PRSS58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the trypsin family of serine proteases. This gene and several related trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. This gene was previously described as a trypsinogen-like pseudogene, but it is now thought to be a protein-coding gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.96107534
2spermatid development (GO:0007286)9.75125560
3epithelial cilium movement (GO:0003351)9.66180361
4plasma membrane fusion (GO:0045026)9.60380731
5motile cilium assembly (GO:0044458)9.53017373
6reproduction (GO:0000003)9.35774524
7axonemal dynein complex assembly (GO:0070286)9.26443367
8regulation of cilium movement (GO:0003352)8.52137237
9cilium or flagellum-dependent cell motility (GO:0001539)8.34486809
10cilium movement (GO:0003341)7.81068424
11negative regulation of inclusion body assembly (GO:0090084)7.49346663
12sperm capacitation (GO:0048240)7.28235972
13single fertilization (GO:0007338)7.22712488
14rRNA methylation (GO:0031167)7.08407257
15synaptonemal complex organization (GO:0070193)7.03517683
16synaptonemal complex assembly (GO:0007130)6.96171494
17piRNA metabolic process (GO:0034587)6.92256922
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.87253468
19male meiosis (GO:0007140)6.79132622
20microtubule depolymerization (GO:0007019)6.76691931
21spermatogenesis (GO:0007283)6.75000813
22male gamete generation (GO:0048232)6.72298813
23organic cation transport (GO:0015695)6.53786470
24gamete generation (GO:0007276)6.17182700
25response to pheromone (GO:0019236)6.15243214
26rRNA modification (GO:0000154)6.13750212
27fertilization (GO:0009566)6.08123269
28regulation of inclusion body assembly (GO:0090083)6.02260391
29sexual reproduction (GO:0019953)5.97547846
30regulation of acrosome reaction (GO:0060046)5.97494443
31calcium ion-dependent exocytosis (GO:0017156)5.67864296
32protein targeting to Golgi (GO:0000042)5.67070813
33chromosome condensation (GO:0030261)5.52819411
34establishment of protein localization to Golgi (GO:0072600)5.43893685
35glycerol ether metabolic process (GO:0006662)5.41503087
36germ cell development (GO:0007281)5.41464170
37DNA packaging (GO:0006323)5.34334276
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.27830027
39retrograde transport, vesicle recycling within Golgi (GO:0000301)5.21137590
40spermatid nucleus differentiation (GO:0007289)5.11993218
41regulation of microtubule-based movement (GO:0060632)5.06487798
42ether metabolic process (GO:0018904)4.99776356
43ventricular system development (GO:0021591)4.90611377
44multicellular organismal reproductive process (GO:0048609)4.85286623
45chromosome organization involved in meiosis (GO:0070192)4.82915595
46cell recognition (GO:0008037)4.82114299
47regulation of female gonad development (GO:2000194)4.66242342
48centriole replication (GO:0007099)4.66096833
49phosphatidylethanolamine biosynthetic process (GO:0006646)4.59935880
50DNA methylation involved in gamete generation (GO:0043046)4.55746614
51male meiosis I (GO:0007141)4.48490836
52response to acidic pH (GO:0010447)4.43964974
53seminiferous tubule development (GO:0072520)4.37967316
54single strand break repair (GO:0000012)4.23871505
55phosphatidylethanolamine metabolic process (GO:0046337)4.20838667
56microtubule severing (GO:0051013)4.19449983
57cellular response to pH (GO:0071467)4.15112570
58left/right pattern formation (GO:0060972)4.11205119
59protein localization to Golgi apparatus (GO:0034067)4.02868452
60regulation of cytokine production involved in inflammatory response (GO:1900015)4.02610464
61histone H3-K9 demethylation (GO:0033169)4.00478437
62chaperone-mediated protein complex assembly (GO:0051131)3.95106372
63meiotic nuclear division (GO:0007126)3.91488713
64multicellular organismal development (GO:0007275)3.89898500
65positive regulation of Rab GTPase activity (GO:0032851)3.88541388
66regulation of Rab GTPase activity (GO:0032313)3.88541388
67regulation of centriole replication (GO:0046599)3.70045074
68positive regulation of uterine smooth muscle contraction (GO:0070474)3.68974927
69cellular ketone body metabolic process (GO:0046950)3.63957472
70meiosis I (GO:0007127)3.51052579
71oocyte development (GO:0048599)3.47016184
72meiotic cell cycle (GO:0051321)3.42518102
73microtubule polymerization or depolymerization (GO:0031109)3.42292651
74protein kinase C signaling (GO:0070528)3.42286067
75polyamine biosynthetic process (GO:0006596)3.42093878
76protein polyglutamylation (GO:0018095)3.41059065
77glycolytic process (GO:0006096)3.39756827
78protein K11-linked deubiquitination (GO:0035871)3.38804314
79regulation of transcription involved in cell fate commitment (GO:0060850)3.37542162
80genitalia morphogenesis (GO:0035112)3.36598823
81alditol metabolic process (GO:0019400)3.32632459
82sequestering of actin monomers (GO:0042989)3.32528251
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21238459
84ketone body metabolic process (GO:1902224)3.19510527
85glomerular visceral epithelial cell development (GO:0072015)3.19494134
86protein refolding (GO:0042026)3.15675540
87glycine transport (GO:0015816)3.11887055
88fructose metabolic process (GO:0006000)3.07171532
89RNA localization (GO:0006403)3.03628378
90synapsis (GO:0007129)3.01352631
91negative regulation of retinoic acid receptor signaling pathway (GO:0048387)26.4188907
92regulation of retinoic acid receptor signaling pathway (GO:0048385)21.9915950
93peptidyl-glutamic acid modification (GO:0018200)2.99984301
94nucleus organization (GO:0006997)2.99873691
95glomerular epithelial cell development (GO:0072310)2.99747384
96regulation of spindle checkpoint (GO:0090231)2.96136297
97sleep (GO:0030431)2.95188098
98axoneme assembly (GO:0035082)2.91544225
