PRSS42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.77774673
2actin-myosin filament sliding (GO:0033275)9.77774673
3sarcomere organization (GO:0045214)8.98341291
4cardiac myofibril assembly (GO:0055003)8.68105936
5myofibril assembly (GO:0030239)8.54896689
6actin-mediated cell contraction (GO:0070252)8.08574274
7regulation of relaxation of muscle (GO:1901077)7.97149816
8cardiac muscle contraction (GO:0060048)7.85379778
9piRNA metabolic process (GO:0034587)7.59957303
10motile cilium assembly (GO:0044458)7.48415347
11sarcoplasmic reticulum calcium ion transport (GO:0070296)7.46610011
12regulation of actin filament-based movement (GO:1903115)7.40849588
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO7.35010286
14aminoglycoside antibiotic metabolic process (GO:0030647)7.31343307
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.30606727
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)7.27521743
17sperm motility (GO:0030317)7.26129991
18acrosome reaction (GO:0007340)7.12140002
19striated muscle contraction (GO:0006941)6.81206569
20cardiac muscle hypertrophy (GO:0003300)6.79019166
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.72224321
22fusion of sperm to egg plasma membrane (GO:0007342)6.69821032
23multicellular organism reproduction (GO:0032504)6.68813529
24sperm-egg recognition (GO:0035036)6.66519146
25cardiac muscle tissue morphogenesis (GO:0055008)6.56707798
26axonemal dynein complex assembly (GO:0070286)6.49861793
27cardiac muscle cell development (GO:0055013)6.47636741
28striated muscle hypertrophy (GO:0014897)6.42644725
29regulation of the force of heart contraction (GO:0002026)6.27708239
30binding of sperm to zona pellucida (GO:0007339)6.20132813
31actomyosin structure organization (GO:0031032)6.12777044
32cardiac chamber formation (GO:0003207)6.08637348
33adult heart development (GO:0007512)6.07647831
34muscle tissue morphogenesis (GO:0060415)6.04570838
35cardiac cell development (GO:0055006)6.03332149
36male meiosis (GO:0007140)6.01717194
37actin filament-based movement (GO:0030048)5.96434449
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.93448915
39cell-cell recognition (GO:0009988)5.93201293
40ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.80244197
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.69454445
42muscle hypertrophy (GO:0014896)5.69378424
43detection of molecule of bacterial origin (GO:0032490)5.68149214
44epithelial cilium movement (GO:0003351)5.67958830
45acrosome assembly (GO:0001675)5.58834733
46cell wall macromolecule catabolic process (GO:0016998)5.44275320
47cell wall macromolecule metabolic process (GO:0044036)5.44275320
48DNA methylation involved in gamete generation (GO:0043046)5.43301714
49regulation of cardioblast differentiation (GO:0051890)5.36880475
50microtubule depolymerization (GO:0007019)5.32557233
51regulation of cell communication by electrical coupling (GO:0010649)5.28081869
52negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.26545588
53regulation of skeletal muscle contraction (GO:0014819)5.20150776
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.17384931
55spermatid development (GO:0007286)5.16731316
56reproduction (GO:0000003)5.11840509
57regulation of striated muscle contraction (GO:0006942)5.09435739
58cell communication by electrical coupling (GO:0010644)5.04913436
59cilium movement (GO:0003341)5.04617168
60plasma membrane fusion (GO:0045026)5.01129336
61ventricular cardiac muscle cell action potential (GO:0086005)4.96767448
62skeletal muscle contraction (GO:0003009)4.94010217
63response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.93634511
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.92508289
65regulation of cardiac muscle cell contraction (GO:0086004)4.88438182
66cell communication involved in cardiac conduction (GO:0086065)4.83806143
67synaptonemal complex assembly (GO:0007130)4.80475518
68bundle of His cell to Purkinje myocyte communication (GO:0086069)4.80466693
69regulation of cilium movement (GO:0003352)4.75463138
70synaptonemal complex organization (GO:0070193)4.72804023
71sulfate transport (GO:0008272)4.66583124
72relaxation of cardiac muscle (GO:0055119)4.66547269
73negative regulation of potassium ion transmembrane transport (GO:1901380)4.65586762
74regulation of acrosome reaction (GO:0060046)4.56662652
75regulation of ATP catabolic process (GO:1903289)4.53843408
76regulation of ATPase activity (GO:0043462)4.53843408
77positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.53090187
78muscle contraction (GO:0006936)4.51604451
79cardiac ventricle formation (GO:0003211)4.48422901
80single fertilization (GO:0007338)4.46110703
81atrial septum morphogenesis (GO:0060413)4.42840770
82response to inactivity (GO:0014854)4.36410638
83regulation of heart rate (GO:0002027)4.36068247
84cardiac muscle hypertrophy in response to stress (GO:0014898)4.35422382
85muscle hypertrophy in response to stress (GO:0003299)4.35422382
86cardiac muscle adaptation (GO:0014887)4.35422382
87negative regulation of keratinocyte proliferation (GO:0010839)4.31198493
88sulfate transmembrane transport (GO:1902358)4.28100803
89regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.27158828
90auditory receptor cell stereocilium organization (GO:0060088)4.25716455
91negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.19375705
92muscle system process (GO:0003012)4.12153523
93striated muscle cell development (GO:0055002)4.10114407
94heart process (GO:0003015)4.09292363
95heart contraction (GO:0060047)4.09292363
96sperm capacitation (GO:0048240)4.08027293
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.98826669
98negative regulation of meiosis (GO:0045835)3.98246130
99regulation of cardiac muscle contraction (GO:0055117)3.98028227
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.96426515
101outflow tract septum morphogenesis (GO:0003148)3.95167978
102creatine metabolic process (GO:0006600)3.94726011
103regulation of heart contraction (GO:0008016)3.93954120
104detection of external biotic stimulus (GO:0098581)3.93207386
105NADH metabolic process (GO:0006734)3.91730150
106energy homeostasis (GO:0097009)3.89678483
107chromosome organization involved in meiosis (GO:0070192)3.88589686
108male meiosis I (GO:0007141)3.87863913
109regulation of activation of Janus kinase activity (GO:0010533)3.87594722
110response to muscle activity (GO:0014850)3.86693318
111centriole assembly (GO:0098534)3.86004840
112cardiac muscle cell action potential (GO:0086001)3.83668630
113carnitine shuttle (GO:0006853)3.81137192
114* spermatogenesis (GO:0007283)3.76816167
115* male gamete generation (GO:0048232)3.76298743
116striated muscle adaptation (GO:0014888)3.74215777
117negative regulation of striated muscle cell apoptotic process (GO:0010664)3.67356258
