ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	binding of sperm to zona pellucida (GO:0007339)	9.74194508
2	axonemal dynein complex assembly (GO:0070286)	9.63740614
3	epithelial cilium movement (GO:0003351)	8.92646151
4	spermatid development (GO:0007286)	8.51234761
5	single fertilization (GO:0007338)	7.87301493
6	piRNA metabolic process (GO:0034587)	7.46705899
7	cilium movement (GO:0003341)	7.36705655
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.35102900
9	regulation of cilium movement (GO:0003352)	6.95635956
10	male meiosis (GO:0007140)	6.87453538
11	sperm capacitation (GO:0048240)	6.40836780
12	fertilization (GO:0009566)	6.29187663
13	synaptonemal complex organization (GO:0070193)	6.28597389
14	microtubule depolymerization (GO:0007019)	6.23411331
15	synaptonemal complex assembly (GO:0007130)	6.05082525
16	spermatogenesis (GO:0007283)	5.56803041
17	male gamete generation (GO:0048232)	5.54563212
18	organic cation transport (GO:0015695)	5.53565586
19	negative regulation of inclusion body assembly (GO:0090084)	5.20574071
20	cell recognition (GO:0008037)	5.16008680
21	calcium ion-dependent exocytosis (GO:0017156)	5.14703213
22	gamete generation (GO:0007276)	5.10172909
23	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.01085659
24	spermatid nucleus differentiation (GO:0007289)	4.92918933
25	germ cell development (GO:0007281)	4.75484083
26	ventricular system development (GO:0021591)	4.71363042
27	DNA methylation involved in gamete generation (GO:0043046)	4.60968505
28	regulation of inclusion body assembly (GO:0090083)	4.45840140
29	male meiosis I (GO:0007141)	4.32649145
30	regulation of microtubule-based movement (GO:0060632)	4.10532886
31	chromosome organization involved in meiosis (GO:0070192)	4.10383519
32	meiotic nuclear division (GO:0007126)	4.05980189
33	multicellular organismal reproductive process (GO:0048609)	4.01544879
34	chaperone-mediated protein complex assembly (GO:0051131)	3.93322868
35	glycerol ether metabolic process (GO:0006662)	3.77890997
36	left/right pattern formation (GO:0060972)	3.66998564
37	monoubiquitinated protein deubiquitination (GO:0035520)	3.66959512
38	centriole assembly (GO:0098534)	3.63165576
39	seminiferous tubule development (GO:0072520)	3.57826339
40	microtubule severing (GO:0051013)	3.57330612
41	protein localization to cilium (GO:0061512)	3.47698968
42	ether metabolic process (GO:0018904)	3.47095501
43	meiosis I (GO:0007127)	3.44378427
44	microtubule polymerization or depolymerization (GO:0031109)	3.41581022
45	centriole replication (GO:0007099)	3.33749003
46	chromosome condensation (GO:0030261)	3.29625287
47	meiotic cell cycle (GO:0051321)	3.25244541
48	multicellular organismal development (GO:0007275)	3.24107139
49	amino-acid betaine transport (GO:0015838)	3.07150653
50	carnitine transport (GO:0015879)	3.07150653
51	DNA packaging (GO:0006323)	3.05858237
52	regulation of podosome assembly (GO:0071801)	3.03434900
53	alditol metabolic process (GO:0019400)	2.97438016
54	single-organism membrane fusion (GO:0044801)	2.96343378
55	polyol catabolic process (GO:0046174)	2.95352183
56	protein K11-linked deubiquitination (GO:0035871)	2.93398455
57	carnitine transmembrane transport (GO:1902603)	2.92342225
58	gene silencing by RNA (GO:0031047)	2.89797678
59	cilium morphogenesis (GO:0060271)	2.87939489
60	regulation of spindle checkpoint (GO:0090231)	2.86382197
61	positive regulation of macrophage activation (GO:0043032)	2.86382136
62	microtubule-based movement (GO:0007018)	2.82744125
63	peptidyl-threonine dephosphorylation (GO:0035970)	2.77916708
64	macroautophagy (GO:0016236)	2.76251423
65	axoneme assembly (GO:0035082)	2.75936606
66	intraciliary transport (GO:0042073)	2.73544711
67	regulation of centriole replication (GO:0046599)	2.73420590
68	genitalia morphogenesis (GO:0035112)	2.73110447
69	glycerol metabolic process (GO:0006071)	2.70421623
70	cilium organization (GO:0044782)	2.64672908
71	cellular component assembly involved in morphogenesis (GO:0010927)	2.63387106
72	nuclear pore complex assembly (GO:0051292)	2.61421654
73	cilium assembly (GO:0042384)	2.57457147
74	nucleus organization (GO:0006997)	2.54924252
75	nucleoside diphosphate phosphorylation (GO:0006165)	2.51691069
76	sequestering of actin monomers (GO:0042989)	2.50001116
77	protein polyglutamylation (GO:0018095)	2.41923255
