PRSS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)8.31044476
2sterol catabolic process (GO:0016127)7.83836165
3cholesterol catabolic process (GO:0006707)7.83836165
4intestinal absorption (GO:0050892)7.74340526
5* cobalamin metabolic process (GO:0009235)7.62364470
6peptidyl-proline hydroxylation (GO:0019511)7.27292691
7negative regulation of digestive system process (GO:0060457)6.68143956
8glycolipid catabolic process (GO:0019377)6.59786390
9cysteine metabolic process (GO:0006534)6.46421137
10regulation of phospholipase A2 activity (GO:0032429)6.41697418
11membrane lipid catabolic process (GO:0046466)6.19123218
12proline biosynthetic process (GO:0006561)5.99778802
13COPI coating of Golgi vesicle (GO:0048205)5.82417927
14Golgi transport vesicle coating (GO:0048200)5.82417927
15protein hydroxylation (GO:0018126)5.62953021
16ceramide catabolic process (GO:0046514)5.57132669
17branched-chain amino acid catabolic process (GO:0009083)5.40079688
18valine metabolic process (GO:0006573)5.09882569
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.03014127
20cellular modified amino acid catabolic process (GO:0042219)4.96047860
21mitochondrial calcium ion transport (GO:0006851)4.82991112
22positive regulation of nuclease activity (GO:0032075)4.82006096
23serine family amino acid biosynthetic process (GO:0009070)4.78865174
24protein maturation by protein folding (GO:0022417)4.76583491
25branched-chain amino acid metabolic process (GO:0009081)4.75383407
26positive regulation of pseudopodium assembly (GO:0031274)4.65855291
27zinc ion transport (GO:0006829)4.57128861
28response to endoplasmic reticulum stress (GO:0034976)4.54471666
29homocysteine metabolic process (GO:0050667)4.50055939
30endoplasmic reticulum unfolded protein response (GO:0030968)4.49086720
31aspartate family amino acid catabolic process (GO:0009068)4.46389028
32phosphatidylinositol acyl-chain remodeling (GO:0036149)4.41772137
33regulation of nuclease activity (GO:0032069)4.38107237
34cellular response to unfolded protein (GO:0034620)4.35014612
35phosphatidylserine acyl-chain remodeling (GO:0036150)4.33764423
36maintenance of protein localization in organelle (GO:0072595)4.31554160
37leukotriene biosynthetic process (GO:0019370)4.27185631
38positive regulation of heat generation (GO:0031652)4.24962920
39regulation of metalloenzyme activity (GO:0048552)4.20743448
40regulation of guanylate cyclase activity (GO:0031282)4.19274572
41desmosome organization (GO:0002934)4.18426303
42cellular response to topologically incorrect protein (GO:0035967)4.15915964
43regulation of pseudopodium assembly (GO:0031272)4.15610438
44ER-nucleus signaling pathway (GO:0006984)4.14162701
45intestinal epithelial cell development (GO:0060576)4.14020355
464-hydroxyproline metabolic process (GO:0019471)4.13712457
47endocrine pancreas development (GO:0031018)4.09733675
48phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.08269563
49negative regulation of epidermis development (GO:0045683)4.05186840
50glutamine metabolic process (GO:0006541)4.03659568
51proline metabolic process (GO:0006560)4.01160858
52L-serine metabolic process (GO:0006563)3.96660265
53signal peptide processing (GO:0006465)3.95856274
54regulation of fever generation (GO:0031620)3.93999362
55steroid catabolic process (GO:0006706)3.91700232
56creatine metabolic process (GO:0006600)3.88860386
57regulation of cholesterol homeostasis (GO:2000188)3.87916877
58positive regulation of actin filament depolymerization (GO:0030836)3.73328028
59serine family amino acid metabolic process (GO:0009069)3.72714197
60L-phenylalanine catabolic process (GO:0006559)3.71962451
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71962451
62cellular response to zinc ion (GO:0071294)3.69513429
63regulation of keratinocyte differentiation (GO:0045616)3.68800833
64ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.66970257
65coenzyme catabolic process (GO:0009109)3.66085265
66neutrophil mediated immunity (GO:0002446)3.62249536
67icosanoid transport (GO:0071715)3.59010289
68fatty acid derivative transport (GO:1901571)3.59010289
69COPII vesicle coating (GO:0048208)3.57582596
70regulation of bile acid biosynthetic process (GO:0070857)3.57497757
71mitochondrion distribution (GO:0048311)3.54065518
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.50800445
73L-phenylalanine metabolic process (GO:0006558)3.50800445
74regulation of keratinocyte proliferation (GO:0010837)3.48742643
75response to unfolded protein (GO:0006986)3.47102943
76sphingolipid catabolic process (GO:0030149)3.46176618
77GDP-mannose metabolic process (GO:0019673)3.45441489
78regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.44998469
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.44689142
80positive regulation of guanylate cyclase activity (GO:0031284)3.44022103
81digestive system process (GO:0022600)3.42835768
82polarized epithelial cell differentiation (GO:0030859)3.42449945
83NADH metabolic process (GO:0006734)3.41769490
84actin filament depolymerization (GO:0030042)3.41616051
85angiotensin maturation (GO:0002003)3.36747236
86response to topologically incorrect protein (GO:0035966)3.36072094
87protein N-linked glycosylation via asparagine (GO:0018279)3.32475585
88glycine transport (GO:0015816)3.31264983
89peptidyl-asparagine modification (GO:0018196)3.31007914
90ER overload response (GO:0006983)3.30341886
91phosphatidylserine metabolic process (GO:0006658)3.29967115
92nucleotide-sugar biosynthetic process (GO:0009226)3.23776636
93antibacterial humoral response (GO:0019731)3.23428103
94cellular protein catabolic process (GO:0044257)3.23351562
95L-alpha-amino acid transmembrane transport (GO:1902475)3.21681589
96regulation of heat generation (GO:0031650)3.21463368
97glycine metabolic process (GO:0006544)3.20726994
