PRSS36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drinking behavior (GO:0042756)7.09106590
2response to pheromone (GO:0019236)6.87289519
3left/right pattern formation (GO:0060972)6.61859602
4neutrophil activation involved in immune response (GO:0002283)5.62890729
5protein localization to endosome (GO:0036010)5.55879326
6negative regulation of synaptic transmission, GABAergic (GO:0032229)5.26989435
7negative regulation of interleukin-12 production (GO:0032695)5.16042045
8response to peptidoglycan (GO:0032494)5.06705578
9glycosphingolipid catabolic process (GO:0046479)4.92255009
10positive regulation of translational initiation (GO:0045948)4.90888020
11amino sugar catabolic process (GO:0046348)4.75988511
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.67866373
13glycolipid catabolic process (GO:0019377)4.42287294
14negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.41768347
15macrophage activation involved in immune response (GO:0002281)4.41729990
16regulation of mast cell degranulation (GO:0043304)4.30056296
17immunoglobulin mediated immune response (GO:0016064)4.27281730
18regulation of dopamine secretion (GO:0014059)4.15360676
19dopamine transport (GO:0015872)4.12568159
20cellular response to thyroid hormone stimulus (GO:0097067)4.08839841
21positive regulation by symbiont of host defense response (GO:0052509)4.02544098
22modulation by symbiont of host defense response (GO:0052031)4.02544098
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02544098
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02544098
25positive regulation by organism of defense response of other organism involved in symbiotic interact4.02544098
26modulation by symbiont of host immune response (GO:0052553)4.02544098
27regulation of mononuclear cell migration (GO:0071675)4.01605919
28GDP-mannose metabolic process (GO:0019673)3.93535713
29regulation of mast cell activation involved in immune response (GO:0033006)3.93517976
30respiratory electron transport chain (GO:0022904)3.89439375
31ceramide catabolic process (GO:0046514)3.88904047
32electron transport chain (GO:0022900)3.87486485
33serotonin receptor signaling pathway (GO:0007210)3.85140017
34positive regulation of mast cell activation involved in immune response (GO:0033008)3.84776824
35positive regulation of mast cell degranulation (GO:0043306)3.84776824
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71511452
37lipopolysaccharide-mediated signaling pathway (GO:0031663)3.68413717
38positive regulation of gamma-delta T cell activation (GO:0046645)3.67687016
39regulation of leukocyte degranulation (GO:0043300)3.64833241
40N-acetylneuraminate metabolic process (GO:0006054)3.64545068
41oxidative phosphorylation (GO:0006119)3.63015862
42positive regulation of antigen processing and presentation (GO:0002579)3.62609061
43positive regulation of mast cell activation (GO:0033005)3.59443368
44ATP synthesis coupled proton transport (GO:0015986)3.56408549
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56408549
46T-helper 1 type immune response (GO:0042088)3.56353515
47positive regulation of leukocyte degranulation (GO:0043302)3.55488165
48pentose metabolic process (GO:0019321)3.55344993
49granulocyte activation (GO:0036230)3.52762442
50regulation of myeloid leukocyte mediated immunity (GO:0002886)3.51033749
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.49433640
52protein targeting to peroxisome (GO:0006625)3.47298502
53establishment of protein localization to peroxisome (GO:0072663)3.47298502
54protein localization to peroxisome (GO:0072662)3.47298502
55peroxisomal transport (GO:0043574)3.45808705
56positive regulation of protein sumoylation (GO:0033235)3.44184209
57pinocytosis (GO:0006907)3.42805998
58response to thyroid hormone (GO:0097066)3.41974197
59negative regulation of erythrocyte differentiation (GO:0045647)3.40353741
60membrane lipid catabolic process (GO:0046466)3.38631934
61myeloid dendritic cell differentiation (GO:0043011)3.38463073
62aerobic respiration (GO:0009060)3.37829066
63detection of molecule of bacterial origin (GO:0032490)3.37821348
64barbed-end actin filament capping (GO:0051016)3.37705754
65sphingolipid catabolic process (GO:0030149)3.35769673
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.35477675
67NADH dehydrogenase complex assembly (GO:0010257)3.35477675
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35477675
69protein polyglutamylation (GO:0018095)3.33629679
70regulation of cholesterol storage (GO:0010885)3.29385787
71regulation of antigen processing and presentation (GO:0002577)3.28802625
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.27591464
73regulation of mast cell activation (GO:0033003)3.27130521
74positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.26739225
75GTP biosynthetic process (GO:0006183)3.25002892
76negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.24579983
77virion attachment to host cell (GO:0019062)3.24122963
78adhesion of symbiont to host cell (GO:0044650)3.24122963
79ATP hydrolysis coupled proton transport (GO:0015991)3.23998405
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.23998405
81myeloid cell activation involved in immune response (GO:0002275)3.23473147
82regulation of interferon-beta biosynthetic process (GO:0045357)3.21928785
837-methylguanosine mRNA capping (GO:0006370)3.21475526
84glucosamine-containing compound catabolic process (GO:1901072)3.21026885
85mannose metabolic process (GO:0006013)3.18703437
86macrophage activation (GO:0042116)3.16763755
87G-protein coupled receptor internalization (GO:0002031)3.16611337
88myeloid dendritic cell activation (GO:0001773)3.16414961
89B cell mediated immunity (GO:0019724)3.16371054
90NIK/NF-kappaB signaling (GO:0038061)3.15931388
91positive regulation of chemokine biosynthetic process (GO:0045080)3.15844460
92negative regulation of nitric oxide biosynthetic process (GO:0045019)3.14470936
93guanosine-containing compound biosynthetic process (GO:1901070)3.14162316
94pancreas development (GO:0031016)3.13272984
95negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12278600
96negative regulation of cell killing (GO:0031342)3.12278600
97intracellular protein transmembrane transport (GO:0065002)3.08800797
98negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.08779380
99neutrophil activation (GO:0042119)3.07892397
100regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06373138
101cellular response to epinephrine stimulus (GO:0071872)3.06215753
102RNA capping (GO:0036260)3.04293126
1037-methylguanosine RNA capping (GO:0009452)3.04293126
104L-phenylalanine metabolic process (GO:0006558)3.02148704
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.02148704
106negative regulation of cytokine production involved in immune response (GO:0002719)3.01539319
107response to muramyl dipeptide (GO:0032495)3.00875419
108UTP biosynthetic process (GO:0006228)2.99953128
109regulation of podosome assembly (GO:0071801)2.99594305
110macrophage differentiation (GO:0030225)2.97918777
111adhesion of symbiont to host (GO:0044406)2.97840778
112adenosine receptor signaling pathway (GO:0001973)2.97071834