78	single strand break repair (GO:0000012)	2.41243325
79	glycolytic process (GO:0006096)	2.36733283
80	meiotic cell cycle process (GO:1903046)	2.36364028
81	regulation of cilium assembly (GO:1902017)	2.34357308
82	protein refolding (GO:0042026)	2.33327574
83	synapsis (GO:0007129)	2.32996970
84	lactate metabolic process (GO:0006089)	2.32524964
85	cellular response to arsenic-containing substance (GO:0071243)	2.29286463
86	negative regulation of organelle assembly (GO:1902116)	2.26386004
87	mitotic sister chromatid cohesion (GO:0007064)	2.26029486
88	fusion of sperm to egg plasma membrane (GO:0007342)	16.8737745
89	cell wall macromolecule catabolic process (GO:0016998)	16.8334596
90	cell wall macromolecule metabolic process (GO:0044036)	16.8334596
91	cilium or flagellum-dependent cell motility (GO:0001539)	13.2163040
92	multicellular organism reproduction (GO:0032504)	13.0340711
93	plasma membrane fusion (GO:0045026)	12.8547557
94	acrosome assembly (GO:0001675)	11.9835059
95	sperm-egg recognition (GO:0035036)	11.8068287
96	sperm motility (GO:0030317)	10.9683637
97	reproduction (GO:0000003)	10.6338516
98	cell-cell recognition (GO:0009988)	10.5786768
99	acrosome reaction (GO:0007340)	10.4701201
100	motile cilium assembly (GO:0044458)	10.1649542

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.10803589
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.77137990
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.48775045
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26122001
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22927492
6	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.16106020
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.13899517
8	ELK4_26923725_Chip-Seq_MESODERM_Mouse	2.08334064
9	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.04535119
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00865841
11	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	11.0077720
12	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.99837011
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.98544957
14	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.90579656
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89149739
16	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.88124706
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.82505753
18	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.79135856
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79034342
20	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.78626717
21	VDR_22108803_ChIP-Seq_LS180_Human	1.69748638
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.69242823
23	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.65533002
24	STAT1_17558387_ChIP-Seq_HELA_Human	1.64858936
25	KDM2B_26808549_Chip-Seq_REH_Human	1.64700931
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62045075
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56437452
28	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.52171068
29	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.51851281
30	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.46224650
31	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44411345
32	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.44248674
33	* TAL1_26923725_Chip-Seq_HPCs_Mouse	1.42782288
34	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.42175657
35	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.40097568
36	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36870266
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35764084
38	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35523731
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31131706
40	GF1_26923725_Chip-Seq_HPCs_Mouse	1.29097041
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27835230
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.27418494
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27418494
44	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24092048
45	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.23104805
46	* SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.22454383
47	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.21934470
48	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19642660
