PRSS27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.33790973
2desmosome organization (GO:0002934)9.08601872
3hair cycle (GO:0042633)9.00033222
4molting cycle (GO:0042303)9.00033222
5establishment of skin barrier (GO:0061436)7.20461857
6peptide cross-linking (GO:0018149)6.75759602
7regulation of water loss via skin (GO:0033561)6.68539020
8keratinocyte differentiation (GO:0030216)6.29529178
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.84730793
10behavioral response to nicotine (GO:0035095)5.83130244
11ventricular cardiac muscle cell action potential (GO:0086005)5.58829930
12vitamin A metabolic process (GO:0006776)5.56541727
13ectoderm development (GO:0007398)5.47045054
14intermediate filament organization (GO:0045109)5.35829943
15skin morphogenesis (GO:0043589)5.28329828
16tongue development (GO:0043586)5.15244311
17regulation of heart rate by cardiac conduction (GO:0086091)5.03206697
18detection of bacterium (GO:0016045)4.99887070
19membrane repolarization during action potential (GO:0086011)4.93339702
20epidermis development (GO:0008544)4.74622169
21omega-hydroxylase P450 pathway (GO:0097267)4.69967597
22retinol metabolic process (GO:0042572)4.66138787
23L-fucose catabolic process (GO:0042355)4.62486534
24fucose catabolic process (GO:0019317)4.62486534
25L-fucose metabolic process (GO:0042354)4.62486534
26multicellular organismal water homeostasis (GO:0050891)4.56543540
27epidermal cell differentiation (GO:0009913)4.47375030
28response to pheromone (GO:0019236)4.41974707
29DNA deamination (GO:0045006)4.35926993
30detection of other organism (GO:0098543)4.35179245
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.26876151
32cardiac conduction (GO:0061337)4.16431868
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.95534435
34potassium ion import (GO:0010107)3.95317129
35potassium ion export (GO:0071435)3.94701895
36water homeostasis (GO:0030104)3.88009499
37one-carbon compound transport (GO:0019755)3.83800919
38intermediate filament cytoskeleton organization (GO:0045104)3.79280425
39transepithelial transport (GO:0070633)3.77418287
40detection of light stimulus involved in sensory perception (GO:0050962)3.74061952
41detection of light stimulus involved in visual perception (GO:0050908)3.74061952
42intermediate filament-based process (GO:0045103)3.62406925
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60798905
44cell-substrate junction assembly (GO:0007044)3.56790830
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.56462429
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.55782380
47platelet dense granule organization (GO:0060155)3.51142997
48water-soluble vitamin biosynthetic process (GO:0042364)3.46465829
49piRNA metabolic process (GO:0034587)3.45570059
50hypotonic response (GO:0006971)3.42675919
51protein polyglutamylation (GO:0018095)3.40865835
52indole-containing compound catabolic process (GO:0042436)3.35082230
53indolalkylamine catabolic process (GO:0046218)3.35082230
54tryptophan catabolic process (GO:0006569)3.35082230
55cellular response to ATP (GO:0071318)3.32613477
56interleukin-1-mediated signaling pathway (GO:0070498)3.30082583
57cardiac muscle cell action potential involved in contraction (GO:0086002)3.30028586
58membrane repolarization (GO:0086009)3.26569031
59cornea development in camera-type eye (GO:0061303)3.26319606
60indolalkylamine metabolic process (GO:0006586)3.22209399
61kynurenine metabolic process (GO:0070189)3.20359514
62collagen fibril organization (GO:0030199)3.20107520
63polyol transport (GO:0015791)3.17115279
64cellular ketone body metabolic process (GO:0046950)3.15754179
65retinal metabolic process (GO:0042574)3.14611052
66regulation of skeletal muscle contraction (GO:0014819)3.13728524
67positive regulation of osteoblast proliferation (GO:0033690)3.13531483
68negative regulation of mast cell activation (GO:0033004)3.12887543
69cardiac muscle cell action potential (GO:0086001)3.11964734
70skin development (GO:0043588)3.10141871
71negative regulation of complement activation (GO:0045916)3.09863033
72phosphatidylinositol acyl-chain remodeling (GO:0036149)3.06806131
73fatty acid elongation (GO:0030497)3.06310804
74axoneme assembly (GO:0035082)3.02462686
75regulation of cilium movement (GO:0003352)3.02307858
76regulation of cardioblast differentiation (GO:0051890)3.01750623
77primary alcohol metabolic process (GO:0034308)3.00396041
78protein-cofactor linkage (GO:0018065)2.99002186
79preassembly of GPI anchor in ER membrane (GO:0016254)2.98877617
80sulfation (GO:0051923)2.97963555
81kidney morphogenesis (GO:0060993)2.96787836
82regulation of action potential (GO:0098900)2.94257473
83gamma-aminobutyric acid transport (GO:0015812)2.94126636
84peptidyl-proline hydroxylation (GO:0019511)2.93107427
85purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.92628154
863-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.92628154
87nonmotile primary cilium assembly (GO:0035058)2.91974849
88neuronal action potential (GO:0019228)2.91879781
89epithelial cilium movement (GO:0003351)2.91867561
90positive regulation of hair cycle (GO:0042635)2.91841796
91positive regulation of hair follicle development (GO:0051798)2.91841796
92virion attachment to host cell (GO:0019062)2.91720000
93adhesion of symbiont to host cell (GO:0044650)2.91720000
94DNA methylation involved in gamete generation (GO:0043046)2.91593274
95mannosylation (GO:0097502)2.90364408
96negative regulation of telomere maintenance (GO:0032205)2.88686463
97multicellular organism reproduction (GO:0032504)2.87561484
98ketone body metabolic process (GO:1902224)2.85232783
994-hydroxyproline metabolic process (GO:0019471)2.84048563
100protein complex biogenesis (GO:0070271)2.83842570
101photoreceptor cell development (GO:0042461)2.81945658
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.81921079
103NADH dehydrogenase complex assembly (GO:0010257)2.81921079
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81921079
105positive regulation of fatty acid transport (GO:2000193)2.78363882
106retinal cone cell development (GO:0046549)2.78211804
107nephron epithelium morphogenesis (GO:0072088)2.75010655
108nephron tubule morphogenesis (GO:0072078)2.75010655
109behavioral response to ethanol (GO:0048149)2.74665229
110tryptophan metabolic process (GO:0006568)2.74557232
111regulation of keratinocyte differentiation (GO:0045616)2.74471417
112response to muscle activity (GO:0014850)2.73710406
113regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.70272787
114negative regulation of reactive oxygen species metabolic process (GO:2000378)2.70244743
115respiratory chain complex IV assembly (GO:0008535)2.69794011
116protein hydroxylation (GO:0018126)2.68162234
117auditory receptor cell stereocilium organization (GO:0060088)2.67216164
118phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64715243
119synaptic transmission, cholinergic (GO:0007271)2.64617584
120rhodopsin mediated signaling pathway (GO:0016056)2.63372866
121embryo implantation (GO:0007566)2.63153298
122eyelid development in camera-type eye (GO:0061029)2.62593633
123neural tube formation (GO:0001841)2.62388072
124protein K11-linked deubiquitination (GO:0035871)2.62380129
125mitochondrial respiratory chain complex assembly (GO:0033108)2.62237228
126reflex (GO:0060004)2.61692903
127dopamine transport (GO:0015872)2.61618106
128regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61391295
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61363138
130positive regulation of monocyte chemotaxis (GO:0090026)2.60684115
131somite development (GO:0061053)2.60683229
132collagen metabolic process (GO:0032963)2.59963800
133brown fat cell differentiation (GO:0050873)2.59316645
134regulation of nuclear cell cycle DNA replication (GO:0033262)2.59127355
135indole-containing compound metabolic process (GO:0042430)2.58077160
136xenobiotic catabolic process (GO:0042178)2.57728433
137phosphatidylserine acyl-chain remodeling (GO:0036150)2.57653882
138mitotic cell cycle arrest (GO:0071850)2.57400245
139wound healing, spreading of epidermal cells (GO:0035313)2.57394292
140interferon-gamma secretion (GO:0072643)2.57008758
141renal filtration (GO:0097205)2.56840191
142cellular biogenic amine catabolic process (GO:0042402)2.56415949
143amine catabolic process (GO:0009310)2.56415949
144eye photoreceptor cell development (GO:0042462)2.56036857
145transmission of nerve impulse (GO:0019226)2.55498732
146cilium morphogenesis (GO:0060271)2.55424948
147parturition (GO:0007567)2.55023160
148negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54791025
149fucosylation (GO:0036065)2.54329823
150reciprocal meiotic recombination (GO:0007131)2.54316157
151reciprocal DNA recombination (GO:0035825)2.54316157
152epithelial cell-cell adhesion (GO:0090136)2.54216523
153extracellular matrix disassembly (GO:0022617)2.53178966
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52665999
155photoreceptor cell maintenance (GO:0045494)2.51522508
156endodermal cell differentiation (GO:0035987)2.50915419
157regulation of natural killer cell differentiation (GO:0032823)2.50467062
158G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50349078
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.49642718
160multicellular organismal macromolecule metabolic process (GO:0044259)2.49205688
161negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48271782
162pyrimidine nucleobase catabolic process (GO:0006208)2.47836444
163negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.46935903
164primary amino compound metabolic process (GO:1901160)2.46807249
165keratinocyte development (GO:0003334)2.46549341
166startle response (GO:0001964)2.45566443
167GPI anchor metabolic process (GO:0006505)2.44540566
168cytidine metabolic process (GO:0046087)2.43312361
169cytidine catabolic process (GO:0006216)2.43312361
170cytidine deamination (GO:0009972)2.43312361
171protein localization to cilium (GO:0061512)2.42616884
172negative regulation of protein activation cascade (GO:2000258)2.42475323
173collagen catabolic process (GO:0030574)2.41575973
174protein heterotrimerization (GO:0070208)2.41526184
175wound healing (GO:0042060)2.41331690
176regulation of hippo signaling (GO:0035330)2.40594937
177glycerophospholipid catabolic process (GO:0046475)2.40557747
178retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40399577
179keratinocyte proliferation (GO:0043616)2.40099008
180adhesion of symbiont to host (GO:0044406)2.38702891
181cell adhesion mediated by integrin (GO:0033627)2.38246163
182phospholipid scrambling (GO:0017121)2.37967780
183multicellular organismal signaling (GO:0035637)2.37896481
184multicellular organismal metabolic process (GO:0044236)2.37504745
185negative regulation of keratinocyte proliferation (GO:0010839)2.36819208
186bone morphogenesis (GO:0060349)2.36159021
187iron ion import (GO:0097286)2.34140685
188folic acid transport (GO:0015884)2.33861741
189tight junction assembly (GO:0070830)2.33554866
190negative regulation of cell fate specification (GO:0009996)2.32229975
191lipoxygenase pathway (GO:0019372)2.32065124
192regulation of hair follicle development (GO:0051797)2.31534280
193multicellular organismal catabolic process (GO:0044243)2.28687004
194regulation of potassium ion transmembrane transporter activity (GO:1901016)2.28220111
195keratinization (GO:0031424)13.5575985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.15441303
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.04307963
3ZNF274_21170338_ChIP-Seq_K562_Hela3.93794218
4VDR_22108803_ChIP-Seq_LS180_Human3.88778641
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.45486547
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.23390511
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.16465604
8EZH2_22144423_ChIP-Seq_EOC_Human2.95636014
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94525439
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.87698257
11GBX2_23144817_ChIP-Seq_PC3_Human2.71316046
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38074743
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31231941
14P63_26484246_Chip-Seq_KERATINOCYTES_Human2.26182125
15IGF1R_20145208_ChIP-Seq_DFB_Human2.20623792
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09509611
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06965641
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06965641
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00653689
20TP63_17297297_ChIP-ChIP_HaCaT_Human11.2087406
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99406631
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90834332
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88576871
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88394681
25SOX2_20726797_ChIP-Seq_SW620_Human1.86511207
26EWS_26573619_Chip-Seq_HEK293_Human1.85321584
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.80107505
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.78869982
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78353540
30P300_19829295_ChIP-Seq_ESCs_Human1.78141619
31ER_23166858_ChIP-Seq_MCF-7_Human1.74439641
32FUS_26573619_Chip-Seq_HEK293_Human1.74403675
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69876759
34BCAT_22108803_ChIP-Seq_LS180_Human1.68285612
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.66687788
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63797630
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60674116
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60436852
39TAF15_26573619_Chip-Seq_HEK293_Human1.59339995