113monocyte chemotaxis (GO:0002548)2.96576458
114otic vesicle formation (GO:0030916)2.95829766
115protein complex biogenesis (GO:0070271)2.94622100
116positive regulation of monocyte chemotaxis (GO:0090026)2.93169754
117detection of external biotic stimulus (GO:0098581)2.93013961
118interferon-gamma-mediated signaling pathway (GO:0060333)2.92769431
119regulation of macrophage chemotaxis (GO:0010758)2.92646298
120regulation of superoxide anion generation (GO:0032928)2.92589134
121regulation of oxidative stress-induced neuron death (GO:1903203)2.92248162
122detection of other organism (GO:0098543)2.91245905
123catecholamine transport (GO:0051937)2.90986669
124response to protozoan (GO:0001562)2.90278434
125protein transmembrane transport (GO:0071806)2.90031858
126regulation of chemokine biosynthetic process (GO:0045073)2.89349120
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.87434288
128positive regulation of heat generation (GO:0031652)2.86512975
129defense response to protozoan (GO:0042832)2.86501803
130dendritic cell differentiation (GO:0097028)2.85679432
131negative regulation of myeloid cell apoptotic process (GO:0033033)2.85509872
132axoneme assembly (GO:0035082)2.85462230
133negative regulation of transcription by competitive promoter binding (GO:0010944)2.84341722
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83855412
135norepinephrine metabolic process (GO:0042415)2.83491263
136regulation of regulated secretory pathway (GO:1903305)2.82247468
137negative regulation of granulocyte differentiation (GO:0030853)2.81790420
138positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81185229
139protein-cofactor linkage (GO:0018065)2.81151828
140germinal center formation (GO:0002467)2.80801017
141regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80156825
142regulation of mitochondrial translation (GO:0070129)2.78061727
143positive regulation of cholesterol efflux (GO:0010875)2.77752473
144phagosome maturation (GO:0090382)2.77719387
145regulation of protein sumoylation (GO:0033233)2.76968735
146regulation of vitamin D biosynthetic process (GO:0060556)2.76954889
147purine nucleobase biosynthetic process (GO:0009113)2.76153882
148respiratory burst (GO:0045730)2.74355837
149low-density lipoprotein particle clearance (GO:0034383)2.74283682
150eosinophil chemotaxis (GO:0048245)2.73255032
151histamine secretion (GO:0001821)2.72312820
152erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72175505
153L-phenylalanine catabolic process (GO:0006559)2.72175505
154intracellular protein transmembrane import (GO:0044743)2.71162483
155regulation of cytokine secretion involved in immune response (GO:0002739)2.70464793
156UTP metabolic process (GO:0046051)2.70237986
157microglial cell activation (GO:0001774)2.68444526
158peroxisome organization (GO:0007031)2.67940540
159lytic vacuole organization (GO:0080171)2.67678124
160lysosome organization (GO:0007040)2.67678124
161detection of bacterium (GO:0016045)2.67656132
162regulation of monocyte chemotaxis (GO:0090025)2.66685594
163regulation of interferon-alpha production (GO:0032647)2.66576592
164centrosome localization (GO:0051642)2.64848541
165mitochondrial respiratory chain complex assembly (GO:0033108)2.64225949
166regulation of Golgi to plasma membrane protein transport (GO:0042996)2.63997923
167transcription-coupled nucleotide-excision repair (GO:0006283)2.58690071
168regulation of cholesterol metabolic process (GO:0090181)2.58266674
169transferrin transport (GO:0033572)2.58045608
170regulation of oxidative phosphorylation (GO:0002082)2.54824470
171hydrogen ion transmembrane transport (GO:1902600)2.53709441
172NADH metabolic process (GO:0006734)2.53546208
173pyrimidine nucleoside catabolic process (GO:0046135)2.51707852
174folic acid metabolic process (GO:0046655)2.50880551
175trivalent inorganic cation transport (GO:0072512)2.49706079
176ferric iron transport (GO:0015682)2.49706079
177auditory receptor cell differentiation (GO:0042491)2.49162744
178cochlea development (GO:0090102)2.49124008
179purine nucleoside triphosphate biosynthetic process (GO:0009145)2.47841749
180cellular respiration (GO:0045333)2.46245178
181nucleotide-sugar biosynthetic process (GO:0009226)2.46026537
182purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45789427
183CTP metabolic process (GO:0046036)2.44238760
184CTP biosynthetic process (GO:0006241)2.44238760
185positive regulation of viral transcription (GO:0050434)2.43869039
186L-ascorbic acid metabolic process (GO:0019852)2.42351621
187sulfur amino acid catabolic process (GO:0000098)2.42045267
188response to nitrosative stress (GO:0051409)2.40442545
189platelet dense granule organization (GO:0060155)2.39044321
190branched-chain amino acid catabolic process (GO:0009083)2.38146906
191somatic hypermutation of immunoglobulin genes (GO:0016446)2.37459987
192somatic diversification of immune receptors via somatic mutation (GO:0002566)2.37459987
193oligosaccharide catabolic process (GO:0009313)2.35672168
194regulation of cAMP-dependent protein kinase activity (GO:2000479)2.35303817
195cellular response to catecholamine stimulus (GO:0071870)2.33111122
196cellular response to monoamine stimulus (GO:0071868)2.33111122
197establishment of protein localization to mitochondrial membrane (GO:0090151)2.32537978
198negative regulation of cardiac muscle hypertrophy (GO:0010614)2.32301841
199response to epinephrine (GO:0071871)2.32204961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.08857029
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.26047186
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.58336943
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.49584438
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.27073678
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.01559550
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.51027386
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.30204502
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24564573
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14417359
11VDR_21846776_ChIP-Seq_THP-1_Human3.03321909
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85087841
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81762563
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80414760
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75317395
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70852009
17VDR_24763502_ChIP-Seq_THP-1_Human2.51799788
18EZH2_22144423_ChIP-Seq_EOC_Human2.39336255
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.38818081
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38417111
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34476581
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.34237475
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29336196
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26026817
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25546176
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.25282610
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24820584
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24608062