118fertilization (GO:0009566)3.66728409
119tricarboxylic acid cycle (GO:0006099)3.66106878
120meiotic cell cycle (GO:0051321)3.65234100
121trivalent inorganic anion homeostasis (GO:0072506)3.64329107
122phosphate ion homeostasis (GO:0055062)3.64329107
123muscle fiber development (GO:0048747)3.63994394
124regulation of calcium ion transmembrane transporter activity (GO:1901019)3.63027479
125regulation of calcium ion transmembrane transport (GO:1903169)3.63027479
126cellular anion homeostasis (GO:0030002)3.62664252
127negative regulation of macroautophagy (GO:0016242)3.62479722
128interferon-gamma production (GO:0032609)3.62451226
129cardiac right ventricle morphogenesis (GO:0003215)3.60213205
130response to caffeine (GO:0031000)3.60135254
131regulation of muscle contraction (GO:0006937)3.59576086
132meiotic nuclear division (GO:0007126)3.58766133
133cardiac muscle cell action potential involved in contraction (GO:0086002)3.57985449
134relaxation of muscle (GO:0090075)3.55694577
135regulation of membrane repolarization (GO:0060306)3.55685537
136adrenergic receptor signaling pathway (GO:0071875)3.55469649
137positive regulation of cation channel activity (GO:2001259)3.54458891
138muscle cell development (GO:0055001)3.49155180
139regulation of sarcomere organization (GO:0060297)3.48627465
140* gamete generation (GO:0007276)3.45085051
141regulation of muscle system process (GO:0090257)3.44306011
142cardiac conduction (GO:0061337)3.41555039
143detection of biotic stimulus (GO:0009595)3.40825932
144cardiac muscle tissue development (GO:0048738)3.39995647
145ventricular cardiac muscle cell development (GO:0055015)3.35538819
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.32733904
147positive regulation of protein sumoylation (GO:0033235)3.29253644
148positive regulation of cardiac muscle tissue growth (GO:0055023)3.28458544
149endocardial cushion morphogenesis (GO:0003203)3.24586445
150positive regulation of heart rate (GO:0010460)3.24061956
151inner ear receptor stereocilium organization (GO:0060122)3.23895619
152negative regulation of myotube differentiation (GO:0010832)3.23891001
153regulation of myoblast differentiation (GO:0045661)3.23610237
154positive regulation of cardiac muscle cell proliferation (GO:0060045)3.22398545
155fatty acid transmembrane transport (GO:1902001)3.22112466
156pattern specification involved in kidney development (GO:0061004)3.21898303
157response to epinephrine (GO:0071871)3.21750719
158venous blood vessel morphogenesis (GO:0048845)3.19604941
159* germ cell development (GO:0007281)3.18375747
160regulation of spindle checkpoint (GO:0090231)3.18356314
161regulation of mitotic spindle checkpoint (GO:1903504)3.12004022
162regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12004022
163* cellular process involved in reproduction in multicellular organism (GO:0022412)3.05910900
164negative regulation of mast cell activation (GO:0033004)3.04389997
165meiosis I (GO:0007127)2.99548640
166replicative senescence (GO:0090399)2.98292700
167lateral ventricle development (GO:0021670)2.92137461
168regulation of DNA endoreduplication (GO:0032875)2.85953676
169ventricular system development (GO:0021591)2.85542261
170calcium ion-dependent exocytosis (GO:0017156)2.85055485
171negative regulation of skeletal muscle tissue development (GO:0048642)2.84787260
172seminiferous tubule development (GO:0072520)2.84646176
173regulation of centriole replication (GO:0046599)2.84641089
174pore complex assembly (GO:0046931)2.80995436
175organic cation transport (GO:0015695)2.80129258
176monoubiquitinated protein deubiquitination (GO:0035520)2.78055487
177meiotic cell cycle process (GO:1903046)2.77566250
178synapsis (GO:0007129)2.74662058
179histone H3-K9 modification (GO:0061647)2.73768570
180positive regulation of CREB transcription factor activity (GO:0032793)2.72340281
181microtubule polymerization or depolymerization (GO:0031109)2.71078057
182meiotic chromosome segregation (GO:0045132)2.69095920
183post-embryonic morphogenesis (GO:0009886)2.68283609
184reciprocal DNA recombination (GO:0035825)2.65981017
185reciprocal meiotic recombination (GO:0007131)2.65981017
186cilium assembly (GO:0042384)2.63970208
187* multicellular organismal reproductive process (GO:0048609)2.63489516
188cell recognition (GO:0008037)2.62653322
189cilium organization (GO:0044782)2.61726794
190cellular response to gamma radiation (GO:0071480)2.60955477
191female gonad development (GO:0008585)2.55799221
192multicellular organismal development (GO:0007275)2.55514385
193protein localization to cilium (GO:0061512)2.54302646
194left/right pattern formation (GO:0060972)2.53604103
195nuclear pore organization (GO:0006999)2.53463741
196gene silencing by RNA (GO:0031047)2.47471284
197daunorubicin metabolic process (GO:0044597)11.6204627
198polyketide metabolic process (GO:0030638)11.6204627
199doxorubicin metabolic process (GO:0044598)11.6204627
200cilium or flagellum-dependent cell motility (GO:0001539)10.1970361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.18294052
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.03056916
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.96965709
4EZH2_22144423_ChIP-Seq_EOC_Human4.89235658
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.41539737
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.19943839
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.40314633
8TBX20_22328084_ChIP-Seq_HEART_Mouse3.40314633
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.28557757
10CDX2_19796622_ChIP-Seq_MESCs_Mouse3.18617356
11PCGF2_27294783_Chip-Seq_ESCs_Mouse3.13734536
12FLI1_27457419_Chip-Seq_LIVER_Mouse3.03086473
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.56529093
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.56381430
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.55972828
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.53830649
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48145782
18PCGF2_27294783_Chip-Seq_NPCs_Mouse2.42817319
19GATA4_21415370_ChIP-Seq_HL-1_Mouse2.36637786
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20303488
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.11915852
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06099976
23STAT3_18555785_Chip-Seq_ESCs_Mouse2.02771027
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.01511637
25P53_22387025_ChIP-Seq_ESCs_Mouse2.00597034
26VDR_22108803_ChIP-Seq_LS180_Human1.99303761
27NANOG_18555785_Chip-Seq_ESCs_Mouse1.98714207
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.96477201
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.95148201
30SUZ12_18555785_Chip-Seq_ESCs_Mouse1.94264739
31GBX2_23144817_ChIP-Seq_PC3_Human1.91811561
32OCT4_18555785_Chip-Seq_ESCs_Mouse1.90688169
