PRSS3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Although this locus appears to encode a protein similar to trypsinogen, the locus is thought to be a transcribed pseudogene. ESTs support its transcription, but expression of its predicted protein has not been observed. Its predicted protein sequence differs significantly from the known functional trypsinogens, including a different amino acid at the conserved residue 122 which is important for autolysis. This pseudogene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycolipid catabolic process (GO:0019377)9.34034879
2membrane lipid catabolic process (GO:0046466)8.58000153
3negative regulation of epidermis development (GO:0045683)8.20296411
4protein retention in ER lumen (GO:0006621)7.99093323
5neutrophil mediated immunity (GO:0002446)7.86060896
6peptidyl-proline hydroxylation (GO:0019511)7.55489566
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.21420855
8arachidonic acid secretion (GO:0050482)7.05298881
9icosanoid secretion (GO:0032309)7.05298881
10phosphatidylinositol acyl-chain remodeling (GO:0036149)7.04352763
11phosphatidylserine acyl-chain remodeling (GO:0036150)6.67279693
12sterol catabolic process (GO:0016127)6.65084539
13cholesterol catabolic process (GO:0006707)6.65084539
14phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.61931137
15ceramide catabolic process (GO:0046514)6.49342534
16tetrapyrrole metabolic process (GO:0033013)6.13211329
17regulation of keratinocyte differentiation (GO:0045616)5.96320270
18protein hydroxylation (GO:0018126)5.88311624
19icosanoid transport (GO:0071715)5.85250867
20fatty acid derivative transport (GO:1901571)5.85250867
21myeloid leukocyte mediated immunity (GO:0002444)5.69109607
22regulation of keratinocyte proliferation (GO:0010837)5.58485246
23daunorubicin metabolic process (GO:0044597)5.55571185
24polyketide metabolic process (GO:0030638)5.55571185
25doxorubicin metabolic process (GO:0044598)5.55571185
26innate immune response in mucosa (GO:0002227)5.38328393
27leukotriene biosynthetic process (GO:0019370)5.17604449
28aminoglycoside antibiotic metabolic process (GO:0030647)5.05475090
29sterol transport (GO:0015918)4.79775629
30cholesterol transport (GO:0030301)4.79775629
31phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.78019831
32digestive system process (GO:0022600)4.66956100
33phospholipid catabolic process (GO:0009395)4.53765813
34water-soluble vitamin metabolic process (GO:0006767)4.47096657
35cellular protein catabolic process (GO:0044257)4.44021740
36mucosal immune response (GO:0002385)4.41443755
37phosphatidylserine metabolic process (GO:0006658)4.39424348
38sphingolipid catabolic process (GO:0030149)4.32004072
39antibacterial humoral response (GO:0019731)4.23887690
40phosphatidylcholine acyl-chain remodeling (GO:0036151)4.09083334
41organ or tissue specific immune response (GO:0002251)4.00534473
42acute-phase response (GO:0006953)3.93314680
43antimicrobial humoral response (GO:0019730)3.89961042
44phosphatidic acid metabolic process (GO:0046473)3.83890837
45phosphatidic acid biosynthetic process (GO:0006654)3.83890837
46defense response to Gram-positive bacterium (GO:0050830)3.75888661
47leukotriene metabolic process (GO:0006691)3.64297899
48alditol phosphate metabolic process (GO:0052646)3.62233267
49regulation of epidermal cell differentiation (GO:0045604)3.57268079
50regulation of acrosome reaction (GO:0060046)3.44686674
51negative regulation of epithelial cell differentiation (GO:0030857)3.43221764
52vitamin metabolic process (GO:0006766)3.41943260
53mitochondrial calcium ion transport (GO:0006851)3.41572590
54regulation of cholesterol homeostasis (GO:2000188)3.21871580
55multicellular organismal catabolic process (GO:0044243)3.19747684
56retinoid metabolic process (GO:0001523)3.17638968
57positive regulation of wound healing (GO:0090303)3.14833924
58steroid catabolic process (GO:0006706)3.11216395
59phosphatidylglycerol metabolic process (GO:0046471)3.07003067
60diterpenoid metabolic process (GO:0016101)3.00276372
61intestinal cholesterol absorption (GO:0030299)24.3386452
62nucleotide-sugar biosynthetic process (GO:0009226)2.99655860
63multicellular organismal metabolic process (GO:0044236)2.97666932
