PRSS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.12476320
2urate metabolic process (GO:0046415)7.56850445
3drug transmembrane transport (GO:0006855)7.42109826
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.05516863
5lysine catabolic process (GO:0006554)6.85889942
6lysine metabolic process (GO:0006553)6.85889942
7cysteine metabolic process (GO:0006534)6.71677050
8drug transport (GO:0015893)6.57705328
9aminoglycoside antibiotic metabolic process (GO:0030647)6.46865912
10phosphate ion transport (GO:0006817)6.29786263
11organic cation transport (GO:0015695)6.02459872
12phosphate ion transmembrane transport (GO:0035435)5.59993669
13glyoxylate metabolic process (GO:0046487)5.31965078
14angiotensin maturation (GO:0002003)5.30201277
15excretion (GO:0007588)5.19801015
16regulation of water loss via skin (GO:0033561)5.14476039
17response to mercury ion (GO:0046689)5.07021482
18branched-chain amino acid metabolic process (GO:0009081)5.04609474
19intestinal absorption (GO:0050892)5.04032706
20NADH metabolic process (GO:0006734)5.00635438
21valine metabolic process (GO:0006573)4.98511635
22aspartate family amino acid catabolic process (GO:0009068)4.95963142
23homocysteine metabolic process (GO:0050667)4.94904883
24renal absorption (GO:0070293)4.93829505
25peptide catabolic process (GO:0043171)4.88666066
26regulation of guanylate cyclase activity (GO:0031282)4.86037839
27surfactant homeostasis (GO:0043129)4.81419948
28quaternary ammonium group transport (GO:0015697)4.80056187
29proline metabolic process (GO:0006560)4.75814279
30drug catabolic process (GO:0042737)4.69391263
31multicellular organismal water homeostasis (GO:0050891)4.65391012
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.64709955
33establishment of skin barrier (GO:0061436)4.60442318
34nonribosomal peptide biosynthetic process (GO:0019184)4.58883255
35branched-chain amino acid catabolic process (GO:0009083)4.56831210
36cellular modified amino acid catabolic process (GO:0042219)4.54957517
37short-chain fatty acid metabolic process (GO:0046459)4.52284845
38serine family amino acid metabolic process (GO:0009069)4.50564572
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.43555010
40L-phenylalanine metabolic process (GO:0006558)4.43555010
41tricarboxylic acid metabolic process (GO:0072350)4.42580529
42exogenous drug catabolic process (GO:0042738)4.40695255
43positive regulation of Cdc42 GTPase activity (GO:0043089)4.37034187
44serine family amino acid catabolic process (GO:0009071)4.27771228
45trivalent inorganic anion homeostasis (GO:0072506)4.26628619
46phosphate ion homeostasis (GO:0055062)4.26628619
47vitamin D metabolic process (GO:0042359)4.25399581
48modified amino acid transport (GO:0072337)4.23625481
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23355395
50L-phenylalanine catabolic process (GO:0006559)4.23355395
51toxin transport (GO:1901998)4.17412119
52glutathione biosynthetic process (GO:0006750)4.15825850
53regulation of cholesterol homeostasis (GO:2000188)4.15520584
54cobalamin metabolic process (GO:0009235)4.13284638
55calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.12145657
56amino-acid betaine metabolic process (GO:0006577)4.10283439
57GDP-mannose metabolic process (GO:0019673)4.08147279
58epithelial cell-cell adhesion (GO:0090136)4.05909485
59sulfur amino acid catabolic process (GO:0000098)4.03804816
60serine family amino acid biosynthetic process (GO:0009070)4.03556322
61aromatic amino acid family catabolic process (GO:0009074)4.00689091
62metanephric nephron tubule development (GO:0072234)3.99804452
63metanephric tubule development (GO:0072170)3.99804452
64chemical homeostasis within a tissue (GO:0048875)3.94759875
65renal system process involved in regulation of blood volume (GO:0001977)3.93940087
66positive regulation of pseudopodium assembly (GO:0031274)3.90071106
672-oxoglutarate metabolic process (GO:0006103)3.88851222
68regulation of bile acid biosynthetic process (GO:0070857)3.84614990
69protein retention in ER lumen (GO:0006621)3.84561253
70indole-containing compound catabolic process (GO:0042436)3.82477044
71indolalkylamine catabolic process (GO:0046218)3.82477044
72tryptophan catabolic process (GO:0006569)3.82477044
73vitamin transmembrane transport (GO:0035461)3.82316877
74negative regulation of keratinocyte proliferation (GO:0010839)3.80013051
75exocrine pancreas development (GO:0031017)3.75702171
76water homeostasis (GO:0030104)3.73928369
77fatty acid beta-oxidation (GO:0006635)3.73249553
78proline biosynthetic process (GO:0006561)3.71036782
79metanephric nephron epithelium development (GO:0072243)3.71019718
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70808603
81vitamin transport (GO:0051180)3.70151153
82urea cycle (GO:0000050)3.67462376
83glutathione derivative metabolic process (GO:1901685)3.65813234
84glutathione derivative biosynthetic process (GO:1901687)3.65813234
85amino-acid betaine transport (GO:0015838)3.65323810
86carnitine transport (GO:0015879)3.65323810
87carnitine metabolic process (GO:0009437)3.62041383
88epoxygenase P450 pathway (GO:0019373)3.61889780
89gap junction assembly (GO:0016264)3.61520778
90tryptophan metabolic process (GO:0006568)3.60838281
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58391363
92biotin metabolic process (GO:0006768)3.58326914
