PRSS33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to cilium (GO:0061512)8.51204538
2negative regulation of cell killing (GO:0031342)7.26333454
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.26333454
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.17592087
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.61967038
6modulation by symbiont of host defense response (GO:0052031)6.45793240
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.45793240
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.45793240
9positive regulation by organism of defense response of other organism involved in symbiotic interact6.45793240
10modulation by symbiont of host immune response (GO:0052553)6.45793240
11positive regulation by symbiont of host defense response (GO:0052509)6.45793240
12tachykinin receptor signaling pathway (GO:0007217)6.35005786
13antigen processing and presentation of endogenous antigen (GO:0019883)6.34399352
14positive regulation of digestive system process (GO:0060456)6.27358028
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.96960266
16one-carbon compound transport (GO:0019755)5.58986425
17positive regulation of gamma-delta T cell activation (GO:0046645)5.53186172
18regulation of cholesterol biosynthetic process (GO:0045540)5.40887298
19detection of other organism (GO:0098543)5.34244964
20detection of bacterium (GO:0016045)5.23854906
21neutrophil activation involved in immune response (GO:0002283)5.22612684
22ethanol oxidation (GO:0006069)5.21930202
23macrophage activation involved in immune response (GO:0002281)4.96845846
24antibacterial humoral response (GO:0019731)4.95796579
25regulation of B cell receptor signaling pathway (GO:0050855)4.85807774
26leukocyte aggregation (GO:0070486)4.68918537
27response to interleukin-15 (GO:0070672)4.63551399
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.59349051
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.58681872
30antimicrobial humoral response (GO:0019730)4.57918660
31respiratory burst (GO:0045730)4.51599101
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.48520190
33detection of external biotic stimulus (GO:0098581)4.43594715
34leukocyte migration involved in inflammatory response (GO:0002523)4.41614489
35regulation of sodium ion transmembrane transport (GO:1902305)4.39637006
36neutrophil activation (GO:0042119)4.35118874
37cellular response to interleukin-15 (GO:0071350)4.34289400
38protein insertion into membrane (GO:0051205)4.24629301
39regulation of interferon-beta biosynthetic process (GO:0045357)4.23597501
40activation of protein kinase A activity (GO:0034199)4.23206658
41cellular glucuronidation (GO:0052695)4.17958632
42response to host immune response (GO:0052572)4.14862887
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.14862887
44response to peptidoglycan (GO:0032494)4.14012873
45cellular extravasation (GO:0045123)4.12686295
46uronic acid metabolic process (GO:0006063)4.11740999
47glucuronate metabolic process (GO:0019585)4.11740999
48negative regulation of phagocytosis (GO:0050765)4.10335543
49epoxygenase P450 pathway (GO:0019373)4.09020365
50detection of molecule of bacterial origin (GO:0032490)3.98663642
51negative regulation of cytosolic calcium ion concentration (GO:0051481)3.98410979
52negative regulation of interleukin-12 production (GO:0032695)3.98025827
53regulation of gamma-delta T cell activation (GO:0046643)3.97595794
54ethanol metabolic process (GO:0006067)3.94550604
55neutrophil mediated immunity (GO:0002446)3.92726876
56negative regulation of leukocyte mediated immunity (GO:0002704)3.92376943
57regulation of cardioblast proliferation (GO:0003264)3.87241095
58regulation of secondary heart field cardioblast proliferation (GO:0003266)3.87241095
59granulocyte activation (GO:0036230)3.86216326
60response to host (GO:0075136)3.85101892
61response to host defenses (GO:0052200)3.85101892
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.85101892
63antigen processing and presentation via MHC class Ib (GO:0002475)3.83662287
64regulation of cilium movement (GO:0003352)3.82701214
65detection of biotic stimulus (GO:0009595)3.81541162
66microglial cell activation (GO:0001774)3.78016713
67regulation of mast cell degranulation (GO:0043304)3.75208884
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.69551556
69myeloid cell activation involved in immune response (GO:0002275)3.68169366
70regulation of sodium ion transmembrane transporter activity (GO:2000649)3.67649521
71camera-type eye morphogenesis (GO:0048593)3.66760672
72hormone catabolic process (GO:0042447)3.64499359
73regulation of T cell tolerance induction (GO:0002664)3.64315718
74positive regulation of mast cell activation (GO:0033005)3.63513121
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.62476916
76cellular potassium ion homeostasis (GO:0030007)3.61817722
77regulation of gamma-delta T cell differentiation (GO:0045586)3.60227405
78exogenous drug catabolic process (GO:0042738)3.59782225
79sterol catabolic process (GO:0016127)3.59296957
80cholesterol catabolic process (GO:0006707)3.59296957
81negative regulation of astrocyte differentiation (GO:0048712)3.58217413
82negative regulation of T cell mediated immunity (GO:0002710)3.57904151
83lateral ventricle development (GO:0021670)3.56318451
84immunoglobulin mediated immune response (GO:0016064)3.55633993
85regulation of sodium ion transport (GO:0002028)3.52285907
86regulation of myeloid leukocyte mediated immunity (GO:0002886)3.45513927
87macrophage activation (GO:0042116)3.45480833
88regulation of mast cell activation involved in immune response (GO:0033006)3.43792764
89leukocyte degranulation (GO:0043299)3.40126720
90mating behavior (GO:0007617)3.38076916
91positive regulation of T cell mediated cytotoxicity (GO:0001916)3.37458483
92flavonoid metabolic process (GO:0009812)3.35985515
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33919378
94regulation of natural killer cell mediated immunity (GO:0002715)3.33919378
95positive regulation of hormone biosynthetic process (GO:0046886)3.31495677
96regulation of leukocyte degranulation (GO:0043300)3.30053709
97regulation of T cell mediated cytotoxicity (GO:0001914)3.30035408
98renal absorption (GO:0070293)3.29380888
99B cell receptor signaling pathway (GO:0050853)3.28788883
100regulation of tolerance induction (GO:0002643)3.28248659
101myeloid leukocyte mediated immunity (GO:0002444)3.26300018
102production of molecular mediator involved in inflammatory response (GO:0002532)3.24916348
103negative T cell selection (GO:0043383)3.23424760
104tolerance induction (GO:0002507)3.23174789
105regulation of heart rate by cardiac conduction (GO:0086091)3.22846442
106signal complex assembly (GO:0007172)3.22785494
107regulation of hippo signaling (GO:0035330)3.22554644
108regulation of cholesterol metabolic process (GO:0090181)3.20537887
109cAMP biosynthetic process (GO:0006171)3.19272937
110gas transport (GO:0015669)3.18373767
111steroid catabolic process (GO:0006706)3.16870228