99polyol catabolic process (GO:0046174)2.90505719
100glycerol metabolic process (GO:0006071)2.86178482
101carnitine transport (GO:0015879)2.85077204
102amino-acid betaine transport (GO:0015838)2.85077204
103negative regulation of skeletal muscle tissue development (GO:0048642)2.83628961
104protein localization to cilium (GO:0061512)2.81703725
105regulation of uterine smooth muscle contraction (GO:0070472)2.80249322
106nucleoside diphosphate phosphorylation (GO:0006165)2.79659666
107detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.79423753
108regulation of female receptivity (GO:0045924)2.76231422
109regulation of cilium assembly (GO:1902017)2.75982451
110multicellular organismal movement (GO:0050879)2.75479568
111musculoskeletal movement (GO:0050881)2.75479568
112negative regulation of glycogen biosynthetic process (GO:0045719)2.74596859
113positive regulation of macrophage activation (GO:0043032)2.72703276
114mitotic sister chromatid cohesion (GO:0007064)2.71160595
115centriole assembly (GO:0098534)2.70599300
116drinking behavior (GO:0042756)2.68315320
117cerebral cortex neuron differentiation (GO:0021895)2.68164450
118meiotic cell cycle process (GO:1903046)2.66897262
119microtubule-based movement (GO:0007018)2.66004109
120carnitine transmembrane transport (GO:1902603)2.65314534
121cilium organization (GO:0044782)2.63942596
122monoubiquitinated protein deubiquitination (GO:0035520)2.63910919
123negative regulation of organelle assembly (GO:1902116)2.63706027
124protein depolymerization (GO:0051261)2.60767655
125positive regulation of humoral immune response (GO:0002922)2.60324623
126chromatin silencing (GO:0006342)2.58201112
127RNA destabilization (GO:0050779)2.58103678
128GTP biosynthetic process (GO:0006183)2.57657850
129cilium assembly (GO:0042384)2.55718556
130microtubule nucleation (GO:0007020)2.53740246
131positive regulation of RNA splicing (GO:0033120)2.52859090
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52048976
133cellular component assembly involved in morphogenesis (GO:0010927)2.49774840
134mitochondrion degradation (GO:0000422)2.49278010
135cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.49066198
136aggressive behavior (GO:0002118)2.47203541
137sperm motility (GO:0030317)14.4732007
138cell wall macromolecule catabolic process (GO:0016998)12.7226540
139cell wall macromolecule metabolic process (GO:0044036)12.7226540
140fusion of sperm to egg plasma membrane (GO:0007342)12.6522709
141acrosome reaction (GO:0007340)12.4876847
142sperm-egg recognition (GO:0035036)11.1299552
143acrosome assembly (GO:0001675)10.9525475
144multicellular organism reproduction (GO:0032504)10.3241071
145binding of sperm to zona pellucida (GO:0007339)10.1846208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.94900099
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.73884267
3EZH2_22144423_ChIP-Seq_EOC_Human4.63901461
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.43426964
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30044550
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26426627
7VDR_22108803_ChIP-Seq_LS180_Human2.94706350
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85610367
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63892191
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40664487
11ETV1_20927104_ChIP-Seq_GIST48_Human2.37244334
12RBPJ_21746931_ChIP-Seq_IB4_Human2.35522387
13NANOG_20526341_ChIP-Seq_ESCs_Human2.29393765
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.23225561
15RAC3_21632823_ChIP-Seq_H3396_Human2.22359789
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22185845
17ZNF274_21170338_ChIP-Seq_K562_Hela2.13373768
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10756592
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07940422
20PHF8_20622853_ChIP-Seq_HELA_Human2.00171162
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.99591444
22CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.97502264
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97078223
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.96601695
25HNFA_21074721_ChIP-Seq_CACO-2_Human1.96273672
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94911867
27ERA_21632823_ChIP-Seq_H3396_Human1.90641388
28AUTS2_25519132_ChIP-Seq_293T-REX_Human1.90362159
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88484542
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.87403915
31E2F1_20622854_ChIP-Seq_HELA_Human1.85768320
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84891568
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.83356040
34GATA6_21074721_ChIP-Seq_CACO-2_Human1.81284151
35GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.80632901
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.80360409
37STAT1_17558387_ChIP-Seq_HELA_Human1.79058316
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78407521
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.76611627
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.75803747
41CTCF_20526341_ChIP-Seq_ESCs_Human1.75477156
42CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.71531455
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70999297
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68966199
45BCL6_27268052_Chip-Seq_Bcells_Human1.66151039
46TAF2_19829295_ChIP-Seq_ESCs_Human1.65639318
47OCT4_20526341_ChIP-Seq_ESCs_Human1.65151264
48KDM2B_26808549_Chip-Seq_REH_Human1.62532576
49BCOR_27268052_Chip-Seq_Bcells_Human1.61350402
50SOX2_22085726_ChIP-Seq_NPCs_Mouse1.60950400
51CBX2_22325352_ChIP-Seq_293T-Rex_Human1.60347654
52MYC_19829295_ChIP-Seq_ESCs_Human1.59351166
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58964070
54P68_20966046_ChIP-Seq_HELA_Human1.58462662