93fructose metabolic process (GO:0006000)3.54284871
94hemidesmosome assembly (GO:0031581)3.50648028
95regulation of systemic arterial blood pressure by hormone (GO:0001990)3.50018073
96regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.50018073
97endocrine process (GO:0050886)3.50018073
98fatty acid oxidation (GO:0019395)3.48849055
99positive regulation of guanylate cyclase activity (GO:0031284)3.47988054
100cellular amino acid catabolic process (GO:0009063)3.44815764
101tight junction assembly (GO:0070830)3.43463247
102digestion (GO:0007586)3.43002458
103positive regulation of epidermal cell differentiation (GO:0045606)3.40397726
104lipid oxidation (GO:0034440)3.40366937
105urea metabolic process (GO:0019627)3.40355354
106regulation of pseudopodium assembly (GO:0031272)3.38853040
107peptide biosynthetic process (GO:0043043)3.36346606
108transcytosis (GO:0045056)3.34326368
109metanephric epithelium development (GO:0072207)3.33614458
110response to phenylpropanoid (GO:0080184)3.33407206
111acetyl-CoA metabolic process (GO:0006084)3.32137251
112regulation of systemic arterial blood pressure (GO:0003073)3.31217837
1134-hydroxyproline metabolic process (GO:0019471)3.30928396
114maintenance of gastrointestinal epithelium (GO:0030277)3.30925218
115glycoside metabolic process (GO:0016137)3.30756889
116regulation of keratinocyte proliferation (GO:0010837)3.29486437
117trophectodermal cell differentiation (GO:0001829)3.29170296
118branching involved in mammary gland duct morphogenesis (GO:0060444)3.28031057
119kynurenine metabolic process (GO:0070189)3.27057137
120L-ascorbic acid metabolic process (GO:0019852)3.26300018
121nephron tubule development (GO:0072080)3.25843806
122alpha-amino acid catabolic process (GO:1901606)3.24789473
123glutamate metabolic process (GO:0006536)3.22688061
124fat-soluble vitamin biosynthetic process (GO:0042362)3.22346319
125regulation of apoptotic process involved in morphogenesis (GO:1902337)3.21928837
126antimicrobial humoral response (GO:0019730)3.21259031
127fatty acid catabolic process (GO:0009062)3.20450786
128Golgi transport vesicle coating (GO:0048200)3.20212223
129COPI coating of Golgi vesicle (GO:0048205)3.20212223
130glutathione metabolic process (GO:0006749)3.19909893
131nucleotide-sugar biosynthetic process (GO:0009226)3.18493885
132glomerular filtration (GO:0003094)3.17504504
133uronic acid metabolic process (GO:0006063)3.17376309
134glucuronate metabolic process (GO:0019585)3.17376309
135O-glycan processing (GO:0016266)3.17006429
136renal filtration (GO:0097205)3.16593971
137cellular glucuronidation (GO:0052695)3.15427961
138organic acid catabolic process (GO:0016054)3.15143936
139carboxylic acid catabolic process (GO:0046395)3.15143936
140regulation of cellular extravasation (GO:0002691)3.15128993
141positive regulation of respiratory burst (GO:0060267)3.15079234
142sodium-independent organic anion transport (GO:0043252)3.14957908
143sulfur compound transport (GO:0072348)3.13169608
144keratinization (GO:0031424)3.10618366
145antibacterial humoral response (GO:0019731)3.10613003
146regulation of keratinocyte differentiation (GO:0045616)3.10197542
147establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.09881712
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.09544495
149aromatic amino acid family metabolic process (GO:0009072)3.09105382
150flavonoid metabolic process (GO:0009812)3.07739729
151glutamine family amino acid biosynthetic process (GO:0009084)3.07101259
152polyol transport (GO:0015791)3.05456573
153positive regulation of glycoprotein metabolic process (GO:1903020)3.02826658
154oligosaccharide catabolic process (GO:0009313)3.02771660
155intestinal cholesterol absorption (GO:0030299)3.02183356
156folic acid metabolic process (GO:0046655)3.00639455
157oligosaccharide biosynthetic process (GO:0009312)2.99904038
158cellular ketone body metabolic process (GO:0046950)2.99231707
159monocarboxylic acid catabolic process (GO:0072329)2.98848800
160intestinal epithelial cell development (GO:0060576)2.98779970
161regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.98050718
162very-low-density lipoprotein particle assembly (GO:0034379)2.96045400
163sphingomyelin metabolic process (GO:0006684)2.95560866
164nitrogen cycle metabolic process (GO:0071941)2.94020645
165regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.93431198
166regulation of cGMP biosynthetic process (GO:0030826)2.88361253
167diacylglycerol metabolic process (GO:0046339)2.86677053
168branching involved in labyrinthine layer morphogenesis (GO:0060670)2.83706779
169positive regulation of keratinocyte differentiation (GO:0045618)2.83469048
170regulation of transforming growth factor beta1 production (GO:0032908)2.82381695
171renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.80737146
172cell-cell junction assembly (GO:0007043)2.79101258
173response to food (GO:0032094)2.78648923
174epithelial structure maintenance (GO:0010669)2.75959307
175positive regulation of glycoprotein biosynthetic process (GO:0010560)2.75757255
176ethanol metabolic process (GO:0006067)2.74731639
177phospholipid efflux (GO:0033700)2.74714098
178negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.73211447
179bile acid and bile salt transport (GO:0015721)2.70970354
