PRSS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)7.92735138
2intestinal absorption (GO:0050892)7.66873104
3cholesterol catabolic process (GO:0006707)7.58763501
4sterol catabolic process (GO:0016127)7.58763501
5peptidyl-proline hydroxylation (GO:0019511)7.10259569
6cobalamin metabolic process (GO:0009235)7.07551991
7daunorubicin metabolic process (GO:0044597)6.82390110
8polyketide metabolic process (GO:0030638)6.82390110
9doxorubicin metabolic process (GO:0044598)6.82390110
10tetrapyrrole metabolic process (GO:0033013)6.72822145
11negative regulation of digestive system process (GO:0060457)6.55991299
12regulation of phospholipase A2 activity (GO:0032429)6.54921619
13cysteine metabolic process (GO:0006534)6.48741550
14phosphatidylinositol acyl-chain remodeling (GO:0036149)6.43555286
15glycolipid catabolic process (GO:0019377)6.38625100
16COPI coating of Golgi vesicle (GO:0048205)6.26873956
17Golgi transport vesicle coating (GO:0048200)6.26873956
18phosphatidylserine acyl-chain remodeling (GO:0036150)6.25290375
19phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.15177225
20aminoglycoside antibiotic metabolic process (GO:0030647)6.12788642
21membrane lipid catabolic process (GO:0046466)6.10529856
22proline biosynthetic process (GO:0006561)5.90303068
23regulation of keratinocyte differentiation (GO:0045616)5.57954327
24protein maturation by protein folding (GO:0022417)5.48421343
25ceramide catabolic process (GO:0046514)5.46093333
26branched-chain amino acid catabolic process (GO:0009083)5.40439795
27protein hydroxylation (GO:0018126)5.36447795
28valine metabolic process (GO:0006573)5.34544947
29icosanoid transport (GO:0071715)5.32206401
30fatty acid derivative transport (GO:1901571)5.32206401
31activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.17481343
32regulation of keratinocyte proliferation (GO:0010837)5.14040875
33water-soluble vitamin metabolic process (GO:0006767)4.97506852
34positive regulation of nuclease activity (GO:0032075)4.94981142
35zinc ion transport (GO:0006829)4.91432921
36innate immune response in mucosa (GO:0002227)4.90852837
37cellular modified amino acid catabolic process (GO:0042219)4.87915366
38branched-chain amino acid metabolic process (GO:0009081)4.77519869
39response to endoplasmic reticulum stress (GO:0034976)4.71780299
40endoplasmic reticulum unfolded protein response (GO:0030968)4.68548944
41digestive system process (GO:0022600)4.62464851
42regulation of acrosome reaction (GO:0060046)4.60351508
43acute-phase response (GO:0006953)4.57676193
44signal peptide processing (GO:0006465)4.55742226
45cellular response to unfolded protein (GO:0034620)4.55559986
46serine family amino acid biosynthetic process (GO:0009070)4.54263956
47positive regulation of heat generation (GO:0031652)4.54032397
48regulation of nuclease activity (GO:0032069)4.50257099
494-hydroxyproline metabolic process (GO:0019471)4.48283765
50phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.42616993
51GDP-mannose metabolic process (GO:0019673)4.41151803
52regulation of fever generation (GO:0031620)4.39936520
53cellular response to topologically incorrect protein (GO:0035967)4.35374929
54intestinal epithelial cell development (GO:0060576)4.35139122
55ER-nucleus signaling pathway (GO:0006984)4.31724706
56calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.28841013
57homocysteine metabolic process (GO:0050667)4.28694979
58mitochondrial calcium ion transport (GO:0006851)4.27348196
59maintenance of protein localization in organelle (GO:0072595)4.27023516
60phosphatidylserine metabolic process (GO:0006658)4.24371166
61aspartate family amino acid catabolic process (GO:0009068)4.22553876
62cellular protein catabolic process (GO:0044257)4.20430602
63leukotriene biosynthetic process (GO:0019370)4.19873293
64leukotriene metabolic process (GO:0006691)4.16690808
65negative regulation of epidermal cell differentiation (GO:0045605)4.14956396
66endocrine pancreas development (GO:0031018)4.13429787
67COPII vesicle coating (GO:0048208)4.09867894
68glutamine metabolic process (GO:0006541)4.06859529
69maintenance of gastrointestinal epithelium (GO:0030277)4.01290550
70mucosal immune response (GO:0002385)4.00328510
71ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.99374289
72proline metabolic process (GO:0006560)3.93657360
73vitamin metabolic process (GO:0006766)3.89625955
74phosphatidylcholine acyl-chain remodeling (GO:0036151)3.83626459
75creatine metabolic process (GO:0006600)3.81864564
76steroid catabolic process (GO:0006706)3.81800610
77neutrophil mediated immunity (GO:0002446)3.75967090
78response to unfolded protein (GO:0006986)3.74502515
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.73102514
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71456037
81L-phenylalanine catabolic process (GO:0006559)3.71456037
82regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.69103927
83L-serine metabolic process (GO:0006563)3.68422693
84phosphatidic acid biosynthetic process (GO:0006654)3.62560633
85phosphatidic acid metabolic process (GO:0046473)3.62560633
86response to topologically incorrect protein (GO:0035966)3.62007539
87organ or tissue specific immune response (GO:0002251)3.61974735
88regulation of metalloenzyme activity (GO:0048552)3.61564941
89protein N-linked glycosylation via asparagine (GO:0018279)3.61066519
90phospholipid catabolic process (GO:0009395)3.60779816
91peptidyl-asparagine modification (GO:0018196)3.57717481
92serine family amino acid metabolic process (GO:0009069)3.55698828
93ER overload response (GO:0006983)3.55433859