98cell redox homeostasis (GO:0045454)3.17138541
99cellular glucuronidation (GO:0052695)3.16385899
100regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.14103087
101sterol transport (GO:0015918)3.10732540
102cholesterol transport (GO:0030301)3.10732540
103cellular response to cadmium ion (GO:0071276)3.10258415
104retinoic acid receptor signaling pathway (GO:0048384)3.06810729
105glucuronate metabolic process (GO:0019585)3.03003316
106uronic acid metabolic process (GO:0006063)3.03003316
107protein N-linked glycosylation (GO:0006487)3.02928376
108doxorubicin metabolic process (GO:0044598)3.02709214
109daunorubicin metabolic process (GO:0044597)3.02709214
110polyketide metabolic process (GO:0030638)3.02709214
111bile acid and bile salt transport (GO:0015721)3.02457738
112sulfur amino acid biosynthetic process (GO:0000097)3.02030120
113pancreas development (GO:0031016)3.01421655
114innate immune response in mucosa (GO:0002227)3.01340580
115regulation of oxidative stress-induced cell death (GO:1903201)2.99638998
116alditol phosphate metabolic process (GO:0052646)2.99638579
117alpha-amino acid biosynthetic process (GO:1901607)2.99628800
118antimicrobial humoral response (GO:0019730)2.98794722
119bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97645080
120phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.97444744
121calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96404472
122negative regulation of epidermal cell differentiation (GO:0045605)2.92819134
123negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.88558041
124icosanoid secretion (GO:0032309)2.88341504
125arachidonic acid secretion (GO:0050482)2.88341504
126activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.85371533
127regulation of cellular extravasation (GO:0002691)2.84486337
128one-carbon metabolic process (GO:0006730)2.84386219
129peptidyl-proline modification (GO:0018208)2.83584486
130negative regulation of cell fate commitment (GO:0010454)2.83175384
131phosphatidic acid biosynthetic process (GO:0006654)2.81393205
132phosphatidic acid metabolic process (GO:0046473)2.81393205
133sulfur amino acid catabolic process (GO:0000098)2.81120701
134glycoside metabolic process (GO:0016137)2.80825370
135positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.80428928
136renal system process involved in regulation of blood volume (GO:0001977)2.79086791
137regulation of cellular response to oxidative stress (GO:1900407)2.77002248
138biotin metabolic process (GO:0006768)2.74634387
139phosphatidylcholine acyl-chain remodeling (GO:0036151)2.73968015
140regulation of water loss via skin (GO:0033561)2.72586356
141maintenance of gastrointestinal epithelium (GO:0030277)2.72198426
142epoxygenase P450 pathway (GO:0019373)2.71612992
143* tetrapyrrole metabolic process (GO:0033013)2.70894624
144keratinization (GO:0031424)2.69392405
145hemidesmosome assembly (GO:0031581)2.69039954
146aminoglycoside antibiotic metabolic process (GO:0030647)2.68832647
147fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68577581
148hormone catabolic process (GO:0042447)2.65584489
149regulation of epidermal cell differentiation (GO:0045604)2.65133685
150nucleoside diphosphate biosynthetic process (GO:0009133)2.63720815
151skin morphogenesis (GO:0043589)2.62307121
152regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.62099534
153UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61790101
154establishment of skin barrier (GO:0061436)2.60746861
155phospholipid catabolic process (GO:0009395)2.58430987
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57567302
157response to gravity (GO:0009629)2.54018731
158regulation of triglyceride catabolic process (GO:0010896)2.51179179
159bile acid metabolic process (GO:0008206)2.48298310
160L-ascorbic acid metabolic process (GO:0019852)2.47414809
161negative regulation of protein tyrosine kinase activity (GO:0061099)2.47021118
162positive regulation of glycoprotein metabolic process (GO:1903020)2.46313816
163glutathione derivative metabolic process (GO:1901685)2.44705704
164glutathione derivative biosynthetic process (GO:1901687)2.44705704
165intestinal cholesterol absorption (GO:0030299)17.8147702
166exocrine pancreas development (GO:0031017)17.2908500
167* digestion (GO:0007586)13.9669543
168protein retention in ER lumen (GO:0006621)12.6723423
169maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.8538695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.88700378
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.42206520
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.26966898
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.91557135
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.88496324
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.65413896
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.94984563
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85367279
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.68519359
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.67694796
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.59484212
12ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.51847968
13* ERG_21242973_ChIP-ChIP_JURKAT_Human2.46131552
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.34595105
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.28322625
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.27546452
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27336525
18* GATA4_25053715_ChIP-Seq_YYC3_Human2.26465302
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21476301
20GATA6_25053715_ChIP-Seq_YYC3_Human2.07623898
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.02511468
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.92638999
23PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.89951128
