PRSS16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host (GO:0044406)9.09271806
2antigen processing and presentation of endogenous antigen (GO:0019883)8.49312285
3hemidesmosome assembly (GO:0031581)8.34791567
4cellular response to interferon-alpha (GO:0035457)7.92506120
5regulation of cellular extravasation (GO:0002691)7.76840584
6bundle of His cell to Purkinje myocyte communication (GO:0086069)7.40038829
7collecting duct development (GO:0072044)6.79597604
8negative regulation of activin receptor signaling pathway (GO:0032926)6.73785114
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.62049940
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.62049940
11positive regulation of natural killer cell differentiation (GO:0032825)6.58206259
12negative regulation of fibroblast apoptotic process (GO:2000270)5.77858875
13negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)5.58410545
14cellular response to vitamin (GO:0071295)5.44126138
15response to interferon-alpha (GO:0035455)5.42748671
16thymus development (GO:0048538)5.36590261
17cytokine production involved in immune response (GO:0002367)5.21020128
18desmosome organization (GO:0002934)5.09774907
19proline transport (GO:0015824)4.93081870
20peptidyl-glutamic acid carboxylation (GO:0017187)4.90602021
21protein carboxylation (GO:0018214)4.90602021
22proteasome assembly (GO:0043248)4.77610649
23bone morphogenesis (GO:0060349)4.59335610
24DNA replication checkpoint (GO:0000076)4.58999514
25regulation of glomerular filtration (GO:0003093)4.58459580
26regulation of transforming growth factor beta2 production (GO:0032909)4.56432972
27extracellular matrix assembly (GO:0085029)4.49749688
28negative regulation of leukocyte apoptotic process (GO:2000107)4.34858856
29alanine transport (GO:0032328)4.32613110
30regulation of natural killer cell differentiation (GO:0032823)4.29314347
31hepatocyte apoptotic process (GO:0097284)4.27218826
32regulation of secondary heart field cardioblast proliferation (GO:0003266)4.23471937
33regulation of cardioblast proliferation (GO:0003264)4.23471937
34DNA double-strand break processing (GO:0000729)4.20348381
35negative regulation of T cell apoptotic process (GO:0070233)4.18345381
36epithelial cell fate commitment (GO:0072148)3.97611316
37apoptotic cell clearance (GO:0043277)3.97060194
38glycine transport (GO:0015816)3.93885735
39negative regulation of leukocyte migration (GO:0002686)3.92840685
40negative regulation of biomineral tissue development (GO:0070168)3.86506391
41positive regulation of protein export from nucleus (GO:0046827)3.85774206
42mesenchymal cell differentiation involved in renal system development (GO:2001012)3.82259817
43mesenchymal cell differentiation involved in kidney development (GO:0072161)3.82259817
44negative regulation of interleukin-1 production (GO:0032692)3.68844814
45CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.67757843
46negative regulation of lymphocyte apoptotic process (GO:0070229)3.64018760
47renal system process involved in regulation of blood volume (GO:0001977)3.62749583
48DNA strand elongation involved in DNA replication (GO:0006271)3.59781620
49thymic T cell selection (GO:0045061)3.55728229
50cellular response to thyroid hormone stimulus (GO:0097067)3.55516991
51positive regulation of macrophage cytokine production (GO:0060907)3.52953946
52L-serine metabolic process (GO:0006563)3.49735359
53telomere maintenance via semi-conservative replication (GO:0032201)3.49603366
54regulation of protein import into nucleus, translocation (GO:0033158)3.47494301
55cell-substrate junction assembly (GO:0007044)3.47058316
56mitotic sister chromatid cohesion (GO:0007064)3.46414588
57ribosome assembly (GO:0042255)3.46027518
58production of molecular mediator of immune response (GO:0002440)3.43919883
59DNA strand elongation (GO:0022616)3.43001002
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.33761142
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33761142
62kinetochore organization (GO:0051383)3.33310962
63aorta morphogenesis (GO:0035909)3.31348238
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.29660216
65positive regulation of hormone biosynthetic process (GO:0046886)3.28434800
66CD4-positive, alpha-beta T cell activation (GO:0035710)3.28268993
67replication fork processing (GO:0031297)3.25830456
68gland morphogenesis (GO:0022612)3.24897657
69positive regulation of cytokine-mediated signaling pathway (GO:0001961)3.24868324
70regulation of fibroblast apoptotic process (GO:2000269)3.22330144
71amino acid activation (GO:0043038)3.20922785
72tRNA aminoacylation (GO:0043039)3.20922785
73tRNA aminoacylation for protein translation (GO:0006418)3.20683887
74ventricular cardiac muscle cell action potential (GO:0086005)3.19501084
75transcription from mitochondrial promoter (GO:0006390)3.18855537
76cell differentiation involved in metanephros development (GO:0072202)3.18506967
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17904464
78positive regulation of endothelial cell apoptotic process (GO:2000353)3.16969169
79establishment of integrated proviral latency (GO:0075713)3.16637127
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16307530
81mitochondrial RNA metabolic process (GO:0000959)3.15701650
82skin development (GO:0043588)3.15042258
83kinetochore assembly (GO:0051382)3.13774225
84protein localization to kinetochore (GO:0034501)3.13301624
85rRNA modification (GO:0000154)3.09369928
86telomere maintenance via recombination (GO:0000722)3.08728661
87apoptotic process involved in morphogenesis (GO:0060561)3.08482922
88viral entry into host cell (GO:0046718)3.07267532
89Notch receptor processing (GO:0007220)3.06531839
90protein targeting to plasma membrane (GO:0072661)3.06212068
91response to type I interferon (GO:0034340)3.05768634
92epithelial cell morphogenesis (GO:0003382)3.04972099
93formation of translation preinitiation complex (GO:0001731)3.04950430
94mitotic nuclear envelope disassembly (GO:0007077)3.04024204
95pseudouridine synthesis (GO:0001522)3.03895893
96mitotic metaphase plate congression (GO:0007080)3.03482144
97respiratory system process (GO:0003016)3.02737736
98DNA catabolic process, exonucleolytic (GO:0000738)3.02536136
99cellular response to nutrient (GO:0031670)3.01692230
100anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00903251
101type I interferon signaling pathway (GO:0060337)3.00333015
102cellular response to type I interferon (GO:0071357)3.00333015
103positive regulation of response to cytokine stimulus (GO:0060760)3.00325408
104CENP-A containing nucleosome assembly (GO:0034080)2.99362122
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.98111525
106branching involved in labyrinthine layer morphogenesis (GO:0060670)2.98026642
107chromatin remodeling at centromere (GO:0031055)2.97981133
108positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97273458
109peptidyl-histidine modification (GO:0018202)2.96316160
110Notch signaling involved in heart development (GO:0061314)2.95760564