94coenzyme catabolic process (GO:0009109)3.54188702
95alditol phosphate metabolic process (GO:0052646)3.53865713
96sphingolipid catabolic process (GO:0030149)3.52206829
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.51653508
98L-phenylalanine metabolic process (GO:0006558)3.51653508
99regulation of triglyceride catabolic process (GO:0010896)3.47392374
100regulation of heat generation (GO:0031650)3.46243165
101regulation of epidermal cell differentiation (GO:0045604)3.45179895
102glycoside metabolic process (GO:0016137)3.45084789
103L-alpha-amino acid transmembrane transport (GO:1902475)3.43676711
104antibacterial humoral response (GO:0019731)3.42497315
105defense response to Gram-positive bacterium (GO:0050830)3.38130649
106cell redox homeostasis (GO:0045454)3.37692896
107progesterone metabolic process (GO:0042448)3.36276756
108protein N-linked glycosylation (GO:0006487)3.29647894
109primary alcohol catabolic process (GO:0034310)3.28783679
110glutathione derivative biosynthetic process (GO:1901687)3.27917830
111glutathione derivative metabolic process (GO:1901685)3.27917830
112retinoid metabolic process (GO:0001523)3.22328006
113acute inflammatory response (GO:0002526)3.19472122
114antimicrobial humoral response (GO:0019730)3.18163131
115negative regulation of epithelial cell differentiation (GO:0030857)3.13003613
116sulfur amino acid biosynthetic process (GO:0000097)3.12647371
117pancreas development (GO:0031016)3.12643590
118positive regulation of wound healing (GO:0090303)3.12541859
119fatty acid derivative biosynthetic process (GO:1901570)3.08736638
120icosanoid biosynthetic process (GO:0046456)3.08736638
121mitochondrion distribution (GO:0048311)3.08438609
122regulation of cholesterol homeostasis (GO:2000188)3.07299802
123negative regulation of epidermis development (GO:0045683)3.05055475
124diterpenoid metabolic process (GO:0016101)3.03132196
125cholesterol transport (GO:0030301)3.01560107
126sterol transport (GO:0015918)3.01560107
127polarized epithelial cell differentiation (GO:0030859)3.00614948
128retinoic acid receptor signaling pathway (GO:0048384)2.99714307
129alpha-amino acid biosynthetic process (GO:1901607)2.97598638
130positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.96795655
131glycine metabolic process (GO:0006544)2.96398267
132arachidonic acid secretion (GO:0050482)2.93609669
133icosanoid secretion (GO:0032309)2.93609669
134endothelial cell migration (GO:0043542)2.93428495
135cellular response to cadmium ion (GO:0071276)2.88845067
136nucleotide-sugar biosynthetic process (GO:0009226)2.88104401
137myeloid leukocyte mediated immunity (GO:0002444)2.87658370
138glycine transport (GO:0015816)2.87129609
139regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.84272357
140regulation of calcium ion import (GO:0090279)2.84133293
141biotin metabolic process (GO:0006768)2.83913973
142peptide catabolic process (GO:0043171)2.82431252
143negative regulation of hormone metabolic process (GO:0032351)2.80473246
144phosphatidylglycerol metabolic process (GO:0046471)2.78684790
145regulation of oxidative stress-induced cell death (GO:1903201)2.78296004
146phototransduction, visible light (GO:0007603)2.77801895
147sulfur amino acid catabolic process (GO:0000098)2.77777708
148retinal metabolic process (GO:0042574)2.77704256
149retina layer formation (GO:0010842)2.77517079
150peptidyl-proline modification (GO:0018208)2.77409192
151regulation of hormone metabolic process (GO:0032350)2.77085331
152response to pheromone (GO:0019236)2.76809006
153epithelial structure maintenance (GO:0010669)2.73201663
154peroxisome fission (GO:0016559)2.70448448
155cellular response to zinc ion (GO:0071294)2.67192186
156terpenoid metabolic process (GO:0006721)2.65877829
157glucuronate metabolic process (GO:0019585)2.63877259
158uronic acid metabolic process (GO:0006063)2.63877259
159macroautophagy (GO:0016236)2.57767438
160* extracellular matrix disassembly (GO:0022617)2.55716501
161renal absorption (GO:0070293)2.52947062
162cellular glucuronidation (GO:0052695)2.50366825
163water-soluble vitamin biosynthetic process (GO:0042364)2.46625325
164exocrine pancreas development (GO:0031017)17.2562648
165intestinal cholesterol absorption (GO:0030299)17.2238933
166protein retention in ER lumen (GO:0006621)12.4172293
167* digestion (GO:0007586)12.3190977
168maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.7023938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.10657740
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.22274102
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.15310627
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.52856870
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.31766354
6ERG_21242973_ChIP-ChIP_JURKAT_Human3.09764482
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.92480095
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.79746060
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.63185578
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.60072828
11GATA4_25053715_ChIP-Seq_YYC3_Human2.30675610
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.25921509
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.22661878
14GATA1_22025678_ChIP-Seq_K562_Human2.20460921
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19009841
16PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.03152924
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01838925
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01838925
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01838925
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98003457
