PRSS22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.04340217
2mesodermal cell differentiation (GO:0048333)6.92451080
3interferon-gamma secretion (GO:0072643)5.65792062
4cell adhesion mediated by integrin (GO:0033627)5.45038606
5detection of bacterium (GO:0016045)5.40725185
6diterpenoid biosynthetic process (GO:0016102)5.39885335
7hepatocyte differentiation (GO:0070365)5.32334239
8glial cell proliferation (GO:0014009)4.99664579
9detection of other organism (GO:0098543)4.90580570
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.86595655
11water homeostasis (GO:0030104)4.86008206
12desmosome organization (GO:0002934)4.83627260
13hypotonic response (GO:0006971)4.82119356
14positive regulation of cellular amide metabolic process (GO:0034250)4.75050982
15hepatocyte apoptotic process (GO:0097284)4.71726192
16skin morphogenesis (GO:0043589)4.69020753
17epithelial cell-cell adhesion (GO:0090136)4.59941875
18positive regulation of osteoblast proliferation (GO:0033690)4.50673597
19positive regulation of Cdc42 GTPase activity (GO:0043089)4.49667677
20COPI coating of Golgi vesicle (GO:0048205)4.49646198
21Golgi transport vesicle coating (GO:0048200)4.49646198
22lung epithelium development (GO:0060428)4.34427168
23terpenoid biosynthetic process (GO:0016114)4.29926244
24regulation of transmission of nerve impulse (GO:0051969)4.29724773
25kidney morphogenesis (GO:0060993)4.24024311
26keratinocyte proliferation (GO:0043616)4.22870074
27regulation of alkaline phosphatase activity (GO:0010692)4.20884749
28renal filtration (GO:0097205)4.14621617
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99790700
30keratinocyte differentiation (GO:0030216)3.95877426
31substrate-dependent cell migration (GO:0006929)3.94748482
32citrulline biosynthetic process (GO:0019240)3.91001559
33ear development (GO:0043583)3.85553464
34regulation of water loss via skin (GO:0033561)3.79645746
35establishment of apical/basal cell polarity (GO:0035089)3.77969250
36branching involved in mammary gland duct morphogenesis (GO:0060444)3.76442230
37regulation of ruffle assembly (GO:1900027)3.74737248
38peptide cross-linking (GO:0018149)3.69135501
39positive regulation of epidermal cell differentiation (GO:0045606)3.66636172
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.63973031
41semaphorin-plexin signaling pathway (GO:0071526)3.63711315
42keratinization (GO:0031424)3.61626398
43negative regulation of cell fate specification (GO:0009996)3.60922482
44cell differentiation involved in embryonic placenta development (GO:0060706)3.60793315
45negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.55424601
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.53564880
47amyloid precursor protein metabolic process (GO:0042982)3.52227633
48positive regulation of keratinocyte differentiation (GO:0045618)3.49044146
49positive regulation of neurological system process (GO:0031646)3.47718914
50surfactant homeostasis (GO:0043129)3.41478171
51axonemal dynein complex assembly (GO:0070286)3.41104730
52epidermis development (GO:0008544)3.39303797
53respiratory tube development (GO:0030323)3.37536790
54cell-substrate junction assembly (GO:0007044)3.33751074
55positive regulation of epidermis development (GO:0045684)3.33695871
56atrioventricular valve morphogenesis (GO:0003181)3.31288084
57negative regulation of keratinocyte proliferation (GO:0010839)3.30906063
58endothelial cell chemotaxis (GO:0035767)3.30452751
59gap junction assembly (GO:0016264)3.29096496
60ectoderm development (GO:0007398)3.28790409
61limb bud formation (GO:0060174)3.28598591
62establishment of skin barrier (GO:0061436)3.28249491
63regulation of interleukin-8 secretion (GO:2000482)3.27747929
64positive regulation of actin filament depolymerization (GO:0030836)3.25847025
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22682578
66regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.20684510
67lung-associated mesenchyme development (GO:0060484)3.20466412
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.19987918
69neural crest cell development (GO:0014032)3.17635653
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.17147724
71face development (GO:0060324)3.17109148
72protein retention in ER lumen (GO:0006621)3.16289984
73primary alcohol catabolic process (GO:0034310)3.14844496
74L-serine transport (GO:0015825)3.14767717
75positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.14315147
76calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.13633525
77regulation of chemokine secretion (GO:0090196)3.13605327
78regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.13518183
79regulation of cell proliferation involved in kidney development (GO:1901722)3.11938515
80asymmetric protein localization (GO:0008105)3.11539361
81regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.11472170
82establishment of planar polarity (GO:0001736)3.10437805
83establishment of tissue polarity (GO:0007164)3.10437805
84citrulline metabolic process (GO:0000052)3.09560478
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05472260
86wound healing, spreading of epidermal cells (GO:0035313)3.04525923
87cell-substrate adherens junction assembly (GO:0007045)3.04082766
88focal adhesion assembly (GO:0048041)3.04082766
89regulation of keratinocyte differentiation (GO:0045616)3.03888254
90regulation of interleukin-13 production (GO:0032656)3.03809611
91cell-cell junction maintenance (GO:0045217)3.01939691
92lens fiber cell development (GO:0070307)3.00480593
93epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99828241
94positive regulation of protein localization to plasma membrane (GO:1903078)2.99606933
95positive regulation of positive chemotaxis (GO:0050927)2.95158117