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.21204035
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19642799
31* SPI1_23547873_ChIP-Seq_NB4_Human2.19171202
32SPI1_23127762_ChIP-Seq_K562_Human2.18551891
33LXR_22292898_ChIP-Seq_THP-1_Human2.17971165
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17726940
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.14453210
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12695753
37RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11891682
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09005327
39BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08188969
40GABP_17652178_ChIP-ChIP_JURKAT_Human2.02461293
41SCL_19346495_ChIP-Seq_HPC-7_Human2.01284501
42STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00567846
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98018550
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87577819
45* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85104688
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.83402411
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80595097
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80456377
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79711060
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.79192287
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78610706
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77803381
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77696821
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77239103
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76782523
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76535762
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75799392
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73230039
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73202641
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70330307
61VDR_24787735_ChIP-Seq_THP-1_Human1.69558588
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.68325115
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66827298
64MAF_26560356_Chip-Seq_TH1_Human1.64498630
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61704101
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61395117
67MYC_22102868_ChIP-Seq_BL_Human1.60380411
68AR_21909140_ChIP-Seq_LNCAP_Human1.59404782
69* SRF_21415370_ChIP-Seq_HL-1_Mouse1.59323443
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59102111
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58439242
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.57939645
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54795395
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53408694
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.52910703
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52513585
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52431198
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51560376
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51470543
80DCP1A_22483619_ChIP-Seq_HELA_Human1.50830778
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49355405
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47280280
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47045937
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45503055
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45217272
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44860513
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42454738
88MAF_26560356_Chip-Seq_TH2_Human1.39606257
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39451498
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39103523
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39103523
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39103523
93UTX_26944678_Chip-Seq_JUKART_Human1.38999458
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.38983077
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38527992
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38307979
97TCF7_22412390_ChIP-Seq_EML_Mouse1.38278152
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37700258
99ZNF263_19887448_ChIP-Seq_K562_Human1.36178414
100BCL6_27268052_Chip-Seq_Bcells_Human1.36170278
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36167857
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.36024856
103KDM2B_26808549_Chip-Seq_DND41_Human1.35398464
104RXR_22158963_ChIP-Seq_LIVER_Mouse1.34610642
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34469881
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34055421
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34011653
108RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33696723
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33618089
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.33468811
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32831975
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32236791
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31956093
114BCOR_27268052_Chip-Seq_Bcells_Human1.31878588
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29808773
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29235550
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28567130
118TFEB_21752829_ChIP-Seq_HELA_Human1.28418163
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27678893
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26744238
121PU_27001747_Chip-Seq_BMDM_Mouse1.26577663
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.25633804
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23686630
124* RACK7_27058665_Chip-Seq_MCF-7_Human1.22083527
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21878530
126PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21647924
127SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20760818
128HTT_18923047_ChIP-ChIP_STHdh_Human1.19723862
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18947749
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18782834
131MYB_26560356_Chip-Seq_TH2_Human1.17824851
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17635382
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16803471
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15855396
135ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14175358
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13634010
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12268649
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12129331
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11935909
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11913674
141TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09091337
142SA1_27219007_Chip-Seq_ERYTHROID_Human1.09038214
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08054513
144ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07994305
145CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06830822
146TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06105091
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05752887
148* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05472567
149STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05321291
