PRSS45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.94164945
2multicellular organism reproduction (GO:0032504)9.60171109
3cell wall macromolecule metabolic process (GO:0044036)9.54258230
4cell wall macromolecule catabolic process (GO:0016998)9.54258230
5cell-cell recognition (GO:0009988)9.44064840
6spermatid development (GO:0007286)9.34966435
7motile cilium assembly (GO:0044458)9.30081899
8epithelial cilium movement (GO:0003351)9.27966142
9plasma membrane fusion (GO:0045026)8.96035819
10actin-mediated cell contraction (GO:0070252)8.84144613
11male meiosis (GO:0007140)8.56653154
12sarcoplasmic reticulum calcium ion transport (GO:0070296)8.47376814
13sarcomere organization (GO:0045214)8.40140139
14myofibril assembly (GO:0030239)8.39666911
15synaptonemal complex organization (GO:0070193)8.35607236
16synaptonemal complex assembly (GO:0007130)8.12811613
17reproduction (GO:0000003)8.08148778
18cardiac myofibril assembly (GO:0055003)7.98271895
19cilium movement (GO:0003341)7.95387064
20regulation of cilium movement (GO:0003352)7.86261706
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.66758018
22regulation of relaxation of muscle (GO:1901077)7.35750799
23cardiac muscle contraction (GO:0060048)7.08525635
24striated muscle contraction (GO:0006941)7.07667809
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.88274013
26regulation of actin filament-based movement (GO:1903115)6.74946011
27skeletal muscle contraction (GO:0003009)6.71392525
28single fertilization (GO:0007338)6.66752864
29negative regulation of inclusion body assembly (GO:0090084)6.65019640
30regulation of skeletal muscle contraction (GO:0014819)6.59812226
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.58091809
32DNA methylation involved in gamete generation (GO:0043046)6.56993168
33actin filament-based movement (GO:0030048)6.56696260
34sperm capacitation (GO:0048240)6.54750364
35spermatogenesis (GO:0007283)6.46651953
36male gamete generation (GO:0048232)6.44457414
37male meiosis I (GO:0007141)6.29683855
38cardiac muscle cell development (GO:0055013)6.18941702
39actomyosin structure organization (GO:0031032)5.99819000
40fertilization (GO:0009566)5.98346496
41microtubule depolymerization (GO:0007019)5.95759200
42gamete generation (GO:0007276)5.93444679
43cardiac muscle hypertrophy (GO:0003300)5.93069076
44adult heart development (GO:0007512)5.78786879
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.75522605
46cardiac cell development (GO:0055006)5.73578871
47chromosome organization involved in meiosis (GO:0070192)5.69524306
48striated muscle hypertrophy (GO:0014897)5.68925411
49cardiac muscle tissue morphogenesis (GO:0055008)5.68696603
50regulation of the force of heart contraction (GO:0002026)5.64769057
51organic cation transport (GO:0015695)5.54211586
52creatine metabolic process (GO:0006600)5.51265185
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.42767503
54germ cell development (GO:0007281)5.39687157
55regulation of inclusion body assembly (GO:0090083)5.38367175
56muscle tissue morphogenesis (GO:0060415)5.35034896
57meiotic nuclear division (GO:0007126)5.34388505
58cellular process involved in reproduction in multicellular organism (GO:0022412)5.30386270
59meiosis I (GO:0007127)5.23008730
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.19078143
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.16745015
62ventricular system development (GO:0021591)5.05097202
63muscle hypertrophy (GO:0014896)5.00212937
64calcium ion-dependent exocytosis (GO:0017156)4.94378590
65muscle contraction (GO:0006936)4.93542750
66seminiferous tubule development (GO:0072520)4.92093345
67microtubule severing (GO:0051013)4.88590240
68response to muscle activity (GO:0014850)4.88544717
69ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.87386791
70meiotic cell cycle (GO:0051321)4.84709989
71chromosome condensation (GO:0030261)4.73996018
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.68689696
73multicellular organismal reproductive process (GO:0048609)4.64935879
74response to inactivity (GO:0014854)4.64479768
75NADH metabolic process (GO:0006734)4.64176285
76DNA packaging (GO:0006323)4.61876829
77regulation of cell communication by electrical coupling (GO:0010649)4.61598979
78cardiac chamber formation (GO:0003207)4.60321723
79regulation of striated muscle contraction (GO:0006942)4.58897793
80regulation of microtubule-based movement (GO:0060632)4.58001088
81cell recognition (GO:0008037)4.49395287
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.48367252
83muscle system process (GO:0003012)4.46040369
84negative regulation of potassium ion transmembrane transport (GO:1901380)4.39602243
85regulation of cardioblast differentiation (GO:0051890)4.37323070
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.35423079
87striated muscle cell development (GO:0055002)4.34627722
88regulation of ATPase activity (GO:0043462)4.25450549
89regulation of ATP catabolic process (GO:1903289)4.25450549
90muscle fiber development (GO:0048747)4.20401343
91negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.18849485
92cardiac muscle hypertrophy in response to stress (GO:0014898)4.18002068
93muscle hypertrophy in response to stress (GO:0003299)4.18002068
94cardiac muscle adaptation (GO:0014887)4.18002068
95positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.17034702
96ventricular cardiac muscle cell action potential (GO:0086005)4.14199505
97spermatid nucleus differentiation (GO:0007289)4.12054652
98relaxation of cardiac muscle (GO:0055119)4.10121163
99left/right pattern formation (GO:0060972)4.07138997
100tricarboxylic acid cycle (GO:0006099)4.06821504
1012-oxoglutarate metabolic process (GO:0006103)4.04496984
102striated muscle adaptation (GO:0014888)4.02789534
103skeletal muscle adaptation (GO:0043501)3.92156604
104protein localization to cilium (GO:0061512)3.91341698
105skeletal muscle fiber development (GO:0048741)3.88048380
106regulation of heart rate (GO:0002027)3.87454826
107cell communication involved in cardiac conduction (GO:0086065)3.83790057
108cell communication by electrical coupling (GO:0010644)3.83010242
109glycerol ether metabolic process (GO:0006662)3.81931744
110chaperone-mediated protein complex assembly (GO:0051131)3.80683367
111regulation of membrane repolarization (GO:0060306)3.79214979
112muscle cell development (GO:0055001)3.77959748
113carnitine shuttle (GO:0006853)3.75423092
114genitalia morphogenesis (GO:0035112)3.74292470
115multicellular organismal development (GO:0007275)3.70614956
116cardiac ventricle formation (GO:0003211)3.69807779