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.86579097
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.85286224
35NMYC_18555785_Chip-Seq_ESCs_Mouse1.84545664
36CMYC_18555785_Chip-Seq_ESCs_Mouse1.83666938
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.80199476
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79618086
39RNF2_27304074_Chip-Seq_NSC_Mouse1.79312502
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75623383
41KLF4_18555785_Chip-Seq_ESCs_Mouse1.75305773
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.74237641
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73055075
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72256530
45P300_18555785_Chip-Seq_ESCs_Mouse1.72049465
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.71050128
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.70991276
48ESRRB_18555785_Chip-Seq_ESCs_Mouse1.69249273
49ZFX_18555785_Chip-Seq_ESCs_Mouse1.68380690
50ISL1_27105846_Chip-Seq_CPCs_Mouse1.67680667
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65660766
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64636513
53NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.63702456
54PU1_27457419_Chip-Seq_LIVER_Mouse1.63205958
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.58199466
56CTCF_18555785_Chip-Seq_ESCs_Mouse1.56388289
57OCT4_21477851_ChIP-Seq_ESCs_Mouse1.52107103
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51317182
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51205301
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50540590
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.49575094
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49108325
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48978062
64IGF1R_20145208_ChIP-Seq_DFB_Human1.48613241
65ELK4_26923725_Chip-Seq_MESODERM_Mouse1.47957139
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47747642
67SMAD1_18555785_Chip-Seq_ESCs_Mouse1.47294531
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47058323
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.45826812
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45789178
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.41684785
72TAF15_26573619_Chip-Seq_HEK293_Human1.39526979
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38394302
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38214675
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.38214513
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.38146482
77STAT1_17558387_ChIP-Seq_HELA_Human1.37304407
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.35376707
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34849381
80KDM2B_26808549_Chip-Seq_REH_Human1.34701444
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33997952
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.33944610
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33759461
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33119448
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28751219
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27457714
87ER_23166858_ChIP-Seq_MCF-7_Human1.25254158
88TCF4_23295773_ChIP-Seq_U87_Human1.24725211
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24448456
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24297381
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23624300
92REST_21632747_ChIP-Seq_MESCs_Mouse1.22653389
93P300_19829295_ChIP-Seq_ESCs_Human1.21859802
94ZNF263_19887448_ChIP-Seq_K562_Human1.20647028
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20536933
96POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19781034
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.19370726
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19156182
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19156182
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.18242113
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17836018
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17084329
103SMAD4_21741376_ChIP-Seq_HESCs_Human1.16935238
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16607007
105CBP_20019798_ChIP-Seq_JUKART_Human1.15415277
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15415277
107BCAT_22108803_ChIP-Seq_LS180_Human1.13328737
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.12296653
109TBL1_22424771_ChIP-Seq_293T_Human1.12070115
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09642191
111* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09216132
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.09119817
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08751742
114GF1B_26923725_Chip-Seq_HPCs_Mouse1.07023100
115SMAD4_21799915_ChIP-Seq_A2780_Human1.06630083
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05827623
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05330649
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05180804
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.04625947
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04582576
121JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02872274
122STAT3_23295773_ChIP-Seq_U87_Human1.02858312
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02144313
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01400361
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01077125
126SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00775737
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.00662448
128SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99971340
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99255812
130WDR5_24793694_ChIP-Seq_LNCAP_Human0.98880762
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.98334326
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.98214878
133MYC_19829295_ChIP-Seq_ESCs_Human0.98060255
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.97690838
135GF1_26923725_Chip-Seq_HPCs_Mouse0.97587584
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97533033
137MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95633590
138NFYB_21822215_ChIP-Seq_K562_Human0.95578665
139JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95337663
140EWS_26573619_Chip-Seq_HEK293_Human0.94905055
141LXR_22158963_ChIP-Seq_LIVER_Mouse0.94724976
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94541370
143EZH2_27294783_Chip-Seq_ESCs_Mouse0.94155533
144EED_16625203_ChIP-ChIP_MESCs_Mouse0.94089265
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93986912
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93960041
147FUS_26573619_Chip-Seq_HEK293_Human0.93118271
148RUNX2_22187159_ChIP-Seq_PCA_Human0.92088899
149TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91759231
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90931344
