PRSS57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1disruption of cells of other organism involved in symbiotic interaction (GO:0051818)8.69964414
2killing of cells in other organism involved in symbiotic interaction (GO:0051883)8.69964414
3neutrophil mediated immunity (GO:0002446)7.91458943
4negative regulation of growth of symbiont in host (GO:0044130)6.83144395
5negative regulation of growth of symbiont involved in interaction with host (GO:0044146)6.83144395
6modulation of growth of symbiont involved in interaction with host (GO:0044144)6.83144395
7regulation of growth of symbiont in host (GO:0044126)6.83144395
8killing of cells of other organism (GO:0031640)6.54400861
9disruption of cells of other organism (GO:0044364)6.54400861
10myeloid leukocyte mediated immunity (GO:0002444)6.34244840
11defense response to fungus (GO:0050832)6.27437650
12negative regulation of phagocytosis (GO:0050765)6.24652917
13negative regulation of B cell apoptotic process (GO:0002903)5.94373127
14response to fungus (GO:0009620)5.85252692
15ribosomal small subunit assembly (GO:0000028)5.64720919
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.33172072
17positive regulation of B cell differentiation (GO:0045579)5.21128291
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.90609289
19purine deoxyribonucleotide catabolic process (GO:0009155)4.84155969
20deoxyribonucleotide catabolic process (GO:0009264)4.79298801
21telomere maintenance via semi-conservative replication (GO:0032201)4.68061284
22deoxyribose phosphate catabolic process (GO:0046386)4.61495880
23DNA deamination (GO:0045006)4.59714799
24DNA strand elongation involved in DNA replication (GO:0006271)4.54371612
25pyrimidine nucleotide catabolic process (GO:0006244)4.46681339
26regulation of B cell apoptotic process (GO:0002902)4.42397847
27leukocyte mediated cytotoxicity (GO:0001909)4.40959590
28DNA strand elongation (GO:0022616)4.32654902
29respiratory burst (GO:0045730)4.30175835
30negative regulation of erythrocyte differentiation (GO:0045647)4.15213962
31definitive hemopoiesis (GO:0060216)4.14982789
32purine nucleotide salvage (GO:0032261)4.13777791
33reactive oxygen species biosynthetic process (GO:1903409)4.12995226
34pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.99684071
35cellular response to zinc ion (GO:0071294)3.99601858
36mucosal-associated lymphoid tissue development (GO:0048537)3.95294840
37Peyers patch development (GO:0048541)3.95294840
38positive regulation of megakaryocyte differentiation (GO:0045654)3.95152806
39deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.94420822
40telomere maintenance via recombination (GO:0000722)3.90919381
41leukocyte aggregation (GO:0070486)3.88708388
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86676835
43nucleotide salvage (GO:0043173)3.82464731
44mature B cell differentiation involved in immune response (GO:0002313)3.81784445
45DNA replication initiation (GO:0006270)3.80519411
46cotranslational protein targeting to membrane (GO:0006613)3.80318011
472-deoxyribonucleotide metabolic process (GO:0009394)3.80019866
48protein localization to kinetochore (GO:0034501)3.78782781
49protein targeting to ER (GO:0045047)3.77254004
50positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.74497763
51autophagic vacuole fusion (GO:0000046)3.73018012
52viral transcription (GO:0019083)3.68506332
53sequestering of metal ion (GO:0051238)3.68416900
54purine deoxyribonucleotide metabolic process (GO:0009151)3.64042700
55DNA unwinding involved in DNA replication (GO:0006268)3.62726116
56mitotic recombination (GO:0006312)3.61770205
57leukocyte migration involved in inflammatory response (GO:0002523)3.60873670
58translational termination (GO:0006415)3.60675032
59deoxyribose phosphate metabolic process (GO:0019692)3.60200566
60DNA replication checkpoint (GO:0000076)3.59324304
61protein localization to endoplasmic reticulum (GO:0070972)3.58882000
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57575695
63purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.55291186
64pentose-phosphate shunt (GO:0006098)3.53487397
65IMP metabolic process (GO:0046040)3.47894796
66cell killing (GO:0001906)3.45651715
67Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44676568
68dosage compensation (GO:0007549)3.42737241
69telomere maintenance via telomere lengthening (GO:0010833)3.41817273
70regulation of chemokine biosynthetic process (GO:0045073)3.40507667
71glucose 6-phosphate metabolic process (GO:0051156)3.39012552
72intra-S DNA damage checkpoint (GO:0031573)3.37965223
73pentose metabolic process (GO:0019321)3.35315516
74nucleobase biosynthetic process (GO:0046112)3.33305824
75IMP biosynthetic process (GO:0006188)3.29748978
76angiogenesis involved in wound healing (GO:0060055)3.28988561
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28935722
78regulation of B cell differentiation (GO:0045577)3.28220410
79cellular response to interferon-beta (GO:0035458)3.28149319
80translational elongation (GO:0006414)3.27079315
81NADPH regeneration (GO:0006740)3.26221836
82response to peptidoglycan (GO:0032494)3.25079993
83regulation of interleukin-8 biosynthetic process (GO:0045414)3.24324534
84leukotriene biosynthetic process (GO:0019370)3.22824170
85protein localization to chromosome, centromeric region (GO:0071459)3.22547587