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.57167601
56FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53980078
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51994413
58PHF8_20622854_ChIP-Seq_HELA_Human1.51867175
59NFYA_21822215_ChIP-Seq_K562_Human1.51605750
60PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.49446152
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.49431994
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.49130829
63SMC4_20622854_ChIP-Seq_HELA_Human1.46323320
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44823371
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44222048
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43115110
67CTCF_27219007_Chip-Seq_Bcells_Human1.42195011
68GATA3_21867929_ChIP-Seq_CD8_Mouse1.41000778
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.40584356
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40466280
71TAF15_26573619_Chip-Seq_HEK293_Human1.38623780
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37278097
73WDR5_24793694_ChIP-Seq_LNCAP_Human1.36733988
74TP63_22573176_ChIP-Seq_HFKS_Human1.35289866
75CBP_20019798_ChIP-Seq_JUKART_Human1.33745489
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33745489
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33296636
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.32317585
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31248007
80REST_21632747_ChIP-Seq_MESCs_Mouse1.31112279
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.30935564
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.30921116
83STAT1_20625510_ChIP-Seq_HELA_Human1.30685587
84AR_25329375_ChIP-Seq_VCAP_Human1.30262928
85P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28366836
86SOX2_21211035_ChIP-Seq_LN229_Human1.28303868
87DROSHA_22980978_ChIP-Seq_HELA_Human1.28216665
88ER_23166858_ChIP-Seq_MCF-7_Human1.28075644
89CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27518013
90TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27509402
91KAP1_22055183_ChIP-Seq_ESCs_Mouse1.27417024
92P53_21459846_ChIP-Seq_SAOS-2_Human1.27199350
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26754391
94CEBPB_22108803_ChIP-Seq_LS180_Human1.26635764
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25852429
96FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25566654
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24221822
98ERG_20517297_ChIP-Seq_VCAP_Human1.21497289
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.21345176
100GF1_26923725_Chip-Seq_HPCs_Mouse1.20449514
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.20415267
102CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20269942
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.19679127
104P300_27268052_Chip-Seq_Bcells_Human1.19623838
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19376104
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18996233
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18959256
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18758951
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18508114
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18508114
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16993231
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.16861446
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16634144
114NANOG_19829295_ChIP-Seq_ESCs_Human1.15686798
115SOX2_19829295_ChIP-Seq_ESCs_Human1.15686798
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.15113747
117NCOR_22424771_ChIP-Seq_293T_Human1.14866398
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.13954567
119FOXH1_21741376_ChIP-Seq_EPCs_Human1.13744619
120P53_22387025_ChIP-Seq_ESCs_Mouse1.13438914
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12941435
122AR_21572438_ChIP-Seq_LNCaP_Human1.12638352
123RUNX2_22187159_ChIP-Seq_PCA_Human1.11804632
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11688453
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.11430306
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.11321275
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10916574
128FOXH1_21741376_ChIP-Seq_ESCs_Human1.10653083
129KLF4_19829295_ChIP-Seq_ESCs_Human1.10575402
130SPI1_26923725_Chip-Seq_HPCs_Mouse1.09143596
131HOXB7_26014856_ChIP-Seq_BT474_Human1.08031786
132TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07698804
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06374729
134P300_18555785_Chip-Seq_ESCs_Mouse1.05859938
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.05245582
136SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05153781
137ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04991785
138JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04256134
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04051723
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04015180
141OCT4_19829295_ChIP-Seq_ESCs_Human1.03922687
142RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03463738
143SMRT_27268052_Chip-Seq_Bcells_Human1.03246499
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03182922
145SALL4_22934838_ChIP-ChIP_CD34+_Human1.03158530
146GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03083991
147MYC_27129775_Chip-Seq_CORNEA_Mouse1.02553584
148TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01907512
149TP53_18474530_ChIP-ChIP_U2OS_Human1.01606825
150SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01552679
151SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01125718
152SMAD4_21799915_ChIP-Seq_A2780_Human1.01047058
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00879746
154E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00765111
155RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00718795