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88154599
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88154599
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88154599
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.86463466
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.86463466
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81732793
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79596423
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.78514103
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78460711
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77449753
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75222699
35ZNF263_19887448_ChIP-Seq_K562_Human1.75214844
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73194608
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72472316
38* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71407538
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70660173
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.68790044
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63399194
42CREB1_26743006_Chip-Seq_LNCaP_Human1.62309418
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60606886
44LXR_22292898_ChIP-Seq_THP-1_Human1.60032210
45* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57662150
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.56528281
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53345632
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51052692
49GATA1_22025678_ChIP-Seq_K562_Human1.50191361
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48263100
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45157045
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44887993
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43537325
54P68_20966046_ChIP-Seq_HELA_Human1.43456949
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39904504
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34589597
57EGR1_19032775_ChIP-ChIP_M12_Human1.34446501
58CJUN_26792858_Chip-Seq_BT549_Human1.33909243
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32692388
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31675897
61* CHD1_26751641_Chip-Seq_LNCaP_Human1.31311092
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.29791406
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27707473
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26426010
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24691516
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.24129754
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23181209
68ERA_21632823_ChIP-Seq_H3396_Human1.22681850
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22551388
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21838102
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21448190
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.19037483
73CTCF_27219007_Chip-Seq_Bcells_Human1.16286078
74TAF2_19829295_ChIP-Seq_ESCs_Human1.16164793
75RACK7_27058665_Chip-Seq_MCF-7_Human1.15982118
76SA1_27219007_Chip-Seq_Bcells_Human1.15829341
77ATF3_27146783_Chip-Seq_COLON_Human1.14958804
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14047278
79CLOCK_20551151_ChIP-Seq_293T_Human1.11507661
80ESET_19884257_ChIP-Seq_ESCs_Mouse1.11368405
81KLF5_25053715_ChIP-Seq_YYC3_Human1.10826558
82* TP63_22573176_ChIP-Seq_HFKS_Human1.10387862
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10289574
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09840211
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09309656
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.08990384
87ERG_20517297_ChIP-Seq_VCAP_Human1.08231612
88ZNF274_21170338_ChIP-Seq_K562_Hela1.06211206
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.05870729
90FOXH1_21741376_ChIP-Seq_ESCs_Human1.05677565
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05137990
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.04881685
93OCT4_20526341_ChIP-Seq_ESCs_Human1.04688524
94ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03844138
95CBP_21632823_ChIP-Seq_H3396_Human1.03125964
96ETS1_21867929_ChIP-Seq_TH2_Mouse1.03086650
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02901776
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01779530
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.01515309
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01350090
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00953538
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00157631
103CTCF_20526341_ChIP-Seq_ESCs_Human0.98842208
104JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98700469
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98668887
106CSB_26484114_Chip-Seq_FIBROBLAST_Human0.98235901
107BCOR_27268052_Chip-Seq_Bcells_Human0.98063184
108CDX2_20551321_ChIP-Seq_CACO-2_Human0.98037538
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97980321
110* SOX2_20726797_ChIP-Seq_SW620_Human0.97403198
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97287825
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94742472
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.93937737
114P53_21459846_ChIP-Seq_SAOS-2_Human0.93461453
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.93359855
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93304802
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91159135
118KLF4_19829295_ChIP-Seq_ESCs_Human0.91121063
119KDM2B_26808549_Chip-Seq_K562_Human0.90918917
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90036451
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89963179
122P300_27268052_Chip-Seq_Bcells_Human0.89562143
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89542065
