PRSS48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.98840145
2chemosensory behavior (GO:0007635)5.98292146
3sperm motility (GO:0030317)5.89549322
4eye photoreceptor cell differentiation (GO:0001754)5.81220885
5photoreceptor cell differentiation (GO:0046530)5.81220885
6fusion of sperm to egg plasma membrane (GO:0007342)5.31007927
7male meiosis (GO:0007140)5.06700052
8nuclear pore complex assembly (GO:0051292)5.02401000
9regulation of podosome assembly (GO:0071801)4.96511386
10sperm-egg recognition (GO:0035036)4.81154112
11binding of sperm to zona pellucida (GO:0007339)4.79545776
12hormone catabolic process (GO:0042447)4.67241371
13synaptonemal complex assembly (GO:0007130)4.58808499
14acrosome assembly (GO:0001675)4.55629276
15multicellular organism reproduction (GO:0032504)4.54538574
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.50525273
17synaptonemal complex organization (GO:0070193)4.48002730
18negative regulation of inclusion body assembly (GO:0090084)4.39523510
19negative regulation of myotube differentiation (GO:0010832)4.34897191
20regulation of hexokinase activity (GO:1903299)4.31512926
21regulation of glucokinase activity (GO:0033131)4.31512926
22spermatid development (GO:0007286)4.26813005
23O-glycan processing (GO:0016266)4.25958255
24auditory receptor cell differentiation (GO:0042491)4.22926356
25cell-cell recognition (GO:0009988)4.22148056
26fibroblast migration (GO:0010761)4.21886392
27genitalia morphogenesis (GO:0035112)4.12906461
28acrosome reaction (GO:0007340)4.12235313
29transepithelial transport (GO:0070633)4.11456506
30L-fucose catabolic process (GO:0042355)4.10840445
31fucose catabolic process (GO:0019317)4.10840445
32L-fucose metabolic process (GO:0042354)4.10840445
33positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.08608145
34intestinal cholesterol absorption (GO:0030299)4.08304036
35interleukin-6-mediated signaling pathway (GO:0070102)4.07670952
36cell wall macromolecule metabolic process (GO:0044036)4.07092813
37cell wall macromolecule catabolic process (GO:0016998)4.07092813
38motile cilium assembly (GO:0044458)4.03762310
39intestinal absorption (GO:0050892)4.01814615
40DNA methylation involved in gamete generation (GO:0043046)4.00768906
41nuclear pore organization (GO:0006999)3.95870192
42cilium or flagellum-dependent cell motility (GO:0001539)3.95738235
43receptor catabolic process (GO:0032801)3.89222121
44positive regulation of organelle assembly (GO:1902117)3.88545265
45reproduction (GO:0000003)3.87918221
46angiotensin maturation (GO:0002003)3.84698482
47mitotic sister chromatid cohesion (GO:0007064)3.83383277
48maintenance of gastrointestinal epithelium (GO:0030277)3.78509929
49pore complex assembly (GO:0046931)3.75773317
50Golgi to endosome transport (GO:0006895)3.74440033
51notochord development (GO:0030903)3.73716405
52nephron tubule morphogenesis (GO:0072078)3.71736391
53nephron epithelium morphogenesis (GO:0072088)3.71736391
54negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.70393523
55plasma membrane fusion (GO:0045026)3.64314053
56axonemal dynein complex assembly (GO:0070286)3.63706171
57intestinal epithelial cell development (GO:0060576)3.63134044
58seminiferous tubule development (GO:0072520)3.60693864
59regulation of membrane protein ectodomain proteolysis (GO:0051043)3.58972547
60regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.56744401
61cytoplasmic mRNA processing body assembly (GO:0033962)3.49967170
62COPII vesicle coating (GO:0048208)3.45071033
63regulation of somitogenesis (GO:0014807)3.45053297
64male meiosis I (GO:0007141)3.34318796
65organic cation transport (GO:0015695)3.34148056
66vocalization behavior (GO:0071625)3.33737178
67receptor recycling (GO:0001881)3.32124268
68epithelial cilium movement (GO:0003351)3.31492712
69spermatogenesis (GO:0007283)3.28923833
70male gamete generation (GO:0048232)3.28105446
71meiotic nuclear division (GO:0007126)3.21468618
72smooth muscle tissue development (GO:0048745)3.21191584
73protein O-linked glycosylation (GO:0006493)3.20238196
74regulation of bile acid biosynthetic process (GO:0070857)3.17807278
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14799095
76gamete generation (GO:0007276)3.14460469
77chromosome organization involved in meiosis (GO:0070192)3.11333794
78labyrinthine layer development (GO:0060711)3.10621774
79triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.08635440
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08084353
81drug catabolic process (GO:0042737)3.07791978
82N-terminal protein amino acid acetylation (GO:0006474)3.03555866
83fertilization (GO:0009566)3.03431880
84positive regulation of lipoprotein lipase activity (GO:0051006)3.03203607
85positive regulation of triglyceride lipase activity (GO:0061365)3.03203607
86meiotic cell cycle (GO:0051321)3.03152222
87epithelial structure maintenance (GO:0010669)3.02863733
88endothelial cell chemotaxis (GO:0035767)3.00884838
89macroautophagy (GO:0016236)2.99654595
90desmosome organization (GO:0002934)2.98908179
91protein K6-linked ubiquitination (GO:0085020)2.98579482
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98099885
93regulation of mitotic spindle checkpoint (GO:1903504)2.98099885
94regulation of Rac protein signal transduction (GO:0035020)2.96987984
95regulation of inclusion body assembly (GO:0090083)2.95436786
96protein localization to Golgi apparatus (GO:0034067)2.93059533
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92515771
98nodal signaling pathway (GO:0038092)2.91380325
99very-low-density lipoprotein particle assembly (GO:0034379)2.91105478
100urea metabolic process (GO:0019627)2.91017102
101urea cycle (GO:0000050)2.91017102
102negative regulation of dendrite morphogenesis (GO:0050774)2.90961469
103positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.89645769
104sphingomyelin metabolic process (GO:0006684)2.86893983
105positive regulation of glycolytic process (GO:0045821)2.86368537
