PRSS54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative serine-type endopeptidase containing the peptidase S1 domain. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.93010726
2axonemal dynein complex assembly (GO:0070286)9.92052237
3spermatid development (GO:0007286)9.75060478
4cilium or flagellum-dependent cell motility (GO:0001539)9.70947388
5motile cilium assembly (GO:0044458)9.66451491
6reproduction (GO:0000003)9.44691090
7regulation of cilium movement (GO:0003352)8.66499770
8cilium movement (GO:0003341)8.07609577
9protein targeting to Golgi (GO:0000042)7.75998470
10response to pheromone (GO:0019236)7.62361926
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.49572298
12establishment of protein localization to Golgi (GO:0072600)7.46566116
13single fertilization (GO:0007338)7.40609042
14rRNA methylation (GO:0031167)7.31732386
15sperm capacitation (GO:0048240)7.30459046
16retrograde transport, vesicle recycling within Golgi (GO:0000301)7.16697977
17piRNA metabolic process (GO:0034587)7.14135674
18negative regulation of inclusion body assembly (GO:0090084)7.01839081
19synaptonemal complex organization (GO:0070193)7.00203699
20male meiosis (GO:0007140)6.92880169
21synaptonemal complex assembly (GO:0007130)6.83677161
22spermatogenesis (GO:0007283)6.68752686
23male gamete generation (GO:0048232)6.66371045
24organic cation transport (GO:0015695)6.58859483
25microtubule depolymerization (GO:0007019)6.56043093
26rRNA modification (GO:0000154)6.45087630
27fertilization (GO:0009566)6.28479298
28gamete generation (GO:0007276)6.12507257
29regulation of inclusion body assembly (GO:0090083)5.90194151
30centriole replication (GO:0007099)5.78516199
31calcium ion-dependent exocytosis (GO:0017156)5.65870090
32protein localization to Golgi apparatus (GO:0034067)5.58531125
33germ cell development (GO:0007281)5.42676011
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.41082215
35phosphatidylethanolamine biosynthetic process (GO:0006646)5.37995414
36ventricular system development (GO:0021591)5.19100619
37regulation of microtubule-based movement (GO:0060632)5.10359205
38regulation of centriole replication (GO:0046599)5.10323398
39chromosome condensation (GO:0030261)5.06741252
40cell recognition (GO:0008037)5.05663194
41phosphatidylethanolamine metabolic process (GO:0046337)4.97357774
42spermatid nucleus differentiation (GO:0007289)4.89103614
43glycerol ether metabolic process (GO:0006662)4.84924279
44DNA packaging (GO:0006323)4.84234263
45multicellular organismal reproductive process (GO:0048609)4.82426577
46male meiosis I (GO:0007141)4.81295344
47microtubule severing (GO:0051013)4.73467294
48musculoskeletal movement (GO:0050881)4.66392461
49multicellular organismal movement (GO:0050879)4.66392461
50chromosome organization involved in meiosis (GO:0070192)4.64282781
51seminiferous tubule development (GO:0072520)4.62733933
52cellular ketone body metabolic process (GO:0046950)4.60742280
53DNA methylation involved in gamete generation (GO:0043046)4.57601222
54ether metabolic process (GO:0018904)4.48159736
55left/right pattern formation (GO:0060972)4.43504774
56microtubule nucleation (GO:0007020)4.27267647
57positive regulation of guanylate cyclase activity (GO:0031284)4.16334000
58meiotic nuclear division (GO:0007126)4.15731661
59sexual reproduction (GO:0019953)4.13175387
60ketone body metabolic process (GO:1902224)4.07115271
61chaperone-mediated protein complex assembly (GO:0051131)4.04241519
62positive regulation of Rab GTPase activity (GO:0032851)4.01353645
63regulation of Rab GTPase activity (GO:0032313)4.01353645
64glomerular visceral epithelial cell development (GO:0072015)3.96031668
65multicellular organismal development (GO:0007275)3.88453158
66meiosis I (GO:0007127)3.83511835
67regulation of guanylate cyclase activity (GO:0031282)3.82290894
68single strand break repair (GO:0000012)3.80780231
69regulation of transcription involved in cell fate commitment (GO:0060850)3.77677703
70glomerular epithelial cell development (GO:0072310)3.75507438
71sequestering of actin monomers (GO:0042989)3.54909282
72genitalia morphogenesis (GO:0035112)3.51534364
73protein polyglutamylation (GO:0018095)3.49054054
74protein localization to cilium (GO:0061512)3.44198837
75microtubule polymerization or depolymerization (GO:0031109)3.41843620
76meiotic cell cycle (GO:0051321)3.40972005
77negative regulation of Rho protein signal transduction (GO:0035024)3.40071936
78regulation of spindle checkpoint (GO:0090231)3.37851483
79protein K11-linked deubiquitination (GO:0035871)3.30237733
80monoubiquitinated protein deubiquitination (GO:0035520)3.28131556
81coenzyme catabolic process (GO:0009109)3.24499013
82protein refolding (GO:0042026)3.23644452
83regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.18907591
84regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.18907591
85carnitine transport (GO:0015879)3.16430462
86amino-acid betaine transport (GO:0015838)3.16430462
87intra-Golgi vesicle-mediated transport (GO:0006891)3.09104129
88behavioral response to cocaine (GO:0048148)3.08028705
89polyol catabolic process (GO:0046174)3.05348861
90nucleus organization (GO:0006997)3.05030835
91response to acidic pH (GO:0010447)3.02002541
92glycolytic process (GO:0006096)3.01238896
93nucleoside diphosphate phosphorylation (GO:0006165)3.00837455
94interferon-gamma secretion (GO:0072643)3.00141624
95carnitine transmembrane transport (GO:1902603)2.99038658
96cerebral cortex neuron differentiation (GO:0021895)2.98319418
97RNA destabilization (GO:0050779)2.97839239
98synaptic transmission, dopaminergic (GO:0001963)2.97122015
