PRSS21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.92138983
2epithelial cilium movement (GO:0003351)9.73271846
3spermatid development (GO:0007286)9.59783123
4motile cilium assembly (GO:0044458)9.28643244
5piRNA metabolic process (GO:0034587)9.15014119
6reproduction (GO:0000003)8.85737627
7regulation of cilium movement (GO:0003352)8.38978751
8cilium movement (GO:0003341)8.30399891
9male meiosis (GO:0007140)8.14560556
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.92695381
11synaptonemal complex organization (GO:0070193)7.87258199
12synaptonemal complex assembly (GO:0007130)7.57816889
13single fertilization (GO:0007338)7.30449105
14negative regulation of inclusion body assembly (GO:0090084)6.97451942
15sperm capacitation (GO:0048240)6.93607962
16* spermatogenesis (GO:0007283)6.43174932
17* male gamete generation (GO:0048232)6.40963053
18fertilization (GO:0009566)6.35519925
19organic cation transport (GO:0015695)6.11633708
20* gamete generation (GO:0007276)5.88985184
21DNA methylation involved in gamete generation (GO:0043046)5.73207578
22regulation of inclusion body assembly (GO:0090083)5.72053732
23male meiosis I (GO:0007141)5.69888443
24microtubule depolymerization (GO:0007019)5.59747353
25ventricular system development (GO:0021591)5.52009315
26germ cell development (GO:0007281)5.48989732
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.45406232
28seminiferous tubule development (GO:0072520)5.27613897
29calcium ion-dependent exocytosis (GO:0017156)5.20372249
30chromosome organization involved in meiosis (GO:0070192)5.19847072
31regulation of microtubule-based movement (GO:0060632)5.04464097
32cell recognition (GO:0008037)4.99664820
33meiotic nuclear division (GO:0007126)4.80995736
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.67974802
35* multicellular organismal reproductive process (GO:0048609)4.61845892
36microtubule severing (GO:0051013)4.61540122
37meiosis I (GO:0007127)4.59357928
38chromosome condensation (GO:0030261)4.56585064
39left/right pattern formation (GO:0060972)4.56534645
40DNA packaging (GO:0006323)4.45308120
41DNA strand elongation involved in DNA replication (GO:0006271)4.39115084
42telomere maintenance via semi-conservative replication (GO:0032201)4.27450589
43meiotic cell cycle (GO:0051321)4.20256106
44DNA strand elongation (GO:0022616)4.18053214
45DNA unwinding involved in DNA replication (GO:0006268)4.15834653
46ribosomal small subunit assembly (GO:0000028)4.15225074
47glycerol ether metabolic process (GO:0006662)4.13978578
48protein localization to cilium (GO:0061512)3.98199369
49chaperone-mediated protein complex assembly (GO:0051131)3.94248962
50folic acid metabolic process (GO:0046655)3.93229598
51purine nucleobase biosynthetic process (GO:0009113)3.89544766
52genitalia morphogenesis (GO:0035112)3.89144773
53DNA replication initiation (GO:0006270)3.87306769
54regulation of translational fidelity (GO:0006450)3.84228515
55ether metabolic process (GO:0018904)3.82049477
56nucleobase biosynthetic process (GO:0046112)3.81835166
57spermatid nucleus differentiation (GO:0007289)3.81116020
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.79398373
59multicellular organismal development (GO:0007275)3.79318022
60oxidative phosphorylation (GO:0006119)3.77820486
61protein polyglutamylation (GO:0018095)3.66765676
62viral transcription (GO:0019083)3.65548396
63formation of translation preinitiation complex (GO:0001731)3.65324341
64telomere maintenance via recombination (GO:0000722)3.63238112
65sequestering of actin monomers (GO:0042989)3.54914125
66translational termination (GO:0006415)3.52885689
67ribosomal small subunit biogenesis (GO:0042274)3.52111765
68rRNA modification (GO:0000154)3.48017972
69ribosomal large subunit biogenesis (GO:0042273)3.45943453
70DNA replication checkpoint (GO:0000076)3.43834594
71nuclear pore complex assembly (GO:0051292)3.42961303
72maturation of SSU-rRNA (GO:0030490)3.42638949
73monoubiquitinated protein deubiquitination (GO:0035520)3.42141329
74amino-acid betaine transport (GO:0015838)3.41042370
75carnitine transport (GO:0015879)3.41042370
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40813012
77mitotic recombination (GO:0006312)3.40155000
78intraciliary transport (GO:0042073)3.35854972
79IMP biosynthetic process (GO:0006188)3.33804353
80carnitine transmembrane transport (GO:1902603)3.33067233
81aerobic respiration (GO:0009060)3.30763812
82axoneme assembly (GO:0035082)3.28820652
83regulation of spindle checkpoint (GO:0090231)3.27572494
84negative regulation of organelle assembly (GO:1902116)3.26505136
85DNA topological change (GO:0006265)3.26014422
86gene silencing by RNA (GO:0031047)3.25756167
87ribonucleoprotein complex biogenesis (GO:0022613)3.25543174
88negative regulation of erythrocyte differentiation (GO:0045647)3.24678831
89translational elongation (GO:0006414)3.24645295
90lactate metabolic process (GO:0006089)3.23784338
91folic acid-containing compound biosynthetic process (GO:0009396)3.19720094
92positive regulation of B cell differentiation (GO:0045579)3.17620201
93ribosome biogenesis (GO:0042254)3.17451956
94purine nucleotide salvage (GO:0032261)3.16529989
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14669234
96nucleoside diphosphate phosphorylation (GO:0006165)3.12934295
97microtubule-based movement (GO:0007018)3.11144989
98mitotic nuclear envelope disassembly (GO:0007077)3.10914560
99meiotic cell cycle process (GO:1903046)3.10778438
100alditol metabolic process (GO:0019400)3.10546402
101translational initiation (GO:0006413)3.09131875
102protein refolding (GO:0042026)3.08518882
103pseudouridine synthesis (GO:0001522)3.08381239
104viral mRNA export from host cell nucleus (GO:0046784)3.07972902
105rRNA methylation (GO:0031167)3.07512556
106nucleobase-containing small molecule interconversion (GO:0015949)3.06918369
107negative regulation of B cell apoptotic process (GO:0002903)3.05710659
108synapsis (GO:0007129)3.05317008
109mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04949518
110cotranslational protein targeting to membrane (GO:0006613)3.04017249
111protein targeting to ER (GO:0045047)3.02897347
112purine nucleobase metabolic process (GO:0006144)3.01385742
113nucleotide-excision repair, DNA gap filling (GO:0006297)3.00888805
114pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.98090926
115pyrimidine nucleotide catabolic process (GO:0006244)2.98015566
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97990483
117mitotic sister chromatid cohesion (GO:0007064)2.97580199
118glycolytic process (GO:0006096)2.97043812
119nuclear pore organization (GO:0006999)2.94679111