86cellular extravasation (GO:0045123)3.22264409
87interaction with symbiont (GO:0051702)3.21822414
88ribosomal small subunit biogenesis (GO:0042274)3.21484852
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.20500155
90negative regulation of chemokine production (GO:0032682)3.20122782
91UV protection (GO:0009650)3.19622869
92endothelium development (GO:0003158)3.10363150
93deoxyribonucleotide metabolic process (GO:0009262)3.06608089
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06365837
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05559804
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.05559804
97protein complex biogenesis (GO:0070271)3.04846373
98neutrophil activation involved in immune response (GO:0002283)3.02912037
99nucleobase-containing small molecule interconversion (GO:0015949)3.02640088
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02006655
101mitochondrial respiratory chain complex I assembly (GO:0032981)3.02006655
102NADH dehydrogenase complex assembly (GO:0010257)3.02006655
103response to interferon-beta (GO:0035456)2.99411194
104CENP-A containing nucleosome assembly (GO:0034080)2.98275759
105positive regulation of gamma-delta T cell activation (GO:0046645)2.97187575
106kinetochore organization (GO:0051383)2.96262165
107cellular response to exogenous dsRNA (GO:0071360)2.94358204
108organelle membrane fusion (GO:0090174)2.91348210
109purine-containing compound salvage (GO:0043101)2.91303193
110positive regulation of prostaglandin secretion (GO:0032308)2.89677467
111maturation of SSU-rRNA (GO:0030490)2.89003264
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88719736
113deoxyribose phosphate biosynthetic process (GO:0046385)2.88683424
1142-deoxyribonucleotide biosynthetic process (GO:0009265)2.88683424
115base-excision repair, AP site formation (GO:0006285)2.88169914
116signal peptide processing (GO:0006465)2.87469813
117pinocytosis (GO:0006907)2.85417993
118mitochondrial respiratory chain complex assembly (GO:0033108)2.84895331
119cellular protein complex disassembly (GO:0043624)2.84840467
120mannosylation (GO:0097502)2.84694037
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82927390
122modification by host of symbiont morphology or physiology (GO:0051851)2.81558447
123positive regulation of granulocyte differentiation (GO:0030854)2.80748716
124translational initiation (GO:0006413)2.80508474
125immunoglobulin mediated immune response (GO:0016064)2.79554395
126chromatin remodeling at centromere (GO:0031055)2.79407751
127macrophage differentiation (GO:0030225)2.77682649
128translesion synthesis (GO:0019985)2.75909684
129hydrogen peroxide catabolic process (GO:0042744)2.75704124
130leukotriene metabolic process (GO:0006691)2.75614002
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73810473
132negative regulation of lymphocyte apoptotic process (GO:0070229)2.71995313
1333-UTR-mediated mRNA stabilization (GO:0070935)2.70460940
134regulation of mitochondrial translation (GO:0070129)2.70354309
135viral life cycle (GO:0019058)2.70151321
136aggressive behavior (GO:0002118)2.69745201
137mature B cell differentiation (GO:0002335)2.67938405
138negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.67529765
139protoporphyrinogen IX biosynthetic process (GO:0006782)2.66829051
140peptide catabolic process (GO:0043171)2.65593513
141microglial cell activation (GO:0001774)2.64597419
142estrogen biosynthetic process (GO:0006703)2.63645019
143ribosomal large subunit biogenesis (GO:0042273)2.63560253
144negative regulation of interleukin-8 production (GO:0032717)2.62714243
145pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62367721
146chaperone mediated protein folding requiring cofactor (GO:0051085)2.62017582
147kinetochore assembly (GO:0051382)2.61350410
148regulation of megakaryocyte differentiation (GO:0045652)2.60501194
149metallo-sulfur cluster assembly (GO:0031163)2.60215432
150iron-sulfur cluster assembly (GO:0016226)2.60215432
151regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60171632
152purine nucleobase biosynthetic process (GO:0009113)2.58488171
153cytochrome complex assembly (GO:0017004)2.58125335
154negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.57231947
155DNA ligation (GO:0006266)2.57203281
156oxidative phosphorylation (GO:0006119)2.57061459
157grooming behavior (GO:0007625)2.56892875
158telomere maintenance (GO:0000723)2.54390064
159protein complex disassembly (GO:0043241)2.53564791
160mast cell activation (GO:0045576)2.52674037
161telomere organization (GO:0032200)2.52157629
162pseudouridine synthesis (GO:0001522)2.51639275
163pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.50794767
164low-density lipoprotein particle remodeling (GO:0034374)2.50599598
165inflammatory response to antigenic stimulus (GO:0002437)2.50251381
166translation (GO:0006412)2.50164974
167attachment of spindle microtubules to kinetochore (GO:0008608)2.48985136
168L-serine metabolic process (GO:0006563)2.48078279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.14182846
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68797058
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40260431
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.33830444
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.18695396