112negative thymic T cell selection (GO:0045060)3.16774948
113regulation of mast cell activation (GO:0033003)3.15745670
114negative regulation of microtubule polymerization (GO:0031115)3.14478999
115dendritic cell migration (GO:0036336)3.10637802
116regulation of B cell differentiation (GO:0045577)3.08065221
117positive thymic T cell selection (GO:0045059)3.07204219
118potassium ion homeostasis (GO:0055075)3.04880629
119negative regulation of transcription regulatory region DNA binding (GO:2000678)3.04655863
120type I interferon signaling pathway (GO:0060337)3.04591702
121cellular response to type I interferon (GO:0071357)3.04591702
122negative regulation of innate immune response (GO:0045824)3.03880183
123negative regulation of glycoprotein biosynthetic process (GO:0010561)3.03870531
124response to type I interferon (GO:0034340)3.02827772
125activated T cell proliferation (GO:0050798)3.00739063
126sensory perception of smell (GO:0007608)24.2242409
127positive regulation of mast cell activation involved in immune response (GO:0033008)2.99910546
128positive regulation of mast cell degranulation (GO:0043306)2.99910546
129layer formation in cerebral cortex (GO:0021819)2.97578070
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97095189
131regulation of regulated secretory pathway (GO:1903305)2.96973507
132negative regulation of interleukin-6 production (GO:0032715)2.96721588
133ovulation cycle (GO:0042698)2.96693850
134regulation of alpha-beta T cell proliferation (GO:0046640)2.95484583
135drug catabolic process (GO:0042737)2.94611975
136dendritic cell chemotaxis (GO:0002407)2.93781528
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93621380
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91741064
139axoneme assembly (GO:0035082)2.90363107
140water transport (GO:0006833)2.89645907
141negative regulation of alpha-beta T cell activation (GO:0046636)2.89434640
142negative regulation of sodium ion transport (GO:0010766)2.84991756
143atrial cardiac muscle cell action potential (GO:0086014)2.84773894
144regulation of regulatory T cell differentiation (GO:0045589)2.84767242
145alkaloid metabolic process (GO:0009820)2.84452508
146T cell selection (GO:0045058)2.83557484
147defense response to protozoan (GO:0042832)2.83366754
148sodium ion export (GO:0071436)2.83184685
149negative regulation of type 2 immune response (GO:0002829)2.83068119
150response to muramyl dipeptide (GO:0032495)2.81002649
151cellular defense response (GO:0006968)2.80613461
152T cell homeostasis (GO:0043029)2.80216324
153T cell migration (GO:0072678)2.77313884
154negative regulation of interleukin-1 production (GO:0032692)2.76740146
155glial cell proliferation (GO:0014009)2.76372498
156dopamine receptor signaling pathway (GO:0007212)2.76044270
157negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75819941
158regulation of T-helper 2 cell differentiation (GO:0045628)2.75567967
159water-soluble vitamin biosynthetic process (GO:0042364)2.74823804
160positive regulation of steroid biosynthetic process (GO:0010893)2.74047016
161cardiac conduction (GO:0061337)2.73908040
162cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.69231393
163epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68258591
164primary alcohol catabolic process (GO:0034310)2.66831683
165regulation of steroid hormone biosynthetic process (GO:0090030)2.66300529
166response to vitamin A (GO:0033189)2.65823726
167omega-hydroxylase P450 pathway (GO:0097267)2.64099039
168relaxation of cardiac muscle (GO:0055119)2.63743372
169membrane repolarization during action potential (GO:0086011)2.61838718
170regulation of microtubule-based movement (GO:0060632)2.57450256
171ectoderm development (GO:0007398)2.56568310
172negative regulation of lipase activity (GO:0060192)2.56467059
173cellular response to glucagon stimulus (GO:0071377)2.55662648
174cilium morphogenesis (GO:0060271)2.55185975
175brain morphogenesis (GO:0048854)2.55121320
176fluid transport (GO:0042044)2.52149343
177sulfur amino acid catabolic process (GO:0000098)2.51979630
178cell communication involved in cardiac conduction (GO:0086065)2.50214240
179bile acid biosynthetic process (GO:0006699)2.50010023
180positive regulation of hormone metabolic process (GO:0032352)2.49609236
181middle ear morphogenesis (GO:0042474)2.47273808
182regulation of digestive system process (GO:0044058)2.46856804
183striatum development (GO:0021756)2.44012930
184establishment of apical/basal cell polarity (GO:0035089)2.42832919
185synaptic vesicle maturation (GO:0016188)2.41525743
186aorta morphogenesis (GO:0035909)2.41426728
187response to caffeine (GO:0031000)2.40298116
188hyperosmotic salinity response (GO:0042538)2.35934461
189cranial nerve morphogenesis (GO:0021602)2.34568866
190nephron tubule formation (GO:0072079)2.32926021
191calcium-mediated signaling using intracellular calcium source (GO:0035584)2.30473037
192toxin metabolic process (GO:0009404)2.30330470
193protein localization to endosome (GO:0036010)2.29757109
194positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.26753805
195cellular response to leptin stimulus (GO:0044320)2.25418465
196L-ascorbic acid metabolic process (GO:0019852)2.24953701
197negative regulation of glial cell differentiation (GO:0045686)2.24626478
198chemosensory behavior (GO:0007635)13.4025669
199sensory perception of chemical stimulus (GO:0007606)13.2186242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.67774431
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.47268457
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.08474609
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48582144
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.47686455
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.46268579
7VDR_21846776_ChIP-Seq_THP-1_Human3.15382608
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.93866597
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.88534230
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72374006
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70481383
12DROSHA_22980978_ChIP-Seq_HELA_Human2.69054937
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.62953325
14SPI1_23547873_ChIP-Seq_NB4_Human2.60657304
15VDR_24763502_ChIP-Seq_THP-1_Human2.54843212
16SPI1_23127762_ChIP-Seq_K562_Human2.54118065
17MAF_26560356_Chip-Seq_TH1_Human2.48291308
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.45238428
19ZNF263_19887448_ChIP-Seq_K562_Human2.44892914
20UTX_26944678_Chip-Seq_JUKART_Human2.43744405
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43401972
22RUNX1_22412390_ChIP-Seq_EML_Mouse2.34135668
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33315038
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30969834
25RUNX_20019798_ChIP-Seq_JUKART_Human2.30926986
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24680016
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15284330
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15284330
29MAF_26560356_Chip-Seq_TH2_Human2.14706217