120regulation of mitochondrial translation (GO:0070129)2.94646150
121ribosome assembly (GO:0042255)2.94401741
122deoxyribose phosphate biosynthetic process (GO:0046385)2.92244296
1232-deoxyribonucleotide biosynthetic process (GO:0009265)2.92244296
124microtubule polymerization or depolymerization (GO:0031109)2.91637498
125DNA synthesis involved in DNA repair (GO:0000731)2.91578753
126protein localization to endoplasmic reticulum (GO:0070972)2.90203218
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90076084
128IMP metabolic process (GO:0046040)2.89981119
129cilium organization (GO:0044782)2.89061226
130nucleus organization (GO:0006997)2.88357771
131sexual reproduction (GO:0019953)2.88245455
132GTP biosynthetic process (GO:0006183)2.86773284
133polyol catabolic process (GO:0046174)2.85414777
134viral life cycle (GO:0019058)2.84504301
135pore complex assembly (GO:0046931)2.83289351
136telomere maintenance via telomere lengthening (GO:0010833)2.82431741
137nuclear envelope disassembly (GO:0051081)2.80427253
138membrane disassembly (GO:0030397)2.80427253
139pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.80085002
140cilium morphogenesis (GO:0060271)2.80051592
141single strand break repair (GO:0000012)2.79946523
142definitive hemopoiesis (GO:0060216)2.79436457
143cellular protein complex disassembly (GO:0043624)2.78518014
144interferon-gamma secretion (GO:0072643)2.78244535
145protoporphyrinogen IX metabolic process (GO:0046501)2.77319347
146GMP metabolic process (GO:0046037)2.76217718
147mitotic sister chromatid segregation (GO:0000070)2.76080335
148nucleotide salvage (GO:0043173)2.75816161
149protein K11-linked deubiquitination (GO:0035871)2.75603375
150rRNA processing (GO:0006364)2.75580674
151ATP synthesis coupled proton transport (GO:0015986)2.74788464
152energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74788464
153cilium assembly (GO:0042384)2.74007706
154cellular component assembly involved in morphogenesis (GO:0010927)2.73795672
155regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.73659407
156cellular component biogenesis (GO:0044085)2.73637779
157proteasome assembly (GO:0043248)2.73473220
158positive regulation of megakaryocyte differentiation (GO:0045654)2.72983518
159mitotic chromosome condensation (GO:0007076)2.72931791
160peptidyl-glutamic acid modification (GO:0018200)2.72024428
161UV protection (GO:0009650)2.71040798
162negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70880856
163RNA localization (GO:0006403)2.68167365
164tRNA methylation (GO:0030488)2.67709787
165pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.67469384
166deoxyribose phosphate catabolic process (GO:0046386)2.67409111
167glycerol metabolic process (GO:0006071)2.66624406
168deoxyribonucleotide catabolic process (GO:0009264)2.66238846
169folic acid-containing compound metabolic process (GO:0006760)2.65789399
170protein complex disassembly (GO:0043241)2.65513793
171rRNA metabolic process (GO:0016072)2.65229721
172meiotic chromosome segregation (GO:0045132)2.63350177
173translation (GO:0006412)2.61674411
174guanosine-containing compound biosynthetic process (GO:1901070)2.60951668
175regulation of centriole replication (GO:0046599)2.59418904
176anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.59210369
1772-deoxyribonucleotide metabolic process (GO:0009394)2.58911602
178gene silencing (GO:0016458)2.58580603
179regulation of protein polyubiquitination (GO:1902914)2.58231873
180base-excision repair (GO:0006284)2.57830866
181tRNA aminoacylation for protein translation (GO:0006418)2.57317521
182UTP biosynthetic process (GO:0006228)2.56582730
183regulation of cilium assembly (GO:1902017)2.56432209
184positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55475831
185negative regulation of ligase activity (GO:0051352)2.55258793
186negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.55258793
187purine-containing compound salvage (GO:0043101)2.54386192
188regulation of meiosis I (GO:0060631)2.50017011
189sperm motility (GO:0030317)13.1604525
190fusion of sperm to egg plasma membrane (GO:0007342)13.0485319
191cilium or flagellum-dependent cell motility (GO:0001539)12.2771277
192acrosome reaction (GO:0007340)11.6481167
193sperm-egg recognition (GO:0035036)11.4399797
194acrosome assembly (GO:0001675)11.3695085
195cell wall macromolecule metabolic process (GO:0044036)10.6660750
196cell wall macromolecule catabolic process (GO:0016998)10.6660750
197binding of sperm to zona pellucida (GO:0007339)10.6552113
198multicellular organism reproduction (GO:0032504)10.5644967
199axonemal dynein complex assembly (GO:0070286)10.3087834
200cell-cell recognition (GO:0009988)10.2521301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.30295833
2EZH2_22144423_ChIP-Seq_EOC_Human5.57365769
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.44000648
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.84283258
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73590874
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.29633139
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19220426
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95426821
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91847589
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90431368
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85371623
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75158244
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69406013
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47833136
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.46317890
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45433829
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42721513
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35842073
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.33267659
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31083343
21XRN2_22483619_ChIP-Seq_HELA_Human2.28285297
22ZNF274_21170338_ChIP-Seq_K562_Hela2.27380938
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.24260716
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19796386
25CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.16225668
26GATA1_26923725_Chip-Seq_HPCs_Mouse2.10267994
27DCP1A_22483619_ChIP-Seq_HELA_Human2.08162196
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07437768
29MYC_22102868_ChIP-Seq_BL_Human2.06158911
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.03939599
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00905551
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.6193122
33VDR_21846776_ChIP-Seq_THP-1_Human1.93931639
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93872826