64extracellular matrix disassembly (GO:0022617)2.95085599
65L-alpha-amino acid transmembrane transport (GO:1902475)2.89357885
66phototransduction, visible light (GO:0007603)2.85556708
67regulation of triglyceride catabolic process (GO:0010896)2.83953104
68fatty acid derivative biosynthetic process (GO:1901570)2.79491822
69icosanoid biosynthetic process (GO:0046456)2.79491822
70maintenance of protein localization in organelle (GO:0072595)2.77007331
71regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.77003447
72cholesterol metabolic process (GO:0008203)2.75013828
73glycoside metabolic process (GO:0016137)2.70814950
74progesterone metabolic process (GO:0042448)2.70746970
75acute inflammatory response (GO:0002526)2.70048022
76calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.68499727
77terpenoid metabolic process (GO:0006721)2.62729335
78atrioventricular valve morphogenesis (GO:0003181)2.58633673
79primary alcohol catabolic process (GO:0034310)2.57283824
80sterol metabolic process (GO:0016125)2.47719971
81macroautophagy (GO:0016236)2.43340877
82alcohol catabolic process (GO:0046164)2.41810801
83long-chain fatty acid transport (GO:0015909)2.41104813
84detection of visible light (GO:0009584)2.39496950
85lipid catabolic process (GO:0016042)2.35800878
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.33044338
87exocrine pancreas development (GO:0031017)2.30057906
88isoprenoid metabolic process (GO:0006720)2.26590659
89maintenance of gastrointestinal epithelium (GO:0030277)2.26518398
90phototransduction (GO:0007602)2.25266829
91unsaturated fatty acid biosynthetic process (GO:0006636)2.22210974
92glutathione derivative biosynthetic process (GO:1901687)2.22089010
93glutathione derivative metabolic process (GO:1901685)2.22089010
94regulation of epidermis development (GO:0045682)2.20038626
95digestion (GO:0007586)19.2063290
96cobalamin metabolic process (GO:0009235)18.1917200
97transcytosis (GO:0045056)12.3383412
98intestinal absorption (GO:0050892)11.3088831
99regulation of phospholipase A2 activity (GO:0032429)11.2000204
100negative regulation of epidermal cell differentiation (GO:0045605)10.7931710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.61166012
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.61166012
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.61166012
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.38667060
5EGR1_19032775_ChIP-ChIP_M12_Human2.80281506
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74146720
7GATA4_25053715_ChIP-Seq_YYC3_Human2.66356972
8PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.37890863
9HTT_18923047_ChIP-ChIP_STHdh_Human2.12993347
10GATA6_25053715_ChIP-Seq_YYC3_Human2.02518855
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat15.2590970
12ESR1_21235772_ChIP-Seq_MCF-7_Human1.90825982
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.88954973
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84884198
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.82641499
16PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.66794024
17TCF4_18268006_ChIP-ChIP_LS174T_Human1.66625335
18ETV1_20927104_ChIP-Seq_GIST48_Human1.62603132
19HNFA_21074721_ChIP-Seq_CACO-2_Human1.58828142
20PHF8_20622853_ChIP-Seq_HELA_Human1.56051318
21NFYA_21822215_ChIP-Seq_K562_Human1.55947857
22PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.55278792
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.53001959
24CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.52203802
25GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.49787480
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.48367168
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.47389663
28RBPJ_21746931_ChIP-Seq_IB4_Human1.47167571
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46404795
30SOX2_20726797_ChIP-Seq_SW620_Human1.45926165
31CBX2_22325352_ChIP-Seq_293T-Rex_Human1.44655762
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44466953
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.43317738
34FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38569920
35FOXA1_25552417_ChIP-Seq_VCAP_Human1.38316001
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37618544
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36475789