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.89382978
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88943904
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87919257
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87689032
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87368199
129BCL6_27268052_Chip-Seq_Bcells_Human0.87191622
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87062401
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85930546
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85907297
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.85751950
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85482146
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85181844
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84948865
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84586607
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84402046
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84340344
140CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83901251
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.83766554
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.83766554
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82622894
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82329327
145SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82231344
146* HNF4A_19822575_ChIP-Seq_HepG2_Human0.78928848
147SOX2_21211035_ChIP-Seq_LN229_Human0.77951878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.47092985
2MP0001666_abnormal_nutrient_absorption9.05814174
3MP0005220_abnormal_exocrine_pancreas6.75605269
4MP0005365_abnormal_bile_salt6.53313720
5MP0003868_abnormal_feces_composition5.23358395
6MP0005084_abnormal_gallbladder_morpholo5.13299486
7MP0005085_abnormal_gallbladder_physiolo3.40099848
8MP0002693_abnormal_pancreas_physiology2.82752106
9MP0009840_abnormal_foam_cell2.78248687
10MP0003959_abnormal_lean_body2.53180985
11MP0001664_abnormal_digestion2.48912617
12MP0002139_abnormal_hepatobiliary_system2.28034896
13MP0003705_abnormal_hypodermis_morpholog2.13059515
14MP0004019_abnormal_vitamin_homeostasis2.07885165
15MP0003191_abnormal_cellular_cholesterol2.03740794
16MP0001944_abnormal_pancreas_morphology1.99659518
17MP0002138_abnormal_hepatobiliary_system1.92800553
18MP0004264_abnormal_extraembryonic_tissu1.79289924
19MP0010352_gastrointestinal_tract_polyps1.72613641
20MP0005448_abnormal_energy_balance1.61378988
21MP0004233_abnormal_muscle_weight1.60623237
22MP0005501_abnormal_skin_physiology1.59269537
23MP0010234_abnormal_vibrissa_follicle1.51174962
24MP0010386_abnormal_urinary_bladder1.43096966
25MP0003638_abnormal_response/metabolism_1.42584817
26MP0004147_increased_porphyrin_level1.41318829
27MP0003252_abnormal_bile_duct1.38266354
28MP0002118_abnormal_lipid_homeostasis1.37150918
29MP0005166_decreased_susceptibility_to1.36460150
30MP0003950_abnormal_plasma_membrane1.34950365
31MP0002928_abnormal_bile_duct1.27245278
32MP0005451_abnormal_body_composition1.23796091
33MP0005332_abnormal_amino_acid1.22494286
34MP0003566_abnormal_cell_adhesion1.20613994
35MP0001765_abnormal_ion_homeostasis1.16874787
36MP0002277_abnormal_respiratory_mucosa1.16016991
37MP0001216_abnormal_epidermal_layer1.14013663
38MP0005257_abnormal_intraocular_pressure1.12461766
39MP0005165_increased_susceptibility_to1.12020769
40MP0003075_altered_response_to1.12013611
41MP0008875_abnormal_xenobiotic_pharmacok1.11541361
42MP0001756_abnormal_urination1.09275487
43MP0003183_abnormal_peptide_metabolism1.09116626
44MP0002078_abnormal_glucose_homeostasis1.04484870
45MP0005670_abnormal_white_adipose1.03774650
46MP0010155_abnormal_intestine_physiology1.03631143
47MP0005636_abnormal_mineral_homeostasis1.02884344
48MP0003283_abnormal_digestive_organ1.02788900
49MP0003879_abnormal_hair_cell0.99003829
50MP0009379_abnormal_foot_pigmentation0.98972755
51MP0000470_abnormal_stomach_morphology0.96595514
52MP0000003_abnormal_adipose_tissue0.95919358
53MP0000013_abnormal_adipose_tissue0.95614196
54MP0003453_abnormal_keratinocyte_physiol0.95429538
55MP0003866_abnormal_defecation0.92180528
56MP0008789_abnormal_olfactory_epithelium0.92097544
57MP0008004_abnormal_stomach_pH0.91609332
58MP0008438_abnormal_cutaneous_collagen0.89788171
59MP0005408_hypopigmentation0.89622613
60MP0010771_integument_phenotype0.85703566
61MP0000762_abnormal_tongue_morphology0.85331209
62MP0005409_darkened_coat_color0.84619401
63MP0000462_abnormal_digestive_system0.84059397
64MP0003315_abnormal_perineum_morphology0.81971724
65MP0001501_abnormal_sleep_pattern0.79283145
66MP0000477_abnormal_intestine_morphology0.78992195
67MP0005535_abnormal_body_temperature0.78787529
68MP0000467_abnormal_esophagus_morphology0.78661599
69MP0009643_abnormal_urine_homeostasis0.78490323
70MP0000538_abnormal_urinary_bladder0.78219687
71MP0005367_renal/urinary_system_phenotyp0.78178326
72MP0000516_abnormal_urinary_system0.78178326
73MP0005023_abnormal_wound_healing0.77642876
74MP0002136_abnormal_kidney_physiology0.74755214
75MP0000537_abnormal_urethra_morphology0.74339627
76MP0009384_cardiac_valve_regurgitation0.73978224
77MP0003953_abnormal_hormone_level0.73859134
78MP0005499_abnormal_olfactory_system0.72210222
79MP0005394_taste/olfaction_phenotype0.72210222
80MP0000613_abnormal_salivary_gland0.72132754
81MP0000490_abnormal_crypts_of0.71335854
82MP0006054_spinal_hemorrhage0.68005077
83MP0005058_abnormal_lysosome_morphology0.67627916
84MP0001873_stomach_inflammation0.67330311
85MP0010329_abnormal_lipoprotein_level0.67230093
86MP0000858_altered_metastatic_potential0.65313489
87MP0008961_abnormal_basal_metabolism0.63156349
88MP0002006_tumorigenesis0.63113777
89MP0005452_abnormal_adipose_tissue0.63087058
90MP0005360_urolithiasis0.62848306
91MP0003806_abnormal_nucleotide_metabolis0.62748120
92MP0000678_abnormal_parathyroid_gland0.60437005