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90931344
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90677133
153SOX2_19829295_ChIP-Seq_ESCs_Human0.90363777
154NANOG_19829295_ChIP-Seq_ESCs_Human0.90363777
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89898993
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89191230
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89191230
158CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88159252
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87401921
160MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87154863
161CLOCK_20551151_ChIP-Seq_293T_Human0.87101781
162SOX9_26525672_Chip-Seq_HEART_Mouse0.84599021
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83660189
164SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83120284
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82359985
166CTCF_27219007_Chip-Seq_Bcells_Human0.82325423
167PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81993030
168PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81653353
169GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81032350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.24023734
2MP0004084_abnormal_cardiac_muscle5.92738067
3MP0000751_myopathy5.69325302
4MP0002837_dystrophic_cardiac_calcinosis5.25316687
5MP0004036_abnormal_muscle_relaxation4.87604552
6MP0005377_hearing/vestibular/ear_phenot4.72758097
7MP0003878_abnormal_ear_physiology4.72758097
8MP0004145_abnormal_muscle_electrophysio4.54088966
9MP0004215_abnormal_myocardial_fiber4.35501833
10MP0005330_cardiomyopathy4.15961762
11MP0000749_muscle_degeneration4.13559139
12MP0008004_abnormal_stomach_pH3.77756976
13MP0003698_abnormal_male_reproductive3.47168098
14MP0002972_abnormal_cardiac_muscle3.45589908
15MP0008877_abnormal_DNA_methylation3.38354044
16MP0004510_myositis3.31077047
17MP0004087_abnormal_muscle_fiber3.23634780
18MP0005620_abnormal_muscle_contractility3.10270972
19MP0001929_abnormal_gametogenesis3.10212264
20MP0000566_synostosis2.99785232
21MP0002106_abnormal_muscle_physiology2.94940453
22MP0005645_abnormal_hypothalamus_physiol2.84377282
23MP0006292_abnormal_olfactory_placode2.84125360
24MP0003137_abnormal_impulse_conducting2.77403440
25MP0008775_abnormal_heart_ventricle2.76174946
26MP0010630_abnormal_cardiac_muscle2.60439835
27MP0002210_abnormal_sex_determination2.58542458
28MP0004484_altered_response_of2.55017151
29MP0000747_muscle_weakness2.45328139
30MP0005385_cardiovascular_system_phenoty2.44731361
31MP0001544_abnormal_cardiovascular_syste2.44731361
32MP0005369_muscle_phenotype2.43250527
33MP0003646_muscle_fatigue2.42435284
34MP0000750_abnormal_muscle_regeneration2.39131961
35MP0002269_muscular_atrophy2.37642346
36MP0009697_abnormal_copulation2.36876929
37MP0008058_abnormal_DNA_repair2.34637902
38MP0000678_abnormal_parathyroid_gland2.29078645
39MP0006138_congestive_heart_failure2.24211471
40MP0004130_abnormal_muscle_cell2.19081732
41MP0003941_abnormal_skin_development2.17399240
42MP0000759_abnormal_skeletal_muscle2.16148035
43MP0005646_abnormal_pituitary_gland2.13814787
44MP0008057_abnormal_DNA_replication2.10432026
45MP0004085_abnormal_heartbeat1.94542537
46MP0001986_abnormal_taste_sensitivity1.88148936
47MP0001145_abnormal_male_reproductive1.86639975
48MP0010094_abnormal_chromosome_stability1.82982469
49MP0001188_hyperpigmentation1.76231705
50MP0002161_abnormal_fertility/fecundity1.75810552
51MP0000653_abnormal_sex_gland1.74983161
52MP0002277_abnormal_respiratory_mucosa1.73679205
53MP0002332_abnormal_exercise_endurance1.71089507
54MP0002160_abnormal_reproductive_system1.66797610
55MP0002163_abnormal_gland_morphology1.65922654
56MP0003879_abnormal_hair_cell1.62574687
57MP0002132_abnormal_respiratory_system1.61252037
58MP0003011_delayed_dark_adaptation1.59225809
59MP0005647_abnormal_sex_gland1.58854220
60MP0005171_absent_coat_pigmentation1.56309427
61MP0003221_abnormal_cardiomyocyte_apopto1.50713570
62MP0003567_abnormal_fetal_cardiomyocyte1.50193817
63MP0003787_abnormal_imprinting1.45387311
64MP0004233_abnormal_muscle_weight1.44838955
65MP0005451_abnormal_body_composition1.40996781
66MP0003111_abnormal_nucleus_morphology1.39271454
67MP0001293_anophthalmia1.33371533
68MP0005389_reproductive_system_phenotype1.32633847
69MP0000733_abnormal_muscle_development1.29830785
70MP0002108_abnormal_muscle_morphology1.21886196
71MP0002735_abnormal_chemical_nociception1.20216986
72MP0004782_abnormal_surfactant_physiolog1.19273636
73MP0002938_white_spotting1.18460319
74MP0004133_heterotaxia1.17072487
75MP0006036_abnormal_mitochondrial_physio1.16705536
76MP0003950_abnormal_plasma_membrane1.16151025
77MP0001119_abnormal_female_reproductive1.14559420
78MP0005623_abnormal_meninges_morphology1.14427128
79MP0008995_early_reproductive_senescence1.12721724
80MP0001661_extended_life_span1.12445573
81MP0003786_premature_aging1.11025441
82MP0003828_pulmonary_edema1.09646923
83MP0000266_abnormal_heart_morphology1.09387701
84MP0001984_abnormal_olfaction1.07253675
85MP0000681_abnormal_thyroid_gland1.06228357
86MP0001485_abnormal_pinna_reflex1.06130816
87MP0009046_muscle_twitch1.05576670
88MP0004019_abnormal_vitamin_homeostasis1.05102505
89MP0004742_abnormal_vestibular_system1.02508732
90MP0005165_increased_susceptibility_to1.02106921
91MP0001486_abnormal_startle_reflex1.01615624
92MP0008007_abnormal_cellular_replicative1.00351615
93MP0000013_abnormal_adipose_tissue0.98355928
94MP0001919_abnormal_reproductive_system0.98020566
95MP0000490_abnormal_crypts_of0.94533537
96MP0005248_abnormal_Harderian_gland0.93300625
97MP0005670_abnormal_white_adipose0.92703385
98MP0002234_abnormal_pharynx_morphology0.90863506
99MP0005503_abnormal_tendon_morphology0.90830020
100MP0002102_abnormal_ear_morphology0.90545172
101MP0001764_abnormal_homeostasis0.87997111
102MP0001177_atelectasis0.87087556
103MP0003077_abnormal_cell_cycle0.86930404
104MP0001346_abnormal_lacrimal_gland0.84522663
105MP0005266_abnormal_metabolism0.83087467
106MP0002128_abnormal_blood_circulation0.80425381
107MP0010368_abnormal_lymphatic_system0.79703846
108MP0005666_abnormal_adipose_tissue0.78842908
109MP0004142_abnormal_muscle_tone0.78812190
110MP0009384_cardiac_valve_regurgitation0.76594605
111MP0005423_abnormal_somatic_nervous0.76183905
112MP0002148_abnormal_hypersensitivity_rea0.75725390
113MP0001873_stomach_inflammation0.72490974
114MP0002249_abnormal_larynx_morphology0.72133287
115MP0003279_aneurysm0.69535100
116MP0000026_abnormal_inner_ear0.69446191
117MP0000470_abnormal_stomach_morphology0.69064987
118MP0003763_abnormal_thymus_physiology0.67802407
119MP0002876_abnormal_thyroid_physiology0.67199461
120MP0002928_abnormal_bile_duct0.67059539
121MP0001324_abnormal_eye_pigmentation0.66211804
122MP0006276_abnormal_autonomic_nervous0.63659710
123MP0005375_adipose_tissue_phenotype0.61131618