96regulation of cardioblast differentiation (GO:0051890)2.95154664
97cell-cell junction assembly (GO:0007043)2.94798731
98apical protein localization (GO:0045176)2.93437927
99establishment or maintenance of monopolar cell polarity (GO:0061339)2.91608385
100establishment of monopolar cell polarity (GO:0061162)2.91608385
101regulation of cell fate specification (GO:0042659)2.90582622
102molting cycle (GO:0042303)2.90145270
103hair cycle (GO:0042633)2.90145270
104negative regulation of cell size (GO:0045792)2.87645643
105adherens junction assembly (GO:0034333)2.86918566
106keratinocyte development (GO:0003334)2.86039115
107regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85506023
108negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.84166787
109regulation of positive chemotaxis (GO:0050926)2.83895915
110mammary gland epithelial cell differentiation (GO:0060644)2.82102423
111positive regulation of interleukin-8 secretion (GO:2000484)2.81827163
112wound healing, spreading of cells (GO:0044319)2.81757938
113maintenance of gastrointestinal epithelium (GO:0030277)2.81047371
114serine transport (GO:0032329)2.79147680
115positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.77444389
116epidermal cell differentiation (GO:0009913)2.76917483
117mammary gland epithelial cell proliferation (GO:0033598)2.75885515
118polarized epithelial cell differentiation (GO:0030859)2.74924700
119detection of external biotic stimulus (GO:0098581)2.74334908
120tight junction assembly (GO:0070830)2.73598251
121branching involved in salivary gland morphogenesis (GO:0060445)2.73529613
122regulation of cholesterol homeostasis (GO:2000188)2.72813802
123endodermal cell differentiation (GO:0035987)2.72565522
124regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.72312523
125regulation of Cdc42 GTPase activity (GO:0043088)2.71975394
126regulation of glomerular filtration (GO:0003093)2.71111448
127positive regulation of monocyte chemotaxis (GO:0090026)2.71108016
128multicellular organismal water homeostasis (GO:0050891)2.70739029
129vitamin transmembrane transport (GO:0035461)2.70292793
130chemical homeostasis within a tissue (GO:0048875)2.69971328
131regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.69701704
132endothelial cell morphogenesis (GO:0001886)2.69639402
133cell junction maintenance (GO:0034331)2.69623553
134O-glycan processing (GO:0016266)2.69488429
135phospholipid scrambling (GO:0017121)2.69444957
136establishment of protein localization to plasma membrane (GO:0090002)2.69241978
137positive regulation of toll-like receptor signaling pathway (GO:0034123)2.68439919
138amyloid precursor protein catabolic process (GO:0042987)2.67783075
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.67640442
140regulation of osteoblast proliferation (GO:0033688)2.66945705
141response to muscle activity (GO:0014850)2.66249187
142microglial cell activation (GO:0001774)2.66214341
143morphogenesis of embryonic epithelium (GO:0016331)2.65302158
144maternal placenta development (GO:0001893)2.63992164
145organ formation (GO:0048645)2.62470443
146cartilage morphogenesis (GO:0060536)2.61298174
147lung lobe morphogenesis (GO:0060463)2.60705836
148eye photoreceptor cell differentiation (GO:0001754)2.60024904
149photoreceptor cell differentiation (GO:0046530)2.60024904
150regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.59220420
151lung vasculature development (GO:0060426)2.58996826
152retinal metabolic process (GO:0042574)2.58936243
153lung morphogenesis (GO:0060425)2.57947555
154activation of Rac GTPase activity (GO:0032863)2.56393639
155positive regulation of actin cytoskeleton reorganization (GO:2000251)2.56359307
156ephrin receptor signaling pathway (GO:0048013)2.56207659
157intestinal epithelial cell development (GO:0060576)2.54250157
158regulation of beta-amyloid formation (GO:1902003)2.53845216
159postsynaptic membrane organization (GO:0001941)2.53708395
160regulation of natural killer cell differentiation (GO:0032823)2.52260404
161regulation of transforming growth factor beta2 production (GO:0032909)2.51978362
162phosphatidylserine metabolic process (GO:0006658)2.51718862
163positive regulation of smooth muscle cell migration (GO:0014911)2.51498524
164negative regulation of chondrocyte differentiation (GO:0032331)2.50315287
165negative regulation of cell fate commitment (GO:0010454)2.48579234
166regulation of RIG-I signaling pathway (GO:0039535)2.47006834
167response to water (GO:0009415)2.46038142
168L-fucose metabolic process (GO:0042354)2.41988753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.17315752
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.07049771
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.68465868
4ZNF263_19887448_ChIP-Seq_K562_Human3.21571748
5RACK7_27058665_Chip-Seq_MCF-7_Human2.98777598
6* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45841826
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.41535336
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.24103557
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.20424159
10LXR_22292898_ChIP-Seq_THP-1_Human2.18539943
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.14044809
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.14044809
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.07199222
14SOX2_20726797_ChIP-Seq_SW620_Human2.03344292
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.02422939
16TP63_17297297_ChIP-ChIP_HaCaT_Human10.5142414
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.97365257
18ATF3_27146783_Chip-Seq_COLON_Human1.90377788
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84970915
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84585024
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.78042837