111respiratory chain complex IV assembly (GO:0008535)2.95629442
112endodermal cell differentiation (GO:0035987)2.95178604
113mesenchyme development (GO:0060485)2.94496696
114rRNA methylation (GO:0031167)2.94060357
115regulation of mitotic spindle checkpoint (GO:1903504)2.92723770
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92723770
117renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.90218780
118regulation of protein export from nucleus (GO:0046825)2.89250522
119meiotic chromosome segregation (GO:0045132)2.88470580
120endothelial tube morphogenesis (GO:0061154)2.87614058
121morphogenesis of an endothelium (GO:0003159)2.87614058
122negative regulation of ligase activity (GO:0051352)2.87367930
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87367930
124telomere maintenance via telomere lengthening (GO:0010833)2.87132192
125purine nucleobase biosynthetic process (GO:0009113)2.85669262
126telomere maintenance via telomerase (GO:0007004)2.85628647
127corticosteroid receptor signaling pathway (GO:0031958)2.84018054
128synapsis (GO:0007129)2.83731354
129mitotic recombination (GO:0006312)2.83414955
130cell communication involved in cardiac conduction (GO:0086065)2.82729598
131positive regulation of embryonic development (GO:0040019)2.82513487
132pteridine-containing compound biosynthetic process (GO:0042559)2.82077267
133DNA ligation (GO:0006266)2.82045897
134nucleobase biosynthetic process (GO:0046112)2.81761742
135DNA replication initiation (GO:0006270)2.81704737
136regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.81310296
137non-recombinational repair (GO:0000726)2.80197778
138double-strand break repair via nonhomologous end joining (GO:0006303)2.80197778
139middle ear morphogenesis (GO:0042474)2.79698441
140nuclear pore complex assembly (GO:0051292)2.78782746
141positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78078854
142regulation of somitogenesis (GO:0014807)2.77753387
143IMP biosynthetic process (GO:0006188)2.76845113
144folic acid-containing compound biosynthetic process (GO:0009396)2.75302239
145transcription elongation from RNA polymerase III promoter (GO:0006385)2.75027345
146termination of RNA polymerase III transcription (GO:0006386)2.75027345
147regulation of translational fidelity (GO:0006450)2.74871158
148maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74683776
149protein K6-linked ubiquitination (GO:0085020)2.74411568
150lymphocyte chemotaxis (GO:0048247)2.72943066
151regulation of cellular amino acid metabolic process (GO:0006521)2.70701955
152epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70243972
153regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.70205579
154regulation of endothelial cell apoptotic process (GO:2000351)2.69642744
155positive regulation of ligase activity (GO:0051351)2.69547175
156mitotic sister chromatid segregation (GO:0000070)2.69174477
157serine family amino acid biosynthetic process (GO:0009070)2.68722492
158metaphase plate congression (GO:0051310)2.68393852
159myoblast migration (GO:0051451)2.68186129
160positive regulation of chromosome segregation (GO:0051984)2.66626672
161semaphorin-plexin signaling pathway (GO:0071526)2.66196694
162keratinocyte development (GO:0003334)2.65553344
163maturation of 5.8S rRNA (GO:0000460)2.65341679
164receptor catabolic process (GO:0032801)2.64918086
165growth hormone receptor signaling pathway (GO:0060396)2.64769271
166viral mRNA export from host cell nucleus (GO:0046784)2.64298905
167membrane disassembly (GO:0030397)2.64100000
168nuclear envelope disassembly (GO:0051081)2.64100000
169histone exchange (GO:0043486)2.61919542
170nuclear pore organization (GO:0006999)2.60981999
171regulation of ubiquitin-protein transferase activity (GO:0051438)2.60776873
172nephron tubule formation (GO:0072079)2.60440081
173fat-soluble vitamin biosynthetic process (GO:0042362)2.60149698
174transcription elongation from RNA polymerase I promoter (GO:0006362)2.59402622
175leukocyte apoptotic process (GO:0071887)2.58541105
176nucleotide-excision repair, DNA gap filling (GO:0006297)2.57886882
177regulation of helicase activity (GO:0051095)2.57541783
178dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.57482091
179cytochrome complex assembly (GO:0017004)2.56965245
180T cell proliferation (GO:0042098)2.56635467
181signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55099544
182signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55099544
183signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55099544
184negative regulation of DNA-dependent DNA replication (GO:2000104)2.54549705
185intestinal epithelial cell development (GO:0060576)2.54406997
186regulation of ligase activity (GO:0051340)2.54329463
187DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53398056
188spindle checkpoint (GO:0031577)2.52485092
189intra-S DNA damage checkpoint (GO:0031573)2.52382000
190water-soluble vitamin biosynthetic process (GO:0042364)2.52237890
191nucleotide-sugar biosynthetic process (GO:0009226)2.51919586
192double-strand break repair via homologous recombination (GO:0000724)2.51746079
193DNA replication-dependent nucleosome organization (GO:0034723)2.51553278
194DNA replication-dependent nucleosome assembly (GO:0006335)2.51553278
195signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51375732
196intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51375732
197adhesion of symbiont to host cell (GO:0044650)11.0721984
198virion attachment to host cell (GO:0019062)11.0721984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.24016708
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.81322478
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.72015041
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.71937864
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.79489378
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.77089105
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42473922
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34887344
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.32677221
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.26866519
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.25793730
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.25020944
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.10224995
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97693252
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.89547080
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.70521234
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60718477
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56189179
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.55934211
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.54324455
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.50678901
22ELK1_19687146_ChIP-ChIP_HELA_Human2.50619832
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49568997
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49471670