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58648211
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55654100
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53333536
43* TP53_22573176_ChIP-Seq_HFKS_Human1.53060262
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51840084
45CJUN_26792858_Chip-Seq_BT549_Human1.50498345
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48846107
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48272099
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.45457749
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45457749
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45317111
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45317111
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45194495
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.44680573
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43018504
55REST_21632747_ChIP-Seq_MESCs_Mouse1.42980193
56AR_25329375_ChIP-Seq_VCAP_Human1.42544556
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42460788
58IRF1_19129219_ChIP-ChIP_H3396_Human1.41578801
59TP53_18474530_ChIP-ChIP_U2OS_Human1.41348367
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39849169
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39738050
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39377540
63CBP_20019798_ChIP-Seq_JUKART_Human1.39377540
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.39325145
65STAT3_23295773_ChIP-Seq_U87_Human1.38036144
66NCOR_22424771_ChIP-Seq_293T_Human1.37643205
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37132067
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.37079823
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35088052
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33768047
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33739169
72AR_20517297_ChIP-Seq_VCAP_Human1.33360256
73GATA4_25053715_ChIP-Seq_YYC3_Human1.33343576
74TCF4_23295773_ChIP-Seq_U87_Human1.32624412
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31951064
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31948485
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.31712015
78* HOXB7_26014856_ChIP-Seq_BT474_Human1.31584797
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31233535
80MYC_18940864_ChIP-ChIP_HL60_Human1.30767095
81SMAD4_21799915_ChIP-Seq_A2780_Human1.30627757
82ERA_21632823_ChIP-Seq_H3396_Human1.29643546
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28147854
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.27988016
85TCF4_22108803_ChIP-Seq_LS180_Human1.27542733
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26993056
87TP63_23658742_ChIP-Seq_EP156T_Human1.26894890
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.26846797
89RACK7_27058665_Chip-Seq_MCF-7_Human1.26217838
90KLF5_25053715_ChIP-Seq_YYC3_Human1.25556865
91NANOG_19829295_ChIP-Seq_ESCs_Human1.25175227
92SOX2_19829295_ChIP-Seq_ESCs_Human1.25175227
93GATA3_24758297_ChIP-Seq_MCF-7_Human1.24742094
94MYC_19829295_ChIP-Seq_ESCs_Human1.24726624
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24479909
96* ATF3_27146783_Chip-Seq_COLON_Human1.23733492
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23425591
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22502651
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21762025
100* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20440649
101DROSHA_22980978_ChIP-Seq_HELA_Human1.20056781
102NANOG_20526341_ChIP-Seq_ESCs_Human1.18026532
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17726329
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17290803
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17162678
106CLOCK_20551151_ChIP-Seq_293T_Human1.15843564
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15803328
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15342515
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15163402
110RNF2_27304074_Chip-Seq_NSC_Mouse1.14492545
111AR_21572438_ChIP-Seq_LNCaP_Human1.14009624
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13233459
113* TAF2_19829295_ChIP-Seq_ESCs_Human1.12880027
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12856673
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12238178
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.11411596
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09182729
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.09110640
119RUNX2_22187159_ChIP-Seq_PCA_Human1.08896918
120CDX2_20551321_ChIP-Seq_CACO-2_Human1.08618429
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08530893
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08455395
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.07625269
124JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07360098
125ZNF263_19887448_ChIP-Seq_K562_Human1.06417351
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.06395876
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.05707637
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05654471
129RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05294345
130EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05294345
131GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05221810
132GABP_17652178_ChIP-ChIP_JURKAT_Human1.05036335
133EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04961595
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04425612
135P53_21459846_ChIP-Seq_SAOS-2_Human1.04398895
136NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04307876
137* REST_18959480_ChIP-ChIP_MESCs_Mouse1.04235169
138AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03262762
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02930449
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02534186
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.01982587
142GATA2_21666600_ChIP-Seq_HMVEC_Human1.01932692
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01121754
144HTT_18923047_ChIP-ChIP_STHdh_Human1.00601716
145TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00360866
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99964599
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.99293379
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.98250249
149FLI1_21867929_ChIP-Seq_TH2_Mouse0.97968376
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97904977
151FOXH1_21741376_ChIP-Seq_ESCs_Human0.96748201
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.96074123
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95943255
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95184558
155EGR1_19032775_ChIP-ChIP_M12_Human0.92835045
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92191458
157RXR_22108803_ChIP-Seq_LS180_Human0.91908045