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.10404813
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88574250
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88071039
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82397042
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.67241793
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64568813
12VDR_21846776_ChIP-Seq_THP-1_Human2.63756166
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.62567211
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60746357
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.54962556
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45492143
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36270523
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.32817896
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26923298
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.13352639
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12408870
22SPI1_23547873_ChIP-Seq_NB4_Human2.05982199
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05552447
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04344057
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03688855
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00740939
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00286882
28MYC_22102868_ChIP-Seq_BL_Human1.90214952
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90180583
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89632762
31SCL_19346495_ChIP-Seq_HPC-7_Human1.88604956
32VDR_23849224_ChIP-Seq_CD4+_Human1.86576751
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.86496390
34FOXP3_21729870_ChIP-Seq_TREG_Human1.86457891
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85700501
36VDR_24763502_ChIP-Seq_THP-1_Human1.85686341
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84361729
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83727406
39XRN2_22483619_ChIP-Seq_HELA_Human1.82281754
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82221351
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.81038153
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.78507756
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73541464
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72846214
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71374367
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.71295353
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71118074
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70973172
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.67740094
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61294513
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.60445013
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.59018044
53DCP1A_22483619_ChIP-Seq_HELA_Human1.58872083
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53914073
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51755495
56AR_21909140_ChIP-Seq_LNCAP_Human1.51430920
57BCL6_27268052_Chip-Seq_Bcells_Human1.50699790
58CIITA_25753668_ChIP-Seq_RAJI_Human1.48989378
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44581496
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44051309
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43521171
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43503422
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.43112134
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40563164
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38616883
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38375728
67GABP_19822575_ChIP-Seq_HepG2_Human1.38096558
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36956937
69TTF2_22483619_ChIP-Seq_HELA_Human1.35906066
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35431611
71MYB_26560356_Chip-Seq_TH2_Human1.34237727
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33746604
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.33708821
74P68_20966046_ChIP-Seq_HELA_Human1.33184152
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32554511
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31952936
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31592771
78MAF_26560356_Chip-Seq_TH2_Human1.30447773
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.30164604
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29926676
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29124377
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28601047
83ELK1_19687146_ChIP-ChIP_HELA_Human1.28034701
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27194587
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23462476
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.23301103
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21330763
88UTX_26944678_Chip-Seq_JUKART_Human1.21106405
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20349402
90P300_27268052_Chip-Seq_Bcells_Human1.20244183
91MYB_26560356_Chip-Seq_TH1_Human1.20160978
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19744293
93MAF_26560356_Chip-Seq_TH1_Human1.19731558
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19397593
95BCOR_27268052_Chip-Seq_Bcells_Human1.19233407
96SPI1_20517297_ChIP-Seq_HL60_Human1.18456443