150XRN2_22483619_ChIP-Seq_HELA_Human1.05055115
151PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05008933
152MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04265096
153P68_20966046_ChIP-Seq_HELA_Human1.02663811
154VDR_22108803_ChIP-Seq_LS180_Human1.02646100
155CTCF_26484167_Chip-Seq_Bcells_Mouse1.02318216
156KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01812606
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01231133
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00872927
159TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00661215
160TTF2_22483619_ChIP-Seq_HELA_Human1.00633093
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99418246
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99073094
163GATA1_19941826_ChIP-Seq_K562_Human0.98750900
164MYB_26560356_Chip-Seq_TH1_Human0.98003369
165STAT1_20625510_ChIP-Seq_HELA_Human0.97709168
166FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97552326
167TET1_21451524_ChIP-Seq_MESCs_Mouse0.96990330
168RUNX_20019798_ChIP-Seq_JUKART_Human0.95794969
169VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95516192
170POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95420540
171HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95244979
172SA1_27219007_Chip-Seq_Bcells_Human0.94593637
173SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94421278
174GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94352765
175FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93967802
176EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93141131
177SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92796654
178BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90847840
179CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90845995
180SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90474111
181ELK1_22589737_ChIP-Seq_MCF10A_Human0.89853148
182YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89714082
183GABP_19822575_ChIP-Seq_HepG2_Human0.88500077
184ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88302986
185TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88004053
186CTCF_27219007_Chip-Seq_Bcells_Human0.87179394
187TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85557973
188IRF1_19129219_ChIP-ChIP_H3396_Human0.84405223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.28989488
2MP0004133_heterotaxia4.66778591
3MP0003878_abnormal_ear_physiology4.18801519
4MP0005377_hearing/vestibular/ear_phenot4.18801519
5MP0003303_peritoneal_inflammation3.93714157
6MP0006082_CNS_inflammation3.67227548
7MP0003806_abnormal_nucleotide_metabolis3.64912027
8MP0009840_abnormal_foam_cell3.35765321
9MP0003436_decreased_susceptibility_to3.28944866
10MP0002148_abnormal_hypersensitivity_rea3.14865086
11MP0002139_abnormal_hepatobiliary_system3.01221735
12MP0003172_abnormal_lysosome_physiology2.94598280
13MP0002419_abnormal_innate_immunity2.83537735
14MP0003191_abnormal_cellular_cholesterol2.75062062
15MP0003724_increased_susceptibility_to2.70139924
16MP0003283_abnormal_digestive_organ2.62172077
17MP0001835_abnormal_antigen_presentation2.59652847
18MP0005671_abnormal_response_to2.58696764
19MP0009785_altered_susceptibility_to2.58475806
20MP0008789_abnormal_olfactory_epithelium2.50814767
21MP0002132_abnormal_respiratory_system2.50018422
22MP0005025_abnormal_response_to2.45188733
23MP0005000_abnormal_immune_tolerance2.37599801
24MP0001790_abnormal_immune_system2.36047004
25MP0005387_immune_system_phenotype2.36047004
26MP0008875_abnormal_xenobiotic_pharmacok2.29142364
27MP0004510_myositis2.27487941
28MP0006036_abnormal_mitochondrial_physio2.26814459
29MP0000343_altered_response_to2.26538935
30MP0003075_altered_response_to2.21319159
31MP0003879_abnormal_hair_cell2.19398856
32MP0000604_amyloidosis2.14494450
33MP0002452_abnormal_antigen_presenting2.13307709
34MP0003300_gastrointestinal_ulcer2.10049143
35MP0009278_abnormal_bone_marrow2.07498513
36MP0003693_abnormal_embryo_hatching2.06804715
37MP0002723_abnormal_immune_serum2.06637579
38MP0001533_abnormal_skeleton_physiology2.04769334
39MP0005365_abnormal_bile_salt2.04765941
40MP0000685_abnormal_immune_system1.99657076
41MP0005451_abnormal_body_composition1.99018910
42MP0009764_decreased_sensitivity_to1.98279498
43MP0005085_abnormal_gallbladder_physiolo1.97968979
44MP0006292_abnormal_olfactory_placode1.95770562
45MP0005394_taste/olfaction_phenotype1.90743879
46MP0005499_abnormal_olfactory_system1.90743879
47MP0001545_abnormal_hematopoietic_system1.90142364
48MP0005397_hematopoietic_system_phenotyp1.90142364
49MP0001800_abnormal_humoral_immune1.89082091
50MP0002735_abnormal_chemical_nociception1.86445277
51MP0002837_dystrophic_cardiac_calcinosis1.80846598
52MP0001819_abnormal_immune_cell1.78575299
53MP0002420_abnormal_adaptive_immunity1.77717029
54MP0005670_abnormal_white_adipose1.75670503
55MP0001486_abnormal_startle_reflex1.74929784
56MP0001984_abnormal_olfaction1.73927607
57MP0000678_abnormal_parathyroid_gland1.73293146
58MP0001853_heart_inflammation1.71291370
59MP0002998_abnormal_bone_remodeling1.70516247
60MP0003186_abnormal_redox_activity1.69971542
61MP0001485_abnormal_pinna_reflex1.69334558
62MP0001845_abnormal_inflammatory_respons1.68534509
63MP0003195_calcinosis1.67758783
64MP0008469_abnormal_protein_level1.64573428
65MP0005310_abnormal_salivary_gland1.64110514
66MP0002405_respiratory_system_inflammati1.63754085
67MP0009379_abnormal_foot_pigmentation1.62032274
68MP0002254_reproductive_system_inflammat1.59651175
69MP0000858_altered_metastatic_potential1.57030061
70MP0005464_abnormal_platelet_physiology1.54954039
71MP0003718_maternal_effect1.54143676
72MP0000751_myopathy1.53998857
73MP0009333_abnormal_splenocyte_physiolog1.51272126
74MP0008004_abnormal_stomach_pH1.49879767
75MP0006072_abnormal_retinal_apoptosis1.49362138
76MP0003690_abnormal_glial_cell1.49103826
77MP0004947_skin_inflammation1.48631506
78MP0010155_abnormal_intestine_physiology1.47460001
79MP0008260_abnormal_autophagy1.43128782
80MP0005167_abnormal_blood-brain_barrier1.42136071
81MP0004043_abnormal_pH_regulation1.42015407
82MP0005360_urolithiasis1.39512871
83MP0003448_altered_tumor_morphology1.36811331
84MP0000026_abnormal_inner_ear1.36095752
85MP0006276_abnormal_autonomic_nervous1.35949356
86MP0001764_abnormal_homeostasis1.35484842
87MP0003011_delayed_dark_adaptation1.34901527
88MP0005220_abnormal_exocrine_pancreas1.33286921
89MP0001963_abnormal_hearing_physiology1.30736007
90MP0000534_abnormal_ureter_morphology1.30640089
91MP0001905_abnormal_dopamine_level1.30367338
92MP0003119_abnormal_digestive_system1.30063819
93MP0003828_pulmonary_edema1.28889674
94MP0002272_abnormal_nervous_system1.28556673
95MP0003453_abnormal_keratinocyte_physiol1.28168517
96MP0000716_abnormal_immune_system1.23589446
97MP0001529_abnormal_vocalization1.22910725
98MP0005166_decreased_susceptibility_to1.21537817
99MP0006054_spinal_hemorrhage1.20687302
100MP0003183_abnormal_peptide_metabolism1.17253633
101MP0002736_abnormal_nociception_after1.15698695
102MP0003123_paternal_imprinting1.14894733
103MP0002277_abnormal_respiratory_mucosa1.14299820
104MP0003656_abnormal_erythrocyte_physiolo1.12779954