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36143522
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35969526
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34938499
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32758900
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.28210408
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.27784385
44NFYB_21822215_ChIP-Seq_K562_Human1.27065173
45ESET_19884257_ChIP-Seq_ESCs_Mouse1.24131842
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20705676
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19059636
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15643276
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13591228
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13114037
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10836005
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05060512
53GATA1_22025678_ChIP-Seq_K562_Human1.04579349
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.03041131
55TAF2_19829295_ChIP-Seq_ESCs_Human0.96479750
56CEBPB_22108803_ChIP-Seq_LS180_Human0.96045072
57TBL1_22424771_ChIP-Seq_293T_Human0.95991473
58GATA3_24758297_ChIP-Seq_MCF-7_Human0.94657323
59FOXA2_19822575_ChIP-Seq_HepG2_Human0.91516718
60EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91138102
61CBP_21632823_ChIP-Seq_H3396_Human0.90113004
62P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90012505
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86960371
64SMAD4_21741376_ChIP-Seq_EPCs_Human0.86806856
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85521467
66FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85235768
67CJUN_26792858_Chip-Seq_BT549_Human0.84901426
68TP53_18474530_ChIP-ChIP_U2OS_Human0.83749109
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83400116
70ERA_21632823_ChIP-Seq_H3396_Human0.82831125
71FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82520036
72P300_19829295_ChIP-Seq_ESCs_Human0.82498085
73FLI1_21867929_ChIP-Seq_CD8_Mouse0.80470063
74PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78845232
75AR_20517297_ChIP-Seq_VCAP_Human0.78466654
76CDX2_22108803_ChIP-Seq_LS180_Human0.78212720
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78154863
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77381089
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.76556673
80SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75614253
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75042841
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74939842
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74211585
84FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73911857
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.73527011
86CDX2_20551321_ChIP-Seq_CACO-2_Human0.73200642
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.72980372
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72691021
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71594056
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.70823160
91LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70763415
92P300_27268052_Chip-Seq_Bcells_Human0.70584034
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70452958
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.69005957
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69005957
96SOX2_21211035_ChIP-Seq_LN229_Human0.68109897
97GATA3_21867929_ChIP-Seq_CD8_Mouse0.67283210
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.66901332
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.66901332
100LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.66471425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition9.47748923
2MP0005365_abnormal_bile_salt7.96891114
3MP0003959_abnormal_lean_body3.67428283
4MP0005220_abnormal_exocrine_pancreas3.50974072
5MP0005083_abnormal_biliary_tract3.29576667
6MP0005085_abnormal_gallbladder_physiolo2.23829692
7MP0001666_abnormal_nutrient_absorption13.4764320
8MP0010386_abnormal_urinary_bladder1.92037197
9MP0005448_abnormal_energy_balance1.86439577
10MP0002693_abnormal_pancreas_physiology1.83899186
11MP0002138_abnormal_hepatobiliary_system1.71461080
12MP0002118_abnormal_lipid_homeostasis1.63204942