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32185375
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31354883
27ZNF263_19887448_ChIP-Seq_K562_Human2.25754012
28CLOCK_20551151_ChIP-Seq_293T_Human2.24165515
29* SALL1_21062744_ChIP-ChIP_HESCs_Human2.23860655
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14088252
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13110997
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11524237
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10537672
34PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09891730
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07350208
36SOX9_24532713_ChIP-Seq_HFSC_Mouse2.05648238
37AR_21572438_ChIP-Seq_LNCaP_Human2.04323884
38DCP1A_22483619_ChIP-Seq_HELA_Human2.03242199
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98845458
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98280400
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.95362682
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93279255
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91965943
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.91409593
45VDR_23849224_ChIP-Seq_CD4+_Human1.91187761
46FOXP3_21729870_ChIP-Seq_TREG_Human1.89509358
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89369004
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89179601
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81777631
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79804969
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79410210
52VDR_22108803_ChIP-Seq_LS180_Human1.79068256
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76440257
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.75426150
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74887757
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73522439
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68898019
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67347908
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.66828602
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65992221
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64916468
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63918357
63TTF2_22483619_ChIP-Seq_HELA_Human1.63233822
64RACK7_27058665_Chip-Seq_MCF-7_Human1.59840628
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59313548
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56571066
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54925568
68AR_21909140_ChIP-Seq_LNCAP_Human1.54133900
69GABP_19822575_ChIP-Seq_HepG2_Human1.53349893
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51838118
71KDM5A_27292631_Chip-Seq_BREAST_Human1.50871254
72MYC_18940864_ChIP-ChIP_HL60_Human1.49953672
73VDR_21846776_ChIP-Seq_THP-1_Human1.49509081
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49239878
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48123933
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.47671316
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.46231093
78XRN2_22483619_ChIP-Seq_HELA_Human1.45795271
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45415115
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45271474
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45102187
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42903687
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42548288
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42542214
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40640603
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40343976
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.39891322
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.38846625
89EWS_26573619_Chip-Seq_HEK293_Human1.36458267
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36306142
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35391849
92KDM2B_26808549_Chip-Seq_DND41_Human1.34527892
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33976268
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.33647880
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31835234
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28676312
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28427071
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28427071
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27894734
100* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27447452
101ELF5_23300383_ChIP-Seq_T47D_Human1.27357207
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27174634
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24908480
104SOX2_20726797_ChIP-Seq_SW620_Human1.24827005
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.24653074
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23977174
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23657474
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23011600
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22753833
110* TCF7_22412390_ChIP-Seq_EML_Mouse1.21856595
111TP53_16413492_ChIP-PET_HCT116_Human1.20509683
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20429954
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20352089
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19945515
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18784763
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18615794
117LXR_22292898_ChIP-Seq_THP-1_Human1.18158513
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17542243
119ELK3_25401928_ChIP-Seq_HUVEC_Human1.15683003
120LXR_22158963_ChIP-Seq_LIVER_Mouse1.15679616
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15138587
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.14970578
123RNF2_27304074_Chip-Seq_ESCs_Mouse1.14206037
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13883054
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12018316
126KDM2B_26808549_Chip-Seq_K562_Human1.10946986
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10854433
128FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10758678
129* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09835124
130YY1_21170310_ChIP-Seq_MESCs_Mouse1.08566001
131GATA6_25053715_ChIP-Seq_YYC3_Human1.08316804
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07686128
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07483119
134EED_16625203_ChIP-ChIP_MESCs_Mouse1.07476497
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06771379
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04087019
137* CREB1_26743006_Chip-Seq_LNCaP_Human1.03756719
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03369241
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03369241
140MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03097040
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02167356
142ZNF274_21170338_ChIP-Seq_K562_Hela1.00812394
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00701654
144WT1_19549856_ChIP-ChIP_CCG9911_Human1.00500564
145CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99370985