105MP0008872_abnormal_physiological_respon1.11558994
106MP0003938_abnormal_ear_development1.10682477
107MP0002876_abnormal_thyroid_physiology1.10285031
108MP0006035_abnormal_mitochondrial_morpho1.06422456
109MP0003122_maternal_imprinting1.04500148
110MP0010329_abnormal_lipoprotein_level1.03420966
111MP0008932_abnormal_embryonic_tissue1.02102495
112MP0000689_abnormal_spleen_morphology1.01837723
113MP0002398_abnormal_bone_marrow1.00966973
114MP0004134_abnormal_chest_morphology0.98635799
115MP0002429_abnormal_blood_cell0.97411378
116MP0002184_abnormal_innervation0.96680085
117MP0001440_abnormal_grooming_behavior0.96145614
118MP0005636_abnormal_mineral_homeostasis0.95406122
119MP0003121_genomic_imprinting0.94070353
120MP0003942_abnormal_urinary_system0.93756468
121MP0010307_abnormal_tumor_latency0.93729764
122MP0000013_abnormal_adipose_tissue0.93154762
123MP0005330_cardiomyopathy0.92713719
124MP0005645_abnormal_hypothalamus_physiol0.92452756
125MP0004885_abnormal_endolymph0.91452610
126MP0005248_abnormal_Harderian_gland0.91007217
127MP0003787_abnormal_imprinting0.90826045
128MP0009745_abnormal_behavioral_response0.90631642
129MP0000920_abnormal_myelination0.90510845
130MP0005535_abnormal_body_temperature0.90453974
131MP0003329_amyloid_beta_deposits0.90433838
132MP0008058_abnormal_DNA_repair0.90281399
133MP0005165_increased_susceptibility_to0.90204588
134MP0002111_abnormal_tail_morphology0.89818452
135MP0001666_abnormal_nutrient_absorption0.88981728
136MP0000465_gastrointestinal_hemorrhage0.88491563
137MP0002722_abnormal_immune_system0.88255131
138MP0001851_eye_inflammation0.88198358
139MP0005390_skeleton_phenotype0.87561081
140MP0002557_abnormal_social/conspecific_i0.85853691
141MP0003279_aneurysm0.85725136
142MP0009763_increased_sensitivity_to0.84615346
143MP0005266_abnormal_metabolism0.84348997
144MP0000358_abnormal_cell_content/0.84025403
145MP0000537_abnormal_urethra_morphology0.83969570
146MP0001919_abnormal_reproductive_system0.82201061
147MP0001542_abnormal_bone_strength0.80693947
148MP0001663_abnormal_digestive_system0.79503924
149MP0000778_abnormal_nervous_system0.79312565
150MP0002877_abnormal_melanocyte_morpholog0.78052208
151MP0008877_abnormal_DNA_methylation0.77240548
152MP0008057_abnormal_DNA_replication0.76280091
153MP0005409_darkened_coat_color0.75850394
154MP0005319_abnormal_enzyme/_coenzyme0.75701850
155MP0003795_abnormal_bone_structure0.75260964
156MP0009250_abnormal_appendicular_skeleto0.75036983
157MP0005389_reproductive_system_phenotype0.74549469
158MP0005332_abnormal_amino_acid0.74245309
159MP0002752_abnormal_somatic_nervous0.72924181
160MP0005164_abnormal_response_to0.72588369
161MP0002063_abnormal_learning/memory/cond0.71358151
162MP0002118_abnormal_lipid_homeostasis0.71224410
163MP0001944_abnormal_pancreas_morphology0.70544725
164MP0000490_abnormal_crypts_of0.70271057
165MP0004957_abnormal_blastocyst_morpholog0.69881939
166MP0001873_stomach_inflammation0.68980103
167MP0002734_abnormal_mechanical_nocicepti0.68897574
168MP0005584_abnormal_enzyme/coenzyme_acti0.68695366
169MP0005647_abnormal_sex_gland0.68145795
170MP0002269_muscular_atrophy0.67126213
171MP0001177_atelectasis0.66450381
172MP0000609_abnormal_liver_physiology0.66362152
173MP0005408_hypopigmentation0.65824203
174MP0001968_abnormal_touch/_nociception0.65453764
175MP0000049_abnormal_middle_ear0.65177531
176MP0004883_abnormal_blood_vessel0.65048395
177MP0009765_abnormal_xenobiotic_induced0.64876541
178MP0001970_abnormal_pain_threshold0.64458875
179MP0003634_abnormal_glial_cell0.64263693
180MP0004019_abnormal_vitamin_homeostasis0.63630762
181MP0001849_ear_inflammation0.63358516
182MP0002653_abnormal_ependyma_morphology0.63296094
183MP0009053_abnormal_anal_canal0.63180701
184MP0000249_abnormal_blood_vessel0.62968141
185MP0002928_abnormal_bile_duct0.62582705
186MP0002229_neurodegeneration0.61847972
187MP0002933_joint_inflammation0.60793237
188MP0004185_abnormal_adipocyte_glucose0.56975510
189MP0002138_abnormal_hepatobiliary_system0.56159983
190MP0005076_abnormal_cell_differentiation0.52342959
191MP0002090_abnormal_vision0.52319388
192MP0002332_abnormal_exercise_endurance0.50815524
193MP0008874_decreased_physiological_sensi0.49513667

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)7.99628108
2Abnormality of glycosphingolipid metabolism (HP:0004343)7.99628108
3Abnormality of glycolipid metabolism (HP:0010969)7.99628108
4Increased cerebral lipofuscin (HP:0011813)5.85980513
5Vacuolated lymphocytes (HP:0001922)5.67938032
6Renal cortical cysts (HP:0000803)5.62512341
7Tubulointerstitial nephritis (HP:0001970)5.38012983
8Systemic lupus erythematosus (HP:0002725)5.26038221
9Increased neuronal autofluorescent lipopigment (HP:0002074)5.09342076
10Dysostosis multiplex (HP:0000943)5.08017407
11Disinhibition (HP:0000734)5.02734593
12Stenosis of the external auditory canal (HP:0000402)4.98970288
13Abnormality of macrophages (HP:0004311)4.75095059
14Recurrent bacterial skin infections (HP:0005406)4.54485269
15Recurrent abscess formation (HP:0002722)4.51138717
16Loss of speech (HP:0002371)4.40021466
17Abnormal hemoglobin (HP:0011902)4.22583601
18Mutism (HP:0002300)4.15955957
19Acute necrotizing encephalopathy (HP:0006965)4.04880944
20Aplasia involving bones of the extremities (HP:0009825)3.94335547
21Aplasia involving bones of the upper limbs (HP:0009823)3.94335547
22Aplasia of the phalanges of the hand (HP:0009802)3.94335547
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.91649388
24Abnormality of polysaccharide metabolism (HP:0011012)3.91649388
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.91649388
26Brushfield spots (HP:0001088)3.90010254
27Eczematoid dermatitis (HP:0000976)3.88589539
28Abnormal mitochondria in muscle tissue (HP:0008316)3.75420586
29Axonal loss (HP:0003447)3.73474955
30Mucopolysacchariduria (HP:0008155)3.64216567
31Urinary glycosaminoglycan excretion (HP:0003541)3.64216567
32Lip pit (HP:0100267)3.62926013
33Fibular aplasia (HP:0002990)3.61172223
34Hyperkalemia (HP:0002153)3.61063734
35Acute encephalopathy (HP:0006846)3.60808532
36Hepatocellular necrosis (HP:0001404)3.57612981
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.47599589
38Enlarged kidneys (HP:0000105)3.46983973
39Recurrent gram-negative bacterial infections (HP:0005420)3.43293802
40Glomerulonephritis (HP:0000099)3.43219962
41Hepatic necrosis (HP:0002605)3.40496764
42Nuclear cataract (HP:0100018)3.35441293
43Spontaneous hematomas (HP:0007420)3.30842308
44Mitochondrial inheritance (HP:0001427)3.29563768
45Delayed CNS myelination (HP:0002188)3.25411147
46Mediastinal lymphadenopathy (HP:0100721)3.21164624
47Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.20871427
48Short 1st metacarpal (HP:0010034)3.20871427
49Abnormality of the vasculature of the conjunctiva (HP:0008054)3.17012692
50Progressive macrocephaly (HP:0004481)3.12623857
51Orchitis (HP:0100796)3.09931631
52Myositis (HP:0100614)3.07740282
53Agnosia (HP:0010524)3.06671101
54Upper motor neuron abnormality (HP:0002127)3.06171050
55Purpura (HP:0000979)2.99750939
56Autoimmune thrombocytopenia (HP:0001973)2.98043415
57Increased CSF lactate (HP:0002490)2.93664187
