PRTFDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CENP-A containing nucleosome assembly (GO:0034080)4.38511564
2chromatin remodeling at centromere (GO:0031055)4.34281272
3protein neddylation (GO:0045116)4.33151730
4presynaptic membrane assembly (GO:0097105)3.99906778
5histone exchange (GO:0043486)3.73778333
6presynaptic membrane organization (GO:0097090)3.65544455
7L-serine metabolic process (GO:0006563)3.55691097
8postsynaptic membrane organization (GO:0001941)3.51695378
9DNA double-strand break processing (GO:0000729)3.49073025
10microtubule depolymerization (GO:0007019)3.37230948
11DNA replication-independent nucleosome organization (GO:0034724)3.35277714
12DNA replication-independent nucleosome assembly (GO:0006336)3.35277714
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16136637
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16136637
15cullin deneddylation (GO:0010388)3.13059785
16DNA ligation (GO:0006266)3.11753897
17kinetochore organization (GO:0051383)3.04327866
18protein localization to kinetochore (GO:0034501)2.94776702
19adenosine metabolic process (GO:0046085)2.89051334
20negative regulation of DNA-dependent DNA replication (GO:2000104)2.86703934
21folic acid-containing compound biosynthetic process (GO:0009396)2.85217589
22proteasome assembly (GO:0043248)2.84223132
23kinetochore assembly (GO:0051382)2.83991544
24protein K6-linked ubiquitination (GO:0085020)2.80656781
25platelet dense granule organization (GO:0060155)2.80505859
26metaphase plate congression (GO:0051310)2.74048188
27establishment of integrated proviral latency (GO:0075713)2.73215774
28neuron cell-cell adhesion (GO:0007158)2.73167747
29otic vesicle formation (GO:0030916)2.71695403
30cysteine metabolic process (GO:0006534)2.68193440
31sequestering of actin monomers (GO:0042989)2.65919886
32protein deneddylation (GO:0000338)2.65269155
33pyrimidine nucleobase catabolic process (GO:0006208)2.62059402
34replication fork processing (GO:0031297)2.58989916
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58289074
36DNA replication-dependent nucleosome assembly (GO:0006335)2.56572124
37DNA replication-dependent nucleosome organization (GO:0034723)2.56572124
38mitotic metaphase plate congression (GO:0007080)2.52915848
39limb bud formation (GO:0060174)2.52275652
40pteridine-containing compound biosynthetic process (GO:0042559)2.51319878
41protein-cofactor linkage (GO:0018065)2.49099434
42centriole replication (GO:0007099)2.48539304
43microtubule polymerization or depolymerization (GO:0031109)2.47558869
44DNA strand elongation involved in DNA replication (GO:0006271)2.44810725
45sulfur amino acid catabolic process (GO:0000098)2.43789781
46regulation of centriole replication (GO:0046599)2.42652216
47serine family amino acid biosynthetic process (GO:0009070)2.42646954
48positive regulation of oligodendrocyte differentiation (GO:0048714)2.40869266
49positive regulation of endothelial cell differentiation (GO:0045603)2.39892136
50maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.36199927
51homocysteine metabolic process (GO:0050667)2.35145389
52negative regulation of DNA recombination (GO:0045910)2.34851391
53negative regulation of heart rate (GO:0010459)2.33375392
54DNA strand elongation (GO:0022616)2.32659248
55intraciliary transport (GO:0042073)2.31829983
56chaperone-mediated protein transport (GO:0072321)2.30114386
57protein heterotetramerization (GO:0051290)2.29955168
58negative regulation of protein localization to cell surface (GO:2000009)2.28903466
59nonmotile primary cilium assembly (GO:0035058)2.27074531
60axon ensheathment in central nervous system (GO:0032291)2.26904238
61central nervous system myelination (GO:0022010)2.26904238
62telomere maintenance via semi-conservative replication (GO:0032201)2.25338524
63protein localization to chromosome, centromeric region (GO:0071459)2.25084214
64resolution of meiotic recombination intermediates (GO:0000712)2.24971728
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.24077514
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.24077514
67NADH dehydrogenase complex assembly (GO:0010257)2.24077514
