PRSS37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.92248154
2* binding of sperm to zona pellucida (GO:0007339)9.87199195
3axonemal dynein complex assembly (GO:0070286)9.74185719
4cilium or flagellum-dependent cell motility (GO:0001539)9.70861726
5spermatid development (GO:0007286)9.62181723
6epithelial cilium movement (GO:0003351)9.60182883
7motile cilium assembly (GO:0044458)9.57170779
8regulation of cilium movement (GO:0003352)8.48181076
9cilium movement (GO:0003341)7.80832162
10single fertilization (GO:0007338)7.72049847
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.35617965
12piRNA metabolic process (GO:0034587)7.12461138
13sperm capacitation (GO:0048240)7.11462043
14male meiosis (GO:0007140)7.10785825
15synaptonemal complex organization (GO:0070193)6.92107404
16negative regulation of inclusion body assembly (GO:0090084)6.81729184
17synaptonemal complex assembly (GO:0007130)6.78401769
18spermatogenesis (GO:0007283)6.65204087
19protein targeting to Golgi (GO:0000042)6.63514974
20microtubule depolymerization (GO:0007019)6.63161433
21male gamete generation (GO:0048232)6.62783062
22rRNA methylation (GO:0031167)6.61405045
23fertilization (GO:0009566)6.45125343
24establishment of protein localization to Golgi (GO:0072600)6.44707074
25organic cation transport (GO:0015695)6.42013545
26retrograde transport, vesicle recycling within Golgi (GO:0000301)6.16138181
27gamete generation (GO:0007276)6.11852592
28phosphatidylethanolamine biosynthetic process (GO:0006646)5.83822555
29regulation of inclusion body assembly (GO:0090083)5.71310430
30centriole replication (GO:0007099)5.61102738
31calcium ion-dependent exocytosis (GO:0017156)5.60574183
32rRNA modification (GO:0000154)5.57429881
33cellular ketone body metabolic process (GO:0046950)5.49449207
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.39324786
35phosphatidylethanolamine metabolic process (GO:0046337)5.38612820
36germ cell development (GO:0007281)5.36352800
37spermatid nucleus differentiation (GO:0007289)5.20057631
38chromosome condensation (GO:0030261)5.05040293
39ventricular system development (GO:0021591)5.03580831
40positive regulation of Rab GTPase activity (GO:0032851)4.99704120
41regulation of Rab GTPase activity (GO:0032313)4.99704120
42regulation of microtubule-based movement (GO:0060632)4.95909005
43glycerol ether metabolic process (GO:0006662)4.93921598
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88340333
45* cell recognition (GO:0008037)4.87627522
46ketone body metabolic process (GO:1902224)4.84014020
47multicellular organismal reproductive process (GO:0048609)4.81667983
48microtubule severing (GO:0051013)4.75199947
49DNA packaging (GO:0006323)4.74959262
50regulation of centriole replication (GO:0046599)4.71832930
51protein localization to Golgi apparatus (GO:0034067)4.71438534
52male meiosis I (GO:0007141)4.70846675
53chromosome organization involved in meiosis (GO:0070192)4.66314476
54DNA methylation involved in gamete generation (GO:0043046)4.60835982
55chromatin silencing (GO:0006342)4.58155711
56ether metabolic process (GO:0018904)4.56425403
57regulation of transcription involved in cell fate commitment (GO:0060850)4.40691939
58seminiferous tubule development (GO:0072520)4.33539929
59coenzyme catabolic process (GO:0009109)4.27721890
60meiotic nuclear division (GO:0007126)4.24523457
61chaperone-mediated protein complex assembly (GO:0051131)4.16457282
62left/right pattern formation (GO:0060972)4.07330654
63single strand break repair (GO:0000012)3.87948146
64multicellular organismal development (GO:0007275)3.86287806
65negative regulation of Rho protein signal transduction (GO:0035024)3.79197211
66meiosis I (GO:0007127)3.76350390
67sexual reproduction (GO:0019953)3.74289989
68glomerular visceral epithelial cell development (GO:0072015)3.66876983
69musculoskeletal movement (GO:0050881)3.57029267
70multicellular organismal movement (GO:0050879)3.57029267
71protein polyglutamylation (GO:0018095)3.50722178
72glomerular epithelial cell development (GO:0072310)3.49998299
73microtubule polymerization or depolymerization (GO:0031109)3.48904749
74monoubiquitinated protein deubiquitination (GO:0035520)3.47048232
75regulation of spindle checkpoint (GO:0090231)3.40859839
76meiotic cell cycle (GO:0051321)3.40255327
77genitalia morphogenesis (GO:0035112)3.38353140
78cerebral cortex neuron differentiation (GO:0021895)3.34327845
79protein K11-linked deubiquitination (GO:0035871)3.33089742
80histone H3-K9 demethylation (GO:0033169)3.32784865
81sequestering of actin monomers (GO:0042989)3.31525868
82peptidyl-threonine dephosphorylation (GO:0035970)3.28996948
83microtubule nucleation (GO:0007020)3.25902700
84cranial nerve morphogenesis (GO:0021602)3.24761799
85cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19411784
86protein localization to cilium (GO:0061512)3.15702009
87carnitine transport (GO:0015879)3.14170642
88amino-acid betaine transport (GO:0015838)3.14170642
89detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.12381213
90nucleosome disassembly (GO:0006337)3.11818886
91protein-DNA complex disassembly (GO:0032986)3.11818886
92protein depolymerization (GO:0051261)3.11107654
93regulation of somitogenesis (GO:0014807)3.10216250
94protein refolding (GO:0042026)3.10158286
95negative regulation of gene expression, epigenetic (GO:0045814)3.08223594
96nucleus organization (GO:0006997)3.05745363
97polyol catabolic process (GO:0046174)3.05183114
98glycolytic process (GO:0006096)3.02967061
99regulation of interleukin-13 production (GO:0032656)3.02602142
100carnitine transmembrane transport (GO:1902603)2.96335436
101mitotic sister chromatid cohesion (GO:0007064)2.95797813
102response to acidic pH (GO:0010447)2.95700340