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99334387
147MYC_22102868_ChIP-Seq_BL_Human0.99293789
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99034753
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98249850
150FUS_26573619_Chip-Seq_HEK293_Human0.97940012
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97729045
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96987121
153RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96787102
154CHD1_26751641_Chip-Seq_LNCaP_Human0.96332502
155SOX2_16153702_ChIP-ChIP_HESCs_Human0.95615709
156CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94313155
157TP63_22573176_ChIP-Seq_HFKS_Human0.93683255
158* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93186251
159TBX20_22328084_ChIP-Seq_HEART_Mouse0.93161530
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.93161530
161CJUN_26792858_Chip-Seq_BT549_Human0.92853143
162* RING1B_27294783_Chip-Seq_ESCs_Mouse0.92370991
163ELK1_22589737_ChIP-Seq_MCF10A_Human0.91977572
164EZH2_22144423_ChIP-Seq_EOC_Human0.91837268
165TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90703165
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89263279
167* GATA3_24758297_ChIP-Seq_MCF-7_Human0.88884320
168CDX2_20551321_ChIP-Seq_CACO-2_Human0.88719206
169ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88491827
170MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88305897
171TP53_23651856_ChIP-Seq_MEFs_Mouse0.88037153
172* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87635517
173GATA4_25053715_ChIP-Seq_YYC3_Human0.87057159
174PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86878363
175POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84916467
176RBPJ_21746931_ChIP-Seq_IB4_Human0.84861991
177FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84239965
178EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83775258
179CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81256388
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80616892
181TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79719222
182SOX17_20123909_ChIP-Seq_XEN_Mouse0.79221742
183PHF8_20622853_ChIP-Seq_HELA_Human0.77251644
184EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75673869
185SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75540908
186HOXB7_26014856_ChIP-Seq_BT474_Human0.75421485
187ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75253886
188CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74115725
189NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72052054
190* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71878047
191* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71686866
192POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71024301
193PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.70558866
194KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.70300395
195KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.70300395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.69690784
2MP0000516_abnormal_urinary_system6.13746081
3MP0005367_renal/urinary_system_phenotyp6.13746081
4MP0003693_abnormal_embryo_hatching4.51197543
5MP0001346_abnormal_lacrimal_gland4.39038927
6MP0008058_abnormal_DNA_repair3.61537587
7MP0003453_abnormal_keratinocyte_physiol3.58248051
8MP0010094_abnormal_chromosome_stability3.51643908
9MP0004957_abnormal_blastocyst_morpholog3.48327922
10MP0000383_abnormal_hair_follicle3.37434146
11MP0002938_white_spotting3.34059803
12MP0003718_maternal_effect3.22269710
13MP0009278_abnormal_bone_marrow3.19948246
14MP0010678_abnormal_skin_adnexa2.96096942
15MP0003111_abnormal_nucleus_morphology2.85130267
16MP0002234_abnormal_pharynx_morphology2.66313054
17MP0001849_ear_inflammation2.63465646
18MP0008057_abnormal_DNA_replication2.61817730
19MP0002098_abnormal_vibrissa_morphology2.43932333
20MP0000733_abnormal_muscle_development2.41914064
21MP0010234_abnormal_vibrissa_follicle2.40640167
22MP0005023_abnormal_wound_healing2.20324383
23MP0010352_gastrointestinal_tract_polyps2.20171294
24MP0008932_abnormal_embryonic_tissue2.13299488
25MP0003077_abnormal_cell_cycle2.13009612
26MP0003786_premature_aging2.00525112
27MP0009697_abnormal_copulation1.99633121
28MP0008877_abnormal_DNA_methylation1.95009730
29MP0004147_increased_porphyrin_level1.91378973
30MP0008007_abnormal_cellular_replicative1.85945607
31MP0004264_abnormal_extraembryonic_tissu1.84182005
32MP0005623_abnormal_meninges_morphology1.78686069
33MP0003303_peritoneal_inflammation1.78565145
34MP0000685_abnormal_immune_system1.73125528
35MP0010030_abnormal_orbit_morphology1.68000910
36MP0009250_abnormal_appendicular_skeleto1.63374730
37MP0000372_irregular_coat_pigmentation1.62159550
38MP0000762_abnormal_tongue_morphology1.54827310
39MP0004782_abnormal_surfactant_physiolog1.53957213
40MP0001270_distended_abdomen1.52195246
41MP0003806_abnormal_nucleotide_metabolis1.51607693
42MP0000467_abnormal_esophagus_morphology1.51049065
43MP0002932_abnormal_joint_morphology1.45840645
44MP0008995_early_reproductive_senescence1.45757996
45MP0000613_abnormal_salivary_gland1.44759699
46MP0001730_embryonic_growth_arrest1.42333182
47MP0004272_abnormal_basement_membrane1.41427214
48MP0005075_abnormal_melanosome_morpholog1.41242148
49MP0000681_abnormal_thyroid_gland1.40028574
50MP0005501_abnormal_skin_physiology1.39624033
51MP0000579_abnormal_nail_morphology1.37859466
52MP0003566_abnormal_cell_adhesion1.35848091
53MP0000538_abnormal_urinary_bladder1.34430556
54MP0006036_abnormal_mitochondrial_physio1.33108753
55MP0001764_abnormal_homeostasis1.32938086
56MP0002138_abnormal_hepatobiliary_system1.32351091
57MP0001835_abnormal_antigen_presentation1.32305796
58MP0005310_abnormal_salivary_gland1.29897613
59MP0002796_impaired_skin_barrier1.28693107
60MP0005395_other_phenotype1.26857720
61MP0002060_abnormal_skin_morphology1.22913219
62MP0001881_abnormal_mammary_gland1.22759867
63MP0000377_abnormal_hair_follicle1.22540909
64MP0001697_abnormal_embryo_size1.22002130
65MP0001545_abnormal_hematopoietic_system1.21873475
66MP0005397_hematopoietic_system_phenotyp1.21873475
67MP0005508_abnormal_skeleton_morphology1.21566910
68MP0009672_abnormal_birth_weight1.21126909
69MP0001666_abnormal_nutrient_absorption1.21026185
70MP0002177_abnormal_outer_ear1.20926406
71MP0000462_abnormal_digestive_system1.20761152
72MP0008789_abnormal_olfactory_epithelium1.20361621
73MP0004019_abnormal_vitamin_homeostasis1.19643186
74MP0004947_skin_inflammation1.17314865
75MP0000350_abnormal_cell_proliferation1.16598790
76MP0000427_abnormal_hair_cycle1.14893739
77MP0001188_hyperpigmentation1.14681862
78MP0001929_abnormal_gametogenesis1.14450930
79MP0000537_abnormal_urethra_morphology1.13616087
80MP0000647_abnormal_sebaceous_gland1.11925136
81MP0003300_gastrointestinal_ulcer1.11535862
82MP0005380_embryogenesis_phenotype1.11309128
83MP0001672_abnormal_embryogenesis/_devel1.11309128
84MP0003890_abnormal_embryonic-extraembry1.11153047
85MP0008872_abnormal_physiological_respon1.10979356