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.10860772
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10029126
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08107117
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01789032
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01011569
35SCL_19346495_ChIP-Seq_HPC-7_Human1.97703621
36MYB_26560356_Chip-Seq_TH2_Human1.97171098
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.94725580
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90827911
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88930420
40KDM2B_26808549_Chip-Seq_K562_Human1.83426321
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83395127
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82387587
43MYB_26560356_Chip-Seq_TH1_Human1.81918831
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80408110
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80150868
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73963334
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70726632
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.69987247
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.68758862
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.67980883
51CLOCK_20551151_ChIP-Seq_293T_Human1.67857634
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66312876
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.66002205
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65893916
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65677147
56BCL6_27268052_Chip-Seq_Bcells_Human1.65059672
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63105805
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62552588
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59603889
60EZH2_22144423_ChIP-Seq_EOC_Human1.57845822
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57570137
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56742291
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54259671
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54118368
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52948133
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50730294
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.49299286
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48962103
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48283327
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48203952
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46508100
72BCOR_27268052_Chip-Seq_Bcells_Human1.46412779
73* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46326411
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44515830
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42784013
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42760372
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.42650595
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42650486
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40928835
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39498006
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39161262
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38409064
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36994581
84LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36862000
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.36721894
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36397930
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36370549
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34372935
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34219808
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33531189
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33308416
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33205831
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32932829
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.32355800
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32137055
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31867479
97P68_20966046_ChIP-Seq_HELA_Human1.31555627
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.29890300
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28145441
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27909706
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27690854
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27666562
103* ELF1_20517297_ChIP-Seq_JURKAT_Human1.27360977
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26608423
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.26597596
106JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26558282
107AHR_22903824_ChIP-Seq_MCF-7_Human1.26039995
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23978645
109LXR_22292898_ChIP-Seq_THP-1_Human1.23512403
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23209153
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22756488
112TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22658842
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21341484
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20900777
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.20747169
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.20045230
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.19108060
118SA1_27219007_Chip-Seq_ERYTHROID_Human1.18762050
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.18080698
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17945886
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17567818
122EZH2_27294783_Chip-Seq_ESCs_Mouse1.17022077
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16385965
124ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15930820
125TAF15_26573619_Chip-Seq_HEK293_Human1.14881320
126KDM2B_26808549_Chip-Seq_JURKAT_Human1.14401924
127RACK7_27058665_Chip-Seq_MCF-7_Human1.14376306
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14210104
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12472322
130CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12458742
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12190117
132ERG_20517297_ChIP-Seq_VCAP_Human1.11308393
133GATA3_24758297_ChIP-Seq_MCF-7_Human1.11284685
134NCOR1_26117541_ChIP-Seq_K562_Human1.10597813
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10109108
136* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.09438379
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09079674
138WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09015460
139EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07831469
140ATF3_27146783_Chip-Seq_COLON_Human1.07746553
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07145332
142GATA1_19941826_ChIP-Seq_K562_Human1.06577850
143PU_27001747_Chip-Seq_BMDM_Mouse1.06464912
144VDR_24787735_ChIP-Seq_THP-1_Human1.06411151
145SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06161411
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06109986
147GATA3_26560356_Chip-Seq_TH2_Human1.05704544