180ventricular cardiac muscle cell action potential (GO:0086005)2.70889609
181drug metabolic process (GO:0017144)2.70748597
182glucose 6-phosphate metabolic process (GO:0051156)2.70377376
183hormone catabolic process (GO:0042447)2.70056868
184negative regulation of cell fate specification (GO:0009996)2.69562571
185plasma lipoprotein particle assembly (GO:0034377)2.68634615
186receptor guanylyl cyclase signaling pathway (GO:0007168)2.68087409
187primary alcohol catabolic process (GO:0034310)2.67993812
188polarized epithelial cell differentiation (GO:0030859)2.67138734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.22046856
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.86571700
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.81194123
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.04083390
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88607689
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.76689337
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.76617049
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.46531018
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.05714676
10ESR2_21235772_ChIP-Seq_MCF-7_Human3.02604538
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.70639594
12* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.52630610
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.51881231
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50202054
15* GATA4_25053715_ChIP-Seq_YYC3_Human2.45907728
16AR_21909140_ChIP-Seq_LNCAP_Human2.38582785
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.36530613
18CLOCK_20551151_ChIP-Seq_293T_Human2.20748896
19GATA6_25053715_ChIP-Seq_YYC3_Human2.13720049
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06087773
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94108647
22RACK7_27058665_Chip-Seq_MCF-7_Human1.93683206
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.85019016
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.83924889
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.82128132
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78088622
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71939455
28* SOX2_20726797_ChIP-Seq_SW620_Human1.63609725
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62679463
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.61293135
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60675899
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60076299
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59664365
34ZNF263_19887448_ChIP-Seq_K562_Human1.56258377
35* KLF5_25053715_ChIP-Seq_YYC3_Human1.54598352
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50392744
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49385476
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49027070
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48009115
40* ATF3_27146783_Chip-Seq_COLON_Human1.47365648
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47001212
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46373134
43* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44794594
44* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43991096
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42793848
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36135665
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.36069680
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34085205
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32908928
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32438237
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32359458
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.30531343
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.30438947
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28166936
55SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27941718
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27084119
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26234090
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26234090
59KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26234090
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23496393
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21952466
62* LXR_22292898_ChIP-Seq_THP-1_Human1.20856364
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20076179
64* CTCF_27219007_Chip-Seq_Bcells_Human1.20019944
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18960353
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.18955825
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18735551
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16987582
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16903984
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16430410
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.15358337
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14504625
73SMC4_20622854_ChIP-Seq_HELA_Human1.14219943
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13696079
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13153688
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12548872
77* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11308067
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11148867
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10842722