158AHR_22903824_ChIP-Seq_MCF-7_Human0.91770760
159SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90967146
160TP63_22573176_ChIP-Seq_HFKS_Human0.90838042
161* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90095527
162NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89975492
163UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87273954
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.87240842
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.86565107
166CTCF_27219007_Chip-Seq_Bcells_Human0.86376849
167FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84862905
168SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84563704
169SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84483304
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82866551
171CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82280368
172GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81781278
173JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81464326
174SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80407471
175NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79098949
176NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79098949
177NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78419766
178GATA6_21074721_ChIP-Seq_CACO-2_Human0.78341212
179GATA6_25053715_ChIP-Seq_YYC3_Human0.77952298
180* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77524319
181TP53_20018659_ChIP-ChIP_R1E_Mouse0.77187477
182SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77149628
183AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77130028
184P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76461545
185ERG_20517297_ChIP-Seq_VCAP_Human0.75772236
186EZH2_27294783_Chip-Seq_ESCs_Mouse0.75695616
187LXR_22292898_ChIP-Seq_THP-1_Human0.75644354
188SPI1_20517297_ChIP-Seq_HL60_Human0.75541611
189NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75349139
190VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74989588
191EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.74812481
192SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74355990
193TBX20_22328084_ChIP-Seq_HEART_Mouse0.74279170
194TBX20_22080862_ChIP-Seq_HEART_Mouse0.74279170
195SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.73419407
196SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.73390950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.10834923
2MP0002796_impaired_skin_barrier5.66768971
3MP0000579_abnormal_nail_morphology5.64791078
4MP0008004_abnormal_stomach_pH4.98681862
5MP0010234_abnormal_vibrissa_follicle4.04573574
6MP0005501_abnormal_skin_physiology3.76861020
7MP0004043_abnormal_pH_regulation3.66367405
8MP0003705_abnormal_hypodermis_morpholog3.63546004
9MP0000383_abnormal_hair_follicle3.26004142
10MP0000467_abnormal_esophagus_morphology3.24666987
11MP0003011_delayed_dark_adaptation3.08636896
12MP0010678_abnormal_skin_adnexa3.07260888
13MP0008438_abnormal_cutaneous_collagen3.01034136
14MP0002060_abnormal_skin_morphology2.77957481
15MP0001216_abnormal_epidermal_layer2.62987056
16MP0004885_abnormal_endolymph2.62576638
17MP0003566_abnormal_cell_adhesion2.59479073
18MP0003941_abnormal_skin_development2.57167081
19MP0000762_abnormal_tongue_morphology2.51889592
20MP0005551_abnormal_eye_electrophysiolog2.50647930
21MP0001986_abnormal_taste_sensitivity2.50567455
22MP0003195_calcinosis2.44922193
23MP0008877_abnormal_DNA_methylation2.44392266
24MP0008875_abnormal_xenobiotic_pharmacok2.41059334
25MP0001968_abnormal_touch/_nociception2.40286097
26MP0010771_integument_phenotype2.39180557
27MP0003453_abnormal_keratinocyte_physiol2.33790723
28MP0000647_abnormal_sebaceous_gland2.27201514
29MP0000569_abnormal_digit_pigmentation2.21992052
30MP0000377_abnormal_hair_follicle2.16824795
31MP0000427_abnormal_hair_cycle2.16457148
32MP0004381_abnormal_hair_follicle2.14358321
33MP0002837_dystrophic_cardiac_calcinosis2.10228746
34MP0002638_abnormal_pupillary_reflex2.07732005
35MP0003787_abnormal_imprinting2.01316768
36MP0008872_abnormal_physiological_respon1.95800600
37MP0002102_abnormal_ear_morphology1.95173752
38MP0002736_abnormal_nociception_after1.94952197
39MP0004947_skin_inflammation1.94530826
40MP0002098_abnormal_vibrissa_morphology1.93372510
41MP0003136_yellow_coat_color1.91051040
42MP0006072_abnormal_retinal_apoptosis1.89730399
43MP0002876_abnormal_thyroid_physiology1.87375711
44MP0005253_abnormal_eye_physiology1.86382377
45MP0004142_abnormal_muscle_tone1.84982247
46MP0009046_muscle_twitch1.84870794
47MP0003646_muscle_fatigue1.84649858
48MP0006292_abnormal_olfactory_placode1.83690602
49MP0005023_abnormal_wound_healing1.81256432
50MP0005646_abnormal_pituitary_gland1.81214752
51MP0005503_abnormal_tendon_morphology1.78827030
52MP0001958_emphysema1.76089514
53MP0002234_abnormal_pharynx_morphology1.72492137
54MP0009745_abnormal_behavioral_response1.71894132
55MP0005174_abnormal_tail_pigmentation1.70573035
56MP0004019_abnormal_vitamin_homeostasis1.64294540
57MP0002272_abnormal_nervous_system1.60852651
58MP0005248_abnormal_Harderian_gland1.60085489
59MP0002653_abnormal_ependyma_morphology1.55346572
60MP0004272_abnormal_basement_membrane1.55299137
61MP0000566_synostosis1.55164634
62MP0000631_abnormal_neuroendocrine_gland1.54305934
63MP0003878_abnormal_ear_physiology1.48161860
64MP0005377_hearing/vestibular/ear_phenot1.48161860
65MP0001501_abnormal_sleep_pattern1.46480752
66MP0002095_abnormal_skin_pigmentation1.45983965
67MP0001243_abnormal_dermal_layer1.43460607
68MP0001502_abnormal_circadian_rhythm1.42796321
69MP0001346_abnormal_lacrimal_gland1.41813010
70MP0003880_abnormal_central_pattern1.40467987
71MP0002254_reproductive_system_inflammat1.39550582
72MP0004133_heterotaxia1.38046877
73MP0005423_abnormal_somatic_nervous1.35831195
74MP0001191_abnormal_skin_condition1.35466634
75MP0004147_increased_porphyrin_level1.35250518
76MP0006276_abnormal_autonomic_nervous1.32887673
77MP0001984_abnormal_olfaction1.30365610
78MP0002160_abnormal_reproductive_system1.27892952
79MP0002938_white_spotting1.25678948
80MP0004742_abnormal_vestibular_system1.24956214
81MP0005389_reproductive_system_phenotype1.24299946
82MP0001970_abnormal_pain_threshold1.23642525
83MP0001486_abnormal_startle_reflex1.22988623
84MP0001485_abnormal_pinna_reflex1.22798506
85MP0002735_abnormal_chemical_nociception1.21970390
86MP0002733_abnormal_thermal_nociception1.19905800
87MP0005451_abnormal_body_composition1.19240335
88MP0001919_abnormal_reproductive_system1.18537315
89MP0002064_seizures1.17517705
90MP0002572_abnormal_emotion/affect_behav1.17266485
91MP0002138_abnormal_hepatobiliary_system1.16931660
92MP0000367_abnormal_coat/_hair1.16847585
93MP0006054_spinal_hemorrhage1.15110896
94MP0002557_abnormal_social/conspecific_i1.14737249
95MP0009931_abnormal_skin_appearance1.13489866