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87502485
59Respiratory failure (HP:0002878)2.87137625
60Chronic obstructive pulmonary disease (HP:0006510)2.83635542
61Obstructive lung disease (HP:0006536)2.83635542
62Cerebral edema (HP:0002181)2.83557638
63Neurofibrillary tangles (HP:0002185)2.82845557
64Fibular hypoplasia (HP:0003038)2.81701453
65Apathy (HP:0000741)2.80083165
66Abnormality of the renal cortex (HP:0011035)2.76903696
67Diminished motivation (HP:0000745)2.76779840
68Amyloidosis (HP:0011034)2.75189455
69Retrobulbar optic neuritis (HP:0100654)2.74279591
70Optic neuritis (HP:0100653)2.74279591
71Inappropriate behavior (HP:0000719)2.72664611
72Complement deficiency (HP:0004431)2.71551591
73Increased serum ferritin (HP:0003281)2.70223228
74Abnormality of the 1st metacarpal (HP:0010009)2.69833424
75Glossoptosis (HP:0000162)2.69402038
76Recurrent skin infections (HP:0001581)2.66422642
77Stomatitis (HP:0010280)2.65605127
78Thoracic kyphosis (HP:0002942)2.62316210
79Facial hemangioma (HP:0000329)2.61574581
80Osteomalacia (HP:0002749)2.60503939
81Aplasia/Hypoplasia of the fibula (HP:0006492)2.56060768
82Progressive neurologic deterioration (HP:0002344)2.54990013
83Neuronal loss in central nervous system (HP:0002529)2.54558471
84Petechiae (HP:0000967)2.51969241
85Pathologic fracture (HP:0002756)2.50668122
86Hepatosplenomegaly (HP:0001433)2.47019872
87Abnormality of the diencephalon (HP:0010662)2.45246002
88Hematochezia (HP:0002573)2.45134779
89Personality changes (HP:0000751)2.45099474
90Abnormality of the renal medulla (HP:0100957)2.42574920
91Abnormality of glycolysis (HP:0004366)2.40823607
92Increased serum pyruvate (HP:0003542)2.40823607
93Pancreatic cysts (HP:0001737)2.40509411
94Molar tooth sign on MRI (HP:0002419)2.39994920
95Abnormality of midbrain morphology (HP:0002418)2.39994920
96Myocardial infarction (HP:0001658)2.39859875
97Broad alveolar ridges (HP:0000187)2.30433941
98Gingivitis (HP:0000230)2.29657659
99Bell-shaped thorax (HP:0001591)2.29391030
100Hypoplasia of the uterus (HP:0000013)2.27046659
101Thickened nuchal skin fold (HP:0000474)2.26474735
102Vertebral compression fractures (HP:0002953)2.24079725
103Abnormality of complement system (HP:0005339)2.23083825
104Hyperglycinuria (HP:0003108)2.23069255
105Recurrent fungal infections (HP:0002841)2.22388760
106Dementia (HP:0000726)2.22159720
107Popliteal pterygium (HP:0009756)2.22012372
108Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20520050
109Mixed hearing impairment (HP:0000410)2.20069825
110Posterior embryotoxon (HP:0000627)2.19014814
111Gout (HP:0001997)2.17280526
112Posterior subcapsular cataract (HP:0007787)2.16286308
113Nasolacrimal duct obstruction (HP:0000579)2.14661634
114Shawl scrotum (HP:0000049)2.14623235
115Meningitis (HP:0001287)2.13577380
116Polyneuropathy (HP:0001271)2.13449269
117Retinal atrophy (HP:0001105)2.11876588
118Abnormality of the labia minora (HP:0012880)2.09598136
119Hypochromic microcytic anemia (HP:0004840)2.09370918
120Lethargy (HP:0001254)2.08355226
121Abnormality of iron homeostasis (HP:0011031)2.07841885
122Pulmonary infiltrates (HP:0002113)2.05584463
123Abnormality of the line of Schwalbe (HP:0008048)2.05305362
124J-shaped sella turcica (HP:0002680)2.03945513
125Basal ganglia calcification (HP:0002135)2.02904536
126Urticaria (HP:0001025)2.02902412
127Metaphyseal irregularity (HP:0003025)2.02298659
128X-linked dominant inheritance (HP:0001423)2.01662005
129Aplasia/hypoplasia of the uterus (HP:0008684)2.01177196
130Conjunctival telangiectasia (HP:0000524)2.00945822
131Prolonged neonatal jaundice (HP:0006579)1.98405713
132Epiphyseal stippling (HP:0010655)1.97190423
133Pustule (HP:0200039)1.97132216
134Hemoptysis (HP:0002105)1.96813358
135Beaking of vertebral bodies (HP:0004568)1.96041620
136Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.95054484
137Ketoacidosis (HP:0001993)1.94464661
138CNS demyelination (HP:0007305)1.93696586
139Cerebral inclusion bodies (HP:0100314)1.93681598
140Peripheral demyelination (HP:0011096)1.93188396
141Chronic mucocutaneous candidiasis (HP:0002728)1.93058099
142Recurrent cutaneous fungal infections (HP:0011370)1.93058099
143Metabolic acidosis (HP:0001942)1.92904558
144Exercise intolerance (HP:0003546)1.91967612
145Multicystic kidney dysplasia (HP:0000003)1.90202991
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89701991
147Long clavicles (HP:0000890)1.87483968
148Glucose intolerance (HP:0000833)1.86397777
149Cardiomegaly (HP:0001640)1.86387334
150Oligohydramnios (HP:0001562)1.86015060
151Abnormality of the lumbar spine (HP:0100712)1.85957973
152Abnormality of the thoracic spine (HP:0100711)1.85567226
153Malnutrition (HP:0004395)1.85394943
154Thoracolumbar scoliosis (HP:0002944)1.84377694
155Bone pain (HP:0002653)1.83536698
156Cellulitis (HP:0100658)1.83405343
157Elevated erythrocyte sedimentation rate (HP:0003565)1.82902863
158Asymmetric septal hypertrophy (HP:0001670)1.82765029
159Supranuclear gaze palsy (HP:0000605)1.82555137
160Vasculitis (HP:0002633)1.82281153
161Severe global developmental delay (HP:0011344)1.81272702
162Tubulointerstitial abnormality (HP:0001969)1.80720536
163Progressive visual loss (HP:0000529)1.79229195
164Recurrent viral infections (HP:0004429)1.77973898
165Microtia (HP:0008551)1.76557062
166Increased serum lactate (HP:0002151)1.76378388
167Keratoconjunctivitis sicca (HP:0001097)1.76117929
168Epileptiform EEG discharges (HP:0011182)1.75767335
169Overfolded helix (HP:0000396)1.75289457
170Abnormality of serine family amino acid metabolism (HP:0010894)1.74703454
171Abnormality of glycine metabolism (HP:0010895)1.74703454
172Synostosis involving the elbow (HP:0003938)1.73842735
173Humeroradial synostosis (HP:0003041)1.73842735
174Memory impairment (HP:0002354)1.73077433
175Hypsarrhythmia (HP:0002521)1.73072885
176Gastrointestinal infarctions (HP:0005244)1.72879972
177Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71613683
178Abnormality of the nasal mucosa (HP:0000433)1.70844549
179Aplasia/Hypoplasia of the scapulae (HP:0006713)1.70519810
180Hypoplastic scapulae (HP:0000882)1.70519810
181Hypoplasia of the fovea (HP:0007750)1.70056640
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.70056640
183Lactic acidosis (HP:0003128)1.70056556
184EEG with generalized epileptiform discharges (HP:0011198)1.70004073
185Hypoplastic nipples (HP:0002557)1.69795508
186Leukodystrophy (HP:0002415)1.69602900
187Arterial thrombosis (HP:0004420)1.69524227
188Nephritis (HP:0000123)1.69086403
189Encephalitis (HP:0002383)1.68923406
190Opisthotonus (HP:0002179)1.67506503
191Increased circulating renin level (HP:0000848)1.67353907
192Epistaxis (HP:0000421)1.67239238
193Turricephaly (HP:0000262)1.66171791
194Pancreatic fibrosis (HP:0100732)1.64044270
195Cystic liver disease (HP:0006706)1.62778965
196Abnormality of the lacrimal duct (HP:0011481)1.61699379
197Optic disc pallor (HP:0000543)1.61599141
198Neoplasm of the oral cavity (HP:0100649)1.61375534
199Abnormality of fatty-acid metabolism (HP:0004359)1.59999491
200Microretrognathia (HP:0000308)1.59673715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.97181113
2PNCK4.17424304