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10478275
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10249781
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08988124
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08983389
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07595469
85SA1_27219007_Chip-Seq_Bcells_Human1.05657084
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04051607
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04008699
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03628691
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03249092
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02191231
91* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01951147
92* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01917163
93BCOR_27268052_Chip-Seq_Bcells_Human1.01890484
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.01581116
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01331862
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00198795
97P68_20966046_ChIP-Seq_HELA_Human0.99800288
98CHD1_26751641_Chip-Seq_LNCaP_Human0.99183082
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98840870
100OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97714585
101GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96201206
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95528219
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95239909
104KDM2B_26808549_Chip-Seq_K562_Human0.94618122
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94443715
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94278920
107SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93621069
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93574478
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93574478
110* CREB1_26743006_Chip-Seq_LNCaP_Human0.93174733
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93113852
112* NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89726919
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87486234
114TP63_22573176_ChIP-Seq_HFKS_Human0.86581975
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.85625322
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.85625322
117EGR1_19032775_ChIP-ChIP_M12_Human0.84834377
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84366960
119STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84227937
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83280884
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.80618282
122MYC_18555785_ChIP-Seq_MESCs_Mouse0.80057771
123P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79095064
124GATA1_22025678_ChIP-Seq_K562_Human0.79086399
125* SA1_27219007_Chip-Seq_ERYTHROID_Human0.76211102
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.76087227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.60110231
2MP0004043_abnormal_pH_regulation4.51062359
3MP0002139_abnormal_hepatobiliary_system4.03860727
4MP0004019_abnormal_vitamin_homeostasis3.98184156
5MP0005332_abnormal_amino_acid3.86380458
6MP0001666_abnormal_nutrient_absorption3.45785642
7MP0009643_abnormal_urine_homeostasis3.33615790
8MP0005365_abnormal_bile_salt3.27986120
9MP0002138_abnormal_hepatobiliary_system3.24801561
10MP0010234_abnormal_vibrissa_follicle3.19802753
11MP0005083_abnormal_biliary_tract3.16120242
12MP0003195_calcinosis3.02426639
13MP0005085_abnormal_gallbladder_physiolo2.87015205
14MP0001756_abnormal_urination2.80951376
15MP0001765_abnormal_ion_homeostasis2.73026578
16MP0004264_abnormal_extraembryonic_tissu2.63014144
17MP0008875_abnormal_xenobiotic_pharmacok2.62537790
18MP0005377_hearing/vestibular/ear_phenot2.47220835
19MP0003878_abnormal_ear_physiology2.47220835
20MP0009379_abnormal_foot_pigmentation2.34578550
21MP0005636_abnormal_mineral_homeostasis2.33684025
22MP0000579_abnormal_nail_morphology2.29977205
23MP0002136_abnormal_kidney_physiology2.29907342
24MP0001958_emphysema2.18764651
25MP0005220_abnormal_exocrine_pancreas2.15823906
26MP0003252_abnormal_bile_duct1.88791870
27MP0004858_abnormal_nervous_system1.87627471
28MP0003183_abnormal_peptide_metabolism1.85643329
29MP0005409_darkened_coat_color1.84336709
30MP0005084_abnormal_gallbladder_morpholo1.79194914
31MP0003186_abnormal_redox_activity1.70372240
32MP0010155_abnormal_intestine_physiology1.64067002
33MP0003693_abnormal_embryo_hatching1.60435962
34MP0000467_abnormal_esophagus_morphology1.59476690
35MP0003806_abnormal_nucleotide_metabolis1.57955633
36MP0005058_abnormal_lysosome_morphology1.57923305
37MP0004782_abnormal_surfactant_physiolog1.53933128
38* MP0002796_impaired_skin_barrier1.53514503
39MP0008004_abnormal_stomach_pH1.50036257
40MP0003705_abnormal_hypodermis_morpholog1.48901097
41MP0000537_abnormal_urethra_morphology1.43946026
42MP0005451_abnormal_body_composition1.43889658
43MP0000538_abnormal_urinary_bladder1.42191201
44MP0003866_abnormal_defecation1.38519743
45MP0004147_increased_porphyrin_level1.30360239
46MP0005076_abnormal_cell_differentiation1.30278874
47MP0003300_gastrointestinal_ulcer1.29868790
48MP0010678_abnormal_skin_adnexa1.25982267
49MP0000627_abnormal_mammary_gland1.21718307
50MP0003191_abnormal_cellular_cholesterol1.16213291
51MP0001664_abnormal_digestion1.15463622
52* MP0002098_abnormal_vibrissa_morphology1.15342896