86MP0002210_abnormal_sex_determination1.10256720
87MP0006035_abnormal_mitochondrial_morpho1.10148601
88MP0003942_abnormal_urinary_system1.09083360
89* MP0000703_abnormal_thymus_morphology1.08754324
90MP0009379_abnormal_foot_pigmentation1.07687381
91MP0003186_abnormal_redox_activity1.07187176
92MP0003075_altered_response_to1.07051842
93MP0001145_abnormal_male_reproductive1.06807084
94MP0004043_abnormal_pH_regulation1.05513881
95MP0003724_increased_susceptibility_to1.03956697
96MP0001216_abnormal_epidermal_layer1.02485953
97MP0000428_abnormal_craniofacial_morphol1.02372366
98MP0005332_abnormal_amino_acid0.98765381
99MP0003195_calcinosis0.98079880
100MP0000653_abnormal_sex_gland0.97979136
101MP0002084_abnormal_developmental_patter0.97086526
102MP0003705_abnormal_hypodermis_morpholog0.96364667
103MP0000163_abnormal_cartilage_morphology0.95914150
104MP0010307_abnormal_tumor_latency0.95376799
105MP0002085_abnormal_embryonic_tissue0.95207091
106MP0002111_abnormal_tail_morphology0.94521336
107MP0002102_abnormal_ear_morphology0.94072601
108MP0009703_decreased_birth_body0.94002693
109MP0002080_prenatal_lethality0.93931487
110MP0001851_eye_inflammation0.93861383
111MP0005636_abnormal_mineral_homeostasis0.93478573
112MP0000631_abnormal_neuroendocrine_gland0.92311837
113MP0003984_embryonic_growth_retardation0.92102093
114MP0005646_abnormal_pituitary_gland0.90819692
115MP0010155_abnormal_intestine_physiology0.90319877
116MP0002088_abnormal_embryonic_growth/wei0.90041618
117MP0003119_abnormal_digestive_system0.87248105
118MP0003755_abnormal_palate_morphology0.86156925
119MP0001348_abnormal_lacrimal_gland0.85199562
120MP0001853_heart_inflammation0.84481895
121MP0002736_abnormal_nociception_after0.84431011
122MP0004510_myositis0.84041540
123MP0005410_abnormal_fertilization0.83836099
124MP0002233_abnormal_nose_morphology0.82145291
125MP0001485_abnormal_pinna_reflex0.82092543
126MP0003698_abnormal_male_reproductive0.81584266
127MP0001293_anophthalmia0.81158426
128MP0001340_abnormal_eyelid_morphology0.80884979
129MP0000313_abnormal_cell_death0.79061258
130MP0000627_abnormal_mammary_gland0.78412355
131MP0002115_abnormal_skeleton_extremities0.78389502
132MP0001661_extended_life_span0.77958651
133MP0004197_abnormal_fetal_growth/weight/0.76605579
134MP0002909_abnormal_adrenal_gland0.76337649
135MP0003385_abnormal_body_wall0.76285209
136MP0002086_abnormal_extraembryonic_tissu0.75075716
137MP0003935_abnormal_craniofacial_develop0.74919428
138MP0000678_abnormal_parathyroid_gland0.74866003
139MP0005220_abnormal_exocrine_pancreas0.74836323
140MP0005670_abnormal_white_adipose0.74373324
141MP0005408_hypopigmentation0.73506118
142MP0003638_abnormal_response/metabolism_0.73430097
143MP0000566_synostosis0.73318949
144MP0005390_skeleton_phenotype0.71737070
145MP0000858_altered_metastatic_potential0.71586874
146MP0010771_integument_phenotype0.71455241
147MP0005671_abnormal_response_to0.70544627
148MP0005076_abnormal_cell_differentiation0.70225934
149MP0000534_abnormal_ureter_morphology0.70159764
150MP0003950_abnormal_plasma_membrane0.70132798
151MP0003936_abnormal_reproductive_system0.70126933
152MP0002837_dystrophic_cardiac_calcinosis0.69827037
153MP0003943_abnormal_hepatobiliary_system0.69626544
154MP0004185_abnormal_adipocyte_glucose0.67827897
155MP0009764_decreased_sensitivity_to0.64421680
156MP0003091_abnormal_cell_migration0.62935611
157MP0002116_abnormal_craniofacial_bone0.62825900
158MP0002249_abnormal_larynx_morphology0.62717741
159MP0005193_abnormal_anterior_eye0.62665730
160MP0001790_abnormal_immune_system0.62199050
161MP0005387_immune_system_phenotype0.62199050
162MP0002166_altered_tumor_susceptibility0.61452793
163MP0003937_abnormal_limbs/digits/tail_de0.59805138
164MP0002877_abnormal_melanocyte_morpholog0.58550465
165MP0001177_atelectasis0.58144642
166MP0002092_abnormal_eye_morphology0.56726183
167MP0000049_abnormal_middle_ear0.55912836
168MP0009931_abnormal_skin_appearance0.54848669
169MP0002109_abnormal_limb_morphology0.54520942
170MP0003941_abnormal_skin_development0.53964597
171MP0000343_altered_response_to0.53483743
172MP0004858_abnormal_nervous_system0.53239070
173MP0004130_abnormal_muscle_cell0.52504734
174MP0001191_abnormal_skin_condition0.49925366
175MP0003795_abnormal_bone_structure0.49439149

Predicted human phenotypes

RankGene SetZ-score
1Alacrima (HP:0000522)9.83944561
2Nasolacrimal duct obstruction (HP:0000579)8.12681326
3Decreased lacrimation (HP:0000633)7.80836977
4Microretrognathia (HP:0000308)7.15273505
5Abnormality of the lacrimal duct (HP:0011481)7.13041778
6Mixed hearing impairment (HP:0000410)7.09122685
7Right ventricular cardiomyopathy (HP:0011663)6.53912388
8Abnormality of the nasolacrimal system (HP:0000614)6.19635898
9Periauricular skin pits (HP:0100277)6.12204885
10Preauricular pit (HP:0004467)6.12204885
11Onycholysis (HP:0001806)5.82659337
12Milia (HP:0001056)5.61976155
13Atrophic scars (HP:0001075)5.30335933
14Scapular winging (HP:0003691)5.26077838
15Abnormality of the antihelix (HP:0009738)4.89345765
16Fragile nails (HP:0001808)4.47326087
17Intellectual disability, moderate (HP:0002342)4.35440189
18Selective tooth agenesis (HP:0001592)4.25416531
19Skin pits (HP:0100276)4.15376680
20Chronic otitis media (HP:0000389)4.00093593
21Plantar hyperkeratosis (HP:0007556)3.74021320
22Pili torti (HP:0003777)3.51271370
23Abnormality of methionine metabolism (HP:0010901)3.30782687
24Atresia of the external auditory canal (HP:0000413)3.30728627
25Ulnar bowing (HP:0003031)3.20808117
26Chromsome breakage (HP:0040012)3.08495363
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.00241246
28Abnormality of the labia minora (HP:0012880)2.99171890
29Micronodular cirrhosis (HP:0001413)2.97393052
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96082802
31Lip pit (HP:0100267)2.94780441
32Abnormality of the shoulder girdle musculature (HP:0001435)2.93199572
33Abnormality of homocysteine metabolism (HP:0010919)2.84629252
34Homocystinuria (HP:0002156)2.84629252
35Sprengel anomaly (HP:0000912)2.83434998
36Birth length less than 3rd percentile (HP:0003561)2.78687170
37Esophageal atresia (HP:0002032)2.75030800
38Nail dystrophy (HP:0008404)2.73749278
39Hypotrichosis (HP:0001006)2.72409001
40Woolly hair (HP:0002224)2.71452555
41Type I transferrin isoform profile (HP:0003642)2.70096892
42Shallow orbits (HP:0000586)2.69762086
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.65230368
44Esophageal varix (HP:0002040)2.64506476
45Abnormality of the preputium (HP:0100587)2.59575312
46Natal tooth (HP:0000695)2.57750975
47Ventricular fibrillation (HP:0001663)2.50470327
48Pancreatic islet-cell hyperplasia (HP:0004510)2.44177343
49Blue sclerae (HP:0000592)2.43615903
50Premature skin wrinkling (HP:0100678)2.43547370
51Acute encephalopathy (HP:0006846)2.39653314
52Megaloblastic anemia (HP:0001889)2.38933636
53Hypokinesia (HP:0002375)2.36772561
54Bowing of the arm (HP:0006488)2.35742863
55Bowed forearm bones (HP:0003956)2.35742863
56Hyperactive renin-angiotensin system (HP:0000841)2.33967049