3TESK23.54066999
4IRAK33.46994498
5BLK3.25573493
6MAPKAPK33.20541123
7BUB13.02136170
8MAP3K142.93538672
9EEF2K2.83077322
10EPHA22.75761170
11IRAK42.71983978
12TGFBR22.69836084
13ERN12.66642144
14MAP3K112.65576624
15MAP3K132.62276941
16ZAK2.53987678
17BCKDK2.52373621
18RIPK42.45822449
19TYK22.26994909
20TBK12.21218932
21TAOK22.11779665
22RPS6KB22.03421079
23GRK72.02087884
24MATK2.00100943
25TAOK11.89905381
26CSK1.88793696
27NTRK31.84864644
28PRPF4B1.84632791
29PAK31.82940678
30STK161.81319955
31MAP4K11.81033629
32LATS21.79962409
33STK38L1.78146227
34MAPK151.76872770
35FGR1.73384436
36MAP2K31.71372742
37MAPK131.70163533
38FES1.69823153
39IKBKB1.64889883
40PLK31.62157514
41ARAF1.58515813
42ACVR1B1.55867129
43CSF1R1.48050657
44CSNK1G21.46709948
45EIF2AK31.46333960
46DDR21.45832043
47VRK11.45110467
48JAK31.44814316
49MAPKAPK51.44062442
50LMTK21.41445175
51CAMK1D1.38846119
52CAMKK21.37347324
53NEK11.36716151
54MAP2K41.36507556
55ABL21.32227508
56PHKG21.30636522
57PHKG11.30636522
58RIPK11.27419576
59MAP2K21.25473250
60TNIK1.20341237
61TTK1.18851976
62MAP3K21.15560166
63MAP3K31.15268092
64ZAP701.12369153
65PDK41.12169305
66PDK31.12169305
67DYRK21.11571286
68PTK21.11257460
69IKBKE1.11065328
70MAP2K61.09145008
71MARK11.08403987
72BRAF1.07125952
73UHMK11.06334466
74LYN1.06155505
75SYK1.04125404
76TESK11.03997156
77MOS1.02640416
78TXK1.00972901
79MAP3K10.99608304
80SIK30.98589635
81MINK10.87908894
82MAP2K10.87801763
83TNK20.87679684
84EPHA40.86702052
85GRK60.86648595
86ADRBK20.85852966
87HCK0.85580400
88AURKA0.84828804
89CDC42BPA0.83431163
90SMG10.81504127
91CSNK1E0.81406168
92MARK30.81145484
93KIT0.78195614
94NME10.76720774
95SIK10.75406632
96BTK0.75400253
97PRKCG0.74698793
98NLK0.73130442
99PDPK10.70249315
100LCK0.69801226
101PLK10.69161762
102ICK0.68089742
103BCR0.67732971
104PRKCI0.67132878
105LATS10.66654692
106MST40.65932307
107GRK50.65112222
108TGFBR10.64339902
109CHUK0.63503026
110MAP2K70.61376714
111PAK40.60607514
112TSSK60.60438504
113RPS6KC10.59909538
114RPS6KL10.59909538
115INSRR0.59510211
116CSNK2A20.58238273
117MAP3K50.58080659
118JAK20.57251645
119PIM20.57015313
120ADRBK10.56825714
121WNK30.54949335
122PASK0.52533303
123MAP3K60.52412224
124TRIB30.52403143
125PDK20.51594836
126STK390.49402661
127TRPM70.48909168
128CSNK1G30.48250654
129IRAK20.48112415
130DAPK10.47862963
131RPS6KA60.47487411
132CAMK1G0.46534280
133EIF2AK20.46499147
134ERBB30.46488382
135PRKACA0.46061371
136PRKD20.45718007
137BMPR20.45451071
138CDK40.45162118
139NME20.45042310
140STK100.44945047
141MAP3K40.44698761
142MAPK40.44651616
143STK40.44395108
144PLK20.43834233
145TEC0.43135281
146WEE10.43047703
147PRKCE0.43044294
148RPS6KA20.43002096
149RPS6KB10.42753432
150CDK60.42161615
151KDR0.40823895
152TLK10.40582674
153MAP3K80.40173569
154PDK10.40119096
155TAOK30.40079655
156CAMK2G0.39868842
157CSNK2A10.39834001
158CAMK2B0.39770189
159SIK20.39674259
160CAMKK10.39275409
161ILK0.38850414
162NEK20.38460924
163TIE10.37690075
164ERBB20.36135628
165MAPK120.35728559
166JAK10.35210242
167MARK20.35068404
168MYLK0.34541713
169IRAK10.33363818
170PBK0.32513796
171CSNK1A1L0.31689196
172PRKCD0.31110804
173ITK0.30842871
174NEK90.30713946
175PIM10.30638932
176MAPK70.29556914
177CAMK2D0.29493364
178YES10.29425334
179DYRK1B0.29415648
180MELK0.28525194
181ABL10.28251641

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.94470112
2Lysosome_Homo sapiens_hsa041423.83397403
3Oxidative phosphorylation_Homo sapiens_hsa001903.61840644
4Staphylococcus aureus infection_Homo sapiens_hsa051503.36217942
5RNA polymerase_Homo sapiens_hsa030203.26418219
6Collecting duct acid secretion_Homo sapiens_hsa049663.22405517
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.94526874
8Osteoclast differentiation_Homo sapiens_hsa043802.87035688
9Parkinsons disease_Homo sapiens_hsa050122.78668618
10Leishmaniasis_Homo sapiens_hsa051402.73835746
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54666599
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35755481
13Asthma_Homo sapiens_hsa053102.34653174
14Tuberculosis_Homo sapiens_hsa051522.34210941
15Allograft rejection_Homo sapiens_hsa053302.29612688
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26294229
17Vitamin B6 metabolism_Homo sapiens_hsa007502.22418456
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10194785
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05058980
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02154966
21Huntingtons disease_Homo sapiens_hsa050162.01858291
22Graft-versus-host disease_Homo sapiens_hsa053322.00693385
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00496142
24Pertussis_Homo sapiens_hsa051332.00260383
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.94530440
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.92278111
27Autoimmune thyroid disease_Homo sapiens_hsa053201.90733137
28Phagosome_Homo sapiens_hsa041451.85298400
29Vibrio cholerae infection_Homo sapiens_hsa051101.85158038
30Alzheimers disease_Homo sapiens_hsa050101.83620783
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82459165
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.79848325
33Pyruvate metabolism_Homo sapiens_hsa006201.79771587
34Antigen processing and presentation_Homo sapiens_hsa046121.79589849
35Malaria_Homo sapiens_hsa051441.78009989
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77288229
37Sulfur metabolism_Homo sapiens_hsa009201.77180671
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71918582
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71547967
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70315028
41Pyrimidine metabolism_Homo sapiens_hsa002401.64599823
42Propanoate metabolism_Homo sapiens_hsa006401.59598082
43Legionellosis_Homo sapiens_hsa051341.59549211
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59051510
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56909458
46Salmonella infection_Homo sapiens_hsa051321.56795372
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.54358972
48Peroxisome_Homo sapiens_hsa041461.54301077
49Ribosome_Homo sapiens_hsa030101.52492211
50Synaptic vesicle cycle_Homo sapiens_hsa047211.51428033
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50384492
52TNF signaling pathway_Homo sapiens_hsa046681.50169045
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.49557816
54Fatty acid degradation_Homo sapiens_hsa000711.48273426
55Type I diabetes mellitus_Homo sapiens_hsa049401.46659361
56Toxoplasmosis_Homo sapiens_hsa051451.45642347
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44110744
58Butanoate metabolism_Homo sapiens_hsa006501.42376767
59Biosynthesis of amino acids_Homo sapiens_hsa012301.40321349
60Hematopoietic cell lineage_Homo sapiens_hsa046401.39764261
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.38899909
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.35734696
63beta-Alanine metabolism_Homo sapiens_hsa004101.35480561
64B cell receptor signaling pathway_Homo sapiens_hsa046621.33487522
65Fructose and mannose metabolism_Homo sapiens_hsa000511.31515508
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30452667
67Carbon metabolism_Homo sapiens_hsa012001.29882600