99alditol metabolic process (GO:0019400)2.96868407
100mitotic sister chromatid cohesion (GO:0007064)2.95223918
101cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.94820909
102positive regulation of macrophage activation (GO:0043032)2.94561430
103neurofilament cytoskeleton organization (GO:0060052)2.94070213
104mitochondrial fission (GO:0000266)2.92309862
105spinal cord motor neuron differentiation (GO:0021522)2.87294089
106cilium organization (GO:0044782)2.85772450
107RNA localization (GO:0006403)2.85120129
108protein depolymerization (GO:0051261)2.84024493
109microtubule-based movement (GO:0007018)2.80056210
110axoneme assembly (GO:0035082)2.78841294
111cilium assembly (GO:0042384)2.74700593
112cellular response to pH (GO:0071467)2.74123419
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73022822
114meiotic cell cycle process (GO:1903046)2.72753028
115GTP biosynthetic process (GO:0006183)2.72100767
116intraciliary transport (GO:0042073)2.71959583
117cilium morphogenesis (GO:0060271)2.71720870
118cellular component assembly involved in morphogenesis (GO:0010927)2.71333748
119negative regulation of organelle assembly (GO:1902116)2.71262683
120Golgi to endosome transport (GO:0006895)2.70485361
121regulation of cilium assembly (GO:1902017)2.68994938
122synapsis (GO:0007129)2.68178812
123regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.68024373
124prepulse inhibition (GO:0060134)2.67171998
125microtubule bundle formation (GO:0001578)2.66345805
126RNA methylation (GO:0001510)2.63216251
127polyamine biosynthetic process (GO:0006596)2.62118162
128peptidyl-glutamic acid modification (GO:0018200)2.55514901
129lactate metabolic process (GO:0006089)2.54993609
130gene silencing by RNA (GO:0031047)2.53466715
131centriole assembly (GO:0098534)2.51783333
132glycerol metabolic process (GO:0006071)2.50388989
133chromatin silencing (GO:0006342)2.44807875
134sperm motility (GO:0030317)13.8138961
135fusion of sperm to egg plasma membrane (GO:0007342)13.6722768
136cell wall macromolecule catabolic process (GO:0016998)13.4466339
137cell wall macromolecule metabolic process (GO:0044036)13.4466339
138acrosome reaction (GO:0007340)12.2560835
139sperm-egg recognition (GO:0035036)11.6475616
140acrosome assembly (GO:0001675)11.5275458
141multicellular organism reproduction (GO:0032504)10.9655271
142binding of sperm to zona pellucida (GO:0007339)10.5371177
143cell-cell recognition (GO:0009988)10.4265915
144plasma membrane fusion (GO:0045026)10.4164637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.56145174
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.36296754
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.37345942
4EZH2_22144423_ChIP-Seq_EOC_Human4.26969041
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88762699
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.11528929
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08500912
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.97112203
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83901825
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.70974603
11VDR_22108803_ChIP-Seq_LS180_Human2.41344211
12FUS_26573619_Chip-Seq_HEK293_Human2.29310983
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27815793
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21459617
15* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20784268
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.12471113
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07439408
18ZNF274_21170338_ChIP-Seq_K562_Hela2.02914738
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.96489963
20ERA_21632823_ChIP-Seq_H3396_Human1.95606152
21RAC3_21632823_ChIP-Seq_H3396_Human1.92227380
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85152627
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81668098
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80198143
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.80140467
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78367462
27VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78215310
28MYC_19829295_ChIP-Seq_ESCs_Human1.75338862
29STAT1_17558387_ChIP-Seq_HELA_Human1.72219547
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72008924
31NANOG_20526341_ChIP-Seq_ESCs_Human1.71174585
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70501835
33ER_23166858_ChIP-Seq_MCF-7_Human1.69733527
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69435030
35RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.67724634
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65852427
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63871527
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61515025
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.60940163
40RBPJ_21746931_ChIP-Seq_IB4_Human1.59754602
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.58237012
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57533048
43DROSHA_22980978_ChIP-Seq_HELA_Human1.57147882
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.56858002
45TAF2_19829295_ChIP-Seq_ESCs_Human1.56092110
46PHF8_20622854_ChIP-Seq_HELA_Human1.55536176
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.55214389
48CBX2_22325352_ChIP-Seq_293T-Rex_Human1.54767879
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54699820
50GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53836488
51CTCF_27219007_Chip-Seq_Bcells_Human1.52456038
52P300_19829295_ChIP-Seq_ESCs_Human1.52015139
53ETV1_20927104_ChIP-Seq_GIST48_Human1.50675707
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.46313814