106dorsal/ventral axis specification (GO:0009950)2.86096151
107lipoprotein metabolic process (GO:0042157)2.85495605
108sperm capacitation (GO:0048240)2.85377449
109plasma lipoprotein particle assembly (GO:0034377)2.85075527
110germ cell development (GO:0007281)2.83445937
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.82431756
112phospholipid efflux (GO:0033700)2.82256426
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81624216
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.81624216
115regulation of translation, ncRNA-mediated (GO:0045974)2.81624216
116DNA packaging (GO:0006323)2.81323580
117cellular process involved in reproduction in multicellular organism (GO:0022412)2.80797426
118collecting duct development (GO:0072044)2.79420543
119single fertilization (GO:0007338)2.79206646
120positive regulation of protein autophosphorylation (GO:0031954)2.78515424
121UDP-N-acetylglucosamine metabolic process (GO:0006047)2.75805592
122positive regulation of p38MAPK cascade (GO:1900745)2.74481948
123protein targeting to Golgi (GO:0000042)2.74030994
124regulation of triglyceride catabolic process (GO:0010896)2.74021398
125renal tubule morphogenesis (GO:0061333)2.73537988
126peptide catabolic process (GO:0043171)2.73408882
127response to inactivity (GO:0014854)2.72965033
128cilium movement (GO:0003341)2.71331935
129negative regulation of circadian rhythm (GO:0042754)2.71199410
130phosphatidylinositol 3-kinase signaling (GO:0014065)2.70953423
131microtubule severing (GO:0051013)2.70830269
132chromosome condensation (GO:0030261)2.70072330
133columnar/cuboidal epithelial cell development (GO:0002066)2.69849641
134DNA double-strand break processing (GO:0000729)2.69126012
135glucose 6-phosphate metabolic process (GO:0051156)2.69009597
136peptide hormone processing (GO:0016486)2.68548104
137cholesterol homeostasis (GO:0042632)2.68270596
138sterol homeostasis (GO:0055092)2.67976373
139gene silencing by RNA (GO:0031047)2.67109893
140Sertoli cell development (GO:0060009)2.65492321
141lactate metabolic process (GO:0006089)2.64807369
142regulation of cholesterol esterification (GO:0010872)2.64803418
143negative regulation of organelle assembly (GO:1902116)2.63953555
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63625124
145regulation of sister chromatid cohesion (GO:0007063)2.63224819
146pancreas development (GO:0031016)2.62017624
147regulation of mRNA 3-end processing (GO:0031440)2.61277906
148protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.60997767
149sulfate transmembrane transport (GO:1902358)2.60050540
150regulation of cholesterol homeostasis (GO:2000188)2.59798993
151sensory perception of smell (GO:0007608)2.59592859
152ventricular cardiac muscle cell action potential (GO:0086005)2.58694674
153fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58296692
154dendritic cell chemotaxis (GO:0002407)2.58228240
155sister chromatid cohesion (GO:0007062)2.57687928
156hair cell differentiation (GO:0035315)2.56994021
157acylglycerol homeostasis (GO:0055090)2.56786470
158triglyceride homeostasis (GO:0070328)2.56786470
159fucosylation (GO:0036065)2.55894833
160positive regulation of cell size (GO:0045793)2.55664205
161negative regulation of keratinocyte proliferation (GO:0010839)2.55553584
162positive regulation of cell cycle checkpoint (GO:1901978)2.55071566
163early endosome to late endosome transport (GO:0045022)2.54576038
164ventricular system development (GO:0021591)2.54502068
165oocyte maturation (GO:0001556)2.54432692
166photoreceptor cell maintenance (GO:0045494)2.54071497
167protein K48-linked deubiquitination (GO:0071108)2.53984983
168positive regulation of glycoprotein biosynthetic process (GO:0010560)2.53141772
169regulation of cardioblast differentiation (GO:0051890)2.53123624
170cholesterol efflux (GO:0033344)2.52635877
171phasic smooth muscle contraction (GO:0014821)2.52302926
172nitrogen cycle metabolic process (GO:0071941)2.52105105
173endocardial cushion morphogenesis (GO:0003203)2.51823648
174establishment of protein localization to Golgi (GO:0072600)2.51417496
175uterus development (GO:0060065)2.51276908
176protein-lipid complex assembly (GO:0065005)2.51193082
177fructose metabolic process (GO:0006000)2.51036666
178regulation of Golgi to plasma membrane protein transport (GO:0042996)2.50911748
179embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49707769
180RNA localization (GO:0006403)2.49358397
181secondary heart field specification (GO:0003139)2.48923466
182heart field specification (GO:0003128)2.48923466
183multicellular organismal reproductive process (GO:0048609)2.48606727
184NLS-bearing protein import into nucleus (GO:0006607)2.48549653
185cysteine metabolic process (GO:0006534)2.48335166
186meiosis I (GO:0007127)2.48043207
187G-protein coupled receptor internalization (GO:0002031)2.46619795
188muscle atrophy (GO:0014889)2.44934454

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.18775778
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.00536342
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.95413918
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.39333268
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.96764706
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57837431
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.51251864
8GBX2_23144817_ChIP-Seq_PC3_Human2.51196723
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.43432197
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34396737
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32656918
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.13500273
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02257533
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.99187990
15RXR_22158963_ChIP-Seq_LIVER_Mouse1.98132236
16NR3C1_21868756_ChIP-Seq_MCF10A_Human1.98048847
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.96852288
18ER_23166858_ChIP-Seq_MCF-7_Human1.86430710