148SMC4_20622854_ChIP-Seq_HELA_Human1.05682043
149GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04699985
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04305422
151RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03869064
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03698144
153GATA3_27048872_Chip-Seq_THYMUS_Human1.03513613
154EGR1_19374776_ChIP-ChIP_THP-1_Human1.03066949
155CREB1_26743006_Chip-Seq_LNCaP_Human1.02867428
156ARNT_22903824_ChIP-Seq_MCF-7_Human1.01787471
157E2F1_20622854_ChIP-Seq_HELA_Human1.01769588
158STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01148856
159RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00863083
160EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99118346
161* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99017215
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.98431695
163MYC_22102868_ChIP-Seq_BL_Human0.98125368
164RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98005102
165ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97515352
166GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96451271
167KDM2B_26808549_Chip-Seq_DND41_Human0.95750367
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94862675
169CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94504022
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.94346755
171VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94324890
172BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94141046
173KLF5_25053715_ChIP-Seq_YYC3_Human0.93736450
174DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93542686
175PHF8_20622854_ChIP-Seq_HELA_Human0.93131150
176TCF7_22412390_ChIP-Seq_EML_Mouse0.92040678
177FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91391447
178AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91071830
179CDX2_20551321_ChIP-Seq_CACO-2_Human0.90902670
180SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.90797255
181NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90375903
182TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90249058
183OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89790893
184FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87160782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005394_taste/olfaction_phenotype7.09871808
2MP0005499_abnormal_olfactory_system7.09871808
3MP0008789_abnormal_olfactory_epithelium6.20337753
4MP0003724_increased_susceptibility_to5.11376036
5MP0003436_decreased_susceptibility_to4.50163570
6MP0008875_abnormal_xenobiotic_pharmacok4.35481503
7MP0003303_peritoneal_inflammation3.92690631
8MP0010030_abnormal_orbit_morphology3.52194075
9MP0001835_abnormal_antigen_presentation3.19781881
10MP0002419_abnormal_innate_immunity3.12236035
11MP0006082_CNS_inflammation2.97002063
12MP0005671_abnormal_response_to2.89583574
13MP0001790_abnormal_immune_system2.87706302
14MP0005387_immune_system_phenotype2.87706302
15MP0005025_abnormal_response_to2.85247645
16MP0001800_abnormal_humoral_immune2.82281166
17MP0003300_gastrointestinal_ulcer2.78442128
18MP0005000_abnormal_immune_tolerance2.67351160
19MP0000685_abnormal_immune_system2.65555976
20MP0002420_abnormal_adaptive_immunity2.53654645
21MP0002723_abnormal_immune_serum2.53546741
22MP0001819_abnormal_immune_cell2.51380812
23MP0009785_altered_susceptibility_to2.50043335
24MP0002452_abnormal_antigen_presenting2.37426998
25MP0002132_abnormal_respiratory_system2.24529511
26MP0002233_abnormal_nose_morphology2.20846438
27MP0003191_abnormal_cellular_cholesterol2.18422037
28MP0003763_abnormal_thymus_physiology2.17998116
29MP0001533_abnormal_skeleton_physiology2.12207189
30MP0002405_respiratory_system_inflammati2.04676647
31MP0008260_abnormal_autophagy2.03079363
32MP0001984_abnormal_olfaction12.5266037
33MP0003866_abnormal_defecation1.96464343
34MP0005464_abnormal_platelet_physiology1.95108008
35MP0002148_abnormal_hypersensitivity_rea1.94909781
36MP0004885_abnormal_endolymph1.94586601
37MP0004381_abnormal_hair_follicle1.94219852
38MP0002398_abnormal_bone_marrow1.93043489
39MP0000716_abnormal_immune_system1.87426192
40MP0010155_abnormal_intestine_physiology1.84962522
41MP0003183_abnormal_peptide_metabolism1.82860816
42MP0003172_abnormal_lysosome_physiology1.81765934
43MP0005248_abnormal_Harderian_gland1.65989970
44MP0001346_abnormal_lacrimal_gland1.62462218
45MP0001485_abnormal_pinna_reflex1.62243687
46MP0002396_abnormal_hematopoietic_system1.61953087
47MP0001845_abnormal_inflammatory_respons1.60529130
48MP0003828_pulmonary_edema1.58294010
49MP0002722_abnormal_immune_system1.56368604
50MP0000689_abnormal_spleen_morphology1.55274389
51MP0003806_abnormal_nucleotide_metabolis1.50303881
52MP0000703_abnormal_thymus_morphology1.50059675
53MP0009333_abnormal_splenocyte_physiolog1.49629433
54MP0002429_abnormal_blood_cell1.49329195
55MP0005623_abnormal_meninges_morphology1.43205804
56MP0004947_skin_inflammation1.42738868
57MP0005451_abnormal_body_composition1.40372123
58MP0005075_abnormal_melanosome_morpholog1.40221090
59MP0000490_abnormal_crypts_of1.36390943
60MP0004883_abnormal_blood_vessel1.34516200
61MP0008469_abnormal_protein_level1.34478413
62MP0001851_eye_inflammation1.34194348
63MP0010234_abnormal_vibrissa_follicle1.29637550
64MP0003011_delayed_dark_adaptation1.29452033
65MP0009764_decreased_sensitivity_to1.29177710
66MP0004510_myositis1.25913541
67MP0009278_abnormal_bone_marrow1.25772201
68MP0002653_abnormal_ependyma_morphology1.22329264
69MP0001849_ear_inflammation1.22085170
70MP0002909_abnormal_adrenal_gland1.19655774
71MP0000015_abnormal_ear_pigmentation1.17887035
72MP0005310_abnormal_salivary_gland1.16109193
73MP0003690_abnormal_glial_cell1.14535985
74MP0006292_abnormal_olfactory_placode1.13260939
75MP0002184_abnormal_innervation1.13163651
76MP0000858_altered_metastatic_potential1.09828931
77MP0000534_abnormal_ureter_morphology1.05753911
78MP0001663_abnormal_digestive_system1.05366083
79MP0000516_abnormal_urinary_system1.05067143
80MP0005367_renal/urinary_system_phenotyp1.05067143
81MP0005083_abnormal_biliary_tract1.03728172
82MP0001986_abnormal_taste_sensitivity1.02569608
83MP0000566_synostosis1.01364875
84MP0002998_abnormal_bone_remodeling1.00825418
85MP0002139_abnormal_hepatobiliary_system0.98234235
86MP0004134_abnormal_chest_morphology0.98065129
87MP0005164_abnormal_response_to0.97138596
88MP0008874_decreased_physiological_sensi0.96488060
89MP0000049_abnormal_middle_ear0.93135460
90MP0009053_abnormal_anal_canal0.92268739
91MP0005365_abnormal_bile_salt0.92077433
92MP0003787_abnormal_imprinting0.87669923
93MP0001873_stomach_inflammation0.86577459
94MP0003938_abnormal_ear_development0.86187447
95MP0005187_abnormal_penis_morphology0.83247160
96MP0002752_abnormal_somatic_nervous0.82976970
97MP0005390_skeleton_phenotype0.82674543
98MP0005166_decreased_susceptibility_to0.81777502
99MP0002249_abnormal_larynx_morphology0.81515914
100MP0003329_amyloid_beta_deposits0.81279620
101MP0003942_abnormal_urinary_system0.80745721
102MP0000631_abnormal_neuroendocrine_gland0.80688590