53MP0005319_abnormal_enzyme/_coenzyme1.14844926
54MP0004272_abnormal_basement_membrane1.10658356
55* MP0010771_integument_phenotype1.08474444
56MP0001188_hyperpigmentation1.07351834
57MP0004947_skin_inflammation1.06897880
58MP0003941_abnormal_skin_development1.05575931
59MP0008961_abnormal_basal_metabolism1.03974716
60MP0005408_hypopigmentation1.03613412
61MP0003638_abnormal_response/metabolism_1.03237652
62MP0004885_abnormal_endolymph1.02928721
63MP0002135_abnormal_kidney_morphology1.01270847
64MP0010329_abnormal_lipoprotein_level1.00053322
65* MP0005501_abnormal_skin_physiology0.98538147
66MP0005670_abnormal_white_adipose0.96766408
67* MP0002118_abnormal_lipid_homeostasis0.96296515
68MP0005584_abnormal_enzyme/coenzyme_acti0.95794085
69MP0003718_maternal_effect0.93746191
70* MP0009931_abnormal_skin_appearance0.93170389
71MP0000566_synostosis0.93159347
72MP0002168_other_aberrant_phenotype0.92389318
73MP0003868_abnormal_feces_composition0.91967446
74MP0003283_abnormal_digestive_organ0.91619100
75MP0000383_abnormal_hair_follicle0.89898055
76MP0003566_abnormal_cell_adhesion0.89246345
77MP0005023_abnormal_wound_healing0.88105099
78MP0001764_abnormal_homeostasis0.87789657
79MP0004957_abnormal_blastocyst_morpholog0.87139756
80MP0002896_abnormal_bone_mineralization0.84473607
81MP0000427_abnormal_hair_cycle0.84087385
82MP0006036_abnormal_mitochondrial_physio0.82682236
83MP0000678_abnormal_parathyroid_gland0.82668630
84MP0003315_abnormal_perineum_morphology0.81466929
85MP0005166_decreased_susceptibility_to0.79929139
86MP0002876_abnormal_thyroid_physiology0.79402269
87MP0000462_abnormal_digestive_system0.78384875
88MP0003959_abnormal_lean_body0.78381853
89MP0003453_abnormal_keratinocyte_physiol0.77706454
90MP0002928_abnormal_bile_duct0.76815666
91MP0005666_abnormal_adipose_tissue0.73487860
92* MP0001216_abnormal_epidermal_layer0.73078869
93MP0005395_other_phenotype0.72130159
94MP0004381_abnormal_hair_follicle0.71820004
95MP0002089_abnormal_postnatal_growth/wei0.71253194
96MP0000609_abnormal_liver_physiology0.70784737
97MP0010352_gastrointestinal_tract_polyps0.70183503
98MP0002249_abnormal_larynx_morphology0.68715957
99* MP0000377_abnormal_hair_follicle0.67799926
100MP0009672_abnormal_birth_weight0.66298456
101MP0000647_abnormal_sebaceous_gland0.66213838
102MP0003879_abnormal_hair_cell0.66167669
103MP0001485_abnormal_pinna_reflex0.65531452
104MP0000762_abnormal_tongue_morphology0.64985330
105MP0010030_abnormal_orbit_morphology0.64335364
106MP0000230_abnormal_systemic_arterial0.61088975
107MP0000490_abnormal_crypts_of0.59714548
108MP0006054_spinal_hemorrhage0.59487029
109MP0008872_abnormal_physiological_respon0.59475719
110MP0001663_abnormal_digestive_system0.59450024
111MP0005381_digestive/alimentary_phenotyp0.58873555
112MP0003123_paternal_imprinting0.58172441
113MP0005165_increased_susceptibility_to0.58127228
114MP0009642_abnormal_blood_homeostasis0.58043011
115MP0000598_abnormal_liver_morphology0.57744054
116MP0001873_stomach_inflammation0.56895817
117MP0000534_abnormal_ureter_morphology0.56891102
118MP0001849_ear_inflammation0.56478124
119MP0004185_abnormal_adipocyte_glucose0.56082565
120MP0008260_abnormal_autophagy0.55996945
121MP0009053_abnormal_anal_canal0.55662786
122MP0002254_reproductive_system_inflammat0.54930754
123MP0009384_cardiac_valve_regurgitation0.54905761
124MP0002060_abnormal_skin_morphology0.54587031
125MP0001944_abnormal_pancreas_morphology0.52777712
126MP0000470_abnormal_stomach_morphology0.51976081
127MP0000477_abnormal_intestine_morphology0.50310984
128MP0001661_extended_life_span0.50072734
129MP0005275_abnormal_skin_tensile0.45403952
130MP0009840_abnormal_foam_cell0.44823038
131MP0001881_abnormal_mammary_gland0.44802946
132* MP0000367_abnormal_coat/_hair0.43216507

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)7.19888344
2Hyperactive renin-angiotensin system (HP:0000841)6.81593122
3Hypokalemic alkalosis (HP:0001949)6.23577017
4Abnormality of chloride homeostasis (HP:0011422)6.09667495
5Metabolic alkalosis (HP:0200114)6.07526565
6Increased circulating renin level (HP:0000848)6.03877611
7Hypomagnesemia (HP:0002917)5.78387096
8Abnormality of renal excretion (HP:0011036)5.34598582
9Polyuria (HP:0000103)5.31023755
10Renal salt wasting (HP:0000127)5.25972885
11Abnormal urine output (HP:0012590)5.12401383
12Abnormality of magnesium homeostasis (HP:0004921)5.02539160
13Hyperuricemia (HP:0002149)4.99029486
14Increased purine levels (HP:0004368)4.99029486
15Proximal tubulopathy (HP:0000114)4.95172005
16Hyperglycinuria (HP:0003108)4.80572573
17Tetany (HP:0001281)4.59958922
18Hyperaldosteronism (HP:0000859)4.34316830
19Abnormality of purine metabolism (HP:0004352)4.26130681
20Abnormality of renin-angiotensin system (HP:0000847)4.18067338
21Alkalosis (HP:0001948)4.09111245
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05713545
23Abnormal hair laboratory examination (HP:0003328)4.03369417
24Abnormal drinking behavior (HP:0030082)4.02683980
25Polydipsia (HP:0001959)4.02683980
26Abnormality of glycine metabolism (HP:0010895)3.84740420
27Abnormality of serine family amino acid metabolism (HP:0010894)3.84740420
28Ketoacidosis (HP:0001993)3.51184393
29Hypercalciuria (HP:0002150)3.48423859
30Abnormality of nail color (HP:0100643)3.47920396
31Generalized aminoaciduria (HP:0002909)3.38655532