93MP0004510_myositis0.58935416
94MP0010368_abnormal_lymphatic_system0.58567907
95MP0003045_fibrosis0.57869594
96MP0004782_abnormal_surfactant_physiolog0.57360785
97MP0000598_abnormal_liver_morphology0.56253178
98MP0000230_abnormal_systemic_arterial0.55508470
99MP0006036_abnormal_mitochondrial_physio0.54986528
100MP0005584_abnormal_enzyme/coenzyme_acti0.54879905
101MP0009780_abnormal_chondrocyte_physiolo0.51013288
102MP0005375_adipose_tissue_phenotype0.50574615
103MP0001663_abnormal_digestive_system0.49780496
104MP0000609_abnormal_liver_physiology0.49297427
105MP0001731_abnormal_postnatal_growth0.48785323
106MP0002089_abnormal_postnatal_growth/wei0.48160928
107MP0009765_abnormal_xenobiotic_induced0.47685140
108MP0004185_abnormal_adipocyte_glucose0.45223970
109MP0002098_abnormal_vibrissa_morphology0.43944284
110MP0003122_maternal_imprinting0.43281191
111MP0002796_impaired_skin_barrier0.42908780
112MP0003186_abnormal_redox_activity0.42632374
113MP0005381_digestive/alimentary_phenotyp0.42537002
114MP0001764_abnormal_homeostasis0.41281704
115MP0000750_abnormal_muscle_regeneration0.39687763
116MP0001845_abnormal_inflammatory_respons0.38545721
117MP0002060_abnormal_skin_morphology0.36917857
118MP0005319_abnormal_enzyme/_coenzyme0.36317589
119MP0005334_abnormal_fat_pad0.34666967
120MP0000955_abnormal_spinal_cord0.34526114
121MP0003329_amyloid_beta_deposits0.34424412
122MP0002069_abnormal_eating/drinking_beha0.34350967
123MP0003300_gastrointestinal_ulcer0.33662125
124MP0000377_abnormal_hair_follicle0.33606515
125MP0009703_decreased_birth_body0.32030600
126MP0000367_abnormal_coat/_hair0.31701948
127MP0009642_abnormal_blood_homeostasis0.30447044
128MP0010678_abnormal_skin_adnexa0.30004150
129MP0005187_abnormal_penis_morphology0.29440606
130MP0003123_paternal_imprinting0.29233358
131MP0003795_abnormal_bone_structure0.28968578
132MP0003172_abnormal_lysosome_physiology0.27292483
133MP0000371_diluted_coat_color0.27291680
134MP0004924_abnormal_behavior0.24672654
135MP0005386_behavior/neurological_phenoty0.24672654
136MP0002896_abnormal_bone_mineralization0.24168661
137MP0004043_abnormal_pH_regulation0.24132753
138MP0003943_abnormal_hepatobiliary_system0.24015659
139MP0003956_abnormal_body_size0.23830209
140MP0000647_abnormal_sebaceous_gland0.23740822
141MP0008872_abnormal_physiological_respon0.22237550
142MP0009333_abnormal_splenocyte_physiolog0.22178659
143MP0004272_abnormal_basement_membrane0.22095819
144MP0001348_abnormal_lacrimal_gland0.21605562
145MP0009672_abnormal_birth_weight0.20947719
146MP0002876_abnormal_thyroid_physiology0.20835105
147MP0000778_abnormal_nervous_system0.19669819

Predicted human phenotypes

RankGene SetZ-score
1Fat malabsorption (HP:0002630)8.67221197
2Exocrine pancreatic insufficiency (HP:0001738)7.80524086
3Hypoproteinemia (HP:0003075)7.14417375
4Gout (HP:0001997)6.04450155
5Short chin (HP:0000331)5.99403656
6Decreased subcutaneous fat (HP:0001002)5.52656523
7Type I diabetes mellitus (HP:0100651)5.17272370
8Abnormality of subcutaneous fat tissue (HP:0001001)4.96316327
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.82779787
10Maternal diabetes (HP:0009800)4.70525968
11Pancreatitis (HP:0001733)4.61537181
12Abnormal pancreas size (HP:0012094)4.43744858
13Abnormality of the intrinsic pathway (HP:0010989)4.29778829
14Vascular calcification (HP:0004934)4.11639349
15Hypoplasia of the pons (HP:0012110)4.00793595
16Ketoacidosis (HP:0001993)3.83377104
17Ketosis (HP:0001946)3.82577459
18Abnormality of the pons (HP:0007361)3.71859984
19Premature skin wrinkling (HP:0100678)3.67599140
20Joint stiffness (HP:0001387)3.67486354
21Abnormality of proline metabolism (HP:0010907)3.65669908
22Hydroxyprolinuria (HP:0003080)3.65669908
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.64453732
24Cardiovascular calcification (HP:0011915)3.64318245
25Abnormality of endocrine pancreas physiology (HP:0012093)3.59859221
26Abnormality of the pancreatic islet cells (HP:0006476)3.59859221
27Ileus (HP:0002595)3.45064862
28Malnutrition (HP:0004395)3.24817171
29Cortical dysplasia (HP:0002539)3.20650712
30Tubulointerstitial fibrosis (HP:0005576)3.08249580
31Hypoglycemic coma (HP:0001325)3.00484891
32Tubulointerstitial nephritis (HP:0001970)2.97901432
33Late onset (HP:0003584)2.95059234
34Axonal loss (HP:0003447)2.92865418
35Hyperactive renin-angiotensin system (HP:0000841)2.91956393
36Alopecia of scalp (HP:0002293)2.86246133
37Carpal bone hypoplasia (HP:0001498)2.78114425
38Hyperglycinemia (HP:0002154)2.75767567
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74946027
40Optic nerve hypoplasia (HP:0000609)2.71276261
41Abnormality of the common coagulation pathway (HP:0010990)2.70912952
42Long foot (HP:0001833)2.68143928
43Delayed CNS myelination (HP:0002188)2.67749864
44Xanthomatosis (HP:0000991)2.66882704
45Hypoglycemic seizures (HP:0002173)2.65415176
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.64633752
47Congenital glaucoma (HP:0001087)2.61479722
48Increased purine levels (HP:0004368)2.61040606
49Hyperuricemia (HP:0002149)2.61040606
50Plantar hyperkeratosis (HP:0007556)2.59328694
51Palmoplantar hyperkeratosis (HP:0000972)2.59082524
52Abnormality of vitamin B metabolism (HP:0004340)2.58844306
53Glycosuria (HP:0003076)2.58628435
54Abnormality of urine glucose concentration (HP:0011016)2.58628435
55Prenatal maternal abnormality (HP:0002686)2.57878153
56Amyloidosis (HP:0011034)2.56862017
57Abnormal hair laboratory examination (HP:0003328)2.52017266
58Hyperinsulinemic hypoglycemia (HP:0000825)2.50789697
59Congenital ichthyosiform erythroderma (HP:0007431)2.49106304
60Reduced subcutaneous adipose tissue (HP:0003758)2.45319001
61Growth hormone excess (HP:0000845)2.42067337
62Insulin resistance (HP:0000855)2.40768721
63Abnormality of vitamin metabolism (HP:0100508)2.39683687