156RNF2_27304074_Chip-Seq_NSC_Mouse0.99385660
157CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99358930
158NFYB_21822215_ChIP-Seq_K562_Human0.98993668
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98496708
160CTCF_21964334_Chip-Seq_Bcells_Human0.98229871
161SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97997186
162SA1_27219007_Chip-Seq_Bcells_Human0.97911247
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97442185
164P300_19829295_ChIP-Seq_ESCs_Human0.97269568
165TBL1_22424771_ChIP-Seq_293T_Human0.97033297
166SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96997123
167KLF4_18555785_Chip-Seq_ESCs_Mouse0.96797197
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.96229308
169PU1_27457419_Chip-Seq_LIVER_Mouse0.95886439
170KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95760496
171MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95596584
172SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95180915
173LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94260707
174ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94245416
175ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93978398
176FUS_26573619_Chip-Seq_HEK293_Human0.93661282
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92493910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.34253072
2MP0003698_abnormal_male_reproductive5.55338941
3MP0001929_abnormal_gametogenesis4.94578185
4MP0003718_maternal_effect3.64170693
5MP0008877_abnormal_DNA_methylation3.61036637
6MP0005670_abnormal_white_adipose3.04294115
7MP0002210_abnormal_sex_determination2.95678617
8MP0002161_abnormal_fertility/fecundity2.95429767
9MP0001348_abnormal_lacrimal_gland2.71594870
10MP0005174_abnormal_tail_pigmentation2.54264051
11MP0001145_abnormal_male_reproductive2.44839507
12MP0005423_abnormal_somatic_nervous2.30577666
13MP0000678_abnormal_parathyroid_gland2.27750269
14MP0000015_abnormal_ear_pigmentation2.26698220
15MP0005451_abnormal_body_composition2.10890213
16MP0000653_abnormal_sex_gland2.09451248
17MP0005410_abnormal_fertilization15.1463723
18MP0005379_endocrine/exocrine_gland_phen1.85864312
19MP0005083_abnormal_biliary_tract1.79134529
20MP0006292_abnormal_olfactory_placode1.71336588
21MP0002127_abnormal_cardiovascular_syste1.63603781
22MP0005395_other_phenotype1.62658516
23MP0003879_abnormal_hair_cell1.59170712
24MP0002132_abnormal_respiratory_system1.53715117
25MP0006276_abnormal_autonomic_nervous1.46870934
26MP0002138_abnormal_hepatobiliary_system1.43009744
27MP0002653_abnormal_ependyma_morphology1.39191827
28MP0005310_abnormal_salivary_gland1.38307665
29MP0003646_muscle_fatigue1.37142512
30MP0001485_abnormal_pinna_reflex1.34285526
31MP0002249_abnormal_larynx_morphology1.24155424
32MP0005623_abnormal_meninges_morphology1.21512009
33MP0005360_urolithiasis1.19860105
34MP0002160_abnormal_reproductive_system1.19448048
35MP0009053_abnormal_anal_canal1.14655251
36MP0001765_abnormal_ion_homeostasis1.11790323
37MP0001984_abnormal_olfaction1.11436656
38MP0002295_abnormal_pulmonary_circulatio1.07558387
39MP0009840_abnormal_foam_cell1.02601615
40MP0004859_abnormal_synaptic_plasticity1.02223125
41MP0004233_abnormal_muscle_weight1.01559249
42MP0001986_abnormal_taste_sensitivity1.00369814
43MP0002282_abnormal_trachea_morphology0.99447539
44MP0005647_abnormal_sex_gland0.98926807
45MP0003077_abnormal_cell_cycle0.97604033
46MP0005394_taste/olfaction_phenotype0.95821034
47MP0005499_abnormal_olfactory_system0.95821034
48MP0002822_catalepsy0.93837428
49MP0002229_neurodegeneration0.93316847
50MP0005058_abnormal_lysosome_morphology0.93276987
51MP0002735_abnormal_chemical_nociception0.92921435
52MP0000026_abnormal_inner_ear0.91995569
53MP0003950_abnormal_plasma_membrane0.89817117
54MP0001666_abnormal_nutrient_absorption0.87162253
55MP0001881_abnormal_mammary_gland0.85643020
56MP0001324_abnormal_eye_pigmentation0.83210188
57MP0004510_myositis0.82425037
58MP0009046_muscle_twitch0.80528664
59MP0010307_abnormal_tumor_latency0.79934515
60MP0000049_abnormal_middle_ear0.79879681
61MP0008995_early_reproductive_senescence0.79757484
62MP0002067_abnormal_sensory_capabilities0.76414249
63MP0009379_abnormal_foot_pigmentation0.75844358
64MP0003787_abnormal_imprinting0.74539507
65MP0008789_abnormal_olfactory_epithelium0.73836648
66MP0005646_abnormal_pituitary_gland0.71152058
67MP0000534_abnormal_ureter_morphology0.70659618
68MP0002736_abnormal_nociception_after0.70548057
69MP0005377_hearing/vestibular/ear_phenot0.70174617
70MP0003878_abnormal_ear_physiology0.70174617
71MP0000358_abnormal_cell_content/0.68649616
72MP0004142_abnormal_muscle_tone0.68267277
73MP0003283_abnormal_digestive_organ0.67244004
74MP0005645_abnormal_hypothalamus_physiol0.65210630
75MP0003880_abnormal_central_pattern0.64461440
76MP0002733_abnormal_thermal_nociception0.64265344
77MP0005636_abnormal_mineral_homeostasis0.62563202
78MP0002254_reproductive_system_inflammat0.61153801
79MP0000681_abnormal_thyroid_gland0.61026008
80MP0003045_fibrosis0.60031666
81MP0002572_abnormal_emotion/affect_behav0.58784053
82MP0001905_abnormal_dopamine_level0.58783757
83MP0004085_abnormal_heartbeat0.58213588
84MP0000955_abnormal_spinal_cord0.57963172
85MP0008569_lethality_at_weaning0.57882657
86MP0002234_abnormal_pharynx_morphology0.57833817
87MP0003191_abnormal_cellular_cholesterol0.57125577
88MP0001661_extended_life_span0.56909712
89MP0003300_gastrointestinal_ulcer0.56853848
90MP0000230_abnormal_systemic_arterial0.54821975
91MP0005389_reproductive_system_phenotype0.54644549
92MP0004957_abnormal_blastocyst_morpholog0.54215985
93MP0003936_abnormal_reproductive_system0.53850604
94MP0004782_abnormal_surfactant_physiolog0.53379650
95MP0005666_abnormal_adipose_tissue0.52083391