96MP0002928_abnormal_bile_duct1.12618018
97MP0000537_abnormal_urethra_morphology1.09652684
98MP0002163_abnormal_gland_morphology1.07403002
99MP0000465_gastrointestinal_hemorrhage1.06940272
100MP0005084_abnormal_gallbladder_morpholo1.06612891
101MP0004185_abnormal_adipocyte_glucose1.06027673
102MP0010386_abnormal_urinary_bladder1.06011072
103MP0003283_abnormal_digestive_organ1.05950476
104MP0005379_endocrine/exocrine_gland_phen1.05753559
105MP0005410_abnormal_fertilization1.05725371
106MP0001905_abnormal_dopamine_level1.03683852
107MP0005195_abnormal_posterior_eye1.03444570
108MP0000372_irregular_coat_pigmentation1.01962395
109MP0004145_abnormal_muscle_electrophysio1.00388489
110MP0005409_darkened_coat_color1.00047541
111MP0009384_cardiac_valve_regurgitation0.99106061
112MP0002108_abnormal_muscle_morphology0.98850986
113MP0005666_abnormal_adipose_tissue0.96786264
114MP0003635_abnormal_synaptic_transmissio0.96047153
115MP0002090_abnormal_vision0.95981957
116MP0001849_ear_inflammation0.92759019
117MP0002063_abnormal_learning/memory/cond0.92114192
118MP0002067_abnormal_sensory_capabilities0.90780279
119MP0000230_abnormal_systemic_arterial0.89253988
120MP0005386_behavior/neurological_phenoty0.88639789
121MP0004924_abnormal_behavior0.88639789
122MP0001765_abnormal_ion_homeostasis0.88033715
123MP0005365_abnormal_bile_salt0.87782324
124MP0002752_abnormal_somatic_nervous0.87400934
125MP0000026_abnormal_inner_ear0.86516444
126MP0003718_maternal_effect0.85192302
127MP0002282_abnormal_trachea_morphology0.84474893
128MP0001542_abnormal_bone_strength0.84045791
129MP0001756_abnormal_urination0.84029714
130MP0003698_abnormal_male_reproductive0.83536426
131MP0005332_abnormal_amino_acid0.83530733
132MP0000778_abnormal_nervous_system0.83129974
133MP0001529_abnormal_vocalization0.82995676
134MP0005645_abnormal_hypothalamus_physiol0.82235175
135MP0000470_abnormal_stomach_morphology0.81294798
136MP0001851_eye_inflammation0.80400093
137MP0004264_abnormal_extraembryonic_tissu0.78089585
138MP0005083_abnormal_biliary_tract0.77789180
139MP0008995_early_reproductive_senescence0.77482548
140MP0005623_abnormal_meninges_morphology0.77269786
141MP0004215_abnormal_myocardial_fiber0.77081936
142MP0000627_abnormal_mammary_gland0.76703902
143MP0002277_abnormal_respiratory_mucosa0.74059817
144MP0002734_abnormal_mechanical_nocicepti0.71038502
145MP0003252_abnormal_bile_duct0.70965742
146MP0005085_abnormal_gallbladder_physiolo0.70800428
147MP0003191_abnormal_cellular_cholesterol0.70635650
148MP0010352_gastrointestinal_tract_polyps0.69992755
149MP0003755_abnormal_palate_morphology0.67703764
150MP0004858_abnormal_nervous_system0.67252032
151MP0005375_adipose_tissue_phenotype0.67116770
152MP0009053_abnormal_anal_canal0.65657747
153MP0003436_decreased_susceptibility_to0.65021561
154MP0005508_abnormal_skeleton_morphology0.62874580
155MP0005171_absent_coat_pigmentation0.61966334
156MP0005367_renal/urinary_system_phenotyp0.61819338
157MP0000516_abnormal_urinary_system0.61819338
158MP0001727_abnormal_embryo_implantation0.59201733
159MP0004782_abnormal_surfactant_physiolog0.58392605
160MP0000750_abnormal_muscle_regeneration0.57134431
161MP0005193_abnormal_anterior_eye0.56182689
162MP0008775_abnormal_heart_ventricle0.55232839
163MP0001533_abnormal_skeleton_physiology0.54941388
164MP0002971_abnormal_brown_adipose0.53225898
165MP0005390_skeleton_phenotype0.52174068
166MP0003279_aneurysm0.51940498
167MP0010030_abnormal_orbit_morphology0.51526221
168MP0003045_fibrosis0.48969675
169MP0010368_abnormal_lymphatic_system0.47742302
170MP0002111_abnormal_tail_morphology0.46652854
171MP0003091_abnormal_cell_migration0.44112076
172MP0005257_abnormal_intraocular_pressure0.43960130
173MP0001324_abnormal_eye_pigmentation0.42868730
174MP0003448_altered_tumor_morphology0.42319724
175MP0001340_abnormal_eyelid_morphology0.41684084
176MP0003938_abnormal_ear_development0.40655360
177MP0002933_joint_inflammation0.40608905
178MP0001188_hyperpigmentation0.39368076
179MP0000733_abnormal_muscle_development0.38105476
180MP0000538_abnormal_urinary_bladder0.37660875
181MP0005197_abnormal_uvea_morphology0.37391822
182MP0002896_abnormal_bone_mineralization0.37086840
183MP0002233_abnormal_nose_morphology0.36919953
184MP0000749_muscle_degeneration0.36806001
185MP0003724_increased_susceptibility_to0.35426095
186MP0000163_abnormal_cartilage_morphology0.33686652
187MP0008789_abnormal_olfactory_epithelium0.33568428

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)6.88544516
2Thick nail (HP:0001805)6.76195237
3Oral leukoplakia (HP:0002745)5.97533197
4Plantar hyperkeratosis (HP:0007556)5.82233961
5Ventricular fibrillation (HP:0001663)5.40528814
6Right ventricular cardiomyopathy (HP:0011663)5.39152596
7Alopecia of scalp (HP:0002293)5.26202602
8Milia (HP:0001056)5.26200617
9Fragile nails (HP:0001808)5.14012153
10Palmoplantar hyperkeratosis (HP:0000972)5.08932620
11Increased IgE level (HP:0003212)4.92113512
12Palmar hyperkeratosis (HP:0010765)4.78284961
13Atrophic scars (HP:0001075)4.69805354
14Follicular hyperkeratosis (HP:0007502)4.58602203
15Woolly hair (HP:0002224)4.53346494
16Hypotrichosis (HP:0001006)4.28724698
17Pancreatic cysts (HP:0001737)4.28404775
18Abnormal blistering of the skin (HP:0008066)4.14090288
19Abnormality of midbrain morphology (HP:0002418)3.85744278
20Molar tooth sign on MRI (HP:0002419)3.85744278
21Pancreatic fibrosis (HP:0100732)3.77459682
22Nail dystrophy (HP:0008404)3.67927326
23True hermaphroditism (HP:0010459)3.54822253
24Nephronophthisis (HP:0000090)3.52168165
25Attenuation of retinal blood vessels (HP:0007843)3.48253152
26Pili torti (HP:0003777)3.41400824
27Laryngomalacia (HP:0001601)3.32703225
28Abnormality of the renal cortex (HP:0011035)3.31000068
29Abnormality of the renal medulla (HP:0100957)3.30608051
30Type II lissencephaly (HP:0007260)3.17709654
31Tubular atrophy (HP:0000092)3.17535166
32Syncope (HP:0001279)3.08598984
33Corneal dystrophy (HP:0001131)3.01164853
34Hyperventilation (HP:0002883)2.99697927
35Distal lower limb muscle weakness (HP:0009053)2.98915825
36Muscle fiber splitting (HP:0003555)2.92568470
37Abnormal drinking behavior (HP:0030082)2.88784931
38Polydipsia (HP:0001959)2.88784931
39Pendular nystagmus (HP:0012043)2.87699692
40Vascular calcification (HP:0004934)2.82625443
41Erythema (HP:0010783)2.81901865
42Decreased circulating renin level (HP:0003351)2.79881958
43Abnormal rod and cone electroretinograms (HP:0008323)2.79298651
44Congenital ichthyosiform erythroderma (HP:0007431)2.76787105
45Premature rupture of membranes (HP:0001788)2.75913547
46Medial flaring of the eyebrow (HP:0010747)2.75148634
47Decreased central vision (HP:0007663)2.74007931
48Chronic hepatic failure (HP:0100626)2.73806291
49Abnormality of alanine metabolism (HP:0010916)2.72768477