103cellular response to pH (GO:0071467)2.95277960
104membrane protein intracellular domain proteolysis (GO:0031293)2.94626381
105alditol metabolic process (GO:0019400)2.93956932
106nucleoside diphosphate phosphorylation (GO:0006165)2.93134825
107mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92877543
108mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92877543
109positive regulation of macrophage activation (GO:0043032)2.90328414
110NAD biosynthetic process (GO:0009435)2.87757484
111cell differentiation involved in metanephros development (GO:0072202)2.86485656
112negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.86009537
113DNA conformation change (GO:0071103)2.82997352
114regulation of T-helper 2 cell differentiation (GO:0045628)2.82972252
115homeostasis of number of cells within a tissue (GO:0048873)2.81937689
116positive regulation of action potential (GO:0045760)2.80446592
117cilium organization (GO:0044782)2.80318604
118synapsis (GO:0007129)2.78935230
119metanephric nephron tubule development (GO:0072234)2.76891754
120metanephric tubule development (GO:0072170)2.76891754
121interferon-gamma secretion (GO:0072643)2.76720643
122cilium morphogenesis (GO:0060271)2.75479669
123meiotic cell cycle process (GO:1903046)2.75311609
124centriole assembly (GO:0098534)2.74148365
125microtubule-based movement (GO:0007018)2.73747089
126GTP biosynthetic process (GO:0006183)2.72200922
127cellular component assembly involved in morphogenesis (GO:0010927)2.70744805
128cilium assembly (GO:0042384)2.70479309
129intraciliary transport (GO:0042073)2.68278455
130RNA localization (GO:0006403)2.66410053
131axoneme assembly (GO:0035082)2.64610630
132lactate metabolic process (GO:0006089)2.63812635
133regulation of cilium assembly (GO:1902017)2.63021063
134gene silencing by RNA (GO:0031047)2.61779225
135RNA destabilization (GO:0050779)2.59401437
136polyamine biosynthetic process (GO:0006596)2.51909992
137glycerol metabolic process (GO:0006071)2.49204817
138peptidyl-glutamic acid modification (GO:0018200)2.46701053
139negative regulation of organelle assembly (GO:1902116)2.45794422
140UTP biosynthetic process (GO:0006228)2.41636198
141fusion of sperm to egg plasma membrane (GO:0007342)14.3063811
142cell wall macromolecule metabolic process (GO:0044036)14.1341007
143cell wall macromolecule catabolic process (GO:0016998)14.1341007
144sperm motility (GO:0030317)13.6061271
145acrosome reaction (GO:0007340)12.0162788
146acrosome assembly (GO:0001675)11.9823472
147multicellular organism reproduction (GO:0032504)11.6880763
148* sperm-egg recognition (GO:0035036)11.3848514
149plasma membrane fusion (GO:0045026)10.9036029
150response to pheromone (GO:0019236)10.2315534
151* cell-cell recognition (GO:0009988)10.1554962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.46908744
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.13908218
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.83146034
4EZH2_22144423_ChIP-Seq_EOC_Human3.73140355
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.71531374
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.40480242
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.26380846
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90576752
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88596031
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51487977
11VDR_22108803_ChIP-Seq_LS180_Human2.43757238
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.33682918
13FUS_26573619_Chip-Seq_HEK293_Human2.27298341
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22991340
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.12223963
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.09402861
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08291493
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05554091
19ZNF274_21170338_ChIP-Seq_K562_Hela2.03684563
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.01246344
21* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.96712382
22ER_23166858_ChIP-Seq_MCF-7_Human1.94878477
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.91522359
24ERA_21632823_ChIP-Seq_H3396_Human1.90725105
25DROSHA_22980978_ChIP-Seq_HELA_Human1.85517058
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82333267
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.82173664
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81805930
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.81252063
30RAC3_21632823_ChIP-Seq_H3396_Human1.79456141
31STAT1_17558387_ChIP-Seq_HELA_Human1.78103109
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77174278
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.76514988
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.72203438
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70344241
36P300_19829295_ChIP-Seq_ESCs_Human1.66898142
37NANOG_20526341_ChIP-Seq_ESCs_Human1.66144951
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.65189807
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.64120518
40* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62483437
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62075683
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.60837366
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.60116917
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.59462792
45SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59293395
46WDR5_24793694_ChIP-Seq_LNCAP_Human1.57421671
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.57169144
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.56848142
49AR_25329375_ChIP-Seq_VCAP_Human1.56112721
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.55766575