32Decreased circulating renin level (HP:0003351)3.38155306
33Abnormality of urine glucose concentration (HP:0011016)3.28554628
34Glycosuria (HP:0003076)3.28554628
35Flat acetabular roof (HP:0003180)3.22041026
36Curly hair (HP:0002212)3.19984174
37Abnormality of nucleobase metabolism (HP:0010932)3.17941768
38Abdominal distention (HP:0003270)3.15753524
39Hypokalemia (HP:0002900)3.14309760
40Woolly hair (HP:0002224)3.11045113
41Ketosis (HP:0001946)3.09779270
42Plantar hyperkeratosis (HP:0007556)3.02583039
43Tubulointerstitial fibrosis (HP:0005576)2.99842121
44Renal tubular acidosis (HP:0001947)2.96472854
45Alopecia of scalp (HP:0002293)2.93502523
46Hyperglycinemia (HP:0002154)2.92729587
47Fragile nails (HP:0001808)2.87112086
48Abnormality of fatty-acid metabolism (HP:0004359)2.86481135
49Congenital ichthyosiform erythroderma (HP:0007431)2.83921950
50Vascular calcification (HP:0004934)2.79452885
51Palmoplantar hyperkeratosis (HP:0000972)2.78670561
52Dehydration (HP:0001944)2.73226203
53Amelogenesis imperfecta (HP:0000705)2.71338148
54Hyperphosphaturia (HP:0003109)2.70624802
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67609051
56Intrahepatic cholestasis (HP:0001406)2.64931493
57Abnormality of potassium homeostasis (HP:0011042)2.64513550
58Malnutrition (HP:0004395)2.64023500
59Abnormality of small intestinal villus morphology (HP:0011472)2.63259134
60Villous atrophy (HP:0011473)2.63259134
61Hyperammonemia (HP:0001987)2.60810397
62Delayed CNS myelination (HP:0002188)2.60408146
63Vacuolated lymphocytes (HP:0001922)2.57469336
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.57295920
65Palmar hyperkeratosis (HP:0010765)2.56338285
66Delayed epiphyseal ossification (HP:0002663)2.56121001
67Abnormal urine phosphate concentration (HP:0012599)2.55361260
68Nephrocalcinosis (HP:0000121)2.53250506
69Nephrolithiasis (HP:0000787)2.51925585
70Abnormality of proline metabolism (HP:0010907)2.51196760
71Hydroxyprolinuria (HP:0003080)2.51196760
72Tubular atrophy (HP:0000092)2.49311152
73Lip pit (HP:0100267)2.49215231
74Cardiovascular calcification (HP:0011915)2.44814654
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43128277
76Dicarboxylic aciduria (HP:0003215)2.43128277
77Rickets (HP:0002748)2.41049406
78Glomerulosclerosis (HP:0000096)2.40596300
79Widely patent fontanelles and sutures (HP:0004492)2.40348458
80Systemic lupus erythematosus (HP:0002725)2.39489377
81Hyponatremia (HP:0002902)2.39084129
82Hyperparathyroidism (HP:0000843)2.38241029
83Pterygium (HP:0001059)2.37929382
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.36924064
85Focal segmental glomerulosclerosis (HP:0000097)2.35298551
86Abnormality of vitamin B metabolism (HP:0004340)2.33611965
87Wide cranial sutures (HP:0010537)2.32898002
88Bronchomalacia (HP:0002780)2.32525264
89Abnormality of sodium homeostasis (HP:0010931)2.32395420
90Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30743860
91Abnormality of vitamin metabolism (HP:0100508)2.24743776
92Pili torti (HP:0003777)2.23888639
93Hyperphosphatemia (HP:0002905)2.23018020
94Lethargy (HP:0001254)2.21753526
95Facial shape deformation (HP:0011334)2.21681094
96Potter facies (HP:0002009)2.21681094
97Vomiting (HP:0002013)2.20523087
98Advanced eruption of teeth (HP:0006288)2.20358452
99Thin bony cortex (HP:0002753)2.19881293
100Hemorrhage of the eye (HP:0011885)2.17687352
101Metabolic acidosis (HP:0001942)2.17558225
102Hypophosphatemia (HP:0002148)2.17299630
103Abnormality of the gastric mucosa (HP:0004295)2.17229956
104Abnormality of the salivary glands (HP:0010286)2.15328587
105Milia (HP:0001056)2.14788378
106Hypotrichosis (HP:0001006)2.07655110
107Hypotension (HP:0002615)2.05839038
108Chronic diarrhea (HP:0002028)2.04858488
109Abnormal tarsal ossification (HP:0008369)2.04627828
110Subcapsular cataract (HP:0000523)2.00225099
111Tachypnea (HP:0002789)2.00165627
112Megaloblastic anemia (HP:0001889)1.97836582
113Hypobetalipoproteinemia (HP:0003563)1.97574954
114Abnormal pancreas size (HP:0012094)1.97317697
115Abnormal enzyme/coenzyme activity (HP:0012379)1.96977082
116Metaphyseal cupping (HP:0003021)1.96742420
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.95831034
118Sparse eyelashes (HP:0000653)1.95532083
119Abnormality of permanent molar morphology (HP:0011071)1.94453144
120Abnormality of the dental root (HP:0006486)1.94453144
121Taurodontia (HP:0000679)1.94453144
122Methylmalonic aciduria (HP:0012120)1.93584350
123Popliteal pterygium (HP:0009756)1.93488610
124Hypoplasia of the uterus (HP:0000013)1.92896159
125Confusion (HP:0001289)1.92406605
126Adrenal overactivity (HP:0002717)1.92041900
127Abnormality of alkaline phosphatase activity (HP:0004379)1.91354308
128Xanthomatosis (HP:0000991)1.88828432
129Bicornuate uterus (HP:0000813)1.88040966
130Abnormality of renal resorption (HP:0011038)1.87014455
131Glomerulonephritis (HP:0000099)1.86714203
132Nausea (HP:0002018)1.86293320
133Enlarged kidneys (HP:0000105)1.85402821
134Hypoglycemic coma (HP:0001325)1.83132059
135Hypoplasia of dental enamel (HP:0006297)1.83005069
136Interstitial pulmonary disease (HP:0006530)1.82097341
137Ventricular tachycardia (HP:0004756)1.81064512
138Onycholysis (HP:0001806)1.80529768
139Ileus (HP:0002595)1.80468530
140Symptomatic seizures (HP:0011145)1.79960662
141Flattened epiphyses (HP:0003071)1.79520517