103MP0004130_abnormal_muscle_cell0.80455890
104MP0003705_abnormal_hypodermis_morpholog0.80310277
105MP0000613_abnormal_salivary_gland0.79605547
106MP0003937_abnormal_limbs/digits/tail_de0.77356010
107MP0003122_maternal_imprinting0.76708900
108MP0002933_joint_inflammation0.75096948
109MP0003045_fibrosis0.75078740
110MP0005397_hematopoietic_system_phenotyp0.74007050
111MP0001545_abnormal_hematopoietic_system0.74007050
112MP0001293_anophthalmia0.73818906
113MP0003075_altered_response_to0.73005339
114MP0004858_abnormal_nervous_system0.72087600
115MP0005058_abnormal_lysosome_morphology0.71308086
116MP0008004_abnormal_stomach_pH0.70114068
117MP0003566_abnormal_cell_adhesion0.69474443
118MP0003755_abnormal_palate_morphology0.69432706
119MP0002234_abnormal_pharynx_morphology0.67834371
120MP0002882_abnormal_neuron_morphology0.66366901
121MP0002092_abnormal_eye_morphology0.66299824
122MP0002928_abnormal_bile_duct0.66218969
123MP0009250_abnormal_appendicular_skeleto0.64717882
124MP0000762_abnormal_tongue_morphology0.63887620
125MP0000428_abnormal_craniofacial_morphol0.63741673
126MP0004133_heterotaxia0.63678794
127MP0002822_catalepsy0.63461301
128MP0005408_hypopigmentation0.63447004
129MP0009765_abnormal_xenobiotic_induced0.62770513
130MP0009763_increased_sensitivity_to0.62702293
131MP0002168_other_aberrant_phenotype0.62320702
132MP0003448_altered_tumor_morphology0.59700949
133MP0005381_digestive/alimentary_phenotyp0.57938655
134MP0005551_abnormal_eye_electrophysiolog0.57837449
135MP0003795_abnormal_bone_structure0.57795641
136MP0005377_hearing/vestibular/ear_phenot0.57647036
137MP0003878_abnormal_ear_physiology0.57647036
138MP0010329_abnormal_lipoprotein_level0.57268902
139MP0000778_abnormal_nervous_system0.57056124
140MP0002896_abnormal_bone_mineralization0.56649015
141MP0000343_altered_response_to0.54512507
142MP0000678_abnormal_parathyroid_gland0.52879453
143MP0005167_abnormal_blood-brain_barrier0.52771394
144MP0009780_abnormal_chondrocyte_physiolo0.52148736
145MP0000470_abnormal_stomach_morphology0.52078445
146MP0001486_abnormal_startle_reflex0.51899878
147MP0004859_abnormal_synaptic_plasticity0.50564846
148MP0002734_abnormal_mechanical_nocicepti0.50292746
149MP0000249_abnormal_blood_vessel0.50185202
150MP0003635_abnormal_synaptic_transmissio0.49656830
151MP0002063_abnormal_learning/memory/cond0.49558100
152MP0003935_abnormal_craniofacial_develop0.48721378
153MP0005388_respiratory_system_phenotype0.46874872
154MP0002133_abnormal_respiratory_system0.46874872
155MP0000371_diluted_coat_color0.46826423
156MP0003195_calcinosis0.46770722
157MP0003221_abnormal_cardiomyocyte_apopto0.46725919
158MP0000465_gastrointestinal_hemorrhage0.45799685
159MP0002152_abnormal_brain_morphology0.44753947
160MP0000579_abnormal_nail_morphology0.44332507
161MP0003633_abnormal_nervous_system0.44296287
162MP0003385_abnormal_body_wall0.43762431
163MP0006072_abnormal_retinal_apoptosis0.43352506
164MP0002098_abnormal_vibrissa_morphology0.42686665
165MP0005266_abnormal_metabolism0.42082774
166MP0003861_abnormal_nervous_system0.41075261
167MP0004043_abnormal_pH_regulation0.40796711
168MP0000537_abnormal_urethra_morphology0.40683800
169MP0002116_abnormal_craniofacial_bone0.40606272
170MP0002932_abnormal_joint_morphology0.39827320
171MP0002111_abnormal_tail_morphology0.39474916
172MP0000604_amyloidosis0.39094949
173MP0005508_abnormal_skeleton_morphology0.38565424
174MP0004811_abnormal_neuron_physiology0.38372793
175MP0008961_abnormal_basal_metabolism0.38032106
176MP0001270_distended_abdomen0.37962863
177MP0002277_abnormal_respiratory_mucosa0.36834681
178MP0005584_abnormal_enzyme/coenzyme_acti0.36190522
179MP0005195_abnormal_posterior_eye0.35747336
180MP0005391_vision/eye_phenotype0.35347975
181MP0002177_abnormal_outer_ear0.35151383
182MP0002272_abnormal_nervous_system0.34540200
183MP0004742_abnormal_vestibular_system0.34490924
184MP0002557_abnormal_social/conspecific_i0.34196176
185MP0001299_abnormal_eye_distance/0.32906865
186MP0001340_abnormal_eyelid_morphology0.32210357
187MP0001915_intracranial_hemorrhage0.31577684
188MP0006054_spinal_hemorrhage0.31103243
189MP0001963_abnormal_hearing_physiology0.30602012

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.19711194
2Myositis (HP:0100614)6.28934517
3Recurrent abscess formation (HP:0002722)6.25812349
4Recurrent bacterial skin infections (HP:0005406)6.06705817
5Orchitis (HP:0100796)5.86812473
6Abnormality of macrophages (HP:0004311)5.54036066
7Stomatitis (HP:0010280)5.39930253
8Hypochromic microcytic anemia (HP:0004840)5.33225465
9Optic neuritis (HP:0100653)5.33010496
10Retrobulbar optic neuritis (HP:0100654)5.33010496
11Elevated erythrocyte sedimentation rate (HP:0003565)5.30784525
12Decreased circulating renin level (HP:0003351)5.21149956
13Recurrent gram-negative bacterial infections (HP:0005420)5.20263599
14Ulnar bowing (HP:0003031)5.05910360
15Lip pit (HP:0100267)4.71542783
16Gastrointestinal infarctions (HP:0005244)4.64104113
17Atrioventricular block (HP:0001678)4.54051068
18Obstructive lung disease (HP:0006536)4.51653277
19Chronic obstructive pulmonary disease (HP:0006510)4.51653277
20Abnormal delayed hypersensitivity skin test (HP:0002963)4.22640439
21Hypochromic anemia (HP:0001931)4.18867667
22Bifid scrotum (HP:0000048)4.16653066
23Recurrent fungal infections (HP:0002841)4.00774672
24Encephalitis (HP:0002383)3.98905393
25Prolonged QT interval (HP:0001657)3.95568698
26Mediastinal lymphadenopathy (HP:0100721)3.95471391
27Meningitis (HP:0001287)3.93646229
28Recurrent skin infections (HP:0001581)3.88462128
29Increased IgE level (HP:0003212)3.87626555
30Limb dystonia (HP:0002451)3.85678025
31Keratoconjunctivitis sicca (HP:0001097)3.75720497
32Urticaria (HP:0001025)3.75672400
33Bronchomalacia (HP:0002780)3.74478020
34Spontaneous hematomas (HP:0007420)3.68077619
35Syncope (HP:0001279)3.61506172
36Hyperaldosteronism (HP:0000859)3.60968034
37Abnormality of dentin (HP:0010299)3.59694569
38Abnormality of sodium homeostasis (HP:0010931)3.58937945
39Gingivitis (HP:0000230)3.55776971
40Episodic fever (HP:0001954)3.53102134
41Keratoconjunctivitis (HP:0001096)3.49334000
42Chest pain (HP:0100749)3.48792005
43Palpitations (HP:0001962)3.47072104
44Humeroradial synostosis (HP:0003041)3.43510323
45Synostosis involving the elbow (HP:0003938)3.43510323
46Prolonged bleeding time (HP:0003010)3.37195879
47Peritonitis (HP:0002586)3.35765053
48Abnormal drinking behavior (HP:0030082)3.35726583
49Polydipsia (HP:0001959)3.35726583
50Chronic mucocutaneous candidiasis (HP:0002728)3.31703513
51Recurrent cutaneous fungal infections (HP:0011370)3.31703513
52Vasculitis (HP:0002633)3.28275607
53Abnormality of macular pigmentation (HP:0008002)3.25628622
54Abnormality of renin-angiotensin system (HP:0000847)3.10676189
55Cellulitis (HP:0100658)3.02749833
56Vaginal fistula (HP:0004320)2.94358491
57Bowed forearm bones (HP:0003956)2.92440761
58Bowing of the arm (HP:0006488)2.92440761
59Microcytic anemia (HP:0001935)2.91704093
60Anorexia (HP:0002039)2.90386220