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78201945
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.76653272
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73086779
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69390208
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69144873
24CJUN_26792858_Chip-Seq_BT549_Human1.69017060
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.68019936
26* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63695447
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60833485
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59637677
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.58498445
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.56284880
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.56284880
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56236347
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56218224
34AR_21909140_ChIP-Seq_LNCAP_Human1.55762258
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.55467031
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.54279073
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53018898
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.51452406
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51418574
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50445516
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.50356938
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.49179055
43EWS_26573619_Chip-Seq_HEK293_Human1.48088593
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47161217
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46297506
46TAF15_26573619_Chip-Seq_HEK293_Human1.46121279
47GATA4_25053715_ChIP-Seq_YYC3_Human1.45340674
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42297166
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42283729
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41836629
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41821462
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.39010975
53P300_19829295_ChIP-Seq_ESCs_Human1.38056896
54FUS_26573619_Chip-Seq_HEK293_Human1.37567961
55VDR_22108803_ChIP-Seq_LS180_Human1.36067726
56CDX2_22108803_ChIP-Seq_LS180_Human1.35875889
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35347633
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35221283
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35221283
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33587407
61TP53_16413492_ChIP-PET_HCT116_Human1.32356689
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31550364
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.31465610
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30813209
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29879631
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28270983
67FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.28248956
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27071466
69AHR_22903824_ChIP-Seq_MCF-7_Human1.27030103
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26879967
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26128870
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25226434
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22820445
74GATA6_25053715_ChIP-Seq_YYC3_Human1.22439952
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22189618
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21803722
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21002832
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19775585
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19608871
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19537447
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19416570
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.17771045
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.17533970
84STAT1_17558387_ChIP-Seq_HELA_Human1.16984313
85AR_25329375_ChIP-Seq_VCAP_Human1.16767712
86STAT3_23295773_ChIP-Seq_U87_Human1.16708396
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16108117
88RUNX2_22187159_ChIP-Seq_PCA_Human1.15920086
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.15683221
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15566590
91RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15522889
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15506776
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.15238553
94RXR_22108803_ChIP-Seq_LS180_Human1.15097807
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.14953000
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14520792
97* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14459543
98HNF4A_19822575_ChIP-Seq_HepG2_Human1.14381225
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.13381717
100CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12677769
101* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12105089
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11780298
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11571685
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11429358
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11189029
106OCT4_18555785_Chip-Seq_ESCs_Mouse1.10628855
107PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10302519
108GF1B_26923725_Chip-Seq_HPCs_Mouse1.10095411
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09900063
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09556555
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08009342
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07379593
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07321895
114TCF4_23295773_ChIP-Seq_U87_Human1.06785781
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.06783159
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06672183
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06321547
118BCAT_22108803_ChIP-Seq_LS180_Human1.06245501
119SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05626757
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05406450
121TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04994548
122AR_21572438_ChIP-Seq_LNCaP_Human1.04401932
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03362515
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03184108
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03158361
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.01046637
127KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98921615
128ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98464405
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97561715
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97403081
131* SMAD4_21799915_ChIP-Seq_A2780_Human0.97248562
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.97061090
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.96446717
134TP63_23658742_ChIP-Seq_EP156T_Human0.96414761
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96391770
136GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.96376373
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96298802
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.96259193
139CBP_20019798_ChIP-Seq_JUKART_Human0.95761231
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95761231
141STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95446184
142TCF4_22108803_ChIP-Seq_LS180_Human0.95415054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.22423508
2MP0002139_abnormal_hepatobiliary_system4.45860759
3MP0005360_urolithiasis4.10359334
4MP0004264_abnormal_extraembryonic_tissu3.79197212
5MP0001485_abnormal_pinna_reflex2.79399318
6MP0008877_abnormal_DNA_methylation2.77711566
7MP0005365_abnormal_bile_salt2.57362555
8MP0003252_abnormal_bile_duct2.55344259
9MP0003195_calcinosis2.55308724
10MP0005085_abnormal_gallbladder_physiolo2.53993679
11MP0001666_abnormal_nutrient_absorption2.52452278
12MP0003941_abnormal_skin_development2.37640217
13MP0001929_abnormal_gametogenesis2.29176718
14MP0003646_muscle_fatigue2.24093070
15MP0004084_abnormal_cardiac_muscle2.23835885
16MP0003943_abnormal_hepatobiliary_system2.22671890
17MP0000566_synostosis2.19717082
18MP0000579_abnormal_nail_morphology2.11406550
19MP0003698_abnormal_male_reproductive2.00505668
20MP0008775_abnormal_heart_ventricle1.95222185
21MP0005670_abnormal_white_adipose1.89906486
22MP0010329_abnormal_lipoprotein_level1.83979564
23MP0000462_abnormal_digestive_system1.82543294
24MP0002822_catalepsy1.81980032
25MP0008875_abnormal_xenobiotic_pharmacok1.81392428
26MP0003123_paternal_imprinting1.75471778
27MP0002653_abnormal_ependyma_morphology1.75120068
28MP0003315_abnormal_perineum_morphology1.74330946
29MP0004036_abnormal_muscle_relaxation1.70323605
30MP0010678_abnormal_skin_adnexa1.69586647
31MP0002160_abnormal_reproductive_system1.68836801
32MP0005377_hearing/vestibular/ear_phenot1.68164887
33MP0003878_abnormal_ear_physiology1.68164887
34MP0003718_maternal_effect1.66010450
35MP0000383_abnormal_hair_follicle1.63932637
36MP0002210_abnormal_sex_determination1.57462415
37MP0005551_abnormal_eye_electrophysiolog1.56727555
38MP0002098_abnormal_vibrissa_morphology1.55935609
39MP0005076_abnormal_cell_differentiation1.54918118
40MP0005083_abnormal_biliary_tract1.53700407
41MP0010234_abnormal_vibrissa_follicle1.53319754
42MP0002254_reproductive_system_inflammat1.52217839
43MP0002796_impaired_skin_barrier1.50451338
44MP0002108_abnormal_muscle_morphology1.48780219
45MP0003868_abnormal_feces_composition1.46742772
46MP0001756_abnormal_urination1.43880411
47MP0003937_abnormal_limbs/digits/tail_de1.43244931
48MP0000427_abnormal_hair_cycle1.43201389
49MP0010368_abnormal_lymphatic_system1.42662198
50MP0004019_abnormal_vitamin_homeostasis1.40029728
51MP0005257_abnormal_intraocular_pressure1.39826359
52MP0008004_abnormal_stomach_pH1.39189289
53MP0001145_abnormal_male_reproductive1.36839602
54MP0005646_abnormal_pituitary_gland1.36017636
55MP0003866_abnormal_defecation1.35923634
56MP0000653_abnormal_sex_gland1.33695123
57MP0000470_abnormal_stomach_morphology1.31531975
58MP0010307_abnormal_tumor_latency1.31111469
59MP0000538_abnormal_urinary_bladder1.29505425
60MP0001293_anophthalmia1.27021117
61MP0002161_abnormal_fertility/fecundity1.26586042
62MP0001664_abnormal_digestion1.25747523
63MP0003950_abnormal_plasma_membrane1.23728038
64MP0003787_abnormal_imprinting1.23428950
65MP0003806_abnormal_nucleotide_metabolis1.22769679
66MP0003786_premature_aging1.21748339
67MP0004043_abnormal_pH_regulation1.19922376
68MP0000569_abnormal_digit_pigmentation1.19730787
69MP0009384_cardiac_valve_regurgitation1.19470122
70MP0000749_muscle_degeneration1.17544083
71MP0008995_early_reproductive_senescence1.16330507
72MP0009697_abnormal_copulation1.16170707
73MP0003890_abnormal_embryonic-extraembry1.16082361
74MP0004145_abnormal_muscle_electrophysio1.14364769
75MP0009053_abnormal_anal_canal1.14353746
76MP0008057_abnormal_DNA_replication1.14164316
77MP0009840_abnormal_foam_cell1.13704899
78MP0005395_other_phenotype1.11955944
79MP0006138_congestive_heart_failure1.11649239
80MP0000762_abnormal_tongue_morphology1.10427544
81MP0002127_abnormal_cardiovascular_syste1.08574275
82MP0005023_abnormal_wound_healing1.08454730
83MP0008058_abnormal_DNA_repair1.08371522
84MP0003705_abnormal_hypodermis_morpholog1.08082602
85MP0003045_fibrosis1.05440394
86MP0001299_abnormal_eye_distance/1.04794536
87MP0005248_abnormal_Harderian_gland1.04091463
88MP0002090_abnormal_vision1.03740620
89MP0002282_abnormal_trachea_morphology1.01321902
90MP0008872_abnormal_physiological_respon1.01204043
91MP0010352_gastrointestinal_tract_polyps1.00591941
92MP0000647_abnormal_sebaceous_gland1.00053802
93MP0005220_abnormal_exocrine_pancreas0.99780415
94MP0000432_abnormal_head_morphology0.96750896
95MP0005187_abnormal_penis_morphology0.96663126
96MP0003693_abnormal_embryo_hatching0.96018242
97MP0006072_abnormal_retinal_apoptosis0.95222784