22TP53_18474530_ChIP-ChIP_U2OS_Human1.71867268
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.65145606
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60322114
25CJUN_26792858_Chip-Seq_BT549_Human1.59670811
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57337119
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53888095
28* SMC4_20622854_ChIP-Seq_HELA_Human1.53330870
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53050361
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51531315
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50827681
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50125818
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49152016
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49152016
35P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49067432
36GBX2_23144817_ChIP-Seq_PC3_Human1.48595183
37KLF5_25053715_ChIP-Seq_YYC3_Human1.48268879
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47813544
39CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47092335
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45020664
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44462076
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44459985
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43758597
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43564448
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42349971
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.39936412
47KDM2B_26808549_Chip-Seq_K562_Human1.39416661
48CLOCK_20551151_ChIP-Seq_293T_Human1.38464070
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37875649
50CREB1_26743006_Chip-Seq_LNCaP_Human1.37659306
51AHR_22903824_ChIP-Seq_MCF-7_Human1.36944302
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35643447
53TP63_22573176_ChIP-Seq_HFKS_Human1.35169380
54* P68_20966046_ChIP-Seq_HELA_Human1.34453346
55TCF7_22412390_ChIP-Seq_EML_Mouse1.33746377
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33725135
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.31739224
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31534318
59TP53_16413492_ChIP-PET_HCT116_Human1.31515815
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29825480
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29745326
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29438009
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.29385097
64* EP300_21415370_ChIP-Seq_HL-1_Mouse1.28725086
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27138725
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27070276
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26581918
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26215722
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.24280876
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24024014
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.23960313
72GATA4_25053715_ChIP-Seq_YYC3_Human1.23540348
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.22473789
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21807183
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21807183
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21742252
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21183846
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20222930
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.19624916
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18876557
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17238824
82* CTCF_27219007_Chip-Seq_Bcells_Human1.16988927
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16833595
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16461726
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16380645
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15722159
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.15405557
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14540762
89TAF15_26573619_Chip-Seq_HEK293_Human1.14325861
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14126342
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13453544
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12509699
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12245989
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.12123717
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10066909
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09002369
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08942852
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08489313
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08401624
100TP63_23658742_ChIP-Seq_EP156T_Human1.06450401
101CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06385917
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05857548
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05640805
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05373864
105KDM2B_26808549_Chip-Seq_DND41_Human1.05166193
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04981893
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.04757749
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04666151
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04016164
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03926342
111* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03587481
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02963781
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02101421
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01955228
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01525974
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01386868
117UBF1/2_26484160_Chip-Seq_HMECs_Human1.01279743