13MP0005084_abnormal_gallbladder_morpholo1.60268329
14MP0003300_gastrointestinal_ulcer1.58029214
15MP0010329_abnormal_lipoprotein_level1.41791341
16MP0010234_abnormal_vibrissa_follicle1.39788004
17MP0000613_abnormal_salivary_gland1.32218545
18MP0002876_abnormal_thyroid_physiology1.28700765
19MP0005452_abnormal_adipose_tissue1.22631041
20MP0008004_abnormal_stomach_pH1.19343177
21MP0004264_abnormal_extraembryonic_tissu1.05084734
22MP0002078_abnormal_glucose_homeostasis0.97179220
23MP0009780_abnormal_chondrocyte_physiolo0.95761272
24MP0003011_delayed_dark_adaptation0.95704026
25MP0003195_calcinosis0.95008067
26MP0003953_abnormal_hormone_level0.93437331
27MP0002132_abnormal_respiratory_system0.89212409
28MP0001873_stomach_inflammation0.84551367
29MP0000598_abnormal_liver_morphology0.81994907
30MP0002928_abnormal_bile_duct0.81622379
31MP0001944_abnormal_pancreas_morphology0.80784856
32MP0002139_abnormal_hepatobiliary_system0.79066123
33MP0003943_abnormal_hepatobiliary_system0.77014079
34MP0005334_abnormal_fat_pad0.75195838
35MP0001664_abnormal_digestion0.73223694
36MP0002163_abnormal_gland_morphology0.73178614
37MP0001501_abnormal_sleep_pattern0.68703870
38MP0003045_fibrosis0.67630479
39MP0003252_abnormal_bile_duct0.67252067
40MP0009840_abnormal_foam_cell0.63498665
41MP0002277_abnormal_respiratory_mucosa0.62357968
42MP0001756_abnormal_urination0.60435257
43MP0002089_abnormal_postnatal_growth/wei0.59658461
44MP0001502_abnormal_circadian_rhythm0.59657311
45MP0001731_abnormal_postnatal_growth0.56240983
46MP0000462_abnormal_digestive_system0.55538029
47MP0002970_abnormal_white_adipose0.54039967
48MP0003879_abnormal_hair_cell0.49713169
49MP0004019_abnormal_vitamin_homeostasis0.48984550
50MP0005332_abnormal_amino_acid0.48074655
51MP0005319_abnormal_enzyme/_coenzyme0.47474869
52MP0004233_abnormal_muscle_weight0.46967601
53MP0008872_abnormal_physiological_respon0.45608653
54MP0010678_abnormal_skin_adnexa0.45189401
55MP0001845_abnormal_inflammatory_respons0.44515533
56MP0010352_gastrointestinal_tract_polyps0.42854875
57MP0003950_abnormal_plasma_membrane0.41516792
58MP0008875_abnormal_xenobiotic_pharmacok0.37086486
59MP0009643_abnormal_urine_homeostasis0.36770127
60MP0000367_abnormal_coat/_hair0.36652868
61MP0003283_abnormal_digestive_organ0.35723733
62MP0009642_abnormal_blood_homeostasis0.35193787
63MP0002909_abnormal_adrenal_gland0.35188131
64MP0008995_early_reproductive_senescence0.34758529
65MP0005377_hearing/vestibular/ear_phenot0.34752127
66MP0003878_abnormal_ear_physiology0.34752127
67MP0005379_endocrine/exocrine_gland_phen0.34408723
68MP0000470_abnormal_stomach_morphology0.33110361
69MP0005636_abnormal_mineral_homeostasis0.32619863
70MP0001765_abnormal_ion_homeostasis0.30219121
71MP0003656_abnormal_erythrocyte_physiolo0.30176307
72MP0003828_pulmonary_edema0.30000908
73MP0008961_abnormal_basal_metabolism0.29744276
74MP0003866_abnormal_defecation0.28387782
75MP0000538_abnormal_urinary_bladder0.27517024
76MP0002168_other_aberrant_phenotype0.24936126
77MP0004043_abnormal_pH_regulation0.24556988
78MP0002796_impaired_skin_barrier0.23693636
79MP0001485_abnormal_pinna_reflex0.22972980
80MP0000609_abnormal_liver_physiology0.22279514
81MP0000858_altered_metastatic_potential0.22002364
82MP0002837_dystrophic_cardiac_calcinosis0.21967568
83MP0008469_abnormal_protein_level0.21500064
84MP0005166_decreased_susceptibility_to0.20149823
85MP0003646_muscle_fatigue0.19258567
86MP0002098_abnormal_vibrissa_morphology0.18818100
87MP0005451_abnormal_body_composition0.18496131
88MP0003329_amyloid_beta_deposits0.17596006
89MP0002127_abnormal_cardiovascular_syste0.17587155
90MP0003956_abnormal_body_size0.17312913
91MP0008770_decreased_survivor_rate0.16705550
92MP0005410_abnormal_fertilization0.16576415
93MP0002136_abnormal_kidney_physiology0.16456734
94MP0002069_abnormal_eating/drinking_beha0.15684530
95MP0009763_increased_sensitivity_to0.14551820
96MP0000467_abnormal_esophagus_morphology0.14460951
97MP0001542_abnormal_bone_strength0.14154426
98MP0005595_abnormal_vascular_smooth0.13962458
99MP0005646_abnormal_pituitary_gland0.13812714
100MP0009764_decreased_sensitivity_to0.13475516

Predicted human phenotypes

RankGene SetZ-score
1Pancreatitis (HP:0001733)6.01649432
2Abnormality of the pleura (HP:0002103)4.20050025