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93872820
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.92962644
37VDR_22108803_ChIP-Seq_LS180_Human1.91176276
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90768803
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.90606824
40* ZNF263_19887448_ChIP-Seq_K562_Human1.87578727
41FOXP3_21729870_ChIP-Seq_TREG_Human1.86158267
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84728999
43TTF2_22483619_ChIP-Seq_HELA_Human1.80300063
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79639497
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78988132
46ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78885718
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75400563
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.72783660
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71452856
50VDR_23849224_ChIP-Seq_CD4+_Human1.67554171
51KDM5A_27292631_Chip-Seq_BREAST_Human1.65866449
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63536835
53GABP_19822575_ChIP-Seq_HepG2_Human1.62426216
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.62082818
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62011979
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61939229
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60709293
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.58665043
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57927350
60STAT1_17558387_ChIP-Seq_HELA_Human1.57099493
61CIITA_25753668_ChIP-Seq_RAJI_Human1.54561785
62SCL_19346495_ChIP-Seq_HPC-7_Human1.52558684
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51135893
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51127406
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50694194
66SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50523814
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.50313038
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49086537
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48812759
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48785624
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48283356
72NCOR1_26117541_ChIP-Seq_K562_Human1.44041158
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43472754
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.43052904
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.42830106
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.42186928
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42166140
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41618813
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40799808
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38567002
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37410321
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36988993
83CBP_20019798_ChIP-Seq_JUKART_Human1.36684135
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36684135
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36193130
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36023893
87REST_21632747_ChIP-Seq_MESCs_Mouse1.35604326
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35216538
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34006392
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33506413
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32680516
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32069154
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30658068
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.28872027
95LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28304130
96FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28183212
97KDM2B_26808549_Chip-Seq_REH_Human1.28156408
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28149372
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27097248
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26306805
101SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26069769
102P53_21459846_ChIP-Seq_SAOS-2_Human1.25075560
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24994506
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23610644
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22712645
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22528022
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21594495
108SPI1_23547873_ChIP-Seq_NB4_Human1.20228557
109RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19990594
110KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18879323
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18721218
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.18281583
113ELK1_19687146_ChIP-ChIP_HELA_Human1.18275407
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18100706
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18100706
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17658140
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.17600943
118TFEB_21752829_ChIP-Seq_HELA_Human1.16466825
119GATA3_21867929_ChIP-Seq_TH1_Mouse1.16371706
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16158816
121SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14106485
122GF1_26923725_Chip-Seq_HPCs_Mouse1.11701970
123ERG_20517297_ChIP-Seq_VCAP_Human1.10892741
124CBX2_27304074_Chip-Seq_ESCs_Mouse1.10703177
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08986416
126MAF_26560356_Chip-Seq_TH1_Human1.08256809
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08219701
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06671972
129YY1_22570637_ChIP-Seq_MALME-3M_Human1.06646949
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04894169
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04326961
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04170811
133PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04098781
134SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03543672
135MYC_27129775_Chip-Seq_CORNEA_Mouse1.03141326
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02985335
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02695110
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02608775
139* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02523242
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02450216
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02117217
142ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01878754
143* P68_20966046_ChIP-Seq_HELA_Human1.01364295
144MAF_26560356_Chip-Seq_TH2_Human1.01205221
145UTX_26944678_Chip-Seq_JUKART_Human1.01146333
146NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00770316