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.00410546
119TP53_22127205_ChIP-Seq_IMR90_Human1.00235090
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99691282
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98644301
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98174760
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97934770
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97375310
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96844932
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.96427295
127VDR_21846776_ChIP-Seq_THP-1_Human0.96242462
128ELF5_23300383_ChIP-Seq_T47D_Human0.95913709
129* BCOR_27268052_Chip-Seq_Bcells_Human0.94771911
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94501253
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94493835
132TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94038529
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93899438
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.93887574
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93622627
136GATA6_25053715_ChIP-Seq_YYC3_Human0.93173064
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93144995
138EZH2_27304074_Chip-Seq_ESCs_Mouse0.92775724
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92353452
140* RUNX1_27514584_Chip-Seq_MCF-7_Human0.91887087
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91376935
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91336123
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.89745119
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89429897
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89011312
146KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87359264
147DROSHA_22980978_ChIP-Seq_HELA_Human0.86626200
148RARB_24833708_ChIP-Seq_LIVER_Mouse0.85561951
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84471545
150AR_21572438_ChIP-Seq_LNCaP_Human0.83981102
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82716265
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77601135
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76387534
154AR_25329375_ChIP-Seq_VCAP_Human0.76305650
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76224195
156P300_19829295_ChIP-Seq_ESCs_Human0.75352878
157ERG_21242973_ChIP-ChIP_JURKAT_Human0.75055258
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74272183
159CBX2_27304074_Chip-Seq_ESCs_Mouse0.73420777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology5.90066424
2MP0010234_abnormal_vibrissa_follicle5.81809093
3MP0004272_abnormal_basement_membrane3.36282048
4MP0002796_impaired_skin_barrier3.24456270
5MP0003705_abnormal_hypodermis_morpholog3.00571965
6MP0004264_abnormal_extraembryonic_tissu2.91710434
7MP0010678_abnormal_skin_adnexa2.88600891
8MP0000566_synostosis2.73254964
9MP0001849_ear_inflammation2.69117208
10MP0003453_abnormal_keratinocyte_physiol2.57413067
11MP0002234_abnormal_pharynx_morphology2.52119453
12MP0005501_abnormal_skin_physiology2.40957811
13MP0005083_abnormal_biliary_tract2.29612755
14MP0003878_abnormal_ear_physiology2.27429775
15MP0005377_hearing/vestibular/ear_phenot2.27429775
16MP0000762_abnormal_tongue_morphology2.20010286
17MP0001216_abnormal_epidermal_layer2.19961243
18MP0005275_abnormal_skin_tensile2.15328193
19MP0002098_abnormal_vibrissa_morphology2.14091792
20MP0002060_abnormal_skin_morphology2.13310611
21MP0003941_abnormal_skin_development2.09878027
22MP0000383_abnormal_hair_follicle2.06713484
23MP0003566_abnormal_cell_adhesion2.04406622
24MP0005248_abnormal_Harderian_gland2.03392817
25MP0000678_abnormal_parathyroid_gland1.99115281
26MP0002254_reproductive_system_inflammat1.96618280
27MP0005076_abnormal_cell_differentiation1.94083119
28MP0000538_abnormal_urinary_bladder1.86345250
29MP0003329_amyloid_beta_deposits1.81580978
30MP0010771_integument_phenotype1.80355133
31MP0000579_abnormal_nail_morphology1.72991007
32MP0003191_abnormal_cellular_cholesterol1.71001985
33MP0000462_abnormal_digestive_system1.66614908
34MP0009785_altered_susceptibility_to1.61680745
35MP0004185_abnormal_adipocyte_glucose1.57189804
36MP0000627_abnormal_mammary_gland1.57165035
37MP0000858_altered_metastatic_potential1.54479426
38MP0004858_abnormal_nervous_system1.51760179
39MP0005023_abnormal_wound_healing1.50646320
40MP0002277_abnormal_respiratory_mucosa1.44487991
41MP0004947_skin_inflammation1.44056369
42MP0003115_abnormal_respiratory_system1.43712610
43MP0000467_abnormal_esophagus_morphology1.42924252
44MP0005409_darkened_coat_color1.42433278
45MP0001664_abnormal_digestion1.40160324
46MP0001346_abnormal_lacrimal_gland1.40015236
47MP0004782_abnormal_surfactant_physiolog1.36258662
48MP0008875_abnormal_xenobiotic_pharmacok1.35654254
49MP0010155_abnormal_intestine_physiology1.34783755
50MP0003937_abnormal_limbs/digits/tail_de1.27866222
51MP0003866_abnormal_defecation1.27200717
52MP0002877_abnormal_melanocyte_morpholog1.24645049
53MP0001881_abnormal_mammary_gland1.19130102
54MP0002249_abnormal_larynx_morphology1.17056130
55MP0005166_decreased_susceptibility_to1.16362478
56MP0002233_abnormal_nose_morphology1.11725674
57MP0004019_abnormal_vitamin_homeostasis1.11142242
58MP0004043_abnormal_pH_regulation1.10268234
59MP0002876_abnormal_thyroid_physiology1.09862334
60MP0002138_abnormal_hepatobiliary_system1.09736308
61MP0003119_abnormal_digestive_system1.08790550
62MP0005058_abnormal_lysosome_morphology1.07750281
63MP0004381_abnormal_hair_follicle1.07058475
64MP0000377_abnormal_hair_follicle1.05905977
65MP0005257_abnormal_intraocular_pressure1.03318781
66MP0000367_abnormal_coat/_hair1.02625595
67MP0003936_abnormal_reproductive_system1.02474536
68MP0000343_altered_response_to1.02026031
69MP0009780_abnormal_chondrocyte_physiolo1.01472771
70MP0005367_renal/urinary_system_phenotyp1.01387523