68non-recombinational repair (GO:0000726)2.23859187
69double-strand break repair via nonhomologous end joining (GO:0006303)2.23859187
70mismatch repair (GO:0006298)2.22965139
71establishment of chromosome localization (GO:0051303)2.22038779
72spermatid nucleus differentiation (GO:0007289)2.22007436
73protein complex biogenesis (GO:0070271)2.20164898
74nucleobase catabolic process (GO:0046113)2.18121132
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.18086727
76retinal ganglion cell axon guidance (GO:0031290)2.17204115
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.17141184
78sulfur amino acid biosynthetic process (GO:0000097)2.17001236
79ATP-dependent chromatin remodeling (GO:0043044)2.16798669
80DNA replication checkpoint (GO:0000076)2.16282761
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.15943473
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.14900601
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.14237625
84mitochondrial respiratory chain complex assembly (GO:0033108)2.13369244
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.12993533
86regulation of development, heterochronic (GO:0040034)2.12944607
87regulation of timing of cell differentiation (GO:0048505)2.12419568
88postreplication repair (GO:0006301)2.11781373
89C4-dicarboxylate transport (GO:0015740)2.11126385
90regulation of cilium movement (GO:0003352)2.10305829
91spindle checkpoint (GO:0031577)2.08839512
92DNA topological change (GO:0006265)2.08807073
93mitotic spindle organization (GO:0007052)2.08663387
94mitotic sister chromatid segregation (GO:0000070)2.08613151
95DNA catabolic process, exonucleolytic (GO:0000738)2.08573792
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.08414647
97histone H2A acetylation (GO:0043968)2.08404111
98neuron fate determination (GO:0048664)2.08217476
99axonal fasciculation (GO:0007413)2.07910678
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.05413898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.33688113
2GBX2_23144817_ChIP-Seq_PC3_Human3.33239339
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25354980
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96502843
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76169596
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54877531
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49327955
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.38982774
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36689437
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36629257
11EWS_26573619_Chip-Seq_HEK293_Human2.34899459
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16164292
13EZH2_22144423_ChIP-Seq_EOC_Human2.15999859
14FUS_26573619_Chip-Seq_HEK293_Human2.10289436
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.09775267
16VDR_22108803_ChIP-Seq_LS180_Human2.09400095
17P300_19829295_ChIP-Seq_ESCs_Human2.04420812
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.02520359
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98645256
20* ELK1_19687146_ChIP-ChIP_HELA_Human1.91658777
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91561628
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.90232588
23TAF15_26573619_Chip-Seq_HEK293_Human1.88520314
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83055590
25IGF1R_20145208_ChIP-Seq_DFB_Human1.82173586
26ZNF274_21170338_ChIP-Seq_K562_Hela1.81043008
27SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78831428
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.76906959
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75547187
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74406496
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.70303652
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68569948
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68281499
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.65759696
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58261308
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57838208
37AR_21909140_ChIP-Seq_LNCAP_Human1.57204558
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53077477