61Inflammation of the large intestine (HP:0002037)2.89484181
62Biconcave vertebral bodies (HP:0004586)2.89032399
63Choanal stenosis (HP:0000452)2.88575253
64Bony spicule pigmentary retinopathy (HP:0007737)2.87787128
65Heart block (HP:0012722)2.84922101
66Abnormal EKG (HP:0003115)2.83913431
67Gastrointestinal inflammation (HP:0004386)2.83765558
68Metaphyseal cupping (HP:0003021)2.80236965
69Periauricular skin pits (HP:0100277)2.80076034
70Preauricular pit (HP:0004467)2.80076034
71Dysphonia (HP:0001618)2.79356262
72Gingival bleeding (HP:0000225)2.75694543
73Torticollis (HP:0000473)2.73035850
74Hemoptysis (HP:0002105)2.70169416
75Wormian bones (HP:0002645)2.69717460
76Leukocytosis (HP:0001974)2.68294880
77Increased IgM level (HP:0003496)2.68252401
78Adrenal overactivity (HP:0002717)2.67865264
79Pustule (HP:0200039)2.67247454
80Polyuria (HP:0000103)2.67144285
81Petechiae (HP:0000967)2.66415922
82Hypoplastic female external genitalia (HP:0012815)2.65738871
83Abnormal atrioventricular conduction (HP:0005150)2.65505186
84Labial hypoplasia (HP:0000066)2.65330315
85Hypokalemia (HP:0002900)2.64318741
86Vertebral compression fractures (HP:0002953)2.63613085
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61690944
88T lymphocytopenia (HP:0005403)2.61318062
89Panhypogammaglobulinemia (HP:0003139)2.60131811
90Primary atrial arrhythmia (HP:0001692)2.57818060
91Pulmonary embolism (HP:0002204)2.54660638
92Arterial thrombosis (HP:0004420)2.54374670
93Pulmonary infiltrates (HP:0002113)2.54090763
94Epistaxis (HP:0000421)2.51538348
95Lymphopenia (HP:0001888)2.51225518
96Abnormality of T cell number (HP:0011839)2.49147972
97Abnormal urine output (HP:0012590)2.46504055
98Sepsis (HP:0100806)2.44369898
99Supraventricular tachycardia (HP:0004755)2.44101599
100Abnormality of T cells (HP:0002843)2.43768821
101Severe visual impairment (HP:0001141)2.41347570
102Abnormality of the diencephalon (HP:0010662)2.40063223
103Amyloidosis (HP:0011034)2.39197904
104Atrial fibrillation (HP:0005110)2.38971379
105Supraventricular arrhythmia (HP:0005115)2.38108291
106Poikilocytosis (HP:0004447)2.35214909
107Abnormal ciliary motility (HP:0012262)2.30226990
108Papilledema (HP:0001085)2.30214907
109IgM deficiency (HP:0002850)2.29614540
110Abnormality of cells of the lymphoid lineage (HP:0012140)2.27755782
111Craniofacial dystonia (HP:0012179)2.27515515
112Femoral bowing (HP:0002980)2.26683260
113Tubulointerstitial fibrosis (HP:0005576)2.26107701
114Anosmia (HP:0000458)2.25635873
115Hypercalciuria (HP:0002150)2.25112133
116Abnormal respiratory motile cilium physiology (HP:0012261)2.23700526
117Hypergammaglobulinemia (HP:0010702)2.21968548
118Bilateral sensorineural hearing impairment (HP:0008619)2.21032873
119Abnormality of the heme biosynthetic pathway (HP:0010472)2.19451610
120Skin pits (HP:0100276)2.19419606
121Abnormality of the aortic arch (HP:0012303)2.19242248
122Abnormality of the peritoneum (HP:0002585)2.17415307
123Abnormality of T cell physiology (HP:0011840)2.17141117
124Subacute progressive viral hepatitis (HP:0006572)2.16482361
125Osteomyelitis (HP:0002754)2.15916564
126Abnormal platelet volume (HP:0011876)2.15372948
127Granulocytopenia (HP:0001913)2.14967417
128Short 4th metacarpal (HP:0010044)2.14585483
129Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14585483
130Abnormality of renal excretion (HP:0011036)2.14047017
131Abnormal respiratory motile cilium morphology (HP:0005938)2.13766319
132Abnormal respiratory epithelium morphology (HP:0012253)2.13766319
133Colitis (HP:0002583)2.13747181
134Atonic seizures (HP:0010819)2.13406245
135Insomnia (HP:0100785)2.13157094
136Constricted visual fields (HP:0001133)2.12558140
137Hepatosplenomegaly (HP:0001433)2.11941567
138Scrotal hypoplasia (HP:0000046)2.11431218
139Purpura (HP:0000979)2.11223784
140Abnormality of the pleura (HP:0002103)2.09701706
141Recurrent viral infections (HP:0004429)2.09331525
142Focal dystonia (HP:0004373)2.08401211
143Viral hepatitis (HP:0006562)2.07748015
144Absence seizures (HP:0002121)2.07599529
145Abnormal rod and cone electroretinograms (HP:0008323)2.05957336
146Hemivertebrae (HP:0002937)2.05026475
147Abnormality of potassium homeostasis (HP:0011042)2.04590045
148Gangrene (HP:0100758)2.04021738
149Carpal synostosis (HP:0009702)2.03862057
150Protrusio acetabuli (HP:0003179)2.03488600
151Toxemia of pregnancy (HP:0100603)2.03388993
152Persistence of primary teeth (HP:0006335)2.03355919
153Choroideremia (HP:0001139)2.02134372
154Beaking of vertebral bodies (HP:0004568)2.00355614
155Ketoacidosis (HP:0001993)2.00223856
156Arnold-Chiari malformation (HP:0002308)1.98114806
157Premature loss of primary teeth (HP:0006323)1.94131685
158Recurrent pneumonia (HP:0006532)1.93707891
159Tarsal synostosis (HP:0008368)1.93541732
160Acne (HP:0001061)1.93294129
161Loss of speech (HP:0002371)1.93186999
162Abnormality of the pericardium (HP:0001697)1.93110347
163Abnormality of the endocardium (HP:0004306)1.92093947
164Keratitis (HP:0000491)1.91981639
165Ventricular fibrillation (HP:0001663)1.91571423
166Facial hemangioma (HP:0000329)1.91193870
167Slow saccadic eye movements (HP:0000514)1.90687257
168Hypermelanotic macule (HP:0001034)1.90529525
169Acute hepatic failure (HP:0006554)1.84935624
170Right ventricular cardiomyopathy (HP:0011663)1.83583081
171Skin ulcer (HP:0200042)1.82978423
172Cerebral inclusion bodies (HP:0100314)1.82554233
173Vertigo (HP:0002321)1.81616320
174Glomerulopathy (HP:0100820)1.80122670
175Chronic otitis media (HP:0000389)1.79851520
176Morphological abnormality of the middle ear (HP:0008609)1.79468523
177Recurrent lower respiratory tract infections (HP:0002783)1.79381228
178Abnormal hemoglobin (HP:0011902)1.76986411
179Nasal polyposis (HP:0100582)1.76260338
180Arterial tortuosity (HP:0005116)1.75815776
181Chronic bronchitis (HP:0004469)1.75481150
182Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75381268
183Hypercortisolism (HP:0001578)1.74762495
184Shallow orbits (HP:0000586)1.70877377
185Abnormality of the gastric mucosa (HP:0004295)1.70575918
186Synostosis involving bones of the lower limbs (HP:0009138)1.68657949
187Synostosis involving bones of the feet (HP:0009140)1.68657949
188Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67590382
189Severe short stature (HP:0003510)1.65990933
190Abnormality of the labia (HP:0000058)1.65658836
191Polycythemia (HP:0001901)1.65297885
192Abnormality of the intervertebral disk (HP:0005108)1.65221123
193Median cleft lip (HP:0000161)1.65117388
194Scapular winging (HP:0003691)1.65023676
195Natal tooth (HP:0000695)1.64308716
196Renal tubular acidosis (HP:0001947)1.63713154
197Broad metatarsal (HP:0001783)1.62495852
198Turricephaly (HP:0000262)1.62485253
199Camptodactyly of toe (HP:0001836)1.61823930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.27178133
2RIPK44.53880123
3MAP4K13.68340770
4MAPK153.50102235
5IRAK43.12882868
6CSK3.11506396
7BLK3.02587087
8TNK23.00821227
9TYRO32.98337432
10SIK22.77544084
11MAP2K32.77128020
12NUAK12.76697825
13FES2.57949976
14TYK22.48658918
15SIK12.41304969
