PRTG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the immunoglobulin superfamily. The encoded transmembrane protein has been associated with the development of various tissues, especially neurogenesis. It has been suggested that this gene may be associated with attention deficit hyperactivity disorder (ADHD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)6.31693685
2pre-miRNA processing (GO:0031054)6.30725086
3regulation of posttranscriptional gene silencing (GO:0060147)6.07015345
4regulation of gene silencing by miRNA (GO:0060964)6.07015345
5regulation of gene silencing by RNA (GO:0060966)6.07015345
6lateral sprouting from an epithelium (GO:0060601)4.88171985
7DNA unwinding involved in DNA replication (GO:0006268)4.78221164
8kinetochore organization (GO:0051383)4.59069092
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.51743809
10regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.50056221
11negative regulation of cell fate specification (GO:0009996)4.46042125
12nuclear pore organization (GO:0006999)4.43229625
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.36319825
14nuclear pore complex assembly (GO:0051292)4.28694032
15convergent extension (GO:0060026)4.25041225
16mitotic metaphase plate congression (GO:0007080)4.24753671
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.20644759
18kinetochore assembly (GO:0051382)4.18732240
19limb bud formation (GO:0060174)4.18572666
20regulation of non-canonical Wnt signaling pathway (GO:2000050)4.17904760
21peptidyl-arginine omega-N-methylation (GO:0035247)4.11036932
22positive regulation of gastrulation (GO:2000543)4.04898799
23metaphase plate congression (GO:0051310)3.87929908
24establishment of integrated proviral latency (GO:0075713)3.77779519
25cell proliferation in forebrain (GO:0021846)3.72321707
26positive regulation of catenin import into nucleus (GO:0035413)3.67780618
27dorsal/ventral axis specification (GO:0009950)3.65407289
28protein localization to kinetochore (GO:0034501)3.63115107
29pituitary gland development (GO:0021983)3.61822555
30regulation of mesoderm development (GO:2000380)3.58066528
31post-anal tail morphogenesis (GO:0036342)3.57756059
32cell surface receptor signaling pathway involved in heart development (GO:0061311)3.57545783
33peptidyl-arginine N-methylation (GO:0035246)3.56634041
34peptidyl-arginine methylation (GO:0018216)3.56634041
35embryonic foregut morphogenesis (GO:0048617)3.54990169
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.48083848
37chromatin remodeling at centromere (GO:0031055)3.47465601
38CENP-A containing nucleosome assembly (GO:0034080)3.46296398
39protein localization to chromosome, centromeric region (GO:0071459)3.45720342
40outer ear morphogenesis (GO:0042473)3.45706663
41histone arginine methylation (GO:0034969)3.45562083
42DNA strand elongation involved in DNA replication (GO:0006271)3.44853918
43DNA replication initiation (GO:0006270)3.42104462
44regulation of cardioblast differentiation (GO:0051890)3.40054021
45Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.39144186
46midbrain development (GO:0030901)3.38774990
47IMP biosynthetic process (GO:0006188)3.38633708
48ncRNA catabolic process (GO:0034661)3.36415021
49mitotic sister chromatid segregation (GO:0000070)3.34142779
50regulation of cell fate specification (GO:0042659)3.33531225
51regulation of telomere maintenance via telomerase (GO:0032210)3.32111587
52branching involved in salivary gland morphogenesis (GO:0060445)3.32047345
53pore complex assembly (GO:0046931)3.31797132
54negative regulation of axon extension involved in axon guidance (GO:0048843)3.30576026
55axon extension involved in axon guidance (GO:0048846)3.27116942
56neuron projection extension involved in neuron projection guidance (GO:1902284)3.27116942
57DNA strand elongation (GO:0022616)3.26314162
58positive regulation of cellular response to oxidative stress (GO:1900409)3.25936014
59positive regulation of response to oxidative stress (GO:1902884)3.25936014
60regulation of establishment of planar polarity (GO:0090175)3.25109965
61neuronal stem cell maintenance (GO:0097150)3.22962577
62meiotic chromosome segregation (GO:0045132)3.22836463
63DNA strand renaturation (GO:0000733)3.22643887
64establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.22330182
65regulation of centriole replication (GO:0046599)3.22248988
66DNA replication-dependent nucleosome assembly (GO:0006335)3.20561261
67DNA replication-dependent nucleosome organization (GO:0034723)3.20561261
68positive regulation of cardiac muscle cell differentiation (GO:2000727)3.18655644
69somite development (GO:0061053)3.17162009
70mesenchymal cell differentiation (GO:0048762)3.16400927
71regulation of stem cell maintenance (GO:2000036)3.12817605
72DNA replication checkpoint (GO:0000076)3.12816219
73non-canonical Wnt signaling pathway (GO:0035567)3.12788120
74histone exchange (GO:0043486)3.11331782
75negative regulation of cell fate commitment (GO:0010454)3.10044448
76negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.09835499
77sister chromatid segregation (GO:0000819)3.06899953
78ribosomal small subunit assembly (GO:0000028)3.05949959
79regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.05774384
80establishment of chromosome localization (GO:0051303)3.05280006
81maturation of SSU-rRNA (GO:0030490)3.03942221
82lung-associated mesenchyme development (GO:0060484)3.03238837
83ATP-dependent chromatin remodeling (GO:0043044)3.02726181
84negative regulation of axon guidance (GO:1902668)3.02333600
85thalamus development (GO:0021794)3.02270462
86telomere maintenance via semi-conservative replication (GO:0032201)3.01724648
87negative regulation of DNA repair (GO:0045738)3.00740401
88facial nerve structural organization (GO:0021612)3.00226865
89positive regulation of embryonic development (GO:0040019)3.00169385
90DNA replication-independent nucleosome assembly (GO:0006336)3.00157363
91DNA replication-independent nucleosome organization (GO:0034724)3.00157363
92cell migration involved in gastrulation (GO:0042074)2.99672598
93heterochromatin organization (GO:0070828)2.99644970
94neuron fate determination (GO:0048664)2.99517884
95genitalia morphogenesis (GO:0035112)2.99388400
96regulation of gene silencing (GO:0060968)2.98960929
97protein-DNA complex disassembly (GO:0032986)2.98636878
98nucleosome disassembly (GO:0006337)2.98636878
99spindle checkpoint (GO:0031577)2.96973952
100notochord development (GO:0030903)2.95332747
101DNA ligation (GO:0006266)2.92610073
102radial glial cell differentiation (GO:0060019)2.92599161
103hematopoietic stem cell proliferation (GO:0071425)2.92078495
104mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.92057044
105somatic stem cell division (GO:0048103)2.91261104
106axis elongation (GO:0003401)2.90787079
107DNA geometric change (GO:0032392)2.90741764
108mitotic recombination (GO:0006312)2.90124938
109nodal signaling pathway (GO:0038092)2.89389880
110artery development (GO:0060840)2.89353827
111intra-S DNA damage checkpoint (GO:0031573)2.88867358
112mitotic nuclear envelope disassembly (GO:0007077)2.88292886
113DNA duplex unwinding (GO:0032508)2.87974163
114mesenchymal cell proliferation (GO:0010463)2.87735606
115viral transcription (GO:0019083)2.87422074
116regulation of centrosome cycle (GO:0046605)2.86483125
117limb development (GO:0060173)2.86308445
118appendage development (GO:0048736)2.86308445
119IMP metabolic process (GO:0046040)2.86301929
120regulation of helicase activity (GO:0051095)2.85861050
121negative regulation of histone methylation (GO:0031061)2.85404568
122otic vesicle formation (GO:0030916)2.85385089
123negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.85134415
124spliceosomal snRNP assembly (GO:0000387)2.84917031
125regulation of histone H3-K9 methylation (GO:0051570)2.83912801
126translational termination (GO:0006415)2.82564267
127mitotic spindle checkpoint (GO:0071174)2.81269508
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.81140237
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81140237
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81140237
131negative regulation of sister chromatid segregation (GO:0033046)2.81140237
132negative regulation of chromosome segregation (GO:0051985)2.80710780
133establishment of viral latency (GO:0019043)2.77107923
134negative chemotaxis (GO:0050919)2.76767338
135spinal cord association neuron differentiation (GO:0021527)2.76733462
136telomere maintenance via recombination (GO:0000722)2.76384605
137embryonic digestive tract morphogenesis (GO:0048557)2.76371068
138presynaptic membrane assembly (GO:0097105)2.76283451
139establishment of apical/basal cell polarity (GO:0035089)2.76215900
140regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74900732
141regulation of mitotic spindle checkpoint (GO:1903504)2.74900732
142signal transduction involved in regulation of gene expression (GO:0023019)2.74518562
143protein localization to chromosome (GO:0034502)2.74475297
144somite rostral/caudal axis specification (GO:0032525)2.74459703
145response to BMP (GO:0071772)2.74045504
146cellular response to BMP stimulus (GO:0071773)2.74045504
147placenta development (GO:0001890)2.73134853
148gastrulation with mouth forming second (GO:0001702)2.73064367
149neural crest cell development (GO:0014032)2.72772791
150regulation of double-strand break repair (GO:2000779)2.72493677
151regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.72421521
152digestive tract morphogenesis (GO:0048546)2.72310991
153negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71918801
154apical protein localization (GO:0045176)2.71691050
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.71389499
156spindle assembly checkpoint (GO:0071173)2.71234813
157bone trabecula formation (GO:0060346)2.71136727
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.69665067
159mitotic spindle assembly checkpoint (GO:0007094)2.69378699
160morphogenesis of an epithelial sheet (GO:0002011)2.69051894
161anterior/posterior axis specification, embryo (GO:0008595)2.68546682
162RNA splicing, via transesterification reactions (GO:0000375)2.67553722
163dosage compensation (GO:0007549)2.67140048
164primitive streak formation (GO:0090009)2.66436136
165regulation of centrosome duplication (GO:0010824)2.64576749
166establishment of tissue polarity (GO:0007164)2.63138497