55OCT4_20526341_ChIP-Seq_ESCs_Human1.46009927
56KDM2B_26808549_Chip-Seq_REH_Human1.45492331
57BCL6_27268052_Chip-Seq_Bcells_Human1.44626416
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.44218578
59CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44006721
60AR_25329375_ChIP-Seq_VCAP_Human1.43697818
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.42822781
62SMC4_20622854_ChIP-Seq_HELA_Human1.41999504
63CBP_20019798_ChIP-Seq_JUKART_Human1.41272507
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41272507
65P68_20966046_ChIP-Seq_HELA_Human1.40444115
66E2F1_20622854_ChIP-Seq_HELA_Human1.40342345
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39777421
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38440838
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38033284
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37011962
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.36963504
72PHF8_20622853_ChIP-Seq_HELA_Human1.36307139
73BCOR_27268052_Chip-Seq_Bcells_Human1.35656477
74P53_21459846_ChIP-Seq_SAOS-2_Human1.34473556
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34319375
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.34157271
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.33908529
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33664226
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33552272
80REST_21632747_ChIP-Seq_MESCs_Mouse1.33144236
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.33114237
82TBL1_22424771_ChIP-Seq_293T_Human1.31272535
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30507317
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28566703
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.27402828
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26520360
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24892526
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24677323
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.24207107
90GATA6_21074721_ChIP-Seq_CACO-2_Human1.24038723
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.24008510
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.23509353
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22955767
94GF1_26923725_Chip-Seq_HPCs_Mouse1.22833697
95* TP63_22573176_ChIP-Seq_HFKS_Human1.22687986
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.21676376
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20614695
98P300_27268052_Chip-Seq_Bcells_Human1.20497581
99TP53_18474530_ChIP-ChIP_U2OS_Human1.19688651
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19484349
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18775714
102GBX2_23144817_ChIP-Seq_PC3_Human1.16753276
103E2F1_17053090_ChIP-ChIP_MCF-7_Human1.16092948
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15446032
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15369622
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15369622
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15274859
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15035313
109GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14254781
110RUNX2_22187159_ChIP-Seq_PCA_Human1.13934855
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13661995
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13120155
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12643245
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.12619860
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11991984
116NFYA_21822215_ChIP-Seq_K562_Human1.11945259
117CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11922345
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.11619741
119NCOR_22424771_ChIP-Seq_293T_Human1.11414072
120SPI1_26923725_Chip-Seq_HPCs_Mouse1.11067125
121HOXB7_26014856_ChIP-Seq_BT474_Human1.10179649
122SMAD4_21799915_ChIP-Seq_A2780_Human1.09934174
123NANOG_19829295_ChIP-Seq_ESCs_Human1.09902733
124SOX2_19829295_ChIP-Seq_ESCs_Human1.09902733
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09603314
126STAT3_23295773_ChIP-Seq_U87_Human1.09324826
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09258598
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08531225
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07656444
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.07054391
131SA1_27219007_Chip-Seq_Bcells_Human1.06619420
132CEBPB_22108803_ChIP-Seq_LS180_Human1.06198305
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04553602
134RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03380770
135MYC_27129775_Chip-Seq_CORNEA_Mouse1.03204082
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.03116569
137ERG_20517297_ChIP-Seq_VCAP_Human1.02987453
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02857716
139ESET_19884257_ChIP-Seq_ESCs_Mouse1.01980251
140TAF15_26573619_Chip-Seq_HEK293_Human1.01798133
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01362490
142BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00648788
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00088132
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99926749
145RARA_24833708_ChIP-Seq_LIVER_Mouse0.98769331
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.98753013
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.98723184
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98641524
149JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97163154
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96402116
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.95934738
152OCT4_18555785_Chip-Seq_ESCs_Mouse0.95450391