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00565854
148KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00555721
149STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00465387
150IRF8_22096565_ChIP-ChIP_GC-B_Human1.00003807
151RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99998814
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99992872
153CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99666643
154GATA1_22025678_ChIP-Seq_K562_Human0.99296093
155MYB_26560356_Chip-Seq_TH2_Human0.99214207
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99198432
157RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98443150
158* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98171802
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98122381
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97585263
161GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97585123
162TET1_21451524_ChIP-Seq_MESCs_Mouse0.97101069
163* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97053389
164ESET_19884257_ChIP-Seq_ESCs_Mouse0.96586865
165STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96168024
166SPI1_26923725_Chip-Seq_HPCs_Mouse0.95678254
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95128216
168CRX_20693478_ChIP-Seq_RETINA_Mouse0.94600068
169AR_21909140_ChIP-Seq_LNCAP_Human0.94005320
170TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93202807
171CTCF_20526341_ChIP-Seq_ESCs_Human0.92888728
172EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92864056
173LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92486677
174* RARA_24833708_ChIP-Seq_LIVER_Mouse0.91999273
175CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91010662
176NANOG_18555785_Chip-Seq_ESCs_Mouse0.90998969
177CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89633592
178FLI1_21867929_ChIP-Seq_CD8_Mouse0.89163992
179PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89039873
180ELF1_20517297_ChIP-Seq_JURKAT_Human0.88691956
181PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88226038
182GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87031350
183JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86491138
184RNF2_27304074_Chip-Seq_NSC_Mouse0.86428241
185SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86253647
186SOX9_26525672_Chip-Seq_HEART_Mouse0.85116113
187OCT4_18555785_Chip-Seq_ESCs_Mouse0.85009468
188SOX11_22085726_ChIP-Seq_ESNs_Mouse0.83825896
189MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82999969
190P53_22387025_ChIP-Seq_ESCs_Mouse0.82270998
191OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82222888
192NANOG_20526341_ChIP-Seq_ESCs_Human0.81620326
193* SOX2_21211035_ChIP-Seq_LN229_Human0.81471855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.98217706
2* MP0001929_abnormal_gametogenesis5.48037606
3MP0008877_abnormal_DNA_methylation4.60156829
4MP0003806_abnormal_nucleotide_metabolis3.72481791
5MP0002396_abnormal_hematopoietic_system3.67310467
6MP0002210_abnormal_sex_determination3.54398654
7MP0002161_abnormal_fertility/fecundity3.27028207
8MP0003693_abnormal_embryo_hatching3.24041121
9MP0004957_abnormal_blastocyst_morpholog3.02543600
10MP0001145_abnormal_male_reproductive2.99986261
11MP0002653_abnormal_ependyma_morphology2.84673764
12MP0004147_increased_porphyrin_level2.63722248
13MP0000653_abnormal_sex_gland2.58570221
14MP0002877_abnormal_melanocyte_morpholog2.44504312
15MP0005451_abnormal_body_composition2.39385452
16MP0009697_abnormal_copulation2.37470150
17MP0003718_maternal_effect2.22762178
18MP0005670_abnormal_white_adipose2.22496449
19MP0008932_abnormal_embryonic_tissue2.02323368
20* MP0005410_abnormal_fertilization15.9827079
21MP0003646_muscle_fatigue1.95908660
22MP0002160_abnormal_reproductive_system1.92361886
23MP0005623_abnormal_meninges_morphology1.83281277
24MP0002132_abnormal_respiratory_system1.80426711
25MP0003186_abnormal_redox_activity1.79287694
26MP0003656_abnormal_erythrocyte_physiolo1.77497774
27MP0002019_abnormal_tumor_incidence1.74825727
28MP0003763_abnormal_thymus_physiology1.70066368
29MP0005464_abnormal_platelet_physiology1.69356019
30MP0009333_abnormal_splenocyte_physiolog1.66138951
31MP0001835_abnormal_antigen_presentation1.56219059
32MP0002398_abnormal_bone_marrow1.48817673
33MP0000350_abnormal_cell_proliferation1.47762666
34MP0001853_heart_inflammation1.39960213
35MP0005083_abnormal_biliary_tract1.38829680
36MP0001873_stomach_inflammation1.38629865
37MP0000678_abnormal_parathyroid_gland1.35608406
38MP0002722_abnormal_immune_system1.32302774
39MP0004233_abnormal_muscle_weight1.29650073
40MP0000372_irregular_coat_pigmentation1.27335162
41MP0000703_abnormal_thymus_morphology1.27256001
42MP0002282_abnormal_trachea_morphology1.26546935
43MP0005058_abnormal_lysosome_morphology1.25069730
44MP0002429_abnormal_blood_cell1.23146907
45MP0000465_gastrointestinal_hemorrhage1.20178146
46MP0008057_abnormal_DNA_replication1.18712633
47MP0000689_abnormal_spleen_morphology1.18067680
48MP0000490_abnormal_crypts_of1.17704615
49MP0009046_muscle_twitch1.16716266
50MP0002148_abnormal_hypersensitivity_rea1.14161168
51MP0001881_abnormal_mammary_gland1.13761868
52MP0002080_prenatal_lethality1.13228247
53MP0000681_abnormal_thyroid_gland1.08469382
54MP0002166_altered_tumor_susceptibility1.06187792
55MP0005647_abnormal_sex_gland1.05222672
56MP0001984_abnormal_olfaction1.04774865
57MP0005075_abnormal_melanosome_morpholog1.04671774
58MP0008058_abnormal_DNA_repair1.03014015
59MP0001765_abnormal_ion_homeostasis1.02515646
60MP0001348_abnormal_lacrimal_gland1.02031494
61MP0005389_reproductive_system_phenotype0.97931958
62MP0000716_abnormal_immune_system0.97710496
63MP0003329_amyloid_beta_deposits0.96954345
64MP0001697_abnormal_embryo_size0.96026017
65MP0002420_abnormal_adaptive_immunity0.93634246
66MP0001819_abnormal_immune_cell0.92021880
67MP0003436_decreased_susceptibility_to0.88990422
68MP0005584_abnormal_enzyme/coenzyme_acti0.87175207
69MP0008873_increased_physiological_sensi0.86717789
70MP0008995_early_reproductive_senescence0.84579746
71MP0003984_embryonic_growth_retardation0.82106338
72MP0003011_delayed_dark_adaptation0.81878869
73MP0005330_cardiomyopathy0.81230673
74MP0005380_embryogenesis_phenotype0.80982885
75MP0001672_abnormal_embryogenesis/_devel0.80982885
76MP0005000_abnormal_immune_tolerance0.80836383
77MP0010094_abnormal_chromosome_stability0.80780009
78MP0002723_abnormal_immune_serum0.80392737
79MP0000013_abnormal_adipose_tissue0.80008530
80MP0002006_tumorigenesis0.77621141
81MP0002419_abnormal_innate_immunity0.77395288
82MP0005025_abnormal_response_to0.76671760
83MP0002088_abnormal_embryonic_growth/wei0.75893460
84MP0009931_abnormal_skin_appearance0.75766813