51MYC_19829295_ChIP-Seq_ESCs_Human1.55464469
52TP53_18474530_ChIP-ChIP_U2OS_Human1.55338386
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54412495
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.54271467
55TAF2_19829295_ChIP-Seq_ESCs_Human1.53713098
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52414008
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.52143884
58* KDM2B_26808549_Chip-Seq_REH_Human1.50921678
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44569503
60CTCF_27219007_Chip-Seq_Bcells_Human1.41369140
61CBP_20019798_ChIP-Seq_JUKART_Human1.41194368
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41194368
63LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.40853975
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.37779207
65OCT4_20526341_ChIP-Seq_ESCs_Human1.36984508
66CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36276387
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35451403
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35126160
69ETV1_20927104_ChIP-Seq_GIST48_Human1.35120001
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.34323735
71GATA3_21867929_ChIP-Seq_TH1_Mouse1.33486764
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.33288053
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.33179532
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32952176
75E2F1_20622854_ChIP-Seq_HELA_Human1.32867449
76RBPJ_21746931_ChIP-Seq_IB4_Human1.32244358
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.31872593
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31466707
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31405181
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31041437
81* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30282866
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.29048505
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29025091
84P53_21459846_ChIP-Seq_SAOS-2_Human1.28703794
85BCL6_27268052_Chip-Seq_Bcells_Human1.28644141
86RUNX2_22187159_ChIP-Seq_PCA_Human1.28179731
87* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27551038
88GF1_26923725_Chip-Seq_HPCs_Mouse1.27395769
89CTCF_20526341_ChIP-Seq_ESCs_Human1.25134691
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24903801
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24758673
92SMAD4_21799915_ChIP-Seq_A2780_Human1.24015100
93REST_21632747_ChIP-Seq_MESCs_Mouse1.23926466
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23893523
95TBL1_22424771_ChIP-Seq_293T_Human1.23842091
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23532788
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23192999
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.22027403
99TP63_19390658_ChIP-ChIP_HaCaT_Human1.21719379
100SMC4_20622854_ChIP-Seq_HELA_Human1.20380537
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20075914
102PHF8_20622854_ChIP-Seq_HELA_Human1.20027059
103KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19849327
104STAT3_23295773_ChIP-Seq_U87_Human1.19702011
105NANOG_19829295_ChIP-Seq_ESCs_Human1.19029827
106SOX2_19829295_ChIP-Seq_ESCs_Human1.19029827
107CEBPB_22108803_ChIP-Seq_LS180_Human1.18766410
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18631884
109TP63_22573176_ChIP-Seq_HFKS_Human1.18396207
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.18032356
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17653073
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17164892
113PHF8_20622853_ChIP-Seq_HELA_Human1.16618647
114SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15347459
115AR_21572438_ChIP-Seq_LNCaP_Human1.14453887
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.13841956
117CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12968390
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12563405
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.11971724
120RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11357304
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10536183
122E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09663583
123BCOR_27268052_Chip-Seq_Bcells_Human1.08852995
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08601786
125HOXB7_26014856_ChIP-Seq_BT474_Human1.08584032
126ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08552034
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08272812
128* SPI1_26923725_Chip-Seq_HPCs_Mouse1.08045026
129P300_27268052_Chip-Seq_Bcells_Human1.07776923
130PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07316797
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07300440
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06961044
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06961044
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06367773
135EZH2_27294783_Chip-Seq_ESCs_Mouse1.06122930
136SMRT_27268052_Chip-Seq_Bcells_Human1.05970744
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.05780545
138GATA6_21074721_ChIP-Seq_CACO-2_Human1.05778059
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05761268
140P68_20966046_ChIP-Seq_HELA_Human1.05446994
141NFYA_21822215_ChIP-Seq_K562_Human1.05292664
142BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04870586
143TAF15_26573619_Chip-Seq_HEK293_Human1.04197692
144ESET_19884257_ChIP-Seq_ESCs_Mouse1.03021511
145* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02712813
146P53_22387025_ChIP-Seq_ESCs_Mouse1.02073506
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01031597
148ERG_20517297_ChIP-Seq_VCAP_Human1.01004577
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00808987
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00377880
151RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00321370
152NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00316041
153RNF2_27304074_Chip-Seq_NSC_Mouse1.00278210
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99966931
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99824324
156CMYC_18555785_Chip-Seq_ESCs_Mouse0.99768281
157MYC_27129775_Chip-Seq_CORNEA_Mouse0.99280578
158GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99121389
159LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98423879
160KLF4_18555785_Chip-Seq_ESCs_Mouse0.98044405
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97816260
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.96808736
163P300_18555785_Chip-Seq_ESCs_Mouse0.95415503
164SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95218772
165ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94945994
166GF1B_26923725_Chip-Seq_HPCs_Mouse0.94661605
167PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92142675
168* RARA_24833708_ChIP-Seq_LIVER_Mouse0.91854384
169NFYB_21822215_ChIP-Seq_K562_Human0.91470685
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91189499
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.90956712
172NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90207463
173SOX9_26525672_Chip-Seq_HEART_Mouse0.89535195
174SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89512928
175STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89499613

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05347313
2MP0001929_abnormal_gametogenesis5.57331910
3MP0008877_abnormal_DNA_methylation4.22055543
4MP0002210_abnormal_sex_determination3.41690834
5MP0002161_abnormal_fertility/fecundity3.33169308
6MP0001348_abnormal_lacrimal_gland3.19379785
7MP0005670_abnormal_white_adipose2.91883095
8MP0001145_abnormal_male_reproductive2.89657452
9MP0002653_abnormal_ependyma_morphology2.65394681
10MP0000678_abnormal_parathyroid_gland2.60751356
11MP0000653_abnormal_sex_gland2.55281169
12MP0003718_maternal_effect2.11487286
13MP0005248_abnormal_Harderian_gland2.10494017
14MP0005423_abnormal_somatic_nervous2.02075653
15MP0005410_abnormal_fertilization16.4158477
16MP0001486_abnormal_startle_reflex1.98308363
17MP0004859_abnormal_synaptic_plasticity1.77386403
18MP0003646_muscle_fatigue1.72915943
19MP0001485_abnormal_pinna_reflex1.71395670
20MP0004233_abnormal_muscle_weight1.67876751
21MP0005379_endocrine/exocrine_gland_phen1.63233395
22MP0002132_abnormal_respiratory_system1.61629046
23MP0002160_abnormal_reproductive_system1.48611785
24MP0005623_abnormal_meninges_morphology1.46648365
25MP0002735_abnormal_chemical_nociception1.40528637
26MP0002249_abnormal_larynx_morphology1.39935356
27MP0009053_abnormal_anal_canal1.38550584
28MP0002282_abnormal_trachea_morphology1.30267707
29MP0005310_abnormal_salivary_gland1.28973875
30MP0001963_abnormal_hearing_physiology1.28623357
31MP0004510_myositis1.17969418
32MP0000026_abnormal_inner_ear1.16617870
33MP0001984_abnormal_olfaction1.11914534
34MP0001765_abnormal_ion_homeostasis1.11844024
35MP0002127_abnormal_cardiovascular_syste1.11736002
36MP0002234_abnormal_pharynx_morphology1.08894161
37MP0002067_abnormal_sensory_capabilities1.08727930
38MP0003880_abnormal_central_pattern0.99730019
39MP0005395_other_phenotype0.97908773
40MP0000049_abnormal_middle_ear0.97693592
41MP0006292_abnormal_olfactory_placode0.97414643
42MP0002733_abnormal_thermal_nociception0.94616925
43MP0009046_muscle_twitch0.94231483
44MP0005167_abnormal_blood-brain_barrier0.92828730
45MP0005647_abnormal_sex_gland0.92581213
46MP0002229_neurodegeneration0.91805693
47MP0000681_abnormal_thyroid_gland0.89595888
48MP0000955_abnormal_spinal_cord0.88508520
49MP0008058_abnormal_DNA_repair0.87909167
50MP0002572_abnormal_emotion/affect_behav0.84340333
51MP0002272_abnormal_nervous_system0.80983381
52MP0002822_catalepsy0.79313682
53MP0001905_abnormal_dopamine_level0.78589176
54MP0004085_abnormal_heartbeat0.77415125
55MP0005389_reproductive_system_phenotype0.76793512
56MP0002557_abnormal_social/conspecific_i0.76470820
57MP0002138_abnormal_hepatobiliary_system0.74940195
58MP0002734_abnormal_mechanical_nocicepti0.74904693
59MP0002102_abnormal_ear_morphology0.74628174
60MP0008569_lethality_at_weaning0.74245128
61MP0001970_abnormal_pain_threshold0.74105805
62MP0008995_early_reproductive_senescence0.73595710
63MP0009745_abnormal_behavioral_response0.73435906
64MP0005451_abnormal_body_composition0.72970637
65MP0003119_abnormal_digestive_system0.71003271
66MP0003011_delayed_dark_adaptation0.70476510
67MP0003635_abnormal_synaptic_transmissio0.70242371
68MP0003115_abnormal_respiratory_system0.69607343
69MP0001879_abnormal_lymphatic_vessel0.67765101
70MP0003137_abnormal_impulse_conducting0.64232895
71MP0005636_abnormal_mineral_homeostasis0.60673542
72MP0001529_abnormal_vocalization0.60156078
73MP0005408_hypopigmentation0.60031406
74MP0010094_abnormal_chromosome_stability0.59139956
75MP0003699_abnormal_female_reproductive0.56115559
76MP0005666_abnormal_adipose_tissue0.54907015
77MP0004270_analgesia0.53865557
78MP0009697_abnormal_copulation0.52983199
79MP0005083_abnormal_biliary_tract0.51646444
80MP0002882_abnormal_neuron_morphology0.50987888
81MP0001501_abnormal_sleep_pattern0.50431535
82MP0005377_hearing/vestibular/ear_phenot0.50366177
83MP0003878_abnormal_ear_physiology0.50366177
84MP0004484_altered_response_of0.50196248
85MP0001440_abnormal_grooming_behavior0.50008975
86MP0001324_abnormal_eye_pigmentation0.49933654
87MP0002269_muscular_atrophy0.49802553
88MP0003077_abnormal_cell_cycle0.49538787
89MP0006276_abnormal_autonomic_nervous0.48740446
90MP0003329_amyloid_beta_deposits0.48697769
91MP0000516_abnormal_urinary_system0.46680276
92MP0005367_renal/urinary_system_phenotyp0.46680276
93MP0008789_abnormal_olfactory_epithelium0.46551808