21GATA6_25053715_ChIP-Seq_YYC3_Human1.93274585
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.90746430
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86697954
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.82968258
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81051690
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.77962795
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77510616
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77184011
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76773904
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75011583
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52439388
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51992252
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48648847
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45528979
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45289863
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41226992
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36956424
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33918954
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33472967
40HNFA_21074721_ChIP-Seq_CACO-2_Human1.32360512
41CREB1_26743006_Chip-Seq_LNCaP_Human1.31699971
42FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31692125
43PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.31676628
44JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31466924
45CHD1_26751641_Chip-Seq_LNCaP_Human1.30784058
46ETV1_20927104_ChIP-Seq_GIST48_Human1.29603451
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29293305
48PHF8_20622853_ChIP-Seq_HELA_Human1.29280415
49EGR1_19032775_ChIP-ChIP_M12_Human1.28552400
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.28241658
51GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28056137
52* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27318646
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26553397
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26104091
55P68_20966046_ChIP-Seq_HELA_Human1.25463046
56LXR_22292898_ChIP-Seq_THP-1_Human1.24525975
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.24365604
58NFYA_21822215_ChIP-Seq_K562_Human1.23989948
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22978472
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22620976
61IRF1_19129219_ChIP-ChIP_H3396_Human1.21360602
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20169624
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19740344
64RBPJ_21746931_ChIP-Seq_IB4_Human1.19100717
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18555728
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18244093
67ESET_19884257_ChIP-Seq_ESCs_Mouse1.16660111
68ERG_20517297_ChIP-Seq_VCAP_Human1.15829081
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13532346
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13388969
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12663756
72FOXH1_21741376_ChIP-Seq_ESCs_Human1.11133406
73CJUN_26792858_Chip-Seq_BT549_Human1.10736224
74SOX2_20726797_ChIP-Seq_SW620_Human1.09167790
75ATF3_27146783_Chip-Seq_COLON_Human1.07710382
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06829898
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06445150
78ERA_21632823_ChIP-Seq_H3396_Human1.06102832
79OCT4_20526341_ChIP-Seq_ESCs_Human1.04096050
80ETS1_21867929_ChIP-Seq_TH2_Mouse1.04083209
81TP63_22573176_ChIP-Seq_HFKS_Human1.04031983
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03595697
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03154185
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02253363
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02088537
86FOXA1_25552417_ChIP-Seq_VCAP_Human1.02003135
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01591253
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01368728
89CLOCK_20551151_ChIP-Seq_293T_Human1.00128983
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00066864
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99620973
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99470389
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99236635
94NFYB_21822215_ChIP-Seq_K562_Human0.98441202
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97441498
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97431381
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97379547
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96787263
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.94750168
100CTCF_27219007_Chip-Seq_Bcells_Human0.93806232
101BCOR_27268052_Chip-Seq_Bcells_Human0.93413443
102ZNF274_21170338_ChIP-Seq_K562_Hela0.93263134
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92492870
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92054319
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91702566
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91192907
107P53_21459846_ChIP-Seq_SAOS-2_Human0.91128641
108CEBPB_22108803_ChIP-Seq_LS180_Human0.90951279
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90612283
110KLF4_19829295_ChIP-Seq_ESCs_Human0.89522901
111CTCF_20526341_ChIP-Seq_ESCs_Human0.89309325
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89265895
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89199421
114P300_27268052_Chip-Seq_Bcells_Human0.89170441
115* TAF2_19829295_ChIP-Seq_ESCs_Human0.88799057
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.88493644
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.88481203
118SA1_27219007_Chip-Seq_Bcells_Human0.87924802