117regulation of cardiac muscle cell contraction (GO:0086004)3.69052236
118myotube cell development (GO:0014904)3.68425986
119gene silencing by RNA (GO:0031047)3.66410215
120heart contraction (GO:0060047)3.65299147
121heart process (GO:0003015)3.65299147
122bundle of His cell to Purkinje myocyte communication (GO:0086069)3.63487998
123meiotic cell cycle process (GO:1903046)3.63181461
124protein polyglutamylation (GO:0018095)3.62426901
125regulation of meiosis I (GO:0060631)3.61010331
126cardiac muscle cell action potential (GO:0086001)3.59350339
127glycogen catabolic process (GO:0005980)3.59083327
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55145982
129ether metabolic process (GO:0018904)3.51280325
130muscle cell fate commitment (GO:0042693)3.50457991
131regulation of heart contraction (GO:0008016)3.48685338
132otic vesicle formation (GO:0030916)3.47282453
133glucan biosynthetic process (GO:0009250)3.46455358
134glycogen biosynthetic process (GO:0005978)3.46455358
135monoubiquitinated protein deubiquitination (GO:0035520)3.45304462
136regulation of spindle checkpoint (GO:0090231)3.44922305
137plasma membrane repair (GO:0001778)3.44196054
138regulation of calcium ion transmembrane transporter activity (GO:1901019)3.43490085
139regulation of calcium ion transmembrane transport (GO:1903169)3.43490085
140negative regulation of organelle assembly (GO:1902116)3.43154167
141relaxation of muscle (GO:0090075)3.41462510
142cardiac muscle cell action potential involved in contraction (GO:0086002)3.41030406
143regulation of muscle contraction (GO:0006937)3.40275576
144positive regulation of cation channel activity (GO:2001259)3.35032257
145glucan catabolic process (GO:0009251)3.32626409
146axoneme assembly (GO:0035082)3.30135377
147single strand break repair (GO:0000012)3.29778711
148regulation of sarcomere organization (GO:0060297)3.27104233
149synapsis (GO:0007129)3.26144828
150skeletal muscle tissue development (GO:0007519)3.25876948
151regulation of muscle system process (GO:0090257)3.25705894
152oxaloacetate metabolic process (GO:0006107)3.25498832
153intraciliary transport (GO:0042073)3.20090655
154muscle adaptation (GO:0043500)3.18497548
155regulation of skeletal muscle cell differentiation (GO:2001014)3.18133150
156regulation of myoblast differentiation (GO:0045661)3.16275005
157negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.12169184
158negative regulation of calcium ion transmembrane transport (GO:1903170)3.12169184
159alditol metabolic process (GO:0019400)3.12153890
160cellular polysaccharide catabolic process (GO:0044247)3.11730391
161fatty acid transmembrane transport (GO:1902001)3.10569861
162microtubule polymerization or depolymerization (GO:0031109)3.09589227
163regulation of centriole replication (GO:0046599)3.06507410
164microtubule-based movement (GO:0007018)3.06499383
165carnitine transport (GO:0015879)3.06111051
166amino-acid betaine transport (GO:0015838)3.06111051
167nucleus organization (GO:0006997)3.05096706
168polyol catabolic process (GO:0046174)3.03067469
169carnitine transmembrane transport (GO:1902603)3.00754866
170protein refolding (GO:0042026)3.00344962
171mitotic sister chromatid cohesion (GO:0007064)2.97146396
172glycolytic process (GO:0006096)2.96334615
173interferon-gamma secretion (GO:0072643)2.95159016
174protein K11-linked deubiquitination (GO:0035871)2.87951782
175lactate metabolic process (GO:0006089)2.87151837
176cilium organization (GO:0044782)2.86943098
177cilium morphogenesis (GO:0060271)2.86039589
178gene silencing (GO:0016458)2.85164639
179nucleoside diphosphate phosphorylation (GO:0006165)2.83745969
180sexual reproduction (GO:0019953)2.76070621
181cilium assembly (GO:0042384)2.73049495
182sequestering of actin monomers (GO:0042989)2.71308750
183glycerol metabolic process (GO:0006071)2.71277606
184cellular component assembly involved in morphogenesis (GO:0010927)2.68062551
185regulation of histone H3-K9 methylation (GO:0051570)2.66762549
186histone exchange (GO:0043486)2.66748906
187nuclear pore complex assembly (GO:0051292)2.57882437
188protein localization to chromosome, centromeric region (GO:0071459)2.56323140
189sex differentiation (GO:0007548)2.55640366
190DNA alkylation (GO:0006305)2.54414592
191sperm motility (GO:0030317)12.4821647
192cilium or flagellum-dependent cell motility (GO:0001539)12.4337410
193fusion of sperm to egg plasma membrane (GO:0007342)11.8188890
194acrosome reaction (GO:0007340)11.2396928
195acrosome assembly (GO:0001675)10.8811379
196actin-myosin filament sliding (GO:0033275)10.7774793
197muscle filament sliding (GO:0030049)10.7774793
198sperm-egg recognition (GO:0035036)10.6074858
199piRNA metabolic process (GO:0034587)10.3896214
200axonemal dynein complex assembly (GO:0070286)10.2194828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.13755394
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.88829624
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.18283297
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91173046
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.55650344
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36192782
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.17536342
8TBX20_22328084_ChIP-Seq_HEART_Mouse3.17536342
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.07005586
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94007015
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.90302685
12MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.62398075
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.62349542
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.59726587
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49465357
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.39534935
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28622310
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23310308
19GATA4_21415370_ChIP-Seq_HL-1_Mouse2.21116197
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.17095142
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15358752
22VDR_22108803_ChIP-Seq_LS180_Human2.07555840
23ZNF274_21170338_ChIP-Seq_K562_Hela2.07156680
24ELK4_26923725_Chip-Seq_MESODERM_Mouse2.01178321
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.01072152
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.1003342
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93643540
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91978275
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79546162
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75904129
31NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.74320965
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73765331
33STAT1_17558387_ChIP-Seq_HELA_Human1.71222399
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65635499
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.65267463
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63727357
37IGF1R_20145208_ChIP-Seq_DFB_Human1.62971092
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.57467843
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56747706
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55184960
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.53330329
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.53004199
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51717658
44SMAD3_21741376_ChIP-Seq_HESCs_Human1.51587377
45GBX2_23144817_ChIP-Seq_PC3_Human1.50509642
46KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50459528
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.46464674
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.46268035
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45365008
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43983536
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.43174747
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40355131
53FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38811680
54CTCF_27219007_Chip-Seq_Bcells_Human1.37659850
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36514042
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35435777
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35101298
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34253175
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33916859
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32002288
61SMAD4_21741376_ChIP-Seq_HESCs_Human1.31825276
62LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30807967
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30591865
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30333644
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.28356487
66REST_21632747_ChIP-Seq_MESCs_Mouse1.25391094
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25026029
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25000768
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25000768
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23772656
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22700194
72KDM2B_26808549_Chip-Seq_REH_Human1.21739815
73CLOCK_20551151_ChIP-Seq_293T_Human1.21388414
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20768992
75P53_21459846_ChIP-Seq_SAOS-2_Human1.20260476
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.20018909
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18639865
78CBP_20019798_ChIP-Seq_JUKART_Human1.18639865
79SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.18264543
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.16601033
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16120578
82SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15217783
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13832421
84RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13615074
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.13084303
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12489874
87PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12378246
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12318702
89STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12068295
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.11959118
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11394155
92CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10931438
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10566154
94* GATA3_21867929_ChIP-Seq_TH1_Mouse1.09395737
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.08913172
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08848199
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07002318
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.06344627
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03437656
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03391871
101MYC_27129775_Chip-Seq_CORNEA_Mouse1.01581570
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.01253491
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00904892
104SPI1_26923725_Chip-Seq_HPCs_Mouse1.00831714
105GF1_26923725_Chip-Seq_HPCs_Mouse1.00643350
106ZNF263_19887448_ChIP-Seq_K562_Human0.99678382
107RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99675095
108RNF2_27304074_Chip-Seq_NSC_Mouse0.98280311
109RARB_27405468_Chip-Seq_BRAIN_Mouse0.97822813
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97652256
111NANOG_18555785_Chip-Seq_ESCs_Mouse0.97085063
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96175368
113OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95729479
114* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94864961
115ERG_20517297_ChIP-Seq_VCAP_Human0.94217637
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93099248
117OCT4_18555785_Chip-Seq_ESCs_Mouse0.93098938
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92694365
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92394033
120RXR_22158963_ChIP-Seq_LIVER_Mouse0.92377430
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.92290068
122NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92190928
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.92084743
124SMAD4_21799915_ChIP-Seq_A2780_Human0.91963732
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91457914
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90612527
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.90345528
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90279780
129CBX2_27304074_Chip-Seq_ESCs_Mouse0.90145210
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.89986158
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89795701
132JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88622168
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88616588
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88264425
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87861139
136ESET_19884257_ChIP-Seq_ESCs_Mouse0.87796390
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87231113
138P53_22387025_ChIP-Seq_ESCs_Mouse0.87202056
139LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87097536
140EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86275958