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15149789
50	P53_21459846_ChIP-Seq_SAOS-2_Human	1.14486838
51	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.13641736
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13279989
53	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13207865
54	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12536991
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12178724
56	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.11795788
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.11057707
58	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10481493
59	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.08010720
60	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.07798860
61	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.07758675
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07621268
63	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.07249520
64	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.05329708
65	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.05047097
66	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.05038751
67	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05019531
68	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04981921
69	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.04558430
70	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.04353214
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03373197
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02434530
73	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.02388927
74	P300_18555785_Chip-Seq_ESCs_Mouse	1.02117904
75	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.01411536
76	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.01049194
77	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00440802
78	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98579238
79	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.98202875
80	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.98001402
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97892488
82	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.96061764
83	PU1_27457419_Chip-Seq_LIVER_Mouse	0.95202436
84	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.94379387
85	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.92857703
86	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.92039792
87	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91652423
88	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.91438193
89	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.90678532
90	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.89971593
91	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89785840
92	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.89665826
93	ER_23166858_ChIP-Seq_MCF-7_Human	0.89146045
94	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.88703185
95	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.88330092
96	NFYB_21822215_ChIP-Seq_K562_Human	0.88029693
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.87452924
98	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.87370923
99	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.87011135
100	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86387602

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	5.55818657
2	MP0001929_abnormal_gametogenesis	5.08477672
3	MP0008877_abnormal_DNA_methylation	4.17362070
4	MP0002653_abnormal_ependyma_morphology	3.56226356
5	MP0002210_abnormal_sex_determination	3.27027595
6	MP0002161_abnormal_fertility/fecundity	3.00315791
7	MP0001145_abnormal_male_reproductive	2.77250523
8	MP0004233_abnormal_muscle_weight	2.43687148
9	MP0005623_abnormal_meninges_morphology	2.41569995
10	MP0000653_abnormal_sex_gland	2.39999299
11	MP0005670_abnormal_white_adipose	2.21680417
12	MP0005410_abnormal_fertilization	15.2947590
13	MP0002282_abnormal_trachea_morphology	1.72942453
14	MP0002234_abnormal_pharynx_morphology	1.43170711
15	MP0002160_abnormal_reproductive_system	1.34136209
16	MP0003705_abnormal_hypodermis_morpholog	1.32600162
17	MP0005257_abnormal_intraocular_pressure	1.32309201
18	MP0002102_abnormal_ear_morphology	1.27704240
19	MP0009046_muscle_twitch	1.26006938
20	MP0005275_abnormal_skin_tensile	1.17161523