50Hyperalaninemia (HP:0003348)2.72768477
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72768477
52Abolished electroretinogram (ERG) (HP:0000550)2.71567760
53Cardiovascular calcification (HP:0011915)2.70645247
54Furrowed tongue (HP:0000221)2.69934297
55Cystic liver disease (HP:0006706)2.63719367
56Severe Myopia (HP:0011003)2.61829516
57Ridged nail (HP:0001807)2.60109210
58Palmoplantar keratoderma (HP:0000982)2.54774591
59Erythroderma (HP:0001019)2.54350623
60Polyuria (HP:0000103)2.53581476
61Chorioretinal atrophy (HP:0000533)2.52519391
62Type 1 muscle fiber predominance (HP:0003803)2.51319568
63Protrusio acetabuli (HP:0003179)2.48525302
64Corneal erosion (HP:0200020)2.48256480
65Anonychia (HP:0001798)2.47609626
66Hyperphosphatemia (HP:0002905)2.44383795
67Hydroxyprolinuria (HP:0003080)2.39026969
68Abnormality of proline metabolism (HP:0010907)2.39026969
69Sclerocornea (HP:0000647)2.37851927
70Fatigable weakness (HP:0003473)2.35519732
71Abnormality of the neuromuscular junction (HP:0003398)2.35519732
72Neonatal short-limb short stature (HP:0008921)2.35064220
73Ventricular tachycardia (HP:0004756)2.33220079
74Prolonged QT interval (HP:0001657)2.28812669
75Bony spicule pigmentary retinopathy (HP:0007737)2.28549193
76Advanced eruption of teeth (HP:0006288)2.28199524
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27680118
78Lissencephaly (HP:0001339)2.26446052
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.26290605
80Increased corneal curvature (HP:0100692)2.25759482
81Keratoconus (HP:0000563)2.25759482
82Natal tooth (HP:0000695)2.25034900
83Hypohidrosis (HP:0000966)2.22489215
84Pustule (HP:0200039)2.20938634
85Rib fusion (HP:0000902)2.20111005
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.19970753
87Genetic anticipation (HP:0003743)2.17917568
88Increased connective tissue (HP:0009025)2.17217403
89Abnormal biliary tract physiology (HP:0012439)2.16132882
90Bile duct proliferation (HP:0001408)2.16132882
91Fragile skin (HP:0001030)2.14064579
92Congenital hepatic fibrosis (HP:0002612)2.11976651
93Conjunctival hamartoma (HP:0100780)2.11676601
94Cerebellar dysplasia (HP:0007033)2.11672424
95Aplasia/Hypoplasia of the patella (HP:0006498)2.10040303
96Gait imbalance (HP:0002141)2.10007670
97Ventricular arrhythmia (HP:0004308)2.07193475
98Concave nail (HP:0001598)2.06703512
99Absent/shortened dynein arms (HP:0200106)2.06645645
100Dynein arm defect of respiratory motile cilia (HP:0012255)2.06645645
101Gaze-evoked nystagmus (HP:0000640)2.06263508
102Curly hair (HP:0002212)2.06250360
103Parakeratosis (HP:0001036)2.06184281
104Abnormal hair laboratory examination (HP:0003328)2.05624910
105Inability to walk (HP:0002540)2.05603412
106Abnormal urine output (HP:0012590)2.03763841
107Progressive cerebellar ataxia (HP:0002073)2.03754056
108Aplasia cutis congenita (HP:0001057)2.03538410
109Congenital primary aphakia (HP:0007707)2.02594146
110Nephrogenic diabetes insipidus (HP:0009806)2.01155311
111Abnormality of nail color (HP:0100643)11.0418832
112Methylmalonic aciduria (HP:0012120)1.99958208
113Patellar aplasia (HP:0006443)1.99380558
114Aplasia/hypoplasia of the uterus (HP:0008684)1.98282048
115Hypothermia (HP:0002045)1.97543396
116Upper limb muscle weakness (HP:0003484)1.97034248
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.96226679
118Congenital, generalized hypertrichosis (HP:0004540)1.95590101
119Calcaneovalgus deformity (HP:0001848)1.95434859
120Distal lower limb amyotrophy (HP:0008944)1.94006376
121Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93852644
122Tarsal synostosis (HP:0008368)1.89292629
123Anencephaly (HP:0002323)1.89001153
124Methylmalonic acidemia (HP:0002912)1.88500575
125Eczematoid dermatitis (HP:0000976)1.87901354
126Muscle fiber inclusion bodies (HP:0100299)1.87850060
127Abnormality of the dental pulp (HP:0006479)1.87439846
128Abnormality of renal excretion (HP:0011036)1.85808432
129Optic disc pallor (HP:0000543)1.85493760
130Hyperhidrosis (HP:0000975)1.84867625
131Male pseudohermaphroditism (HP:0000037)1.84188983
132Upper limb amyotrophy (HP:0009129)1.84151163
133Distal upper limb amyotrophy (HP:0007149)1.84151163
134Large for gestational age (HP:0001520)1.83890027
135Abnormality of renin-angiotensin system (HP:0000847)1.82448593
136Asplenia (HP:0001746)1.82346186
137Amelogenesis imperfecta (HP:0000705)1.82119329
138Retinal dysplasia (HP:0007973)1.82102028
139Renal cortical cysts (HP:0000803)1.82060913
140Absent speech (HP:0001344)1.81758618
141Mitochondrial inheritance (HP:0001427)1.81479711
142Acute necrotizing encephalopathy (HP:0006965)1.81213468
143Ulnar deviation of the wrist (HP:0003049)1.81211737
144Broad-based gait (HP:0002136)1.80898687
145Round ear (HP:0100830)1.80867150
146Choroideremia (HP:0001139)1.80373176
147Hypoplasia of dental enamel (HP:0006297)1.80145222
148Hand muscle atrophy (HP:0009130)1.80144294
149Hypokalemic alkalosis (HP:0001949)1.80000977
150Pachygyria (HP:0001302)1.79995287
151Hypoplasia of the uterus (HP:0000013)1.79793230
152Distal arthrogryposis (HP:0005684)1.79701932
153Bilateral sensorineural hearing impairment (HP:0008619)1.77981661
154Febrile seizures (HP:0002373)1.77827997
155Abnormality of the pons (HP:0007361)1.76346243
156Stomach cancer (HP:0012126)1.76298755
157Genital tract atresia (HP:0001827)1.75348359
158Severe muscular hypotonia (HP:0006829)1.74898246
159Hemiparesis (HP:0001269)1.74586667
160Recurrent corneal erosions (HP:0000495)1.73801540
161Ectropion (HP:0000656)1.73455954
162Increased CSF lactate (HP:0002490)1.73284395
163Ketosis (HP:0001946)1.73151576
164Fair hair (HP:0002286)1.73070492
165Tubulointerstitial fibrosis (HP:0005576)1.72903135
166Vaginal atresia (HP:0000148)1.72656539
167Blepharitis (HP:0000498)1.71732183
168Abnormality of molar morphology (HP:0011070)1.71441129
169Abnormality of molar (HP:0011077)1.71441129
170Cervical subluxation (HP:0003308)1.71405169
171Tachypnea (HP:0002789)1.70841739
172Hypoplasia of the pons (HP:0012110)1.70324899
173Abnormality of the fingernails (HP:0001231)1.70024957
174Synostosis involving bones of the feet (HP:0009140)1.69596610
175Synostosis involving bones of the lower limbs (HP:0009138)1.69596610
176Hyporeflexia of lower limbs (HP:0002600)1.69490882
177Optic nerve hypoplasia (HP:0000609)1.69159689
178Hip contracture (HP:0003273)1.68935400
179Progressive inability to walk (HP:0002505)1.68675941
180Nemaline bodies (HP:0003798)1.67805533
181Brittle hair (HP:0002299)1.67471473
182Postaxial foot polydactyly (HP:0001830)1.66530720
183Deformed tarsal bones (HP:0008119)1.66461409
184Abnormality of the fovea (HP:0000493)1.65695404
185Exercise-induced muscle cramps (HP:0003710)1.65403385
186Stridor (HP:0010307)1.64683055
187Myopathic facies (HP:0002058)1.64068961
188Congenital stationary night blindness (HP:0007642)1.62824019