98MP0000733_abnormal_muscle_development0.94787613
99MP0001661_extended_life_span0.93941153
100MP0003121_genomic_imprinting0.93633480
101MP0001501_abnormal_sleep_pattern0.92711212
102MP0003755_abnormal_palate_morphology0.92551784
103MP0002938_white_spotting0.91172690
104MP0009703_decreased_birth_body0.90791317
105MP0005253_abnormal_eye_physiology0.89588032
106MP0001873_stomach_inflammation0.88364575
107MP0001765_abnormal_ion_homeostasis0.87700977
108MP0003119_abnormal_digestive_system0.86851993
109MP0004085_abnormal_heartbeat0.86791054
110MP0002092_abnormal_eye_morphology0.86596538
111MP0001270_distended_abdomen0.85706718
112MP0004381_abnormal_hair_follicle0.84721667
113MP0003385_abnormal_body_wall0.84245568
114MP0001730_embryonic_growth_arrest0.84045122
115MP0004484_altered_response_of0.83284853
116MP0009780_abnormal_chondrocyte_physiolo0.82985314
117MP0003283_abnormal_digestive_organ0.82539739
118MP0004197_abnormal_fetal_growth/weight/0.82041449
119MP0003935_abnormal_craniofacial_develop0.81972059
120MP0000163_abnormal_cartilage_morphology0.81874633
121MP0000377_abnormal_hair_follicle0.81563009
122MP0002233_abnormal_nose_morphology0.81359614
123MP0002118_abnormal_lipid_homeostasis0.81133705
124MP0002060_abnormal_skin_morphology0.80358232
125MP0000230_abnormal_systemic_arterial0.80064102
126MP0005408_hypopigmentation0.79914043
127MP0000609_abnormal_liver_physiology0.79861497
128MP0004272_abnormal_basement_membrane0.79823085
129MP0002084_abnormal_developmental_patter0.79613479
130MP0001216_abnormal_epidermal_layer0.79464854
131MP0004957_abnormal_blastocyst_morpholog0.78557028
132MP0004215_abnormal_myocardial_fiber0.77816313
133MP0002896_abnormal_bone_mineralization0.77747352
134MP0008961_abnormal_basal_metabolism0.77640841
135MP0005275_abnormal_skin_tensile0.77492891
136MP0004147_increased_porphyrin_level0.76869761
137MP0010630_abnormal_cardiac_muscle0.76266055
138MP0009672_abnormal_birth_weight0.75832205
139MP0000534_abnormal_ureter_morphology0.75621595
140MP0002269_muscular_atrophy0.73418590
141MP0010094_abnormal_chromosome_stability0.73177711
142MP0002697_abnormal_eye_size0.72879859
143MP0002109_abnormal_limb_morphology0.72831399
144MP0003300_gastrointestinal_ulcer0.72656897
145MP0002111_abnormal_tail_morphology0.72326128
146MP0000613_abnormal_salivary_gland0.72139508
147MP0002277_abnormal_respiratory_mucosa0.72079877
148MP0003183_abnormal_peptide_metabolism0.72073619
149MP0002102_abnormal_ear_morphology0.71819768
150MP0003115_abnormal_respiratory_system0.71680311
151MP0010030_abnormal_orbit_morphology0.71334478
152MP0002168_other_aberrant_phenotype0.71177631
153MP0000751_myopathy0.70878213
154MP0003111_abnormal_nucleus_morphology0.70814553
155MP0001672_abnormal_embryogenesis/_devel0.70745285
156MP0005380_embryogenesis_phenotype0.70745285
157MP0003699_abnormal_female_reproductive0.70589459
158MP0003936_abnormal_reproductive_system0.70528470
159MP0002085_abnormal_embryonic_tissue0.69937036
160MP0000537_abnormal_urethra_morphology0.69733316
161MP0002751_abnormal_autonomic_nervous0.67781074
162MP0001486_abnormal_startle_reflex0.65815310
163MP0008438_abnormal_cutaneous_collagen0.63462155

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal septum (HP:0000419)5.65173974
2Abnormality of the fingertips (HP:0001211)5.49944850
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.47767747
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.85371983
5Absent/shortened dynein arms (HP:0200106)4.85371983
6Right ventricular cardiomyopathy (HP:0011663)4.17970702
7Chronic bronchitis (HP:0004469)4.14188588
8Hyperactive renin-angiotensin system (HP:0000841)4.07099597
9Tetraparesis (HP:0002273)4.05604080
10Autoimmune hemolytic anemia (HP:0001890)3.63131808
11Hypobetalipoproteinemia (HP:0003563)3.54811325
12Irregular epiphyses (HP:0010582)3.41036568
13Hypoplastic ischia (HP:0003175)3.40493421
14Abnormal respiratory motile cilium physiology (HP:0012261)3.36674452
15Broad-based gait (HP:0002136)3.28178652
16Vitreoretinal degeneration (HP:0000655)3.23835246
17IgM deficiency (HP:0002850)3.22601674
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19898982
19Depressed nasal tip (HP:0000437)3.19746263
20Abnormality of the ischium (HP:0003174)3.14274650
21Abnormality of the preputium (HP:0100587)3.11807360
22Genetic anticipation (HP:0003743)3.10944651
23Abnormality of chloride homeostasis (HP:0011422)3.09983447
24Epiphyseal dysplasia (HP:0002656)3.09515141
25Flat capital femoral epiphysis (HP:0003370)3.04801857
26Widely patent fontanelles and sutures (HP:0004492)3.04177790
27Small epiphyses (HP:0010585)2.93322669
28Heterotopia (HP:0002282)2.91219300
29Chromsome breakage (HP:0040012)2.90171218
30Infertility (HP:0000789)2.88510463
31Abnormal hair whorl (HP:0010721)2.87796879
32Conjugated hyperbilirubinemia (HP:0002908)2.86646852
33Abnormality of renin-angiotensin system (HP:0000847)2.82571253
34Acanthocytosis (HP:0001927)2.82268991
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.71808021
36Hypoplastic labia majora (HP:0000059)2.71675874
37Increased circulating renin level (HP:0000848)2.64946615
38Impulsivity (HP:0100710)2.64282498
39Intrahepatic cholestasis (HP:0001406)2.62241460
40Hypolipoproteinemia (HP:0010981)2.61980415
41Rhinitis (HP:0012384)2.61757340
42Abnormality of the distal phalanx of the thumb (HP:0009617)2.60051089
43Potter facies (HP:0002009)2.57769809
44Facial shape deformation (HP:0011334)2.57769809
45Cupped ribs (HP:0000887)2.55966659
46Gaze-evoked nystagmus (HP:0000640)2.55528356
47Hyperinsulinemic hypoglycemia (HP:0000825)2.54572970
48Abnormality of incisor morphology (HP:0011063)2.54320499
49Decreased circulating renin level (HP:0003351)2.53071745
50Abnormal respiratory epithelium morphology (HP:0012253)2.52273562
51Abnormal respiratory motile cilium morphology (HP:0005938)2.52273562
52Abnormal biliary tract morphology (HP:0012440)2.51320224
53Hepatoblastoma (HP:0002884)2.50753624