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95233293
154P53_22387025_ChIP-Seq_ESCs_Mouse0.93610391
155CTCF_20526341_ChIP-Seq_ESCs_Human0.93511502
156LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93425940
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93223562
158NFYB_21822215_ChIP-Seq_K562_Human0.91918177
159FLI1_21867929_ChIP-Seq_CD8_Mouse0.90974546
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90436032
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89824415
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89672877
163SOX11_22085726_ChIP-Seq_ESNs_Mouse0.89417289
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.89244078
165OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89127084
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88598759
167ELF1_20517297_ChIP-Seq_JURKAT_Human0.88356702
168KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87556817
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87006914
170ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86877015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04919448
2MP0001929_abnormal_gametogenesis5.51205809
3MP0008877_abnormal_DNA_methylation4.00469658
4MP0002210_abnormal_sex_determination3.34521239
5MP0005451_abnormal_body_composition3.30389725
6MP0002161_abnormal_fertility/fecundity3.29846244
7MP0005670_abnormal_white_adipose2.98940175
8MP0001145_abnormal_male_reproductive2.85184775
9MP0003718_maternal_effect2.70213742
10MP0000653_abnormal_sex_gland2.47890221
11MP0001486_abnormal_startle_reflex2.37565376
12MP0002653_abnormal_ependyma_morphology2.37107442
13MP0001485_abnormal_pinna_reflex2.18368087
14MP0005410_abnormal_fertilization16.5469089
15MP0000678_abnormal_parathyroid_gland1.91136193
16MP0002160_abnormal_reproductive_system1.74117515
17MP0004233_abnormal_muscle_weight1.53321108
18MP0004859_abnormal_synaptic_plasticity1.51668084
19MP0003646_muscle_fatigue1.51337085
20MP0005379_endocrine/exocrine_gland_phen1.49270999
21MP0001188_hyperpigmentation1.46702418
22MP0002735_abnormal_chemical_nociception1.46557680
23MP0001905_abnormal_dopamine_level1.44366839
24MP0002249_abnormal_larynx_morphology1.43104707
25MP0005623_abnormal_meninges_morphology1.38569749
26MP0002132_abnormal_respiratory_system1.35523950
27MP0009053_abnormal_anal_canal1.29993427
28MP0001963_abnormal_hearing_physiology1.21666847
29MP0005395_other_phenotype1.19234392
30MP0002572_abnormal_emotion/affect_behav1.16267631
31MP0008789_abnormal_olfactory_epithelium1.16039882
32MP0009745_abnormal_behavioral_response1.15854638
33MP0002282_abnormal_trachea_morphology1.15516140
34MP0002067_abnormal_sensory_capabilities1.13277182
35MP0001765_abnormal_ion_homeostasis1.12523067
36MP0000955_abnormal_spinal_cord1.11209647
37MP0000026_abnormal_inner_ear1.03839296
38MP0002272_abnormal_nervous_system1.03706366
39MP0005394_taste/olfaction_phenotype1.03405676
40MP0005499_abnormal_olfactory_system1.03405676
41MP0001984_abnormal_olfaction1.02637315
42MP0002822_catalepsy1.01451967
43MP0001440_abnormal_grooming_behavior0.97825482
44MP0000566_synostosis0.97336736
45MP0000049_abnormal_middle_ear0.96826397
46MP0002557_abnormal_social/conspecific_i0.95332994
47MP0005310_abnormal_salivary_gland0.94844504
48MP0009697_abnormal_copulation0.94769488
49MP0002234_abnormal_pharynx_morphology0.90888780
50MP0001529_abnormal_vocalization0.89643902
51MP0006276_abnormal_autonomic_nervous0.86895325
52MP0005647_abnormal_sex_gland0.86341852
53MP0008995_early_reproductive_senescence0.85503828
54MP0003077_abnormal_cell_cycle0.85450707
55MP0005389_reproductive_system_phenotype0.84038145
56MP0009046_muscle_twitch0.83500930
57MP0003635_abnormal_synaptic_transmissio0.81752797
58MP0003011_delayed_dark_adaptation0.80583938
59MP0003693_abnormal_embryo_hatching0.80372644
60MP0005408_hypopigmentation0.79826466
61MP0008058_abnormal_DNA_repair0.79479509
62MP0006292_abnormal_olfactory_placode0.75787177
63MP0002127_abnormal_cardiovascular_syste0.75546537
64MP0003880_abnormal_central_pattern0.73414836
65MP0002733_abnormal_thermal_nociception0.73410942
66MP0003115_abnormal_respiratory_system0.71584992
67MP0002138_abnormal_hepatobiliary_system0.69875922
68MP0002064_seizures0.69460431
69MP0001501_abnormal_sleep_pattern0.68840680
70MP0005423_abnormal_somatic_nervous0.68715107
71MP0005084_abnormal_gallbladder_morpholo0.68444019
72MP0002734_abnormal_mechanical_nocicepti0.67504915
73MP0004085_abnormal_heartbeat0.66353336
74MP0002063_abnormal_learning/memory/cond0.66214570
75MP0001986_abnormal_taste_sensitivity0.64662714
76MP0005248_abnormal_Harderian_gland0.63417162
77MP0005636_abnormal_mineral_homeostasis0.62007484
78MP0000681_abnormal_thyroid_gland0.61575977
79MP0002882_abnormal_neuron_morphology0.60440425
80MP0005377_hearing/vestibular/ear_phenot0.60403904
81MP0003878_abnormal_ear_physiology0.60403904
82MP0001970_abnormal_pain_threshold0.59967588
83MP0005666_abnormal_adipose_tissue0.57209240
84MP0003137_abnormal_impulse_conducting0.56816954
85MP0001270_distended_abdomen0.55547034
86MP0000230_abnormal_systemic_arterial0.55034625
87MP0002752_abnormal_somatic_nervous0.51325800
88MP0001324_abnormal_eye_pigmentation0.50869776
89MP0001764_abnormal_homeostasis0.50288965
90MP0003329_amyloid_beta_deposits0.49767583
91MP0000516_abnormal_urinary_system0.48168330
92MP0005367_renal/urinary_system_phenotyp0.48168330
93MP0005535_abnormal_body_temperature0.48043529
94MP0002184_abnormal_innervation0.47798999
95MP0000358_abnormal_cell_content/0.47759429
96MP0010094_abnormal_chromosome_stability0.46704200
97MP0002102_abnormal_ear_morphology0.46098392
98MP0002269_muscular_atrophy0.45903494