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50146310
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50046370
41SMAD4_21799915_ChIP-Seq_A2780_Human1.49913210
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48467446
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.46840726
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37213372
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.30033147
46AR_25329375_ChIP-Seq_VCAP_Human1.28930650
47* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28303448
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27706938
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26867986
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26531058
51BCAT_22108803_ChIP-Seq_LS180_Human1.24250382
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24250094
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23359901
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20807382
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20742880
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.20073095
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19822695
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19611918
59SOX9_26525672_Chip-Seq_HEART_Mouse1.19464052
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19100311
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.18327214
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15383761
63HTT_18923047_ChIP-ChIP_STHdh_Human1.12032044
64STAT3_23295773_ChIP-Seq_U87_Human1.11298512
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.11140796
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10747211
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10252178
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.09725905
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09418808
70JUN_21703547_ChIP-Seq_K562_Human1.07970675
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07684562
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07162118
73RNF2_27304074_Chip-Seq_NSC_Mouse1.06329797
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05817722
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05807380
76SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05033457
77MYC_18940864_ChIP-ChIP_HL60_Human1.04955459
78SOX2_19829295_ChIP-Seq_ESCs_Human1.03795922
79NANOG_19829295_ChIP-Seq_ESCs_Human1.03795922
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03708215
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03336450
82TCF4_22108803_ChIP-Seq_LS180_Human1.02660016
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02289684
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.02012434
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01554117
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98005004
87TAL1_26923725_Chip-Seq_HPCs_Mouse0.97696806
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97067169
89P53_22387025_ChIP-Seq_ESCs_Mouse0.97038222
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97026901
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96693978
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95199496
93ER_23166858_ChIP-Seq_MCF-7_Human0.94549006
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94339139
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94028053
96* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93786168
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92602477
98CBP_20019798_ChIP-Seq_JUKART_Human0.92602477
99TCF4_23295773_ChIP-Seq_U87_Human0.90683860
100WT1_19549856_ChIP-ChIP_CCG9911_Human0.90374009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after3.05152043
2MP0003880_abnormal_central_pattern2.73299226
3MP0002102_abnormal_ear_morphology2.51321360
4MP0003136_yellow_coat_color2.40381866
5MP0006072_abnormal_retinal_apoptosis2.26487134
6MP0010094_abnormal_chromosome_stability2.10533224
7MP0001968_abnormal_touch/_nociception2.06644876
8MP0001529_abnormal_vocalization2.06437571
9MP0002938_white_spotting2.06299391
10MP0008058_abnormal_DNA_repair2.01459618
11MP0002653_abnormal_ependyma_morphology1.84919050
12MP0005646_abnormal_pituitary_gland1.82439851