141HTT_18923047_ChIP-ChIP_STHdh_Human0.86268793
142OCT4_20526341_ChIP-Seq_ESCs_Human0.86180929
143SOX2_21211035_ChIP-Seq_LN229_Human0.86172670
144LXR_22158963_ChIP-Seq_LIVER_Mouse0.86032751
145STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86021295
146PHF8_20622853_ChIP-Seq_HELA_Human0.85857672
147* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85591502
148FLI1_21867929_ChIP-Seq_CD8_Mouse0.84889232
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84655561
150NFYB_21822215_ChIP-Seq_K562_Human0.84611681
151P300_18555785_Chip-Seq_ESCs_Mouse0.84512025
152DROSHA_22980978_ChIP-Seq_HELA_Human0.84282265
153ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83775478
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83647029
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83528914
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.83196163
157CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83087849
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82647823
159TBL1_22424771_ChIP-Seq_293T_Human0.82308819
160CTCF_20526341_ChIP-Seq_ESCs_Human0.82131055
161RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81343786
162* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81241048
163CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80689280
164ESR2_21235772_ChIP-Seq_MCF-7_Human0.80516510
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80010909
166SOX2_21211035_ChIP-Seq_LN229_Gbm0.79894382
167WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79218779
168AR_21572438_ChIP-Seq_LNCaP_Human0.77135499
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75822068
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74480853
171SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74434550
172SOX9_26525672_Chip-Seq_HEART_Mouse0.74334040
173SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73835987
174TCF4_23295773_ChIP-Seq_U87_Human0.73510238
175SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73078589
176PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.72306688
177SOX2_19829295_ChIP-Seq_ESCs_Human0.71799269
178NANOG_19829295_ChIP-Seq_ESCs_Human0.71799269
179EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71458915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.91455497
2MP0000751_myopathy5.84987326
3MP0001929_abnormal_gametogenesis5.57742174
4MP0004145_abnormal_muscle_electrophysio5.31472569
5MP0004084_abnormal_cardiac_muscle5.13303772
6MP0008877_abnormal_DNA_methylation4.90708390
7MP0002837_dystrophic_cardiac_calcinosis4.85654130
8MP0000749_muscle_degeneration4.54149831
9MP0002210_abnormal_sex_determination3.79350356
10MP0005330_cardiomyopathy3.60837125
11MP0004215_abnormal_myocardial_fiber3.42948705
12MP0004087_abnormal_muscle_fiber3.32249537
13MP0002106_abnormal_muscle_physiology3.27815124
14MP0002161_abnormal_fertility/fecundity3.26007194
15MP0001145_abnormal_male_reproductive3.18007970
16MP0005620_abnormal_muscle_contractility3.07098941
17MP0002972_abnormal_cardiac_muscle3.05556773
18MP0002653_abnormal_ependyma_morphology3.02004263
19MP0000653_abnormal_sex_gland2.81928918
20MP0005369_muscle_phenotype2.75433908
21MP0000747_muscle_weakness2.62637922
22MP0000750_abnormal_muscle_regeneration2.57774464
23MP0000759_abnormal_skeletal_muscle2.57413507
24MP0010630_abnormal_cardiac_muscle2.37942698
25MP0005670_abnormal_white_adipose2.29243468
26MP0003137_abnormal_impulse_conducting2.20216501
27MP0003646_muscle_fatigue2.19729746
28MP0008775_abnormal_heart_ventricle2.14270256
29MP0002332_abnormal_exercise_endurance2.13264258
30MP0004130_abnormal_muscle_cell2.12132635
31MP0001544_abnormal_cardiovascular_syste2.08349621
32MP0005385_cardiovascular_system_phenoty2.08349621
33MP0004510_myositis2.01915363
34MP0005410_abnormal_fertilization15.1098165
35MP0004484_altered_response_of1.94587844
36MP0006138_congestive_heart_failure1.91653326
37MP0002160_abnormal_reproductive_system1.89815506
38MP0002127_abnormal_cardiovascular_syste1.86819431
39MP0004085_abnormal_heartbeat1.65894831
40MP0008995_early_reproductive_senescence1.60893955
41MP0008058_abnormal_DNA_repair1.60272103
42MP0003221_abnormal_cardiomyocyte_apopto1.52137113
43MP0002108_abnormal_muscle_morphology1.50845841
44MP0008057_abnormal_DNA_replication1.49854420
45MP0005623_abnormal_meninges_morphology1.44853488
46MP0003941_abnormal_skin_development1.44530903
47MP0000733_abnormal_muscle_development1.41618469
48MP0010094_abnormal_chromosome_stability1.41295043
49MP0001984_abnormal_olfaction1.27544375
50MP0009046_muscle_twitch1.25105812
51MP0003567_abnormal_fetal_cardiomyocyte1.14177126
52MP0004233_abnormal_muscle_weight1.11346136
53MP0000013_abnormal_adipose_tissue1.08191934
54MP0003111_abnormal_nucleus_morphology1.06919641
55MP0005647_abnormal_sex_gland1.04437818
56MP0003786_premature_aging1.02693726
57MP0000266_abnormal_heart_morphology1.01779946
58MP0005266_abnormal_metabolism0.96495435
59MP0002282_abnormal_trachea_morphology0.94322539
60MP0005389_reproductive_system_phenotype0.94252252
61MP0008007_abnormal_cellular_replicative0.90613265
62MP0001765_abnormal_ion_homeostasis0.80850037
63MP0003011_delayed_dark_adaptation0.79316289
64MP0003115_abnormal_respiratory_system0.76522156
65MP0003693_abnormal_embryo_hatching0.76290797
66MP0002638_abnormal_pupillary_reflex0.75210247
67MP0001299_abnormal_eye_distance/0.75120086
68MP0004270_analgesia0.74792941
69MP0008961_abnormal_basal_metabolism0.72826909
70MP0003828_pulmonary_edema0.72558203
71MP0002254_reproductive_system_inflammat0.72323432
72MP0003699_abnormal_female_reproductive0.71173427
73MP0000358_abnormal_cell_content/0.70235424
74MP0003045_fibrosis0.68841926
75MP0003077_abnormal_cell_cycle0.67902706
76MP0002128_abnormal_blood_circulation0.67029911
77MP0010030_abnormal_orbit_morphology0.66717283
78MP0010307_abnormal_tumor_latency0.65714321
79MP0002102_abnormal_ear_morphology0.62291010
80MP0003878_abnormal_ear_physiology0.61038367
81MP0005377_hearing/vestibular/ear_phenot0.61038367
82MP0002234_abnormal_pharynx_morphology0.60523058
83MP0000003_abnormal_adipose_tissue0.58669549
84MP0002971_abnormal_brown_adipose0.58412855
85MP0005375_adipose_tissue_phenotype0.57761457
86MP0004808_abnormal_hematopoietic_stem0.56692135
87MP0004147_increased_porphyrin_level0.56041560
88MP0001730_embryonic_growth_arrest0.55512152
89MP0003890_abnormal_embryonic-extraembry0.54058149
90MP0001119_abnormal_female_reproductive0.53562137
91MP0003329_amyloid_beta_deposits0.51998208
92MP0010368_abnormal_lymphatic_system0.51636796
93MP0004272_abnormal_basement_membrane0.51358584
94MP0005165_increased_susceptibility_to0.50598531