124MP0004272_abnormal_basement_membrane0.60126145
125MP0003385_abnormal_body_wall0.59759475
126MP0002127_abnormal_cardiovascular_syste0.59747403
127MP0002971_abnormal_brown_adipose0.59239220
128MP0002396_abnormal_hematopoietic_system0.58343358
129MP0003136_yellow_coat_color0.57334915
130MP0003699_abnormal_female_reproductive0.57079464
131MP0003045_fibrosis0.57072022
132MP0003693_abnormal_embryo_hatching0.56538763
133MP0003936_abnormal_reproductive_system0.55590357
134MP0005257_abnormal_intraocular_pressure0.54785632
135MP0001963_abnormal_hearing_physiology0.54752560
136MP0002653_abnormal_ependyma_morphology0.52397638
137MP0001299_abnormal_eye_distance/0.51075923
138MP0005187_abnormal_penis_morphology0.49815023
139MP0000003_abnormal_adipose_tissue0.49369239
140MP0001502_abnormal_circadian_rhythm0.48542205
141MP0009785_altered_susceptibility_to0.47915836
142MP0003984_embryonic_growth_retardation0.47400356
143MP0000516_abnormal_urinary_system0.46176481
144MP0005367_renal/urinary_system_phenotyp0.46176481
145MP0002088_abnormal_embryonic_growth/wei0.46022954
146MP0002233_abnormal_nose_morphology0.45911346
147MP0005387_immune_system_phenotype0.45153035
148MP0001790_abnormal_immune_system0.45153035
149MP0002638_abnormal_pupillary_reflex0.45040895
150MP0001835_abnormal_antigen_presentation0.44934206
151MP0002184_abnormal_innervation0.44914267
152MP0002572_abnormal_emotion/affect_behav0.44638050
153MP0006082_CNS_inflammation0.42386918
154MP0002282_abnormal_trachea_morphology0.41950335
155MP0000579_abnormal_nail_morphology0.41940826
156MP0002075_abnormal_coat/hair_pigmentati0.41906734
157MP0001784_abnormal_fluid_regulation0.41864790
158MP0004808_abnormal_hematopoietic_stem0.41630725
159MP0002925_abnormal_cardiovascular_devel0.41381591
160MP0004185_abnormal_adipocyte_glucose0.38040526
161MP0002822_catalepsy0.38026339
162MP0010030_abnormal_orbit_morphology0.37810781
163MP0004270_analgesia0.36378455
164MP0008569_lethality_at_weaning0.36063173
165MP0006035_abnormal_mitochondrial_morpho0.35940277
166MP0000767_abnormal_smooth_muscle0.35583034
167MP0000230_abnormal_systemic_arterial0.34658349
168MP0009250_abnormal_appendicular_skeleto0.34448683
169MP0009672_abnormal_birth_weight0.32483185
170MP0000762_abnormal_tongue_morphology0.31842688
171MP0000462_abnormal_digestive_system0.31508499
172MP0005386_behavior/neurological_phenoty0.30731906
173MP0004924_abnormal_behavior0.30731906
174MP0000372_irregular_coat_pigmentation0.30494130
175MP0000343_altered_response_to0.30425013
176MP0001614_abnormal_blood_vessel0.29013605
177MP0001879_abnormal_lymphatic_vessel0.26874528
178MP0002078_abnormal_glucose_homeostasis0.25974602
179MP0003948_abnormal_gas_homeostasis0.23427165
180MP0001672_abnormal_embryogenesis/_devel0.23330837
181MP0005380_embryogenesis_phenotype0.23330837
182MP0003937_abnormal_limbs/digits/tail_de0.19371960
183MP0009780_abnormal_chondrocyte_physiolo0.18206795
184MP0001730_embryonic_growth_arrest0.17724588
185MP0001529_abnormal_vocalization0.17500391
186MP0005584_abnormal_enzyme/coenzyme_acti0.17287245

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.72620287
2Absent/shortened dynein arms (HP:0200106)9.72620287
3Sudden death (HP:0001699)7.73225311
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.48262499
5Muscle fiber inclusion bodies (HP:0100299)7.42639756
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.41105383
7Nemaline bodies (HP:0003798)7.27989870
8Bundle branch block (HP:0011710)6.96438415
9Ventricular tachycardia (HP:0004756)6.83966788
10Abnormal respiratory epithelium morphology (HP:0012253)6.69550990
11Abnormal respiratory motile cilium morphology (HP:0005938)6.69550990
12Type 1 muscle fiber predominance (HP:0003803)6.44866776
13Abnormal respiratory motile cilium physiology (HP:0012261)6.35181116
14Abnormality of the calf musculature (HP:0001430)6.12076610
15Hyporeflexia of lower limbs (HP:0002600)6.00465346
16Abnormal ciliary motility (HP:0012262)5.96582521
17Muscle hypertrophy of the lower extremities (HP:0008968)5.94714747
18Rhinitis (HP:0012384)5.92657455
19Calf muscle hypertrophy (HP:0008981)5.90265688
20Muscle fiber splitting (HP:0003555)5.70690276
21Exercise-induced muscle cramps (HP:0003710)5.66392629
22Subaortic stenosis (HP:0001682)5.59801039
23Abnormality of the left ventricular outflow tract (HP:0011103)5.59801039
24EMG: myopathic abnormalities (HP:0003458)5.42074355
25Exercise-induced myalgia (HP:0003738)5.29284350
26Atrial fibrillation (HP:0005110)5.22985915
27Lipoatrophy (HP:0100578)5.02003238
28Right ventricular cardiomyopathy (HP:0011663)4.72264613
29Primary atrial arrhythmia (HP:0001692)4.71760466
30Dilated cardiomyopathy (HP:0001644)4.59176987
31Supraventricular tachycardia (HP:0004755)4.57203774
32Centrally nucleated skeletal muscle fibers (HP:0003687)4.51936681
33Asymmetric septal hypertrophy (HP:0001670)4.50565557
34Supraventricular arrhythmia (HP:0005115)4.46103194
35Syncope (HP:0001279)4.45269756
36Heart block (HP:0012722)4.37029703
37Rimmed vacuoles (HP:0003805)4.33462705
38Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27502742
39Ventricular arrhythmia (HP:0004308)4.21363719
40Neck muscle weakness (HP:0000467)4.09707208
41Abnormal atrioventricular conduction (HP:0005150)4.08999651
42Myoglobinuria (HP:0002913)3.88751444
43Unilateral renal agenesis (HP:0000122)3.87547420
44Distal lower limb muscle weakness (HP:0009053)3.77892440
45Chromsome breakage (HP:0040012)3.75078011
46Rhabdomyolysis (HP:0003201)3.69491346
47Alopecia of scalp (HP:0002293)3.54649305
48EMG: neuropathic changes (HP:0003445)3.54227840
49Palpitations (HP:0001962)3.41075293
50Nephronophthisis (HP:0000090)3.36927670
51Difficulty running (HP:0009046)3.36654310
52Infertility (HP:0000789)3.35101539
53Areflexia of lower limbs (HP:0002522)3.22862182
54Absent eyebrow (HP:0002223)3.20096633
55Renal dysplasia (HP:0000110)3.18137638
56Myopathic facies (HP:0002058)3.16988113
57Abnormality of skeletal muscle fiber size (HP:0012084)3.16878349
58Increased connective tissue (HP:0009025)3.10259273
59Distal arthrogryposis (HP:0005684)3.06649207
60Parakeratosis (HP:0001036)3.05881091
61Left ventricular hypertrophy (HP:0001712)2.98215375
62Tubulointerstitial nephritis (HP:0001970)2.95113884
63Increased variability in muscle fiber diameter (HP:0003557)2.94996254
64Atrioventricular block (HP:0001678)2.93869833
65Bilateral sensorineural hearing impairment (HP:0008619)2.91883130
66Retrobulbar optic neuritis (HP:0100654)2.91701977
67Optic neuritis (HP:0100653)2.91701977
68Generalized muscle weakness (HP:0003324)2.91314199
69Chronic bronchitis (HP:0004469)2.89143369
70Bronchiectasis (HP:0002110)2.86940435
71Ventricular fibrillation (HP:0001663)2.83252633
72Mildly elevated creatine phosphokinase (HP:0008180)2.82844040
73Abnormality of dental color (HP:0011073)2.82547808