96MP0003693_abnormal_embryo_hatching0.51344895
97MP0001727_abnormal_embryo_implantation0.50763496
98MP0002095_abnormal_skin_pigmentation0.49571497
99MP0005248_abnormal_Harderian_gland0.49462382
100MP0001502_abnormal_circadian_rhythm0.48666628
101MP0009745_abnormal_behavioral_response0.48386051
102MP0001501_abnormal_sleep_pattern0.47872724
103MP0005367_renal/urinary_system_phenotyp0.47019161
104MP0000516_abnormal_urinary_system0.47019161
105MP0004264_abnormal_extraembryonic_tissu0.45702502
106MP0004043_abnormal_pH_regulation0.45476189
107MP0000371_diluted_coat_color0.45371789
108MP0008058_abnormal_DNA_repair0.43838732
109MP0003115_abnormal_respiratory_system0.41620224
110MP0001968_abnormal_touch/_nociception0.40807073
111MP0003329_amyloid_beta_deposits0.39649283
112MP0004036_abnormal_muscle_relaxation0.38417654
113MP0004808_abnormal_hematopoietic_stem0.38141679
114MP0001293_anophthalmia0.37389718
115MP0005253_abnormal_eye_physiology0.37165475
116MP0005464_abnormal_platelet_physiology0.35921813
117MP0000751_myopathy0.35802753
118MP0003385_abnormal_body_wall0.34825948
119MP0009697_abnormal_copulation0.34765271
120MP0003011_delayed_dark_adaptation0.32527692
121MP0001764_abnormal_homeostasis0.30842221
122MP0003699_abnormal_female_reproductive0.30176785
123MP0004811_abnormal_neuron_physiology0.29719496
124MP0005319_abnormal_enzyme/_coenzyme0.29433092
125MP0003633_abnormal_nervous_system0.28551188
126MP0005397_hematopoietic_system_phenotyp0.28428951
127MP0001545_abnormal_hematopoietic_system0.28428951
128MP0001849_ear_inflammation0.27797542
129MP0009115_abnormal_fat_cell0.26724976
130MP0002269_muscular_atrophy0.26542672
131MP0006036_abnormal_mitochondrial_physio0.25862664
132MP0005551_abnormal_eye_electrophysiolog0.25596154
133MP0000604_amyloidosis0.24662226
134MP0002177_abnormal_outer_ear0.24539669
135MP0009278_abnormal_bone_marrow0.23441174
136MP0002139_abnormal_hepatobiliary_system0.22596418
137MP0006035_abnormal_mitochondrial_morpho0.21774226
138MP0001879_abnormal_lymphatic_vessel0.20962887
139MP0002873_normal_phenotype0.18294197
140MP0002169_no_abnormal_phenotype0.18242694
141MP0003631_nervous_system_phenotype0.17729350
142MP0001440_abnormal_grooming_behavior0.17588809
143MP0001119_abnormal_female_reproductive0.17492978
144MP0002557_abnormal_social/conspecific_i0.17084512
145MP0002118_abnormal_lipid_homeostasis0.16296702
146MP0005391_vision/eye_phenotype0.15285375
147MP0010329_abnormal_lipoprotein_level0.15186891
148MP0002971_abnormal_brown_adipose0.15020248
149MP0004019_abnormal_vitamin_homeostasis0.14775720
150MP0009764_decreased_sensitivity_to0.14314487
151MP0000579_abnormal_nail_morphology0.14140815
152MP0005365_abnormal_bile_salt0.14092112
153MP0002063_abnormal_learning/memory/cond0.13040986
154MP0002109_abnormal_limb_morphology0.12972301
155MP0002168_other_aberrant_phenotype0.12923797
156MP0008875_abnormal_xenobiotic_pharmacok0.12863497
157MP0004742_abnormal_vestibular_system0.12575829
158MP0001963_abnormal_hearing_physiology0.12380005
159MP0000462_abnormal_digestive_system0.12094646
160MP0002272_abnormal_nervous_system0.11839906
161MP0003959_abnormal_lean_body0.11688654
162MP0001486_abnormal_startle_reflex0.11334778

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.13853875
2Abnormal respiratory motile cilium morphology (HP:0005938)9.12655076
3Abnormal respiratory epithelium morphology (HP:0012253)9.12655076
4Abnormal ciliary motility (HP:0012262)7.31329068
5Severe visual impairment (HP:0001141)7.27568435
6Rhinitis (HP:0012384)7.08466771
7Chronic bronchitis (HP:0004469)6.93780678
8Infertility (HP:0000789)6.92883349
9Nasal polyposis (HP:0100582)6.13758086
10Bony spicule pigmentary retinopathy (HP:0007737)5.23526046
11Abnormality of the nasal mucosa (HP:0000433)5.07859392
12Male infertility (HP:0003251)4.95550730
13Cone-rod dystrophy (HP:0000548)4.58324320
14Abnormality of macular pigmentation (HP:0008002)4.25069346
15Bronchitis (HP:0012387)4.23251151
16Bronchiectasis (HP:0002110)4.19784441
17J-shaped sella turcica (HP:0002680)4.06911007
18Chronic hepatic failure (HP:0100626)4.06650948
19Dyschromatopsia (HP:0007641)4.03532930
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.95676265
21Resting tremor (HP:0002322)3.86987297
22Abnormal spermatogenesis (HP:0008669)3.78506127
23Abnormal rod and cone electroretinograms (HP:0008323)3.77168293
24Hyperkalemia (HP:0002153)3.68055552
25Nephronophthisis (HP:0000090)3.53313200
26Progressive sensorineural hearing impairment (HP:0000408)3.39609459
27Potter facies (HP:0002009)3.23238771
28Facial shape deformation (HP:0011334)3.23238771
29Recurrent sinusitis (HP:0011108)3.20412732
30Myokymia (HP:0002411)3.19100773
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.07203177
32Tubulointerstitial nephritis (HP:0001970)3.01337162
33Recurrent otitis media (HP:0000403)3.01134151
34Enlarged epiphyses (HP:0010580)2.99558325
35Malnutrition (HP:0004395)2.94845045
36Deformed sella turcica (HP:0002681)2.92065234
37Anterior segment dysgenesis (HP:0007700)2.83563588
38Albinism (HP:0001022)2.81215063
39Amelogenesis imperfecta (HP:0000705)2.80946132
40Progressive cerebellar ataxia (HP:0002073)2.79172627
41Truncal obesity (HP:0001956)2.78147581
42Postural instability (HP:0002172)2.72673466
43Progressive hearing impairment (HP:0001730)2.70020207
44Abnormality of dental color (HP:0011073)2.66255509
45Generalized aminoaciduria (HP:0002909)2.65305930
46Abnormality of the renal medulla (HP:0100957)2.62277687
47Hypoplastic ischia (HP:0003175)2.61547097
48Hypophosphatemic rickets (HP:0004912)2.60364070
49Hypoalphalipoproteinemia (HP:0003233)2.59274342
50Hypoplasia of the thymus (HP:0000778)2.58798593
51Abnormality of the aortic arch (HP:0012303)2.52736204
52Constricted visual fields (HP:0001133)2.49005779