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.87759399
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87213270
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86907978
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86907978
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86209302
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86043393
125ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85606060
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85239560
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84936151
128AR_20517297_ChIP-Seq_VCAP_Human0.82627361
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81007310
130RACK7_27058665_Chip-Seq_MCF-7_Human0.80483775
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79707845
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.79621532
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.79297440
134CBP_21632823_ChIP-Seq_H3396_Human0.79284052
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79024374
136GATA3_24758297_ChIP-Seq_MCF-7_Human0.78828983
137HTT_18923047_ChIP-ChIP_STHdh_Human0.78602763
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78037719
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77866382
140HNF4A_19822575_ChIP-Seq_HepG2_Human0.77320471
141SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.76739971
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76381105
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75825543
144CDX2_22108803_ChIP-Seq_LS180_Human0.75363004
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75129407
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74091494
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.74091494
148SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73816966
149ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72764491
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.71747290
151LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.70082581
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.69587257
153GATA3_21867929_ChIP-Seq_CD8_Mouse0.69556605
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.68751573
155SOX2_21211035_ChIP-Seq_LN229_Human0.66547947
156TBL1_22424771_ChIP-Seq_293T_Human0.66405469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption9.24541595
2MP0005083_abnormal_biliary_tract9.10606807
3MP0005220_abnormal_exocrine_pancreas6.89284498
4MP0005365_abnormal_bile_salt6.53093635
5MP0003868_abnormal_feces_composition4.89404461
6MP0005084_abnormal_gallbladder_morpholo4.56921761
7MP0005085_abnormal_gallbladder_physiolo3.31342266
8MP0002693_abnormal_pancreas_physiology3.19835539
9MP0003959_abnormal_lean_body2.70013439
10MP0001664_abnormal_digestion2.51712661
11MP0001944_abnormal_pancreas_morphology2.15037940
12MP0002139_abnormal_hepatobiliary_system1.97497919
13MP0003705_abnormal_hypodermis_morpholog1.75569832
14MP0004264_abnormal_extraembryonic_tissu1.74570338
15MP0005448_abnormal_energy_balance1.70518352
16MP0003638_abnormal_response/metabolism_1.66491881
17MP0004233_abnormal_muscle_weight1.63284800
18MP0010234_abnormal_vibrissa_follicle1.53752214
19MP0002277_abnormal_respiratory_mucosa1.53164056
20MP0003011_delayed_dark_adaptation1.52373526
21MP0002138_abnormal_hepatobiliary_system1.51003380
22MP0002118_abnormal_lipid_homeostasis1.41445678
23MP0005451_abnormal_body_composition1.39186303
24MP0005332_abnormal_amino_acid1.34734765
25MP0009840_abnormal_foam_cell1.34149593
26MP0005165_increased_susceptibility_to1.33210027
27MP0002078_abnormal_glucose_homeostasis1.26223195
28MP0003252_abnormal_bile_duct1.22196538
29MP0000003_abnormal_adipose_tissue1.04641738
30MP0005408_hypopigmentation1.00019187
31MP0009643_abnormal_urine_homeostasis0.98591380
32MP0002928_abnormal_bile_duct0.98215136
33MP0000470_abnormal_stomach_morphology0.97520370
34MP0005535_abnormal_body_temperature0.97067084
35MP0001873_stomach_inflammation0.93812454
36MP0002132_abnormal_respiratory_system0.89948621
37MP0003953_abnormal_hormone_level0.87733311
38MP0004019_abnormal_vitamin_homeostasis0.87357471
39MP0005058_abnormal_lysosome_morphology0.86676995
40MP0003943_abnormal_hepatobiliary_system0.83360088
41MP0003283_abnormal_digestive_organ0.82121252
42MP0000490_abnormal_crypts_of0.77663275
43MP0006054_spinal_hemorrhage0.77595635
44MP0003806_abnormal_nucleotide_metabolis0.74761582
45MP0005452_abnormal_adipose_tissue0.69465807
46MP0008004_abnormal_stomach_pH0.69369379
47MP0008438_abnormal_cutaneous_collagen0.68547965
48MP0009384_cardiac_valve_regurgitation0.68082243
49MP0000538_abnormal_urinary_bladder0.67405207
50MP0003186_abnormal_redox_activity0.67014976
51MP0001764_abnormal_homeostasis0.66434570
52MP0000613_abnormal_salivary_gland0.65681754
53MP0000462_abnormal_digestive_system0.64999927
54MP0001663_abnormal_digestive_system0.64942807
55MP0008961_abnormal_basal_metabolism0.64525806
56MP0009765_abnormal_xenobiotic_induced0.64396906
57MP0009780_abnormal_chondrocyte_physiolo0.64390675
58MP0010329_abnormal_lipoprotein_level0.62261961
59MP0010352_gastrointestinal_tract_polyps0.60668113
60MP0006036_abnormal_mitochondrial_physio0.60348162
61MP0003183_abnormal_peptide_metabolism0.58545713
62MP0003866_abnormal_defecation0.57927082
63MP0008875_abnormal_xenobiotic_pharmacok0.57713856
64MP0005360_urolithiasis0.57663902
65MP0001501_abnormal_sleep_pattern0.57563896
66MP0003436_decreased_susceptibility_to0.57531833
67MP0003045_fibrosis0.57471224
68MP0000598_abnormal_liver_morphology0.57091731
69MP0003879_abnormal_hair_cell0.55545689
70MP0004043_abnormal_pH_regulation0.55202261
71MP0005381_digestive/alimentary_phenotyp0.53677466