68Influenza A_Homo sapiens_hsa051641.28530567
69Proteasome_Homo sapiens_hsa030501.27848062
70Folate biosynthesis_Homo sapiens_hsa007901.24947061
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23606927
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23208271
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22814483
74Taste transduction_Homo sapiens_hsa047421.21248289
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18362772
76Chemical carcinogenesis_Homo sapiens_hsa052041.17053786
77Prion diseases_Homo sapiens_hsa050201.16243986
78Glutathione metabolism_Homo sapiens_hsa004801.10967255
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10747361
80Viral myocarditis_Homo sapiens_hsa054161.10309778
81Herpes simplex infection_Homo sapiens_hsa051681.09476863
82Complement and coagulation cascades_Homo sapiens_hsa046101.08548780
83Cardiac muscle contraction_Homo sapiens_hsa042601.06476855
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04827156
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03576296
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02202367
87Purine metabolism_Homo sapiens_hsa002301.01941726
88Mismatch repair_Homo sapiens_hsa034301.00548240
89Galactose metabolism_Homo sapiens_hsa000520.97379264
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96518708
91Fatty acid metabolism_Homo sapiens_hsa012120.96319445
92Pentose phosphate pathway_Homo sapiens_hsa000300.95944678
93Shigellosis_Homo sapiens_hsa051310.95871369
94Retinol metabolism_Homo sapiens_hsa008300.94222687
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94082587
96Chemokine signaling pathway_Homo sapiens_hsa040620.93566805
97African trypanosomiasis_Homo sapiens_hsa051430.92323609
98Metabolic pathways_Homo sapiens_hsa011000.90389655
99Spliceosome_Homo sapiens_hsa030400.88034312
100Acute myeloid leukemia_Homo sapiens_hsa052210.86893024
101Bladder cancer_Homo sapiens_hsa052190.86718234
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.84591436
103PPAR signaling pathway_Homo sapiens_hsa033200.84365682
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84267353
105Glycerolipid metabolism_Homo sapiens_hsa005610.84231553
106Primary immunodeficiency_Homo sapiens_hsa053400.83939993
107Apoptosis_Homo sapiens_hsa042100.81884436
108Sphingolipid metabolism_Homo sapiens_hsa006000.81269169
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79787433
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78957891
111Hepatitis C_Homo sapiens_hsa051600.78813707
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78551209
113Mineral absorption_Homo sapiens_hsa049780.78452017
114Measles_Homo sapiens_hsa051620.75565324
115Phenylalanine metabolism_Homo sapiens_hsa003600.74521443
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74271879
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73686427
118Fatty acid elongation_Homo sapiens_hsa000620.73408799
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.72890362
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72703125
121Amoebiasis_Homo sapiens_hsa051460.71726850
122Tryptophan metabolism_Homo sapiens_hsa003800.70946640
123Fatty acid biosynthesis_Homo sapiens_hsa000610.69838829
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67245048
125Tyrosine metabolism_Homo sapiens_hsa003500.67082143
126Arginine biosynthesis_Homo sapiens_hsa002200.67055393
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.65134472
128Hepatitis B_Homo sapiens_hsa051610.64830975
129Arginine and proline metabolism_Homo sapiens_hsa003300.64451386
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63986381
131Starch and sucrose metabolism_Homo sapiens_hsa005000.63374402
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.62919130
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.57122319
134Sulfur relay system_Homo sapiens_hsa041220.57091289
135Serotonergic synapse_Homo sapiens_hsa047260.56586398
136DNA replication_Homo sapiens_hsa030300.56517803
137Histidine metabolism_Homo sapiens_hsa003400.56007059
138RNA transport_Homo sapiens_hsa030130.54402178
139Endocytosis_Homo sapiens_hsa041440.52384461
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51666806
141Fat digestion and absorption_Homo sapiens_hsa049750.51455421
142Leukocyte transendothelial migration_Homo sapiens_hsa046700.47341300
143T cell receptor signaling pathway_Homo sapiens_hsa046600.46382426
144Renin-angiotensin system_Homo sapiens_hsa046140.46350440
145Epstein-Barr virus infection_Homo sapiens_hsa051690.46233550
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46111948
147One carbon pool by folate_Homo sapiens_hsa006700.45973431
148Non-homologous end-joining_Homo sapiens_hsa034500.44213949
149Insulin secretion_Homo sapiens_hsa049110.43155288
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43136987
151Linoleic acid metabolism_Homo sapiens_hsa005910.42930562
152Vitamin digestion and absorption_Homo sapiens_hsa049770.42460288
153VEGF signaling pathway_Homo sapiens_hsa043700.39924336
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38684683
155Nicotine addiction_Homo sapiens_hsa050330.38514859
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36752063
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35230333
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34813211
159Systemic lupus erythematosus_Homo sapiens_hsa053220.34660422
160Rheumatoid arthritis_Homo sapiens_hsa053230.33832748
161Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33560923
162Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33278338
163Circadian entrainment_Homo sapiens_hsa047130.31646453
164GABAergic synapse_Homo sapiens_hsa047270.31438393
165HIF-1 signaling pathway_Homo sapiens_hsa040660.30954167
166HTLV-I infection_Homo sapiens_hsa051660.30401134
167Arachidonic acid metabolism_Homo sapiens_hsa005900.30329721
168Neurotrophin signaling pathway_Homo sapiens_hsa047220.30075159
169Amphetamine addiction_Homo sapiens_hsa050310.29421614
170Dopaminergic synapse_Homo sapiens_hsa047280.29188350
171Homologous recombination_Homo sapiens_hsa034400.29110510
172RNA degradation_Homo sapiens_hsa030180.28841004
173Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27445428
174Wnt signaling pathway_Homo sapiens_hsa043100.26716269
175Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26478952
176Prolactin signaling pathway_Homo sapiens_hsa049170.25948144
177Nucleotide excision repair_Homo sapiens_hsa034200.25303069
178Tight junction_Homo sapiens_hsa045300.24648443
179Pancreatic cancer_Homo sapiens_hsa052120.24308751
180Platelet activation_Homo sapiens_hsa046110.23916855
181Chronic myeloid leukemia_Homo sapiens_hsa052200.20476554
182Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19576378
183Notch signaling pathway_Homo sapiens_hsa043300.19222714
184Insulin resistance_Homo sapiens_hsa049310.17110535
185Non-small cell lung cancer_Homo sapiens_hsa052230.14920772
186Viral carcinogenesis_Homo sapiens_hsa052030.10749163
187Phospholipase D signaling pathway_Homo sapiens_hsa040720.10708900
188Glycerophospholipid metabolism_Homo sapiens_hsa005640.09420015

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