13MP0002735_abnormal_chemical_nociception1.76031288
14MP0005253_abnormal_eye_physiology1.72640178
15MP0000778_abnormal_nervous_system1.68502263
16MP0005171_absent_coat_pigmentation1.66591039
17MP0008932_abnormal_embryonic_tissue1.64036131
18MP0003890_abnormal_embryonic-extraembry1.61336441
19MP0004147_increased_porphyrin_level1.60661214
20MP0005551_abnormal_eye_electrophysiolog1.58006086
21MP0008789_abnormal_olfactory_epithelium1.55728726
22MP0001293_anophthalmia1.54019794
23MP0003937_abnormal_limbs/digits/tail_de1.52020560
24MP0006292_abnormal_olfactory_placode1.46394778
25MP0000647_abnormal_sebaceous_gland1.43615071
26MP0004885_abnormal_endolymph1.43439651
27MP0002233_abnormal_nose_morphology1.43250422
28MP0003718_maternal_effect1.42321759
29MP0008995_early_reproductive_senescence1.40982107
30MP0004133_heterotaxia1.38076823
31MP0001286_abnormal_eye_development1.38022897
32MP0006276_abnormal_autonomic_nervous1.36591224
33MP0009697_abnormal_copulation1.34901581
34MP0000534_abnormal_ureter_morphology1.33599267
35MP0005248_abnormal_Harderian_gland1.32731277
36MP0002234_abnormal_pharynx_morphology1.32212373
37MP0003283_abnormal_digestive_organ1.31248354
38MP0005084_abnormal_gallbladder_morpholo1.31092582
39MP0003119_abnormal_digestive_system1.29285795
40MP0003111_abnormal_nucleus_morphology1.29141385
41MP0003755_abnormal_palate_morphology1.29112091
42MP0000516_abnormal_urinary_system1.27972311
43MP0005367_renal/urinary_system_phenotyp1.27972311
44MP0000631_abnormal_neuroendocrine_gland1.27160592
45MP0000049_abnormal_middle_ear1.27103791
46MP0001486_abnormal_startle_reflex1.25747222
47MP0002638_abnormal_pupillary_reflex1.24717224
48MP0009250_abnormal_appendicular_skeleto1.23708977
49MP0001984_abnormal_olfaction1.22984873
50MP0002751_abnormal_autonomic_nervous1.22613341
51MP0005394_taste/olfaction_phenotype1.18408533
52MP0005499_abnormal_olfactory_system1.18408533
53MP0002697_abnormal_eye_size1.17822341
54MP0000566_synostosis1.16607856
55MP0005187_abnormal_penis_morphology1.12043086
56MP0003942_abnormal_urinary_system1.10603246
57MP0000026_abnormal_inner_ear1.10426050
58MP0010030_abnormal_orbit_morphology1.09719300
59MP0004957_abnormal_blastocyst_morpholog1.06503729
60MP0005391_vision/eye_phenotype1.05715352
61MP0009745_abnormal_behavioral_response1.04685313
62MP0002822_catalepsy1.03601111
63MP0001485_abnormal_pinna_reflex1.02968455
64MP0004142_abnormal_muscle_tone1.02346623
65MP0002272_abnormal_nervous_system1.02289231
66MP0002282_abnormal_trachea_morphology1.02125323
67MP0002734_abnormal_mechanical_nocicepti1.01391448
68MP0003121_genomic_imprinting0.99231557
69MP0002184_abnormal_innervation0.99112672
70MP0009046_muscle_twitch0.98899282
71MP0002733_abnormal_thermal_nociception0.98432018
72MP0009053_abnormal_anal_canal0.96730756
73MP0005503_abnormal_tendon_morphology0.96248072
74MP0001970_abnormal_pain_threshold0.96201383
75MP0001299_abnormal_eye_distance/0.94408827
76MP0003635_abnormal_synaptic_transmissio0.93933846
77MP0003077_abnormal_cell_cycle0.93463239
78MP0002295_abnormal_pulmonary_circulatio0.93258797
79MP0005195_abnormal_posterior_eye0.92475714
80MP0003861_abnormal_nervous_system0.88680453
81MP0004859_abnormal_synaptic_plasticity0.88175745
82MP0003693_abnormal_embryo_hatching0.87096625
83MP0004215_abnormal_myocardial_fiber0.86312306
84MP0003935_abnormal_craniofacial_develop0.86289489
85MP0002557_abnormal_social/conspecific_i0.85579148
86MP0001963_abnormal_hearing_physiology0.85420024
87MP0002572_abnormal_emotion/affect_behav0.85395713
88MP0002752_abnormal_somatic_nervous0.84202855
89MP0003786_premature_aging0.84005497
90MP0000013_abnormal_adipose_tissue0.83700122
91MP0002064_seizures0.81895179
92MP0003186_abnormal_redox_activity0.81656729
93MP0002111_abnormal_tail_morphology0.80589396
94MP0002837_dystrophic_cardiac_calcinosis0.80020246
95MP0002882_abnormal_neuron_morphology0.79071818
96MP0001177_atelectasis0.78676443
97MP0000955_abnormal_spinal_cord0.78431252
98MP0008007_abnormal_cellular_replicative0.78079293
99MP0008872_abnormal_physiological_respon0.77640542
100MP0002067_abnormal_sensory_capabilities0.77326570

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.84571377