3Tetraparesis (HP:0002273)3.59874015
4Abnormal pancreas size (HP:0012094)3.43189601
5Abnormality of proline metabolism (HP:0010907)3.12105053
6Hydroxyprolinuria (HP:0003080)3.12105053
7Anal atresia (HP:0002023)3.04919012
8Steatorrhea (HP:0002570)20.9676087
9Vascular calcification (HP:0004934)2.86453149
10Cardiovascular calcification (HP:0011915)2.48950050
11Ileus (HP:0002595)2.45886711
12Large for gestational age (HP:0001520)2.42363251
13Abnormality of the pons (HP:0007361)2.35044882
14Abnormality of glutamine family amino acid metabolism (HP:0010902)2.31518629
15Type I transferrin isoform profile (HP:0003642)2.23529885
16Abnormal sex determination (HP:0012244)2.22981335
17Sex reversal (HP:0012245)2.22981335
18Male infertility (HP:0003251)2.19563941
19Popliteal pterygium (HP:0009756)2.14936262
20Reduced antithrombin III activity (HP:0001976)2.14579282
21Type II lissencephaly (HP:0007260)2.10636605
22Tubulointerstitial fibrosis (HP:0005576)2.09913544
23Abnormality of the nasal septum (HP:0000419)2.09865066
24Abnormality of methionine metabolism (HP:0010901)2.05497218
25Rectal prolapse (HP:0002035)2.00720329
26Fat malabsorption (HP:0002630)16.1923710
27Hypoproteinemia (HP:0003075)12.4712819
28Exocrine pancreatic insufficiency (HP:0001738)12.4663324
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99365099
30Abnormal protein N-linked glycosylation (HP:0012347)1.99365099
31Abnormal protein glycosylation (HP:0012346)1.99365099
32Abnormal glycosylation (HP:0012345)1.99365099
33Congenital, generalized hypertrichosis (HP:0004540)1.94315795
34Stenosis of the external auditory canal (HP:0000402)1.82566394
35Paraparesis (HP:0002385)1.82457860
36Abnormal biliary tract morphology (HP:0012440)1.82289361
37Hypoplasia of the pons (HP:0012110)1.74958406
38Gout (HP:0001997)1.69895817
39Abnormality of the distal phalanges of the toes (HP:0010182)1.69359776
40Right ventricular cardiomyopathy (HP:0011663)1.66451081
41Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66031454
42Esophageal varix (HP:0002040)1.64835999
43Cerebellar dysplasia (HP:0007033)1.63660668
44Goiter (HP:0000853)1.62448009
45Lower limb hyperreflexia (HP:0002395)1.61119077
46Abnormality of sulfur amino acid metabolism (HP:0004339)1.60805560
47Tubulointerstitial nephritis (HP:0001970)1.59069530
48Tubulointerstitial abnormality (HP:0001969)1.58102811
49Abdominal pain (HP:0002027)1.57386291
50Insulin-resistant diabetes mellitus (HP:0000831)1.55189781
51Preauricular pit (HP:0004467)1.53188129
52Periauricular skin pits (HP:0100277)1.53188129
53Congenital malformation of the right heart (HP:0011723)1.52050606
54Double outlet right ventricle (HP:0001719)1.52050606
55Skin pits (HP:0100276)1.48852954
56Abnormality of the intrinsic pathway (HP:0010989)1.47568801
57Abnormal hemoglobin (HP:0011902)1.46937804
58Glossoptosis (HP:0000162)1.45613505
59Potter facies (HP:0002009)1.44145018
60Facial shape deformation (HP:0011334)1.44145018
61Abnormality of the renal cortex (HP:0011035)1.43203138
62Hyperinsulinemic hypoglycemia (HP:0000825)1.43021694
63Abnormality of urine glucose concentration (HP:0011016)1.40222802
64Glycosuria (HP:0003076)1.40222802
65Increased CSF protein (HP:0002922)1.39118455
66Late onset (HP:0003584)1.39026215
67Malnutrition (HP:0004395)1.37359883
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.36932158
69Barrel-shaped chest (HP:0001552)1.36732235
70Type I diabetes mellitus (HP:0100651)1.33533858
71Villous atrophy (HP:0011473)1.33439740
72Abnormality of small intestinal villus morphology (HP:0011472)1.33439740
73Hyperphosphatemia (HP:0002905)1.29714927
74Portal hypertension (HP:0001409)1.28870927
75Enlarged kidneys (HP:0000105)1.27199863
76Bifid uvula (HP:0000193)1.25921690
77Carpal bone hypoplasia (HP:0001498)1.25767102
78Hyperuricemia (HP:0002149)1.24360699
79Increased purine levels (HP:0004368)1.24360699
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.23675668
81Abnormality of alanine metabolism (HP:0010916)1.23675668
82Hyperalaninemia (HP:0003348)1.23675668
83Tubular atrophy (HP:0000092)1.23614871
84Gowers sign (HP:0003391)1.22663070
85Azoospermia (HP:0000027)1.20910722
86Ketoacidosis (HP:0001993)1.17215500
87Hyperglycemia (HP:0003074)1.16653924