72MP0008789_abnormal_olfactory_epithelium0.53544763
73MP0000609_abnormal_liver_physiology0.53153937
74MP0001731_abnormal_postnatal_growth0.52970738
75MP0002089_abnormal_postnatal_growth/wei0.52174502
76MP0002163_abnormal_gland_morphology0.49762969
77MP0002970_abnormal_white_adipose0.48703458
78MP0005375_adipose_tissue_phenotype0.48449242
79MP0001845_abnormal_inflammatory_respons0.48351974
80MP0000750_abnormal_muscle_regeneration0.46683388
81MP0005319_abnormal_enzyme/_coenzyme0.45797008
82MP0002098_abnormal_vibrissa_morphology0.45651603
83MP0003300_gastrointestinal_ulcer0.45060726
84MP0003195_calcinosis0.44868814
85MP0005166_decreased_susceptibility_to0.44273254
86MP0008469_abnormal_protein_level0.43798137
87MP0001348_abnormal_lacrimal_gland0.43491802
88MP0003329_amyloid_beta_deposits0.42976059
89MP0000678_abnormal_parathyroid_gland0.42955958
90MP0003795_abnormal_bone_structure0.42897694
91MP0000013_abnormal_adipose_tissue0.42158064
92MP0002876_abnormal_thyroid_physiology0.41973546
93MP0005334_abnormal_fat_pad0.41254983
94MP0002136_abnormal_kidney_physiology0.40966151
95MP0002877_abnormal_melanocyte_morpholog0.40761335
96MP0001542_abnormal_bone_strength0.38728301
97MP0010386_abnormal_urinary_bladder0.38167020
98MP0005394_taste/olfaction_phenotype0.37994852
99MP0005499_abnormal_olfactory_system0.37994852
100MP0010155_abnormal_intestine_physiology0.37881374
101MP0009642_abnormal_blood_homeostasis0.37022713
102MP0000955_abnormal_spinal_cord0.36110826
103MP0002896_abnormal_bone_mineralization0.35789585
104MP0000681_abnormal_thyroid_gland0.35730735
105MP0002069_abnormal_eating/drinking_beha0.35560908
106MP0005636_abnormal_mineral_homeostasis0.34144667
107MP0000367_abnormal_coat/_hair0.34001644
108MP0010678_abnormal_skin_adnexa0.33244615
109MP0002796_impaired_skin_barrier0.32716082
110MP0000371_diluted_coat_color0.32507665
111MP0003172_abnormal_lysosome_physiology0.31647672
112MP0001765_abnormal_ion_homeostasis0.31494281
113MP0009764_decreased_sensitivity_to0.30494474
114MP0003656_abnormal_erythrocyte_physiolo0.30340972
115MP0000465_gastrointestinal_hemorrhage0.29899148
116MP0002909_abnormal_adrenal_gland0.29837702
117MP0004185_abnormal_adipocyte_glucose0.27966753
118MP0000377_abnormal_hair_follicle0.27790079
119MP0008872_abnormal_physiological_respon0.27748108
120MP0001756_abnormal_urination0.27483587
121MP0003075_altered_response_to0.27407642
122MP0001533_abnormal_skeleton_physiology0.26975400
123MP0001502_abnormal_circadian_rhythm0.26327446
124MP0001485_abnormal_pinna_reflex0.26227574
125MP0002060_abnormal_skin_morphology0.25485490
126MP0003956_abnormal_body_size0.25325500
127MP0004924_abnormal_behavior0.25089145
128MP0005386_behavior/neurological_phenoty0.25089145
129MP0005187_abnormal_penis_morphology0.24942399
130MP0000477_abnormal_intestine_morphology0.24809793
131MP0000858_altered_metastatic_potential0.24394778
132MP0002168_other_aberrant_phenotype0.24270181
133MP0003950_abnormal_plasma_membrane0.24152407
134MP0005595_abnormal_vascular_smooth0.23745674
135MP0003646_muscle_fatigue0.23576430
136MP0000467_abnormal_esophagus_morphology0.22990830
137MP0008995_early_reproductive_senescence0.22943836
138MP0005670_abnormal_white_adipose0.22237861
139MP0005410_abnormal_fertilization0.21683914

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.88112013
2Fat malabsorption (HP:0002630)6.65344262
3Short chin (HP:0000331)6.30855822
4Decreased subcutaneous fat (HP:0001002)6.20951447
5Gout (HP:0001997)5.83623186
6Abnormality of subcutaneous fat tissue (HP:0001001)5.56100164
7Type I diabetes mellitus (HP:0100651)5.48015932
8Abnormality of the intrinsic pathway (HP:0010989)4.95259954
9Maternal diabetes (HP:0009800)4.95155372
10Exocrine pancreatic insufficiency (HP:0001738)4.81264658
11Abnormality of the pleura (HP:0002103)4.40082644
12Abnormality of aromatic amino acid family metabolism (HP:0004338)4.33711234
13Hypoplasia of the pons (HP:0012110)4.27069560
14Ketoacidosis (HP:0001993)4.13521097
15Hydroxyprolinuria (HP:0003080)4.10056643
16Abnormality of proline metabolism (HP:0010907)4.10056643
17Abnormality of the pons (HP:0007361)4.04371234
18Ketosis (HP:0001946)3.97798898
19Joint stiffness (HP:0001387)3.90501941
20Abnormal pancreas size (HP:0012094)3.81544936
21Hypoglycemic coma (HP:0001325)3.71686508
22Abnormality of endocrine pancreas physiology (HP:0012093)3.70757807
23Abnormality of the pancreatic islet cells (HP:0006476)3.70757807
24Pancreatitis (HP:0001733)3.63195471
25Cortical dysplasia (HP:0002539)3.57492297
26Hypoglycemic seizures (HP:0002173)3.55535332
27Premature skin wrinkling (HP:0100678)3.45677160
28Hyperinsulinemic hypoglycemia (HP:0000825)3.39422055
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.37405340
30Tubulointerstitial nephritis (HP:0001970)3.21017377
31Tetraparesis (HP:0002273)3.20738092
32Goiter (HP:0000853)3.17525793
33Abnormality of the common coagulation pathway (HP:0010990)3.06481387
34Hypoproteinemia (HP:0003075)2.96287982
35Optic nerve hypoplasia (HP:0000609)2.93338124
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92971332
37Abnormal protein N-linked glycosylation (HP:0012347)2.92971332
38Abnormal protein glycosylation (HP:0012346)2.92971332
39Abnormal glycosylation (HP:0012345)2.92971332
40Carpal bone hypoplasia (HP:0001498)2.89627526
41Anal atresia (HP:0002023)2.86402092
42Tubulointerstitial fibrosis (HP:0005576)2.85703968
43Long foot (HP:0001833)2.83448063
44Progressive muscle weakness (HP:0003323)2.82417880
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.81595176
46Prenatal maternal abnormality (HP:0002686)2.78279186
47Late onset (HP:0003584)2.77344016