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17760718
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17688667
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.16961612
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16361529
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14855006
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14821529
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14525268
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14053866
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.12640467
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.12616890
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12330650
108GATA1_22025678_ChIP-Seq_K562_Human1.11362425
109CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09585588
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08815522
111PHF8_20622854_ChIP-Seq_HELA_Human1.06984429
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.06956640
113* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06883223
114GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06810752
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06158327
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05747147
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04889543
118NOTCH1_21737748_ChIP-Seq_TLL_Human1.04762159
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03305641
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01520376
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99392847
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98011013
123KDM5A_27292631_Chip-Seq_BREAST_Human0.95737450
124PU_27001747_Chip-Seq_BMDM_Mouse0.95704735
125TFEB_21752829_ChIP-Seq_HELA_Human0.94842663
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89999061
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89886112
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89718259
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89308830
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87248683
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87144621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.48078300
2MP0003724_increased_susceptibility_to3.68781486
3MP0009278_abnormal_bone_marrow3.64059807
4MP0003693_abnormal_embryo_hatching3.58200739
5MP0010094_abnormal_chromosome_stability3.34628394
6MP0009785_altered_susceptibility_to3.22249053
7MP0008057_abnormal_DNA_replication3.19015789
8MP0003303_peritoneal_inflammation2.94481825
9MP0003806_abnormal_nucleotide_metabolis2.93196901
10MP0003436_decreased_susceptibility_to2.90074192
11MP0002166_altered_tumor_susceptibility2.70251224
12MP0003111_abnormal_nucleus_morphology2.62294047
13MP0000490_abnormal_crypts_of2.49545222
14MP0002419_abnormal_innate_immunity2.49245835
15MP0004957_abnormal_blastocyst_morpholog2.42464844
16MP0003172_abnormal_lysosome_physiology2.42201426
17MP0005174_abnormal_tail_pigmentation2.41586156
18MP0005025_abnormal_response_to2.27432001
19MP0003077_abnormal_cell_cycle2.26693654
20MP0001835_abnormal_antigen_presentation2.21529406
21MP0005397_hematopoietic_system_phenotyp2.20871718
22MP0001545_abnormal_hematopoietic_system2.20871718
23MP0009379_abnormal_foot_pigmentation2.06196350
24MP0002006_tumorigenesis2.04327336
25MP0003183_abnormal_peptide_metabolism2.00484880
26MP0002148_abnormal_hypersensitivity_rea2.00407577
27MP0008007_abnormal_cellular_replicative1.96699304
28MP0009333_abnormal_splenocyte_physiolog1.94131095
29MP0000858_altered_metastatic_potential1.93365414
30MP0005464_abnormal_platelet_physiology1.92940331
31MP0008058_abnormal_DNA_repair1.91427971
32MP0004808_abnormal_hematopoietic_stem1.89040209
33MP0002420_abnormal_adaptive_immunity1.85958713
34MP0005000_abnormal_immune_tolerance1.84597885
35MP0001819_abnormal_immune_cell1.80970387
36MP0002398_abnormal_bone_marrow1.79612914
37MP0003718_maternal_effect1.78932668
38MP0009697_abnormal_copulation1.78774449
39MP0003763_abnormal_thymus_physiology1.72496793
40MP0001853_heart_inflammation1.71212349
41MP0005075_abnormal_melanosome_morpholog1.70793483
42MP0000465_gastrointestinal_hemorrhage1.69880994
43MP0005671_abnormal_response_to1.63709837
44MP0003656_abnormal_erythrocyte_physiolo1.63654766
45MP0000716_abnormal_immune_system1.59755604
46MP0006054_spinal_hemorrhage1.58783927
47MP0002722_abnormal_immune_system1.58510852
48MP0005220_abnormal_exocrine_pancreas1.56480623
49MP0001533_abnormal_skeleton_physiology1.55180682
50MP0002452_abnormal_antigen_presenting1.54990783
51MP0001986_abnormal_taste_sensitivity1.53020614
52MP0005645_abnormal_hypothalamus_physiol1.53004110
53MP0000015_abnormal_ear_pigmentation1.52244946
54MP0002429_abnormal_blood_cell1.51446735
55MP0002723_abnormal_immune_serum1.51348636
56MP0000689_abnormal_spleen_morphology1.51012058
57MP0002095_abnormal_skin_pigmentation1.49796624
58MP0003186_abnormal_redox_activity1.47587750
59MP0002019_abnormal_tumor_incidence1.47100561
60MP0001800_abnormal_humoral_immune1.46243859
61MP0005409_darkened_coat_color1.45940879
62MP0005646_abnormal_pituitary_gland1.45828054
63MP0010155_abnormal_intestine_physiology1.42573132
64MP0001845_abnormal_inflammatory_respons1.38370511
65MP0003866_abnormal_defecation1.36224965
66MP0002405_respiratory_system_inflammati1.33467138
67MP0002822_catalepsy1.30832749