88Glomerulonephritis (HP:0000099)1.16099386
89Abnormality of the hepatic vasculature (HP:0006707)1.13717003
90Abnormality of aromatic amino acid family metabolism (HP:0004338)1.13103408
91Abnormal connection of the cardiac segments (HP:0011545)1.08982717
92Abnormal ventriculo-arterial connection (HP:0011563)1.08982717
93Transposition of the great arteries (HP:0001669)1.08982717
94Hypercalciuria (HP:0002150)1.08946190
95Vertebral compression fractures (HP:0002953)1.08469943
96Abnormality of the right ventricle (HP:0001707)1.07698529
97Ureteral duplication (HP:0000073)1.04923506
98Ketosis (HP:0001946)1.04895385
99Absent eyebrow (HP:0002223)1.04388089
100Abnormality of chloride homeostasis (HP:0011422)1.04324798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.61242680
2EPHA25.28766679
3EIF2AK35.03329720
4PDK24.45036164
5MAP3K33.64205533
6TAOK32.89614418
7NME12.56513441
8MAP3K22.43089968
9GRK12.28701775
10ERN12.22048688
11STK392.06558088
12MAPKAPK32.00710561
13EPHA31.84660271
14MAP3K121.78177782
15FRK1.77674910
16INSRR1.70921910
17NTRK31.62955341
18IRAK11.62170352
19BMPR1B1.46447939
20EIF2AK11.43903022
21PRKG21.39989748
22TBK11.36985200
23MST41.33539367
24NLK1.30551409
25MST1R1.20992628
26STK241.11598628
27IRAK21.10089135
28MAPK151.09562398
29NEK61.08394897
30OXSR11.06370822
31ERBB40.95874479
32PIM20.93574275
33FER0.92836045
34STK160.89416601
35RIPK10.83504780
36SCYL20.83431026
37CDK190.79088888
38BCKDK0.78390582
39TRPM70.74326491
40SGK30.72742815
41MAP2K20.69827173
42TIE10.67964697
43ACVR1B0.65514167
44MAP3K70.64334163
45PRKCE0.64327168
46EPHB10.60914291
47DAPK20.60250725
48SGK20.59004265
49MELK0.57514990
50MAP3K50.55157163
51PASK0.55114997
52PDPK10.53962704
53STK38L0.53136490
54MAP2K10.52540949
55CDK80.49696556
56STK380.48809420
57RPS6KB20.47713438
58EEF2K0.46580744
59MAP3K40.44400514
60DAPK10.41879953
61ROCK10.41272972
62MAPK70.39152789
63MYLK0.38898252
64PRKAA10.38769252
65SGK4940.37753338
66SGK2230.37753338
67MAP3K90.37127727
68JAK10.33185235
69WNK40.31713638
70MET0.31457910
71CAMK40.31075520
72MUSK0.30087145
73LRRK20.29370114
74TAOK10.28344910
75PDK10.27813271
76CHUK0.27222063
77FGFR30.25369527
78TESK10.24940306
79ICK0.24536174
80CSNK1G10.23779019
81MAP3K140.23636430
82ZAP700.23467914
83PRKAA20.23301549
84MAP3K10.22719106
85EIF2AK20.22649054
86ERBB30.22549792
87TAOK20.22389558
88MAPK10.21179621
89FGFR40.19523362
90SRPK10.19145138
91ILK0.18291529
92ADRBK20.17902448
93RPS6KB10.16500590
94CSNK1A10.16276813
95PRKCA0.15931966
96MAPK120.15797018
97BRSK20.15762119
98TGFBR20.15142933
99DAPK30.14903660
100STK30.14813651

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049758.15708049
2Protein digestion and absorption_Homo sapiens_hsa049746.71101979
3Glycerolipid metabolism_Homo sapiens_hsa005613.82607091
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28299461
5Vitamin digestion and absorption_Homo sapiens_hsa049772.18832825
6Renin-angiotensin system_Homo sapiens_hsa046142.12880667
7Pancreatic secretion_Homo sapiens_hsa0497210.3358266
8Starch and sucrose metabolism_Homo sapiens_hsa005001.81473073
9Steroid biosynthesis_Homo sapiens_hsa001001.79948132
10Linoleic acid metabolism_Homo sapiens_hsa005911.79804367
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.73488239
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.67824808
13Ether lipid metabolism_Homo sapiens_hsa005651.11869163
14Arachidonic acid metabolism_Homo sapiens_hsa005900.92771311
15Influenza A_Homo sapiens_hsa051640.71573758
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70712701
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66287596
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63935520
19Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60088026
20Circadian rhythm_Homo sapiens_hsa047100.58628641
21Sulfur metabolism_Homo sapiens_hsa009200.56362419
22Vitamin B6 metabolism_Homo sapiens_hsa007500.53385567
23Protein export_Homo sapiens_hsa030600.52869471
24Glutathione metabolism_Homo sapiens_hsa004800.51217403
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47362402
26Cyanoamino acid metabolism_Homo sapiens_hsa004600.44896226
27Notch signaling pathway_Homo sapiens_hsa043300.43302212
28Steroid hormone biosynthesis_Homo sapiens_hsa001400.39747284