57Abnormal lung lobation (HP:0002101)2.33721684
58Hypoplastic labia majora (HP:0000059)2.33278663
59Ureteral stenosis (HP:0000071)2.33059270
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.31796668
61Meckel diverticulum (HP:0002245)2.30973385
62Abnormality of chromosome stability (HP:0003220)2.27392314
63Acute necrotizing encephalopathy (HP:0006965)2.26975178
64Abnormality of the gastric mucosa (HP:0004295)2.24766449
65Ankle contracture (HP:0006466)2.24550783
66Hypoplasia of dental enamel (HP:0006297)2.23581237
67Abnormal hair laboratory examination (HP:0003328)2.22463737
68Colon cancer (HP:0003003)2.20283291
69Advanced eruption of teeth (HP:0006288)2.19218849
70Progressive macrocephaly (HP:0004481)2.18803295
71Abnormality of the ileum (HP:0001549)2.18686040
72Methylmalonic acidemia (HP:0002912)2.17464111
73Increased CSF lactate (HP:0002490)2.17434480
74Posterior subcapsular cataract (HP:0007787)2.16847677
75Breast carcinoma (HP:0003002)2.15974749
76Reduced antithrombin III activity (HP:0001976)2.14688349
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14295266
78Abnormal protein N-linked glycosylation (HP:0012347)2.14295266
79Abnormal protein glycosylation (HP:0012346)2.14295266
80Abnormal glycosylation (HP:0012345)2.14295266
81Hypoglycemic coma (HP:0001325)2.14081701
82Stridor (HP:0010307)2.11699778
83Abnormality of the vitamin B12 metabolism (HP:0004341)2.11637492
84Nasal polyposis (HP:0100582)2.09825683
85Hypoglycemic seizures (HP:0002173)2.08324598
86Ureteral obstruction (HP:0006000)2.07721805
87Proximal tubulopathy (HP:0000114)2.06234563
88Duodenal stenosis (HP:0100867)2.06031186
89Small intestinal stenosis (HP:0012848)2.06031186
90Abnormality of the pons (HP:0007361)2.05969681
91Abnormality of vitamin B metabolism (HP:0004340)2.05673952
92Abnormal mitochondria in muscle tissue (HP:0008316)2.03265622
93Ependymoma (HP:0002888)2.03192464
94Fragile skin (HP:0001030)2.01030228
95Hyperinsulinemic hypoglycemia (HP:0000825)1.99730478
96Methylmalonic aciduria (HP:0012120)1.98845950
97Abnormality of the labia majora (HP:0012881)1.98608872
98Curly hair (HP:0002212)1.97694136
99Duplicated collecting system (HP:0000081)1.97504594
100Hypoplasia of the pons (HP:0012110)1.95929942
101Pterygium (HP:0001059)1.93739133
102Ventricular arrhythmia (HP:0004308)1.92148626
103Hyperglycinuria (HP:0003108)1.91530911
104Periodontitis (HP:0000704)1.91167791
105Biliary tract neoplasm (HP:0100574)1.91040216
106Increased serum lactate (HP:0002151)1.90456070
107Tapered finger (HP:0001182)1.90113403
108Multiple enchondromatosis (HP:0005701)1.89792928
109Ventricular tachycardia (HP:0004756)1.89109914
110Increased hepatocellular lipid droplets (HP:0006565)1.88531351
111Broad metatarsal (HP:0001783)1.87930629
112Horseshoe kidney (HP:0000085)1.86509141
113Angiofibromas (HP:0010615)1.86480853
114Adenoma sebaceum (HP:0009720)1.86480853
115Volvulus (HP:0002580)1.85964418
116Sparse scalp hair (HP:0002209)1.85542579
117Abnormality of serum amino acid levels (HP:0003112)1.85323232
118Sloping forehead (HP:0000340)1.82994446
119Chronic mucocutaneous candidiasis (HP:0002728)1.81658357
120Recurrent cutaneous fungal infections (HP:0011370)1.81658357
121Abnormality of cochlea (HP:0000375)1.80785504
122Aplasia cutis congenita (HP:0001057)1.80658966
123Abnormality of macular pigmentation (HP:0008002)1.80323416
124Conjunctival hamartoma (HP:0100780)1.79940860
125Cerebral edema (HP:0002181)1.79764697
126Abnormality of endocrine pancreas physiology (HP:0012093)1.79329065
127Abnormality of the pancreatic islet cells (HP:0006476)1.79329065
128Abnormality of the renal collecting system (HP:0004742)1.78911053
129Stenosis of the external auditory canal (HP:0000402)1.78640641
130Mitochondrial inheritance (HP:0001427)1.77891509
131Ovarian neoplasm (HP:0100615)1.77674823
132Abnormality of the nasal mucosa (HP:0000433)1.76549415
133Lipid accumulation in hepatocytes (HP:0006561)1.76366949
134Median cleft lip (HP:0000161)1.76222657
135Pyloric stenosis (HP:0002021)1.76094096
136Poikiloderma (HP:0001029)1.75646009
137Glioma (HP:0009733)1.75360841
138Abnormality of serine family amino acid metabolism (HP:0010894)1.74581100
139Abnormality of glycine metabolism (HP:0010895)1.74581100
140Abnormality of oral frenula (HP:0000190)1.74279506
141Chronic bronchitis (HP:0004469)1.74146463
142Neoplasm of the adrenal gland (HP:0100631)1.73776650
143Cutaneous melanoma (HP:0012056)1.73426337
144Abnormality of the duodenum (HP:0002246)1.72032068
145Abnormality of the astrocytes (HP:0100707)1.70763553
146Astrocytoma (HP:0009592)1.70763553
147Abnormality of glycolysis (HP:0004366)1.70696361
148Absent radius (HP:0003974)1.70448146
149Neonatal death (HP:0003811)1.68893519
150Osteolytic defects of the hand bones (HP:0009699)1.68777479
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.68777479
152Symptomatic seizures (HP:0011145)1.68716774
153Ectopic kidney (HP:0000086)1.68211984
154Overriding aorta (HP:0002623)1.68145120
155Squamous cell carcinoma (HP:0002860)1.67143119
156Sudden cardiac death (HP:0001645)1.66908646
157Cerebral aneurysm (HP:0004944)1.66778603
158Hypoplastic female external genitalia (HP:0012815)1.65751645
159Lethargy (HP:0001254)1.64162321
160Pancreatic cysts (HP:0001737)1.64003879
161Absent thumb (HP:0009777)1.63970369
162Hypoplasia of the uterus (HP:0000013)1.63649667
163Nephroblastoma (Wilms tumor) (HP:0002667)1.63485540
164Carious teeth (HP:0000670)1.62906324
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.62088347
166Abnormal blistering of the skin (HP:0008066)1.61284369
167Growth hormone excess (HP:0000845)1.60554277
168Palmoplantar hyperkeratosis (HP:0000972)1.58085989
169Dental malocclusion (HP:0000689)1.57430712
170Ankyloglossia (HP:0010296)1.57281367
171Long toe (HP:0010511)1.55675722
172Unilateral renal agenesis (HP:0000122)1.54485564
173Oligodontia (HP:0000677)1.51681060
174Full cheeks (HP:0000293)1.51465032
175Hallux valgus (HP:0001822)1.50683670
176Sparse eyelashes (HP:0000653)1.50253266
177Hyperacusis (HP:0010780)1.50078918
178Viral hepatitis (HP:0006562)1.49485568
179Disproportionate tall stature (HP:0001519)1.49422998
180Colitis (HP:0002583)1.47089511
181Facial asymmetry (HP:0000324)1.46342248
182Hypodontia (HP:0000668)1.45925260
183Insomnia (HP:0100785)1.45623180
184Loss of speech (HP:0002371)1.43630161
185Palpitations (HP:0001962)1.42975547
186Palmar hyperkeratosis (HP:0010765)1.42235343
187Slender long bone (HP:0003100)1.41306061
188Broad distal phalanx of finger (HP:0009836)1.40347619
189Pointed chin (HP:0000307)1.36041348
190Deviation of the hallux (HP:0010051)1.34832864
191Asymmetry of the thorax (HP:0001555)1.34229992
192Morphological abnormality of the middle ear (HP:0008609)1.34158719
193Buphthalmos (HP:0000557)1.33579775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.90638039
2TSSK63.69564986
3BUB13.50501927
4FGFR43.29249135
5RPS6KB23.27149733
6BRSK23.25172569
7TRIM282.86955468
8TTN2.82255623
9EPHB12.79969681
10VRK22.70552469
11FRK2.65728308
12TYK22.57730350