142Right ventricular cardiomyopathy (HP:0011663)1.78975576
143Posterior subcapsular cataract (HP:0007787)1.77381592
144Absent eyelashes (HP:0000561)1.77139256
145Axonal loss (HP:0003447)1.76928556
146Abnormality of molar morphology (HP:0011070)1.76815396
147Abnormality of molar (HP:0011077)1.76815396
148Chronic bronchitis (HP:0004469)1.76799165
149Nephritis (HP:0000123)1.76670843
150Abnormality of carpal bone ossification (HP:0006257)1.76536468
151Visceral angiomatosis (HP:0100761)1.76359657
152Chondrocalcinosis (HP:0000934)1.76196415
153Partial duplication of thumb phalanx (HP:0009944)1.76156689
154Abnormality of serum amino acid levels (HP:0003112)1.75574654
155Fat malabsorption (HP:0002630)1.74855923
156Renal tubular dysfunction (HP:0000124)1.74660313
157Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72501444
158Tubulointerstitial abnormality (HP:0001969)1.72372432
159Esophageal varix (HP:0002040)1.69521441
160Reticulocytopenia (HP:0001896)1.67757321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.46928232
2WNK46.33939662
3OXSR15.31004994
4BCKDK4.52575887
5STK393.24621567
6EPHA23.20142429
7MST42.92783662
8STK38L2.73965253
9ERN12.55187357
10ACVR1B2.28853083
11SMG12.09946571
12NEK12.02500200
13LRRK21.84166436
14TRIB31.78049331
15MST1R1.77796822
16MAP2K21.73971385
17FRK1.71072101
18LATS11.61663662
19MAP3K31.60643541
20PDK31.52461094
21PDK41.52461094
22LATS21.42375478
23MAP3K101.40301755
24FER1.37815686
25PIK3CA1.35726724
26PTK61.32642494
27PDK21.30846283
28PAK41.27608533
29NME11.27098924
30RPS6KB21.22047248
31TESK21.21391790
32LMTK21.18822586
33STK241.17178368
34MAP3K121.10733845
35MET1.09266564
36STK101.09181973
37PTK21.04510850
38PRKCI1.03926947
39NME21.01382215
40MAPKAPK30.98264523
41STK380.97467258
42EPHB20.97075715
43SGK4940.93726565
44SGK2230.93726565
45RIPK10.93070345
46PKN20.91901157
47FGFR40.91503245
48WNK10.89961520
49MATK0.88023685
50MAP3K20.87227242
51IRAK30.84818899
52TIE10.80835547
53PBK0.79941285
54TGFBR20.76886172
55EPHB10.70261075
56MAPK150.65823158
57GSK3A0.64309473
58MAP3K10.62718035
59CDC42BPA0.62717081
60RPS6KA20.62323242
61MAP3K110.62227184
62PDGFRA0.61277227
63MAP2K10.59561319
64ICK0.59480377
65NEK60.58851984
66SIK10.58791750
67DYRK1B0.56551894
68MAP2K60.56370349
69MAP3K80.53872366
70DMPK0.52966562
71GRK60.52817757
72SGK30.51821791
73MYLK0.47467325
74PINK10.45345469
75TTK0.44153072
76MUSK0.42798414
77MAP2K30.40303006
78EIF2AK30.40246723
79CHUK0.39654281
80ZAP700.39056142
81PRKG20.38671298
82SCYL20.38128096
83AKT20.34795642
84MTOR0.34346855
85MAP3K70.34324978
86RPS6KL10.33792158
87RPS6KC10.33792158
88PIK3CG0.33429753
89PDPK10.33250484
90PRKD20.33095463
91NEK90.32434527
92SGK20.32144163
93MAPKAPK20.32106271
94NTRK10.31354349
95ERBB20.31295741
96ILK0.30998831
97ABL20.30076923
98DDR20.28891100
99VRK20.28871323
100CSNK1A10.28810353
101CAMK2D0.28240559
102FGFR30.27986092
103TESK10.27596224
104CAMK2G0.27201887
105TAOK30.27191622
106DAPK10.26069625
107CDK70.25847392
108SRC0.25756322
109DAPK20.25722136
110MAP3K60.25324880
111TAOK10.24812017
112PRKCZ0.24471484
113AURKA0.23833264
114GRK10.22773283
115MAPK110.22165581
116EPHA30.22041107
117RPS6KA60.21927176
118AURKB0.21666779
119TNIK0.21599750
120CDK120.21411896
121MKNK20.19788453
122TBK10.19644875
123PDGFRB0.19641843
124EEF2K0.19441785
125CDK60.19224867
126STK30.19159181
127PRKCD0.18783603
128RET0.18692452
129SGK10.17549257
130PRKAA10.17415320
131AKT30.16469143
132KDR0.16287495
133INSRR0.16119929
134BMX0.15733872
135FGFR20.15719100
136ERBB40.15120654
137NUAK10.15079696
138FGFR10.14773919
139PRKAA20.14188330
140RPS6KA40.14150974
141CSNK1E0.13464019

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.64398321
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.12519056
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07946047
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.88608003
5Propanoate metabolism_Homo sapiens_hsa006402.85124102
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73123257
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.66813828
8Butanoate metabolism_Homo sapiens_hsa006502.65419062
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.59405983
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40943421
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39434734
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39112561
13Vitamin digestion and absorption_Homo sapiens_hsa049772.36457252
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22729358
15Fatty acid degradation_Homo sapiens_hsa000712.22450982
16Protein digestion and absorption_Homo sapiens_hsa049742.20945332
17Peroxisome_Homo sapiens_hsa041462.12176282
18Tryptophan metabolism_Homo sapiens_hsa003802.05933378
19Pyruvate metabolism_Homo sapiens_hsa006201.97697173
20Glutathione metabolism_Homo sapiens_hsa004801.96224770
21beta-Alanine metabolism_Homo sapiens_hsa004101.92454507
22Sulfur metabolism_Homo sapiens_hsa009201.91150973
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91059056
24Folate biosynthesis_Homo sapiens_hsa007901.66059313
25Arginine and proline metabolism_Homo sapiens_hsa003301.61035215
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59152597
27Selenocompound metabolism_Homo sapiens_hsa004501.56143440
28Fat digestion and absorption_Homo sapiens_hsa049751.51936449
29Carbon metabolism_Homo sapiens_hsa012001.50454119