99MP0005551_abnormal_eye_electrophysiolog0.45487279
100MP0003699_abnormal_female_reproductive0.45411323
101MP0004019_abnormal_vitamin_homeostasis0.44278633
102MP0004036_abnormal_muscle_relaxation0.43963090
103MP0003787_abnormal_imprinting0.43709506
104MP0000569_abnormal_digit_pigmentation0.43706392
105MP0005253_abnormal_eye_physiology0.43497967
106MP0003950_abnormal_plasma_membrane0.43064767
107MP0002736_abnormal_nociception_after0.42052236
108MP0002928_abnormal_bile_duct0.39486000
109MP0009278_abnormal_bone_marrow0.38949987
110MP0005397_hematopoietic_system_phenotyp0.38515082
111MP0001545_abnormal_hematopoietic_system0.38515082
112MP0001293_anophthalmia0.37057457
113MP0006036_abnormal_mitochondrial_physio0.36983719
114MP0009115_abnormal_fat_cell0.36133465
115MP0000604_amyloidosis0.35138106
116MP0003879_abnormal_hair_cell0.35098314
117MP0000534_abnormal_ureter_morphology0.32156955
118MP0003633_abnormal_nervous_system0.30020902
119MP0005391_vision/eye_phenotype0.29943534
120MP0004133_heterotaxia0.29797203
121MP0002971_abnormal_brown_adipose0.28939580
122MP0004811_abnormal_neuron_physiology0.27787950
123MP0001727_abnormal_embryo_implantation0.27705434
124MP0003111_abnormal_nucleus_morphology0.26371173
125MP0001968_abnormal_touch/_nociception0.26148127
126MP0006035_abnormal_mitochondrial_morpho0.25866094
127MP0001119_abnormal_female_reproductive0.25757281
128MP0002295_abnormal_pulmonary_circulatio0.25031815
129MP0003786_premature_aging0.22757317
130MP0003861_abnormal_nervous_system0.22729530
131MP0003948_abnormal_gas_homeostasis0.22356115
132MP0002152_abnormal_brain_morphology0.22286646
133MP0003942_abnormal_urinary_system0.22055500
134MP0003631_nervous_system_phenotype0.21558947
135MP0004270_analgesia0.21333898
136MP0001730_embryonic_growth_arrest0.21211469
137MP0002169_no_abnormal_phenotype0.20032198
138MP0002873_normal_phenotype0.19791198
139MP0004742_abnormal_vestibular_system0.18653794
140MP0005365_abnormal_bile_salt0.18221263
141MP0002229_neurodegeneration0.17895780
142MP0005375_adipose_tissue_phenotype0.17844775
143MP0001661_extended_life_span0.17279583
144MP0002139_abnormal_hepatobiliary_system0.16605738
145MP0008961_abnormal_basal_metabolism0.16574560
146MP0001348_abnormal_lacrimal_gland0.15805706
147MP0010307_abnormal_tumor_latency0.15335417
148MP0002405_respiratory_system_inflammati0.15301357
149MP0000751_myopathy0.15084685
150MP0003045_fibrosis0.14963328
151MP0008569_lethality_at_weaning0.13586252
152MP0008007_abnormal_cellular_replicative0.13498723
153MP0002092_abnormal_eye_morphology0.13211384
154MP0000313_abnormal_cell_death0.13092542
155MP0003959_abnormal_lean_body0.12893279
156MP0000001_mammalian_phenotype0.12709779
157MP0002118_abnormal_lipid_homeostasis0.12571595
158MP0005319_abnormal_enzyme/_coenzyme0.12549787
159MP0005195_abnormal_posterior_eye0.12498848
160MP0000462_abnormal_digestive_system0.12170483

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.37256286
2Abnormal respiratory epithelium morphology (HP:0012253)9.37256286
3Abnormal respiratory motile cilium physiology (HP:0012261)9.29285921
4Rhinitis (HP:0012384)7.59296892
5Abnormal ciliary motility (HP:0012262)7.30858724
6Chronic bronchitis (HP:0004469)7.28001821
7Infertility (HP:0000789)6.94682869
8Nasal polyposis (HP:0100582)6.39397262
9Severe visual impairment (HP:0001141)6.39178684
10Chronic hepatic failure (HP:0100626)5.36028445
11Abnormality of the nasal mucosa (HP:0000433)5.25044665
12Attenuation of retinal blood vessels (HP:0007843)4.64462703
13Bronchitis (HP:0012387)4.57529320
14Male infertility (HP:0003251)4.56396677
15Bronchiectasis (HP:0002110)4.50313357
16Bony spicule pigmentary retinopathy (HP:0007737)4.38212091
17Nephronophthisis (HP:0000090)4.18930880
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.15186425
19Abnormality of macular pigmentation (HP:0008002)3.94255867
20Cone-rod dystrophy (HP:0000548)3.83849897
21Resting tremor (HP:0002322)3.82445382
22Abnormal spermatogenesis (HP:0008669)3.56095742
23Amelogenesis imperfecta (HP:0000705)3.45373608
24Recurrent otitis media (HP:0000403)3.28294387
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.27827978
26Recurrent sinusitis (HP:0011108)3.26848142
27Hyperkalemia (HP:0002153)3.21064028
28Abnormality of dental color (HP:0011073)3.19074199
29Progressive sensorineural hearing impairment (HP:0000408)3.16574455
30Abnormality of the renal medulla (HP:0100957)3.14655572
31Progressive cerebellar ataxia (HP:0002073)3.05001100
32Hypoalphalipoproteinemia (HP:0003233)2.92136027
33Abnormal rod and cone electroretinograms (HP:0008323)2.91234050
34Impulsivity (HP:0100710)2.83151815
35Amblyopia (HP:0000646)2.82690514
36Tubulointerstitial nephritis (HP:0001970)2.81704219
37Recurrent bronchitis (HP:0002837)2.77214319
38Potter facies (HP:0002009)2.72925968
39Facial shape deformation (HP:0011334)2.72925968
40Hypoplastic ischia (HP:0003175)2.70650668
41Postural instability (HP:0002172)2.68365001
42Optic nerve hypoplasia (HP:0000609)2.64816746
43Hypoplasia of the thymus (HP:0000778)2.59050346
44Medial flaring of the eyebrow (HP:0010747)2.54718737
45Tubular atrophy (HP:0000092)2.53255685
46Generalized aminoaciduria (HP:0002909)2.52541228
47Abnormality of midbrain morphology (HP:0002418)2.48420999
48Molar tooth sign on MRI (HP:0002419)2.48420999
49Retinal dysplasia (HP:0007973)2.47096167
50Abnormal gallbladder physiology (HP:0012438)2.46019237
51Cholecystitis (HP:0001082)2.46019237
52Pancreatic cysts (HP:0001737)2.44999149
53Type II lissencephaly (HP:0007260)2.43734395
54Enlarged epiphyses (HP:0010580)2.43501806
55Gonadotropin excess (HP:0000837)2.43250409
