch signaling pathway_Homo sapiens_hsa043301.09376459
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08709437
57Prostate cancer_Homo sapiens_hsa052151.07937477
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06513997
59Rap1 signaling pathway_Homo sapiens_hsa040151.05549645
60Melanoma_Homo sapiens_hsa052181.04646899
61VEGF signaling pathway_Homo sapiens_hsa043701.01033178
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97378613
63Endometrial cancer_Homo sapiens_hsa052130.96273081
64Colorectal cancer_Homo sapiens_hsa052100.96100332
65Sphingolipid metabolism_Homo sapiens_hsa006000.95736062
66Type II diabetes mellitus_Homo sapiens_hsa049300.92586393
67Phenylalanine metabolism_Homo sapiens_hsa003600.92369264
68Focal adhesion_Homo sapiens_hsa045100.91163388
69Dorso-ventral axis formation_Homo sapiens_hsa043200.91078167
70Histidine metabolism_Homo sapiens_hsa003400.91014307
71MAPK signaling pathway_Homo sapiens_hsa040100.87691955
72Ras signaling pathway_Homo sapiens_hsa040140.87683370
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87571299
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.87251238
75p53 signaling pathway_Homo sapiens_hsa041150.83614485
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.83582916
77Collecting duct acid secretion_Homo sapiens_hsa049660.82906502
78Amoebiasis_Homo sapiens_hsa051460.82839801
79Oocyte meiosis_Homo sapiens_hsa041140.82821345
80Adherens junction_Homo sapiens_hsa045200.81965181
81Thyroid hormone synthesis_Homo sapiens_hsa049180.81799617
82Choline metabolism in cancer_Homo sapiens_hsa052310.81290575
83Tyrosine metabolism_Homo sapiens_hsa003500.80747912
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80593144
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80327178
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.79812247
87Hippo signaling pathway_Homo sapiens_hsa043900.79153100
88Chemical carcinogenesis_Homo sapiens_hsa052040.79004783
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.78995236
90Proteoglycans in cancer_Homo sapiens_hsa052050.78146569
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75345904
92Renal cell carcinoma_Homo sapiens_hsa052110.74174216
93Pancreatic cancer_Homo sapiens_hsa052120.73543392
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70160596
95Vibrio cholerae infection_Homo sapiens_hsa051100.69397165
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67771131
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67408881
98Pathways in cancer_Homo sapiens_hsa052000.67323027
99Non-small cell lung cancer_Homo sapiens_hsa052230.66979778
100Thyroid cancer_Homo sapiens_hsa052160.65739910
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64378772
102mTOR signaling pathway_Homo sapiens_hsa041500.64008769
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.63218884
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62957598
105TGF-beta signaling pathway_Homo sapiens_hsa043500.62411531
106N-Glycan biosynthesis_Homo sapiens_hsa005100.62366876
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61519298
108Ovarian steroidogenesis_Homo sapiens_hsa049130.61512872
109Endocytosis_Homo sapiens_hsa041440.61139007
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.59865886
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59082699
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58911554
113African trypanosomiasis_Homo sapiens_hsa051430.58756754
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57728867
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57064444
116Pancreatic secretion_Homo sapiens_hsa049720.56443534
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56116372
118Glucagon signaling pathway_Homo sapiens_hsa049220.55285330
119HIF-1 signaling pathway_Homo sapiens_hsa040660.54720829
120Inositol phosphate metabolism_Homo sapiens_hsa005620.54401569
121AMPK signaling pathway_Homo sapiens_hsa041520.53773869
122Renin-angiotensin system_Homo sapiens_hsa046140.53218982
123Tight junction_Homo sapiens_hsa045300.52938545
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52882003
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52456538
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51722607
127Platelet activation_Homo sapiens_hsa046110.51650570
128Alcoholism_Homo sapiens_hsa050340.51219813
129Prion diseases_Homo sapiens_hsa050200.50359302
130Prolactin signaling pathway_Homo sapiens_hsa049170.49086232
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48683960
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45809821
133Insulin signaling pathway_Homo sapiens_hsa049100.41162375
134Hepatitis C_Homo sapiens_hsa051600.38637862

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