74Ragged-red muscle fibers (HP:0003200)2.79911590
75Chronic hepatic failure (HP:0100626)2.79624249
76Hip contracture (HP:0003273)2.79292393
77Follicular hyperkeratosis (HP:0007502)2.79006736
78Abnormality of the renal medulla (HP:0100957)2.72089045
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71447340
80Ectopic kidney (HP:0000086)2.69577998
81Hyperphosphatemia (HP:0002905)2.69239152
82Optic nerve hypoplasia (HP:0000609)2.68155743
83Nasal polyposis (HP:0100582)2.66465688
84Decreased central vision (HP:0007663)2.64503474
85Frequent falls (HP:0002359)2.57705076
86Prolonged QT interval (HP:0001657)2.52156954
87Abnormality of the foot musculature (HP:0001436)2.51288288
88Abnormal EKG (HP:0003115)2.51009807
89Septo-optic dysplasia (HP:0100842)2.50204554
90Absent eyelashes (HP:0000561)2.46657924
91Cheilitis (HP:0100825)2.41897106
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.40570974
93Abnormal spermatogenesis (HP:0008669)2.40387084
94Round ear (HP:0100830)2.40343132
95Bile duct proliferation (HP:0001408)2.37689074
96Abnormal biliary tract physiology (HP:0012439)2.37689074
97Myotonia (HP:0002486)2.37659865
98Prostate neoplasm (HP:0100787)2.34341584
99Distal lower limb amyotrophy (HP:0008944)2.30193942
100Duplicated collecting system (HP:0000081)2.26271465
101Meckel diverticulum (HP:0002245)2.25819507
102Patent foramen ovale (HP:0001655)2.25463240
103Muscular dystrophy (HP:0003560)2.24474267
104Recurrent sinusitis (HP:0011108)2.24333100
105Palmoplantar keratoderma (HP:0000982)2.22222909
106Difficulty climbing stairs (HP:0003551)2.22105495
107Abnormality of the ileum (HP:0001549)2.21849171
108Orchitis (HP:0100796)2.21736058
109Postaxial foot polydactyly (HP:0001830)2.21381173
110Azoospermia (HP:0000027)2.20351527
111Muscle stiffness (HP:0003552)2.19020087
112Progressive muscle weakness (HP:0003323)2.18757526
113Abnormality of the preputium (HP:0100587)2.18663037
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16599373
115Molar tooth sign on MRI (HP:0002419)2.16329506
116Abnormality of midbrain morphology (HP:0002418)2.16329506
117Congenital hepatic fibrosis (HP:0002612)2.13349197
118Absent epiphyses (HP:0010577)2.13217960
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13217960
120Scapular winging (HP:0003691)2.09818345
121Congenital malformation of the right heart (HP:0011723)2.09733203
122Double outlet right ventricle (HP:0001719)2.09733203
123Ulnar deviation of the wrist (HP:0003049)2.09214802
124Hypoplastic left heart (HP:0004383)2.08195717
125Foot dorsiflexor weakness (HP:0009027)2.07361594
126Abnormality of the renal collecting system (HP:0004742)2.07320130
127Tetany (HP:0001281)2.01659981
128Abolished electroretinogram (ERG) (HP:0000550)2.00652237
129True hermaphroditism (HP:0010459)1.98278449
130Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97327839
131Limited hip movement (HP:0008800)1.96998893
132Myositis (HP:0100614)1.95806763
133Chronic sinusitis (HP:0011109)1.95511733
134Absent phalangeal crease (HP:0006109)1.93663552
135Medial flaring of the eyebrow (HP:0010747)1.93639488
136Chronic otitis media (HP:0000389)1.91905812
137Gowers sign (HP:0003391)1.91884751
138Abnormality of the nasal mucosa (HP:0000433)1.90904635
139Bulbar palsy (HP:0001283)1.89101187
140Occipital encephalocele (HP:0002085)1.88878262
141Abnormality of the renal cortex (HP:0011035)1.88824597
142Clubbing of toes (HP:0100760)1.87517664
143Ectropion (HP:0000656)1.86897922
144Keratitis (HP:0000491)1.86161343
145Aplasia cutis congenita (HP:0001057)1.86070952
146Abnormality of chromosome stability (HP:0003220)1.85821234
147Limb-girdle muscle atrophy (HP:0003797)1.84153662
148Erythroderma (HP:0001019)1.83734541
149Hypoplastic heart (HP:0001961)1.83671729
150Neonatal hypoglycemia (HP:0001998)1.83596678
151Abnormality of the shoulder girdle musculature (HP:0001435)1.82789668
152Pancreatic fibrosis (HP:0100732)1.82479023
153Proximal amyotrophy (HP:0007126)1.82254994
154Waddling gait (HP:0002515)1.79714712
155Supernumerary spleens (HP:0009799)1.78139931
156Abnormality of the carotid arteries (HP:0005344)1.77806848
157Sudden cardiac death (HP:0001645)1.77343866
158Impulsivity (HP:0100710)1.76808521
159Steppage gait (HP:0003376)1.76242642
160Easy fatigability (HP:0003388)1.75356920
161Dyschromatopsia (HP:0007641)1.74671125
162Alveolar cell carcinoma (HP:0006519)1.74559965
163Absent speech (HP:0001344)1.73950216
164Bronchitis (HP:0012387)1.72519111
165Calcaneovalgus deformity (HP:0001848)1.72493702
166Lower limb amyotrophy (HP:0007210)1.72420391
167Facial cleft (HP:0002006)1.71948759
168Type 2 muscle fiber atrophy (HP:0003554)1.71640756
169Tubulointerstitial abnormality (HP:0001969)1.67031086
170Preaxial hand polydactyly (HP:0001177)1.66562566
171Abnormality of the tricuspid valve (HP:0001702)1.65183991
172Median cleft lip (HP:0000161)1.64822966
173Postaxial hand polydactyly (HP:0001162)1.64688280
174Retinal dysplasia (HP:0007973)1.63669273
175Tubular atrophy (HP:0000092)1.63628686
176Astigmatism (HP:0000483)1.63368642
177Recurrent corneal erosions (HP:0000495)1.61557301
178Gonadotropin excess (HP:0000837)1.61496589
179Congestive heart failure (HP:0001635)1.60650972
180Abnormality of the prostate (HP:0008775)1.59668508
181Nephroblastoma (Wilms tumor) (HP:0002667)1.59104751
182Weak cry (HP:0001612)1.58792946
183Pancreatic cysts (HP:0001737)1.58636162
184Bell-shaped thorax (HP:0001591)1.58616199
185Oligohydramnios (HP:0001562)1.58566427
186White forelock (HP:0002211)1.58539547
187Exercise intolerance (HP:0003546)1.56384222
188Toxemia of pregnancy (HP:0100603)1.55210406
189Deformed tarsal bones (HP:0008119)1.53625690
190Abnormality of the ischium (HP:0003174)1.53119372
191Hypoplastic ischia (HP:0003175)1.53048675
192Abnormal finger flexion creases (HP:0006143)1.51186786
193Respiratory insufficiency due to muscle weakness (HP:0002747)1.49447755
194Periauricular skin pits (HP:0100277)1.48056166
195Preauricular pit (HP:0004467)1.48056166
196Increased intramyocellular lipid droplets (HP:0012240)1.47731745
197Skin pits (HP:0100276)1.42592924
198Childhood onset (HP:0011463)1.41083536
199Increased serum pyruvate (HP:0003542)1.40752545
200Increased muscle lipid content (HP:0009058)1.40250085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.57550709
2TTN5.84191922
3SIK35.36069090
4STK38L4.71489349
5PHKG13.81031947
6PHKG23.81031947
7MYLK3.66158543
8PDK43.53404507
9PDK33.53404507
10STK243.28153120
11DMPK3.23350265
12PKN23.02283531
13SIK22.55980839
14PDK22.23552209
15MARK32.15520951
16TESK12.07385569
17ZAK2.02271810
18TXK1.97538623
19TNIK1.96858395
20SIK11.92639084
21MAPK121.89846132
22PRPF4B1.88932341
23PRKD31.77046258
24EPHA21.70399366
25MAP3K71.65546007
26FLT31.64016049
27STK31.56333150
28MAPKAPK31.52325960
29PIK3CA1.50315881
30MAP3K141.44825875