2True hermaphroditism (HP:0010459)3.35696030
3Intestinal atresia (HP:0011100)3.15598878
4Pancreatic fibrosis (HP:0100732)2.84985141
5Aplasia/Hypoplasia of the uvula (HP:0010293)2.81645100
6Pancreatic cysts (HP:0001737)2.69601459
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69227344
8Abnormality of alanine metabolism (HP:0010916)2.69227344
9Hyperalaninemia (HP:0003348)2.69227344
10Colon cancer (HP:0003003)2.57377545
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52265543
12Abnormality of midbrain morphology (HP:0002418)2.50694544
13Molar tooth sign on MRI (HP:0002419)2.50694544
14Acute necrotizing encephalopathy (HP:0006965)2.48584615
15Hyperglycinemia (HP:0002154)2.45191737
16Gastrointestinal atresia (HP:0002589)2.41396059
17Progressive macrocephaly (HP:0004481)2.36216153
18Optic nerve hypoplasia (HP:0000609)2.35644880
19Acute encephalopathy (HP:0006846)2.34397321
20Medial flaring of the eyebrow (HP:0010747)2.32601241
21Supernumerary spleens (HP:0009799)2.31411633
22Meckel diverticulum (HP:0002245)2.28760586
23Abnormality of the ileum (HP:0001549)2.25773856
24Cortical dysplasia (HP:0002539)2.24410980
25Nephronophthisis (HP:0000090)2.21756746
26Abnormality of serum amino acid levels (HP:0003112)2.17192384
27Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16808141
28Abnormal lung lobation (HP:0002101)2.16104071
29Hemiparesis (HP:0001269)2.14309028
30Short tibia (HP:0005736)2.13669965
31Gait imbalance (HP:0002141)2.13509303
32Chromsome breakage (HP:0040012)2.12984615
33Septo-optic dysplasia (HP:0100842)2.12357152
34Congenital primary aphakia (HP:0007707)2.12156430
35Nephrogenic diabetes insipidus (HP:0009806)2.11364031
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.08343332
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.07283607
38Volvulus (HP:0002580)2.06723897
39Focal motor seizures (HP:0011153)2.05708175
40Abnormal mitochondria in muscle tissue (HP:0008316)2.05132616
41Abnormality of chromosome stability (HP:0003220)2.03775766
42Preaxial hand polydactyly (HP:0001177)2.01878826
43Postaxial foot polydactyly (HP:0001830)2.01020401
44Split foot (HP:0001839)1.99188660
45Increased corneal curvature (HP:0100692)1.98993873
46Keratoconus (HP:0000563)1.98993873
47Postnatal microcephaly (HP:0005484)1.96118885
48Genital tract atresia (HP:0001827)1.95891469
49Abnormal umbilical cord blood vessels (HP:0011403)1.93457922
50Single umbilical artery (HP:0001195)1.93457922
51Abnormality of the fetal cardiovascular system (HP:0010948)1.93457922
52Action tremor (HP:0002345)1.93347943
53Anencephaly (HP:0002323)1.92695224
54Sclerocornea (HP:0000647)1.91202040
55Postaxial hand polydactyly (HP:0001162)1.90797157
56Broad foot (HP:0001769)1.90009007
57Increased mean platelet volume (HP:0011877)1.88554163
58Vaginal atresia (HP:0000148)1.88436700
59Renal hypoplasia (HP:0000089)1.88395423
60Birth length less than 3rd percentile (HP:0003561)1.87818943
61Abnormality of the duodenum (HP:0002246)1.86077187
62Mitochondrial inheritance (HP:0001427)1.85128435
63Pendular nystagmus (HP:0012043)1.84966699
64Occipital encephalocele (HP:0002085)1.84434181
65Petechiae (HP:0000967)1.83685433
66Triphalangeal thumb (HP:0001199)1.83070859
67Conjunctival telangiectasia (HP:0000524)1.82804085
68Small intestinal stenosis (HP:0012848)1.80663154
69Duodenal stenosis (HP:0100867)1.80663154
70Methylmalonic acidemia (HP:0002912)1.80343729
71Maternal diabetes (HP:0009800)1.80061005
72Abnormality of glycine metabolism (HP:0010895)1.79378115
73Abnormality of serine family amino acid metabolism (HP:0010894)1.79378115
74Hemivertebrae (HP:0002937)1.78844969
75Hypoplastic pelvis (HP:0008839)1.75724644
76Oligodactyly (hands) (HP:0001180)1.75014594
77Anophthalmia (HP:0000528)1.74384785
78Chorioretinal atrophy (HP:0000533)1.73583836
79Delayed gross motor development (HP:0002194)1.72434296
80Abnormality of the preputium (HP:0100587)1.71085232
81Median cleft lip (HP:0000161)1.70588199
82Sloping forehead (HP:0000340)1.68945570
83Patchy hypopigmentation of hair (HP:0011365)1.68915969
84Esophageal atresia (HP:0002032)1.68859781
85Cerebral edema (HP:0002181)1.68802609
86Atonic seizures (HP:0010819)1.68250507