56Truncal obesity (HP:0001956)2.41288343
57Tubulointerstitial abnormality (HP:0001969)2.40624751
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.36751887
59Renovascular hypertension (HP:0100817)2.36294571
60Abnormality of the ischium (HP:0003174)2.34473157
61Myokymia (HP:0002411)2.33651042
62Azoospermia (HP:0000027)2.31184745
63Insulin-resistant diabetes mellitus (HP:0000831)2.29326092
64Menstrual irregularities (HP:0000858)2.25058878
65Pancreatic fibrosis (HP:0100732)2.23147231
66Portal hypertension (HP:0001409)2.22495825
67Intellectual disability, moderate (HP:0002342)2.22440847
68Renal Fanconi syndrome (HP:0001994)2.21649478
69Pendular nystagmus (HP:0012043)2.19625653
70Dyschromatopsia (HP:0007641)2.14662684
71Abnormality of the costochondral junction (HP:0000919)2.14533974
72Glycosuria (HP:0003076)2.10235100
73Abnormality of urine glucose concentration (HP:0011016)2.10235100
74Abnormality of the hepatic vasculature (HP:0006707)2.08205881
75Polyuria (HP:0000103)2.07945765
76Abnormality of the aortic arch (HP:0012303)2.05325396
77Hyperuricemia (HP:0002149)2.03417434
78Increased purine levels (HP:0004368)2.03417434
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03339004
80Photophobia (HP:0000613)2.01545285
81Dynein arm defect of respiratory motile cilia (HP:0012255)13.4746453
82Absent/shortened dynein arms (HP:0200106)13.4746453
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0716756
84Occipital encephalocele (HP:0002085)1.98511710
85Spastic tetraparesis (HP:0001285)1.96754354
86Tubulointerstitial fibrosis (HP:0005576)1.93865922
87Congenital sensorineural hearing impairment (HP:0008527)1.92344700
88Choroideremia (HP:0001139)1.91767843
89Abnormality of potassium homeostasis (HP:0011042)1.88741385
90Tetany (HP:0001281)1.86460183
91Progressive hearing impairment (HP:0001730)1.86277958
92Decreased central vision (HP:0007663)1.85620557
93Focal segmental glomerulosclerosis (HP:0000097)1.84987610
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84323119
95Metaphyseal dysplasia (HP:0100255)1.81275462
96Stage 5 chronic kidney disease (HP:0003774)1.81268606
97Epileptic encephalopathy (HP:0200134)1.78980583
98Heterotopia (HP:0002282)1.75441656
99Respiratory distress (HP:0002098)1.74700767
100Polydipsia (HP:0001959)1.74211341
101Abnormal drinking behavior (HP:0030082)1.74211341
102Hypophosphatemic rickets (HP:0004912)1.73880515
103Postaxial foot polydactyly (HP:0001830)1.73204831
104Ventricular tachycardia (HP:0004756)1.70951339
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70910372
106Sclerocornea (HP:0000647)1.70557116
107Delayed epiphyseal ossification (HP:0002663)1.68977803
108Peripheral hypomyelination (HP:0007182)1.68454395
109Congenital hepatic fibrosis (HP:0002612)1.65865189
110Abnormality of renal excretion (HP:0011036)1.64240184
111Abnormality of the renal cortex (HP:0011035)1.62893268
112Hemorrhage of the eye (HP:0011885)1.60895081
113Neurofibrillary tangles (HP:0002185)1.60644242
114Double outlet right ventricle (HP:0001719)1.57469584
115Congenital malformation of the right heart (HP:0011723)1.57469584
116Abnormality of the lower motor neuron (HP:0002366)1.56030091
117Short ribs (HP:0000773)1.55517345
118Aplasia/Hypoplasia of the lens (HP:0008063)1.55218915
119Bell-shaped thorax (HP:0001591)1.52283726
120Abnormality of permanent molar morphology (HP:0011071)1.52141321
121Abnormality of the dental root (HP:0006486)1.52141321
122Taurodontia (HP:0000679)1.52141321
123Abnormal biliary tract physiology (HP:0012439)1.49893452
124Bile duct proliferation (HP:0001408)1.49893452
125Renal dysplasia (HP:0000110)1.48691512
126Oculomotor apraxia (HP:0000657)1.47822749
127Gait imbalance (HP:0002141)1.47044878
128Congenital primary aphakia (HP:0007707)1.46805190
129Chronic sinusitis (HP:0011109)1.44177443
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.43618631
131Abnormality of molar morphology (HP:0011070)1.42474701
132Abnormality of molar (HP:0011077)1.42474701
133Postaxial hand polydactyly (HP:0001162)1.42428363
134Fibular hypoplasia (HP:0003038)1.42121100
135Abnormality of the dental pulp (HP:0006479)1.40375854
136Abnormality of dentin (HP:0010299)1.39819427
137Bundle branch block (HP:0011710)1.36406783
138Easy fatigability (HP:0003388)1.34208467
139Asymmetric septal hypertrophy (HP:0001670)1.33996452
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33841808
141Absent epiphyses (HP:0010577)1.33841808
142Abnormal urine output (HP:0012590)1.31730590
143Deformed sella turcica (HP:0002681)1.31087963
144Cerebral inclusion bodies (HP:0100314)1.30773126
145Hemiparesis (HP:0001269)1.30189346
146Amyotrophic lateral sclerosis (HP:0007354)1.28728570
147Absent frontal sinuses (HP:0002688)1.28139001
148Facial cleft (HP:0002006)1.27662737
149Cystic liver disease (HP:0006706)1.25703398
150Cerebellar dysplasia (HP:0007033)1.25650816
151Fatigable weakness (HP:0003473)1.25149661
152Abnormality of the neuromuscular junction (HP:0003398)1.25149661
153Loss of speech (HP:0002371)1.24052231
154Sensory axonal neuropathy (HP:0003390)1.24030313
155Nephrogenic diabetes insipidus (HP:0009806)1.24014058
156Exercise-induced myalgia (HP:0003738)1.23954135
157Supernumerary spleens (HP:0009799)1.18623778
158Short femoral neck (HP:0100864)1.18567932
159Vascular calcification (HP:0004934)1.17797347
160Broad distal phalanx of finger (HP:0009836)1.16355709
161Nephropathy (HP:0000112)1.16352593
162Abnormality of saccadic eye movements (HP:0000570)1.15979521
163Constricted visual fields (HP:0001133)1.15975420
164Vaginal atresia (HP:0000148)1.15366581
165J-shaped sella turcica (HP:0002680)1.15240358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.94529621