95MP0002822_catalepsy0.49940307
96MP0005551_abnormal_eye_electrophysiolog0.49498144
97MP0005397_hematopoietic_system_phenotyp0.48541354
98MP0001545_abnormal_hematopoietic_system0.48541354
99MP0004043_abnormal_pH_regulation0.47589594
100MP0005451_abnormal_body_composition0.47264457
101MP0003136_yellow_coat_color0.46416434
102MP0001986_abnormal_taste_sensitivity0.45760299
103MP0009384_cardiac_valve_regurgitation0.43833961
104MP0005248_abnormal_Harderian_gland0.43367498
105MP0005187_abnormal_penis_morphology0.43085265
106MP0000579_abnormal_nail_morphology0.42815750
107MP0009250_abnormal_appendicular_skeleto0.42496018
108MP0000762_abnormal_tongue_morphology0.42319734
109MP0005636_abnormal_mineral_homeostasis0.42309771
110MP0008569_lethality_at_weaning0.42181519
111MP0004134_abnormal_chest_morphology0.40736289
112MP0000313_abnormal_cell_death0.39969661
113MP0002132_abnormal_respiratory_system0.38329541
114MP0003861_abnormal_nervous_system0.38070634
115MP0003950_abnormal_plasma_membrane0.37824282
116MP0009115_abnormal_fat_cell0.37706175
117MP0001672_abnormal_embryogenesis/_devel0.37703998
118MP0005380_embryogenesis_phenotype0.37703998
119MP0001293_anophthalmia0.36474556
120MP0004185_abnormal_adipocyte_glucose0.36353616
121MP0005666_abnormal_adipose_tissue0.35732801
122MP0003936_abnormal_reproductive_system0.35410860
123MP0004957_abnormal_blastocyst_morpholog0.35186563
124MP0002152_abnormal_brain_morphology0.35070452
125MP0002084_abnormal_developmental_patter0.35062035
126MP0002249_abnormal_larynx_morphology0.34834066
127MP0003718_maternal_effect0.34794864
128MP0006036_abnormal_mitochondrial_physio0.34413664
129MP0003385_abnormal_body_wall0.33893424
130MP0002269_muscular_atrophy0.33293188
131MP0005253_abnormal_eye_physiology0.33093785
132MP0000230_abnormal_systemic_arterial0.33038189
133MP0001727_abnormal_embryo_implantation0.32773817
134MP0000462_abnormal_digestive_system0.32745772
135MP0000534_abnormal_ureter_morphology0.32393603
136MP0004036_abnormal_muscle_relaxation0.32268626
137MP0002925_abnormal_cardiovascular_devel0.31797238
138MP0001697_abnormal_embryo_size0.31051707
139MP0009780_abnormal_chondrocyte_physiolo0.30740215
140MP0009703_decreased_birth_body0.30328865
141MP0008932_abnormal_embryonic_tissue0.30210770
142MP0001529_abnormal_vocalization0.30078032
143MP0001784_abnormal_fluid_regulation0.29922230
144MP0005332_abnormal_amino_acid0.29855963
145MP0001849_ear_inflammation0.29838861
146MP0003937_abnormal_limbs/digits/tail_de0.29703914
147MP0009278_abnormal_bone_marrow0.29053299
148MP0002078_abnormal_glucose_homeostasis0.28883186
149MP0005391_vision/eye_phenotype0.28715586
150MP0004019_abnormal_vitamin_homeostasis0.28585864
151MP0003879_abnormal_hair_cell0.27957180
152MP0002697_abnormal_eye_size0.27658099
153MP0003279_aneurysm0.26392780
154MP0002169_no_abnormal_phenotype0.25855666
155MP0001661_extended_life_span0.25847400
156MP0000631_abnormal_neuroendocrine_gland0.25842740
157MP0004811_abnormal_neuron_physiology0.25812795
158MP0003948_abnormal_gas_homeostasis0.25677332
159MP0002873_normal_phenotype0.25390927
160MP0001324_abnormal_eye_pigmentation0.24846476
161MP0002928_abnormal_bile_duct0.24812636
162MP0004197_abnormal_fetal_growth/weight/0.24487492
163MP0003984_embryonic_growth_retardation0.24399756
164MP0001614_abnormal_blood_vessel0.24336050
165MP0002085_abnormal_embryonic_tissue0.23605675
166MP0006072_abnormal_retinal_apoptosis0.23588193
167MP0008789_abnormal_olfactory_epithelium0.23451744
168MP0002080_prenatal_lethality0.23114881
169MP0002736_abnormal_nociception_after0.22553320
170MP0006035_abnormal_mitochondrial_morpho0.22349969
171MP0000350_abnormal_cell_proliferation0.21943596
172MP0009672_abnormal_birth_weight0.21345394
173MP0002088_abnormal_embryonic_growth/wei0.21336463
174MP0001764_abnormal_homeostasis0.20270317
175MP0000432_abnormal_head_morphology0.19695956
176MP0000001_mammalian_phenotype0.19695805
177MP0005195_abnormal_posterior_eye0.19531868

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.32562719
2Muscle fiber inclusion bodies (HP:0100299)9.07206724
3Nemaline bodies (HP:0003798)9.05908697
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.00948872
5Abnormal respiratory epithelium morphology (HP:0012253)8.75559257
6Abnormal respiratory motile cilium morphology (HP:0005938)8.75559257
7Rhinitis (HP:0012384)7.96941372
8Chronic bronchitis (HP:0004469)7.47201359
9Type 1 muscle fiber predominance (HP:0003803)7.45690393
10Abnormal ciliary motility (HP:0012262)7.14507761
11Exercise-induced muscle cramps (HP:0003710)6.67103756
12Infertility (HP:0000789)6.56373602
13Exercise-induced myalgia (HP:0003738)6.51894704
14Nasal polyposis (HP:0100582)6.08765682
15Muscle hypertrophy of the lower extremities (HP:0008968)6.06657769
16Sudden death (HP:0001699)5.89415394
17Calf muscle hypertrophy (HP:0008981)5.57640904
18Abnormality of the left ventricular outflow tract (HP:0011103)5.54663234
19Subaortic stenosis (HP:0001682)5.54663234
20Muscle fiber splitting (HP:0003555)5.53287217
21Abnormality of the calf musculature (HP:0001430)5.37002577
22Hyporeflexia of lower limbs (HP:0002600)5.19228808
23EMG: myopathic abnormalities (HP:0003458)5.18311637
24Ventricular tachycardia (HP:0004756)5.18043680
25Bundle branch block (HP:0011710)5.15933269
26Abnormality of the nasal mucosa (HP:0000433)4.92694513
27Centrally nucleated skeletal muscle fibers (HP:0003687)4.60580994
28Bronchiectasis (HP:0002110)4.47753647
29Myopathic facies (HP:0002058)4.46431475
30Myoglobinuria (HP:0002913)4.46253535
31Nephronophthisis (HP:0000090)4.38926396
32Rhabdomyolysis (HP:0003201)4.36259770
33Rimmed vacuoles (HP:0003805)4.31975768
34Bronchitis (HP:0012387)4.30377525
35Neck muscle weakness (HP:0000467)4.23745492
36Asymmetric septal hypertrophy (HP:0001670)4.10402807
37Lipoatrophy (HP:0100578)4.02459679
38Dilated cardiomyopathy (HP:0001644)3.98262321
39Distal lower limb muscle weakness (HP:0009053)3.92577370
40Distal arthrogryposis (HP:0005684)3.86932046
41Male infertility (HP:0003251)3.67612073
42Atrial fibrillation (HP:0005110)3.67064840
43Abnormality of skeletal muscle fiber size (HP:0012084)3.63317696
44Difficulty running (HP:0009046)3.63313765
45EMG: neuropathic changes (HP:0003445)3.47979609
46Round ear (HP:0100830)3.46203295
47Increased connective tissue (HP:0009025)3.40127388
48Abnormality of the renal medulla (HP:0100957)3.35130312
49Areflexia of lower limbs (HP:0002522)3.34279774
50Heart block (HP:0012722)3.32524477
51Primary atrial arrhythmia (HP:0001692)3.27930430
52Ventricular arrhythmia (HP:0004308)3.25803657