87Male pseudohermaphroditism (HP:0000037)1.67939309
88Long clavicles (HP:0000890)1.65927898
89Lissencephaly (HP:0001339)1.64838002
90Increased CSF lactate (HP:0002490)1.63385808
91Abnormality of the renal medulla (HP:0100957)1.61342942
92Constricted visual fields (HP:0001133)1.61170510
93Retinal dysplasia (HP:0007973)1.60886539
94Aganglionic megacolon (HP:0002251)1.59725042
95Hepatic necrosis (HP:0002605)1.59646511
96Abnormality of the carotid arteries (HP:0005344)1.59129960
97Fibular hypoplasia (HP:0003038)1.58705964
98Abolished electroretinogram (ERG) (HP:0000550)1.57398549
99Menorrhagia (HP:0000132)1.57015933
100Hepatocellular necrosis (HP:0001404)1.56370283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK22.57626375
2WEE12.44260137
3CASK2.36378987
4MST42.32732305
5TNIK2.29458470
6WNK32.26160986
7PNCK2.22275342
8TRIM282.15958479
9MKNK22.06918766
10PLK32.05717884
11CDC72.05540547
12VRK11.97190561
13EPHB21.88123785
14BUB11.83999329
15BRSK21.82857030
16PLK21.81524610
17PLK41.77157923
18BMPR1B1.77009743
19ZAK1.74617811
20PBK1.73732656
21MKNK11.73488279
22TTK1.64558820
23EIF2AK11.63352485
24NEK11.59170527
25BCR1.58568941
26NTRK21.57382494
27FRK1.55665629
28MAP3K41.43387085
29NUAK11.42826929
30MARK11.42129600
31ERBB31.39153445
32CCNB11.37220978
33MAP4K21.33871499
34DYRK21.32597710
35SRPK11.31024786
36CSNK1G11.30742068
37EPHA41.30073496
38ACVR1B1.25534078
39MAPK131.25204385
40STK38L1.21685972
41PLK11.16530326
42CSNK1G31.12876270
43CSNK1G21.11986133
44TSSK61.08885771
45MAP2K71.08271147
46MYLK1.02022540
47UHMK10.96835856
48TAF10.91940644
49PKN10.89135565
50STK30.88512351
51NTRK30.85639399
52BCKDK0.83943796
53BRSK10.83526182
54RPS6KA40.82980156
55MINK10.81770462
56EIF2AK30.81722342
57PRKCG0.81060451
58CSNK1A1L0.79251234
59PTK2B0.76734961
60PRKCE0.75799145
61SGK20.73281932
62LIMK10.73063576
63ERBB40.72915871
64FGFR20.72657355
65ATR0.72175903
66ADRBK10.71699878
67DYRK30.71250411
68ADRBK20.70845246
69GRK50.68705180
70AURKB0.68583713
71CAMK2G0.64299359
72EIF2AK20.64179178
73PINK10.64173665
74CAMK2B0.62354509
75PRKD30.62115784
76CAMK2D0.61695669
77CHEK20.61027059
78MAP3K120.60349243
79BMX0.58825215
80SGK2230.57580384
81SGK4940.57580384
82NME10.56483057
83MAPK150.51868688
84GRK10.50988715
85CAMK2A0.50201872
86ROCK10.47738294
87ATM0.45714423
88ROCK20.45488196
89NEK20.44855085
90NTRK10.44263382
91PAK30.44146116
92AURKA0.43900162
93CDK30.43607662
94CDK140.43596520
95PAK60.43353328
96ERBB20.43295549
97CSNK1A10.40988235
98ILK0.40393739
99CDK80.39855194
100PASK0.39200214

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.18201999
2Proteasome_Homo sapiens_hsa030502.54928328
3Protein export_Homo sapiens_hsa030602.53370115
4DNA replication_Homo sapiens_hsa030302.45056012
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38835264
6Fanconi anemia pathway_Homo sapiens_hsa034602.33213285
7Homologous recombination_Homo sapiens_hsa034402.19178036
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09489920
9One carbon pool by folate_Homo sapiens_hsa006702.00628833
10Steroid biosynthesis_Homo sapiens_hsa001001.97832571
11Oxidative phosphorylation_Homo sapiens_hsa001901.89073405
12Propanoate metabolism_Homo sapiens_hsa006401.85659940
13Base excision repair_Homo sapiens_hsa034101.82410250
14Parkinsons disease_Homo sapiens_hsa050121.69189592
15RNA polymerase_Homo sapiens_hsa030201.69042489
16Nucleotide excision repair_Homo sapiens_hsa034201.60325731
17Sulfur metabolism_Homo sapiens_hsa009201.59821515
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59396692
19Non-homologous end-joining_Homo sapiens_hsa034501.57666027
20Butanoate metabolism_Homo sapiens_hsa006501.54152865
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47089677
22Basal transcription factors_Homo sapiens_hsa030221.44818437
23Fatty acid elongation_Homo sapiens_hsa000621.44671870
24Nicotine addiction_Homo sapiens_hsa050331.39454574
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38292096
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29603338
27GABAergic synapse_Homo sapiens_hsa047271.29387458
28Huntingtons disease_Homo sapiens_hsa050161.28793554
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.27833685