2PDK37.94529621
3TESK16.66389875
4PRKD35.27137772
5PDK25.19290025
6ICK4.56588418
7PLK23.28700631
8DDR23.22898472
9BRD43.04262674
10MAP4K22.81785055
11PTK2B2.28771622
12WNK42.14004919
13STK392.08242583
14PIK3CG2.00871768
15PNCK1.98556142
16STK381.95021189
17MARK11.71961086
18NEK21.69203881
19DYRK1B1.60235068
20MAP3K111.44036331
21SIK21.35768067
22BMPR1B1.30660278
23OXSR11.29585403
24TRIM281.25373151
25PDK11.18795627
26CDK191.16626179
27MST1R1.01100617
28MAPK150.93477173
29BUB10.90508583
30CCNB10.90474471
31UHMK10.88233326
32DYRK30.88200835
33CDK70.88118943
34TYRO30.84396326
35EEF2K0.82977038
36WNK10.82629259
37IRAK10.82616095
38AKT30.81860296
39PDPK10.74300468
40CAMK10.73150462
41PASK0.68639170
42RIPK40.68549735
43PBK0.64907541
44MINK10.64816205
45NTRK30.64160163
46TESK20.63517742
47KSR20.61539301
48STK30.61000985
49TTK0.58006304
50CHEK20.57786436
51MAP2K70.56893664
52LATS10.56879914
53MAP2K60.56844101
54TIE10.56275906
55CAMK1D0.55885141
56CAMK1G0.55016493
57FGFR20.53631399
58PINK10.53087274
59LMTK20.51315608
60MAP3K90.48825079
61IRAK20.48690827
62TLK10.47854475
63MAP3K120.46991848
64DYRK1A0.40328659
65PRKAA20.40044135
66PAK10.38293651
67NTRK20.37800675
68MUSK0.36825925
69PRKCG0.36198488
70CHEK10.36083101
71NUAK10.35524271
72MAPK130.35307163
73CAMK40.34784639
74SRPK10.34214226
75MAPKAPK50.33391636
76DYRK20.32079388
77SGK4940.31337871
78SGK2230.31337871
79PAK20.30737266
80RPS6KA20.30235616
81PLK40.30214510
82STK38L0.30084296
83MAPK10.29508462
84LATS20.28417201
85MARK20.27246271
86ATM0.27171695
87MTOR0.26838251
88BCKDK0.26250943
89NEK60.26232352
90ARAF0.25492733
91MAP3K10.25076118
92PAK40.24077310
93WEE10.24025692
94MAP3K100.23496565
95ATR0.23372369
96CAMKK10.22693026
97CDK50.22481150
98FRK0.22037610
99CDK30.21841115
100MAP2K20.21760146
101MAPK100.20904894
102PRKAA10.18668942
103PRKCZ0.14739578
104PRKCQ0.13950165
105RPS6KB10.13873796
106CDK150.13524394
107PLK10.13048368
108CDK120.12711639
109INSRR0.11638251
110PKN10.11089698
111CDK180.10824067
112CDK11A0.09753181
113CDC70.08743627
114BRSK20.07418524
115WNK30.07132661
116CSNK2A10.06690784
117CLK10.06539781
118RPS6KA10.06355485
119GSK3B0.06233406
120CSF1R0.06197534
121CDK140.05672175
122CSNK1D0.05344082
123PRKG10.05264395
124PRKG20.04872057
125BRSK10.04732265
126PRKCB0.03982010
127PRKACG0.03543516
128CAMK2A0.03306539
129BRAF0.03090310
130STK100.02727551
131PRKCD0.02394941
132MARK30.02133039
133CDK20.02004066
134CDK10.01902209
135CDK60.01825256
136CSNK2A20.01386123
137STK110.01171946
138PRKCA0.01170423
139MAPK80.01064839
140EGFR0.01033820
141YES1-0.0426181
142PRKACA-0.0330260
143AURKA-0.0319743
144MAP3K4-0.0318415
145PRKDC-0.0315358
146PIM1-0.0228624
147PRKACB-0.0208083
148PAK6-0.0193644
149CDK4-0.0164373
150RPS6KA3-0.0161134

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.36385360
2Fatty acid biosynthesis_Homo sapiens_hsa000614.59918692
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.33984181
4Phototransduction_Homo sapiens_hsa047443.67462839
5Olfactory transduction_Homo sapiens_hsa047403.65258364
6Vitamin B6 metabolism_Homo sapiens_hsa007503.36171525
7Pyruvate metabolism_Homo sapiens_hsa006203.36044050
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.06451349
9Linoleic acid metabolism_Homo sapiens_hsa005912.97616825
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.63765712
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.59866012
12Propanoate metabolism_Homo sapiens_hsa006402.58446466
13Glucagon signaling pathway_Homo sapiens_hsa049222.53457960
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35273577
15Butanoate metabolism_Homo sapiens_hsa006502.34510658
16Basal transcription factors_Homo sapiens_hsa030222.26289800
17Nicotine addiction_Homo sapiens_hsa050332.23374683
18Selenocompound metabolism_Homo sapiens_hsa004502.13850781
19Glycerolipid metabolism_Homo sapiens_hsa005612.05236744
20Phenylalanine metabolism_Homo sapiens_hsa003601.97341266
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93698001
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91133734
23PPAR signaling pathway_Homo sapiens_hsa033201.88127301
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.86178988
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.69614546
26Pentose phosphate pathway_Homo sapiens_hsa000301.65269615
27Oocyte meiosis_Homo sapiens_hsa041141.65248365
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64771807
29Amphetamine addiction_Homo sapiens_hsa050311.62629846
30Dorso-ventral axis formation_Homo sapiens_hsa043201.62554806
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.61939789
32Fructose and mannose metabolism_Homo sapiens_hsa000511.59815795
33Morphine addiction_Homo sapiens_hsa050321.56933172
34Fat digestion and absorption_Homo sapiens_hsa049751.54779886
35Mineral absorption_Homo sapiens_hsa049781.50898831
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.50253839
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45644085
38Ether lipid metabolism_Homo sapiens_hsa005651.40041690
39Cardiac muscle contraction_Homo sapiens_hsa042601.39222534
40Oxidative phosphorylation_Homo sapiens_hsa001901.35599405
41Fanconi anemia pathway_Homo sapiens_hsa034601.34771421
42Fatty acid metabolism_Homo sapiens_hsa012121.34647472
43Fatty acid degradation_Homo sapiens_hsa000711.33738298
44Parkinsons disease_Homo sapiens_hsa050121.29079192
45Carbon metabolism_Homo sapiens_hsa012001.28177423
46Tyrosine metabolism_Homo sapiens_hsa003501.20327518
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18882361
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18073567