189Lip pit (HP:0100267)1.62763483
190Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61509352
191Carious teeth (HP:0000670)1.61331367
192Peritonitis (HP:0002586)1.60833125
193Pterygium (HP:0001059)1.58863178
194Abnormality of the gastric mucosa (HP:0004295)1.58778597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.74179354
2FER4.10634152
3ADRBK23.49805953
4EPHB23.10082191
5MST1R3.09663464
6MST42.98107052
7TRPM72.87294298
8BMPR1B2.83616462
9TLK12.79995273
10ERN12.78643391
11TTN2.78610079
12MAP4K22.65335457
13ZAK2.63609290
14PINK12.57178494
15GRK12.49368489
16WNK32.42482499
17TXK2.29142145
18ACVR1B2.28283888
19STK392.26924608
20EPHA32.20408296
21TAOK32.16576328
22MAPKAPK32.13810375
23LATS12.08692685
24EPHB12.00163120
25PIK3CG1.92621023
26DMPK1.92548882
27MAP3K31.81363906
28EEF2K1.80475324
29BLK1.79905036
30LATS21.78166569
31MAPK131.72717613
32WNK41.71519417
33RIPK11.66426190
34PIM21.62650170
35ALK1.59338694
36CASK1.57416839
37MAP3K41.55984643
38STK38L1.50316333
39MAPK151.49800060
40INSRR1.47634324
41FGFR41.44220550
42DAPK21.42952891
43OXSR11.39258183
44ERBB31.37546512
45TESK11.35126776
46NME11.33691235
47MUSK1.33196603
48ADRBK11.27471416
49DDR21.26118895
50FGFR31.25886821
51PDK21.23981077
52PAK31.19461832
53DYRK21.15051195
54TRIB31.09865583
55BCKDK1.08453597
56MET1.06225304
57JAK11.06107455
58TIE11.04904913
59MAP2K61.03175993
60MARK11.03070873
61PTK20.97907922
62PTK60.97766173
63OBSCN0.93318783
64TAOK10.92298706
65LRRK20.90467196
66IKBKB0.89920531
67PRKCI0.88882219
68CSNK1G20.88658878
69PRKAA20.87917022
70STK100.87174115
71PDGFRA0.85960976
72PNCK0.84981200
73VRK10.84814642
74MAP3K140.83547949
75RPS6KB20.82252866
76WNK10.82164433
77SIK20.81696546
78MAP2K70.80861124
79FGFR10.79944787
80PHKG20.79757652
81PHKG10.79757652
82BMX0.79666537
83PRKCG0.78857508
84CSNK1G10.78639268
85IRAK30.78128125
86BCR0.77668317
87TRIM280.76757442
88MAP3K90.75303996
89MAP2K10.74924927
90CSNK1G30.74647598
91BRSK20.73770875
92TYK20.72984464
93STK30.69189694
94CDK60.68831501
95NEK20.67256673
96MKNK20.66172563
97PLK20.64179061
98CAMK1D0.64155564
99TNIK0.63172249
100PRKCE0.61645107
101CSNK1A1L0.61281034
102IRAK10.60645921
103FGFR20.60331505
104FRK0.59464042
105ROCK10.59411733
106MAP3K130.59370747
107TEC0.58388919
108RPS6KA50.56961129
109LIMK10.56404903
110EPHA40.54845259
111PTK2B0.54804961
112CHUK0.54388873
113VRK20.54033737
114CAMK10.53928326
115STK110.53362817
116PRKCQ0.52607580
117NEK60.52348887
118PKN10.51457335
119TGFBR20.51410141
120MAPKAPK50.50849838
121NTRK30.50541382
122STK240.50395456
123GRK50.50046646
124NTRK20.49203091
125MAP3K60.48982237
126ITK0.48569618
127CAMK2A0.48435356
128JAK20.48400386
129EIF2AK20.47731519
130HCK0.46874314
131MAPKAPK20.46743451
132TGFBR10.46370636
133PRKACA0.46041409
134NUAK10.46039409
135MAP3K70.45891419
136SIK10.45858551
137TYRO30.45764079
138CSK0.45462991
139PRKD10.43724530
140NLK0.43613207
141ROCK20.43218784
142MAP3K20.42701438
143MAP2K20.41827370
144CSNK1A10.41383113
145WEE10.41103371
146TAF10.38962977
147TNK20.37284119
148ERBB20.34907250
149PLK40.34331586
150CAMK1G0.33783663
151PKN20.33650419
152SRC0.33318944
153PRKCZ0.33221830
154CSNK1D0.30967042
155RPS6KA10.30053843
156RPS6KA60.29687175
157PAK40.29324606
158PDGFRB0.29152244
159PIK3CA0.28364972
160ZAP700.27312702
161CAMKK10.27163544
162PAK20.25621769
163PDK40.25286837
164PDK30.25286837
165RPS6KA40.25175957
166PRKCD0.23420156
167MAP2K30.23280731
168PRKCA0.23103286
169LMTK20.22795081
170MTOR0.22718783
171PDPK10.22374796
172CAMKK20.21907977
173AKT20.21249273

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.37538450
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.85134043
3Nitrogen metabolism_Homo sapiens_hsa009102.75907912
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40013960
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36609284
6Protein digestion and absorption_Homo sapiens_hsa049742.29382532
7Arachidonic acid metabolism_Homo sapiens_hsa005902.25311372
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24995756
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21172373
10Histidine metabolism_Homo sapiens_hsa003402.17771604
11Retinol metabolism_Homo sapiens_hsa008302.16160011
12Oxidative phosphorylation_Homo sapiens_hsa001902.12608832
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07386077
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01268608
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91511075
16Phenylalanine metabolism_Homo sapiens_hsa003601.86300425
17Nicotine addiction_Homo sapiens_hsa050331.85953518
18Fat digestion and absorption_Homo sapiens_hsa049751.83507564
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.82219028
20Butanoate metabolism_Homo sapiens_hsa006501.71901115
21Linoleic acid metabolism_Homo sapiens_hsa005911.71312131
22Fatty acid elongation_Homo sapiens_hsa000621.71290484
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70126438
24Ether lipid metabolism_Homo sapiens_hsa005651.66942729
25Focal adhesion_Homo sapiens_hsa045101.66327082
26Basal transcription factors_Homo sapiens_hsa030221.65251091
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.65081265
28RNA polymerase_Homo sapiens_hsa030201.62201947
29beta-Alanine metabolism_Homo sapiens_hsa004101.61822299
30Amoebiasis_Homo sapiens_hsa051461.60948350
31Homologous recombination_Homo sapiens_hsa034401.60942850
32Selenocompound metabolism_Homo sapiens_hsa004501.60792713
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56670747
34Parkinsons disease_Homo sapiens_hsa050121.52184083
35Proteoglycans in cancer_Homo sapiens_hsa052051.52111657
36Mineral absorption_Homo sapiens_hsa049781.49746221
37Taste transduction_Homo sapiens_hsa047421.45465781
38Phototransduction_Homo sapiens_hsa047441.42011136
39Small cell lung cancer_Homo sapiens_hsa052221.41896349
40Gastric acid secretion_Homo sapiens_hsa049711.41878757
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40868514
42Tight junction_Homo sapiens_hsa045301.39676568
43Protein export_Homo sapiens_hsa030601.39022153
44Tryptophan metabolism_Homo sapiens_hsa003801.38022897
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37744473
46Fanconi anemia pathway_Homo sapiens_hsa034601.37279385
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.35655933
48Vitamin digestion and absorption_Homo sapiens_hsa049771.34948017
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29980108
50Sulfur relay system_Homo sapiens_hsa041221.28770107
51Adherens junction_Homo sapiens_hsa045201.26938274
52Olfactory transduction_Homo sapiens_hsa047401.26456623
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.22465612
54Salivary secretion_Homo sapiens_hsa049701.19983222
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19360043
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.17090124