167establishment of planar polarity (GO:0001736)2.63138497
168establishment of monopolar cell polarity (GO:0061162)2.62493508
169establishment or maintenance of monopolar cell polarity (GO:0061339)2.62493508
170mesenchymal to epithelial transition (GO:0060231)2.61373976
171kidney morphogenesis (GO:0060993)2.60903274
172olfactory bulb development (GO:0021772)2.60282723
173short-term memory (GO:0007614)2.59585645
174negative regulation of hormone biosynthetic process (GO:0032353)2.59487989
175mitotic chromosome condensation (GO:0007076)2.59243540
176positive regulation of cardiac muscle tissue development (GO:0055025)2.57943491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.78795352
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77897599
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.76726257
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.32728413
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.29479422
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.98740267
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.67346714
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.26831619
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82342785
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82045314
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74927767
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72169449
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72169449
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72169449
15AR_21909140_ChIP-Seq_LNCAP_Human2.64389494
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.47137180
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.37908364
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31138350
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20293349
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16831757
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.16308293
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.13877084
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12954540
24TTF2_22483619_ChIP-Seq_HELA_Human2.10319631
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09471265
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.06928479
27XRN2_22483619_ChIP-Seq_HELA_Human2.04243999
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00952199
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89447140
30TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88476811
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87969896
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87742670
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83277926
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.82037334
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76288750
36* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75046838
37TAF15_26573619_Chip-Seq_HEK293_Human1.73335278
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71742897
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70506965
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65740105
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64868856
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.63825230
43MYC_18940864_ChIP-ChIP_HL60_Human1.62160778
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61246290
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.60697580
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60618461
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57930311
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57851684
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56995237
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.55704108
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55290746
52EZH2_22144423_ChIP-Seq_EOC_Human1.54968528
53P300_19829295_ChIP-Seq_ESCs_Human1.49403556
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44624059
55ELK1_19687146_ChIP-ChIP_HELA_Human1.42246513
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40482924
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.36984850
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.36380107
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36145322
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.35888088
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35532317
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32385533
63IGF1R_20145208_ChIP-Seq_DFB_Human1.31338369
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30608965
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.29643104
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29439045
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.28955472
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28789409
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28029362
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25936158
71SOX9_26525672_Chip-Seq_HEART_Mouse1.24529131
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23965293
73FOXP3_21729870_ChIP-Seq_TREG_Human1.23637534
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22286712
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21902567
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21545055