54Aortic dissection (HP:0002647)2.41782899
55Cone-rod dystrophy (HP:0000548)2.39496933
56Chronic diarrhea (HP:0002028)2.38509833
57Aortic aneurysm (HP:0004942)2.37796368
58Abnormality of the labia majora (HP:0012881)2.36118318
59Hyporeflexia of lower limbs (HP:0002600)2.36017420
60Intestinal atresia (HP:0011100)2.35786379
61Pigmentary retinal degeneration (HP:0001146)2.33828575
62Abnormal ciliary motility (HP:0012262)2.31624563
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.31345205
64Delayed epiphyseal ossification (HP:0002663)2.30320440
65Duplicated collecting system (HP:0000081)2.29536343
66Malnutrition (HP:0004395)2.29500209
67Male infertility (HP:0003251)2.29161127
68Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.28629160
69Abnormality of femoral epiphyses (HP:0006499)2.28629160
70Hypoplastic iliac wings (HP:0002866)2.28023519
71Flat acetabular roof (HP:0003180)2.27561712
72Abnormality of the proximal phalanges of the hand (HP:0009834)2.27040723
73Limited elbow extension (HP:0001377)2.25869362
74Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.24030936
75Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.22372584
76Congenital, generalized hypertrichosis (HP:0004540)2.21398675
77Tubulointerstitial nephritis (HP:0001970)2.20914482
78Volvulus (HP:0002580)2.18253613
79Arthropathy (HP:0003040)2.17561971
80Abnormality of the epiphysis of the femoral head (HP:0010574)2.16894952
81Hyperglycemia (HP:0003074)2.16839006
82Adrenal hypoplasia (HP:0000835)2.16401642
83Abnormality of the 1st metacarpal (HP:0010009)2.12875317
84Cerebellar dysplasia (HP:0007033)2.12789925
85Chronic hepatic failure (HP:0100626)2.12316886
86Narrow palate (HP:0000189)2.11642673
87Hyperaldosteronism (HP:0000859)2.10868680
88Absent epiphyses (HP:0010577)2.10242512
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.10242512
90Lip pit (HP:0100267)2.06494191
91Abnormality of the lower motor neuron (HP:0002366)2.06312455
92Severe Myopia (HP:0011003)2.06266383
93Abnormality of the epiphyses of the hand (HP:0005924)2.04405961
94Poikiloderma (HP:0001029)2.03470095
95Glossoptosis (HP:0000162)2.03184892
96Alopecia of scalp (HP:0002293)2.02549030
97Ureteral duplication (HP:0000073)2.02394954
98Supernumerary ribs (HP:0005815)2.01032828
99Hyperglycinemia (HP:0002154)2.00824150
100Abnormality of the ileum (HP:0001549)1.99897614
101IgA deficiency (HP:0002720)1.99174280
102Fibular hypoplasia (HP:0003038)1.98777994
103Wide cranial sutures (HP:0010537)1.97890737
104Alacrima (HP:0000522)1.97493210
105Chorioretinal atrophy (HP:0000533)1.96719641
106Midline defect of the nose (HP:0004122)1.96213662
107Decreased muscle mass (HP:0003199)1.96077345
108Long eyelashes (HP:0000527)1.95907924
109Abnormality of the femoral head (HP:0003368)1.94568075
110Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.94448815
111Bilateral sensorineural hearing impairment (HP:0008619)1.94187587
112Meckel diverticulum (HP:0002245)1.94029926
113Abnormality of the renal collecting system (HP:0004742)1.93902269
114Abnormality of the astrocytes (HP:0100707)1.93611456
115Astrocytoma (HP:0009592)1.93611456
116Ileus (HP:0002595)1.92792071
117Wrist flexion contracture (HP:0001239)1.92451827
118Hypsarrhythmia (HP:0002521)1.89693616
119Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89326728
120Xanthomatosis (HP:0000991)1.88819220
121Glioma (HP:0009733)1.88609248
122EEG with generalized epileptiform discharges (HP:0011198)1.88403580
123Colitis (HP:0002583)1.88354517
124Epidermoid cyst (HP:0200040)1.87015162
125Abnormality of potassium homeostasis (HP:0011042)1.86223622
126Milia (HP:0001056)1.85743815
127Progressive cerebellar ataxia (HP:0002073)1.85726646
128Ulnar bowing (HP:0003031)1.85287713
129Abnormality of the parathyroid morphology (HP:0011766)1.85220083
130Acute myeloid leukemia (HP:0004808)1.84224520
131Abnormality of the pubic bones (HP:0003172)1.84087839
132Vascular calcification (HP:0004934)1.82841546
133Short phalanx of the thumb (HP:0009660)1.82543053
134Tubular atrophy (HP:0000092)1.82539610
135Abnormal tarsal ossification (HP:0008369)1.82146795
136Poor eye contact (HP:0000817)1.80346924
137Breast carcinoma (HP:0003002)1.80258428
138Abnormal biliary tract physiology (HP:0012439)1.79760339
139Bile duct proliferation (HP:0001408)1.79760339
140Abnormality of the carotid arteries (HP:0005344)1.78934153
141Sensory axonal neuropathy (HP:0003390)1.78850790
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78540435
143Neoplasm of the oral cavity (HP:0100649)1.78051202
144Abnormal hand bone ossification (HP:0010660)1.77405411
145Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.77177656
146Villous atrophy (HP:0011473)1.77063269
147Abnormality of small intestinal villus morphology (HP:0011472)1.77063269
148Hypoalphalipoproteinemia (HP:0003233)1.76356189
149Rhabdomyosarcoma (HP:0002859)1.76183343
150True hermaphroditism (HP:0010459)1.75606289
151Supernumerary bones of the axial skeleton (HP:0009144)1.75434672
152Fat malabsorption (HP:0002630)1.74931983
153Keratoconus (HP:0000563)1.74519302
154Increased corneal curvature (HP:0100692)1.74519302
155Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74302726
156Epileptiform EEG discharges (HP:0011182)1.73848381
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73361647
158Protuberant abdomen (HP:0001538)1.72386295
159Abnormality of chromosome stability (HP:0003220)1.72381591
160Neonatal short-limb short stature (HP:0008921)1.72318832
161Abnormality of the labia minora (HP:0012880)1.72296899
162Sparse lateral eyebrow (HP:0005338)1.72272113
163Neoplasm of striated muscle (HP:0009728)1.72129497
164Prostate neoplasm (HP:0100787)1.71907618
165Ectopic kidney (HP:0000086)1.71870043
166Clubbing of toes (HP:0100760)1.71812154
167Limited hip movement (HP:0008800)1.71660387
168Hypoplasia of dental enamel (HP:0006297)1.71218864
169Microglossia (HP:0000171)1.70812157
170Hyperkalemia (HP:0002153)1.70555535
171Biliary tract neoplasm (HP:0100574)1.70459656
172Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70406440
173Abnormal pancreas size (HP:0012094)1.69902508
174Progressive sensorineural hearing impairment (HP:0000408)1.69503609
175Poor coordination (HP:0002370)1.69502132
176Cardiovascular calcification (HP:0011915)1.68354788
177Genu varum (HP:0002970)1.67976986
178Bronchiectasis (HP:0002110)1.67800621
179Vertebral clefting (HP:0008428)1.66994242
180Enlarged kidneys (HP:0000105)1.66422397
181Insulin-resistant diabetes mellitus (HP:0000831)1.66050264
182Short middle phalanx of finger (HP:0005819)1.66043752
183Hypoglycemic coma (HP:0001325)1.65991919
184Shawl scrotum (HP:0000049)1.65377300
185Hypochromic microcytic anemia (HP:0004840)1.64993889
186Hypoglycemic seizures (HP:0002173)1.64789036
187Thoracolumbar scoliosis (HP:0002944)1.64490901
188Abnormality of sulfur amino acid metabolism (HP:0004339)1.64319884
189Urethral obstruction (HP:0000796)1.63316388
190Abnormal spermatogenesis (HP:0008669)1.63139468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.27526477
2EPHA24.00566337
3CDK123.68613864
4PDK33.54657116
5PDK43.54657116
6ICK2.91334477
7OXSR12.87508273
8BRSK22.62546924
9TTK2.55852740
10PRKD32.41600369
11PBK2.35685868
12PDK22.25652598
13STK32.25043494
14EIF2AK32.22161367
15MKNK22.18479086
16TESK12.12160198
17MAPK152.09778768
18STK38L2.09044599
19AKT32.06967980
20SIK11.77051281
21INSRR1.73372450
22TAOK31.66653820
23FRK1.66060432
24ERBB41.62350522
25WNK41.59268068
26STK391.55566038
27MST1R1.48461403
28MET1.46139051
29TRIM281.42747772
30ERN11.35383166
31BRD41.32078225
32NEK21.29554867
33CDC71.18944521
34SCYL21.17920212
35TYRO31.17490524
36MST41.16700543
37MAP3K31.15842893
38CHEK21.14214432
39NUAK11.14186600
40MKNK11.11070701
41PRKG21.06005770
42ZAK1.05383909
43MTOR1.04412195
44WNK11.03979683
45PAK31.02197736
46DYRK1B0.94808740
47ACVR1B0.94634368
48MARK20.92686203
49FGFR20.91281646
50STK100.89561556
51MAP3K40.86428087
52DDR20.85254075
53ERBB20.82562144
54BCR0.82396373
55TRPM70.79461275
56MAPKAPK30.78502160
57PLK10.75835898
58BRAF0.75002257
59CDK70.74486889
60PTK20.72943705
61NLK0.72444731
62BLK0.71944799
63OBSCN0.71872144
64MYLK0.70987078
65LMTK20.70084940
66ATM0.69467816
67EPHB10.68966936
68BRSK10.68267037
69EPHA30.67843725
70PRKAA10.67829167
71CHEK10.67542564
72LATS20.67508746
73TAOK10.67054709
74PRKAA20.66293520
75PHKG10.65160215
76PHKG20.65160215
77PRKCI0.64914843
78STK380.64681008
79SIK30.64108767
80NME10.63389755
81BMPR1B0.63052059
82MAP3K100.63010319
83CASK0.59859875
84AURKB0.58245406
85CAMK1D0.57670499
86PRKCE0.57302007
87PTK2B0.56113289
88FGFR10.56062371
89PLK30.55884171
90RIPK10.54736762
91PTK60.54421008
92DMPK0.53261858
93PASK0.52244875
94GSK3A0.51954013
95MELK0.49813005
96MAP3K120.49351619
97EEF2K0.48179211
98SGK30.47305194
99SGK20.47130314
100PKN20.46651090
101CSNK1A1L0.46401109
102CSNK1D0.46343314
103PIK3CA0.45434804
104SRPK10.44894056
105NEK60.44449314
106TNIK0.42988516
107ATR0.42873445
108NTRK10.42396656
109STK240.42020166
110MAP2K10.41943114
111MAP3K70.41770048
112FER0.40974824
113CSNK1E0.40942238
114IRAK10.40851877
115PDGFRB0.39740134
116WEE10.38696937
117CAMK40.38689499
118CDK10.38223845
119GRK10.38151263
120EGFR0.37535391
121CDK30.37015984
122CDK20.36949188
123PLK40.36687966
124ROCK10.35283932
125PNCK0.34811842
126SGK10.34196269
127EPHA40.34004096
128EIF2AK20.33489073
129MAPKAPK50.32521161
130GSK3B0.32252833
131MAPK140.32143853
132TTN0.31955783
133CAMK1G0.31011841
134CHUK0.30375294
135FGFR40.30195904
136MAPK100.29512444
137MAP3K10.29117804
138GRK60.29044830
139BMX0.28978602
140MAPK110.27999533
141AKT10.24112542
142CSNK1A10.23996294
143CAMK2D0.23022173
144RPS6KA30.21939195
145SGK2230.20686426
146SGK4940.20686426
147MAP2K60.20203990

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.90351963
2Fat digestion and absorption_Homo sapiens_hsa049753.48230775
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.41906358
4Vitamin digestion and absorption_Homo sapiens_hsa049773.11121798
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.07305016
6Vitamin B6 metabolism_Homo sapiens_hsa007502.60868318
7Renin-angiotensin system_Homo sapiens_hsa046142.57488170
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.38781707
9Nitrogen metabolism_Homo sapiens_hsa009102.31288262
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02748246
11Galactose metabolism_Homo sapiens_hsa000521.90610976
12Selenocompound metabolism_Homo sapiens_hsa004501.88905018
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.79973624
14Starch and sucrose metabolism_Homo sapiens_hsa005001.79539216
15Linoleic acid metabolism_Homo sapiens_hsa005911.76916481
16Folate biosynthesis_Homo sapiens_hsa007901.75656979
17Fatty acid biosynthesis_Homo sapiens_hsa000611.68371419
18PPAR signaling pathway_Homo sapiens_hsa033201.67375433
19Lysine degradation_Homo sapiens_hsa003101.62162144
20Sphingolipid metabolism_Homo sapiens_hsa006001.60313780
21Mineral absorption_Homo sapiens_hsa049781.60165814
22Protein digestion and absorption_Homo sapiens_hsa049741.52244668
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42056463
24Fatty acid degradation_Homo sapiens_hsa000711.37540792
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37287145
26Fructose and mannose metabolism_Homo sapiens_hsa000511.36192238
27Inositol phosphate metabolism_Homo sapiens_hsa005621.35075286
28Tryptophan metabolism_Homo sapiens_hsa003801.34868618
29Homologous recombination_Homo sapiens_hsa034401.30710368
30Ether lipid metabolism_Homo sapiens_hsa005651.30284532
31Caffeine metabolism_Homo sapiens_hsa002321.28562615
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28090742
33Pyruvate metabolism_Homo sapiens_hsa006201.26826725
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.25376044
35Arginine biosynthesis_Homo sapiens_hsa002201.24659387
36Salivary secretion_Homo sapiens_hsa049701.24358093
37Histidine metabolism_Homo sapiens_hsa003401.24308706
38Bile secretion_Homo sapiens_hsa049761.23143140