31EIF2AK21.42871702
32YES11.42497906
33MKNK21.34443025
34TRPM71.34362094
35TTK1.31570280
36BMPR1B1.27461955
37CAMK2D1.23888957
38ADRBK21.23709960
39CDK81.18409186
40MAP2K71.17209835
41PAK31.17067996
42PLK41.11372574
43CCNB11.08959608
44ATR1.08541027
45CAMK41.05541801
46NEK11.04943553
47NEK91.03864088
48STK381.01407873
49NEK21.01063676
50BRAF0.98669862
51PRKAA20.95968914
52CHEK20.95916926
53LIMK10.95899110
54PRKD10.94718795
55SGK20.93849154
56AKT30.92143767
57PTK2B0.90429327
58MARK10.88653727
59MAP3K50.85992810
60CAMK2A0.85797522
61AKT20.83234586
62ROCK10.83232139
63MAPK130.82138689
64CDK120.80706000
65MAP2K30.79886725
66MKNK10.79459830
67SRPK10.76936132
68WNK10.76136529
69CAMK2G0.75751416
70MAP2K40.72524088
71CDK70.70690336
72ICK0.70510863
73MAPK70.67900207
74NME10.67737402
75TAOK20.65388144
76PIM10.64262809
77PINK10.64217234
78PKN10.64003699
79MAP3K60.63176657
80PNCK0.62200185
81CDK40.61150582
82OBSCN0.58312099
83EEF2K0.57629050
84PLK10.57128134
85NTRK30.57082602
86CAMK10.56680039
87PRKD20.56214475
88CHEK10.54832555
89LATS20.54246570
90PRKCE0.53513018
91BMPR20.53355768
92MAPK150.52445281
93MAP3K100.51834776
94CDK30.51216823
95TIE10.51049268
96LMTK20.50862357
97PRKG10.50773000
98ATM0.50289741
99CLK10.49202369
100NEK60.48177795
101MAPK40.47963912
102EIF2AK10.47199238
103SGK30.46820253
104CDC42BPA0.45662319
105EPHB10.44532493
106NLK0.44458352
107PASK0.44382793
108PIK3CG0.43597217
109BRSK10.43551999
110PAK40.43249642
111JAK30.42725254
112PRKACA0.41918534
113CAMK2B0.40931378
114MAP2K10.39226192
115TEC0.38651193
116RPS6KB10.38533532
117STK160.38326713
118VRK10.38082156
119ROCK20.37749979
120IKBKB0.37709897
121RIPK10.37589131
122MUSK0.37411521
123RPS6KL10.36154242
124RPS6KC10.36154242
125EPHA30.36137013
126MAPK110.35692742
127MAP2K60.35621593
128MAP3K120.34991821
129SGK2230.34715161
130SGK4940.34715161
131IRAK10.34305474
132PLK20.34263619
133RET0.33199906
134PRKACG0.33067577
135PLK30.33037661
136CDC70.32875099
137RPS6KA60.30389329
138CSNK2A10.30112027
139BRSK20.30022261
140GRK10.28629740
141PRKACB0.28624935
142PDK10.28594346
143MARK20.28310067
144STK110.28240407
145BCKDK0.28032305
146CSNK1D0.27909185
147CHUK0.27736859
148ERBB30.27616119
149CSNK1A1L0.27526793
150RPS6KA30.26548026
151WNK40.26475146
152PRKAA10.26122709
153RPS6KB20.25619652
154RPS6KA10.25602188
155KSR20.25595366
156LATS10.25521686
157GRK70.24924767
158FGFR10.24819273
159STK40.24690332
160TNK20.24486029
161INSRR0.23625341
162BCR0.22724973
163MAPK100.22647110
164TRIB30.20481605
165DYRK1B0.19889417
166DAPK30.16033325
167MET0.15416685
168PDPK10.14810924
169FRK0.12220652
170TGFBR20.10764456
171UHMK10.10326465
172PRKDC0.09065789
173MTOR0.08173434
174SGK10.07329266

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054145.39225891
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054105.29907991
3Cardiac muscle contraction_Homo sapiens_hsa042605.01547228
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.12179157
5Fanconi anemia pathway_Homo sapiens_hsa034603.84006182
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.75519775
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.70648857
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.70227713
9Basal transcription factors_Homo sapiens_hsa030223.02955153
10Homologous recombination_Homo sapiens_hsa034402.85782354
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.82444936
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.82332709
13Graft-versus-host disease_Homo sapiens_hsa053322.25109869
14DNA replication_Homo sapiens_hsa030302.12895315
15Vitamin B6 metabolism_Homo sapiens_hsa007502.06567588
16Autoimmune thyroid disease_Homo sapiens_hsa053201.91286446
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89278831
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.87872543
19Carbon metabolism_Homo sapiens_hsa012001.75940626
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.68891403
21Circadian rhythm_Homo sapiens_hsa047101.68663323
22Allograft rejection_Homo sapiens_hsa053301.65648888
23Pyruvate metabolism_Homo sapiens_hsa006201.65375989
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65205290
25Measles_Homo sapiens_hsa051621.62050360
26Base excision repair_Homo sapiens_hsa034101.61810886
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59270165
28Parkinsons disease_Homo sapiens_hsa050121.55851515
29Nicotine addiction_Homo sapiens_hsa050331.52507626
30Mismatch repair_Homo sapiens_hsa034301.50523750
31Arginine biosynthesis_Homo sapiens_hsa002201.45985123
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40240540
33Purine metabolism_Homo sapiens_hsa002301.39764144
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.37920042
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37893474
36Herpes simplex infection_Homo sapiens_hsa051681.37144641
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36674061
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36146051
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34801994
40Fatty acid degradation_Homo sapiens_hsa000711.34667324
41Type I diabetes mellitus_Homo sapiens_hsa049401.33316400
42Cell cycle_Homo sapiens_hsa041101.30787358
43One carbon pool by folate_Homo sapiens_hsa006701.30639720
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30090756
45Nucleotide excision repair_Homo sapiens_hsa034201.29960392
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.28598406
47Non-homologous end-joining_Homo sapiens_hsa034501.27616283
48Selenocompound metabolism_Homo sapiens_hsa004501.26097560
49Oxytocin signaling pathway_Homo sapiens_hsa049211.22526677
50Arginine and proline metabolism_Homo sapiens_hsa003301.21016529
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19767940
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18642609
53Pyrimidine metabolism_Homo sapiens_hsa002401.18222216
54Fatty acid biosynthesis_Homo sapiens_hsa000611.16169275
55Hematopoietic cell lineage_Homo sapiens_hsa046401.14809018
56Tight junction_Homo sapiens_hsa045301.13702863
57Taste transduction_Homo sapiens_hsa047421.13571185
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13235068
59Alzheimers disease_Homo sapiens_hsa050101.13172714
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.12507218
61Linoleic acid metabolism_Homo sapiens_hsa005911.12338244
62Insulin signaling pathway_Homo sapiens_hsa049101.11033508
63Oxidative phosphorylation_Homo sapiens_hsa001901.10654858
64Insulin resistance_Homo sapiens_hsa049311.07782986
65Renin secretion_Homo sapiens_hsa049241.07742033
66African trypanosomiasis_Homo sapiens_hsa051431.06271498
67PPAR signaling pathway_Homo sapiens_hsa033201.03766859
68Phenylalanine metabolism_Homo sapiens_hsa003601.02826662
69Arachidonic acid metabolism_Homo sapiens_hsa005901.02367527
70Mineral absorption_Homo sapiens_hsa049781.01550338