16RIPK12.35681708
17ZAP702.30459295
18LMTK22.28561041
19TAOK12.23769487
20CAMK2B2.21231735
21CAMK2D2.20859626
22PAK32.19816049
23BUB12.15894651
24FRK2.04467680
25ERBB32.01309803
26GRK61.97465577
27HCK1.95539626
28STK381.90674962
29MAP3K111.88256347
30BTK1.85878731
31HIPK21.70286549
32JAK31.66292449
33CDK191.62716731
34PRPF4B1.62229659
35TRIB31.57394968
36FGR1.57372002
37CAMK2G1.55622963
38MAP3K71.55606479
39MAP3K21.54659425
40SYK1.54498306
41KSR21.48218780
42SIK31.46223160
43EEF2K1.45777640
44PRKD21.34533943
45LYN1.32464363
46OXSR11.31982682
47TXK1.31813331
48ERN11.26942894
49CSNK1A1L1.24867031
50YES11.24342186
51TESK21.22849081
52MAP3K11.22560021
53TTK1.21420019
54FER1.21267764
55DDR21.18553949
56STK391.18175538
57DAPK21.17476254
58TGFBR21.16796402
59LCK1.16270023
60STK31.12649436
61MARK31.11374041
62DYRK1B1.08206060
63ALK1.07069159
64PRKCG1.06364735
65NEK10.99486619
66CSNK1G30.98078737
67CSF1R0.96657183
68MARK20.95902106
69MAP3K30.95312806
70EPHB10.95064899
71NTRK10.93449142
72IKBKE0.92127473
73PKN20.91191101
74CSNK1G20.90412400
75TAOK20.90348687
76PTK2B0.87718827
77TBK10.87121546
78MAP3K130.86025870
79LRRK20.84971026
80PDK10.83913217
81TAOK30.83206406
82CSNK1G10.78224756
83UHMK10.77988369
84JAK10.77029894
85PRKG20.76773446
86CDK60.76626036
87MINK10.76524881
88PTK60.75929055
89STK110.75350108
90PDPK10.75131431
91MAP2K10.74158743
92MAP3K100.73879420
93MAPKAPK30.73865399
94MAP3K60.73804943
95STK100.73534066
96CDC70.73355067
97TEC0.72547713
98MAP3K140.71610383
99SMG10.71276986
100SGK2230.69376436
101SGK4940.69376436
102TTN0.67714888
103MAPK120.65129813
104PRKCH0.64666137
105PAK60.64611831
106MAP2K20.64358553
107KIT0.63412657
108MST40.60976773
109NEK20.59285993
110RPS6KB20.55116403
111CAMK2A0.54968343
112KSR10.54640161
113PHKG20.54499471
114PHKG10.54499471
115ERBB20.54179272
116ROCK20.53949748
117MST1R0.53814073
118BRSK10.53086361
119MATK0.52656919
120BMPR20.52483840
121EPHA30.51307056
122DYRK30.51237512
123IRAK20.50590211
124PRKD10.50545542
125PRKCQ0.49504139
126PAK40.48861278
127PRKCZ0.48651396
128RAF10.48342140
129DMPK0.48195682
130RPS6KL10.46058164
131RPS6KC10.46058164
132TESK10.45924699
133BMX0.45766509
134CDK50.45046661
135IRAK10.44772522
136CAMKK10.44188947
137MAPKAPK20.43815027
138CAMK40.42891254
139MAPK70.42268827
140RPS6KA60.39968060
141RPS6KA20.39851016
142PLK30.39758725
143CSNK1E0.39657575
144MAP2K40.38003804
145IKBKB0.37446655
146MAP3K40.36485208
147RET0.36403922
148CDC42BPA0.36230459
149SGK30.34235921
150FGFR30.34109679
151PDGFRA0.34031176
152FYN0.31644140
153EPHB20.31550096
154MAP3K80.31369693
155MAPK90.31121825
156ITK0.30663508
157ICK0.29164485
158PRKCA0.29085842
159PINK10.28594746
160MAPK80.28448495
161MAPK100.28277892
162PRKCD0.28196305
163AURKA0.27123141
164PIM10.26862766
165JAK20.26844713
166MAP2K60.26485930
167FGFR40.26392382
168FGFR20.26177985
169CLK10.26067879
170PRKACG0.26039661
171RPS6KA10.25401881

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047407.30005761
2Caffeine metabolism_Homo sapiens_hsa002323.57978171
3Osteoclast differentiation_Homo sapiens_hsa043803.05419325
4Glutathione metabolism_Homo sapiens_hsa004803.00829774
5Thyroid hormone synthesis_Homo sapiens_hsa049182.86218385
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85610736
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.82180321
8Leishmaniasis_Homo sapiens_hsa051402.70690274
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.68747816
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68586082
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.66418822
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.58935002
13Staphylococcus aureus infection_Homo sapiens_hsa051502.50748611
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.49282450
15Primary immunodeficiency_Homo sapiens_hsa053402.31049517
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.29048704
17Graft-versus-host disease_Homo sapiens_hsa053322.23921107
18B cell receptor signaling pathway_Homo sapiens_hsa046622.21027785
19Allograft rejection_Homo sapiens_hsa053302.09895826
20Butanoate metabolism_Homo sapiens_hsa006502.06532135
21Tuberculosis_Homo sapiens_hsa051521.98545730
22Malaria_Homo sapiens_hsa051441.98101700
23Autoimmune thyroid disease_Homo sapiens_hsa053201.97262349
24Arachidonic acid metabolism_Homo sapiens_hsa005901.94066833
25T cell receptor signaling pathway_Homo sapiens_hsa046601.86076366
26Chemokine signaling pathway_Homo sapiens_hsa040621.85551671
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.84145045
28Acute myeloid leukemia_Homo sapiens_hsa052211.82879917
29Vibrio cholerae infection_Homo sapiens_hsa051101.82573946
30Histidine metabolism_Homo sapiens_hsa003401.80134053
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76508099
32Viral myocarditis_Homo sapiens_hsa054161.67956662
33Salivary secretion_Homo sapiens_hsa049701.67537847
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67425339
35Bile secretion_Homo sapiens_hsa049761.63507505
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61369769
37Measles_Homo sapiens_hsa051621.57325256
38beta-Alanine metabolism_Homo sapiens_hsa004101.56846311
39Antigen processing and presentation_Homo sapiens_hsa046121.55552896
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.55447604
41Sulfur metabolism_Homo sapiens_hsa009201.54448686
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54197490
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51041712
44Morphine addiction_Homo sapiens_hsa050321.50349319
45Hematopoietic cell lineage_Homo sapiens_hsa046401.48390867
46Phagosome_Homo sapiens_hsa041451.46828074
47Type I diabetes mellitus_Homo sapiens_hsa049401.45350294
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44189595
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.43697232
50VEGF signaling pathway_Homo sapiens_hsa043701.40796464
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39597988
52Sulfur relay system_Homo sapiens_hsa041221.37233804
53Non-small cell lung cancer_Homo sapiens_hsa052231.34513618
54African trypanosomiasis_Homo sapiens_hsa051431.32293367
55Toxoplasmosis_Homo sapiens_hsa051451.31450289
56Gastric acid secretion_Homo sapiens_hsa049711.31285563
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30014165
58Chemical carcinogenesis_Homo sapiens_hsa052041.25764871
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.23945716
60Collecting duct acid secretion_Homo sapiens_hsa049661.19559571
61Herpes simplex infection_Homo sapiens_hsa051681.19167570
62Influenza A_Homo sapiens_hsa051641.18933889
63Platelet activation_Homo sapiens_hsa046111.18178305
64Pancreatic cancer_Homo sapiens_hsa052121.18010097
65Circadian entrainment_Homo sapiens_hsa047131.17922943
66GABAergic synapse_Homo sapiens_hsa047271.17717028
67NF-kappa B signaling pathway_Homo sapiens_hsa040641.12270477
68Endocytosis_Homo sapiens_hsa041441.11560776
69Drug metabolism - other enzymes_Homo sapiens_hsa009831.08736954
70Legionellosis_Homo sapiens_hsa051341.08229706
71Shigellosis_Homo sapiens_hsa051311.07568201