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.48335145
54Hypoplasia of the fovea (HP:0007750)2.48335145
55Decreased central vision (HP:0007663)2.46538122
56Recurrent bronchitis (HP:0002837)2.42898133
57Tubulointerstitial abnormality (HP:0001969)2.41273534
58Azoospermia (HP:0000027)2.39127656
59Osteomalacia (HP:0002749)2.38890994
60Insulin-resistant diabetes mellitus (HP:0000831)2.33432120
61Impulsivity (HP:0100710)2.32957272
62Abnormality of the ischium (HP:0003174)2.30946839
63Abnormal gallbladder physiology (HP:0012438)2.27154600
64Cholecystitis (HP:0001082)2.27154600
65Pendular nystagmus (HP:0012043)2.25150914
66Tubular atrophy (HP:0000092)2.22099685
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20350423
68Hypergonadotropic hypogonadism (HP:0000815)2.19172883
69Congenital sensorineural hearing impairment (HP:0008527)2.16075019
70Abnormality of the costochondral junction (HP:0000919)2.15860949
71Menstrual irregularities (HP:0000858)2.15035578
72Abnormality of potassium homeostasis (HP:0011042)2.14675060
73Portal hypertension (HP:0001409)2.12841478
74Horizontal nystagmus (HP:0000666)2.12033018
75Abnormality of the sella turcica (HP:0002679)2.10226898
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01604777
77Bell-shaped thorax (HP:0001591)2.00324512
78Absent/shortened dynein arms (HP:0200106)13.3901558
79Dynein arm defect of respiratory motile cilia (HP:0012255)13.3901558
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3191638
81Molar tooth sign on MRI (HP:0002419)1.99197458
82Abnormality of midbrain morphology (HP:0002418)1.99197458
83Renovascular hypertension (HP:0100817)1.98959200
84Photophobia (HP:0000613)1.97317840
85Muscle fiber atrophy (HP:0100295)1.95190846
86Bradycardia (HP:0001662)1.95009162
87Type 2 muscle fiber atrophy (HP:0003554)1.94004869
88Premature ovarian failure (HP:0008209)1.93970249
89Macular degeneration (HP:0000608)1.93874798
90Abnormality of the hepatic vasculature (HP:0006707)1.93708455
91Polyuria (HP:0000103)1.93276102
92Unilateral renal agenesis (HP:0000122)1.90533874
93Asymmetric septal hypertrophy (HP:0001670)1.90052223
94Choroideremia (HP:0001139)1.88369488
95Gonadotropin excess (HP:0000837)1.87750659
96Abnormality of the pubic bones (HP:0003172)1.87433549
97Medial flaring of the eyebrow (HP:0010747)1.86546193
98Abnormality of the fovea (HP:0000493)1.86164059
99Renal dysplasia (HP:0000110)1.85748875
100Scotoma (HP:0000575)1.84675845
101Hemorrhage of the eye (HP:0011885)1.84482110
102Central scotoma (HP:0000603)1.83207087
103Glossoptosis (HP:0000162)1.82290722
104Optic nerve hypoplasia (HP:0000609)1.81959732
105Renal Fanconi syndrome (HP:0001994)1.81932695
106Tubulointerstitial fibrosis (HP:0005576)1.81226003
107Subcapsular cataract (HP:0000523)1.72615496
108Upper limb muscle weakness (HP:0003484)1.71546290
109Preauricular pit (HP:0004467)1.70380133
110Periauricular skin pits (HP:0100277)1.70380133
111Spastic tetraparesis (HP:0001285)1.67983507
112Postaxial foot polydactyly (HP:0001830)1.67008784
113Stage 5 chronic kidney disease (HP:0003774)1.58886686
114Heterotopia (HP:0002282)1.56205901
115Attenuation of retinal blood vessels (HP:0007843)1.55817759
116Abnormality of renal excretion (HP:0011036)1.54077002
117Beaking of vertebral bodies (HP:0004568)1.52732626
118Congenital hepatic fibrosis (HP:0002612)1.52731879
119Hemiparesis (HP:0001269)1.52604732
120Abnormal drinking behavior (HP:0030082)1.52175313
121Polydipsia (HP:0001959)1.52175313
122Abnormality of the renal cortex (HP:0011035)1.52145990
123Double outlet right ventricle (HP:0001719)1.51345485
124Congenital malformation of the right heart (HP:0011723)1.51345485
125Neurodegeneration (HP:0002180)1.50222134
126Abnormality of permanent molar morphology (HP:0011071)1.44423894
127Abnormality of the dental root (HP:0006486)1.44423894
128Taurodontia (HP:0000679)1.44423894
129Short ribs (HP:0000773)1.44112078
130Abnormality of molar morphology (HP:0011070)1.40999297
131Abnormality of molar (HP:0011077)1.40999297
132Retinal dysplasia (HP:0007973)1.40796880
133Neurofibrillary tangles (HP:0002185)1.39769819
134Bile duct proliferation (HP:0001408)1.39211579
135Abnormal biliary tract physiology (HP:0012439)1.39211579
136Abnormality of the lumbar spine (HP:0100712)1.36720655
137Neoplasm of the heart (HP:0100544)1.36305480
138Absent rod-and cone-mediated responses on ERG (HP:0007688)1.34050281
139Vascular calcification (HP:0004934)1.33542844
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.33516590
141Exercise-induced myalgia (HP:0003738)1.33136566
142Abnormality of the dental pulp (HP:0006479)1.33088220
143Facial cleft (HP:0002006)1.30226309
144Bundle branch block (HP:0011710)1.29863914
145Abnormality of the neuromuscular junction (HP:0003398)1.29753642
146Fatigable weakness (HP:0003473)1.29753642
147Optic neuritis (HP:0100653)1.28850605
148Retrobulbar optic neuritis (HP:0100654)1.28850605
149Sensory axonal neuropathy (HP:0003390)1.27687875
150Joint hemorrhage (HP:0005261)1.27502153
151Thoracic kyphosis (HP:0002942)1.27096512
152Easy fatigability (HP:0003388)1.26532815
153Broad distal phalanx of finger (HP:0009836)1.25592783
154Abnormality of dentin (HP:0010299)1.23040700
155Urinary glycosaminoglycan excretion (HP:0003541)1.22546484
156Mucopolysacchariduria (HP:0008155)1.22546484
157Nephropathy (HP:0000112)1.21371556
158Aplasia/Hypoplasia of the lens (HP:0008063)1.20974371
159Cardiovascular calcification (HP:0011915)1.20803657
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19063986
161Abnormal urine output (HP:0012590)1.17126693
162Postaxial hand polydactyly (HP:0001162)1.16260377
163Short thorax (HP:0010306)1.16000080
164Hypoplasia of the capital femoral epiphysis (HP:0003090)1.15993466