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20573998
40Sulfur metabolism_Homo sapiens_hsa009201.19642634
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18173184
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.17363895
43Glucagon signaling pathway_Homo sapiens_hsa049221.13726459
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13207176
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12588986
46ABC transporters_Homo sapiens_hsa020101.11542325
47Steroid biosynthesis_Homo sapiens_hsa001001.08652864
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08631352
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08166703
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05549732
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04036617
52Basal cell carcinoma_Homo sapiens_hsa052171.03101002
53Fatty acid metabolism_Homo sapiens_hsa012121.02014573
54RNA polymerase_Homo sapiens_hsa030201.01956448
55Mismatch repair_Homo sapiens_hsa034301.01729513
56Glycerolipid metabolism_Homo sapiens_hsa005611.01678578
57Adherens junction_Homo sapiens_hsa045201.01610872
58Dorso-ventral axis formation_Homo sapiens_hsa043201.00970399
59Non-homologous end-joining_Homo sapiens_hsa034501.00494926
60Hedgehog signaling pathway_Homo sapiens_hsa043400.98750251
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98086966
62Gastric acid secretion_Homo sapiens_hsa049710.97904537
63Pancreatic secretion_Homo sapiens_hsa049720.97325706
64Peroxisome_Homo sapiens_hsa041460.97068313
65Insulin secretion_Homo sapiens_hsa049110.96104476
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.95097264
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94710218
68Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91988142
69Hippo signaling pathway_Homo sapiens_hsa043900.91950154
70Thyroid hormone synthesis_Homo sapiens_hsa049180.89189930
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.88501416
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87938807
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87567244
74Propanoate metabolism_Homo sapiens_hsa006400.86590172
75Tight junction_Homo sapiens_hsa045300.86000428
76Retinol metabolism_Homo sapiens_hsa008300.85944352
77Complement and coagulation cascades_Homo sapiens_hsa046100.79712527
78ECM-receptor interaction_Homo sapiens_hsa045120.79341284
79Circadian rhythm_Homo sapiens_hsa047100.79209823
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79157613
81Chemical carcinogenesis_Homo sapiens_hsa052040.77607095
82Taste transduction_Homo sapiens_hsa047420.75714709
83Olfactory transduction_Homo sapiens_hsa047400.75184285
84Pentose phosphate pathway_Homo sapiens_hsa000300.73388062
85One carbon pool by folate_Homo sapiens_hsa006700.72712761
86Glutathione metabolism_Homo sapiens_hsa004800.72689736
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70003615
88Phenylalanine metabolism_Homo sapiens_hsa003600.69990351
89Arachidonic acid metabolism_Homo sapiens_hsa005900.69243206
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68931283
91Proteoglycans in cancer_Homo sapiens_hsa052050.68047333
92Tyrosine metabolism_Homo sapiens_hsa003500.66286708
93Prostate cancer_Homo sapiens_hsa052150.66247681
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64787775
95FoxO signaling pathway_Homo sapiens_hsa040680.64133119
96Choline metabolism in cancer_Homo sapiens_hsa052310.63552912
97Cell cycle_Homo sapiens_hsa041100.62972260
98RNA degradation_Homo sapiens_hsa030180.62968825
99Calcium signaling pathway_Homo sapiens_hsa040200.60439885
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.59166413
101TGF-beta signaling pathway_Homo sapiens_hsa043500.59106623
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59086106
103Ovarian steroidogenesis_Homo sapiens_hsa049130.59034596
104Notch signaling pathway_Homo sapiens_hsa043300.57138148
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55780644
106mRNA surveillance pathway_Homo sapiens_hsa030150.55625414
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54658129
108RNA transport_Homo sapiens_hsa030130.54651613
109Dilated cardiomyopathy_Homo sapiens_hsa054140.54434292
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53975717
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53747964
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53240847
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52371886
114Fanconi anemia pathway_Homo sapiens_hsa034600.51471330
115AMPK signaling pathway_Homo sapiens_hsa041520.50406614
116Glutamatergic synapse_Homo sapiens_hsa047240.50271427
117Phototransduction_Homo sapiens_hsa047440.50150149
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49868154
119p53 signaling pathway_Homo sapiens_hsa041150.49866183
120Carbon metabolism_Homo sapiens_hsa012000.49572952
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47014758
122Basal transcription factors_Homo sapiens_hsa030220.46967109
123Circadian entrainment_Homo sapiens_hsa047130.44601481
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.43129769
125Arginine and proline metabolism_Homo sapiens_hsa003300.42882286
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.42586781
127Insulin resistance_Homo sapiens_hsa049310.40911095
128Oocyte meiosis_Homo sapiens_hsa041140.40876655
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39751356
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39055137
131MicroRNAs in cancer_Homo sapiens_hsa052060.36838525
132Type II diabetes mellitus_Homo sapiens_hsa049300.36631276
133Wnt signaling pathway_Homo sapiens_hsa043100.35375735
134Butanoate metabolism_Homo sapiens_hsa006500.34506458
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33646959
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32781261
137Metabolic pathways_Homo sapiens_hsa011000.32542000
138Fatty acid elongation_Homo sapiens_hsa000620.31620580

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