48Hyperglycinemia (HP:0002154)2.76375411
49Dysostosis multiplex (HP:0000943)2.64745033
50Vascular calcification (HP:0004934)2.62383883
51Hyperuricemia (HP:0002149)2.60319475
52Increased purine levels (HP:0004368)2.60319475
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.54928070
54Symptomatic seizures (HP:0011145)2.52206248
55Pectus carinatum (HP:0000768)2.49826257
56Congenital, generalized hypertrichosis (HP:0004540)2.48873250
57Congenital glaucoma (HP:0001087)2.42368331
58Hyperglycinuria (HP:0003108)2.41185873
59Fatigue (HP:0012378)2.40980805
60Abnormal sex determination (HP:0012244)2.40960087
61Sex reversal (HP:0012245)2.40960087
62Hyperglycemia (HP:0003074)2.40732894
63Vacuolated lymphocytes (HP:0001922)2.38858731
64Abnormality of the distal phalanges of the toes (HP:0010182)2.34889003
65Abnormality of glycine metabolism (HP:0010895)2.33413165
66Abnormality of serine family amino acid metabolism (HP:0010894)2.33413165
67Ileus (HP:0002595)2.32754710
68Acute hepatic failure (HP:0006554)2.29988936
69Cardiovascular calcification (HP:0011915)2.27017035
70Large for gestational age (HP:0001520)2.26665576
71Cortical visual impairment (HP:0100704)2.25060889
72Abnormal tarsal ossification (HP:0008369)2.22929747
73Abnormality of the nasal septum (HP:0000419)2.22523900
74Hypoplasia of the odontoid process (HP:0003311)2.19188885
75Type II lissencephaly (HP:0007260)2.17215487
76Abnormality of methionine metabolism (HP:0010901)2.15374738
77Reduced antithrombin III activity (HP:0001976)2.13089231
78Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10484355
79Methylmalonic aciduria (HP:0012120)2.09622005
80Hypsarrhythmia (HP:0002521)2.08182768
81Beaking of vertebral bodies (HP:0004568)2.02157669
82Opisthotonus (HP:0002179)2.00544009
83Abnormality of homocysteine metabolism (HP:0010919)2.00130999
84Homocystinuria (HP:0002156)2.00130999
85Myocardial infarction (HP:0001658)2.00057152
86EEG with generalized epileptiform discharges (HP:0011198)1.98419437
87Conjugated hyperbilirubinemia (HP:0002908)1.94639901
88Urinary glycosaminoglycan excretion (HP:0003541)1.93993947
89Mucopolysacchariduria (HP:0008155)1.93993947
90Stenosis of the external auditory canal (HP:0000402)1.93359518
91Hyperphosphatemia (HP:0002905)1.92981582
92Abnormality of purine metabolism (HP:0004352)1.89433682
93Right ventricular cardiomyopathy (HP:0011663)1.89202404
94Limb hypertonia (HP:0002509)1.89138717
95Epileptiform EEG discharges (HP:0011182)1.88760329
96Pancreatic islet-cell hyperplasia (HP:0004510)1.88244707
97Barrel-shaped chest (HP:0001552)1.86472972
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85067736
99Small epiphyses (HP:0010585)1.84992054
100Rough bone trabeculation (HP:0100670)1.83904113
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83486928
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83244163
103Thoracic kyphosis (HP:0002942)1.83234727
104Malnutrition (HP:0004395)1.83125666
105Large hands (HP:0001176)1.82938412
106Esophageal varix (HP:0002040)1.82142459
107Type I transferrin isoform profile (HP:0003642)1.81198871
108Infantile muscular hypotonia (HP:0008947)1.79902474
109Paraparesis (HP:0002385)1.79098845
110Severe short stature (HP:0003510)1.78979876
111Renal salt wasting (HP:0000127)1.78351884
112Diaphragmatic weakness (HP:0009113)1.77581630
113Acute encephalopathy (HP:0006846)1.76630957
114Abnormality of the renal cortex (HP:0011035)1.76308633
115Tubular atrophy (HP:0000092)1.76039500
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75582753
117Abdominal pain (HP:0002027)1.75579386
118Intrahepatic cholestasis (HP:0001406)1.75517844
119Abnormal hemoglobin (HP:0011902)1.73576823
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73427712
121Dicarboxylic aciduria (HP:0003215)1.73427712
122Abnormality of the odontoid process (HP:0003310)1.73106005
123Tubulointerstitial abnormality (HP:0001969)1.72747290
124Male infertility (HP:0003251)1.72208210
125Prolonged QT interval (HP:0001657)1.71581669
126Insulin-resistant diabetes mellitus (HP:0000831)1.71364811
127Glycosuria (HP:0003076)1.60695013
128Abnormality of urine glucose concentration (HP:0011016)1.60695013
129Hyperalaninemia (HP:0003348)1.59795858
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59795858
131Abnormality of alanine metabolism (HP:0010916)1.59795858
132Abnormality of small intestinal villus morphology (HP:0011472)1.58599276
133Villous atrophy (HP:0011473)1.58599276
134Down-sloping shoulders (HP:0200021)1.57130104
135Rhabdomyolysis (HP:0003201)1.56984962
136Rectal prolapse (HP:0002035)1.56051654
137Increased serum pyruvate (HP:0003542)1.50511005
138Glomerulonephritis (HP:0000099)1.49160547
139Distal lower limb muscle weakness (HP:0009053)1.48603863
140Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.47004430
141Abnormal trabecular bone morphology (HP:0100671)1.45234488
142Abnormal biliary tract morphology (HP:0012440)1.44047894
143Sparse eyelashes (HP:0000653)1.40838873
144Limb-girdle muscle atrophy (HP:0003797)1.40454450
145Glucose intolerance (HP:0000833)1.39744888
146Increased CSF protein (HP:0002922)1.39333334
147Popliteal pterygium (HP:0009756)1.37224296
148Hand muscle atrophy (HP:0009130)1.34365081
149Neoplasm of the pancreas (HP:0002894)1.34273286
150Abnormality of glycolysis (HP:0004366)1.33499385
151Disproportionate short-trunk short stature (HP:0003521)1.33363550
152Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.29411624
153Lower limb hyperreflexia (HP:0002395)1.26791437
154Glossoptosis (HP:0000162)1.25307208
155Gowers sign (HP:0003391)1.24989854