71MP0000516_abnormal_urinary_system1.01387523
72MP0000427_abnormal_hair_cycle1.00426724
73MP0005167_abnormal_blood-brain_barrier0.99758429
74MP0000003_abnormal_adipose_tissue0.96338807
75MP0000647_abnormal_sebaceous_gland0.96166478
76MP0002282_abnormal_trachea_morphology0.95943736
77MP0001191_abnormal_skin_condition0.95908776
78MP0005164_abnormal_response_to0.95695496
79MP0000470_abnormal_stomach_morphology0.94423720
80MP0001765_abnormal_ion_homeostasis0.93939723
81MP0002295_abnormal_pulmonary_circulatio0.90364943
82MP0004133_heterotaxia0.89923045
83MP0003890_abnormal_embryonic-extraembry0.89351826
84MP0009764_decreased_sensitivity_to0.88131868
85MP0009840_abnormal_foam_cell0.88066934
86MP0000477_abnormal_intestine_morphology0.87925137
87MP0003075_altered_response_to0.87052182
88MP0009931_abnormal_skin_appearance0.86750309
89MP0001853_heart_inflammation0.86523444
90MP0003436_decreased_susceptibility_to0.84801165
91MP0001873_stomach_inflammation0.84469697
92MP0010368_abnormal_lymphatic_system0.84363748
93MP0001243_abnormal_dermal_layer0.83204502
94MP0005666_abnormal_adipose_tissue0.82825590
95MP0000049_abnormal_middle_ear0.82808708
96MP0002909_abnormal_adrenal_gland0.82647972
97MP0005451_abnormal_body_composition0.81321523
98MP0008004_abnormal_stomach_pH0.80512680
99MP0009384_cardiac_valve_regurgitation0.79586204
100MP0008789_abnormal_olfactory_epithelium0.79523502
101MP0003755_abnormal_palate_morphology0.79335584
102MP0003632_abnormal_nervous_system0.79206616
103MP0003300_gastrointestinal_ulcer0.78654731
104MP0005375_adipose_tissue_phenotype0.78631104
105MP0000432_abnormal_head_morphology0.78360979
106MP0001533_abnormal_skeleton_physiology0.78288676
107MP0002177_abnormal_outer_ear0.77442879
108MP0001340_abnormal_eyelid_morphology0.77274787
109MP0006054_spinal_hemorrhage0.75960003
110MP0001286_abnormal_eye_development0.75767558
111MP0003638_abnormal_response/metabolism_0.75468198
112MP0003091_abnormal_cell_migration0.75286873
113MP0009053_abnormal_anal_canal0.75056978
114MP0001501_abnormal_sleep_pattern0.74696463
115MP0004742_abnormal_vestibular_system0.74401522
116MP0005381_digestive/alimentary_phenotyp0.74263844
117MP0008260_abnormal_autophagy0.73430265
118MP0002089_abnormal_postnatal_growth/wei0.73047935
119MP0003045_fibrosis0.73011673
120MP0003315_abnormal_perineum_morphology0.72537038
121MP0000163_abnormal_cartilage_morphology0.72224197
122MP0001666_abnormal_nutrient_absorption0.71311493
123MP0005670_abnormal_white_adipose0.71109285
124MP0010030_abnormal_orbit_morphology0.70985231
125MP0000534_abnormal_ureter_morphology0.70136525
126MP0001879_abnormal_lymphatic_vessel0.67067492
127MP0003828_pulmonary_edema0.66242091
128MP0010352_gastrointestinal_tract_polyps0.66110954
129MP0000604_amyloidosis0.65990837
130MP0002735_abnormal_chemical_nociception0.65665581
131MP0002896_abnormal_bone_mineralization0.65510169
132MP0000013_abnormal_adipose_tissue0.65087633
133MP0009643_abnormal_urine_homeostasis0.64977663
134MP0005165_increased_susceptibility_to0.64144065
135MP0005394_taste/olfaction_phenotype0.63558097
136MP0003123_paternal_imprinting0.59225528
137MP0001727_abnormal_embryo_implantation0.57518570
138MP0000613_abnormal_salivary_gland0.56576420
139MP0002111_abnormal_tail_morphology0.52648228
140MP0001348_abnormal_lacrimal_gland0.51987761
141MP0005508_abnormal_skeleton_morphology0.49235584
142MP0002136_abnormal_kidney_physiology0.46721218
143MP0000681_abnormal_thyroid_gland0.44767908
144MP0002653_abnormal_ependyma_morphology0.44686942
145MP0001851_eye_inflammation0.42127731
146MP0003942_abnormal_urinary_system0.41791912
147MP0002086_abnormal_extraembryonic_tissu0.41228834
148MP0000733_abnormal_muscle_development0.40752794

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)7.99004994
2Fragile nails (HP:0001808)7.75788398
3Atrophic scars (HP:0001075)7.37275258
4Plantar hyperkeratosis (HP:0007556)5.69435896
5Abnormality of nail color (HP:0100643)5.65274763
6Right ventricular cardiomyopathy (HP:0011663)5.03807702
7Pustule (HP:0200039)5.02216268
8Nail dystrophy (HP:0008404)4.86325578
9Interstitial pulmonary disease (HP:0006530)4.36064314
10Micronodular cirrhosis (HP:0001413)4.32151114
11Hypoplasia of dental enamel (HP:0006297)4.25106459
12Parakeratosis (HP:0001036)3.98938890
13Lip pit (HP:0100267)3.83370403
14Fragile skin (HP:0001030)3.64545360
15Alopecia of scalp (HP:0002293)3.60305409
16Distal lower limb muscle weakness (HP:0009053)3.57893328
17Abnormal blistering of the skin (HP:0008066)3.55798706
18Chronic bronchitis (HP:0004469)3.45032421
19Pili torti (HP:0003777)3.40908268
20Abnormality of the distal phalanges of the toes (HP:0010182)3.39628550
21Hyperactive renin-angiotensin system (HP:0000841)3.33684906
22Aplasia cutis congenita (HP:0001057)3.29790112
23Arterial tortuosity (HP:0005116)3.24026868
24Abnormality of the nasal septum (HP:0000419)3.22418171
25Focal segmental glomerulosclerosis (HP:0000097)3.19557484
26Distal lower limb amyotrophy (HP:0008944)3.18102439
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14544575
28Curly hair (HP:0002212)3.07197510
29Oral leukoplakia (HP:0002745)3.00671863
30Congenital ichthyosiform erythroderma (HP:0007431)2.94617068
31Esophageal atresia (HP:0002032)2.89809778
32Fibular aplasia (HP:0002990)2.89733555
33Vascular tortuosity (HP:0004948)2.84732212
34Glomerulosclerosis (HP:0000096)2.84687457
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83653529
36Bronchomalacia (HP:0002780)2.79773247
37Erythema (HP:0010783)2.77042857
38Acanthosis nigricans (HP:0000956)2.75356874
39Nasal polyposis (HP:0100582)2.72450689
40Cervical subluxation (HP:0003308)2.72021256
41Amelogenesis imperfecta (HP:0000705)2.70916910
42Axonal loss (HP:0003447)2.69426309