64Villous atrophy (HP:0011473)2.37391786
65Abnormality of small intestinal villus morphology (HP:0011472)2.37391786
66Tetraparesis (HP:0002273)2.36102809
67Abnormality of glycine metabolism (HP:0010895)2.33773896
68Abnormality of serine family amino acid metabolism (HP:0010894)2.33773896
69Palmar hyperkeratosis (HP:0010765)2.31984162
70Onycholysis (HP:0001806)2.30989084
71Abnormal tarsal ossification (HP:0008369)2.30779534
72Hyperglycinuria (HP:0003108)2.29825600
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29279473
74Fatigue (HP:0012378)2.29257506
75Glucose intolerance (HP:0000833)2.29162180
76Pili torti (HP:0003777)2.26944875
77Abnormal protein glycosylation (HP:0012346)2.26004285
78Abnormal glycosylation (HP:0012345)2.26004285
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26004285
80Abnormal protein N-linked glycosylation (HP:0012347)2.26004285
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.25874526
82Pectus carinatum (HP:0000768)2.25051324
83Abnormality of the pleura (HP:0002103)2.23236192
84Abnormal glucose tolerance (HP:0001952)2.16406181
85Progressive muscle weakness (HP:0003323)2.13085706
86Large for gestational age (HP:0001520)2.13008634
87Intrahepatic cholestasis (HP:0001406)2.12996028
88Short nail (HP:0001799)2.12669151
89Hypoplasia of the odontoid process (HP:0003311)2.12552708
90Decreased circulating renin level (HP:0003351)2.12108738
91Abnormality of the distal phalanges of the toes (HP:0010182)2.11983702
92Hyperglycemia (HP:0003074)2.11417693
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.09930490
94Osteolytic defects of the hand bones (HP:0009699)2.09930490
95Esophageal varix (HP:0002040)2.09648970
96Dysostosis multiplex (HP:0000943)2.09262978
97Proximal tubulopathy (HP:0000114)2.08578073
98Distal upper limb amyotrophy (HP:0007149)2.08008785
99Upper limb amyotrophy (HP:0009129)2.08008785
100Acanthosis nigricans (HP:0000956)2.05017874
101Abdominal distention (HP:0003270)2.03870141
102Type II lissencephaly (HP:0007260)2.02554088
103Ventricular fibrillation (HP:0001663)2.01794896
104Confusion (HP:0001289)2.00996789
105Steatorrhea (HP:0002570)10.7125674
106Hypobetalipoproteinemia (HP:0003563)1.99188996
107Abnormality of renin-angiotensin system (HP:0000847)1.98239500
108Insulin-resistant diabetes mellitus (HP:0000831)1.97666550
109Vacuolated lymphocytes (HP:0001922)1.97600926
110Small epiphyses (HP:0010585)1.96496357
111Hand muscle atrophy (HP:0009130)1.95515803
112Abnormality of methionine metabolism (HP:0010901)1.94386322
113Enlarged penis (HP:0000040)1.93674412
114Alkalosis (HP:0001948)1.93584472
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92770415
116Sparse eyelashes (HP:0000653)1.91244585
117Acute hepatic failure (HP:0006554)1.91016002
118Hyperammonemia (HP:0001987)1.90851650
119Dehydration (HP:0001944)1.90697394
120Opisthotonus (HP:0002179)1.90499216
121Cortical visual impairment (HP:0100704)1.89836400
122Woolly hair (HP:0002224)1.89106196
123Hypsarrhythmia (HP:0002521)1.88969536
124Popliteal pterygium (HP:0009756)1.88539591
125Palpitations (HP:0001962)1.88412168
126Methylmalonic aciduria (HP:0012120)1.86982197
127Abnormality of nail color (HP:0100643)1.86882360
128Hypoplasia of the uterus (HP:0000013)1.86608787
129Distal lower limb muscle weakness (HP:0009053)1.86509465
130Homocystinuria (HP:0002156)1.86391422
131Abnormality of homocysteine metabolism (HP:0010919)1.86391422
132Abnormality of the Achilles tendon (HP:0005109)1.85223654
133Right ventricular cardiomyopathy (HP:0011663)1.85097427
134Myocardial infarction (HP:0001658)1.85087872
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85000586
136Focal segmental glomerulosclerosis (HP:0000097)1.84936857
137Ankyloglossia (HP:0010296)1.84764000
138Type I transferrin isoform profile (HP:0003642)1.84303682
139Adrenal hypoplasia (HP:0000835)1.84301997
140Infantile muscular hypotonia (HP:0008947)1.82617287
141Metabolic alkalosis (HP:0200114)1.82087911
142Fragile nails (HP:0001808)1.79919066
143Milia (HP:0001056)1.78902980
144Hyperphosphaturia (HP:0003109)1.78370557
145Hepatocellular necrosis (HP:0001404)1.78342827
146EEG with generalized epileptiform discharges (HP:0011198)1.77932084
147Hepatic necrosis (HP:0002605)1.77431869
148Prolonged neonatal jaundice (HP:0006579)1.77199075
149Pancreatic islet-cell hyperplasia (HP:0004510)1.77129376
150Oral leukoplakia (HP:0002745)1.75696409
151Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75232766
152Tubular atrophy (HP:0000092)1.74692665
153Hypokinesia (HP:0002375)1.74626914
154Hypolipoproteinemia (HP:0010981)1.74453080
155Hyperparathyroidism (HP:0000843)1.74284819
156Congenital, generalized hypertrichosis (HP:0004540)1.73750676
157Multiple lipomas (HP:0001012)1.73750001
158Spastic diplegia (HP:0001264)1.73238188
159Tubulointerstitial abnormality (HP:0001969)1.72970255
160Distal lower limb amyotrophy (HP:0008944)1.72949442
161Large hands (HP:0001176)1.72476714
162Atrophic scars (HP:0001075)1.72020038
163Hyperphosphatemia (HP:0002905)1.71632626
164Congenital sensorineural hearing impairment (HP:0008527)1.71593015
165Deep venous thrombosis (HP:0002625)1.70601582
166Tongue fasciculations (HP:0001308)1.70538200
167Hypotension (HP:0002615)1.69706796
168Renal tubular acidosis (HP:0001947)1.69199091
169Vertebral compression fractures (HP:0002953)1.69184419
170Epileptiform EEG discharges (HP:0011182)1.69016608
171Abnormality of the odontoid process (HP:0003310)1.68863180
172Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68404885
173Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.68091937
174Reduced antithrombin III activity (HP:0001976)1.67765356
175Abnormality of purine metabolism (HP:0004352)1.65732451
176Barrel-shaped chest (HP:0001552)1.65342192
177Anal atresia (HP:0002023)1.62309918