71Calcium signaling pathway_Homo sapiens_hsa040200.99514961
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95668996
73Insulin secretion_Homo sapiens_hsa049110.95225584
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94852348
75Influenza A_Homo sapiens_hsa051640.94564792
76Fatty acid metabolism_Homo sapiens_hsa012120.93773253
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93629958
78Chemical carcinogenesis_Homo sapiens_hsa052040.91722961
79Legionellosis_Homo sapiens_hsa051340.91700828
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90182771
81Morphine addiction_Homo sapiens_hsa050320.88163304
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87411042
83RNA transport_Homo sapiens_hsa030130.86760717
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86612860
85Biosynthesis of amino acids_Homo sapiens_hsa012300.84493341
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84072407
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83914004
88Primary immunodeficiency_Homo sapiens_hsa053400.83448591
89Notch signaling pathway_Homo sapiens_hsa043300.81458053
90Rheumatoid arthritis_Homo sapiens_hsa053230.80914161
91cAMP signaling pathway_Homo sapiens_hsa040240.80859249
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80080483
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.79186363
94Glucagon signaling pathway_Homo sapiens_hsa049220.79185184
95Viral myocarditis_Homo sapiens_hsa054160.79114432
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78134085
97AMPK signaling pathway_Homo sapiens_hsa041520.77642454
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77194915
99Wnt signaling pathway_Homo sapiens_hsa043100.77083200
100Focal adhesion_Homo sapiens_hsa045100.76129811
101RNA degradation_Homo sapiens_hsa030180.73768840
102Gastric acid secretion_Homo sapiens_hsa049710.73485352
103HTLV-I infection_Homo sapiens_hsa051660.73425922
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73406246
105Regulation of autophagy_Homo sapiens_hsa041400.73343753
106ABC transporters_Homo sapiens_hsa020100.72000559
107Propanoate metabolism_Homo sapiens_hsa006400.71904922
108Adherens junction_Homo sapiens_hsa045200.71290215
109p53 signaling pathway_Homo sapiens_hsa041150.71163334
110mRNA surveillance pathway_Homo sapiens_hsa030150.71005594
111Amphetamine addiction_Homo sapiens_hsa050310.68327991
112Circadian entrainment_Homo sapiens_hsa047130.67480261
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66164470
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.65785655
115Butanoate metabolism_Homo sapiens_hsa006500.65443360
116Starch and sucrose metabolism_Homo sapiens_hsa005000.64054206
117TNF signaling pathway_Homo sapiens_hsa046680.63268040
118Vitamin digestion and absorption_Homo sapiens_hsa049770.61261691
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60102927
120Inositol phosphate metabolism_Homo sapiens_hsa005620.59850266
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58850714
122Fatty acid elongation_Homo sapiens_hsa000620.58266599
123Pentose phosphate pathway_Homo sapiens_hsa000300.57264701
124Synaptic vesicle cycle_Homo sapiens_hsa047210.56523313
125Basal cell carcinoma_Homo sapiens_hsa052170.55243048
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54179966
127Tryptophan metabolism_Homo sapiens_hsa003800.52229059
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52022942
129Sphingolipid metabolism_Homo sapiens_hsa006000.51452950
130Pancreatic secretion_Homo sapiens_hsa049720.50855762
131Lysine degradation_Homo sapiens_hsa003100.50673369
132ECM-receptor interaction_Homo sapiens_hsa045120.50292871
133Sulfur relay system_Homo sapiens_hsa041220.49780247
134Olfactory transduction_Homo sapiens_hsa047400.48921544
135Ovarian steroidogenesis_Homo sapiens_hsa049130.47600160
136Retinol metabolism_Homo sapiens_hsa008300.47485027
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47464415
138Galactose metabolism_Homo sapiens_hsa000520.46869300
139Salmonella infection_Homo sapiens_hsa051320.46726639
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45586798
141Serotonergic synapse_Homo sapiens_hsa047260.45568484
142Huntingtons disease_Homo sapiens_hsa050160.45510442
143Leishmaniasis_Homo sapiens_hsa051400.43968069
144Tuberculosis_Homo sapiens_hsa051520.43824825
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43459666
146GnRH signaling pathway_Homo sapiens_hsa049120.43275735
147Hedgehog signaling pathway_Homo sapiens_hsa043400.42794783
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42733275
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42480268
150Axon guidance_Homo sapiens_hsa043600.42468993
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42219453
152Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42066605
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.41460925
154Fructose and mannose metabolism_Homo sapiens_hsa000510.41439024
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41386721
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40591915
157Dorso-ventral axis formation_Homo sapiens_hsa043200.38880996
158Peroxisome_Homo sapiens_hsa041460.36837488
159Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36708614
160Bile secretion_Homo sapiens_hsa049760.36179373
161beta-Alanine metabolism_Homo sapiens_hsa004100.35458129
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34656571
163Phagosome_Homo sapiens_hsa041450.34328530
164Steroid biosynthesis_Homo sapiens_hsa001000.33827189
165Malaria_Homo sapiens_hsa051440.33641817
166Cholinergic synapse_Homo sapiens_hsa047250.30968428
167Nitrogen metabolism_Homo sapiens_hsa009100.30014934
168Protein digestion and absorption_Homo sapiens_hsa049740.29668852
169Central carbon metabolism in cancer_Homo sapiens_hsa052300.28619097
170Amoebiasis_Homo sapiens_hsa051460.28331542
171Salivary secretion_Homo sapiens_hsa049700.28068434
172Tyrosine metabolism_Homo sapiens_hsa003500.27109932
173Gap junction_Homo sapiens_hsa045400.26703504
174Hippo signaling pathway_Homo sapiens_hsa043900.26363589
175Melanogenesis_Homo sapiens_hsa049160.26224668
176Leukocyte transendothelial migration_Homo sapiens_hsa046700.25281580
177Long-term potentiation_Homo sapiens_hsa047200.22491001
178GABAergic synapse_Homo sapiens_hsa047270.21316734
179Thyroid hormone synthesis_Homo sapiens_hsa049180.20062877
180Endometrial cancer_Homo sapiens_hsa052130.16733022
181MAPK signaling pathway_Homo sapiens_hsa040100.16555658
182FoxO signaling pathway_Homo sapiens_hsa040680.13796809
183Glycerophospholipid metabolism_Homo sapiens_hsa005640.13274196
184Platelet activation_Homo sapiens_hsa046110.11086093
185TGF-beta signaling pathway_Homo sapiens_hsa043500.10475537
186Type II diabetes mellitus_Homo sapiens_hsa049300.09574214

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