21	MP0010307_abnormal_tumor_latency	1.10595752
22	MP0001984_abnormal_olfaction	1.05145051
23	MP0003279_aneurysm	1.02005173
24	MP0008438_abnormal_cutaneous_collagen	0.96557071
25	MP0003646_muscle_fatigue	0.90041367
26	MP0006082_CNS_inflammation	0.88404993
27	MP0003303_peritoneal_inflammation	0.86193396
28	MP0003011_delayed_dark_adaptation	0.81589355
29	MP0003950_abnormal_plasma_membrane	0.80527241
30	MP0001765_abnormal_ion_homeostasis	0.79250794
31	MP0000604_amyloidosis	0.77392919
32	MP0005503_abnormal_tendon_morphology	0.73953420
33	MP0002928_abnormal_bile_duct	0.73152905
34	MP0002269_muscular_atrophy	0.69241435
35	MP0005647_abnormal_sex_gland	0.68539940
36	MP0005389_reproductive_system_phenotype	0.64723290
37	MP0004134_abnormal_chest_morphology	0.64609563
38	MP0005058_abnormal_lysosome_morphology	0.61224503
39	MP0002405_respiratory_system_inflammati	0.60004821
40	MP0003436_decreased_susceptibility_to	0.59311978
41	MP0003115_abnormal_respiratory_system	0.58874594
42	MP0000358_abnormal_cell_content/	0.58563109
43	MP0001324_abnormal_eye_pigmentation	0.54785254
44	MP0010352_gastrointestinal_tract_polyps	0.54029259
45	MP0008058_abnormal_DNA_repair	0.47770058
46	MP0003566_abnormal_cell_adhesion	0.46589396
47	MP0002971_abnormal_brown_adipose	0.45537104
48	MP0003448_altered_tumor_morphology	0.44925934
49	MP0001851_eye_inflammation	0.44538171
50	MP0003329_amyloid_beta_deposits	0.44424031
51	MP0003045_fibrosis	0.43958459
52	MP0005666_abnormal_adipose_tissue	0.41140589
53	MP0004808_abnormal_hematopoietic_stem	0.40993467
54	MP0005076_abnormal_cell_differentiation	0.38329328
55	MP0010094_abnormal_chromosome_stability	0.37972471
56	MP0001533_abnormal_skeleton_physiology	0.37732656
57	MP0003172_abnormal_lysosome_physiology	0.37555630
58	MP0000569_abnormal_digit_pigmentation	0.37297443
59	MP0005023_abnormal_wound_healing	0.36889408
60	MP0008057_abnormal_DNA_replication	0.36055025
61	MP0000733_abnormal_muscle_development	0.35917488
62	MP0009115_abnormal_fat_cell	0.35740813
63	MP0004947_skin_inflammation	0.35643390
64	MP0000432_abnormal_head_morphology	0.35582698
65	MP0001958_emphysema	0.35397973
66	MP0002419_abnormal_innate_immunity	0.34735356
67	MP0003183_abnormal_peptide_metabolism	0.34084338
68	MP0003699_abnormal_female_reproductive	0.33772637
69	MP0002998_abnormal_bone_remodeling	0.32716741
70	MP0002115_abnormal_skeleton_extremities	0.32687772
71	MP0000750_abnormal_muscle_regeneration	0.32624514
72	MP0003890_abnormal_embryonic-extraembry	0.32392953
73	MP0005174_abnormal_tail_pigmentation	0.32175048
74	MP0000647_abnormal_sebaceous_gland	0.31793213
75	MP0008995_early_reproductive_senescence	0.30925615
76	MP0003633_abnormal_nervous_system	0.30358357
77	MP0002295_abnormal_pulmonary_circulatio	0.30356386
78	MP0000343_altered_response_to	0.30324279
79	MP0005636_abnormal_mineral_homeostasis	0.29903372
80	MP0005388_respiratory_system_phenotype	0.29528801
81	MP0002133_abnormal_respiratory_system	0.29528801
82	MP0004130_abnormal_muscle_cell	0.29096592
83	MP0003091_abnormal_cell_migration	0.27959918
84	MP0001119_abnormal_female_reproductive	0.27729029
85	MP0003300_gastrointestinal_ulcer	0.26857842
86	MP0005319_abnormal_enzyme/_coenzyme	0.25907528
87	MP0004858_abnormal_nervous_system	0.24868404
88	MP0006054_spinal_hemorrhage	0.24073890
89	MP0001730_embryonic_growth_arrest	0.24015734
90	MP0003786_premature_aging	0.23656758
91	MP0008007_abnormal_cellular_replicative	0.23464602
92	MP0005397_hematopoietic_system_phenotyp	0.23460226
93	MP0001545_abnormal_hematopoietic_system	0.23460226
94	MP0000015_abnormal_ear_pigmentation	0.23381787
95	MP0003795_abnormal_bone_structure	0.22901830
96	MP0003879_abnormal_hair_cell	0.21920023
97	MP0003690_abnormal_glial_cell	0.21636019
98	MP0005535_abnormal_body_temperature	0.19877779
99	MP0009250_abnormal_appendicular_skeleto	0.19814033
100	MP0002452_abnormal_antigen_presenting	0.19514352

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium morphology (HP:0005938)	8.90592983
2	Abnormal respiratory epithelium morphology (HP:0012253)	8.90592983
3	Abnormal respiratory motile cilium physiology (HP:0012261)	8.83049135
4	Rhinitis (HP:0012384)	7.78344622
5	Abnormal ciliary motility (HP:0012262)	7.02402802
6	Chronic bronchitis (HP:0004469)	6.81367703
7	Nasal polyposis (HP:0100582)	6.51849045