13PBK2.53005863
14EIF2AK32.46499091
15EEF2K2.43915247
16SRPK12.43198693
17ERN12.38588532
18LATS12.37216383
19EIF2AK12.26004000
20FGFR22.20947503
21CDC72.19778865
22MST1R2.13648685
23TNIK2.09301929
24SIK12.06694457
25RIPK11.94789122
26WEE11.93220288
27PKN21.91471340
28NME11.89724756
29SIK31.84289053
30LMTK21.81728339
31NUAK11.76356476
32FGFR31.73358459
33PTK61.72413386
34EPHA21.69995766
35MKNK21.66615694
36STK391.65253924
37FER1.64337354
38STK161.60949044
39JAK11.60395454
40ZAK1.58667286
41PAK21.54612738
42TGFBR11.52826554
43BRSK11.51368465
44MST41.50128881
45TAF11.48867100
46TRIB31.48596651
47JAK31.47791771
48NLK1.47353101
49VRK11.43757306
50INSRR1.43694562
51NEK11.42819229
52MAP2K21.38392591
53PLK41.37695463
54PINK11.37522876
55PDK21.34725878
56EPHA31.34631893
57DMPK1.34600156
58ACVR1B1.31570102
59MKNK11.31499008
60ERBB21.31252506
61CSNK1G11.29167945
62MAP3K101.28959583
63LRRK21.28722693
64KIT1.20047055
65BMPR1B1.19930923
66JAK21.19620841
67OXSR11.19298550
68BCR1.15657372
69CAMK2G1.13861438
70PLK11.13131468
71BTK1.12026158
72PTK21.11866481
73PASK1.11133964
74IKBKE1.09775410
75MAP3K21.08560598
76MAP3K131.05993233
77PRKCI1.05809581
78MET1.05419288
79MAP3K91.04781400
80RET1.04770046
81CSNK1G31.03566840
82NME21.02163554
83MAPKAPK20.98184058
84STK240.94104741
85LATS20.94038585
86RIPK40.94003505
87SCYL20.93358754
88CDC42BPA0.92534041
89CAMK2B0.90743684
90KSR20.90519232
91MAPKAPK30.88934467
92MAP3K30.85118384
93ATR0.84796918
94EPHB20.82351138
95MAP4K20.81627236
96EIF2AK20.80680905
97CSNK1A1L0.80413784
98CHEK20.80290099
99MUSK0.79708170
100ERBB30.77888598
101CSNK1G20.76770588
102WNK30.72010533
103GRK10.71494658
104DDR20.70155701
105ITK0.69757563
106ROCK20.67904209
107AURKB0.67822620
108STK38L0.67233298
109MAPKAPK50.65172508
110NEK60.64917964
111ATM0.64722831
112GSK3A0.62712947
113MAPK110.62419375
114BCKDK0.61434604
115MAP2K10.60332128
116TGFBR20.59885844
117CHEK10.59349321
118RPS6KA40.58288686
119RPS6KA20.57809444
120CAMK2D0.57588516
121ALK0.57042950
122PAK40.56953350
123MAP3K120.56274954
124MARK30.54605997
125STK30.54444676
126BMPR20.54197327
127STK100.52333230
128PLK30.51885298
129CAMK10.51680619
130PDGFRA0.50750964
131ARAF0.48993826
132CDK70.48159322
133STK40.46197828
134HIPK20.45921003
135NEK20.45745472
136SMG10.45695033
137MTOR0.45100591
138MAP3K10.44913149
139CCNB10.43711665
140PRKD10.43587010
141CSNK1A10.43127712
142DAPK10.41627827
143MAP3K80.41443677
144WNK40.40977102
145CLK10.39838368
146CSNK2A10.37837013
147CSNK2A20.37751763
148FGFR10.37683535
149SRC0.36512141
150PDGFRB0.36372659
151PIK3CA0.35475245
152CDK10.34944684
153CSNK1E0.34879354
154TTK0.34723104
155CSK0.34423992
156CDK60.33807282
157PAK30.33491999
158NTRK10.33205111
159FES0.32760453
160PTK2B0.32725778
161TBK10.32094809
162TRPM70.31991911
163PRKG20.31387059
164DYRK30.31092846
165LCK0.30050891
166PRKCH0.29786879
167TYRO30.29679769
168RPS6KC10.29526790
169RPS6KL10.29526790
170MAP3K70.29198097
171FYN0.28575906
172RPS6KA10.28229717
173MAPK30.27909576
174SIK20.25674592
175MAPK40.23508760
176RPS6KA60.22089046
177TESK10.20747563

Predicted pathways (KEGG)

RankGene SetZ-score
1Antigen processing and presentation_Homo sapiens_hsa046124.39553796
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.52876919
3Proteasome_Homo sapiens_hsa030503.36188673
4DNA replication_Homo sapiens_hsa030302.93530023
5Mismatch repair_Homo sapiens_hsa034302.92223786
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91906175
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76270976
8Non-homologous end-joining_Homo sapiens_hsa034502.66250140
9Homologous recombination_Homo sapiens_hsa034402.50059638
10Protein export_Homo sapiens_hsa030602.49806912
11One carbon pool by folate_Homo sapiens_hsa006702.38693406
12RNA polymerase_Homo sapiens_hsa030202.29561761
13ECM-receptor interaction_Homo sapiens_hsa045122.24204264
14Toxoplasmosis_Homo sapiens_hsa051452.21886103
15Notch signaling pathway_Homo sapiens_hsa043302.18477497
16RNA transport_Homo sapiens_hsa030132.13467631
17Caffeine metabolism_Homo sapiens_hsa002322.05345605
18Cyanoamino acid metabolism_Homo sapiens_hsa004602.03220757
19Basal transcription factors_Homo sapiens_hsa030221.99573550
20Fanconi anemia pathway_Homo sapiens_hsa034601.97722117
21Base excision repair_Homo sapiens_hsa034101.94488683
22Estrogen signaling pathway_Homo sapiens_hsa049151.85544949
23Small cell lung cancer_Homo sapiens_hsa052221.83515396
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.76350352
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73532336
26Nucleotide excision repair_Homo sapiens_hsa034201.72133141
27Selenocompound metabolism_Homo sapiens_hsa004501.69645016
28Amoebiasis_Homo sapiens_hsa051461.68848312
29Propanoate metabolism_Homo sapiens_hsa006401.68719526
30Nitrogen metabolism_Homo sapiens_hsa009101.68494849
31RNA degradation_Homo sapiens_hsa030181.68422296
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67356930
33Fatty acid elongation_Homo sapiens_hsa000621.65614372
34Focal adhesion_Homo sapiens_hsa045101.63690218
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.59212957
36Hippo signaling pathway_Homo sapiens_hsa043901.57686724
37Osteoclast differentiation_Homo sapiens_hsa043801.55761563
38Spliceosome_Homo sapiens_hsa030401.54136972
39Insulin resistance_Homo sapiens_hsa049311.52710059
40Proteoglycans in cancer_Homo sapiens_hsa052051.50502206
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50007801
42Pyrimidine metabolism_Homo sapiens_hsa002401.46988921
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44388856
44Cell cycle_Homo sapiens_hsa041101.43521676
45Oxidative phosphorylation_Homo sapiens_hsa001901.39297377
46Vitamin B6 metabolism_Homo sapiens_hsa007501.38713194
47Folate biosynthesis_Homo sapiens_hsa007901.37172483
48Leishmaniasis_Homo sapiens_hsa051401.36003097
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32037982
50TNF signaling pathway_Homo sapiens_hsa046681.30128885
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29003670
52Ribosome_Homo sapiens_hsa030101.27966822
53Influenza A_Homo sapiens_hsa051641.25991657
54Parkinsons disease_Homo sapiens_hsa050121.23568856
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21193506
56Glutathione metabolism_Homo sapiens_hsa004801.20997541
57Pyruvate metabolism_Homo sapiens_hsa006201.19119427
58Prion diseases_Homo sapiens_hsa050201.17926772
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16905744
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15611531
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.13902150
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10728157
63Pancreatic cancer_Homo sapiens_hsa052121.10629983
64Biosynthesis of amino acids_Homo sapiens_hsa012301.10233232
65Chemokine signaling pathway_Homo sapiens_hsa040621.10043586
66Purine metabolism_Homo sapiens_hsa002301.07434718
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06620012
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06153416
69Legionellosis_Homo sapiens_hsa051341.05955149