178Abnormality of the renal cortex (HP:0011035)1.62181367
179Athetosis (HP:0002305)1.61887907
180Abnormal foot bone ossification (HP:0010675)1.61732820
181Symptomatic seizures (HP:0011145)1.61073344
182Prolonged QT interval (HP:0001657)1.60238216
183Absent eyelashes (HP:0000561)1.57374478
184Conjugated hyperbilirubinemia (HP:0002908)1.57317581
185Severe short stature (HP:0003510)1.57163698
186Redundant skin (HP:0001582)1.56114233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.68168469
2EPHA27.56567704
3MST1R6.24133069
4LMTK25.49481741
5ERN15.42472810
6MAP2K24.27018944
7TRIB34.16095695
8EIF2AK34.04931174
9PKN23.70938462
10TESK13.41952734
11INSRR2.86367512
12MAP3K122.70532537
13MST42.48395302
14TESK22.41004979
15LIMK12.35964661
16EPHB22.18137093
17FRK1.90967474
18MAPKAPK31.83152850
19MAPK151.77042289
20MAP3K31.75232763
21MAP2K11.75009145
22PAK21.66150592
23ZAP701.64798113
24ARAF1.57093466
25NME11.54667512
26PRKG21.52168805
27PAK41.50119954
28PHKG21.49629864
29PHKG11.49629864
30PIM21.49545104
31WNK41.44132019
32SCYL21.43531508
33ACVR1B1.39301894
34NME21.38844850
35PTK61.35651268
36TAOK31.35155289
37MYLK1.29045849
38DYRK1A1.26315669
39VRK21.26082108
40IRAK31.25844370
41RPS6KB21.25666041
42DAPK11.18424659
43EEF2K1.15998227
44CAMKK11.10303111
45FLT31.08009753
46PDGFRB0.97647837
47ABL20.97335637
48SIK10.92073090
49DAPK20.90944135
50STK240.87533598
51BMX0.86939370
52EPHA40.86508205
53ERBB40.83630367
54PTK2B0.80468769
55PIK3CG0.79115581
56MAP3K20.77967297
57RET0.77313001
58MTOR0.77129348
59TIE10.74282700
60PIK3CA0.69598416
61RIPK10.67855563
62PASK0.67328692
63MAP2K70.66275060
64LATS10.65150434
65MAP2K60.63772519
66GRK10.63589296
67LRRK20.62964908
68KSR20.62734921
69OXSR10.62402506
70PRKD30.61828096
71DYRK1B0.61278397
72HIPK20.59211883
73STK100.59191157
74ILK0.58622040
75MAP3K110.58391034
76PRKCZ0.58117680
77PRKCI0.57983731
78FGFR40.57555168
79PRKCH0.56852043
80STK390.56333412
81CAMKK20.54818498
82TAOK20.53903784
83STK380.52920062
84PDPK10.51312421
85PDGFRA0.49087520
86CDK80.46780897
87NTRK10.45800663
88STK160.45037412
89MAP3K90.44102242
90RPS6KB10.43834279
91DAPK30.42202095
92FER0.42133632
93TGFBR20.41279161
94PRPF4B0.41233306
95MAPK120.40434840
96PDK10.40189055
97EPHB10.40082748
98PTK20.39403380
99ROCK10.38933165
100PDK20.36654205
101MAPK30.35902498
102MAP3K10.35723266
103PRKCE0.35216844
104PRKACB0.34846317
105CAMK2G0.34405723
106MAP3K70.34333147
107CAMK2D0.33856714
108NTRK30.33633461
109DDR20.33386346
110TYRO30.32489932
111TRPM70.32402724
112NEK10.30614400
113ROCK20.30608281
114ADRBK10.30590435
115IRAK20.29918157
116STK38L0.29783117
117MAP4K20.28056299
118PINK10.28050914
119MOS0.28020166
120RPS6KA10.27324429
121JAK20.27067631
122CAMK1D0.26124057
123BRAF0.25328577
124TAOK10.24818402
125EIF2AK10.24805575
126MET0.23292920
127PRKD10.22649984
128PAK10.21831499
129MAPK10.20927222
130ERBB30.18999332
131ABL10.18919939
132MATK0.17169002
133SRC0.16796677
134TBK10.16660164
135CSNK1E0.16122585
136DYRK20.15978286
137PRKCA0.15927194
138MAPK110.14940190
139KDR0.14645853
140GSK3A0.14488146
141IGF1R0.14392483
142AKT10.14337900
143NEK60.14325422
144ICK0.13516039
145IRAK40.13176880
146MAP2K40.12643548
147CDK50.10728647
148RPS6KA30.10550479
149PAK60.10412204
150CSNK1A10.10304867
151EPHA30.10087673
152CDK190.10059497
153CSNK1G30.10044742
154MAP3K80.09465716
155MAP3K100.08855163
156ERBB20.08327205
157GRK50.07991873
158CDK40.07958386
159PRKACA0.07418689
160CAMK1G0.07188412

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.48802811
2Fat digestion and absorption_Homo sapiens_hsa049756.05781953
3* Protein digestion and absorption_Homo sapiens_hsa049745.63993166
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.70955494
5Protein export_Homo sapiens_hsa030603.31481613
6Glycerolipid metabolism_Homo sapiens_hsa005612.98242635
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.78670894
8Folate biosynthesis_Homo sapiens_hsa007902.77164451
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55592704
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21514509
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05144793
12Steroid biosynthesis_Homo sapiens_hsa001001.82798404
13Propanoate metabolism_Homo sapiens_hsa006401.71900803
14Vitamin digestion and absorption_Homo sapiens_hsa049771.71346639
15Mineral absorption_Homo sapiens_hsa049781.70399142
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56389804
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51834747
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40876139
19Renin-angiotensin system_Homo sapiens_hsa046141.37845249
20Chemical carcinogenesis_Homo sapiens_hsa052041.33351412
21Galactose metabolism_Homo sapiens_hsa000521.26618767
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.19438286
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.16960373
24Arginine and proline metabolism_Homo sapiens_hsa003301.15554620
25Retinol metabolism_Homo sapiens_hsa008301.14466558
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12972376
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10610711
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08901003
29N-Glycan biosynthesis_Homo sapiens_hsa005101.05831494
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05281926
31Biosynthesis of amino acids_Homo sapiens_hsa012300.99577093
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97659142
33Linoleic acid metabolism_Homo sapiens_hsa005910.91628997
34Caffeine metabolism_Homo sapiens_hsa002320.91449197
35Selenocompound metabolism_Homo sapiens_hsa004500.91169861
36Fatty acid elongation_Homo sapiens_hsa000620.89019402
37Proteasome_Homo sapiens_hsa030500.87038395
38Notch signaling pathway_Homo sapiens_hsa043300.86697774
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86566021
40Insulin secretion_Homo sapiens_hsa049110.84308887