43Woolly hair (HP:0002224)2.68563653
44Vascular calcification (HP:0004934)2.66547327
45Pterygium (HP:0001059)2.66463577
46Cheilitis (HP:0100825)2.65723500
47Popliteal pterygium (HP:0009756)2.64625720
48Cone-rod dystrophy (HP:0000548)2.63164861
49Abnormal respiratory epithelium morphology (HP:0012253)2.59723597
50Abnormal respiratory motile cilium morphology (HP:0005938)2.59723597
51Abnormality of the salivary glands (HP:0010286)2.59178095
52Upper limb amyotrophy (HP:0009129)2.56914910
53Distal upper limb amyotrophy (HP:0007149)2.56914910
54Septate vagina (HP:0001153)2.56844194
55Humeroradial synostosis (HP:0003041)2.55846531
56Synostosis involving the elbow (HP:0003938)2.55846531
57Advanced eruption of teeth (HP:0006288)2.51629705
58Abnormality of the gastric mucosa (HP:0004295)2.51166520
59Palmoplantar hyperkeratosis (HP:0000972)2.50527421
60Hypotrichosis (HP:0001006)2.50283691
61Trismus (HP:0000211)2.48470770
62Choroideremia (HP:0001139)2.48329080
63Increased IgE level (HP:0003212)2.45351887
64Hypodontia (HP:0000668)2.45194770
65Abnormality of proline metabolism (HP:0010907)2.41524156
66Hydroxyprolinuria (HP:0003080)2.41524156
67Abnormal respiratory motile cilium physiology (HP:0012261)2.39602795
68Sparse eyelashes (HP:0000653)2.39093219
69Aplasia/hypoplasia of the uterus (HP:0008684)2.39076260
70Renal salt wasting (HP:0000127)2.37016391
71J-shaped sella turcica (HP:0002680)2.36444506
72Cardiovascular calcification (HP:0011915)2.35463154
73Flat acetabular roof (HP:0003180)2.35160444
74Ankyloglossia (HP:0010296)2.34355635
75Palmar hyperkeratosis (HP:0010765)2.33715514
76Corneal erosion (HP:0200020)2.31910099
77Ureteral stenosis (HP:0000071)2.31590219
78Thin bony cortex (HP:0002753)2.30400139
79Mildly elevated creatine phosphokinase (HP:0008180)2.30212673
80Epiphyseal dysplasia (HP:0002656)2.29748090
81Diaphragmatic weakness (HP:0009113)2.29599803
82Stridor (HP:0010307)2.27399565
83Rhinitis (HP:0012384)2.27320219
84Xerostomia (HP:0000217)2.25559191
85Selective tooth agenesis (HP:0001592)2.22174600
86Ectropion (HP:0000656)2.21898768
87Hyperphosphatemia (HP:0002905)2.21853419
88Ureteral obstruction (HP:0006000)2.21176450
89Ridged nail (HP:0001807)2.20086234
90Abnormality of molar (HP:0011077)2.18277346
91Abnormality of molar morphology (HP:0011070)2.18277346
92Abnormality of the nasal mucosa (HP:0000433)2.17926862
93Abnormal ciliary motility (HP:0012262)2.16907951
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.15087327
95Absent/shortened dynein arms (HP:0200106)2.15087327
96Vitreoretinal degeneration (HP:0000655)2.11432587
97Hyperacusis (HP:0010780)2.10395660
98Central scotoma (HP:0000603)2.09730908
99Erythroderma (HP:0001019)2.06199873
100Absent eyelashes (HP:0000561)2.03207132
101Hypoplasia of the uterus (HP:0000013)2.01560937
102Subacute progressive viral hepatitis (HP:0006572)2.01063962
103Onycholysis (HP:0001806)10.8556940
104Dehydration (HP:0001944)1.99964290
105Abnormality of macular pigmentation (HP:0008002)1.95751748
106Palmoplantar keratoderma (HP:0000982)1.95180122
107Decreased central vision (HP:0007663)1.93541176
108Hoarse voice (HP:0001609)1.90680779
109Mixed hearing impairment (HP:0000410)1.90418647
110Obstructive sleep apnea (HP:0002870)1.88170116
111Conical tooth (HP:0000698)1.88131086
112Barrel-shaped chest (HP:0001552)1.88037366
113Bronchiectasis (HP:0002110)1.87947304
114Abnormal pancreas size (HP:0012094)1.87931419
115Hypoplastic labia majora (HP:0000059)1.87104821
116Split foot (HP:0001839)1.86106872
117Natal tooth (HP:0000695)1.85452737
118Lower limb amyotrophy (HP:0007210)1.85427002
119Thick nail (HP:0001805)1.82788238
120Atelectasis (HP:0100750)1.82551004
121Premature loss of primary teeth (HP:0006323)1.81119377
122Broad face (HP:0000283)1.80984191
123Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.80080444
124Aplasia involving bones of the extremities (HP:0009825)1.79480420
125Aplasia involving bones of the upper limbs (HP:0009823)1.79480420
126Aplasia of the phalanges of the hand (HP:0009802)1.79480420
127Malnutrition (HP:0004395)1.79016498
128Dyschromatopsia (HP:0007641)1.78959235
129Hyperkalemia (HP:0002153)1.77285507
130Hypohidrosis (HP:0000966)1.76698382
131Oligodontia (HP:0000677)1.75158054
132Abnormal hair laboratory examination (HP:0003328)1.74683899
133Abnormality of the neuromuscular junction (HP:0003398)1.73459918
134Fatigable weakness (HP:0003473)1.73459918
135Abnormality of the dental pulp (HP:0006479)1.72295371
136Anhidrosis (HP:0000970)1.71070554
137Esophageal varix (HP:0002040)1.70224633
138Short nail (HP:0001799)1.69617991
139Spinal cord compression (HP:0002176)1.69062934
140Gastrointestinal atresia (HP:0002589)1.68766700
141Weak cry (HP:0001612)1.68484440
142Ventricular tachycardia (HP:0004756)1.67482575
143Scanning speech (HP:0002168)1.66091466
144Progressive sensorineural hearing impairment (HP:0000408)1.65945675
145Absent eyebrow (HP:0002223)1.65613629
146Abdominal distention (HP:0003270)1.65032432
147Abnormality of carpal bone ossification (HP:0006257)1.64903093
14811 pairs of ribs (HP:0000878)1.63868421
149Abnormality of the dental root (HP:0006486)1.63021971
150Taurodontia (HP:0000679)1.63021971
151Abnormality of permanent molar morphology (HP:0011071)1.63021971
152Abnormality of placental membranes (HP:0011409)1.62196254
153Amniotic constriction ring (HP:0009775)1.62196254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.40580707
2TRIB33.71610371
3MAP3K123.65069194
4SIK13.45005014
5MST1R2.93969326
6FER2.53799220
7EPHB22.32358547
8EPHA211.8666434
9ERBB31.91770612
10LMTK21.87428141
11PTK21.85084963
12PKN21.79445690
13IRAK31.78800905
14MAPKAPK31.69517867
15CDK81.66119728
16SMG11.64465885
17PAK41.57704123
18RPS6KB21.43468677
19TRPM71.42774204
20BCR1.41669473
21BMPR1B1.40581322