94MP0002928_abnormal_bile_duct0.46289924
95MP0002184_abnormal_innervation0.46289680
96MP0004036_abnormal_muscle_relaxation0.46082823
97MP0000566_synostosis0.45437272
98MP0001764_abnormal_homeostasis0.43218555
99MP0002064_seizures0.42833595
100MP0001293_anophthalmia0.42510440
101MP0005253_abnormal_eye_physiology0.42408864
102MP0000358_abnormal_cell_content/0.42219276
103MP0005551_abnormal_eye_electrophysiolog0.41973583
104MP0001119_abnormal_female_reproductive0.41007262
105MP0003950_abnormal_plasma_membrane0.40774120
106MP0002752_abnormal_somatic_nervous0.39854103
107MP0003936_abnormal_reproductive_system0.39229020
108MP0002736_abnormal_nociception_after0.38988757
109MP0005646_abnormal_pituitary_gland0.38558062
110MP0000569_abnormal_digit_pigmentation0.37680828
111MP0000534_abnormal_ureter_morphology0.36729655
112MP0003111_abnormal_nucleus_morphology0.35907332
113MP0009115_abnormal_fat_cell0.35796575
114MP0005397_hematopoietic_system_phenotyp0.32838818
115MP0001545_abnormal_hematopoietic_system0.32838818
116MP0002971_abnormal_brown_adipose0.32094454
117MP0006036_abnormal_mitochondrial_physio0.29997496
118MP0003942_abnormal_urinary_system0.29629445
119MP0005391_vision/eye_phenotype0.29199379
120MP0009278_abnormal_bone_marrow0.27619573
121MP0003786_premature_aging0.27365303
122MP0002139_abnormal_hepatobiliary_system0.27302553
123MP0003633_abnormal_nervous_system0.26667782
124MP0004133_heterotaxia0.26456375
125MP0001730_embryonic_growth_arrest0.26247879
126MP0003861_abnormal_nervous_system0.25011945
127MP0004811_abnormal_neuron_physiology0.23110015
128MP0003879_abnormal_hair_cell0.22618798
129MP0000604_amyloidosis0.22549451
130MP0010307_abnormal_tumor_latency0.21894320
131MP0002152_abnormal_brain_morphology0.20651196
132MP0004019_abnormal_vitamin_homeostasis0.20141545
133MP0003631_nervous_system_phenotype0.19704831
134MP0001968_abnormal_touch/_nociception0.18844306
135MP0002169_no_abnormal_phenotype0.18815010
136MP0008875_abnormal_xenobiotic_pharmacok0.18770409
137MP0002873_normal_phenotype0.18636742
138MP0002295_abnormal_pulmonary_circulatio0.18325433
139MP0002084_abnormal_developmental_patter0.17101119
140MP0008057_abnormal_DNA_replication0.16852856
141MP0006072_abnormal_retinal_apoptosis0.16063596
142MP0003948_abnormal_gas_homeostasis0.15631061
143MP0008961_abnormal_basal_metabolism0.15353321
144MP0001986_abnormal_taste_sensitivity0.15299486
145MP0008007_abnormal_cellular_replicative0.15249707
146MP0004145_abnormal_muscle_electrophysio0.14823049
147MP0002405_respiratory_system_inflammati0.14533682
148MP0006035_abnormal_mitochondrial_morpho0.14288403
149MP0000313_abnormal_cell_death0.14284835
150MP0001697_abnormal_embryo_size0.14059134
151MP0005195_abnormal_posterior_eye0.13627566
152MP0005503_abnormal_tendon_morphology0.13624926
153MP0004742_abnormal_vestibular_system0.13612885
154MP0004808_abnormal_hematopoietic_stem0.13094711
155MP0000001_mammalian_phenotype0.12544227
156MP0005319_abnormal_enzyme/_coenzyme0.12123033
157MP0009250_abnormal_appendicular_skeleto0.12006945
158MP0003787_abnormal_imprinting0.11952491
159MP0001672_abnormal_embryogenesis/_devel0.11824108
160MP0005380_embryogenesis_phenotype0.11824108
161MP0000462_abnormal_digestive_system0.11769319
162MP0005535_abnormal_body_temperature0.11714845
163MP0000432_abnormal_head_morphology0.11651065
164MP0004043_abnormal_pH_regulation0.11108773

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.38300537
2Abnormal respiratory motile cilium morphology (HP:0005938)9.24065448
3Abnormal respiratory epithelium morphology (HP:0012253)9.24065448
4Severe visual impairment (HP:0001141)8.05069885
5Rhinitis (HP:0012384)7.58086567
6Abnormal ciliary motility (HP:0012262)7.43735536
7Chronic bronchitis (HP:0004469)7.38684837
8Infertility (HP:0000789)6.83746041
9Nasal polyposis (HP:0100582)6.39370753
10Abnormality of the nasal mucosa (HP:0000433)5.24560519
11Attenuation of retinal blood vessels (HP:0007843)5.04070191
12Bony spicule pigmentary retinopathy (HP:0007737)4.89574253
13Male infertility (HP:0003251)4.87117535
14Bronchitis (HP:0012387)4.59613010
15Bronchiectasis (HP:0002110)4.43845509
16Chronic hepatic failure (HP:0100626)4.33383743
17Abnormality of macular pigmentation (HP:0008002)4.28150540
18Resting tremor (HP:0002322)4.03938036
19Nephronophthisis (HP:0000090)3.98281558
20Abnormal rod and cone electroretinograms (HP:0008323)3.92526309
21Cone-rod dystrophy (HP:0000548)3.91860752
22Hypoplastic ischia (HP:0003175)3.87792202
23Hyperkalemia (HP:0002153)3.70029140
24Abnormal spermatogenesis (HP:0008669)3.68797248
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.60906997
26Potter facies (HP:0002009)3.53618770
27Facial shape deformation (HP:0011334)3.53618770
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.52964021
29Abnormality of the ischium (HP:0003174)3.43002863
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.39204903
31Recurrent sinusitis (HP:0011108)3.37055267
32Enlarged epiphyses (HP:0010580)3.30441004
33Recurrent otitis media (HP:0000403)3.28368323
34Abnormality of the renal medulla (HP:0100957)2.99369454
35Hypoplasia of the thymus (HP:0000778)2.97265977
36Abnormality of the parathyroid morphology (HP:0011766)2.87136187
37Medial flaring of the eyebrow (HP:0010747)2.86197483
38Abnormality of the aortic arch (HP:0012303)2.85401497
39Progressive sensorineural hearing impairment (HP:0000408)2.80729184
40Recurrent bronchitis (HP:0002837)2.73565125
41Unilateral renal agenesis (HP:0000122)2.66014621
42Impulsivity (HP:0100710)2.65979642
43Tubulointerstitial nephritis (HP:0001970)2.61357232
44Amelogenesis imperfecta (HP:0000705)2.56374047
45Abnormality of midbrain morphology (HP:0002418)2.56202992
46Molar tooth sign on MRI (HP:0002419)2.56202992