68MP0000372_irregular_coat_pigmentation1.30094815
69MP0000703_abnormal_thymus_morphology1.27621267
70MP0008995_early_reproductive_senescence1.26492705
71MP0000685_abnormal_immune_system1.25759504
72MP0000343_altered_response_to1.18466243
73MP0009765_abnormal_xenobiotic_induced1.16004322
74MP0001663_abnormal_digestive_system1.15888267
75MP0001764_abnormal_homeostasis1.11012441
76MP0009764_decreased_sensitivity_to1.09506028
77MP0010307_abnormal_tumor_latency1.07668267
78MP0000350_abnormal_cell_proliferation1.07063445
79MP0003787_abnormal_imprinting1.06334824
80MP0000681_abnormal_thyroid_gland1.06031638
81MP0008932_abnormal_embryonic_tissue1.05730148
82MP0004264_abnormal_extraembryonic_tissu1.00966428
83MP0003221_abnormal_cardiomyocyte_apopto1.00855699
84MP0001905_abnormal_dopamine_level0.99691283
85MP0004185_abnormal_adipocyte_glucose0.99626681
86MP0001873_stomach_inflammation0.98618870
87MP0004782_abnormal_surfactant_physiolog0.98389178
88MP0005084_abnormal_gallbladder_morpholo0.97537042
89MP0000313_abnormal_cell_death0.97307941
90MP0003786_premature_aging0.95436264
91MP0003191_abnormal_cellular_cholesterol0.94843100
92MP0006036_abnormal_mitochondrial_physio0.94441012
93MP0005410_abnormal_fertilization0.93577863
94MP0008469_abnormal_protein_level0.91758017
95MP0005165_increased_susceptibility_to0.91340670
96MP0005266_abnormal_metabolism0.88756639
97MP0004147_increased_porphyrin_level0.88690805
98MP0006035_abnormal_mitochondrial_morpho0.88008019
99MP0008873_increased_physiological_sensi0.87586890
100MP0005387_immune_system_phenotype0.85398632
101MP0001790_abnormal_immune_system0.85398632
102MP0002877_abnormal_melanocyte_morpholog0.84290851
103MP0005451_abnormal_body_composition0.79142712
104MP0005058_abnormal_lysosome_morphology0.78520327
105MP0002009_preneoplasia0.78345104
106MP0000249_abnormal_blood_vessel0.75331984
107MP0003075_altered_response_to0.75072267
108MP0001851_eye_inflammation0.75034818
109MP0001881_abnormal_mammary_gland0.72225325
110MP0005535_abnormal_body_temperature0.70735922
111MP0005376_homeostasis/metabolism_phenot0.69915122
112MP0009763_increased_sensitivity_to0.69666490
113MP0005164_abnormal_response_to0.68960930
114MP0005666_abnormal_adipose_tissue0.68865191
115MP0000358_abnormal_cell_content/0.68436901
116MP0002160_abnormal_reproductive_system0.67212542
117MP0005319_abnormal_enzyme/_coenzyme0.66982584
118MP0001730_embryonic_growth_arrest0.66133183
119MP0006292_abnormal_olfactory_placode0.65533644
120MP0002970_abnormal_white_adipose0.65413286
121MP0002132_abnormal_respiratory_system0.64012278
122MP0005381_digestive/alimentary_phenotyp0.62444910
123MP0005584_abnormal_enzyme/coenzyme_acti0.62094811
124MP0008874_decreased_physiological_sensi0.61423023
125MP0005390_skeleton_phenotype0.60628303
126MP0002089_abnormal_postnatal_growth/wei0.59885457
127MP0000371_diluted_coat_color0.59585477
128MP0002075_abnormal_coat/hair_pigmentati0.57814697
129MP0003448_altered_tumor_morphology0.57197650
130MP0001188_hyperpigmentation0.56469994

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)7.35246540
2Agammaglobulinemia (HP:0004432)5.58645757
3Reticulocytopenia (HP:0001896)5.11971528
4Chronic obstructive pulmonary disease (HP:0006510)4.89546406
5Obstructive lung disease (HP:0006536)4.89546406
6Recurrent abscess formation (HP:0002722)4.45690847
7Abnormal number of erythroid precursors (HP:0012131)4.38844228
8Reduced antithrombin III activity (HP:0001976)4.15481422
9Abnormality of cells of the erythroid lineage (HP:0012130)4.11682502
10Eosinophilia (HP:0001880)4.11437999
11Recurrent bacterial skin infections (HP:0005406)4.09877748
12Eczematoid dermatitis (HP:0000976)4.07971116
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.92906479
14Periodontitis (HP:0000704)3.92621542
15Granulocytopenia (HP:0001913)3.86785463
16Abnormality of the prostate (HP:0008775)3.82983911
17Aplastic anemia (HP:0001915)3.57621345
18Type I transferrin isoform profile (HP:0003642)3.52071973
19Chromsome breakage (HP:0040012)3.51454447
20Hepatocellular necrosis (HP:0001404)3.46171758
21Duplicated collecting system (HP:0000081)3.42081077
22B lymphocytopenia (HP:0010976)3.40124292
23Abnormality of B cell number (HP:0010975)3.40124292
24Abnormality of DNA repair (HP:0003254)3.32164451
25Entropion (HP:0000621)3.31936460
26Prolonged bleeding time (HP:0003010)3.29910285
27Papilledema (HP:0001085)3.29489978
28Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20296050
29Poikiloderma (HP:0001029)3.19097030
30Meningitis (HP:0001287)3.16726322
31Hepatic necrosis (HP:0002605)3.16341495
32Elevated erythrocyte sedimentation rate (HP:0003565)3.13972749
33Abnormality of the renal collecting system (HP:0004742)3.07323427
34IgM deficiency (HP:0002850)3.05025999
35Chronic otitis media (HP:0000389)3.00102359
36Increased muscle lipid content (HP:0009058)2.99770116
37Myositis (HP:0100614)2.98890876
38Abnormality of eosinophils (HP:0001879)2.98608391
39Mitochondrial inheritance (HP:0001427)2.98009080
40Dicarboxylic aciduria (HP:0003215)2.94204925
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94204925
42Abnormality of T cell physiology (HP:0011840)2.93601209
43Increased intramyocellular lipid droplets (HP:0012240)2.92552277
44Chest pain (HP:0100749)2.89633285
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88974116