156Abnormality of the vitamin B12 metabolism (HP:0004341)1.23675606
157Bifid uvula (HP:0000193)1.22884261
158Woolly hair (HP:0002224)1.22844491
159Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.22250071
160Glomerulosclerosis (HP:0000096)1.21388775
161Vertebral compression fractures (HP:0002953)1.20673748
162Abnormality of vitamin B metabolism (HP:0004340)1.20653674
163Renal tubular acidosis (HP:0001947)1.20494014
164Epiphyseal dysplasia (HP:0002656)1.19348376
165Abnormality of vitamin metabolism (HP:0100508)1.19037594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.86109666
2LMTK26.85056400
3ERN15.59967988
4EPHA24.93185242
5EIF2AK34.07117965
6MAP2K23.60875829
7INSRR3.41973547
8TRIB32.95948095
9STK242.82517098
10PKN22.67606706
11MAP3K122.53220863
12FRK2.43997193
13MAPKAPK32.21537356
14GRK12.03198352
15SCYL22.01641895
16OXSR11.98963993
17MAPK151.89365234
18ZAP701.87183953
19TAOK31.85030124
20PRKG21.57876627
21NME11.55420133
22EIF2AK11.51417245
23PAK21.48674385
24FLT31.47585118
25MAP2K11.45830282
26IRAK31.43558263
27NME21.43084165
28MST41.32829098
29WNK41.28246895
30MAP3K61.27137669
31BMPR1B1.26367305
32PIK3CG1.25495392
33RPS6KB21.23224967
34VRK21.22927854
35NLK1.19085875
36PTK61.18044168
37DAPK11.10831963
38ERBB41.04431185
39MAP3K21.02412575
40PDGFRB1.02117306
41EEF2K1.01101045
42DYRK1A1.00039000
43CAMKK20.96605729
44CAMKK10.94246395
45MYLK0.88041862
46TESK10.85510507
47SIK10.83049072
48DAPK20.81211331
49PASK0.80507415
50PIK3CA0.78395336
51MAPK70.78224012
52MAP2K60.73902010
53DYRK1B0.73173907
54NTRK10.69903768
55IRAK20.69828851
56SRPK10.69686186
57PRKCH0.69252843
58PDK20.68733428
59ICK0.68685366
60CDK80.68334733
61MAP3K10.64373075
62MTOR0.63200637
63TGFBR20.62183667
64PRKD30.61581927
65STK38L0.58680567
66RET0.57528854
67TRPM70.56675974
68PRKCE0.55396238
69HIPK20.54402814
70SGK30.54007027
71LATS10.53883949
72RPS6KB10.52442662
73STK30.48587321
74PDPK10.48546310
75MELK0.46544616
76ACVR1B0.46527534
77PDGFRA0.45102457
78MAP3K140.45028216
79FER0.44439150
80STK390.44169100
81PRKCI0.42700817
82EPHA30.41943718
83PDK10.41559715
84MAPK120.41146442
85PINK10.39918861
86PRKCZ0.39542731
87PRKCD0.39031894
88IRAK40.38465859
89MET0.38186482
90MAP3K50.36894876
91JAK20.36537958
92KSR20.36273067
93JAK10.35648804
94NTRK30.35648531
95IKBKE0.33873450
96PTK20.32221694
97NEK60.31530691
98MAPK30.30971177
99ROCK10.30895451
100PRKCQ0.30602017
101RIPK10.30532328
102CLK10.30122277
103MAP3K90.29893022
104DAPK30.29764552
105EPHB10.29432550
106DYRK20.29412605
107ERBB30.27945935
108PRKACB0.27815079
109LRRK20.27609928
110MAP3K30.26510454
111PRKD10.26025498
112TAOK20.25995084
113AKT20.24887379
114PRKCA0.24872029
115ADRBK20.24528169
116IRAK10.24465100
117IKBKB0.24305535
118STK380.23181949
119PDK30.21445808
120PDK40.21445808
121IGF1R0.20021641
122FGFR40.19901492
123SGK20.19180761
124ILK0.19083531
125RPS6KA10.19004309
126BRAF0.18732999
127VRK10.18644777
128TBK10.18430738
129CSNK1A10.18127844
130NEK90.17328748
131CAMK1D0.16763740
132CHUK0.16678074
133TSSK60.16580027
134ABL10.15495468
135GSK3A0.14508385
136CDK190.14111710
137MAPK110.14107931
138MAPK10.14093894
139MAP3K70.13880433
140GRK50.12801055
141MST1R0.12506136
142EGFR0.12296324
143PRKAA10.12167058
144CSNK1G20.11987125
145PRKACA0.10725338
146STK160.10720206
147MAP3K80.10253251
148PIM20.08940412
149AKT10.08563685
150PRKACG0.08508173

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049727.80501676
2Fat digestion and absorption_Homo sapiens_hsa049755.94514423
3* Protein digestion and absorption_Homo sapiens_hsa049744.95347667
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.90821371
5Protein export_Homo sapiens_hsa030603.84150473
6Folate biosynthesis_Homo sapiens_hsa007903.16933610
7Glycerolipid metabolism_Homo sapiens_hsa005612.86625306
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.69565734
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.60077481
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.54798482
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12369717
12Steroid biosynthesis_Homo sapiens_hsa001001.91265476
13Vitamin digestion and absorption_Homo sapiens_hsa049771.75835811
14Propanoate metabolism_Homo sapiens_hsa006401.71084962
15Renin-angiotensin system_Homo sapiens_hsa046141.52648879
16Arginine and proline metabolism_Homo sapiens_hsa003301.21628350
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17416748
18Linoleic acid metabolism_Homo sapiens_hsa005911.15454669
19N-Glycan biosynthesis_Homo sapiens_hsa005101.14666702
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11109880
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05280096
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02888569
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00307299
24Selenocompound metabolism_Homo sapiens_hsa004501.00255316
25Biosynthesis of amino acids_Homo sapiens_hsa012300.99428156
26Other glycan degradation_Homo sapiens_hsa005110.97805022
27Sulfur metabolism_Homo sapiens_hsa009200.94155892
28Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92744594
29Insulin secretion_Homo sapiens_hsa049110.92551646
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90646953
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88038044
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87743267
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.83925318
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83682766
35Starch and sucrose metabolism_Homo sapiens_hsa005000.79455941
36Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77464346
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75389657
38Vibrio cholerae infection_Homo sapiens_hsa051100.73709081