22NME21.36333140
23NME11.34696490
24MET1.34358905
25MAP2K21.33222466
26PIM21.26523058
27CASK1.22883025
28MAP3K141.20534889
29MUSK1.13133177
30PIK3CA1.07532368
31FRK1.07420417
32MAP2K10.99724413
33TESK10.96245663
34MAP3K20.95968142
35STK100.92624508
36ICK0.91941149
37MAP3K60.90253840
38RIPK40.89705713
39MAP3K30.87980499
40TAOK10.87853134
41TGFBR20.86855797
42EPHA40.86693862
43SIK30.85126619
44LATS10.84935169
45EPHB10.83733037
46PRKCE0.82887773
47PAK30.82273042
48STK380.81946452
49MYLK0.81201213
50CDK190.80543001
51PTK60.80474782
52MAP3K90.78439613
53ERBB40.78005643
54PDGFRA0.73181292
55NEK60.73111861
56MTOR0.72402467
57CAMK2B0.71135891
58ROCK20.68776487
59CDK120.68487830
60FGR0.64894474
61PRKCI0.62023593
62PLK20.61699074
63ILK0.60937534
64CHUK0.60595700
65PRKG20.60173144
66LIMK10.59783168
67MARK20.59507985
68MAP3K130.58790351
69TGFBR10.58513589
70LRRK20.57588425
71CAMK2D0.55802092
72BMX0.52640185
73NEK90.51748360
74PRKD20.51189033
75ZAP700.50829691
76CDC42BPA0.50363146
77SCYL20.49922121
78CDK70.48966223
79RPS6KA20.48953416
80MAP3K70.48780456
81IRAK20.48233401
82CDK90.48028260
83CAMK2G0.47912917
84LATS20.47662504
85DYRK1B0.47629826
86FGFR40.46997694
87TESK20.46862125
88STK390.46274767
89ERN10.45816570
90PDGFRB0.45541075
91HIPK20.44308520
92SRC0.43167615
93CAMK2A0.43097672
94NUAK10.42614600
95DAPK30.41350451
96EEF2K0.41112814
97PTK2B0.40739313
98FGFR10.39537670
99GRK60.39339997
100MAPKAPK20.37538627
101ROCK10.37158701
102ARAF0.36249174
103OXSR10.34636794
104PDPK10.33241339
105YES10.32250447
106EGFR0.32234565
107MAP2K60.31755767
108ADRBK10.31526757
109STK240.31211925
110DAPK10.31094734
111DMPK0.30645504
112SGK10.30226760
113INSR0.29838049
114RET0.29633907
115ABL10.28839575
116PBK0.28053598
117STK30.27373046
118BLK0.27178530
119NTRK10.26956281
120TNIK0.26648595
121CSK0.26525945
122IRAK10.25758245
123EIF2AK10.24091580
124DDR20.23797021
125RPS6KC10.23443805
126RPS6KL10.23443805
127CDK60.22934694
128CSNK1A1L0.22577633
129ABL20.22198092
130IGF1R0.21238522
131CSNK1G30.20630792
132CSNK1G20.20241474
133ERBB20.20037824
134TBK10.19696766
135RPS6KA40.19492109
136FYN0.19213160
137RIPK10.18613018
138PRKCA0.18570244
139PRKCD0.18045031
140MAP3K10.17467938
141ADRBK20.17327927
142MAPK150.17167050
143STK38L0.17000448
144PRKD10.16275195
145MAP3K110.15979250
146TAOK20.14995269
147MAPK80.14641900

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.18246060
2Phenylalanine metabolism_Homo sapiens_hsa003602.88170792
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.84976792
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.66396034
5Small cell lung cancer_Homo sapiens_hsa052222.51265944
6Other glycan degradation_Homo sapiens_hsa005112.51045122
7Hematopoietic cell lineage_Homo sapiens_hsa046402.30748358
8Adherens junction_Homo sapiens_hsa045202.28075411
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.26651407
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19756693
11Notch signaling pathway_Homo sapiens_hsa043302.18903226
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00719678
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00243428
14Tight junction_Homo sapiens_hsa045301.96196883
15Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.91620338
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.91478686
17Fructose and mannose metabolism_Homo sapiens_hsa000511.87132916
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.83090053
19Histidine metabolism_Homo sapiens_hsa003401.76115683
20Galactose metabolism_Homo sapiens_hsa000521.75296930
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.73817672
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68165449
23Rheumatoid arthritis_Homo sapiens_hsa053231.65692928
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62982498
25Proteoglycans in cancer_Homo sapiens_hsa052051.58693167
26Salmonella infection_Homo sapiens_hsa051321.58640177
27Malaria_Homo sapiens_hsa051441.58258231
28Focal adhesion_Homo sapiens_hsa045101.56447540
29Amoebiasis_Homo sapiens_hsa051461.54917843
30Bladder cancer_Homo sapiens_hsa052191.52045856
31Hippo signaling pathway_Homo sapiens_hsa043901.51746802
32Tyrosine metabolism_Homo sapiens_hsa003501.50757898
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49870339
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48002361
35TNF signaling pathway_Homo sapiens_hsa046681.45190239
36Shigellosis_Homo sapiens_hsa051311.44726089
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.43594607
38VEGF signaling pathway_Homo sapiens_hsa043701.39539512
39Axon guidance_Homo sapiens_hsa043601.38073333
40Toxoplasmosis_Homo sapiens_hsa051451.37999590
41Pertussis_Homo sapiens_hsa051331.34183590
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33742045
43Dilated cardiomyopathy_Homo sapiens_hsa054141.32258763
44Basal cell carcinoma_Homo sapiens_hsa052171.31563384
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.26923676
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24659406
47Nicotine addiction_Homo sapiens_hsa050331.23367853
48African trypanosomiasis_Homo sapiens_hsa051431.22215854
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22031419
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19251092
51Pentose phosphate pathway_Homo sapiens_hsa000301.19017147
52Acute myeloid leukemia_Homo sapiens_hsa052211.18965089
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16754822
54Hedgehog signaling pathway_Homo sapiens_hsa043401.15969820
55Chemical carcinogenesis_Homo sapiens_hsa052041.12519768
56Vibrio cholerae infection_Homo sapiens_hsa051101.11140166
57Sulfur relay system_Homo sapiens_hsa041221.08915431
58Insulin signaling pathway_Homo sapiens_hsa049101.05506990
59Melanoma_Homo sapiens_hsa052181.05314704