8	Infertility (HP:0000789)	5.73530886
9	Abnormality of the nasal mucosa (HP:0000433)	5.37103830
10	Bronchiectasis (HP:0002110)	4.36382859
11	Bronchitis (HP:0012387)	4.30816282
12	Medial flaring of the eyebrow (HP:0010747)	3.65176295
13	Nephronophthisis (HP:0000090)	3.33368645
14	Recurrent sinusitis (HP:0011108)	3.15408867
15	Recurrent otitis media (HP:0000403)	3.10307210
16	Congenital primary aphakia (HP:0007707)	3.10112457
17	Gait imbalance (HP:0002141)	3.09051632
18	Male infertility (HP:0003251)	3.03080385
19	Abnormal spermatogenesis (HP:0008669)	2.96949847
20	Nephrogenic diabetes insipidus (HP:0009806)	2.65080986
21	Recurrent bronchitis (HP:0002837)	2.63782001
22	Azoospermia (HP:0000027)	2.53361784
23	Chronic sinusitis (HP:0011109)	2.50484364
24	Abnormality of the renal medulla (HP:0100957)	2.49744269
25	Poor coordination (HP:0002370)	2.38704817
26	Tongue fasciculations (HP:0001308)	2.37925412
27	Muscle fibrillation (HP:0010546)	2.37858517
28	Impulsivity (HP:0100710)	2.36332637
29	Tubular atrophy (HP:0000092)	2.25221661
30	Aplasia/Hypoplasia of the lens (HP:0008063)	2.16688801
31	Absent frontal sinuses (HP:0002688)	2.14617297
32	Vaginal atresia (HP:0000148)	2.12913395
33	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.05024245
34	Genital tract atresia (HP:0001827)	2.04474144
35	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.8533078
36	Absent/shortened dynein arms (HP:0200106)	12.3967920
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	12.3967920
38	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.99018410
39	Tubulointerstitial nephritis (HP:0001970)	1.97598735
40	Molar tooth sign on MRI (HP:0002419)	1.95906261
41	Abnormality of midbrain morphology (HP:0002418)	1.95906261
42	Absent epiphyses (HP:0010577)	1.94464220
43	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.94464220
44	Gonadotropin excess (HP:0000837)	1.94082652
45	Spastic tetraparesis (HP:0001285)	1.91993513
46	Abnormality of saccadic eye movements (HP:0000570)	1.82725573
47	Easy fatigability (HP:0003388)	1.79078588
48	Toxemia of pregnancy (HP:0100603)	1.76053882
49	Chronic otitis media (HP:0000389)	1.75391200
50	Heterotopia (HP:0002282)	1.73231873
51	Abnormality of the neuromuscular junction (HP:0003398)	1.72910678
52	Fatigable weakness (HP:0003473)	1.72910678
53	Fibular hypoplasia (HP:0003038)	1.71095441
54	Tubulointerstitial abnormality (HP:0001969)	1.71038749
55	Cerebellar dysplasia (HP:0007033)	1.70248498
56	Type 2 muscle fiber atrophy (HP:0003554)	1.63767722
57	Abnormality of dentin (HP:0010299)	1.61751488
58	J-shaped sella turcica (HP:0002680)	1.60771341
59	Slow saccadic eye movements (HP:0000514)	1.60101692
60	Short ribs (HP:0000773)	1.58555526
61	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.57859492
62	Polygenic inheritance (HP:0010982)	1.57059972
63	Postaxial hand polydactyly (HP:0001162)	1.55505312
64	Abnormality of ocular smooth pursuit (HP:0000617)	1.54178389
65	Loss of speech (HP:0002371)	1.50502882
66	Papillary thyroid carcinoma (HP:0002895)	1.49679518
67	Retinal atrophy (HP:0001105)	1.47753052
68	Asymmetric septal hypertrophy (HP:0001670)	1.46445879
69	Impaired smooth pursuit (HP:0007772)	1.45909733
70	Difficulty climbing stairs (HP:0003551)	1.45452687
71	Stage 5 chronic kidney disease (HP:0003774)	1.45308303
72	Hyporeflexia of lower limbs (HP:0002600)	1.44287281
73	Broad foot (HP:0001769)	1.43064520
74	Microglossia (HP:0000171)	1.42437780
75	Short femoral neck (HP:0100864)	1.41854178
76	Congenital hepatic fibrosis (HP:0002612)	1.40950995
77	Cholecystitis (HP:0001082)	1.37985628
78	Abnormal gallbladder physiology (HP:0012438)	1.37985628
79	Renovascular hypertension (HP:0100817)	1.36434305
80	Tubulointerstitial fibrosis (HP:0005576)	1.35935898
81	Muscle fiber atrophy (HP:0100295)	1.35751705
82	Deformed sella turcica (HP:0002681)	1.34230575
83	Flattened epiphyses (HP:0003071)	1.34184252
84	Sensory axonal neuropathy (HP:0003390)	1.34169283
85	Renal dysplasia (HP:0000110)	1.33826689
86	Neurofibrillary tangles (HP:0002185)	1.33598797
87	Bell-shaped thorax (HP:0001591)	1.33111668
88	Supernumerary spleens (HP:0009799)	1.32045355
89	Postaxial foot polydactyly (HP:0001830)	1.30351853
90	Type II lissencephaly (HP:0007260)	1.30238730
91	Dental crowding (HP:0000678)	1.29890111
92	Weak cry (HP:0001612)	1.29420973