46Abnormal protein N-linked glycosylation (HP:0012347)2.88974116
47Abnormal protein glycosylation (HP:0012346)2.88974116
48Abnormal glycosylation (HP:0012345)2.88974116
49Petechiae (HP:0000967)2.86534084
50Recurrent gram-negative bacterial infections (HP:0005420)2.81213855
51Hypertensive crisis (HP:0100735)2.76397747
52Neutropenia (HP:0001875)2.75336081
53Cerebral palsy (HP:0100021)2.67823624
54Abnormal mitochondria in muscle tissue (HP:0008316)2.65767168
55Mediastinal lymphadenopathy (HP:0100721)2.65571738
56Hypergammaglobulinemia (HP:0010702)2.63626845
57Pulmonary fibrosis (HP:0002206)2.62070932
58Severe combined immunodeficiency (HP:0004430)2.59399536
59Increased CSF lactate (HP:0002490)2.57310520
60Myelodysplasia (HP:0002863)2.53553838
61Epistaxis (HP:0000421)2.53157261
62Leukocytosis (HP:0001974)2.52436677
63Chronic mucocutaneous candidiasis (HP:0002728)2.48592201
64Recurrent cutaneous fungal infections (HP:0011370)2.48592201
65Abnormality of macrophages (HP:0004311)2.47569365
66Increased IgE level (HP:0003212)2.47385149
67Acute necrotizing encephalopathy (HP:0006965)2.47170976
68Macrocytic anemia (HP:0001972)2.45871356
69Abnormality of chromosome stability (HP:0003220)2.45803078
70Autoimmune hemolytic anemia (HP:0001890)2.44555452
71Pancytopenia (HP:0001876)2.44546433
72Ureteral stenosis (HP:0000071)2.43840734
73Spontaneous hematomas (HP:0007420)2.43509158
74Cellulitis (HP:0100658)2.43273559
75Hepatosplenomegaly (HP:0001433)2.42065770
76Bone marrow hypocellularity (HP:0005528)2.41718387
77Abnormality of male internal genitalia (HP:0000022)2.38108744
78Recurrent skin infections (HP:0001581)2.37051849
79Progressive muscle weakness (HP:0003323)2.35445283
80Acute encephalopathy (HP:0006846)2.34892019
81Gangrene (HP:0100758)2.34309443
82Abnormality of pyrimidine metabolism (HP:0004353)2.33604264
83Renal Fanconi syndrome (HP:0001994)2.33168032
84Abnormality of the preputium (HP:0100587)2.29748958
85Pallor (HP:0000980)2.28507587
86Cutaneous melanoma (HP:0012056)2.28375162
87Abnormality of the pleura (HP:0002103)2.27960182
88Pulmonary infiltrates (HP:0002113)2.26349168
89Recurrent viral infections (HP:0004429)2.23349932
90Autoimmune thrombocytopenia (HP:0001973)2.23162621
91Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23123589
92Seborrheic dermatitis (HP:0001051)2.22940166
93Sepsis (HP:0100806)2.22889888
94Hemoptysis (HP:0002105)2.22314753
95Recurrent fungal infections (HP:0002841)2.22022629
96Oral leukoplakia (HP:0002745)2.21908485
97Skin ulcer (HP:0200042)2.20426904
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18557534
99J-shaped sella turcica (HP:0002680)2.17106317
100Visual hallucinations (HP:0002367)2.16765350
101Lipid accumulation in hepatocytes (HP:0006561)2.16644421
102Stomatitis (HP:0010280)2.13904363
10311 pairs of ribs (HP:0000878)2.12902388
104Increased serum ferritin (HP:0003281)2.12587495
105Abnormality of iron homeostasis (HP:0011031)2.11666807
106Osteomyelitis (HP:0002754)2.08327275
107Abnormality of T cells (HP:0002843)2.07232221
108Ureteral obstruction (HP:0006000)2.04685328
109Severe visual impairment (HP:0001141)2.03611572
110Lactic acidosis (HP:0003128)2.01994873
111Clubbing of toes (HP:0100760)2.01316375
112Progressive microcephaly (HP:0000253)2.01228945
113Increased hepatocellular lipid droplets (HP:0006565)2.00913713
114Meckel diverticulum (HP:0002245)2.00146807
115Abnormality of transition element cation homeostasis (HP:0011030)1.99636915
116Acute myeloid leukemia (HP:0004808)1.98975751
117Thoracic kyphosis (HP:0002942)1.98240816
118Emotional lability (HP:0000712)1.97559904
119Exercise intolerance (HP:0003546)1.95684108
120Increased serum lactate (HP:0002151)1.95246130
121Combined immunodeficiency (HP:0005387)1.95050498
122Gingivitis (HP:0000230)1.94991372
123Rhabdomyolysis (HP:0003201)1.94778919
124Increased neuronal autofluorescent lipopigment (HP:0002074)1.94340452
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93293323
126Progressive macrocephaly (HP:0004481)1.92001916
127Abnormality of the thoracic spine (HP:0100711)1.91624736
128Ragged-red muscle fibers (HP:0003200)1.91188395
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.90531653
130Abnormality of the ileum (HP:0001549)1.90380031
131Nonimmune hydrops fetalis (HP:0001790)1.89914132
132Vasculitis (HP:0002633)1.89722450
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.88551853
134Glomerulopathy (HP:0100820)1.87942530
135Exertional dyspnea (HP:0002875)1.87810614
136Abnormality of cells of the lymphoid lineage (HP:0012140)1.87700629
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86753586
138Abnormality of the anterior horn cell (HP:0006802)1.86490124
139Degeneration of anterior horn cells (HP:0002398)1.86490124
140Abnormality of reticulocytes (HP:0004312)1.86082140
141Prostate neoplasm (HP:0100787)1.85566766
142Thrombophlebitis (HP:0004418)1.85460103
143Hypoplasia of the thymus (HP:0000778)1.84380701
144Lymphoma (HP:0002665)1.83600857
145Panhypogammaglobulinemia (HP:0003139)1.82142357
146Lymphopenia (HP:0001888)1.82058688
147Microvesicular hepatic steatosis (HP:0001414)1.81008368
148Abnormal delayed hypersensitivity skin test (HP:0002963)1.80656854
149Skin rash (HP:0000988)1.78820811
150Acute lymphatic leukemia (HP:0006721)1.75099844
151Cervical subluxation (HP:0003308)1.74872419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.94571468