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72554563
40Vitamin B6 metabolism_Homo sapiens_hsa007500.71934231
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71688580
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.69032014
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62916819
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62026635
45One carbon pool by folate_Homo sapiens_hsa006700.61813684
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.61397474
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58705795
48beta-Alanine metabolism_Homo sapiens_hsa004100.56626445
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56515641
50Pyruvate metabolism_Homo sapiens_hsa006200.54560220
51Notch signaling pathway_Homo sapiens_hsa043300.54448050
52Retinol metabolism_Homo sapiens_hsa008300.52471224
53Fructose and mannose metabolism_Homo sapiens_hsa000510.50509003
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48727773
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48671285
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46654016
57Lysosome_Homo sapiens_hsa041420.43696002
58Fatty acid degradation_Homo sapiens_hsa000710.43209118
59Tryptophan metabolism_Homo sapiens_hsa003800.42808243
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42242764
61Mineral absorption_Homo sapiens_hsa049780.39221652
62Regulation of autophagy_Homo sapiens_hsa041400.39055712
63Circadian rhythm_Homo sapiens_hsa047100.37883259
64Arachidonic acid metabolism_Homo sapiens_hsa005900.37630961
65Arginine biosynthesis_Homo sapiens_hsa002200.35433721
66Legionellosis_Homo sapiens_hsa051340.35074999
67Hepatitis C_Homo sapiens_hsa051600.34524863
68Metabolic pathways_Homo sapiens_hsa011000.33927124
69Glutathione metabolism_Homo sapiens_hsa004800.33702729
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33173930
71Complement and coagulation cascades_Homo sapiens_hsa046100.31346212
72Tight junction_Homo sapiens_hsa045300.30889400
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29188669
74Carbon metabolism_Homo sapiens_hsa012000.28730533
75Type I diabetes mellitus_Homo sapiens_hsa049400.28649752
76Sulfur relay system_Homo sapiens_hsa041220.28143254
77Alzheimers disease_Homo sapiens_hsa050100.28090389
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27966648
79Pentose phosphate pathway_Homo sapiens_hsa000300.25775553
80* Influenza A_Homo sapiens_hsa051640.25518969
81Ether lipid metabolism_Homo sapiens_hsa005650.25299074
82Parkinsons disease_Homo sapiens_hsa050120.24297688
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23538926
84Nitrogen metabolism_Homo sapiens_hsa009100.22091721
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19858239
86Galactose metabolism_Homo sapiens_hsa000520.19012942
87Sphingolipid metabolism_Homo sapiens_hsa006000.18821206
88Proteasome_Homo sapiens_hsa030500.17918125
89Calcium signaling pathway_Homo sapiens_hsa040200.16705982
90Cocaine addiction_Homo sapiens_hsa050300.15637437
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.14407119
92Type II diabetes mellitus_Homo sapiens_hsa049300.14307769
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14059799
94Insulin resistance_Homo sapiens_hsa049310.13932321
95mTOR signaling pathway_Homo sapiens_hsa041500.12845093
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10793247
97Fatty acid metabolism_Homo sapiens_hsa012120.10227871
98Ovarian steroidogenesis_Homo sapiens_hsa049130.09840316
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.09799526
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09385607
101VEGF signaling pathway_Homo sapiens_hsa043700.09333206
102Butanoate metabolism_Homo sapiens_hsa006500.09196650
103Peroxisome_Homo sapiens_hsa041460.09087876
104Endometrial cancer_Homo sapiens_hsa052130.08995066
105* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08749623
106Oxidative phosphorylation_Homo sapiens_hsa001900.07683991
107Thyroid hormone synthesis_Homo sapiens_hsa049180.07574614
108Bile secretion_Homo sapiens_hsa049760.06781455
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05701992
110Fatty acid elongation_Homo sapiens_hsa000620.05569278
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.05116881
112Histidine metabolism_Homo sapiens_hsa003400.04995743
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.04709754
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03799109
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03662135
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03092242
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02964195
118Insulin signaling pathway_Homo sapiens_hsa049100.02505424
119Phototransduction_Homo sapiens_hsa047440.02219980
120Prostate cancer_Homo sapiens_hsa052150.01352663
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.01309853
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.01263389
123TGF-beta signaling pathway_Homo sapiens_hsa043500.01154242
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.00464667
125HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0897035
126Tyrosine metabolism_Homo sapiens_hsa00350-0.0890026
127Adherens junction_Homo sapiens_hsa04520-0.0705157
128ABC transporters_Homo sapiens_hsa02010-0.0408944
129Caffeine metabolism_Homo sapiens_hsa00232-0.0218415
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0158124
131Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0143444
132AMPK signaling pathway_Homo sapiens_hsa04152-0.0128209
133Chemical carcinogenesis_Homo sapiens_hsa05204-0.0114480

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