70Cocaine addiction_Homo sapiens_hsa050301.05160086
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05110284
72mRNA surveillance pathway_Homo sapiens_hsa030151.03825924
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01948244
74Apoptosis_Homo sapiens_hsa042100.99214350
75Bladder cancer_Homo sapiens_hsa052190.98496259
76Type II diabetes mellitus_Homo sapiens_hsa049300.97395176
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97387296
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97263395
79Fatty acid degradation_Homo sapiens_hsa000710.96672884
80Renal cell carcinoma_Homo sapiens_hsa052110.95700066
81Adherens junction_Homo sapiens_hsa045200.95589944
82Prolactin signaling pathway_Homo sapiens_hsa049170.94906089
83Steroid biosynthesis_Homo sapiens_hsa001000.94630092
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94498926
85Butanoate metabolism_Homo sapiens_hsa006500.94353177
86Colorectal cancer_Homo sapiens_hsa052100.92728177
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.92633066
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.92589855
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92267645
90Huntingtons disease_Homo sapiens_hsa050160.90878384
91Vitamin digestion and absorption_Homo sapiens_hsa049770.90805235
92Rheumatoid arthritis_Homo sapiens_hsa053230.90719569
93Sulfur metabolism_Homo sapiens_hsa009200.90371926
94B cell receptor signaling pathway_Homo sapiens_hsa046620.90314062
95Carbon metabolism_Homo sapiens_hsa012000.90222553
96Pathways in cancer_Homo sapiens_hsa052000.87865648
97Hepatitis B_Homo sapiens_hsa051610.87436136
98Oocyte meiosis_Homo sapiens_hsa041140.85997852
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85098748
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85067161
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.84949456
102Chronic myeloid leukemia_Homo sapiens_hsa052200.84034350
103Fat digestion and absorption_Homo sapiens_hsa049750.82820869
104Endometrial cancer_Homo sapiens_hsa052130.80957659
105Arginine and proline metabolism_Homo sapiens_hsa003300.80510681
106Metabolic pathways_Homo sapiens_hsa011000.80250731
107Retinol metabolism_Homo sapiens_hsa008300.77090665
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76615971
109Hepatitis C_Homo sapiens_hsa051600.76527095
110Herpes simplex infection_Homo sapiens_hsa051680.76224423
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76173786
112Axon guidance_Homo sapiens_hsa043600.75988424
113p53 signaling pathway_Homo sapiens_hsa041150.75523526
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74172595
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73769176
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73563279
117Measles_Homo sapiens_hsa051620.73472239
118beta-Alanine metabolism_Homo sapiens_hsa004100.73240759
119Phototransduction_Homo sapiens_hsa047440.72616508
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.70114699
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69100827
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69075116
123VEGF signaling pathway_Homo sapiens_hsa043700.69063096
124Thyroid cancer_Homo sapiens_hsa052160.68687423
125Tight junction_Homo sapiens_hsa045300.66742661
126Peroxisome_Homo sapiens_hsa041460.65997617
127Shigellosis_Homo sapiens_hsa051310.65016192
128Sphingolipid metabolism_Homo sapiens_hsa006000.64454979
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62992936
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.62844820
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62359320
132PPAR signaling pathway_Homo sapiens_hsa033200.62099739
133African trypanosomiasis_Homo sapiens_hsa051430.61826189
134Rap1 signaling pathway_Homo sapiens_hsa040150.61529639
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61210313
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60632410
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60499630
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60117449
139Pentose phosphate pathway_Homo sapiens_hsa000300.59691089
140Sulfur relay system_Homo sapiens_hsa041220.59557257
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59436926
142Pertussis_Homo sapiens_hsa051330.59337010
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58341622
144Dorso-ventral axis formation_Homo sapiens_hsa043200.58205625
145Amphetamine addiction_Homo sapiens_hsa050310.57870217
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57135454
147Salmonella infection_Homo sapiens_hsa051320.56952243
148Basal cell carcinoma_Homo sapiens_hsa052170.56927212
149Non-small cell lung cancer_Homo sapiens_hsa052230.56653770
150Insulin signaling pathway_Homo sapiens_hsa049100.56575845
151HTLV-I infection_Homo sapiens_hsa051660.56092499
152Gastric acid secretion_Homo sapiens_hsa049710.56064126
153Fatty acid metabolism_Homo sapiens_hsa012120.55702059
154Chemical carcinogenesis_Homo sapiens_hsa052040.54145320
155Primary immunodeficiency_Homo sapiens_hsa053400.53967336
156Lysosome_Homo sapiens_hsa041420.53874632
157Alzheimers disease_Homo sapiens_hsa050100.53727575
158GnRH signaling pathway_Homo sapiens_hsa049120.53341160
159Fructose and mannose metabolism_Homo sapiens_hsa000510.53188612
160Tuberculosis_Homo sapiens_hsa051520.51720290
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.51151454
162Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50897190
163Linoleic acid metabolism_Homo sapiens_hsa005910.49990981
164N-Glycan biosynthesis_Homo sapiens_hsa005100.49755524
165Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49494065
166Ether lipid metabolism_Homo sapiens_hsa005650.49228724
167NF-kappa B signaling pathway_Homo sapiens_hsa040640.48922601
168mTOR signaling pathway_Homo sapiens_hsa041500.48197568
169Viral myocarditis_Homo sapiens_hsa054160.48151198
170ErbB signaling pathway_Homo sapiens_hsa040120.47605914
171Lysine degradation_Homo sapiens_hsa003100.46914715
172Acute myeloid leukemia_Homo sapiens_hsa052210.46766797
173Prostate cancer_Homo sapiens_hsa052150.46648217
174Galactose metabolism_Homo sapiens_hsa000520.46609629
175Dilated cardiomyopathy_Homo sapiens_hsa054140.46338194
176alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45814041
177Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45759027
178MAPK signaling pathway_Homo sapiens_hsa040100.45271835
179Tryptophan metabolism_Homo sapiens_hsa003800.45002678
180Viral carcinogenesis_Homo sapiens_hsa052030.44296507
181Melanogenesis_Homo sapiens_hsa049160.43783688
182Arginine biosynthesis_Homo sapiens_hsa002200.43258424
183Steroid hormone biosynthesis_Homo sapiens_hsa001400.43199870
184Starch and sucrose metabolism_Homo sapiens_hsa005000.42893842
185Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42338760
186Tyrosine metabolism_Homo sapiens_hsa003500.38533690
187Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37959469
188Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33964525
189Pancreatic secretion_Homo sapiens_hsa049720.33204757

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