93	Facial cleft (HP:0002006)	1.28110438
94	Bulbar palsy (HP:0001283)	1.28021424
95	Disinhibition (HP:0000734)	1.26773018
96	Abnormality of the lower motor neuron (HP:0002366)	1.26241770
97	Decreased muscle mass (HP:0003199)	1.25362386
98	Limb ataxia (HP:0002070)	1.24512290
99	Oculomotor apraxia (HP:0000657)	1.22808306
100	Abnormality of the frontal sinuses (HP:0002687)	1.22641321

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.09763354
2	PDK4	8.09763354
3	TESK1	5.98913624
4	PDK2	5.53469240
5	PRKD3	4.35457113
6	ICK	3.57765585
7	PTK2B	2.26495331
8	WNK4	1.93171449
9	STK39	1.91841817
10	TESK2	1.70795966
11	CDK12	1.66822079
12	NEK2	1.57396192
13	PNCK	1.54401993
14	STK38	1.44584003
15	PLK4	1.40669720
16	DYRK1B	1.21840765
17	IRAK1	1.00029386
18	STK3	0.98749662
19	PDK1	0.97565172
20	RIPK4	0.97016440
21	LMTK2	0.93884490
22	RIPK1	0.91154725
23	CHEK2	0.83998588
24	TYRO3	0.82046362
25	BRSK2	0.75001123
26	DDR2	0.73025938
27	ERN1	0.69545779
28	MAP3K3	0.65324033
29	WNK1	0.64981008
30	CCNB1	0.62375695
31	CAMK1G	0.61947073
32	TTN	0.61597072
33	WEE1	0.58103385
34	PAK2	0.56717564
35	PDPK1	0.54390999
36	PAK1	0.49586974
37	TRIB3	0.48007842
38	DYRK3	0.43998270
39	MAPK15	0.43371459
40	MARK3	0.42252703
41	TBK1	0.41947829
42	MAP2K6	0.41562740
43	PASK	0.41479394
44	CHEK1	0.41255097
45	YES1	0.38737715
46	EGFR	0.38350759
47	CAMKK1	0.37190456
48	KIT	0.36293501
49	STK38L	0.33450101
50	PAK4	0.32479065
51	MTOR	0.32067037
52	TTK	0.31755288
53	PRKG2	0.31055615
54	PKN1	0.29886672
55	PDGFRB	0.27681105
56	CDK6	0.27152418
57	STK10	0.25994322
58	ATM	0.25264800
59	PLK1	0.21778384
60	EEF2K	0.19032743
61	BRSK1	0.18753090
62	CDC7	0.18495541
63	CSF1R	0.17009365
64	ZAP70	0.16886141
65	MUSK	0.16589739
66	CDK15	0.16288455
67	PLK2	0.15826892
68	PIK3CG	0.15109596
69	PTK6	0.13815420
70	ATR	0.13809254
71	NEK6	0.13406208
72	CDK18	0.12648632
73	MOS	0.12429653
74	ERBB3	0.12265204
75	CDK14	0.11845824
76	MAP3K5	0.11307426
77	PRKCG	0.11250680
78	PIM2	0.11031432
79	BMX	0.10515956
80	PRKG1	0.10354854
81	CDK11A	0.09795084
82	IRAK2	0.09505423
83	NLK	0.08463351
84	RPS6KA4	0.08391550
85	PBK	0.08240595
86	CSNK1D	0.07650598
87	SCYL2	0.06738121
88	MAPKAPK5	0.06668177
89	LATS1	0.05933021
90	MAPKAPK2	0.05856104
91	PRKACG	0.05423947
92	PRKCQ	0.05406701
93	MAP3K10	0.05202424
94	EPHB1	0.05000737
95	PRKCD	0.04639367
96	PRKAA1	0.04597263
97	CSNK2A1	0.04230203
98	MST1R	0.03985645
99	CDK4	0.03004311
100	MAP3K1	0.02851615

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	4.09955190
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	3.77198100
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.32849460
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.17173241
5	Pyruvate metabolism_Homo sapiens_hsa00620	2.93289121
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.87125313
7	Basal transcription factors_Homo sapiens_hsa03022	2.75392744
8	Pentose phosphate pathway_Homo sapiens_hsa00030	2.57306469
9	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.56763877
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.30317606
11	Propanoate metabolism_Homo sapiens_hsa00640	2.29542424
12	Glucagon signaling pathway_Homo sapiens_hsa04922	2.24493165
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.04070585
14	Glycerolipid metabolism_Homo sapiens_hsa00561	1.98176933
15	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.96810143
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89333616
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.87167993
18	PPAR signaling pathway_Homo sapiens_hsa03320	1.84902421
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.72228780
20	Oocyte meiosis_Homo sapiens_hsa04114	1.72193740
21	Mineral absorption_Homo sapiens_hsa04978	1.65689885
22	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.65535694
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.59536607
24	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.56143336
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.45045178
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38546935
27	Huntingtons disease_Homo sapiens_hsa05016	1.21962606
28	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.17319970
29	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.16544321
30	Renin-angiotensin system_Homo sapiens_hsa04614	1.13283446
31	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.11285798