53Recurrent otitis media (HP:0000403)3.24528976
54Abnormal spermatogenesis (HP:0008669)3.20902788
55Supraventricular tachycardia (HP:0004755)3.18541602
56Syncope (HP:0001279)3.16468275
57Abnormality of the lower motor neuron (HP:0002366)3.11491354
58Right ventricular cardiomyopathy (HP:0011663)3.10367722
59Mildly elevated creatine phosphokinase (HP:0008180)3.10076772
60Muscle stiffness (HP:0003552)3.09813566
61Supraventricular arrhythmia (HP:0005115)3.09813497
62Abnormal atrioventricular conduction (HP:0005150)3.09136468
63Increased variability in muscle fiber diameter (HP:0003557)3.08852780
64Myotonia (HP:0002486)3.03961248
65Ulnar deviation of the wrist (HP:0003049)3.03597039
66Palpitations (HP:0001962)2.98611214
67Gonadotropin excess (HP:0000837)2.94343004
68Impulsivity (HP:0100710)2.89844096
69Recurrent sinusitis (HP:0011108)2.88323935
70Calcaneovalgus deformity (HP:0001848)2.85360348
71Tubular atrophy (HP:0000092)2.83328975
72Generalized muscle weakness (HP:0003324)2.77093200
73Frequent falls (HP:0002359)2.64124864
74Tubulointerstitial nephritis (HP:0001970)2.63036511
75Hip contracture (HP:0003273)2.60903956
76Distal lower limb amyotrophy (HP:0008944)2.57489190
77Progressive muscle weakness (HP:0003323)2.55741028
78Ragged-red muscle fibers (HP:0003200)2.54912437
79Azoospermia (HP:0000027)2.51733714
80Deformed tarsal bones (HP:0008119)2.50748026
81Molar tooth sign on MRI (HP:0002419)2.45381895
82Abnormality of midbrain morphology (HP:0002418)2.45381895
83Scapular winging (HP:0003691)2.43296668
84Absent phalangeal crease (HP:0006109)2.39220752
85Proximal amyotrophy (HP:0007126)2.38470366
86Medial flaring of the eyebrow (HP:0010747)2.32874400
87Left ventricular hypertrophy (HP:0001712)2.32326412
88Abnormality of the foot musculature (HP:0001436)2.27035260
89Atrioventricular block (HP:0001678)2.26358678
90Tubulointerstitial abnormality (HP:0001969)2.26215318
91Amyotrophic lateral sclerosis (HP:0007354)2.26203018
92Difficulty climbing stairs (HP:0003551)2.25230780
93Recurrent bronchitis (HP:0002837)2.19161636
94Abnormality of dentin (HP:0010299)2.14055039
95Abnormality of the shoulder girdle musculature (HP:0001435)2.13640728
96Malignant hyperthermia (HP:0002047)2.13479176
97Ventricular fibrillation (HP:0001663)2.11994122
98Muscular dystrophy (HP:0003560)2.11328694
99Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10751694
100Abnormal EKG (HP:0003115)2.08997856
101Gowers sign (HP:0003391)2.08869503
102Fibular hypoplasia (HP:0003038)2.08459616
103Prolonged QT interval (HP:0001657)2.07786407
104Bulbar palsy (HP:0001283)2.02094872
105Postaxial foot polydactyly (HP:0001830)2.01451561
106Limb-girdle muscle atrophy (HP:0003797)2.00958899
107Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4400995
108Dynein arm defect of respiratory motile cilia (HP:0012255)12.3102213
109Absent/shortened dynein arms (HP:0200106)12.3102213
110Stage 5 chronic kidney disease (HP:0003774)1.99505216
111Lower limb amyotrophy (HP:0007210)1.98220245
112Weak cry (HP:0001612)1.94394478
113Hyperkalemia (HP:0002153)1.94241717
114Tubulointerstitial fibrosis (HP:0005576)1.92480318
115Abnormal gallbladder physiology (HP:0012438)1.90542868
116Cholecystitis (HP:0001082)1.90542868
117Spastic tetraparesis (HP:0001285)1.90484187
118Foot dorsiflexor weakness (HP:0009027)1.89803579
119Waddling gait (HP:0002515)1.88992918
120Abnormal finger flexion creases (HP:0006143)1.88260278
121Exercise intolerance (HP:0003546)1.84072608
122Abnormality of the renal cortex (HP:0011035)1.84012569
123Upper motor neuron abnormality (HP:0002127)1.82272404
124Short ribs (HP:0000773)1.80828638
125Increased intramyocellular lipid droplets (HP:0012240)1.80678644
126Impaired proprioception (HP:0010831)1.79713259
127Fatigable weakness (HP:0003473)1.79357879
128Abnormality of the neuromuscular junction (HP:0003398)1.79357879
129Abnormality of the dental pulp (HP:0006479)1.78487535
130Limited hip movement (HP:0008800)1.77284848
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76282646
132Absent epiphyses (HP:0010577)1.76282646
133Dyschromatopsia (HP:0007641)1.75597363
134Congenital hepatic fibrosis (HP:0002612)1.75411419
135Heterotopia (HP:0002282)1.73582646
136Renal dysplasia (HP:0000110)1.73556049
137Palmoplantar keratoderma (HP:0000982)1.73494350
138Microglossia (HP:0000171)1.69011542
139Slender build (HP:0001533)1.67887390
140Dysmetric saccades (HP:0000641)1.67300129
141Supernumerary spleens (HP:0009799)1.67230338
142Increased muscle lipid content (HP:0009058)1.66400911
143Spinal rigidity (HP:0003306)1.63163402
144Oculomotor apraxia (HP:0000657)1.63106432
145Abnormality of the calcaneus (HP:0008364)1.62803222
146Abnormal drinking behavior (HP:0030082)1.62357222
147Polydipsia (HP:0001959)1.62357222
148Facial diplegia (HP:0001349)1.61059693
149Hypoplastic left heart (HP:0004383)1.59471464
150Sensory axonal neuropathy (HP:0003390)1.59406990
151Respiratory insufficiency due to muscle weakness (HP:0002747)1.57804775
152Degeneration of anterior horn cells (HP:0002398)1.57109296
153Abnormality of the anterior horn cell (HP:0006802)1.57109296
154Decreased central vision (HP:0007663)1.56438827
155Hypoplastic heart (HP:0001961)1.55575461
156Abnormality of the dental root (HP:0006486)1.55511831
157Taurodontia (HP:0000679)1.55511831
158Abnormality of permanent molar morphology (HP:0011071)1.55511831
159Short femoral neck (HP:0100864)1.55471682
160Limb-girdle muscle weakness (HP:0003325)1.51652893
161Abnormality of the sella turcica (HP:0002679)1.50500392
162Bell-shaped thorax (HP:0001591)1.49420854
163Absent frontal sinuses (HP:0002688)1.48932631
164Aplasia/Hypoplasia of the fibula (HP:0006492)1.45384293
165Abnormality of molar morphology (HP:0011070)1.45113470
166Abnormality of molar (HP:0011077)1.45113470
167Steppage gait (HP:0003376)1.44282429
168Short thorax (HP:0010306)1.44073343
169Abnormality of renal excretion (HP:0011036)1.43931226
170Postaxial hand polydactyly (HP:0001162)1.43869539
171Pancreatic fibrosis (HP:0100732)1.41681802
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.40691221
173Hyperglycinuria (HP:0003108)1.40091571
174Increased serum pyruvate (HP:0003542)1.39420248
175Facial cleft (HP:0002006)1.38547643
176J-shaped sella turcica (HP:0002680)1.38051541
177Chronic sinusitis (HP:0011109)1.37517513
178Choroideremia (HP:0001139)1.37450220
179Abnormal biliary tract physiology (HP:0012439)1.36905232
180Bile duct proliferation (HP:0001408)1.36905232
181Aplasia/Hypoplasia of the lens (HP:0008063)1.36822098
182Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.33209491
183Cystic liver disease (HP:0006706)1.33158519