85MP0000003_abnormal_adipose_tissue0.74264984
86MP0002970_abnormal_white_adipose0.74066147
87MP0008875_abnormal_xenobiotic_pharmacok0.73850396
88MP0005384_cellular_phenotype0.73709819
89MP0002452_abnormal_antigen_presenting0.73703801
90MP0002009_preneoplasia0.73063118
91MP0005266_abnormal_metabolism0.70686991
92MP0003115_abnormal_respiratory_system0.70555949
93MP0000598_abnormal_liver_morphology0.70292702
94MP0005174_abnormal_tail_pigmentation0.69089980
95MP0005319_abnormal_enzyme/_coenzyme0.69039830
96MP0005397_hematopoietic_system_phenotyp0.67867028
97MP0001545_abnormal_hematopoietic_system0.67867028
98MP0002086_abnormal_extraembryonic_tissu0.67690699
99MP0008007_abnormal_cellular_replicative0.67593233
100MP0001800_abnormal_humoral_immune0.67283840
101MP0001764_abnormal_homeostasis0.64602589
102MP0000358_abnormal_cell_content/0.62393391
103MP0000569_abnormal_digit_pigmentation0.60263018
104MP0009278_abnormal_bone_marrow0.59733283
105MP0005636_abnormal_mineral_homeostasis0.56735696
106MP0004036_abnormal_muscle_relaxation0.56242932
107MP0001529_abnormal_vocalization0.56217425
108MP0002234_abnormal_pharynx_morphology0.55679395
109MP0005377_hearing/vestibular/ear_phenot0.52901383
110MP0003878_abnormal_ear_physiology0.52901383
111MP0000604_amyloidosis0.50972511
112MP0006036_abnormal_mitochondrial_physio0.50153024
113MP0003786_premature_aging0.49351997
114MP0001324_abnormal_eye_pigmentation0.46581684
115MP0003111_abnormal_nucleus_morphology0.44820106
116MP0005666_abnormal_adipose_tissue0.44812234
117MP0005551_abnormal_eye_electrophysiolog0.44405486
118MP0004133_heterotaxia0.44125292
119MP0003699_abnormal_female_reproductive0.43089738
120MP0003880_abnormal_central_pattern0.42889737
121MP0003879_abnormal_hair_cell0.41733658
122MP0003950_abnormal_plasma_membrane0.41467216
123MP0006035_abnormal_mitochondrial_morpho0.40505352
124MP0005253_abnormal_eye_physiology0.40218630
125MP0004808_abnormal_hematopoietic_stem0.36865704
126MP0004019_abnormal_vitamin_homeostasis0.34129358
127MP0004043_abnormal_pH_regulation0.33790868
128MP0001730_embryonic_growth_arrest0.33301521
129MP0001727_abnormal_embryo_implantation0.33067482
130MP0000751_myopathy0.33034407
131MP0000534_abnormal_ureter_morphology0.32466759
132MP0000920_abnormal_myelination0.32398939
133MP0004134_abnormal_chest_morphology0.30723493
134MP0002269_muscular_atrophy0.30254032
135MP0004811_abnormal_neuron_physiology0.29319505
136MP0003633_abnormal_nervous_system0.28693237
137MP0001661_extended_life_span0.28392567
138MP0003631_nervous_system_phenotype0.28392349
139MP0002928_abnormal_bile_duct0.28030012
140MP0002295_abnormal_pulmonary_circulatio0.27204337
141MP0005391_vision/eye_phenotype0.26844042
142MP0008569_lethality_at_weaning0.25999839
143MP0003861_abnormal_nervous_system0.24872299
144MP0002152_abnormal_brain_morphology0.23755414
145MP0001440_abnormal_grooming_behavior0.23331211
146MP0002822_catalepsy0.22941872
147MP0002139_abnormal_hepatobiliary_system0.22071081
148MP0002169_no_abnormal_phenotype0.21824265
149MP0001293_anophthalmia0.21741555
150MP0001119_abnormal_female_reproductive0.21652422
151MP0002873_normal_phenotype0.21594403
152MP0004270_analgesia0.20749709
153MP0002229_neurodegeneration0.20736666
154MP0009115_abnormal_fat_cell0.20608132
155MP0002272_abnormal_nervous_system0.20518232
156MP0000313_abnormal_cell_death0.19407154
157MP0003045_fibrosis0.19318301
158MP0002736_abnormal_nociception_after0.19152140
159MP0010307_abnormal_tumor_latency0.19080395
160MP0003632_abnormal_nervous_system0.18880515
161MP0002971_abnormal_brown_adipose0.18700051
162MP0003634_abnormal_glial_cell0.16287613
163MP0003948_abnormal_gas_homeostasis0.16207298
164MP0003077_abnormal_cell_cycle0.15593587
165MP0000001_mammalian_phenotype0.15312826
166MP0002405_respiratory_system_inflammati0.14180796
167MP0004145_abnormal_muscle_electrophysio0.14111090
168MP0004742_abnormal_vestibular_system0.14041505
169MP0003942_abnormal_urinary_system0.13924376
170MP0002572_abnormal_emotion/affect_behav0.13613373

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.47408921
2Abnormal respiratory motile cilium morphology (HP:0005938)9.09687275
3Abnormal respiratory epithelium morphology (HP:0012253)9.09687275
4Rhinitis (HP:0012384)7.96270003
5Abnormal ciliary motility (HP:0012262)7.53993856
6Chronic bronchitis (HP:0004469)7.29683810
7Infertility (HP:0000789)6.79105339
8Nasal polyposis (HP:0100582)6.51643634
9Abnormality of the nasal mucosa (HP:0000433)5.34569374
10Bronchitis (HP:0012387)4.59740050
11Bronchiectasis (HP:0002110)4.57403077
12Nephronophthisis (HP:0000090)4.44978466
13Microvesicular hepatic steatosis (HP:0001414)3.94034076
14Male infertility (HP:0003251)3.80246064
15Abnormality of cells of the erythroid lineage (HP:0012130)3.65916201
16Abnormal number of erythroid precursors (HP:0012131)3.56641452
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.55594769
18Abnormal mitochondria in muscle tissue (HP:0008316)3.54577090
19Chromsome breakage (HP:0040012)3.49807407
20Reticulocytopenia (HP:0001896)3.42474998
21Recurrent sinusitis (HP:0011108)3.41376852
22Recurrent otitis media (HP:0000403)3.38303734
23Abnormality of the renal medulla (HP:0100957)3.38121840
24Ragged-red muscle fibers (HP:0003200)3.36370191
25Abnormal spermatogenesis (HP:0008669)3.29029514
26Abnormality of glycolysis (HP:0004366)3.26678039
27Hepatocellular necrosis (HP:0001404)3.23143897
28Hyperthyroidism (HP:0000836)3.22228068
29Increased serum pyruvate (HP:0003542)3.17199899
30Pallor (HP:0000980)3.07748728
31Cerebral edema (HP:0002181)3.06860790
32Truncus arteriosus (HP:0001660)3.06740834
33Type I transferrin isoform profile (HP:0003642)3.05278481
34Hypertensive crisis (HP:0100735)3.04309220
35Progressive muscle weakness (HP:0003323)3.04041557
36Gonadotropin excess (HP:0000837)2.98307623
37Hepatic necrosis (HP:0002605)2.98148130
38Acute necrotizing encephalopathy (HP:0006965)2.94981746
39Birth length less than 3rd percentile (HP:0003561)2.94422575
40Acute encephalopathy (HP:0006846)2.93786089
41Seborrheic dermatitis (HP:0001051)2.93198587
42Abnormality of reticulocytes (HP:0004312)2.92708134
43Tubulointerstitial nephritis (HP:0001970)2.90135892
44Abnormality of T cell physiology (HP:0011840)2.88172854
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.86925998
46Abnormality of the lower motor neuron (HP:0002366)2.86236859
47Increased CSF lactate (HP:0002490)2.82801431
48Aplastic anemia (HP:0001915)2.81949380
49Myelodysplasia (HP:0002863)2.80848487
50Recurrent bronchitis (HP:0002837)2.79777543
51Mitochondrial inheritance (HP:0001427)2.78228454
52Thrombocytosis (HP:0001894)2.70738270