47Progressive cerebellar ataxia (HP:0002073)2.54329252
48Truncal obesity (HP:0001956)2.52143425
49Hypoalphalipoproteinemia (HP:0003233)2.47278860
50Tubular atrophy (HP:0000092)2.46442647
51Postural instability (HP:0002172)2.44540013
52Azoospermia (HP:0000027)2.42825868
53Generalized aminoaciduria (HP:0002909)2.41544387
54Abnormality of potassium homeostasis (HP:0011042)2.36985779
55Insulin-resistant diabetes mellitus (HP:0000831)2.31867526
56Abnormality of the pubic bones (HP:0003172)2.28377288
57Tubulointerstitial abnormality (HP:0001969)2.26864943
58Abnormality of dental color (HP:0011073)2.21302671
59Cholecystitis (HP:0001082)2.20175411
60Abnormal gallbladder physiology (HP:0012438)2.20175411
61Gonadotropin excess (HP:0000837)2.19177366
62Tetany (HP:0001281)2.17739485
63Polyuria (HP:0000103)2.17543795
64Abnormality of the costochondral junction (HP:0000919)2.16466798
65Mixed hearing impairment (HP:0000410)2.14224811
66Renovascular hypertension (HP:0100817)2.13936073
67Portal hypertension (HP:0001409)2.13501852
68Pendular nystagmus (HP:0012043)2.12292592
69Oligodactyly (hands) (HP:0001180)2.11723647
70Horizontal nystagmus (HP:0000666)2.11335971
71Optic nerve hypoplasia (HP:0000609)2.09511944
72Abnormality of the epiphysis of the femoral head (HP:0010574)2.05980087
73Menstrual irregularities (HP:0000858)2.03373087
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03272797
75Epiphyseal dysplasia (HP:0002656)2.02558842
76Dyschromatopsia (HP:0007641)2.02349030
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.3495796
78Absent/shortened dynein arms (HP:0200106)13.3495796
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2163838
80Osteomalacia (HP:0002749)1.99378468
81Atonic seizures (HP:0010819)1.98162781
82Hyponatremia (HP:0002902)1.95241085
83Abnormality of the hepatic vasculature (HP:0006707)1.92796407
84Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.90982114
85Abnormality of femoral epiphyses (HP:0006499)1.90982114
86Upper limb muscle weakness (HP:0003484)1.89841796
87Decreased central vision (HP:0007663)1.85169635
88Tubulointerstitial fibrosis (HP:0005576)1.85066520
89Congenital primary aphakia (HP:0007707)1.83707997
90Gait imbalance (HP:0002141)1.83120578
91Spastic tetraparesis (HP:0001285)1.82849136
92Myokymia (HP:0002411)1.82813264
93Abnormality of the femoral head (HP:0003368)1.82616444
94Ventricular tachycardia (HP:0004756)1.82538405
95Choroideremia (HP:0001139)1.76756972
96Flattened epiphyses (HP:0003071)1.76752111
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76452196
98Focal segmental glomerulosclerosis (HP:0000097)1.75175026
99Aplasia/Hypoplasia of the lens (HP:0008063)1.74713390
100Heterotopia (HP:0002282)1.74508497
101Sclerocornea (HP:0000647)1.73810993
102Keratoconus (HP:0000563)1.73755253
103Increased corneal curvature (HP:0100692)1.73755253
104Postaxial foot polydactyly (HP:0001830)1.73488727
105Intellectual disability, moderate (HP:0002342)1.72838198
106Progressive hearing impairment (HP:0001730)1.72668638
107Bradycardia (HP:0001662)1.72626966
108Hypoparathyroidism (HP:0000829)1.71585910
109Stage 5 chronic kidney disease (HP:0003774)1.68218061
110Congenital hepatic fibrosis (HP:0002612)1.64435053
111Abnormal drinking behavior (HP:0030082)1.64086637
112Polydipsia (HP:0001959)1.64086637
113Chronic sinusitis (HP:0011109)1.60830066
114Short ribs (HP:0000773)1.56786982
115Nephrogenic diabetes insipidus (HP:0009806)1.55314691
116Abnormality of the renal cortex (HP:0011035)1.55032121
117Abnormality of renal excretion (HP:0011036)1.53995762
118Postaxial hand polydactyly (HP:0001162)1.53081144
119Bile duct proliferation (HP:0001408)1.51621349
120Abnormal biliary tract physiology (HP:0012439)1.51621349
121Hemorrhage of the eye (HP:0011885)1.49887313
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49388583
123Absent epiphyses (HP:0010577)1.49388583
124Oculomotor apraxia (HP:0000657)1.47122168
125Easy fatigability (HP:0003388)1.46494081
126Renal dysplasia (HP:0000110)1.45480590
127Facial cleft (HP:0002006)1.44958950
128Bell-shaped thorax (HP:0001591)1.44378540
129Fibular hypoplasia (HP:0003038)1.44151373
130Vaginal atresia (HP:0000148)1.41437636
131Abnormality of permanent molar morphology (HP:0011071)1.41276867
132Abnormality of the dental root (HP:0006486)1.41276867
133Taurodontia (HP:0000679)1.41276867
134Genital tract atresia (HP:0001827)1.40653762
135Fatigable weakness (HP:0003473)1.39857187
136Abnormality of the neuromuscular junction (HP:0003398)1.39857187
137Poor coordination (HP:0002370)1.38023261
138Double outlet right ventricle (HP:0001719)1.37190973
139Congenital malformation of the right heart (HP:0011723)1.37190973
140Neurofibrillary tangles (HP:0002185)1.36535390
141Abnormality of saccadic eye movements (HP:0000570)1.36398419
142Cerebellar dysplasia (HP:0007033)1.36210392
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.35406867
144Asymmetric septal hypertrophy (HP:0001670)1.34838699
145Abnormality of dentin (HP:0010299)1.34253199
146Cystic liver disease (HP:0006706)1.30513446
147Abnormality of the dental pulp (HP:0006479)1.30459105
148Abnormality of molar morphology (HP:0011070)1.30332856
149Abnormality of molar (HP:0011077)1.30332856
150Bundle branch block (HP:0011710)1.29250970
151Short femoral neck (HP:0100864)1.28797331
152Pancreatic fibrosis (HP:0100732)1.27977920
153Microglossia (HP:0000171)1.26873350
154Deformed sella turcica (HP:0002681)1.26365936
155Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.25573441
156Abnormal urine output (HP:0012590)1.24768543
157Sensory axonal neuropathy (HP:0003390)1.21877766
158Abnormality of ocular smooth pursuit (HP:0000617)1.20963115
159Abnormality of the lower motor neuron (HP:0002366)1.20745330