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16700674
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14181405
59Morphine addiction_Homo sapiens_hsa050321.13607293
60Chemical carcinogenesis_Homo sapiens_hsa052041.09517536
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09232430
62Tyrosine metabolism_Homo sapiens_hsa003501.09162391
63Hippo signaling pathway_Homo sapiens_hsa043901.07595018
64Serotonergic synapse_Homo sapiens_hsa047261.06929431
65One carbon pool by folate_Homo sapiens_hsa006701.04394218
66Bladder cancer_Homo sapiens_hsa052191.02678556
67Starch and sucrose metabolism_Homo sapiens_hsa005001.01751662
68RNA degradation_Homo sapiens_hsa030181.01245283
69Huntingtons disease_Homo sapiens_hsa050160.97803747
70Peroxisome_Homo sapiens_hsa041460.95545654
71Cardiac muscle contraction_Homo sapiens_hsa042600.95315617
72Toxoplasmosis_Homo sapiens_hsa051450.95029975
73Malaria_Homo sapiens_hsa051440.94757937
74Regulation of autophagy_Homo sapiens_hsa041400.94694236
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.94492400
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93419032
77Glutathione metabolism_Homo sapiens_hsa004800.93070860
78Alzheimers disease_Homo sapiens_hsa050100.92889620
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92122192
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.91993240
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91834934
82Caffeine metabolism_Homo sapiens_hsa002320.89885042
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88966860
84Glutamatergic synapse_Homo sapiens_hsa047240.88845330
85Circadian entrainment_Homo sapiens_hsa047130.88734293
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87783412
87Dilated cardiomyopathy_Homo sapiens_hsa054140.86349972
88Sphingolipid metabolism_Homo sapiens_hsa006000.86148726
89Insulin resistance_Homo sapiens_hsa049310.85968511
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85887105
91ABC transporters_Homo sapiens_hsa020100.85704542
92Insulin secretion_Homo sapiens_hsa049110.85541030
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.84777493
94Glioma_Homo sapiens_hsa052140.84449915
95Circadian rhythm_Homo sapiens_hsa047100.84155821
96Sulfur metabolism_Homo sapiens_hsa009200.83893726
97Collecting duct acid secretion_Homo sapiens_hsa049660.81318888
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80774338
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78840254
100Hepatitis C_Homo sapiens_hsa051600.75635997
101GABAergic synapse_Homo sapiens_hsa047270.75581873
102GnRH signaling pathway_Homo sapiens_hsa049120.75174368
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75021153
104TNF signaling pathway_Homo sapiens_hsa046680.74960860
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.74153596
106Salmonella infection_Homo sapiens_hsa051320.73972953
107Acute myeloid leukemia_Homo sapiens_hsa052210.71293546
108Pertussis_Homo sapiens_hsa051330.71209211
109mTOR signaling pathway_Homo sapiens_hsa041500.71081252
110PPAR signaling pathway_Homo sapiens_hsa033200.69117460
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.68456804
112Staphylococcus aureus infection_Homo sapiens_hsa051500.67321084
113Calcium signaling pathway_Homo sapiens_hsa040200.66733240
114Primary immunodeficiency_Homo sapiens_hsa053400.66291029
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64614159
116Propanoate metabolism_Homo sapiens_hsa006400.63489263
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61881169
118Fatty acid metabolism_Homo sapiens_hsa012120.61632303
119Lysosome_Homo sapiens_hsa041420.60989771
120Glycerolipid metabolism_Homo sapiens_hsa005610.59997435
121Phagosome_Homo sapiens_hsa041450.59709891
122Asthma_Homo sapiens_hsa053100.59556415
123Glucagon signaling pathway_Homo sapiens_hsa049220.59424238
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58909634
125Metabolic pathways_Homo sapiens_hsa011000.58688756
126Melanoma_Homo sapiens_hsa052180.58652781
127HIF-1 signaling pathway_Homo sapiens_hsa040660.58185886
128Tuberculosis_Homo sapiens_hsa051520.57312348
129Ovarian steroidogenesis_Homo sapiens_hsa049130.57254508
130Arginine and proline metabolism_Homo sapiens_hsa003300.56703583
131Fatty acid degradation_Homo sapiens_hsa000710.56657716
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55794705
133TGF-beta signaling pathway_Homo sapiens_hsa043500.54012309
134MicroRNAs in cancer_Homo sapiens_hsa052060.53871839
135Melanogenesis_Homo sapiens_hsa049160.53383869
136AMPK signaling pathway_Homo sapiens_hsa041520.53347664
137Steroid biosynthesis_Homo sapiens_hsa001000.52267811
138Renal cell carcinoma_Homo sapiens_hsa052110.50798387
139Insulin signaling pathway_Homo sapiens_hsa049100.50037704
140Ras signaling pathway_Homo sapiens_hsa040140.49576514
141Pancreatic cancer_Homo sapiens_hsa052120.49098326
142Purine metabolism_Homo sapiens_hsa002300.48495689
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47846761
144Hedgehog signaling pathway_Homo sapiens_hsa043400.47845005
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47725928
146Bile secretion_Homo sapiens_hsa049760.47289865
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46981844
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.46918222
149Pathways in cancer_Homo sapiens_hsa052000.46557847
150Osteoclast differentiation_Homo sapiens_hsa043800.46244783
151Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46125675
152Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45773919
153Hematopoietic cell lineage_Homo sapiens_hsa046400.45057022
154Dopaminergic synapse_Homo sapiens_hsa047280.44296236
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43639161
156Type I diabetes mellitus_Homo sapiens_hsa049400.42705507
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42525558
158Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42218786
159Long-term depression_Homo sapiens_hsa047300.41845721
160Platelet activation_Homo sapiens_hsa046110.41698009
161Rap1 signaling pathway_Homo sapiens_hsa040150.40731886
162Basal cell carcinoma_Homo sapiens_hsa052170.40423899
163Leishmaniasis_Homo sapiens_hsa051400.39988441
164Endometrial cancer_Homo sapiens_hsa052130.39416937
165Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39013462
166Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38359909
167Graft-versus-host disease_Homo sapiens_hsa053320.33124972
168Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31399195
169Pyrimidine metabolism_Homo sapiens_hsa002400.30792257
170Ribosome_Homo sapiens_hsa030100.30739651
171Rheumatoid arthritis_Homo sapiens_hsa053230.30322743
172cAMP signaling pathway_Homo sapiens_hsa040240.27961829
173NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27184633

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