53Increased intramyocellular lipid droplets (HP:0012240)2.69916636
54Reticulocytosis (HP:0001923)2.69134357
55Increased serum lactate (HP:0002151)2.68856041
56Chronic obstructive pulmonary disease (HP:0006510)2.68422286
57Obstructive lung disease (HP:0006536)2.68422286
58Fatigue (HP:0012378)2.68336123
59Panhypogammaglobulinemia (HP:0003139)2.67209510
60Autoimmune hemolytic anemia (HP:0001890)2.58896756
61Tubular atrophy (HP:0000092)2.58311470
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57260120
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57260120
64Petechiae (HP:0000967)2.57165853
65Elevated erythrocyte sedimentation rate (HP:0003565)2.56819483
66Molar tooth sign on MRI (HP:0002419)2.56261988
67Abnormality of midbrain morphology (HP:0002418)2.56261988
68Aplasia/Hypoplasia of the thymus (HP:0010515)2.53503136
69Increased muscle lipid content (HP:0009058)2.53325972
70Impulsivity (HP:0100710)2.52918287
71Tubulointerstitial abnormality (HP:0001969)2.51141294
72Abnormal protein glycosylation (HP:0012346)2.50752194
73Abnormal glycosylation (HP:0012345)2.50752194
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50752194
75Abnormal protein N-linked glycosylation (HP:0012347)2.50752194
76Hypoparathyroidism (HP:0000829)2.49023198
77Autoimmune thrombocytopenia (HP:0001973)2.46664882
78Lactic acidosis (HP:0003128)2.41585516
79Macrocytic anemia (HP:0001972)2.39430570
80Abnormality of the preputium (HP:0100587)2.38456417
81Acute lymphatic leukemia (HP:0006721)2.37345325
82Granulocytopenia (HP:0001913)2.36930279
83Abnormality of pyrimidine metabolism (HP:0004353)2.34692179
84Amyotrophic lateral sclerosis (HP:0007354)2.34126828
85Duplicated collecting system (HP:0000081)2.33671161
86Pancytopenia (HP:0001876)2.32980187
87Exercise intolerance (HP:0003546)2.31801253
88Acute myeloid leukemia (HP:0004808)2.31431963
89Neurodegeneration (HP:0002180)2.31034725
90Azoospermia (HP:0000027)2.29598801
91Abnormality of the tricuspid valve (HP:0001702)2.29209636
92Hyperammonemia (HP:0001987)2.27577642
93Agammaglobulinemia (HP:0004432)2.24995346
94Medial flaring of the eyebrow (HP:0010747)2.24959247
95Progressive macrocephaly (HP:0004481)2.24815034
96Multiple enchondromatosis (HP:0005701)2.22398634
97Abnormal gallbladder physiology (HP:0012438)2.20910292
98Cholecystitis (HP:0001082)2.20910292
99Squamous cell carcinoma (HP:0002860)2.18583667
100Esophageal neoplasm (HP:0100751)2.18107162
101Neoplasm of head and neck (HP:0012288)2.18107162
102Testicular atrophy (HP:0000029)2.15542457
103Rhabdomyolysis (HP:0003201)2.12613858
104Hypergonadotropic hypogonadism (HP:0000815)2.12567409
105Recurrent viral infections (HP:0004429)2.12298990
106Reduced antithrombin III activity (HP:0001976)2.09088814
107Dicarboxylic aciduria (HP:0003215)2.08839477
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08839477
109Abnormality of cochlea (HP:0000375)2.08825823
110Respiratory difficulties (HP:0002880)2.07980233
111Increased serum ferritin (HP:0003281)2.06107267
112Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05174324
113Tubulointerstitial fibrosis (HP:0005576)2.04898567
114B lymphocytopenia (HP:0010976)2.02800861
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4187960
116Absent/shortened dynein arms (HP:0200106)13.0146792
117Dynein arm defect of respiratory motile cilia (HP:0012255)13.0146792
118Abnormality of B cell number (HP:0010975)1.99601491
119Fibular hypoplasia (HP:0003038)1.99419133
120Abnormality of the renal collecting system (HP:0004742)1.98419522
121Abnormality of the prostate (HP:0008775)1.95579049
122Spastic tetraparesis (HP:0001285)1.95343475
123Abnormality of alanine metabolism (HP:0010916)1.94157435
124Hyperalaninemia (HP:0003348)1.94157435
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94157435
126Premature ovarian failure (HP:0008209)1.93936584
127Abnormality of DNA repair (HP:0003254)1.93726008
128Cholelithiasis (HP:0001081)1.92603018
129Postaxial foot polydactyly (HP:0001830)1.92220874
130Emotional lability (HP:0000712)1.91441197
131Rough bone trabeculation (HP:0100670)1.91070486
132Stage 5 chronic kidney disease (HP:0003774)1.89340295
133Lethargy (HP:0001254)1.88188976
134Bone marrow hypocellularity (HP:0005528)1.86210582
135Abnormal large intestine physiology (HP:0012700)1.84493863
136Lipid accumulation in hepatocytes (HP:0006561)1.83420698
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83199152
138Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81363687
139Polydipsia (HP:0001959)1.79251938
140Abnormal drinking behavior (HP:0030082)1.79251938
141Abnormality of the renal cortex (HP:0011035)1.78520011
142Neurofibrillary tangles (HP:0002185)1.78081131
143Impaired proprioception (HP:0010831)1.77594056
144Dyschromatopsia (HP:0007641)1.75596192
145Congenital hepatic fibrosis (HP:0002612)1.73961002
146Choroideremia (HP:0001139)1.72676800
147Absent frontal sinuses (HP:0002688)1.71416020
148Oculomotor apraxia (HP:0000657)1.67738441
149Short ribs (HP:0000773)1.67548738
150J-shaped sella turcica (HP:0002680)1.66726448
151Renal dysplasia (HP:0000110)1.61964124
152Absent epiphyses (HP:0010577)1.61668927
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61668927
154Chronic sinusitis (HP:0011109)1.57235376
155Upper motor neuron abnormality (HP:0002127)1.56944186
156Abnormality of renal excretion (HP:0011036)1.56777873
157Bell-shaped thorax (HP:0001591)1.55557281
158Abnormality of permanent molar morphology (HP:0011071)1.53502996
159Abnormality of the dental root (HP:0006486)1.53502996
160Taurodontia (HP:0000679)1.53502996
161Abnormality of dentin (HP:0010299)1.53206601
162Decreased central vision (HP:0007663)1.51346706
163Heterotopia (HP:0002282)1.50733155
164Bile duct proliferation (HP:0001408)1.47877000
165Abnormal biliary tract physiology (HP:0012439)1.47877000
166Broad distal phalanx of finger (HP:0009836)1.44884324
167Short femoral neck (HP:0100864)1.44552158
168Deformed sella turcica (HP:0002681)1.42749824
169Abnormality of molar morphology (HP:0011070)1.42236588
170Abnormality of molar (HP:0011077)1.42236588
171Degeneration of anterior horn cells (HP:0002398)1.40939062
172Abnormality of the anterior horn cell (HP:0006802)1.40939062
173Microglossia (HP:0000171)1.40169996
174Abnormality of the dental pulp (HP:0006479)1.40144382
175Cerebral inclusion bodies (HP:0100314)1.39481665
176Postaxial hand polydactyly (HP:0001162)1.39011872
177Hemorrhage of the eye (HP:0011885)1.34019017
178Loss of speech (HP:0002371)1.33798113
179Nephropathy (HP:0000112)1.32396061
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.30057750
181Short thorax (HP:0010306)1.28678762
182Facial cleft (HP:0002006)1.28645951