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38984217
30Chemical carcinogenesis_Homo sapiens_hsa052040.38498101
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37222548
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35655476
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35447320
34Histidine metabolism_Homo sapiens_hsa003400.35051224
35Selenocompound metabolism_Homo sapiens_hsa004500.31961427
36Glycerophospholipid metabolism_Homo sapiens_hsa005640.29763021
37N-Glycan biosynthesis_Homo sapiens_hsa005100.29098569
38Retinol metabolism_Homo sapiens_hsa008300.25263815
39Metabolic pathways_Homo sapiens_hsa011000.21785135
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21302988
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19135467
42Vibrio cholerae infection_Homo sapiens_hsa051100.17738218
43Bile secretion_Homo sapiens_hsa049760.17627703
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16287418
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16141273
46Hepatitis C_Homo sapiens_hsa051600.15605122
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15519824
48Tryptophan metabolism_Homo sapiens_hsa003800.14989108
49Tight junction_Homo sapiens_hsa045300.14313953
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.13988510
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.13759739
52Mineral absorption_Homo sapiens_hsa049780.13247366
53Fatty acid degradation_Homo sapiens_hsa000710.10984970
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10772715
55Complement and coagulation cascades_Homo sapiens_hsa046100.10234455
56Arginine and proline metabolism_Homo sapiens_hsa003300.09931251
57Sphingolipid metabolism_Homo sapiens_hsa006000.09448200
58Phototransduction_Homo sapiens_hsa047440.06984010
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.06862241
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06644315
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06167534
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05397726
63Peroxisome_Homo sapiens_hsa041460.05094711
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.04267542
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.04019135
66Butanoate metabolism_Homo sapiens_hsa006500.03499700
67beta-Alanine metabolism_Homo sapiens_hsa004100.03301541
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02371983
69Thyroid hormone synthesis_Homo sapiens_hsa049180.01345864
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.01297985
71ABC transporters_Homo sapiens_hsa020100.01221704
72HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1173631
73Folate biosynthesis_Homo sapiens_hsa00790-0.1139607
74FoxO signaling pathway_Homo sapiens_hsa04068-0.1079581
75Arginine biosynthesis_Homo sapiens_hsa00220-0.1064442
76Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.1050642
77Nitrogen metabolism_Homo sapiens_hsa00910-0.1033443
78SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.1030403
79Tyrosine metabolism_Homo sapiens_hsa00350-0.1027437
80TNF signaling pathway_Homo sapiens_hsa04668-0.1016858
81Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.0934962
82Pentose phosphate pathway_Homo sapiens_hsa00030-0.0869971
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0837175
84Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0809606
85Lysosome_Homo sapiens_hsa04142-0.0695256
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0689833
87Proteasome_Homo sapiens_hsa03050-0.0629267
88Galactose metabolism_Homo sapiens_hsa00052-0.0618451
89Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0581009
90Other glycan degradation_Homo sapiens_hsa00511-0.0561960
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0527312
92TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0521405
93Ras signaling pathway_Homo sapiens_hsa04014-0.0452683
94Insulin secretion_Homo sapiens_hsa04911-0.0297116
95Propanoate metabolism_Homo sapiens_hsa00640-0.0283686
96Regulation of autophagy_Homo sapiens_hsa04140-0.0213624
97Adherens junction_Homo sapiens_hsa04520-0.0209330
98Legionellosis_Homo sapiens_hsa05134-0.0161054
99Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0033164
100Sulfur relay system_Homo sapiens_hsa04122-0.0029998

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