30Pancreatic secretion_Homo sapiens_hsa049721.46040296
31Fatty acid metabolism_Homo sapiens_hsa012121.44456572
32Bile secretion_Homo sapiens_hsa049761.43875978
33Collecting duct acid secretion_Homo sapiens_hsa049661.43769429
34Other glycan degradation_Homo sapiens_hsa005111.43225933
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.42031362
36Mineral absorption_Homo sapiens_hsa049781.40364492
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36759053
38Glycerolipid metabolism_Homo sapiens_hsa005611.36508043
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34579592
40Histidine metabolism_Homo sapiens_hsa003401.32030478
41Arginine biosynthesis_Homo sapiens_hsa002201.24816708
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20432166
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18000291
44Biosynthesis of amino acids_Homo sapiens_hsa012301.17903385
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.13909211
46PPAR signaling pathway_Homo sapiens_hsa033201.12265263
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09543477
48Chemical carcinogenesis_Homo sapiens_hsa052041.06655209
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05824260
50Lysine degradation_Homo sapiens_hsa003101.04654821
51Starch and sucrose metabolism_Homo sapiens_hsa005001.04384879
52Fructose and mannose metabolism_Homo sapiens_hsa000511.02048213
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.01173721
54Renin-angiotensin system_Homo sapiens_hsa046140.98500734
55Nitrogen metabolism_Homo sapiens_hsa009100.95381128
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94819198
57Phenylalanine metabolism_Homo sapiens_hsa003600.94387874
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94179534
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93662185
60Ether lipid metabolism_Homo sapiens_hsa005650.89476395
61Thyroid cancer_Homo sapiens_hsa052160.84173554
62Pentose phosphate pathway_Homo sapiens_hsa000300.77871508
63Arachidonic acid metabolism_Homo sapiens_hsa005900.76249242
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74839668
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.73956222
66Thyroid hormone synthesis_Homo sapiens_hsa049180.70438407
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.70058168
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69926229
69Lysosome_Homo sapiens_hsa041420.67940453
70Fatty acid biosynthesis_Homo sapiens_hsa000610.64228199
71Sulfur relay system_Homo sapiens_hsa041220.62749984
72Metabolic pathways_Homo sapiens_hsa011000.62656206
73Retinol metabolism_Homo sapiens_hsa008300.60945697
74Oxidative phosphorylation_Homo sapiens_hsa001900.57634487
75Vibrio cholerae infection_Homo sapiens_hsa051100.57134956
76Tight junction_Homo sapiens_hsa045300.56231153
77N-Glycan biosynthesis_Homo sapiens_hsa005100.54188745
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53097796
79Fatty acid elongation_Homo sapiens_hsa000620.52193193
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51720671
81Galactose metabolism_Homo sapiens_hsa000520.50379549
82Tyrosine metabolism_Homo sapiens_hsa003500.47636632
83One carbon pool by folate_Homo sapiens_hsa006700.47434127
84Bladder cancer_Homo sapiens_hsa052190.47318209
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.47077256
86Steroid biosynthesis_Homo sapiens_hsa001000.45519835
87Notch signaling pathway_Homo sapiens_hsa043300.45451080
88Caffeine metabolism_Homo sapiens_hsa002320.43459918
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42232671
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.42055290
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37851904
92Ribosome_Homo sapiens_hsa030100.37525315
93Linoleic acid metabolism_Homo sapiens_hsa005910.34932960
94Protein export_Homo sapiens_hsa030600.34649574
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.33944411
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30343809
97AMPK signaling pathway_Homo sapiens_hsa041520.30047079
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26198633
99Sphingolipid metabolism_Homo sapiens_hsa006000.26086683
100Hippo signaling pathway_Homo sapiens_hsa043900.26037246
101Gastric acid secretion_Homo sapiens_hsa049710.24613222
102Glucagon signaling pathway_Homo sapiens_hsa049220.22809128
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22197138
104Parkinsons disease_Homo sapiens_hsa050120.21999953
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.21834375
106Insulin signaling pathway_Homo sapiens_hsa049100.21108961
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20435027
108ABC transporters_Homo sapiens_hsa020100.19413868
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18967431
110ECM-receptor interaction_Homo sapiens_hsa045120.18540143
111Hepatitis C_Homo sapiens_hsa051600.16102181
112Amoebiasis_Homo sapiens_hsa051460.16054176
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15364111
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13689108
115Endometrial cancer_Homo sapiens_hsa052130.11681018
116Insulin resistance_Homo sapiens_hsa049310.10130378
117Adherens junction_Homo sapiens_hsa045200.09679880
118Vitamin B6 metabolism_Homo sapiens_hsa007500.09218022
119Basal cell carcinoma_Homo sapiens_hsa052170.06168782

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