183Abnormal urine output (HP:0012590)1.27275597
184Aplasia/Hypoplasia of the lens (HP:0008063)1.23734319
185Supernumerary spleens (HP:0009799)1.22575766
18611 pairs of ribs (HP:0000878)1.22258424
187Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.21459340
188Cystic liver disease (HP:0006706)1.20364485
189Hemiparesis (HP:0001269)1.18701734
190Vascular calcification (HP:0004934)1.18066800
191Aplasia/Hypoplasia of the fibula (HP:0006492)1.17657263
192Exercise-induced myalgia (HP:0003738)1.17413939
193Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.16328602
194Neoplasm of the heart (HP:0100544)1.16106350
195Cerebellar dysplasia (HP:0007033)1.15435541
196Aplasia/Hypoplasia of the tongue (HP:0010295)1.15266815
197Difficulty climbing stairs (HP:0003551)1.13654860
198Easy fatigability (HP:0003388)1.13471145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.18612180
2PDK48.18612180
3TESK16.33098035
4PDK25.27597920
5PRKD34.65238552
6ICK4.18116822
7NME23.83064032
8SCYL23.39513882
9VRK23.11904668
10PBK2.98315100
11EIF2AK12.82801876
12PTK2B2.49544558
13WNK42.42941727
14STK392.40157240
15PNCK2.35449012
16NEK12.22778004
17RPS6KB22.09876228
18MST1R2.03729765
19ERN11.97929873
20PIM21.92400458
21NEK21.89587316
22BCKDK1.80648399
23KDR1.78058073
24SRPK11.72840217
25STK381.68778608
26FLT31.65430892
27RAF11.65043997
28TAOK31.63385103
29NME11.44808325
30BMPR21.42257216
31DYRK1B1.34527775
32MKNK11.33649247
33MAP4K11.19810553
34IRAK31.14375531
35SMG11.12448250
36VRK11.12431976
37CDK81.09592813
38MAPK151.08735676
39PDK11.05357793
40AURKB1.04896625
41MAP2K31.04875610
42CDK71.04217630
43KIT1.02541827
44STK161.02006762
45WNK11.01002398
46PASK0.95392913
47BRSK20.94752498
48CDK40.92661650
49AURKA0.92143111
50TEC0.88510030
51ARAF0.87799617
52MAP3K80.87527748
53TYRO30.85584240
54ZAK0.85328267
55MAP3K110.85028713
56CAMK1G0.84792483
57JAK30.83131260
58CCNB10.82518136
59BTK0.81262682
60TBK10.80928579
61MAPK110.80075369
62CDK120.79539561
63CAMKK10.78789921
64IRAK10.77674446
65NUAK10.76401175
66DYRK30.74729608
67STK30.73537632
68TSSK60.72498863
69RPS6KA50.70083306
70KSR20.70079042
71EIF2AK30.68858516
72RPS6KA40.68642035
73TTK0.63956759
74PDPK10.62788002
75PIM10.62346801
76TESK20.61030004
77TAOK20.59290582
78ALK0.59145903
79TLK10.57998960
80LRRK20.57628372
81BMX0.54956993
82ABL20.54643918
83MAP3K10.54172786
84PINK10.53425461
85IRAK20.51098496
86RIPK40.50970303
87SYK0.50835226
88EIF2AK20.50708474
89CDC70.48922747
90EEF2K0.48468699
91PLK30.48355875
92CHEK20.47237934
93FES0.46853722
94MAP2K20.44754068
95MUSK0.44644236
96MST40.44526596
97IKBKB0.42961790
98CHEK10.40549756
99ATR0.39006046
100MET0.37868879
101MAP3K130.37737474
102MAP2K60.37071695
103PAK10.34764932
104NTRK20.34338021
105TXK0.33733873
106MAP3K140.32627639
107PAK20.32086319
108MAPKAPK50.31909445
109PRKCG0.31205421
110WEE10.31176246
111ATM0.30724024
112MTOR0.27048707
113LMTK20.26589123
114RPS6KB10.24047883
115MARK20.23351917
116PRKAA10.23210412
117PAK40.19278970
118NEK60.16292087
119EPHB10.15567885
120MARK30.14845739
121RPS6KA20.14597831
122PLK10.13497387
123BMPR1B0.13199611
124PRKCQ0.12651116
125CSF1R0.10624511
126PAK60.10421440
127RPS6KA10.10115066
128PLK40.09981135
129STK38L0.09891065
130PKN10.09665128
131CDK150.09525514
132BRAF0.08503391
133SIK20.07262690
134PRKCZ0.07250312
135CDK11A0.06934621
136CDK180.06618621
137GRK70.05088134
138CSNK2A10.04606998
139CSNK1D0.04505331
140CDK140.03818798
141PRKACG0.03777131
142GSK3B0.03043792
143PRKG10.02959904
144MAP3K100.02463610
145CAMK10.02307500
146CLK10.01882590
147CDK20.01481636
148DAPK10.01430993
149MAPK80.01188205
150PRKCA0.00900011
151CDK10.00716772
152PRKACB0.00661345
153BUB10.00053053
154RPS6KA6-0.0343342
155EGFR-0.0328335
156PRKDC-0.0292994
157RPS6KA3-0.0211200
158PRKCD-0.0155322
159CSNK2A2-0.0129457
160RPS6KC1-0.0128352
161RPS6KL1-0.0128352
162BRSK1-0.0126864
163CDK6-0.0123572
164YES1-0.0119239
165PRKCB-0.0075798
166CAMK2A-0.0068028
167DAPK2-0.0063594

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.35139175
2Vitamin B6 metabolism_Homo sapiens_hsa007504.25876882
3Fatty acid biosynthesis_Homo sapiens_hsa000613.91002009
4Pyruvate metabolism_Homo sapiens_hsa006203.89700721
5Ribosome_Homo sapiens_hsa030103.59362125
6Mismatch repair_Homo sapiens_hsa034303.34318834
7Base excision repair_Homo sapiens_hsa034103.22867926
8Propanoate metabolism_Homo sapiens_hsa006403.04400173
9Proteasome_Homo sapiens_hsa030502.96603758
10Homologous recombination_Homo sapiens_hsa034402.93666689
11Glucagon signaling pathway_Homo sapiens_hsa049222.88929841
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87528924
13One carbon pool by folate_Homo sapiens_hsa006702.82143026
14Linoleic acid metabolism_Homo sapiens_hsa005912.79234071
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69648250
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.65610052
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.57858055
18Selenocompound metabolism_Homo sapiens_hsa004502.45511670
19Spliceosome_Homo sapiens_hsa030402.38077320
20Nucleotide excision repair_Homo sapiens_hsa034202.36172733
21Basal transcription factors_Homo sapiens_hsa030222.23825990
22Carbohydrate digestion and absorption_Homo sapiens_hsa049732.10624533
23Dorso-ventral axis formation_Homo sapiens_hsa043202.05276599
24Pentose phosphate pathway_Homo sapiens_hsa000301.92621712
25Glycerolipid metabolism_Homo sapiens_hsa005611.90904852
26Amphetamine addiction_Homo sapiens_hsa050311.90040934
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89997879
28RNA polymerase_Homo sapiens_hsa030201.87105255
29Cell cycle_Homo sapiens_hsa041101.85727083
30Non-homologous end-joining_Homo sapiens_hsa034501.84108571
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84007376
32Oocyte meiosis_Homo sapiens_hsa041141.83278942
33Fanconi anemia pathway_Homo sapiens_hsa034601.83159326
34PPAR signaling pathway_Homo sapiens_hsa033201.80827947
35Fructose and mannose metabolism_Homo sapiens_hsa000511.80424098
36Parkinsons disease_Homo sapiens_hsa050121.74838895
37Oxidative phosphorylation_Homo sapiens_hsa001901.63181166
38Huntingtons disease_Homo sapiens_hsa050161.62429266
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.46209824
40Cardiac muscle contraction_Homo sapiens_hsa042601.45378540
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43579191
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38658227
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.35959506
44Fat digestion and absorption_Homo sapiens_hsa049751.34649750
45Carbon metabolism_Homo sapiens_hsa012001.34153253
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.33657066
47Renin secretion_Homo sapiens_hsa049241.29207868