165Oculomotor apraxia (HP:0000657)1.12626544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.99018457
2PDK47.99018457
3TESK15.71613490
4PDK25.12309005
5PRKD34.79175585
6ICK4.22526027
7INSRR3.86487765
8PLK23.30823330
9BRD43.07317448
10MAP4K22.60796722
11WNK42.32820716
12LATS22.28713310
13NEK62.28696335
14PTK2B2.16691054
15STK392.09639692
16CDK192.05951886
17PIK3CG2.03915352
18BRSK21.90849600
19STK381.71163261
20PNCK1.70237308
21IRAK11.62589539
22CDK71.56748102
23NEK21.53491844
24DYRK1B1.48117113
25BRSK11.44724421
26EPHA31.44138623
27MAP2K71.33413149
28EPHB11.28209364
29MAP3K91.25599731
30MST1R1.18561467
31CDK121.16012714
32BUB11.15192738
33MAP3K41.13521573
34STK31.12085703
35LMTK21.11135882
36PDK11.10972321
37RIPK41.10739357
38STK161.09464022
39SRPK11.04427993
40ADRBK21.02516059
41TRIM281.01096092
42PINK10.87454889
43WNK10.84608789
44ZAK0.83575864
45CAMK1G0.80370987
46MAPK150.72722419
47NTRK30.71331979
48DDR20.68965460
49MARK30.67405528
50TLK10.67324416
51BMPR1B0.66436380
52TYRO30.64444240
53PDPK10.61564374
54PRKG20.59963839
55BRAF0.59361787
56DYRK30.59125634
57NME10.57216365
58MAP2K60.56549358
59FGFR40.56147237
60IRAK20.56110558
61CAMK1D0.54932862
62ACVR1B0.53937817
63CDK20.53015711
64CDC70.51873618
65PAK60.50671252
66MAP2K40.49819035
67RPS6KA10.49532851
68NTRK20.46909409
69PASK0.44027787
70TIE10.42961649
71AURKA0.41948316
72PRKAA20.41180097
73MAP3K80.41012443
74MAPK10.40967387
75UHMK10.40476514
76CLK10.40167453
77MAPK110.40147544
78ARAF0.37166832
79PAK10.36546468
80TTK0.35394416
81RPS6KA20.34647766
82PRKCQ0.34489369
83STK38L0.34347170
84OXSR10.32818627
85AKT30.32578235
86CCNB10.31243135
87MUSK0.30511218
88PLK40.29795029
89CAMKK10.29444646
90MAP3K110.29432734
91PRKCG0.29177883
92CDK30.28961712
93KSR20.28863099
94CHEK20.28455438
95KIT0.27430161
96MAP2K20.26579412
97MAP3K10.26549331
98FRK0.26479847
99EEF2K0.25617361
100TAOK30.25527261
101SIK20.24973863
102NLK0.24504374
103PRKAA10.24139296
104PRKCE0.23403133
105ROCK10.23030165
106CHEK10.23000486
107LATS10.22449001
108RPS6KL10.21223108
109RPS6KC10.21223108
110PRKCZ0.20642070
111CSNK1E0.20595400
112RPS6KA60.19752462
113MAPKAPK50.19626470
114FER0.18845628
115MAP3K100.18636306
116MAPK140.18575528
117ALK0.17486571
118ATM0.16012057
119SGK10.14915033
120PRKACG0.14471318
121PRKCD0.13959313
122MAPK90.13909340
123TESK20.13651992
124MAPK100.13295249
125PAK20.13293500
126CDK150.13258045
127TNK20.13119009
128CAMK40.12976156
129EIF2AK30.12523840
130CAMK10.12496836
131CSNK2A20.12405885
132AKT10.11740237
133ATR0.10858082
134PRKG10.10658217
135CDK11A0.10621603
136PKN10.09859351
137CDK180.09747251
138GSK3A0.09694438
139MTOR0.08401298
140PAK30.07621695
141YES10.07180190
142TNIK0.07158137
143PLK10.06799189
144PRKCA0.06415194
145DYRK20.05914177
146CAMK2A0.05859214
147GSK3B0.05056397
148HCK0.04187019
149CSK0.04173215
150PRKCB0.03809446
151JAK10.03525904
152MAPK80.03454041
153CDK10.03215099
154CDK140.02870772
155FES0.02379773
156AURKB0.02195660
157MARK20.01791786
158ERBB40.01504841
159BMX0.01465885
160RPS6KB10.01292453
161CSNK2A10.01288974

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.29685832
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.26252923
3Olfactory transduction_Homo sapiens_hsa047404.25292023
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.64313104
5Vitamin B6 metabolism_Homo sapiens_hsa007503.63195680
6Pyruvate metabolism_Homo sapiens_hsa006203.41592000
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.12686384
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.93457663
9Linoleic acid metabolism_Homo sapiens_hsa005912.89015566
10RNA transport_Homo sapiens_hsa030132.60755432
11Glucagon signaling pathway_Homo sapiens_hsa049222.35177486
12Propanoate metabolism_Homo sapiens_hsa006402.32866676
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.23714937
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08249369
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.01144982
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85065622
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83375912
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83065375
19Fructose and mannose metabolism_Homo sapiens_hsa000511.78691463
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73785277
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73315187
22PPAR signaling pathway_Homo sapiens_hsa033201.73042103
23Butanoate metabolism_Homo sapiens_hsa006501.72339634
24Glycerolipid metabolism_Homo sapiens_hsa005611.65649744
25Dorso-ventral axis formation_Homo sapiens_hsa043201.61150404
26Mineral absorption_Homo sapiens_hsa049781.56937880
27RNA polymerase_Homo sapiens_hsa030201.53754675
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.48858460
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48252528
30Selenocompound metabolism_Homo sapiens_hsa004501.42574070
31Amphetamine addiction_Homo sapiens_hsa050311.39246260
32Ether lipid metabolism_Homo sapiens_hsa005651.38203978
33Cardiac muscle contraction_Homo sapiens_hsa042601.38044438
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34686017
35Oocyte meiosis_Homo sapiens_hsa041141.34141730
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32873061
37Allograft rejection_Homo sapiens_hsa053301.31974798
38Autoimmune thyroid disease_Homo sapiens_hsa053201.30172875
39Type I diabetes mellitus_Homo sapiens_hsa049401.29711900
40Fatty acid degradation_Homo sapiens_hsa000711.27967770
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26640989
42Basal transcription factors_Homo sapiens_hsa030221.24823774
43Graft-versus-host disease_Homo sapiens_hsa053321.24758522
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21010610
45Histidine metabolism_Homo sapiens_hsa003401.17233445
46Folate biosynthesis_Homo sapiens_hsa007901.16900906