72Regulation of autophagy_Homo sapiens_hsa041401.06294986
73Insulin secretion_Homo sapiens_hsa049111.06249188
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05991647
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05064005
76Chronic myeloid leukemia_Homo sapiens_hsa052201.02560100
77Nitrogen metabolism_Homo sapiens_hsa009101.00032516
78Synaptic vesicle cycle_Homo sapiens_hsa047210.99651002
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.98401040
80Salmonella infection_Homo sapiens_hsa051320.97084258
81Endometrial cancer_Homo sapiens_hsa052130.96472739
82Hepatitis C_Homo sapiens_hsa051600.96243004
83Apoptosis_Homo sapiens_hsa042100.96151703
84TNF signaling pathway_Homo sapiens_hsa046680.95400700
85Renal cell carcinoma_Homo sapiens_hsa052110.94919672
86Colorectal cancer_Homo sapiens_hsa052100.94670959
87Taste transduction_Homo sapiens_hsa047420.94662608
88Dopaminergic synapse_Homo sapiens_hsa047280.93313219
89Hepatitis B_Homo sapiens_hsa051610.91672571
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90526903
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.88893076
92Choline metabolism in cancer_Homo sapiens_hsa052310.86042054
93Starch and sucrose metabolism_Homo sapiens_hsa005000.85769590
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.85134365
95Estrogen signaling pathway_Homo sapiens_hsa049150.84919967
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84915240
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84582223
98cAMP signaling pathway_Homo sapiens_hsa040240.83596477
99Other glycan degradation_Homo sapiens_hsa005110.81238048
100Retinol metabolism_Homo sapiens_hsa008300.81038836
101Pyruvate metabolism_Homo sapiens_hsa006200.80735419
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79779101
103Fatty acid biosynthesis_Homo sapiens_hsa000610.79060759
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.77237813
105Ovarian steroidogenesis_Homo sapiens_hsa049130.77218310
106Axon guidance_Homo sapiens_hsa043600.76524064
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75963399
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75627255
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75457269
110Fatty acid degradation_Homo sapiens_hsa000710.75340035
111Prolactin signaling pathway_Homo sapiens_hsa049170.75304026
112FoxO signaling pathway_Homo sapiens_hsa040680.73972179
113ABC transporters_Homo sapiens_hsa020100.73017599
114Glutamatergic synapse_Homo sapiens_hsa047240.72841774
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72835849
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.70815325
117Pertussis_Homo sapiens_hsa051330.69429358
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67072182
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66521194
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66246511
121Cholinergic synapse_Homo sapiens_hsa047250.66111212
122mTOR signaling pathway_Homo sapiens_hsa041500.65436664
123Tryptophan metabolism_Homo sapiens_hsa003800.63435392
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.63212480
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63153141
126Viral carcinogenesis_Homo sapiens_hsa052030.63135006
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61348025
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60422638
129MAPK signaling pathway_Homo sapiens_hsa040100.60250736
130Inositol phosphate metabolism_Homo sapiens_hsa005620.59100688
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57285382
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56594338
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55682082
134Phenylalanine metabolism_Homo sapiens_hsa003600.55087014
135Propanoate metabolism_Homo sapiens_hsa006400.53846213
136GnRH signaling pathway_Homo sapiens_hsa049120.53107265
137HTLV-I infection_Homo sapiens_hsa051660.52699834
138ErbB signaling pathway_Homo sapiens_hsa040120.51986492
139Dilated cardiomyopathy_Homo sapiens_hsa054140.51519161
140Phototransduction_Homo sapiens_hsa047440.51402037
141Lysosome_Homo sapiens_hsa041420.51229790
142Melanogenesis_Homo sapiens_hsa049160.50969314
143Epstein-Barr virus infection_Homo sapiens_hsa051690.50813695
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50482871
145Renin secretion_Homo sapiens_hsa049240.50267029
146Rheumatoid arthritis_Homo sapiens_hsa053230.48760785
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47827694
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47802990
149Selenocompound metabolism_Homo sapiens_hsa004500.47742387
150Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46417318
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45908960
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45495654
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45256360
154Asthma_Homo sapiens_hsa053100.44846014
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44091069
156HIF-1 signaling pathway_Homo sapiens_hsa040660.44062574
157Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43697342
158Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42421472
159Oxytocin signaling pathway_Homo sapiens_hsa049210.41823988
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41125313
161Ras signaling pathway_Homo sapiens_hsa040140.41080147
162Gap junction_Homo sapiens_hsa045400.40587450
163Adherens junction_Homo sapiens_hsa045200.38983095
164Hippo signaling pathway_Homo sapiens_hsa043900.38743947
165Calcium signaling pathway_Homo sapiens_hsa040200.37239178
166Notch signaling pathway_Homo sapiens_hsa043300.36879788
167Pancreatic secretion_Homo sapiens_hsa049720.35940659
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35382169
169Rap1 signaling pathway_Homo sapiens_hsa040150.35259634
170Cysteine and methionine metabolism_Homo sapiens_hsa002700.34604774
171Arginine biosynthesis_Homo sapiens_hsa002200.32680897
172PPAR signaling pathway_Homo sapiens_hsa033200.30497154
173Adipocytokine signaling pathway_Homo sapiens_hsa049200.26572354
174Serotonergic synapse_Homo sapiens_hsa047260.26447608
175Arginine and proline metabolism_Homo sapiens_hsa003300.25019361
176Amphetamine addiction_Homo sapiens_hsa050310.24904569
177Amoebiasis_Homo sapiens_hsa051460.24351635
178Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23878979
179Vascular smooth muscle contraction_Homo sapiens_hsa042700.23259263
180Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22432861
181Insulin resistance_Homo sapiens_hsa049310.20264768
182Tight junction_Homo sapiens_hsa045300.19992871
183Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19344582
184Oocyte meiosis_Homo sapiens_hsa041140.17270195
185Hedgehog signaling pathway_Homo sapiens_hsa043400.17186748
186Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17165402
187Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16438495
188Alcoholism_Homo sapiens_hsa050340.14973201
189Mineral absorption_Homo sapiens_hsa049780.13339998
190Cocaine addiction_Homo sapiens_hsa050300.11879291

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