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26672887
31Cell cycle_Homo sapiens_hsa041101.25537150
32Nitrogen metabolism_Homo sapiens_hsa009101.24568040
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.23725515
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22216226
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20294424
36Folate biosynthesis_Homo sapiens_hsa007901.14972208
37Glutathione metabolism_Homo sapiens_hsa004801.13624981
38Spliceosome_Homo sapiens_hsa030401.10951420
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08239720
40Purine metabolism_Homo sapiens_hsa002301.07552268
41Phototransduction_Homo sapiens_hsa047441.06915528
42Pyrimidine metabolism_Homo sapiens_hsa002401.03437634
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03350588
44Collecting duct acid secretion_Homo sapiens_hsa049661.02428905
45RNA transport_Homo sapiens_hsa030131.00910573
46Alzheimers disease_Homo sapiens_hsa050101.00322112
47beta-Alanine metabolism_Homo sapiens_hsa004100.97704746
48Selenocompound metabolism_Homo sapiens_hsa004500.97473353
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95731328
50Circadian entrainment_Homo sapiens_hsa047130.93796403
51Pyruvate metabolism_Homo sapiens_hsa006200.91167365
52Oocyte meiosis_Homo sapiens_hsa041140.89341057
53Vitamin B6 metabolism_Homo sapiens_hsa007500.87239192
54Alcoholism_Homo sapiens_hsa050340.86996785
55Morphine addiction_Homo sapiens_hsa050320.85763479
56Biosynthesis of amino acids_Homo sapiens_hsa012300.85242542
57Hedgehog signaling pathway_Homo sapiens_hsa043400.81628143
58RNA degradation_Homo sapiens_hsa030180.79102726
59Arginine and proline metabolism_Homo sapiens_hsa003300.78855331
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77548782
61Hippo signaling pathway_Homo sapiens_hsa043900.77365931
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77266532
63Basal cell carcinoma_Homo sapiens_hsa052170.77122429
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77021222
65Glutamatergic synapse_Homo sapiens_hsa047240.76205237
66Dopaminergic synapse_Homo sapiens_hsa047280.75712492
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72278829
68Peroxisome_Homo sapiens_hsa041460.71071658
69Serotonergic synapse_Homo sapiens_hsa047260.71041243
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65947005
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64550419
72Gap junction_Homo sapiens_hsa045400.63082232
73Fatty acid metabolism_Homo sapiens_hsa012120.62017294
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61485816
75Taste transduction_Homo sapiens_hsa047420.60930822
76Metabolic pathways_Homo sapiens_hsa011000.60285721
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54505106
78Wnt signaling pathway_Homo sapiens_hsa043100.52340917
79Synaptic vesicle cycle_Homo sapiens_hsa047210.51991152
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49993894
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49628629
82Tryptophan metabolism_Homo sapiens_hsa003800.49414792
83ECM-receptor interaction_Homo sapiens_hsa045120.48486634
84Olfactory transduction_Homo sapiens_hsa047400.48153646
85TGF-beta signaling pathway_Homo sapiens_hsa043500.47386508
86Carbon metabolism_Homo sapiens_hsa012000.47301562
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46980921
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46812273
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46514971
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45439258
91Cardiac muscle contraction_Homo sapiens_hsa042600.45231552
92Amphetamine addiction_Homo sapiens_hsa050310.44274212
93Glycerolipid metabolism_Homo sapiens_hsa005610.43958951
94Regulation of autophagy_Homo sapiens_hsa041400.41079194
95Cocaine addiction_Homo sapiens_hsa050300.41039249
96Fatty acid degradation_Homo sapiens_hsa000710.39858886
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39772785
98p53 signaling pathway_Homo sapiens_hsa041150.39477449
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38647861
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38222533

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