2EIF2AK33.54443486
3STK163.52202949
4WEE13.43172655
5KDR3.31987071
6BUB13.12615958
7IRAK43.09106789
8NUAK13.08861051
9TESK22.53492526
10EIF2AK12.46848551
11FES2.34938799
12CDC72.33954635
13TEC2.31751257
14BRSK22.23922226
15MAP3K122.22037045
16FLT32.14457356
17PIM22.09266158
18MAP3K111.99344401
19BLK1.97131412
20TESK11.97125892
21TAOK31.87431046
22BTK1.80378014
23TBK11.78602964
24TNK21.76513098
25VRK11.73564611
26MAP2K31.72742030
27TLK11.66458340
28EEF2K1.56281445
29SRPK11.53675869
30MAP3K61.51529613
31KIT1.48524062
32NME21.44684227
33MAP4K21.41728844
34ZAP701.40379190
35CLK11.40299145
36CAMKK21.39161008
37MAP4K11.38805870
38ACVR1B1.30681968
39TNIK1.29456041
40CDK81.26927763
41BRSK11.26609644
42MATK1.20380270
43ATR1.17941154
44EIF2AK21.17040565
45CDK71.16840412
46LIMK11.16694018
47SYK1.16170222
48TSSK61.14092626
49MKNK11.13676130
50PBK1.09628748
51NEK21.08283172
52IRAK31.06402824
53IKBKB1.01476576
54MKNK21.01053350
55ZAK1.00811183
56ARAF0.99684694
57CCNB10.99424405
58PAK40.97071424
59MAPK40.91310908
60DAPK10.91209326
61PASK0.91085002
62PKN20.89119099
63PIM10.87368259
64RPS6KB20.86556968
65ABL20.84653286
66TGFBR10.84235362
67GRK60.83911310
68TRPM70.78363196
69NEK90.78101630
70CDK40.77608626
71JAK30.77267590
72TXK0.75900784
73RIPK40.75383111
74IKBKE0.75234873
75SCYL20.74665057
76CDK190.74499692
77AURKB0.73888742
78PLK10.73229210
79RPS6KL10.72446470
80RPS6KC10.72446470
81ILK0.72304132
82PIK3CG0.70625435
83RPS6KA60.69484573
84CSF1R0.69087867
85LYN0.68707048
86RPS6KA50.68068938
87TAOK20.66248551
88MYLK0.65109468
89RPS6KA40.63572607
90MAP3K80.63162729
91AURKA0.62899552
92MAPKAPK50.62300515
93DYRK30.61278647
94TYK20.61207686
95ITK0.60941771
96RAF10.60266596
97LRRK20.58799268
98PRKCQ0.58641418
99CHEK20.58339841
100NEK10.56796674
101PLK40.53582850
102TTK0.52581146
103BCKDK0.52172627
104ERN10.51697107
105CDK60.51416958
106BMPR20.51329205
107LCK0.51279310
108HCK0.50986603
109GRK70.50862993
110MAP3K10.50409512
111PRPF4B0.49970886
112MAP2K60.49248608
113STK40.49077790
114CSK0.47919415
115MAP2K20.47593173
116TIE10.47091561
117MAP3K140.46383340
118CDK90.46275426
119PLK30.46261698
120HIPK20.45753161
121CSNK2A20.45606630
122RPS6KA20.42870957
123MAPK30.42553484
124JAK10.41369781
125GRK50.40939630
126JAK20.40898666
127MAPKAPK30.40322869
128PRKCD0.39458080
129MAPK110.39302977
130SMG10.38767023
131STK100.38298839
132CSNK2A10.38062896
133RPS6KB10.37906853
134CDK120.36406498
135DYRK20.34356872
136TAF10.33167722
137CDK20.31199385
138MAP3K50.31172011
139ATM0.29921051
140DAPK20.28032452
141DAPK30.28029942
142ADRBK10.26471608
143BMPR1B0.26123603

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.31807779
2Ribosome_Homo sapiens_hsa030103.50559306
3Mismatch repair_Homo sapiens_hsa034303.23288490
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.20250286
5Base excision repair_Homo sapiens_hsa034103.17374180
6Homologous recombination_Homo sapiens_hsa034403.08503263
7Protein export_Homo sapiens_hsa030602.91276282
8Non-homologous end-joining_Homo sapiens_hsa034502.67425891
9Nucleotide excision repair_Homo sapiens_hsa034202.40277919
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27297938
11Pentose phosphate pathway_Homo sapiens_hsa000302.26831443
12N-Glycan biosynthesis_Homo sapiens_hsa005102.13156114
13Pyrimidine metabolism_Homo sapiens_hsa002402.02189887
14Spliceosome_Homo sapiens_hsa030402.01861801
15One carbon pool by folate_Homo sapiens_hsa006702.01300410
16Fanconi anemia pathway_Homo sapiens_hsa034601.96846517
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94797203
18Cell cycle_Homo sapiens_hsa041101.83434450
19Parkinsons disease_Homo sapiens_hsa050121.81584799
20RNA polymerase_Homo sapiens_hsa030201.79799447
21Allograft rejection_Homo sapiens_hsa053301.79029108
22Proteasome_Homo sapiens_hsa030501.75619361
23Leishmaniasis_Homo sapiens_hsa051401.72704292
24Oxidative phosphorylation_Homo sapiens_hsa001901.70306478
25Fatty acid elongation_Homo sapiens_hsa000621.69403416
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67704897
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60786040
28Autoimmune thyroid disease_Homo sapiens_hsa053201.53563494
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.50736543
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.48569941
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46934166
32RNA transport_Homo sapiens_hsa030131.45178255
33Graft-versus-host disease_Homo sapiens_hsa053321.45000123
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42359388
35Galactose metabolism_Homo sapiens_hsa000521.37046617
36Peroxisome_Homo sapiens_hsa041461.36846568
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34689619
38Type I diabetes mellitus_Homo sapiens_hsa049401.34419073
39Other glycan degradation_Homo sapiens_hsa005111.29190898
40Renin-angiotensin system_Homo sapiens_hsa046141.23246435
41Huntingtons disease_Homo sapiens_hsa050161.14559358
42RNA degradation_Homo sapiens_hsa030181.14460669
43Glutathione metabolism_Homo sapiens_hsa004801.12970139
44Purine metabolism_Homo sapiens_hsa002301.12762990
45Sulfur relay system_Homo sapiens_hsa041221.10046390
46Primary immunodeficiency_Homo sapiens_hsa053401.06867813
47Antigen processing and presentation_Homo sapiens_hsa046121.06403080
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06379282