160Absent frontal sinuses (HP:0002688)1.20224250
161Supernumerary spleens (HP:0009799)1.19581698
162Type 2 muscle fiber atrophy (HP:0003554)1.19312161
163Hemiparesis (HP:0001269)1.18766167
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.17460982
165Short thorax (HP:0010306)1.13971642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.10625704
2PDK38.10625704
3TESK16.24870581
4PRKD35.25182451
5PDK25.23391802
6MAP4K25.05443245
7DDR24.65475123
8ICK4.47633371
9INSRR4.27753828
10PLK23.22532907
11BRD43.15563357
12MAP3K42.68439019
13PTK2B2.26564310
14WNK42.14527914
15STK392.06650780
16STK381.83706130
17PNCK1.81270735
18PIK3CG1.79107188
19NEK21.62182968
20MST1R1.60826445
21DYRK1B1.53589473
22CDK71.31329098
23AKT31.30094700
24FRK1.23075316
25PDK11.18749722
26BMPR1B1.02773883
27MARK10.99953382
28KSR20.97698181
29TYRO30.94034582
30MAP2K70.91280154
31CASK0.90055937
32UHMK10.87033138
33CAMK1D0.84514483
34IRAK10.83344622
35DYRK30.80008717
36TESK20.77112299
37TTK0.75865654
38WNK30.74887813
39WNK10.74172407
40PDPK10.73618244
41EEF2K0.73171378
42MAPK150.73047471
43CHEK20.72268032
44STK30.71556536
45PLK40.69319310
46MAP3K90.67196919
47PASK0.66349352
48RIPK40.65979009
49MUSK0.65773482
50CCNB10.65596523
51PRKAA20.64111706
52LMTK20.60350220
53STK38L0.59075479
54CAMK10.58882320
55MAP2K60.55711910
56LATS20.54565395
57MAP3K20.52750282
58CAMK1G0.50513341
59ROCK10.49824407
60CAMK40.49354814
61ACVR1B0.48303485
62PINK10.47823357
63MAP3K110.45373944
64CHEK10.42581639
65PAK10.42113106
66CDK30.40249548
67IRAK20.40224110
68MAPK10.40177726
69LATS10.40038822
70TNIK0.39762566
71NTRK20.39265658
72CDK120.38166031
73TRIM280.37698576
74WEE10.36132065
75SGK2230.35351169
76SGK4940.35351169
77BRSK20.34636693
78RPS6KA20.34496334
79ADRBK20.33236707
80OXSR10.33128526
81MAP2K20.32250406
82MET0.31765582
83SIK20.31660268
84MKNK20.31580065
85PRKCG0.30780682
86MAPKAPK50.29983419
87SGK10.29147706
88ATM0.28601059
89MAPK100.27807221
90PAK20.26943358
91TIE10.26156363
92MARK20.25621322
93BRAF0.25452363
94MAP3K80.25280350
95MAPK140.25159565
96MTOR0.24512203
97NTRK30.24267270
98MAP2K40.23719298
99ATR0.23029141
100PRKCE0.22430838
101MINK10.22354744
102CAMKK10.21959482
103CDC70.20943852
104PLK10.20890228
105PRKAA10.20857005
106BRSK10.20443465
107MAP3K100.20129560
108AKT10.18952772
109PAK40.18554833
110NEK60.18379082
111PRKACB0.18131703
112MAP3K70.17543898
113PRKG20.16659496
114ERBB30.16562225
115MAPK130.15535743
116RPS6KA60.15346362
117CDK150.15067278
118ZAK0.14109154
119BLK0.13879562
120PRKCZ0.12735219
121RPS6KB10.12703785
122STK100.12625283
123CDK180.12294412
124PRKCQ0.11724093
125CDK11A0.10796467
126YES10.09886524
127PKN10.08959374
128RPS6KA10.07833536
129CSNK2A10.07765261
130RIPK10.07052949
131CDK140.06862342
132MARK30.06485170
133GSK3B0.06279403
134PRKG10.06172929
135CSNK1D0.04795406
136STK110.04220918
137CDK20.03515064
138EGFR0.03317676
139CDK10.03256886
140CDK60.03147314
141CAMK2A0.02895681
142TAOK10.02739348
143AURKA0.02538713
144PRKACG0.02484637
145CSNK2A20.02352474
146PDGFRB0.02211982
147ZAP700.01916672
148CSF1R0.01436809
149PAK60.00913315
150MAP3K50.00745729
151MAPK80.00738522
152PRKCD0.00411577
153PRKCA0.00307945
154PRKACA-0.0373822
155PRKDC-0.0325556
156PIM1-0.0155941
157PRKCB-0.0066760
158CDK4-0.0055625

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.66254924
2Fatty acid biosynthesis_Homo sapiens_hsa000614.54415334
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.49004099
4Olfactory transduction_Homo sapiens_hsa047404.02328066
5Vitamin B6 metabolism_Homo sapiens_hsa007503.79913347
6Pyruvate metabolism_Homo sapiens_hsa006203.47303580
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.05826769
8Linoleic acid metabolism_Homo sapiens_hsa005912.96789599
9Butanoate metabolism_Homo sapiens_hsa006502.94581804
10Propanoate metabolism_Homo sapiens_hsa006402.76874418
11Basal transcription factors_Homo sapiens_hsa030222.60691758
12Glucagon signaling pathway_Homo sapiens_hsa049222.56296120
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.56065917
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25826019
15Nicotine addiction_Homo sapiens_hsa050332.23973880
16Selenocompound metabolism_Homo sapiens_hsa004502.08644906
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06538354
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01208537
19Glycerolipid metabolism_Homo sapiens_hsa005612.00858086
20Pentose phosphate pathway_Homo sapiens_hsa000301.96218974
21PPAR signaling pathway_Homo sapiens_hsa033201.91449905
22Oocyte meiosis_Homo sapiens_hsa041141.79243420
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.74100016
24Type II diabetes mellitus_Homo sapiens_hsa049301.67705166
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.62808570
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.61586852
27Mineral absorption_Homo sapiens_hsa049781.54860917
28Fructose and mannose metabolism_Homo sapiens_hsa000511.50950327
29Type I diabetes mellitus_Homo sapiens_hsa049401.47428681
30Amphetamine addiction_Homo sapiens_hsa050311.46756273
31Dorso-ventral axis formation_Homo sapiens_hsa043201.46172904
32Phototransduction_Homo sapiens_hsa047441.45807908
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45264803
34Phenylalanine metabolism_Homo sapiens_hsa003601.45250124
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44885944
36Allograft rejection_Homo sapiens_hsa053301.43240302
37Fanconi anemia pathway_Homo sapiens_hsa034601.41121776
38Autoimmune thyroid disease_Homo sapiens_hsa053201.40820660
39Morphine addiction_Homo sapiens_hsa050321.40298544
40Ether lipid metabolism_Homo sapiens_hsa005651.39601477
41Carbon metabolism_Homo sapiens_hsa012001.37649843
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35625079