47Carbon metabolism_Homo sapiens_hsa012001.13916394
48Bile secretion_Homo sapiens_hsa049761.12824535
49Fat digestion and absorption_Homo sapiens_hsa049751.12276252
50Morphine addiction_Homo sapiens_hsa050321.11707907
51Fatty acid metabolism_Homo sapiens_hsa012121.09228551
52Pentose phosphate pathway_Homo sapiens_hsa000301.04974958
53Insulin secretion_Homo sapiens_hsa049111.04111438
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03359407
55Phenylalanine metabolism_Homo sapiens_hsa003601.00864685
56Arachidonic acid metabolism_Homo sapiens_hsa005901.00798689
57Serotonergic synapse_Homo sapiens_hsa047261.00042193
58Regulation of autophagy_Homo sapiens_hsa041400.99266740
59Fanconi anemia pathway_Homo sapiens_hsa034600.98038147
60Phototransduction_Homo sapiens_hsa047440.96410709
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95377123
62Thyroid hormone synthesis_Homo sapiens_hsa049180.95269901
63Cell cycle_Homo sapiens_hsa041100.93598243
64Long-term potentiation_Homo sapiens_hsa047200.93412703
65Renin secretion_Homo sapiens_hsa049240.92867601
66Ribosome_Homo sapiens_hsa030100.88968598
67Chemical carcinogenesis_Homo sapiens_hsa052040.88741607
68Protein digestion and absorption_Homo sapiens_hsa049740.87088813
69mRNA surveillance pathway_Homo sapiens_hsa030150.86666504
70Type II diabetes mellitus_Homo sapiens_hsa049300.85961017
71Collecting duct acid secretion_Homo sapiens_hsa049660.83547477
72Glutathione metabolism_Homo sapiens_hsa004800.82836106
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.79385386
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.79322138
75Influenza A_Homo sapiens_hsa051640.78175003
76Huntingtons disease_Homo sapiens_hsa050160.77891620
77Viral myocarditis_Homo sapiens_hsa054160.76728264
78Starch and sucrose metabolism_Homo sapiens_hsa005000.73652470
79Spliceosome_Homo sapiens_hsa030400.73599228
80Salivary secretion_Homo sapiens_hsa049700.72740472
81beta-Alanine metabolism_Homo sapiens_hsa004100.71819139
82Purine metabolism_Homo sapiens_hsa002300.69184086
83Nicotine addiction_Homo sapiens_hsa050330.68526716
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.67601118
85Estrogen signaling pathway_Homo sapiens_hsa049150.66105339
86Pancreatic secretion_Homo sapiens_hsa049720.65603640
87Antigen processing and presentation_Homo sapiens_hsa046120.65547799
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64127180
89Viral carcinogenesis_Homo sapiens_hsa052030.63100646
90Arginine biosynthesis_Homo sapiens_hsa002200.60305152
91ABC transporters_Homo sapiens_hsa020100.55492873
92Gastric acid secretion_Homo sapiens_hsa049710.54534452
93Arginine and proline metabolism_Homo sapiens_hsa003300.52273066
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51706519
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.49720211
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.47516848
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47309991
98Hedgehog signaling pathway_Homo sapiens_hsa043400.46995042
99Biosynthesis of amino acids_Homo sapiens_hsa012300.46582918
100Herpes simplex infection_Homo sapiens_hsa051680.46575914
101Calcium signaling pathway_Homo sapiens_hsa040200.46336604
102Pyrimidine metabolism_Homo sapiens_hsa002400.45548470
103Epstein-Barr virus infection_Homo sapiens_hsa051690.45508180
104Renin-angiotensin system_Homo sapiens_hsa046140.45071277
105Base excision repair_Homo sapiens_hsa034100.44496678
106Complement and coagulation cascades_Homo sapiens_hsa046100.43416938
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40339434
108GABAergic synapse_Homo sapiens_hsa047270.39838215
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.37827036
110Acute myeloid leukemia_Homo sapiens_hsa052210.37595797
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.37457234
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37193196
113Synaptic vesicle cycle_Homo sapiens_hsa047210.36115163
114Tyrosine metabolism_Homo sapiens_hsa003500.35739813
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35650010
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35487121
117Metabolic pathways_Homo sapiens_hsa011000.35045750
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32728310
119VEGF signaling pathway_Homo sapiens_hsa043700.32177694
120cAMP signaling pathway_Homo sapiens_hsa040240.31863327
121Oxytocin signaling pathway_Homo sapiens_hsa049210.31676559
122Legionellosis_Homo sapiens_hsa051340.31259982
123MAPK signaling pathway_Homo sapiens_hsa040100.29483920
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.29368695
125Cholinergic synapse_Homo sapiens_hsa047250.29071824
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28090199
127Endocytosis_Homo sapiens_hsa041440.26356843
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.26269506
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24930236
130Cocaine addiction_Homo sapiens_hsa050300.24394377
131Glutamatergic synapse_Homo sapiens_hsa047240.23976497
132Retinol metabolism_Homo sapiens_hsa008300.23504285
133Taste transduction_Homo sapiens_hsa047420.22696337
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21331239
135Sphingolipid metabolism_Homo sapiens_hsa006000.20852424
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20680235
137Inositol phosphate metabolism_Homo sapiens_hsa005620.20279266
138Sulfur metabolism_Homo sapiens_hsa009200.19987453
139Systemic lupus erythematosus_Homo sapiens_hsa053220.18901913
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18456896
141Ovarian steroidogenesis_Homo sapiens_hsa049130.18336575
142Circadian entrainment_Homo sapiens_hsa047130.17680787
143Vitamin digestion and absorption_Homo sapiens_hsa049770.17671219

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