60Lysosome_Homo sapiens_hsa041421.04297301
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02735225
62Choline metabolism in cancer_Homo sapiens_hsa052311.02038912
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01553054
64Arginine biosynthesis_Homo sapiens_hsa002201.01250089
65Leishmaniasis_Homo sapiens_hsa051401.01077727
66Phagosome_Homo sapiens_hsa041451.00571219
67Salivary secretion_Homo sapiens_hsa049701.00500391
68p53 signaling pathway_Homo sapiens_hsa041150.99568701
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99215226
70Hepatitis C_Homo sapiens_hsa051600.98563399
71Wnt signaling pathway_Homo sapiens_hsa043100.97522550
72Mineral absorption_Homo sapiens_hsa049780.96294736
73Pathways in cancer_Homo sapiens_hsa052000.95400051
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92614948
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.91136124
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90895798
77ABC transporters_Homo sapiens_hsa020100.90290154
78N-Glycan biosynthesis_Homo sapiens_hsa005100.89559165
79Rap1 signaling pathway_Homo sapiens_hsa040150.89353595
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89073225
81AMPK signaling pathway_Homo sapiens_hsa041520.87552172
82Inositol phosphate metabolism_Homo sapiens_hsa005620.86419766
83Thyroid cancer_Homo sapiens_hsa052160.85908329
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84957845
85Insulin resistance_Homo sapiens_hsa049310.83691119
86Thyroid hormone synthesis_Homo sapiens_hsa049180.81627473
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80906781
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80822253
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80108217
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79609815
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79271710
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.79165461
93Sphingolipid metabolism_Homo sapiens_hsa006000.78157642
94Legionellosis_Homo sapiens_hsa051340.77463385
95TGF-beta signaling pathway_Homo sapiens_hsa043500.76497175
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75226231
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74787386
98Melanogenesis_Homo sapiens_hsa049160.74591510
99ErbB signaling pathway_Homo sapiens_hsa040120.74000084
100Estrogen signaling pathway_Homo sapiens_hsa049150.71129410
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69558916
102Endometrial cancer_Homo sapiens_hsa052130.68978402
103Pancreatic cancer_Homo sapiens_hsa052120.68553932
104mTOR signaling pathway_Homo sapiens_hsa041500.66553735
105beta-Alanine metabolism_Homo sapiens_hsa004100.66370085
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65518895
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65470461
108Ether lipid metabolism_Homo sapiens_hsa005650.65186039
109Tuberculosis_Homo sapiens_hsa051520.64915939
110Ovarian steroidogenesis_Homo sapiens_hsa049130.63730752
111Serotonergic synapse_Homo sapiens_hsa047260.63180567
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63135872
113Non-small cell lung cancer_Homo sapiens_hsa052230.61988400
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61813538
115MicroRNAs in cancer_Homo sapiens_hsa052060.61780866
116HIF-1 signaling pathway_Homo sapiens_hsa040660.60817515
117Collecting duct acid secretion_Homo sapiens_hsa049660.60572494
118Colorectal cancer_Homo sapiens_hsa052100.59610610
119GnRH signaling pathway_Homo sapiens_hsa049120.58355043
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.57144112
121Viral myocarditis_Homo sapiens_hsa054160.56762797
122Osteoclast differentiation_Homo sapiens_hsa043800.56476512
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55897479
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54951514
125Taste transduction_Homo sapiens_hsa047420.53928508
126Prolactin signaling pathway_Homo sapiens_hsa049170.53830927
127Chronic myeloid leukemia_Homo sapiens_hsa052200.53337225
128Apoptosis_Homo sapiens_hsa042100.52665439
129Ras signaling pathway_Homo sapiens_hsa040140.52554918
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.52180726
131Synaptic vesicle cycle_Homo sapiens_hsa047210.51445677
132Pancreatic secretion_Homo sapiens_hsa049720.50889283
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50302662
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49306029
135Starch and sucrose metabolism_Homo sapiens_hsa005000.48955165
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.48523446
137Renal cell carcinoma_Homo sapiens_hsa052110.48134802
138Arachidonic acid metabolism_Homo sapiens_hsa005900.47661600
139Fatty acid elongation_Homo sapiens_hsa000620.45684555
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.45271984
141Sulfur metabolism_Homo sapiens_hsa009200.45263298
142Bile secretion_Homo sapiens_hsa049760.45161039
143Endocytosis_Homo sapiens_hsa041440.44838344
144Folate biosynthesis_Homo sapiens_hsa007900.44694822
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.44346523
146Steroid biosynthesis_Homo sapiens_hsa001000.44326050
147Retinol metabolism_Homo sapiens_hsa008300.43974088
148Platelet activation_Homo sapiens_hsa046110.43664192
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42589597
150Influenza A_Homo sapiens_hsa051640.41922195
151Glutathione metabolism_Homo sapiens_hsa004800.40932393
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.38729827
153MAPK signaling pathway_Homo sapiens_hsa040100.35669886
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33658861
155Prostate cancer_Homo sapiens_hsa052150.32803717
156Glioma_Homo sapiens_hsa052140.32465282
157Gastric acid secretion_Homo sapiens_hsa049710.31129595
158GABAergic synapse_Homo sapiens_hsa047270.29894653

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