32	Carbon metabolism_Homo sapiens_hsa01200	1.10593448
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.01058307
34	RNA transport_Homo sapiens_hsa03013	0.96907439
35	Amphetamine addiction_Homo sapiens_hsa05031	0.93088146
36	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.92825787
37	Phagosome_Homo sapiens_hsa04145	0.92592460
38	Legionellosis_Homo sapiens_hsa05134	0.91715940
39	Ether lipid metabolism_Homo sapiens_hsa00565	0.90659663
40	Protein digestion and absorption_Homo sapiens_hsa04974	0.90309463
41	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87946451
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85807264
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85711412
44	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.84900805
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.83950278
46	Glutathione metabolism_Homo sapiens_hsa00480	0.82475444
47	Renin secretion_Homo sapiens_hsa04924	0.79711284
48	Salmonella infection_Homo sapiens_hsa05132	0.73550459
49	Rheumatoid arthritis_Homo sapiens_hsa05323	0.73375398
50	Lysosome_Homo sapiens_hsa04142	0.71623989
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.71051949
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69035461
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.68331767
54	Purine metabolism_Homo sapiens_hsa00230	0.68200627
55	Malaria_Homo sapiens_hsa05144	0.66404642
56	Estrogen signaling pathway_Homo sapiens_hsa04915	0.65093266
57	VEGF signaling pathway_Homo sapiens_hsa04370	0.64985850
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63381364
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63210295
60	Endocytosis_Homo sapiens_hsa04144	0.61886803
61	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.61682315
62	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.61593497
63	Other glycan degradation_Homo sapiens_hsa00511	0.58669534
64	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.57473261
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.57379568
66	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.54848748
67	Osteoclast differentiation_Homo sapiens_hsa04380	0.54791040
68	ECM-receptor interaction_Homo sapiens_hsa04512	0.53346377
69	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.52853991
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52816650
71	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.52731995
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52636060
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51630044
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50602748
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48742565
76	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47985859
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46448590
78	Fatty acid degradation_Homo sapiens_hsa00071	0.46359373
79	Vibrio cholerae infection_Homo sapiens_hsa05110	0.46273413
80	Viral carcinogenesis_Homo sapiens_hsa05203	0.41330552
81	Toxoplasmosis_Homo sapiens_hsa05145	0.41210110
82	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.40923815
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.39213270
84	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.37508368
85	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.36719294
86	Bile secretion_Homo sapiens_hsa04976	0.36187136
87	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.35881463
88	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33174014
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.33084995
90	Complement and coagulation cascades_Homo sapiens_hsa04610	0.33079573
91	Long-term potentiation_Homo sapiens_hsa04720	0.31827500
92	Shigellosis_Homo sapiens_hsa05131	0.31289656
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.28895125
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.28311810
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.27903152
96	Influenza A_Homo sapiens_hsa05164	0.27235491
97	Tuberculosis_Homo sapiens_hsa05152	0.26698639
98	p53 signaling pathway_Homo sapiens_hsa04115	0.25665946
99	Metabolic pathways_Homo sapiens_hsa01100	0.24920198
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.22314318

PRSS46

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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