41Starch and sucrose metabolism_Homo sapiens_hsa005000.83185583
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82799643
43Other glycan degradation_Homo sapiens_hsa005110.81765273
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80678250
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78606224
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76485247
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.73403935
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71421074
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69782069
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68145245
51Oxidative phosphorylation_Homo sapiens_hsa001900.66565911
52PPAR signaling pathway_Homo sapiens_hsa033200.66450221
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66266326
54Vibrio cholerae infection_Homo sapiens_hsa051100.65719433
55One carbon pool by folate_Homo sapiens_hsa006700.62946380
56Sulfur metabolism_Homo sapiens_hsa009200.61260425
57Phenylalanine metabolism_Homo sapiens_hsa003600.59485727
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.58461335
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58329661
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57887388
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57659472
62Vitamin B6 metabolism_Homo sapiens_hsa007500.57644377
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57161306
64beta-Alanine metabolism_Homo sapiens_hsa004100.56727939
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54341784
66Sphingolipid metabolism_Homo sapiens_hsa006000.53977306
67Pentose phosphate pathway_Homo sapiens_hsa000300.52702492
68Fatty acid degradation_Homo sapiens_hsa000710.50855911
69* Influenza A_Homo sapiens_hsa051640.50191683
70Complement and coagulation cascades_Homo sapiens_hsa046100.47868098
71Pyruvate metabolism_Homo sapiens_hsa006200.46833868
72Salivary secretion_Homo sapiens_hsa049700.45462279
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45419321
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43209898
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42576658
76Tryptophan metabolism_Homo sapiens_hsa003800.42238709
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42049678
78Arginine biosynthesis_Homo sapiens_hsa002200.41533767
79Tyrosine metabolism_Homo sapiens_hsa003500.39638400
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38818154
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36496726
82Tight junction_Homo sapiens_hsa045300.35180490
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34658337
84Sulfur relay system_Homo sapiens_hsa041220.32780987
85Glutathione metabolism_Homo sapiens_hsa004800.32457376
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30832240
87Legionellosis_Homo sapiens_hsa051340.30312638
88Carbon metabolism_Homo sapiens_hsa012000.29489441
89Lysosome_Homo sapiens_hsa041420.28504914
90Circadian rhythm_Homo sapiens_hsa047100.27709085
91Endometrial cancer_Homo sapiens_hsa052130.27482521
92Metabolic pathways_Homo sapiens_hsa011000.25562647
93Nitrogen metabolism_Homo sapiens_hsa009100.25211689
94VEGF signaling pathway_Homo sapiens_hsa043700.23671952
95Arachidonic acid metabolism_Homo sapiens_hsa005900.22093255
96Alzheimers disease_Homo sapiens_hsa050100.21398836
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21186323
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21122953
99* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19332579
100Parkinsons disease_Homo sapiens_hsa050120.18866186
101Huntingtons disease_Homo sapiens_hsa050160.18289989
102Calcium signaling pathway_Homo sapiens_hsa040200.17356433
103Ether lipid metabolism_Homo sapiens_hsa005650.15543660
104Fatty acid metabolism_Homo sapiens_hsa012120.15372981
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.14964049
106Synaptic vesicle cycle_Homo sapiens_hsa047210.14958281
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14956199
108Fructose and mannose metabolism_Homo sapiens_hsa000510.14756501
109Prostate cancer_Homo sapiens_hsa052150.12974181
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.12706704
111Non-small cell lung cancer_Homo sapiens_hsa052230.12226711
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09283128
113Hepatitis C_Homo sapiens_hsa051600.08716595
114Cocaine addiction_Homo sapiens_hsa050300.08656692
115Bile secretion_Homo sapiens_hsa049760.07664780
116Insulin resistance_Homo sapiens_hsa049310.07570520
117Bladder cancer_Homo sapiens_hsa052190.07565295
118Pyrimidine metabolism_Homo sapiens_hsa002400.06609802
119Butanoate metabolism_Homo sapiens_hsa006500.06044302
120mTOR signaling pathway_Homo sapiens_hsa041500.05991647
121Glucagon signaling pathway_Homo sapiens_hsa049220.05480823
122Endocytosis_Homo sapiens_hsa041440.05398802
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.04961917
124Histidine metabolism_Homo sapiens_hsa003400.04710453
125Pancreatic cancer_Homo sapiens_hsa052120.03937481
126Thyroid hormone synthesis_Homo sapiens_hsa049180.03278749
127Lysine degradation_Homo sapiens_hsa003100.03086564
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.02456403
129Peroxisome_Homo sapiens_hsa041460.02404748
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.02404683
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01992147
132Type I diabetes mellitus_Homo sapiens_hsa049400.01578004
133Viral myocarditis_Homo sapiens_hsa054160.01391983
134Estrogen signaling pathway_Homo sapiens_hsa049150.00907674
135Regulation of autophagy_Homo sapiens_hsa041400.00866565
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.00196586
137Insulin signaling pathway_Homo sapiens_hsa04910-0.0184578
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0142427
139Toxoplasmosis_Homo sapiens_hsa05145-0.0059150

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