48Ether lipid metabolism_Homo sapiens_hsa005651.26664606
49Fatty acid metabolism_Homo sapiens_hsa012121.23038334
50Sulfur relay system_Homo sapiens_hsa041221.22973305
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22020868
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19945146
53Fatty acid elongation_Homo sapiens_hsa000621.18756964
54Fatty acid degradation_Homo sapiens_hsa000711.17495521
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15505642
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15109627
57Other glycan degradation_Homo sapiens_hsa005111.12568744
58Asthma_Homo sapiens_hsa053101.11210850
59Mineral absorption_Homo sapiens_hsa049781.09390053
60Long-term potentiation_Homo sapiens_hsa047201.05432731
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04089714
62mRNA surveillance pathway_Homo sapiens_hsa030151.04057839
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99903581
64Primary immunodeficiency_Homo sapiens_hsa053400.99833965
65Antigen processing and presentation_Homo sapiens_hsa046120.96582082
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95900344
67Purine metabolism_Homo sapiens_hsa002300.94752323
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93428865
69Glutathione metabolism_Homo sapiens_hsa004800.93408409
70RNA transport_Homo sapiens_hsa030130.92284607
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85693965
72Biosynthesis of amino acids_Homo sapiens_hsa012300.82681159
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82426558
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81660473
75Collecting duct acid secretion_Homo sapiens_hsa049660.78624111
76Folate biosynthesis_Homo sapiens_hsa007900.77248651
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73716430
78Arachidonic acid metabolism_Homo sapiens_hsa005900.72458522
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.72392167
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72178658
81ABC transporters_Homo sapiens_hsa020100.71158755
82Estrogen signaling pathway_Homo sapiens_hsa049150.69907606
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.69323446
84Arginine biosynthesis_Homo sapiens_hsa002200.68462692
85Galactose metabolism_Homo sapiens_hsa000520.67518138
86Chemical carcinogenesis_Homo sapiens_hsa052040.66848690
87Acute myeloid leukemia_Homo sapiens_hsa052210.66639166
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66285569
89Calcium signaling pathway_Homo sapiens_hsa040200.65075361
90Herpes simplex infection_Homo sapiens_hsa051680.64376869
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63641797
92Systemic lupus erythematosus_Homo sapiens_hsa053220.63477779
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62964018
94Allograft rejection_Homo sapiens_hsa053300.62326905
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.62204820
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61728903
97Epstein-Barr virus infection_Homo sapiens_hsa051690.60972258
98Hedgehog signaling pathway_Homo sapiens_hsa043400.60419370
99Autoimmune thyroid disease_Homo sapiens_hsa053200.60375981
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.54864130
101Peroxisome_Homo sapiens_hsa041460.53665345
102Insulin secretion_Homo sapiens_hsa049110.53553588
103Thyroid hormone synthesis_Homo sapiens_hsa049180.50856900
104VEGF signaling pathway_Homo sapiens_hsa043700.50555188
105AMPK signaling pathway_Homo sapiens_hsa041520.49800159
106Viral carcinogenesis_Homo sapiens_hsa052030.48501817
107Legionellosis_Homo sapiens_hsa051340.46978421
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45304179
109Nitrogen metabolism_Homo sapiens_hsa009100.45122161
110Synaptic vesicle cycle_Homo sapiens_hsa047210.44844670
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43794494
112Graft-versus-host disease_Homo sapiens_hsa053320.43600856
113Bile secretion_Homo sapiens_hsa049760.43144552
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43002964
115Endocytosis_Homo sapiens_hsa041440.42075760
116p53 signaling pathway_Homo sapiens_hsa041150.40699391
117Protein export_Homo sapiens_hsa030600.39575958
118Renin-angiotensin system_Homo sapiens_hsa046140.39078171
119Chronic myeloid leukemia_Homo sapiens_hsa052200.38620866
120HTLV-I infection_Homo sapiens_hsa051660.38589636
121Alcoholism_Homo sapiens_hsa050340.36286483
122Metabolic pathways_Homo sapiens_hsa011000.35079841
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.33708205
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33621543
125Type I diabetes mellitus_Homo sapiens_hsa049400.33527369
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31887803
127Circadian entrainment_Homo sapiens_hsa047130.31420496
128Cocaine addiction_Homo sapiens_hsa050300.30998408
129Salivary secretion_Homo sapiens_hsa049700.30709942
130Influenza A_Homo sapiens_hsa051640.30652439
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29430069
132Sulfur metabolism_Homo sapiens_hsa009200.28599306
133Leishmaniasis_Homo sapiens_hsa051400.28234194
134Tyrosine metabolism_Homo sapiens_hsa003500.28118327
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27519157
136Pancreatic secretion_Homo sapiens_hsa049720.27236886
137DNA replication_Homo sapiens_hsa030300.26555517
138Non-small cell lung cancer_Homo sapiens_hsa052230.26354109
139Glutamatergic synapse_Homo sapiens_hsa047240.26195725
140Pyrimidine metabolism_Homo sapiens_hsa002400.26000455
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25939031
142Gastric acid secretion_Homo sapiens_hsa049710.25154560
143Hematopoietic cell lineage_Homo sapiens_hsa046400.24760777
144Shigellosis_Homo sapiens_hsa051310.24404905
145cAMP signaling pathway_Homo sapiens_hsa040240.24380210
146Bladder cancer_Homo sapiens_hsa052190.24303148
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24067878
148N-Glycan biosynthesis_Homo sapiens_hsa005100.21810908
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21541158
150Apoptosis_Homo sapiens_hsa042100.21304189
151Olfactory transduction_Homo sapiens_hsa047400.20810256
152Phenylalanine metabolism_Homo sapiens_hsa003600.20396989
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20364330
154B cell receptor signaling pathway_Homo sapiens_hsa046620.20263498
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19742703
156Protein digestion and absorption_Homo sapiens_hsa049740.18996570
157Taste transduction_Homo sapiens_hsa047420.18840926
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18437436
159Salmonella infection_Homo sapiens_hsa051320.15236325
160Alzheimers disease_Homo sapiens_hsa050100.14290963
161RNA degradation_Homo sapiens_hsa030180.14120238

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »