PRSS53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)8.17205607
2endocrine pancreas development (GO:0031018)7.84158393
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.09867885
4regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.94570555
5peptide hormone processing (GO:0016486)6.87707492
6COPII vesicle coating (GO:0048208)6.82761557
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.69182158
8regulation of type B pancreatic cell apoptotic process (GO:2000674)6.50659765
9type B pancreatic cell development (GO:0003323)6.45013555
10protein retention in ER lumen (GO:0006621)6.31193746
11glandular epithelial cell differentiation (GO:0002067)6.10883992
12exocrine pancreas development (GO:0031017)6.03665612
13meiotic chromosome segregation (GO:0045132)6.01321825
14cellular response to ATP (GO:0071318)5.91881145
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.87670051
16glandular epithelial cell development (GO:0002068)5.79141389
17positive regulation of nuclease activity (GO:0032075)5.60875858
18signal peptide processing (GO:0006465)5.41599401
19insulin secretion (GO:0030073)5.35006614
20GDP-mannose metabolic process (GO:0019673)5.34839581
21protein carboxylation (GO:0018214)5.15293661
22peptidyl-glutamic acid carboxylation (GO:0017187)5.15293661
23regulation of nuclease activity (GO:0032069)5.11214249
24positive regulation of protein kinase C signaling (GO:0090037)5.09351880
25vesicle coating (GO:0006901)5.09060665
26sequestering of metal ion (GO:0051238)5.04518379
27positive regulation of insulin secretion (GO:0032024)4.98681108
28DNA strand renaturation (GO:0000733)4.92195585
29endoplasmic reticulum unfolded protein response (GO:0030968)4.90716928
30nitric oxide mediated signal transduction (GO:0007263)4.85856337
31cellular response to unfolded protein (GO:0034620)4.77844786
32negative regulation of cell aging (GO:0090344)4.77311812
33positive regulation of synapse maturation (GO:0090129)4.71625566
34regulation of insulin secretion (GO:0050796)4.69260845
35cellular response to topologically incorrect protein (GO:0035967)4.64944429
36regulation of skeletal muscle contraction (GO:0014819)4.60994361
37ER-nucleus signaling pathway (GO:0006984)4.60699473
38negative regulation of glycoprotein biosynthetic process (GO:0010561)4.56072524
39ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.54004207
40columnar/cuboidal epithelial cell development (GO:0002066)4.49713527
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.48194539
42positive regulation of CREB transcription factor activity (GO:0032793)4.37313089
43urinary tract smooth muscle contraction (GO:0014848)4.35541471
44regulation of synapse structural plasticity (GO:0051823)4.33584524
45ER overload response (GO:0006983)4.28753204
46regulation of peptide hormone secretion (GO:0090276)4.28233306
47cellular response to vitamin D (GO:0071305)4.24958225
48behavioral response to nicotine (GO:0035095)4.23943411
49regulation of peptide secretion (GO:0002791)4.20616414
50purinergic nucleotide receptor signaling pathway (GO:0035590)4.20303494
51negative regulation of insulin secretion (GO:0046676)4.16807679
52peristalsis (GO:0030432)4.14881461
53regulation of synapse maturation (GO:0090128)4.10437027
54positive regulation of peptide hormone secretion (GO:0090277)4.06705441
55mannose metabolic process (GO:0006013)4.05754667
56L-alpha-amino acid transmembrane transport (GO:1902475)3.97351198
57adenosine receptor signaling pathway (GO:0001973)3.97025405
58negative regulation of norepinephrine secretion (GO:0010700)3.96739964
59response to endoplasmic reticulum stress (GO:0034976)3.93867493
60positive regulation of peptide secretion (GO:0002793)3.93328825
61protein N-linked glycosylation via asparagine (GO:0018279)3.92327641
62peptide hormone secretion (GO:0030072)3.91699177
63peptidyl-asparagine modification (GO:0018196)3.90464123
64intra-Golgi vesicle-mediated transport (GO:0006891)3.85881862
65peptide secretion (GO:0002790)3.84095165
66imidazole-containing compound metabolic process (GO:0052803)3.83983943
67cell migration in hindbrain (GO:0021535)3.83763725
68detection of calcium ion (GO:0005513)3.83318083
69response to ATP (GO:0033198)3.80066883
70ER to Golgi vesicle-mediated transport (GO:0006888)3.79000562
71lens fiber cell differentiation (GO:0070306)3.77063880
72toxin metabolic process (GO:0009404)3.75911470
73regulation of ARF GTPase activity (GO:0032312)3.72826954
74macroautophagy (GO:0016236)3.72128125
75response to unfolded protein (GO:0006986)3.69455717
76negative regulation of catecholamine secretion (GO:0033604)3.68383191
77regulation of hormone secretion (GO:0046883)3.66228889
78negative regulation of peptide hormone secretion (GO:0090278)3.62941451
79cellular zinc ion homeostasis (GO:0006882)3.61736082
80response to topologically incorrect protein (GO:0035966)3.60052679
81sensory perception of taste (GO:0050909)3.59718820
82epithelial cell fate commitment (GO:0072148)3.58373396
83protein N-linked glycosylation (GO:0006487)3.58055298
84response to hexose (GO:0009746)3.54261509
85protein targeting to vacuole (GO:0006623)3.52498715
86protein targeting to lysosome (GO:0006622)3.52498715
87establishment of protein localization to vacuole (GO:0072666)3.52498715
88sphingomyelin metabolic process (GO:0006684)3.50676776
89histone H3-K4 trimethylation (GO:0080182)3.50506315
90negative regulation of peptide secretion (GO:0002792)3.50401040
91astrocyte differentiation (GO:0048708)3.49986869
92response to glucose (GO:0009749)3.49333623
934-hydroxyproline metabolic process (GO:0019471)3.48086874
94regulation of peptide transport (GO:0090087)3.48001575
95G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.47824885
96negative regulation of glycoprotein metabolic process (GO:1903019)3.45085866
97phosphatidylglycerol biosynthetic process (GO:0006655)3.40856901
98Golgi organization (GO:0007030)3.40097443
99transepithelial transport (GO:0070633)3.38528192
100response to monosaccharide (GO:0034284)3.36732764
101sex determination (GO:0007530)3.34872042
102protein localization to Golgi apparatus (GO:0034067)3.32422103
103negative regulation of bone resorption (GO:0045779)3.30403922
104rRNA methylation (GO:0031167)3.30018077
105cerebellar Purkinje cell layer development (GO:0021680)3.29754080
106alkaloid metabolic process (GO:0009820)3.27862534
107response to hepatocyte growth factor (GO:0035728)3.26610624
108cellular response to hepatocyte growth factor stimulus (GO:0035729)3.26610624
109sulfur amino acid catabolic process (GO:0000098)3.24426795
110intestinal absorption (GO:0050892)3.23728142
111histone H3-K9 modification (GO:0061647)3.22899371
112cellular response to glucagon stimulus (GO:0071377)3.20405392
113folic acid metabolic process (GO:0046655)3.19570427
114positive regulation of glycolytic process (GO:0045821)3.19354511
115phosphatidylethanolamine biosynthetic process (GO:0006646)3.18585691
116regulation of hydrogen peroxide metabolic process (GO:0010310)3.16002688
117positive regulation of hormone secretion (GO:0046887)3.15700728
118detection of light stimulus involved in sensory perception (GO:0050962)3.14438875
119detection of light stimulus involved in visual perception (GO:0050908)3.14438875
120nucleoside transmembrane transport (GO:1901642)3.11795601
121histone H3-K9 methylation (GO:0051567)3.09761490
122intestinal epithelial cell development (GO:0060576)3.08733201
123peptide transport (GO:0015833)3.08604504
124regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.07837626
125central nervous system projection neuron axonogenesis (GO:0021952)3.06565122
126sialylation (GO:0097503)3.03891465
127hormone secretion (GO:0046879)3.03748513
128negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.03403687
129intestinal cholesterol absorption (GO:0030299)3.03153367
130glucose homeostasis (GO:0042593)3.02540943
131carbohydrate homeostasis (GO:0033500)3.02540943
132Golgi vesicle transport (GO:0048193)3.01047499
1333-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00489506
134purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00489506
135regulation of Golgi to plasma membrane protein transport (GO:0042996)3.00227221
136peptidyl-lysine methylation (GO:0018022)2.98162556
137response to carbohydrate (GO:0009743)2.96266698
138diol metabolic process (GO:0034311)2.94725304
139inner ear receptor cell development (GO:0060119)2.92976509
140tricarboxylic acid metabolic process (GO:0072350)2.90849195
141regulation of hexokinase activity (GO:1903299)2.90459818
142regulation of glucokinase activity (GO:0033131)2.90459818
143negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90002626
144purinergic receptor signaling pathway (GO:0035587)2.89917227
145cellular response to exogenous dsRNA (GO:0071360)2.88218254
146semaphorin-plexin signaling pathway (GO:0071526)2.88100800
147cellular anion homeostasis (GO:0030002)2.87768134
148chemosensory behavior (GO:0007635)2.87713558
149cellular response to vitamin (GO:0071295)2.87374564
150hormone transport (GO:0009914)2.86370962
151regulation of oxidative phosphorylation (GO:0002082)2.85366492
152regulation of protein kinase A signaling (GO:0010738)2.84945291
153regulation of energy homeostasis (GO:2000505)2.84320505
154phosphatidylethanolamine metabolic process (GO:0046337)2.83841406
155growth hormone secretion (GO:0030252)2.83749199
156protein autoprocessing (GO:0016540)2.83315450
157regulation of glucocorticoid secretion (GO:2000849)2.83228084
158triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82809779
159peptidyl-glutamic acid modification (GO:0018200)2.82500230
160positive regulation of heat generation (GO:0031652)2.80565899
161regulation of cytokine production involved in inflammatory response (GO:1900015)2.78116377
162neuromuscular synaptic transmission (GO:0007274)2.74992384
163negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.74909429
164CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74268620
165negative regulation of Rho protein signal transduction (GO:0035024)2.72709104
166histone H4 deacetylation (GO:0070933)2.71779137
167cAMP catabolic process (GO:0006198)2.71583518
168iron coordination entity transport (GO:1901678)2.69613124
169purine ribonucleotide transport (GO:0015868)2.66196183
170sphingosine metabolic process (GO:0006670)2.65221306
171snRNA transcription (GO:0009301)2.63491809
172UV protection (GO:0009650)2.62251551
173sphingoid metabolic process (GO:0046519)2.61865475
174protein import into peroxisome matrix (GO:0016558)2.61205426
175drug catabolic process (GO:0042737)2.58654857
176negative regulation of interleukin-8 production (GO:0032717)2.55930301
177regulation of nuclear cell cycle DNA replication (GO:0033262)2.55536706
178pericardium development (GO:0060039)2.54230847
179regulation of phospholipid biosynthetic process (GO:0071071)2.53499787
180positive regulation of protein dephosphorylation (GO:0035307)2.53192674
181negative regulation of catenin import into nucleus (GO:0035414)2.51880334
182negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51030673
183diacylglycerol metabolic process (GO:0046339)2.50456710
184interferon-gamma production (GO:0032609)2.49188100
185adenine nucleotide transport (GO:0051503)2.48594998
186activation of MAPKKK activity (GO:0000185)2.46659611
187serine family amino acid catabolic process (GO:0009071)2.46590718
188negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.45529251
189phosphate ion homeostasis (GO:0055062)2.45148854
190trivalent inorganic anion homeostasis (GO:0072506)2.45148854
191positive regulation of histone deacetylation (GO:0031065)2.44770107
192heme transport (GO:0015886)2.43706754
193secondary metabolite biosynthetic process (GO:0044550)2.43525109
194layer formation in cerebral cortex (GO:0021819)2.43518129
195snRNA processing (GO:0016180)2.42176578
196rRNA modification (GO:0000154)2.41522075
197histone H3 deacetylation (GO:0070932)2.41394650
198sympathetic nervous system development (GO:0048485)2.40714439
199Golgi transport vesicle coating (GO:0048200)11.2536410
200COPI coating of Golgi vesicle (GO:0048205)11.2536410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.55255306
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.41119424
3VDR_21846776_ChIP-Seq_THP-1_Human4.02280055
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.53792426
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.25879560
6* P68_20966046_ChIP-Seq_HELA_Human3.01119375
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.92968706
8MYC_22102868_ChIP-Seq_BL_Human2.36522979
9* E2F1_20622854_ChIP-Seq_HELA_Human2.36158405
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31892419
11* BCL6_27268052_Chip-Seq_Bcells_Human2.30856097
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.28025586
13* BCOR_27268052_Chip-Seq_Bcells_Human2.27457620
14* MAF_26560356_Chip-Seq_TH2_Human2.23629048
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.19073906
16* PHF8_20622854_ChIP-Seq_HELA_Human2.13508081
17SMC4_20622854_ChIP-Seq_HELA_Human2.08733594
18MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.01387470
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.00720605
20ELF1_20517297_ChIP-Seq_JURKAT_Human2.00204211
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.2752081
22KDM2B_26808549_Chip-Seq_DND41_Human1.99784301
23* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.97562755
24IGF1R_20145208_ChIP-Seq_DFB_Human1.96079578
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95197173
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.92186101
27RARB_24833708_ChIP-Seq_LIVER_Mouse1.90774079
28MAF_26560356_Chip-Seq_TH1_Human1.86341055
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.84590206
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.84134704
31VDR_24763502_ChIP-Seq_THP-1_Human1.81067738
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80698614
33TCF7_22412390_ChIP-Seq_EML_Mouse1.77185719
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76098492
35REST_21632747_ChIP-Seq_MESCs_Mouse1.75960701
36RARA_24833708_ChIP-Seq_LIVER_Mouse1.75343039
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74800694
38RXRA_24833708_ChIP-Seq_LIVER_Mouse1.74712259
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73379481
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.73167518
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71443945
42RACK7_27058665_Chip-Seq_MCF-7_Human1.70402461
43TP53_22127205_ChIP-Seq_IMR90_Human1.69293815
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69162291
45ERA_21632823_ChIP-Seq_H3396_Human1.64545504
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.64243029
47ZNF274_21170338_ChIP-Seq_K562_Hela1.63798735
48DROSHA_22980978_ChIP-Seq_HELA_Human1.62911286
49* SA1_27219007_Chip-Seq_ERYTHROID_Human1.62642961
50FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.62519212
51UTX_26944678_Chip-Seq_JUKART_Human1.59618396
52FOXP1_21924763_ChIP-Seq_HESCs_Human1.58888598
53OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57762392
54TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.57430949
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56999219
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56886241
57KDM2B_26808549_Chip-Seq_K562_Human1.56382405
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.54548124
59LXR_22158963_ChIP-Seq_LIVER_Mouse1.54276155
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54094009
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53251182
62CTCF_20526341_ChIP-Seq_ESCs_Human1.53126845
63TFEB_21752829_ChIP-Seq_HELA_Human1.52489864
64CTCF_21964334_ChIP-Seq_BJAB-B_Human1.49957485
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.49515153
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48971798
67* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47793937
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.46749608
69* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.46366736
70GATA1_19941826_ChIP-Seq_K562_Human1.46135962
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.45964320
72CTCF_21964334_Chip-Seq_Bcells_Human1.45707217
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45544810
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45092611
75SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44350984
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43591092
77CIITA_25753668_ChIP-Seq_RAJI_Human1.43144701
78REST_19997604_ChIP-ChIP_NEURONS_Mouse1.42930800
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.42521274
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42299952
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.41252958
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39929126
83OCT4_19829295_ChIP-Seq_ESCs_Human1.38881529
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.38611837
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37620344
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.35025358
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34323213
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33203095
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31469922
90OCT4_20526341_ChIP-Seq_ESCs_Human1.31198671
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30536327
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29500608
93ERG_20517297_ChIP-Seq_VCAP_Human1.28983195
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28683488
95TP63_22573176_ChIP-Seq_HFKS_Human1.28097079
96CLOCK_20551151_ChIP-Seq_293T_Human1.27981037
97FOXA1_25552417_ChIP-Seq_VCAP_Human1.26393836
98XRN2_22483619_ChIP-Seq_HELA_Human1.25933507
99CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25619228
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25419977
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25315295
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23285398
103JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.22665061
104NCOR1_26117541_ChIP-Seq_K562_Human1.22422566
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20592787
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.18391522
107SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17329370
108* SA1_27219007_Chip-Seq_Bcells_Human1.15844896
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.14875542
110* P300_27268052_Chip-Seq_Bcells_Human1.14818850
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12542795
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12505657
113ETS1_21867929_ChIP-Seq_TH2_Mouse1.12432381
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11265902
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09116819
116FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08537398
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07550901
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07411123
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07080035
120P53_21459846_ChIP-Seq_SAOS-2_Human1.07026808
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07008015
122RAC3_21632823_ChIP-Seq_H3396_Human1.06539156
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06437479
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06236393
125KLF4_19829295_ChIP-Seq_ESCs_Human1.06201704
126RUNX1_27514584_Chip-Seq_MCF-7_Human1.05940531
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05608631
128NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04895077
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04548191
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03835633
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01520932
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00376912
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.99987153
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99927476
135TP53_22573176_ChIP-Seq_HFKS_Human0.98243555
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97520161
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97408457
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97067866
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.95054777
140STAT3_23295773_ChIP-Seq_U87_Human0.94117804
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93470543
142GATA3_27048872_Chip-Seq_THYMUS_Human0.92822231
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.92116151
144VDR_22108803_ChIP-Seq_LS180_Human0.91483852
145PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90473436
146BCAT_22108803_ChIP-Seq_LS180_Human0.88643259
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87691535
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87294669
149GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85944735
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85514427
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85407822
152ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85170221
153CREB1_26743006_Chip-Seq_LNCaP_Human0.84807798
154LXR_22292898_ChIP-Seq_THP-1_Human0.84308860
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84089889
156RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82288891
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82142498
158FLI1_21867929_ChIP-Seq_TH2_Mouse0.81164382
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.80942485
160FOXH1_21741376_ChIP-Seq_ESCs_Human0.80743458
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80205054
162GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78783094
163GABP_17652178_ChIP-ChIP_JURKAT_Human0.78725671
164LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77496880
165MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77209354
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.77149085
167SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76421187
168SPI1_23127762_ChIP-Seq_K562_Human0.75487800
169ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75475887
170TBX20_22328084_ChIP-Seq_HEART_Mouse0.73071873
171TBX20_22080862_ChIP-Seq_HEART_Mouse0.73071873
172TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71596277
173PIAS1_25552417_ChIP-Seq_VCAP_Human0.71576390
174GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71447821
175SOX2_20726797_ChIP-Seq_SW620_Human0.71063860
176CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69253455
177CHD1_26751641_Chip-Seq_LNCaP_Human0.69138956
178ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.68709065
179ZFX_18555785_ChIP-Seq_MESCs_Mouse0.67951958
180ELF1_17652178_ChIP-ChIP_JURKAT_Human0.67850853
181SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67464428
182ETS1_22383799_ChIP-Seq_G1ME_Mouse0.67272265
183SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67009543
184CTCF_27219007_Chip-Seq_Bcells_Human0.66779264
185GATA3_26560356_Chip-Seq_TH2_Human0.66261721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.38215022
2MP0005171_absent_coat_pigmentation5.92735683
3MP0003136_yellow_coat_color5.55001286
4MP0002877_abnormal_melanocyte_morpholog5.47026475
5MP0005423_abnormal_somatic_nervous5.00839960
6MP0005174_abnormal_tail_pigmentation4.82903642
7MP0002693_abnormal_pancreas_physiology4.74403964
8MP0004043_abnormal_pH_regulation4.48599033
9MP0002909_abnormal_adrenal_gland4.41343839
10MP0009780_abnormal_chondrocyte_physiolo4.30602604
11MP0001944_abnormal_pancreas_morphology4.13897298
12MP0003195_calcinosis3.69003296
13MP0005379_endocrine/exocrine_gland_phen3.54278823
14MP0000013_abnormal_adipose_tissue3.47816875
15MP0000678_abnormal_parathyroid_gland3.36118764
16MP0005409_darkened_coat_color3.09555127
17MP0001188_hyperpigmentation3.06322258
18MP0002735_abnormal_chemical_nociception3.05379830
19MP0010386_abnormal_urinary_bladder2.96759310
20MP0008875_abnormal_xenobiotic_pharmacok2.96519342
21MP0005220_abnormal_exocrine_pancreas2.94649184
22MP0003183_abnormal_peptide_metabolism2.67096179
23MP0002078_abnormal_glucose_homeostasis2.52807534
24MP0001968_abnormal_touch/_nociception2.52736730
25MP0002837_dystrophic_cardiac_calcinosis2.49117535
26MP0004381_abnormal_hair_follicle2.47449725
27MP0000015_abnormal_ear_pigmentation2.37527406
28MP0005360_urolithiasis2.31567454
29MP0005646_abnormal_pituitary_gland2.03263970
30MP0004264_abnormal_extraembryonic_tissu1.98599022
31MP0000462_abnormal_digestive_system1.95894276
32MP0008789_abnormal_olfactory_epithelium1.95787542
33MP0005394_taste/olfaction_phenotype1.93839285
34MP0005499_abnormal_olfactory_system1.93839285
35MP0006072_abnormal_retinal_apoptosis1.93583103
36MP0003300_gastrointestinal_ulcer1.92934334
37MP0004130_abnormal_muscle_cell1.86436131
38MP0001986_abnormal_taste_sensitivity1.82836655
39MP0002234_abnormal_pharynx_morphology1.80922966
40MP0002928_abnormal_bile_duct1.77426359
41MP0000003_abnormal_adipose_tissue1.75598679
42MP0009053_abnormal_anal_canal1.73932263
43MP0008961_abnormal_basal_metabolism1.65095344
44MP0002896_abnormal_bone_mineralization1.61171573
45MP0003172_abnormal_lysosome_physiology1.60073963
46MP0001765_abnormal_ion_homeostasis1.52099508
47MP0003953_abnormal_hormone_level1.48449659
48MP0003868_abnormal_feces_composition1.48034666
49MP0002638_abnormal_pupillary_reflex1.47995432
50MP0005551_abnormal_eye_electrophysiolog1.44569821
51MP0000613_abnormal_salivary_gland1.43981511
52MP0005058_abnormal_lysosome_morphology1.38499083
53MP0009643_abnormal_urine_homeostasis1.36625956
54MP0003122_maternal_imprinting1.35353043
55MP0010329_abnormal_lipoprotein_level1.29515285
56MP0003252_abnormal_bile_duct1.26434062
57MP0002736_abnormal_nociception_after1.23013331
58MP0004270_analgesia1.22738763
59MP0002933_joint_inflammation1.21693753
60MP0000778_abnormal_nervous_system1.21085787
61MP0005535_abnormal_body_temperature1.20074955
62MP0005645_abnormal_hypothalamus_physiol1.19337374
63MP0002163_abnormal_gland_morphology1.17546381
64MP0005332_abnormal_amino_acid1.13882491
65MP0003119_abnormal_digestive_system1.12390638
66MP0001970_abnormal_pain_threshold1.11699482
67MP0005365_abnormal_bile_salt1.10360983
68MP0001270_distended_abdomen1.08027144
69MP0005310_abnormal_salivary_gland1.06874877
70MP0005257_abnormal_intraocular_pressure1.04833710
71MP0002139_abnormal_hepatobiliary_system1.04566606
72MP0003959_abnormal_lean_body1.04540012
73MP0006054_spinal_hemorrhage1.04025805
74MP0000631_abnormal_neuroendocrine_gland0.99560556
75MP0009384_cardiac_valve_regurgitation0.97789427
76MP0002138_abnormal_hepatobiliary_system0.96758160
77MP0005187_abnormal_penis_morphology0.94558247
78MP0001756_abnormal_urination0.94483717
79MP0002876_abnormal_thyroid_physiology0.93576710
80MP0002075_abnormal_coat/hair_pigmentati0.92035619
81MP0003866_abnormal_defecation0.91275104
82MP0000639_abnormal_adrenal_gland0.89967181
83MP0005451_abnormal_body_composition0.89535868
84MP0005636_abnormal_mineral_homeostasis0.89499702
85MP0005448_abnormal_energy_balance0.88540189
86MP0005584_abnormal_enzyme/coenzyme_acti0.85948085
87MP0001299_abnormal_eye_distance/0.84879163
88MP0003705_abnormal_hypodermis_morpholog0.83402651
89MP0001666_abnormal_nutrient_absorption0.83225234
90MP0003453_abnormal_keratinocyte_physiol0.82754414
91MP0001661_extended_life_span0.82664007
92MP0000230_abnormal_systemic_arterial0.81839225
93MP0005375_adipose_tissue_phenotype0.79619555
94MP0001873_stomach_inflammation0.78986469
95MP0003045_fibrosis0.77908572
96MP0009672_abnormal_birth_weight0.77612848
97MP0000681_abnormal_thyroid_gland0.77214724
98MP0004924_abnormal_behavior0.76796836
99MP0005386_behavior/neurological_phenoty0.76796836
100MP0003111_abnormal_nucleus_morphology0.75162061
101MP0009840_abnormal_foam_cell0.75133902
102MP0002063_abnormal_learning/memory/cond0.74794378
103MP0001764_abnormal_homeostasis0.74332721
104MP0000751_myopathy0.73325594
105MP0000371_diluted_coat_color0.73232301
106MP0003635_abnormal_synaptic_transmissio0.73032399
107MP0005083_abnormal_biliary_tract0.70994070
108MP0002118_abnormal_lipid_homeostasis0.70291944
109MP0001502_abnormal_circadian_rhythm0.69269116
110MP0003890_abnormal_embryonic-extraembry0.69105907
111MP0001324_abnormal_eye_pigmentation0.68765502
112MP0004145_abnormal_muscle_electrophysio0.67832432
113MP0005253_abnormal_eye_physiology0.66521495
114MP0002249_abnormal_larynx_morphology0.66262083
115MP0000367_abnormal_coat/_hair0.65040353
116MP0009642_abnormal_blood_homeostasis0.61783951
117MP0004142_abnormal_muscle_tone0.61436396
118MP0005377_hearing/vestibular/ear_phenot0.61361713
119MP0003878_abnormal_ear_physiology0.61361713
120MP0002184_abnormal_innervation0.60783047
121MP0000569_abnormal_digit_pigmentation0.60375826
122MP0000538_abnormal_urinary_bladder0.59027464
123MP0005334_abnormal_fat_pad0.59026792
124MP0009931_abnormal_skin_appearance0.59007959
125MP0002572_abnormal_emotion/affect_behav0.58771938
126MP0005670_abnormal_white_adipose0.57937064
127MP0009703_decreased_birth_body0.56485642
128MP0005501_abnormal_skin_physiology0.55927901
129MP0003795_abnormal_bone_structure0.55903726
130MP0005195_abnormal_posterior_eye0.55434669
131MP0003787_abnormal_imprinting0.54624987
132MP0002733_abnormal_thermal_nociception0.54470794
133MP0003879_abnormal_hair_cell0.54223877
134MP0005248_abnormal_Harderian_gland0.52597573
135MP0006292_abnormal_olfactory_placode0.51714244
136MP0005076_abnormal_cell_differentiation0.51351493
137MP0005452_abnormal_adipose_tissue0.51058748
138MP0002089_abnormal_postnatal_growth/wei0.50359355
139MP0002069_abnormal_eating/drinking_beha0.50353236
140MP0002653_abnormal_ependyma_morphology0.50012989
141MP0006276_abnormal_autonomic_nervous0.49971751
142MP0003121_genomic_imprinting0.49674479
143MP0001186_pigmentation_phenotype0.49014696
144MP0004036_abnormal_muscle_relaxation0.48509733
145MP0000955_abnormal_spinal_cord0.48273524
146MP0000534_abnormal_ureter_morphology0.47546438
147MP0001348_abnormal_lacrimal_gland0.46993934
148MP0002269_muscular_atrophy0.46454253
149MP0000609_abnormal_liver_physiology0.45705881
150MP0002136_abnormal_kidney_physiology0.45659399
151MP0002752_abnormal_somatic_nervous0.45650029
152MP0002160_abnormal_reproductive_system0.45632524
153MP0000470_abnormal_stomach_morphology0.45561276
154MP0002067_abnormal_sensory_capabilities0.45464034
155MP0002882_abnormal_neuron_morphology0.45023200
156MP0001731_abnormal_postnatal_growth0.44973891
157MP0001346_abnormal_lacrimal_gland0.44590068
158MP0003632_abnormal_nervous_system0.43860520
159MP0001849_ear_inflammation0.43258749
160MP0002168_other_aberrant_phenotype0.43057154
161MP0005085_abnormal_gallbladder_physiolo0.42623779
162MP0002970_abnormal_white_adipose0.42174620
163MP0000428_abnormal_craniofacial_morphol0.41865416
164MP0000163_abnormal_cartilage_morphology0.41699726

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)9.11301427
2Hypoglycemic seizures (HP:0002173)8.26224812
3Symptomatic seizures (HP:0011145)7.46815276
4Hypoglycemic coma (HP:0001325)7.29346262
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.79891918
6Insulin-resistant diabetes mellitus (HP:0000831)5.96826978
7Rib fusion (HP:0000902)5.55198965
8Abnormality of the pancreatic islet cells (HP:0006476)5.25084423
9Abnormality of endocrine pancreas physiology (HP:0012093)5.25084423
10Pancreatic islet-cell hyperplasia (HP:0004510)5.20624983
11Hyperglycemia (HP:0003074)5.17413844
12Large for gestational age (HP:0001520)4.76248973
13Ketoacidosis (HP:0001993)4.72493145
14Testicular atrophy (HP:0000029)4.60245802
15Poikiloderma (HP:0001029)4.60229964
16Abnormal pancreas size (HP:0012094)4.48993842
17Annular pancreas (HP:0001734)4.47332332
18Facial hemangioma (HP:0000329)4.47144966
19Late onset (HP:0003584)4.44392424
20Congenital stationary night blindness (HP:0007642)4.43275271
21Thin bony cortex (HP:0002753)4.41083527
22Abnormality of calcium-phosphate metabolism (HP:0100530)4.29605618
23Prolonged partial thromboplastin time (HP:0003645)4.29172265
24Ulnar bowing (HP:0003031)4.28176546
25Attenuation of retinal blood vessels (HP:0007843)4.23407137
26Vaginal fistula (HP:0004320)4.21864181
27Intestinal fistula (HP:0100819)4.20692978
28Decreased circulating renin level (HP:0003351)4.17363043
29Short chin (HP:0000331)4.12845392
30Rectal fistula (HP:0100590)4.09958602
31Rectovaginal fistula (HP:0000143)4.09958602
32Urinary glycosaminoglycan excretion (HP:0003541)4.03414293
33Mucopolysacchariduria (HP:0008155)4.03414293
34Hyperlipoproteinemia (HP:0010980)4.01858059
35Generalized aminoaciduria (HP:0002909)3.77671177
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.71768348
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.71768348
38Abnormality of polysaccharide metabolism (HP:0011012)3.71768348
39Dysostosis multiplex (HP:0000943)3.63422995
40Hemorrhage of the eye (HP:0011885)3.61570359
41Turricephaly (HP:0000262)3.56866703
42Patellar aplasia (HP:0006443)3.54781494
43Joint hemorrhage (HP:0005261)3.54419348
44Insulin resistance (HP:0000855)3.52193491
45Squamous cell carcinoma (HP:0002860)3.46428042
46Hypokalemia (HP:0002900)3.43830468
47Aplasia/Hypoplasia of the patella (HP:0006498)3.29913983
48Bony spicule pigmentary retinopathy (HP:0007737)3.17033283
49Osteomalacia (HP:0002749)3.14543241
50Akinesia (HP:0002304)3.06602407
51Abnormality of the intrinsic pathway (HP:0010989)3.04557078
52Delayed epiphyseal ossification (HP:0002663)3.03581012
53Agitation (HP:0000713)3.00092034
54Unilateral renal agenesis (HP:0000122)2.95827742
55Chorioretinal atrophy (HP:0000533)2.94746975
56Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.92391150
57Prominent metopic ridge (HP:0005487)2.92151385
58Coronal craniosynostosis (HP:0004440)2.91760470
59Hyperparathyroidism (HP:0000843)2.85156066
60Choroideremia (HP:0001139)2.84612589
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.84598880
62Thoracolumbar scoliosis (HP:0002944)2.81622151
63Abnormality of renin-angiotensin system (HP:0000847)2.79744472
64Ketosis (HP:0001946)2.75671107
65Narrow nasal bridge (HP:0000446)2.72319654
66Hypoalbuminemia (HP:0003073)2.72002147
67Abnormal albumin level (HP:0012116)2.72002147
68Limb hypertonia (HP:0002509)2.64357533
69Widely patent fontanelles and sutures (HP:0004492)2.63811359
70Abnormality of potassium homeostasis (HP:0011042)2.62976375
71Dyschromatopsia (HP:0007641)2.62705779
72Aplasia of the musculature (HP:0100854)2.62252796
73Conjugated hyperbilirubinemia (HP:0002908)2.61550248
74Bowed forearm bones (HP:0003956)2.59909983
75Bowing of the arm (HP:0006488)2.59909983
76Hypoalphalipoproteinemia (HP:0003233)2.59115123
77Joint stiffness (HP:0001387)2.56310394
78Papilledema (HP:0001085)2.53693711
79Capillary hemangiomas (HP:0005306)2.53626236
80Popliteal pterygium (HP:0009756)2.52531532
81Pendular nystagmus (HP:0012043)2.49856286
82Fetal akinesia sequence (HP:0001989)2.47176173
83Abnormality of the metopic suture (HP:0005556)2.46393251
84Retinal atrophy (HP:0001105)2.45735637
85Mesangial abnormality (HP:0001966)2.45286513
86Hypsarrhythmia (HP:0002521)2.44135774
87EEG with generalized epileptiform discharges (HP:0011198)2.43793020
88Hyperactive renin-angiotensin system (HP:0000841)2.43097739
89Flat occiput (HP:0005469)2.42826625
90Anteriorly placed anus (HP:0001545)2.40197867
91Exocrine pancreatic insufficiency (HP:0001738)2.38381535
92Polydipsia (HP:0001959)2.34402629
93Abnormal drinking behavior (HP:0030082)2.34402629
94Abdominal distention (HP:0003270)2.33773104
95Epileptiform EEG discharges (HP:0011182)2.32231488
96Hypophosphatemic rickets (HP:0004912)2.31351751
97Facial diplegia (HP:0001349)2.28471556
98Xanthomatosis (HP:0000991)2.27518648
99Hyperkalemia (HP:0002153)2.26881071
100Chronic hepatic failure (HP:0100626)2.25920933
101Neonatal respiratory distress (HP:0002643)2.24089617
102Gout (HP:0001997)2.20782318
103Progressive neurologic deterioration (HP:0002344)2.20480558
104Basal cell carcinoma (HP:0002671)2.18698186
105Decreased central vision (HP:0007663)2.18091027
106Small hand (HP:0200055)2.16869288
107Dysautonomia (HP:0002459)2.16567934
108Visual hallucinations (HP:0002367)2.14011558
109Increased number of teeth (HP:0011069)2.13737598
110Pheochromocytoma (HP:0002666)2.13628816
111Hypolipoproteinemia (HP:0010981)2.12921220
112Deep venous thrombosis (HP:0002625)2.12908955
113Abnormality of the costochondral junction (HP:0000919)2.12612700
114Hypothermia (HP:0002045)2.12084503
115Abnormality of homocysteine metabolism (HP:0010919)2.11821784
116Homocystinuria (HP:0002156)2.11821784
117Premature graying of hair (HP:0002216)2.11639073
118Hypophosphatemia (HP:0002148)2.11251975
119Chronic bronchitis (HP:0004469)2.10737517
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.09329084
121Gastrointestinal infarctions (HP:0005244)2.08535431
122Hypercortisolism (HP:0001578)2.08169798
123Hypoplasia of the pons (HP:0012110)2.06627243
124Tubular atrophy (HP:0000092)2.06239998
125Enlarged epiphyses (HP:0010580)2.05855354
126Protuberant abdomen (HP:0001538)2.04974700
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03671405
128Abnormal protein N-linked glycosylation (HP:0012347)2.03671405
129Abnormal protein glycosylation (HP:0012346)2.03671405
130Abnormal glycosylation (HP:0012345)2.03671405
131Abnormality of the common coagulation pathway (HP:0010990)2.03165206
132Choanal stenosis (HP:0000452)2.02110634
133Increased circulating renin level (HP:0000848)2.00075586
134Rectal prolapse (HP:0002035)1.99225627
135Cortical visual impairment (HP:0100704)1.99104533
136Skin nodule (HP:0200036)1.99052968
137Thin ribs (HP:0000883)1.97112729
138Elevated alkaline phosphatase (HP:0003155)1.96765799
139Pustule (HP:0200039)1.96631243
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95553376
141Male infertility (HP:0003251)1.94873739
142Restlessness (HP:0000711)1.94031850
143Hyperphosphaturia (HP:0003109)1.93804290
144Spina bifida occulta (HP:0003298)1.92176538
145Abnormality of the fingertips (HP:0001211)1.91054697
146Irregular vertebral endplates (HP:0003301)1.90221404
147Acute hepatic failure (HP:0006554)1.90197320
148Villous atrophy (HP:0011473)1.90014395
149Abnormality of small intestinal villus morphology (HP:0011472)1.90014395
150Hypotension (HP:0002615)1.89282975
151Abnormality of purine metabolism (HP:0004352)1.89193856
152Hypochromic anemia (HP:0001931)1.88728249
153Hyperphosphatemia (HP:0002905)1.88170056
154Birth length less than 3rd percentile (HP:0003561)1.88010805
155Hypokalemic alkalosis (HP:0001949)1.87881094
156Missing ribs (HP:0000921)1.86549196
157Hypoplastic nipples (HP:0002557)1.86502138
158Congenital glaucoma (HP:0001087)1.86027540
159Abnormality of alkaline phosphatase activity (HP:0004379)1.86007089
160Abnormality of DNA repair (HP:0003254)1.83541542
161Abnormality of the pons (HP:0007361)1.83149898
162Aplasia/Hypoplasia of the fovea (HP:0008060)1.81690762
163Hypoplasia of the fovea (HP:0007750)1.81690762
164Genetic anticipation (HP:0003743)1.80651387
165Protruding tongue (HP:0010808)1.80237864
166Abnormality of the hepatic vasculature (HP:0006707)1.78704366
167Abnormality of glycosphingolipid metabolism (HP:0004343)1.78675762
168Abnormality of glycolipid metabolism (HP:0010969)1.78675762
169Abnormality of liposaccharide metabolism (HP:0010968)1.78675762
170Absent thumb (HP:0009777)1.78484015
171Menstrual irregularities (HP:0000858)1.77802501
172Cerebellar dysplasia (HP:0007033)1.76527571
173Neuroendocrine neoplasm (HP:0100634)1.75955696
174Abnormality of the fovea (HP:0000493)1.75515625
175Abnormal enzyme/coenzyme activity (HP:0012379)1.75211261
176Hypobetalipoproteinemia (HP:0003563)1.74777787
177Tented upper lip vermilion (HP:0010804)1.74315707
178Cheilitis (HP:0100825)1.73846560
179Absent speech (HP:0001344)1.73545025
180Myoglobinuria (HP:0002913)1.72991585
181Polyuria (HP:0000103)1.72346967
182Increased cerebral lipofuscin (HP:0011813)1.71767279
183Irritability (HP:0000737)1.71220446
184Short thumb (HP:0009778)1.70530880
185Global brain atrophy (HP:0002283)1.69967707
186Abnormality of chloride homeostasis (HP:0011422)1.69950914
187Decreased subcutaneous fat (HP:0001002)1.69377731
188Abnormality of the nasal septum (HP:0000419)1.69179803
189Adrenal overactivity (HP:0002717)1.66913131
190Type I diabetes mellitus (HP:0100651)1.66075868
191Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66060056
192Severe short stature (HP:0003510)1.65921710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.30675095
2PASK6.98236905
3MAPK154.00034195
4TAOK33.71108307
5SIK23.35007207
6HIPK23.31125425
7ACVR1B3.29517153
8NTRK23.03903691
9PRKD32.92532659
10TLK12.89850608
11ERN12.79552830
12MAP3K22.59204904
13FLT32.56998576
14FRK2.14151069
15NTRK12.06016453
16BMPR1B2.02907790
17BLK1.96923952
18MAP3K11.88578121
19PDGFRA1.80059055
20PKN21.76243729
21SCYL21.74192783
22WNK41.70561962
23CAMKK21.56823260
24GRK61.52967546
25IRAK31.49001363
26EPHA31.44233442
27NTRK31.42839399
28MAP2K31.42176196
29UHMK11.40335604
30PTK21.36647988
31MUSK1.36626472
32MET1.31209784
33BRSK21.30601961
34TRIB31.27306443
35PRKCH1.26988513
36MELK1.26764251
37ICK1.24729412
38CDC42BPA1.23513454
39SIK11.16941840
40PTK61.16876863
41IRAK11.14612190
42MAP4K11.13010922
43DYRK1B1.12927104
44MARK11.12399551
45MAPK111.09584538
46NEK21.08742543
47TNK21.06138090
48MAP2K61.05615886
49PRKD21.04078427
50BCKDK0.98766940
51CDK120.98747618
52TYRO30.98735581
53DAPK20.96065555
54EIF2AK30.95797913
55MAPK120.94670128
56PAK30.93624121
57MAP2K40.89959938
58MAP3K70.88724837
59PDPK10.87657071
60MAP2K20.85097170
61TGFBR10.84065633
62FGFR20.77469980
63JAK20.75977633
64IRAK20.74912464
65CAMK1D0.74033553
66MAPK130.73962823
67EEF2K0.73352468
68ZAK0.72658662
69SGK4940.72253317
70SGK2230.72253317
71STK390.72203742
72JAK30.67988907
73RET0.67704086
74LMTK20.67454589
75ADRBK20.65300581
76ITK0.65270408
77FGFR40.64272828
78SIK30.63723258
79FER0.63424609
80DYRK30.63277618
81CCNB10.62416427
82TRIM280.61105471
83STK110.59643184
84PRKCE0.56422417
85BRD40.55305082
86RPS6KA60.54099964
87STK380.53789764
88PRKAA10.53259150
89MAP3K60.51791106
90MAP3K30.51404642
91JAK10.51192324
92PRKAA20.51110691
93WNK10.50865478
94BRSK10.50283301
95MAPK80.49257377
96PRKCI0.48541388
97AKT30.48530625
98ZAP700.47068357
99BMX0.45465168
100CAMKK10.44947295
101WNK30.44576962
102CAMK2D0.44416545
103PDK10.43322924
104NLK0.43244256
105RPS6KL10.42995181
106RPS6KC10.42995181
107CDK40.42936179
108ALK0.42563883
109TYK20.42121934
110EPHB10.41482576
111PRKACG0.40888135
112PRKD10.40759132
113IKBKB0.40475951
114GSK3A0.40211142
115BRAF0.39852840
116MARK20.39590324
117IGF1R0.37554680
118RIPK10.36316663
119PDGFRB0.35499950
120PKN10.35262860
121RPS6KA20.35205248
122TRPM70.34613370
123PINK10.34587910
124CDK50.33984560
125SYK0.33205198
126IRAK40.33116081
127TESK10.32634826
128BCR0.32459306
129RIPK40.31916220
130MTOR0.31375350
131PDK20.31268219
132SGK10.30617912
133FGFR30.29931358
134PRKACA0.29201892
135CSNK1A10.28671269
136PRKDC0.27343673
137CHUK0.26330645
138CAMK2B0.26278221
139KSR20.25924289
140EPHA20.25789929
141MAPK140.24878176
142RPS6KB10.23168912
143BTK0.22707887
144CSK0.21029580
145MAP3K100.19133766
146PRKCA0.18482912
147TEC0.18463439
148MAPK90.18044468
149MAP2K10.17803497
150ADRBK10.17373956
151MARK30.17252790
152GRK50.17058385
153NEK60.16461574
154LATS10.16192075
155RPS6KA30.14548582
156MAPK100.14448698
157AKT10.13979237
158CAMK1G0.13726395
159PIK3CG0.13506750
160PRKCG0.12390557

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.89408725
2Protein export_Homo sapiens_hsa030605.18329115
3Sulfur relay system_Homo sapiens_hsa041224.23081433
4Sulfur metabolism_Homo sapiens_hsa009203.38225583
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.30593926
6Insulin secretion_Homo sapiens_hsa049113.24486102
7Type II diabetes mellitus_Homo sapiens_hsa049302.69964892
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.45075104
9Type I diabetes mellitus_Homo sapiens_hsa049402.29852609
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.11642806
11Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.03016746
12Vibrio cholerae infection_Homo sapiens_hsa051101.96969858
13Selenocompound metabolism_Homo sapiens_hsa004501.96691536
14N-Glycan biosynthesis_Homo sapiens_hsa005101.70611456
15Caffeine metabolism_Homo sapiens_hsa002321.70010932
16Cocaine addiction_Homo sapiens_hsa050301.65100365
17Lysosome_Homo sapiens_hsa041421.55625298
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54756037
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.42646345
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28463923
21Nicotine addiction_Homo sapiens_hsa050331.25209605
22Pancreatic secretion_Homo sapiens_hsa049721.21250840
23Complement and coagulation cascades_Homo sapiens_hsa046101.21117297
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16370600
25Other glycan degradation_Homo sapiens_hsa005111.14685879
26Insulin resistance_Homo sapiens_hsa049311.14061087
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.13225868
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12207673
29Tryptophan metabolism_Homo sapiens_hsa003801.11220883
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11062379
31Amphetamine addiction_Homo sapiens_hsa050311.10772979
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09789238
33VEGF signaling pathway_Homo sapiens_hsa043701.09624060
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09081553
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08702011
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05337664
37Taste transduction_Homo sapiens_hsa047421.04309090
38Folate biosynthesis_Homo sapiens_hsa007901.03919084
39ABC transporters_Homo sapiens_hsa020101.01268856
40Glucagon signaling pathway_Homo sapiens_hsa049220.99986420
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99224054
42Ether lipid metabolism_Homo sapiens_hsa005650.93517284
43Butanoate metabolism_Homo sapiens_hsa006500.93250445
44Regulation of autophagy_Homo sapiens_hsa041400.92991620
45Fanconi anemia pathway_Homo sapiens_hsa034600.92443623
46Prolactin signaling pathway_Homo sapiens_hsa049170.90785158
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87506710
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.87194407
49Thyroid hormone synthesis_Homo sapiens_hsa049180.87176962
50Galactose metabolism_Homo sapiens_hsa000520.86559329
51Circadian rhythm_Homo sapiens_hsa047100.85107562
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.84807862
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81558999
54Notch signaling pathway_Homo sapiens_hsa043300.79696901
55Hedgehog signaling pathway_Homo sapiens_hsa043400.75035277
56Long-term potentiation_Homo sapiens_hsa047200.74845580
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73758549
58Axon guidance_Homo sapiens_hsa043600.73659033
59Prion diseases_Homo sapiens_hsa050200.73586183
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73359832
61Dopaminergic synapse_Homo sapiens_hsa047280.72605201
62One carbon pool by folate_Homo sapiens_hsa006700.71847976
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71712387
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.70383461
65Bile secretion_Homo sapiens_hsa049760.68515197
66Collecting duct acid secretion_Homo sapiens_hsa049660.67847395
67Synaptic vesicle cycle_Homo sapiens_hsa047210.67541232
68Cholinergic synapse_Homo sapiens_hsa047250.66997097
69Starch and sucrose metabolism_Homo sapiens_hsa005000.61178819
70Estrogen signaling pathway_Homo sapiens_hsa049150.60580852
71Chemical carcinogenesis_Homo sapiens_hsa052040.59752476
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.59706800
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.59393032
74Phenylalanine metabolism_Homo sapiens_hsa003600.59199050
75Calcium signaling pathway_Homo sapiens_hsa040200.59186487
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58978977
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58376486
78Circadian entrainment_Homo sapiens_hsa047130.58147045
79Choline metabolism in cancer_Homo sapiens_hsa052310.56935797
80TNF signaling pathway_Homo sapiens_hsa046680.56924198
81Phototransduction_Homo sapiens_hsa047440.56703290
82Serotonergic synapse_Homo sapiens_hsa047260.56536617
83Sphingolipid metabolism_Homo sapiens_hsa006000.56494127
84GABAergic synapse_Homo sapiens_hsa047270.55599281
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.54665992
86Fat digestion and absorption_Homo sapiens_hsa049750.54400950
87Retinol metabolism_Homo sapiens_hsa008300.53804323
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53787725
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53008899
90Vitamin digestion and absorption_Homo sapiens_hsa049770.52899715
91Insulin signaling pathway_Homo sapiens_hsa049100.52435570
92Glycerolipid metabolism_Homo sapiens_hsa005610.50573194
93Non-small cell lung cancer_Homo sapiens_hsa052230.49561802
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47896840
95MAPK signaling pathway_Homo sapiens_hsa040100.47672904
96Linoleic acid metabolism_Homo sapiens_hsa005910.46995500
97Alcoholism_Homo sapiens_hsa050340.46747765
98Histidine metabolism_Homo sapiens_hsa003400.45280466
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44231478
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43561666
101Lysine degradation_Homo sapiens_hsa003100.42752302
102GnRH signaling pathway_Homo sapiens_hsa049120.41407768
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.41057744
104Arginine biosynthesis_Homo sapiens_hsa002200.40371669
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40145549
106Fatty acid elongation_Homo sapiens_hsa000620.39688947
107mTOR signaling pathway_Homo sapiens_hsa041500.39501709
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39022020
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36745421
110Primary immunodeficiency_Homo sapiens_hsa053400.34298330
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.34196252
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33922286
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33172238
114Long-term depression_Homo sapiens_hsa047300.32355832
115Thyroid cancer_Homo sapiens_hsa052160.32153413
116Dorso-ventral axis formation_Homo sapiens_hsa043200.32078287
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31887953
118AMPK signaling pathway_Homo sapiens_hsa041520.31259049
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30903519
120B cell receptor signaling pathway_Homo sapiens_hsa046620.30495185
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30474957
122Antigen processing and presentation_Homo sapiens_hsa046120.28299370
123T cell receptor signaling pathway_Homo sapiens_hsa046600.27869088
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27362143
125Hippo signaling pathway_Homo sapiens_hsa043900.26838021
126Renin secretion_Homo sapiens_hsa049240.26725143
127Morphine addiction_Homo sapiens_hsa050320.26695634
128Basal cell carcinoma_Homo sapiens_hsa052170.26622307
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26615623
130Prostate cancer_Homo sapiens_hsa052150.26327206
131Protein digestion and absorption_Homo sapiens_hsa049740.25714040
132Tyrosine metabolism_Homo sapiens_hsa003500.25125608
133Bladder cancer_Homo sapiens_hsa052190.24102536
134cAMP signaling pathway_Homo sapiens_hsa040240.23954016
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23057415
136Inositol phosphate metabolism_Homo sapiens_hsa005620.22965782
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.20191997
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19571912
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.17644499
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16934783
141Fatty acid degradation_Homo sapiens_hsa000710.16910954
142Ovarian steroidogenesis_Homo sapiens_hsa049130.16748984
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16609159
144Melanogenesis_Homo sapiens_hsa049160.15791982
145Gap junction_Homo sapiens_hsa045400.12756716
146Phagosome_Homo sapiens_hsa041450.11880017
147FoxO signaling pathway_Homo sapiens_hsa040680.11621506
148Glutamatergic synapse_Homo sapiens_hsa047240.10416289
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10131246
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10041485
151Legionellosis_Homo sapiens_hsa051340.08659648
152Fructose and mannose metabolism_Homo sapiens_hsa000510.08334436
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.07803237

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