49Sulfur relay system_Homo sapiens_hsa041221.17536011
50RNA polymerase_Homo sapiens_hsa030201.16150230
51Renin secretion_Homo sapiens_hsa049241.13115778
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.12737276
53Huntingtons disease_Homo sapiens_hsa050161.08778545
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08726191
55GABAergic synapse_Homo sapiens_hsa047271.08082561
56Antigen processing and presentation_Homo sapiens_hsa046121.05775676
57Purine metabolism_Homo sapiens_hsa002301.02832975
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02791901
59Glutathione metabolism_Homo sapiens_hsa004801.01635125
60Collecting duct acid secretion_Homo sapiens_hsa049661.01080046
61Arginine and proline metabolism_Homo sapiens_hsa003301.00628841
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98678931
63mRNA surveillance pathway_Homo sapiens_hsa030150.96087924
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91850839
65Serotonergic synapse_Homo sapiens_hsa047260.91154056
66Insulin secretion_Homo sapiens_hsa049110.88539600
67Hedgehog signaling pathway_Homo sapiens_hsa043400.87922817
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.83944996
69Arachidonic acid metabolism_Homo sapiens_hsa005900.82665169
70RNA transport_Homo sapiens_hsa030130.80152360
71Alzheimers disease_Homo sapiens_hsa050100.80073290
72Chemical carcinogenesis_Homo sapiens_hsa052040.77734398
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.75943730
74Retinol metabolism_Homo sapiens_hsa008300.75422281
75Long-term potentiation_Homo sapiens_hsa047200.75072914
76Nitrogen metabolism_Homo sapiens_hsa009100.74321773
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73487877
78Estrogen signaling pathway_Homo sapiens_hsa049150.72378149
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71495675
80Biosynthesis of amino acids_Homo sapiens_hsa012300.70698525
81Bile secretion_Homo sapiens_hsa049760.68814088
82ABC transporters_Homo sapiens_hsa020100.68574055
83Thyroid hormone synthesis_Homo sapiens_hsa049180.68111663
84Systemic lupus erythematosus_Homo sapiens_hsa053220.67223302
85Homologous recombination_Homo sapiens_hsa034400.65212013
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64375155
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61871170
88Synaptic vesicle cycle_Homo sapiens_hsa047210.58709735
89Calcium signaling pathway_Homo sapiens_hsa040200.57475952
90Arginine biosynthesis_Homo sapiens_hsa002200.55353522
91Renin-angiotensin system_Homo sapiens_hsa046140.53910030
92Pancreatic secretion_Homo sapiens_hsa049720.53556361
93Salivary secretion_Homo sapiens_hsa049700.53362157
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51964127
95Taste transduction_Homo sapiens_hsa047420.51771230
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.51635599
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51437081
98Legionellosis_Homo sapiens_hsa051340.50218866
99Regulation of autophagy_Homo sapiens_hsa041400.50201238
100Protein digestion and absorption_Homo sapiens_hsa049740.47972470
101AMPK signaling pathway_Homo sapiens_hsa041520.46195576
102Endocytosis_Homo sapiens_hsa041440.45453540
103Tryptophan metabolism_Homo sapiens_hsa003800.44931931
104Gastric acid secretion_Homo sapiens_hsa049710.44623662
105Type I diabetes mellitus_Homo sapiens_hsa049400.43850341
106Dopaminergic synapse_Homo sapiens_hsa047280.42820253
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.42082898
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41512757
109Inositol phosphate metabolism_Homo sapiens_hsa005620.40884485
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38948135
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38618366
112Cholinergic synapse_Homo sapiens_hsa047250.38613767
113Metabolic pathways_Homo sapiens_hsa011000.37272501
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.37181953
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36071057
116Circadian entrainment_Homo sapiens_hsa047130.35951240
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.35271068
118Base excision repair_Homo sapiens_hsa034100.33786820
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33544789
120Alcoholism_Homo sapiens_hsa050340.33334901
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33334873
122Gap junction_Homo sapiens_hsa045400.33012706
123cAMP signaling pathway_Homo sapiens_hsa040240.32642345
124Autoimmune thyroid disease_Homo sapiens_hsa053200.32206165
125Viral myocarditis_Homo sapiens_hsa054160.31766279
126VEGF signaling pathway_Homo sapiens_hsa043700.31284129
127Pyrimidine metabolism_Homo sapiens_hsa002400.29653057
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29434579
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28253330
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27975778
131Allograft rejection_Homo sapiens_hsa053300.25993862
132Cocaine addiction_Homo sapiens_hsa050300.25690673
133N-Glycan biosynthesis_Homo sapiens_hsa005100.21894421
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18711381
135B cell receptor signaling pathway_Homo sapiens_hsa046620.13934258
136Type II diabetes mellitus_Homo sapiens_hsa049300.13771919
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12334319
138Sulfur metabolism_Homo sapiens_hsa009200.11569770
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.11545404
140Glutamatergic synapse_Homo sapiens_hsa047240.10657729
141Wnt signaling pathway_Homo sapiens_hsa043100.09600746
142HIF-1 signaling pathway_Homo sapiens_hsa040660.09449775
143Salmonella infection_Homo sapiens_hsa051320.07560934

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