49Butanoate metabolism_Homo sapiens_hsa006501.05670397
50Herpes simplex infection_Homo sapiens_hsa051681.02289004
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00210305
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00106860
53Staphylococcus aureus infection_Homo sapiens_hsa051500.93899075
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93753305
55Systemic lupus erythematosus_Homo sapiens_hsa053220.92050820
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.90901051
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90567602
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90244224
59Alzheimers disease_Homo sapiens_hsa050100.89118985
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.87443873
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87393921
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84632864
63p53 signaling pathway_Homo sapiens_hsa041150.82456375
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.82384592
65Measles_Homo sapiens_hsa051620.78570783
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76429761
67Legionellosis_Homo sapiens_hsa051340.75886165
68Fatty acid metabolism_Homo sapiens_hsa012120.74916975
69Tyrosine metabolism_Homo sapiens_hsa003500.74158156
70Biosynthesis of amino acids_Homo sapiens_hsa012300.72370632
71Starch and sucrose metabolism_Homo sapiens_hsa005000.71758920
72Basal transcription factors_Homo sapiens_hsa030220.70893922
73Fructose and mannose metabolism_Homo sapiens_hsa000510.70370457
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69495443
75Thyroid cancer_Homo sapiens_hsa052160.68497292
76Phagosome_Homo sapiens_hsa041450.66180217
77Vitamin B6 metabolism_Homo sapiens_hsa007500.65011209
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.64780094
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63448928
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63442187
81Carbon metabolism_Homo sapiens_hsa012000.62408559
82Pertussis_Homo sapiens_hsa051330.62197812
83Epstein-Barr virus infection_Homo sapiens_hsa051690.61231324
84Osteoclast differentiation_Homo sapiens_hsa043800.60834089
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59953248
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59757373
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.58467708
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58395493
89Rheumatoid arthritis_Homo sapiens_hsa053230.57930941
90Arachidonic acid metabolism_Homo sapiens_hsa005900.57479216
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55446327
92mRNA surveillance pathway_Homo sapiens_hsa030150.53696470
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.52957785
94Folate biosynthesis_Homo sapiens_hsa007900.48928743
95Phototransduction_Homo sapiens_hsa047440.48926159
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48060308
97Tryptophan metabolism_Homo sapiens_hsa003800.47620152
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47250869
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.47237681
100Tuberculosis_Homo sapiens_hsa051520.46895569
101Influenza A_Homo sapiens_hsa051640.46655909
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46426952
103Phenylalanine metabolism_Homo sapiens_hsa003600.46218933
104Viral myocarditis_Homo sapiens_hsa054160.46137420
105Hepatitis B_Homo sapiens_hsa051610.46086149
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45779013
107Apoptosis_Homo sapiens_hsa042100.44528571
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44254305
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43741116
110B cell receptor signaling pathway_Homo sapiens_hsa046620.43154989
111Regulation of autophagy_Homo sapiens_hsa041400.42804326
112Shigellosis_Homo sapiens_hsa051310.42496328
113Lysosome_Homo sapiens_hsa041420.41776566
114African trypanosomiasis_Homo sapiens_hsa051430.40484097
115Fatty acid degradation_Homo sapiens_hsa000710.40080201
116Hematopoietic cell lineage_Homo sapiens_hsa046400.39598715
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39149075
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38823824
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38751386
120Acute myeloid leukemia_Homo sapiens_hsa052210.38116983
121Olfactory transduction_Homo sapiens_hsa047400.37374826
122Asthma_Homo sapiens_hsa053100.37216194
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.36703691
124Caffeine metabolism_Homo sapiens_hsa002320.36480083
125Viral carcinogenesis_Homo sapiens_hsa052030.35800464
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34498245
127Platelet activation_Homo sapiens_hsa046110.33105734
128HTLV-I infection_Homo sapiens_hsa051660.32904956
129Sulfur metabolism_Homo sapiens_hsa009200.32546412
130Malaria_Homo sapiens_hsa051440.32526634
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31824517
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31541523
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.30380117
134Metabolic pathways_Homo sapiens_hsa011000.29895987
135Salmonella infection_Homo sapiens_hsa051320.28627321
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28495538
137Chemical carcinogenesis_Homo sapiens_hsa052040.28254134
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25080334

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