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34334745
44Graft-versus-host disease_Homo sapiens_hsa053321.32868544
45Fat digestion and absorption_Homo sapiens_hsa049751.32018816
46Fatty acid metabolism_Homo sapiens_hsa012121.28478105
47Arginine and proline metabolism_Homo sapiens_hsa003301.28100182
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27934620
49Fatty acid degradation_Homo sapiens_hsa000711.25490692
50Cardiac muscle contraction_Homo sapiens_hsa042601.24391020
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.24042558
52Huntingtons disease_Homo sapiens_hsa050161.08841765
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08578917
54Renin secretion_Homo sapiens_hsa049241.05924613
55Purine metabolism_Homo sapiens_hsa002301.05759431
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99833045
57Collecting duct acid secretion_Homo sapiens_hsa049660.99304589
58Antigen processing and presentation_Homo sapiens_hsa046120.98706499
59GABAergic synapse_Homo sapiens_hsa047270.98671229
60Glutathione metabolism_Homo sapiens_hsa004800.97413148
61RNA transport_Homo sapiens_hsa030130.96811777
62mRNA surveillance pathway_Homo sapiens_hsa030150.96783355
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95671736
64Biosynthesis of amino acids_Homo sapiens_hsa012300.95008523
65Viral myocarditis_Homo sapiens_hsa054160.91089477
66Glutamatergic synapse_Homo sapiens_hsa047240.90878224
67Hedgehog signaling pathway_Homo sapiens_hsa043400.89093027
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87910799
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.82633704
70Insulin secretion_Homo sapiens_hsa049110.79002533
71Renin-angiotensin system_Homo sapiens_hsa046140.77227493
72Chemical carcinogenesis_Homo sapiens_hsa052040.77029322
73Arachidonic acid metabolism_Homo sapiens_hsa005900.75461432
74Estrogen signaling pathway_Homo sapiens_hsa049150.72155238
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.71455358
76Thyroid hormone synthesis_Homo sapiens_hsa049180.71185645
77Retinol metabolism_Homo sapiens_hsa008300.68117906
78Long-term potentiation_Homo sapiens_hsa047200.67773062
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67455717
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.67437234
81Bile secretion_Homo sapiens_hsa049760.66640511
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65829114
83Serotonergic synapse_Homo sapiens_hsa047260.63777791
84Systemic lupus erythematosus_Homo sapiens_hsa053220.57186784
85Legionellosis_Homo sapiens_hsa051340.56119924
86Protein digestion and absorption_Homo sapiens_hsa049740.55912690
87Arginine biosynthesis_Homo sapiens_hsa002200.55674012
88Synaptic vesicle cycle_Homo sapiens_hsa047210.53055956
89Tyrosine metabolism_Homo sapiens_hsa003500.51067923
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50795384
91Influenza A_Homo sapiens_hsa051640.48940218
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.48754961
93Calcium signaling pathway_Homo sapiens_hsa040200.47860621
94Pancreatic secretion_Homo sapiens_hsa049720.46451445
95Inositol phosphate metabolism_Homo sapiens_hsa005620.44993688
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44747666
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44456883
98Salivary secretion_Homo sapiens_hsa049700.43836201
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40851600
100ABC transporters_Homo sapiens_hsa020100.40617279
101Endocytosis_Homo sapiens_hsa041440.39791620
102Metabolic pathways_Homo sapiens_hsa011000.39653625
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.39501937
104AMPK signaling pathway_Homo sapiens_hsa041520.39276858
105N-Glycan biosynthesis_Homo sapiens_hsa005100.36927049
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36668031
107Gastric acid secretion_Homo sapiens_hsa049710.35576499
108MAPK signaling pathway_Homo sapiens_hsa040100.35558678
109Cholinergic synapse_Homo sapiens_hsa047250.35422283
110VEGF signaling pathway_Homo sapiens_hsa043700.33364765
111Nitrogen metabolism_Homo sapiens_hsa009100.31986608
112Taste transduction_Homo sapiens_hsa047420.31390881
113Pyrimidine metabolism_Homo sapiens_hsa002400.30792336
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.30632762
115cAMP signaling pathway_Homo sapiens_hsa040240.30381789
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30245329
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30017207
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29368521
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27970847
120Cocaine addiction_Homo sapiens_hsa050300.26981352
121Alcoholism_Homo sapiens_hsa050340.23105182
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.23097527
123Tight junction_Homo sapiens_hsa045300.22724938
124Tryptophan metabolism_Homo sapiens_hsa003800.22183118
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21697621
126Oxytocin signaling pathway_Homo sapiens_hsa049210.20685950
127Circadian entrainment_Homo sapiens_hsa047130.20596063
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19559626
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18780153
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18540245
131Sulfur metabolism_Homo sapiens_hsa009200.18439816
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17242993
133RNA degradation_Homo sapiens_hsa030180.12716714
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12273410
135Wnt signaling pathway_Homo sapiens_hsa043100.10947084
136Cell cycle_Homo sapiens_hsa041100.09605587
137Salmonella infection_Homo sapiens_hsa051320.08811465
138B cell receptor signaling pathway_Homo sapiens_hsa046620.07828818
139Basal cell carcinoma_Homo sapiens_hsa052170.07345550

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