184True hermaphroditism (HP:0010459)1.28947318
185Congenital primary aphakia (HP:0007707)1.25767898
186Gait imbalance (HP:0002141)1.25521015
187Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24575117
188Deformed sella turcica (HP:0002681)1.24441526
189Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.24295612
190Aplasia/Hypoplasia of the uvula (HP:0010293)1.23117455
191Chromosomal breakage induced by crosslinking agents (HP:0003221)1.23094548
192Congenital malformation of the right heart (HP:0011723)1.21665769
193Double outlet right ventricle (HP:0001719)1.21665769
194Sloping forehead (HP:0000340)1.21234361
195Median cleft lip (HP:0000161)1.20082180
196Short nail (HP:0001799)1.19528501
197Easy fatigability (HP:0003388)1.18368160
198Breast carcinoma (HP:0003002)1.18014794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.68780504
2PDK48.40935490
3PDK38.40935490
4TTN6.75140225
5TESK15.58903177
6PDK25.44808930
7PHKG24.98879611
8PHKG14.98879611
9PRKD34.09991167
10ICK3.60327101
11WNK42.88316838
12STK392.34899527
13MYLK2.31497505
14DMPK2.22009383
15PIK3CG2.20077067
16NEK22.20067685
17PTK2B2.02089953
18PNCK2.00103542
19MAPK121.86801295
20MAP3K71.84288798
21STK381.72924916
22PKN21.56332409
23NME11.56283460
24MAPKAPK31.56199334
25WNK11.41681592
26TRPM71.14160952
27PIK3CA1.06700544
28DYRK31.06385272
29MAPK151.04199532
30DYRK1B1.02999521
31STK31.01220193
32PDK10.99593415
33MAP2K30.97386035
34FLT30.93326582
35CAMK2D0.93192626
36CAMK10.92128352
37PRKAA20.90494189
38CCNB10.88046814
39TYRO30.87050327
40CAMK40.85501124
41CDC70.84643003
42TAOK10.84509396
43MARK10.79524124
44PINK10.78667529
45TTK0.77289083
46CAMK2G0.76740502
47AKT20.76467728
48BCKDK0.76394549
49MAP2K40.73126625
50KSR20.73070851
51CAMK2A0.72804784
52CDK120.72782641
53WEE10.71611492
54STK38L0.70832162
55PRKD10.69916428
56LIMK10.69270859
57CHEK20.68320120
58NEK10.65472422
59ROCK10.64219076
60DAPK20.62264906
61TIE10.60887269
62PAK30.60603830
63NLK0.58932854
64PASK0.58374514
65NEK90.56974117
66PRKG10.53567525
67CHEK10.52083399
68NTRK20.49725045
69STK240.48562178
70MAPK70.48324770
71PLK10.47781450
72MAPK40.47602392
73LMTK20.45784591
74MAP2K10.44957820
75PLK40.44150378
76TESK20.43866434
77CAMK2B0.43756592
78PDPK10.43439132
79FGFR10.42807896
80PKN10.42569080
81PRKACA0.42394584
82RPS6KB20.41485704
83LATS10.41221599
84ERBB30.41072738
85ATR0.41070474
86IRAK10.41028084
87MUSK0.40934019
88MAP3K50.38349107
89ATM0.36807004
90RIPK10.34778807
91PAK10.34352316
92DAPK30.32653638
93TNIK0.32237882
94PRKACB0.31173198
95CDC42BPA0.31149858
96MTOR0.30814465
97FGFR20.29493043
98RPS6KA30.29198914
99PRKACG0.28442745
100PRKCE0.28132068
101MAP3K100.27916022
102NEK60.26651352
103PRKCG0.26414637
104MAP3K130.25365990
105BMPR1B0.25064585
106BRSK20.25000584
107STK100.24202913
108RPS6KL10.24097022
109RPS6KC10.24097022
110AURKA0.23774120
111PRKAA10.22769166
112BRAF0.22592384
113WNK30.22525851
114CAMK1G0.21780379
115RPS6KA10.21566543
116MAP3K60.20602931
117TRIB30.20513004
118SGK20.20134093
119EEF2K0.19569377
120PRKDC0.19022118
121MAP3K90.18103519
122LATS20.18024522
123RPS6KB10.17476770
124PAK60.17336902
125RPS6KA60.16786527
126TEC0.16158158
127UHMK10.15630571
128BUB10.15322484
129AKT30.14494072
130SGK10.14221665
131CDK40.14046626
132PAK20.12792876
133GRK70.12347647
134ACVR1B0.12319895
135MAP3K40.12276265
136GRK50.12190921
137SGK2230.11948230
138SGK4940.11948230
139MET0.11760696
140BRSK10.11668341
141FER0.11028669
142MARK20.10635388
143MAP2K70.10118670
144YES10.09955190
145MOS0.09847016
146CDK70.09542417
147STK40.09461660
148CDK10.09437278
149EPHA40.09199727
150MAP3K110.09146426
151CDK20.09047755
152PRKCZ0.08403800
153ROCK20.08236970
154BMX0.07880960
155CSNK2A10.07495844
156GSK3B0.07483114
157GRK10.07383548
158RIPK40.07332993
159CAMKK10.06720833
160PLK30.05943006
161IRAK20.05926494
162MARK30.05685475
163MAP2K60.05401364
164MAPK100.04842253
165DYRK1A0.03576032
166SGK30.03543826
167PDGFRB0.03370731
168STK160.03102998
169PIM10.02642170
170AURKB0.02178172
171MAP3K30.02160749
172EIF2AK20.02079851
173STK110.01719068

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.00754027
2Vitamin B6 metabolism_Homo sapiens_hsa007504.55973984
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.52687731
4Dilated cardiomyopathy_Homo sapiens_hsa054144.46754938
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.30060395
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.00955202
7Pyruvate metabolism_Homo sapiens_hsa006203.55171625
8Fatty acid biosynthesis_Homo sapiens_hsa000613.40339975
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.33833612
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.27450137
11Linoleic acid metabolism_Homo sapiens_hsa005913.16184490
12Basal transcription factors_Homo sapiens_hsa030223.13418725
13Glucagon signaling pathway_Homo sapiens_hsa049222.68807662
14Fanconi anemia pathway_Homo sapiens_hsa034602.67215018
15Pentose phosphate pathway_Homo sapiens_hsa000302.55078327
16Propanoate metabolism_Homo sapiens_hsa006402.44370832
17Selenocompound metabolism_Homo sapiens_hsa004502.41789818
18Dorso-ventral axis formation_Homo sapiens_hsa043202.16256585
19Circadian rhythm_Homo sapiens_hsa047102.13864007
20Oocyte meiosis_Homo sapiens_hsa041142.05577437
21Arginine biosynthesis_Homo sapiens_hsa002201.94628402
22Glycerolipid metabolism_Homo sapiens_hsa005611.82447370
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79849039
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79472517
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.78574201
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.72418695
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71489875
28Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.70869307
29Huntingtons disease_Homo sapiens_hsa050161.67092084
30Fructose and mannose metabolism_Homo sapiens_hsa000511.63794460
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.63411679
32Arginine and proline metabolism_Homo sapiens_hsa003301.59828063
33Amphetamine addiction_Homo sapiens_hsa050311.51694785
34RNA transport_Homo sapiens_hsa030131.51372673
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50980092
36mRNA surveillance pathway_Homo sapiens_hsa030151.49336060
37Ether lipid metabolism_Homo sapiens_hsa005651.44605023
38Fat digestion and absorption_Homo sapiens_hsa049751.44136870
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38918628
40Parkinsons disease_Homo sapiens_hsa050121.34895987
41Carbon metabolism_Homo sapiens_hsa012001.32776686
42PPAR signaling pathway_Homo sapiens_hsa033201.32264868
43Insulin signaling pathway_Homo sapiens_hsa049101.29963723
44Phenylalanine metabolism_Homo sapiens_hsa003601.28808226
45Cardiac muscle contraction_Homo sapiens_hsa042601.23290508
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20009547
47Purine metabolism_Homo sapiens_hsa002301.18861151
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17777294
49Tight junction_Homo sapiens_hsa045301.17156212
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16176377
51Mineral absorption_Homo sapiens_hsa049781.12966974
52Oxytocin signaling pathway_Homo sapiens_hsa049211.12809503
53Biosynthesis of amino acids_Homo sapiens_hsa012301.04565838
54Insulin resistance_Homo sapiens_hsa049311.04233085
55Alzheimers disease_Homo sapiens_hsa050101.00533803
56Oxidative phosphorylation_Homo sapiens_hsa001900.97140161
57Renin secretion_Homo sapiens_hsa049240.95863511
58Arachidonic acid metabolism_Homo sapiens_hsa005900.95646278
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95487370
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.90030658
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88639547
62Homologous recombination_Homo sapiens_hsa034400.87454999
63Fatty acid metabolism_Homo sapiens_hsa012120.87178815
64Antigen processing and presentation_Homo sapiens_hsa046120.85616972
65Starch and sucrose metabolism_Homo sapiens_hsa005000.81231457
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79928561
67Adherens junction_Homo sapiens_hsa045200.79453731
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.78782380
69Glutathione metabolism_Homo sapiens_hsa004800.78073939
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77602869
71Pyrimidine metabolism_Homo sapiens_hsa002400.75513087
72Nitrogen metabolism_Homo sapiens_hsa009100.73062763
73Hedgehog signaling pathway_Homo sapiens_hsa043400.73000937
74Butanoate metabolism_Homo sapiens_hsa006500.71712797
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70377788
76Cell cycle_Homo sapiens_hsa041100.67034154
77Long-term potentiation_Homo sapiens_hsa047200.66527815
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66260163
79Viral myocarditis_Homo sapiens_hsa054160.65794033
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65033631
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63798683
82Fatty acid elongation_Homo sapiens_hsa000620.62738278
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62566040
84Fatty acid degradation_Homo sapiens_hsa000710.62420195
85Estrogen signaling pathway_Homo sapiens_hsa049150.62219324
86Collecting duct acid secretion_Homo sapiens_hsa049660.61341606
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61176363
88Systemic lupus erythematosus_Homo sapiens_hsa053220.61074153
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58228755
90Focal adhesion_Homo sapiens_hsa045100.57425329
91Galactose metabolism_Homo sapiens_hsa000520.57349782
92RNA degradation_Homo sapiens_hsa030180.55437388
93Lysine degradation_Homo sapiens_hsa003100.55417108
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54269546
95AMPK signaling pathway_Homo sapiens_hsa041520.53461446
96Synaptic vesicle cycle_Homo sapiens_hsa047210.53420814
97ABC transporters_Homo sapiens_hsa020100.51980301
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51073054
99Tryptophan metabolism_Homo sapiens_hsa003800.50941334
100beta-Alanine metabolism_Homo sapiens_hsa004100.49185114
101Chemical carcinogenesis_Homo sapiens_hsa052040.47941112
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.47721168
103N-Glycan biosynthesis_Homo sapiens_hsa005100.47250242
104Circadian entrainment_Homo sapiens_hsa047130.46866523
105Insulin secretion_Homo sapiens_hsa049110.46794150
106Calcium signaling pathway_Homo sapiens_hsa040200.46411052
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45856142
108Metabolic pathways_Homo sapiens_hsa011000.44723416
109Legionellosis_Homo sapiens_hsa051340.42333943
110Inositol phosphate metabolism_Homo sapiens_hsa005620.42234777
111Sphingolipid metabolism_Homo sapiens_hsa006000.41190736
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.40544504
113Tyrosine metabolism_Homo sapiens_hsa003500.40303565
114Endocytosis_Homo sapiens_hsa041440.40184243
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38270446
116VEGF signaling pathway_Homo sapiens_hsa043700.34532406
117Peroxisome_Homo sapiens_hsa041460.33463169
118GnRH signaling pathway_Homo sapiens_hsa049120.33343249
119Wnt signaling pathway_Homo sapiens_hsa043100.32743945
120ECM-receptor interaction_Homo sapiens_hsa045120.32711374
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32297922
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30948767
123Thyroid hormone synthesis_Homo sapiens_hsa049180.29692631
124Protein digestion and absorption_Homo sapiens_hsa049740.28985697
125Thyroid cancer_Homo sapiens_hsa052160.28483296
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28158825
127Alcoholism_Homo sapiens_hsa050340.26814047
128Melanogenesis_Homo sapiens_hsa049160.26162306
129Salivary secretion_Homo sapiens_hsa049700.25513867
130Pancreatic secretion_Homo sapiens_hsa049720.25312497
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24290203
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23101405
133Base excision repair_Homo sapiens_hsa034100.22851415
134GABAergic synapse_Homo sapiens_hsa047270.22766752
135Gastric acid secretion_Homo sapiens_hsa049710.22633899
136Ovarian steroidogenesis_Homo sapiens_hsa049130.21796063
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21406258
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21221665
139cAMP signaling pathway_Homo sapiens_hsa040240.19969844
140Basal cell carcinoma_Homo sapiens_hsa052170.19835583
141Cholinergic synapse_Homo sapiens_hsa047250.19730771
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19374639
143p53 signaling pathway_Homo sapiens_hsa041150.19263880
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17821021
145HIF-1 signaling pathway_Homo sapiens_hsa040660.17142670
146Hippo signaling pathway_Homo sapiens_hsa043900.16647329
147Long-term depression_Homo sapiens_hsa047300.16564531
148Bile secretion_Homo sapiens_hsa049760.16539711
149Taste transduction_Homo sapiens_hsa047420.15067751
150Histidine metabolism_Homo sapiens_hsa003400.14900474
151Amoebiasis_Homo sapiens_hsa051460.13723745
152FoxO signaling pathway_Homo sapiens_hsa040680.11865563
153MAPK signaling pathway_Homo sapiens_hsa040100.11429373
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.11009348
155Gap junction_Homo sapiens_hsa045400.10480056

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