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21545055
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20254676
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19301231
80IRF1_19129219_ChIP-ChIP_H3396_Human1.18722521
81EWS_26573619_Chip-Seq_HEK293_Human1.16666180
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15472292
83* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15158732
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14653384
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14168553
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13945517
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13773900
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12905015
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12416769
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11893218
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11883002
92MYC_22102868_ChIP-Seq_BL_Human1.11598369
93POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11428974
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10228967
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09665734
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09555064
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09405101
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09067070
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08874068
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08732781
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.08677544
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.08155320
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08116301
104* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07992492
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07234149
106TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06885153
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06709638
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06528442
109FUS_26573619_Chip-Seq_HEK293_Human1.05987965
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05775322
111VDR_23849224_ChIP-Seq_CD4+_Human1.04272166
112NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03312706
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01385992
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01230588
115SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01187912
116* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00944140
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00358617
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98298005
119* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96935665
120VDR_22108803_ChIP-Seq_LS180_Human0.96705698
121* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95431738
122EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95374073
123RNF2_27304074_Chip-Seq_NSC_Mouse0.94870343
124* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94622245
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.94138715
126GABP_17652178_ChIP-ChIP_JURKAT_Human0.93754539
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93547574
128* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92095963
129WT1_19549856_ChIP-ChIP_CCG9911_Human0.91827787
130* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91665247
131ZNF274_21170338_ChIP-Seq_K562_Hela0.91550531
132DCP1A_22483619_ChIP-Seq_HELA_Human0.88849189
133* ISL1_27105846_Chip-Seq_CPCs_Mouse0.87788870
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87699602
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86398819
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84894549
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84319060
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.83253257
139ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82909049
140* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81840649
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.81263634
142ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76656753
143NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75866652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.08747258
2MP0003123_paternal_imprinting3.48979568
3MP0006292_abnormal_olfactory_placode3.24626304
4MP0000566_synostosis2.93713536
5MP0010094_abnormal_chromosome_stability2.77912529
6MP0003693_abnormal_embryo_hatching2.74295111
7MP0008789_abnormal_olfactory_epithelium2.68190525
8MP0003890_abnormal_embryonic-extraembry2.64320579
9MP0002653_abnormal_ependyma_morphology2.63230947
10MP0003119_abnormal_digestive_system2.60239196
11MP0003121_genomic_imprinting2.57930868
12MP0004957_abnormal_blastocyst_morpholog2.44996516
13MP0003111_abnormal_nucleus_morphology2.38842479
14MP0003941_abnormal_skin_development2.38746673
15MP0004133_heterotaxia2.31200886
16MP0003878_abnormal_ear_physiology2.29166542
17MP0005377_hearing/vestibular/ear_phenot2.29166542
18MP0003077_abnormal_cell_cycle2.27865672
19MP0005499_abnormal_olfactory_system2.19145627
20MP0005394_taste/olfaction_phenotype2.19145627
21MP0001293_anophthalmia2.16736189
22MP0003122_maternal_imprinting2.15009938
23MP0008057_abnormal_DNA_replication2.14583165
24MP0000049_abnormal_middle_ear2.13520947
25MP0008932_abnormal_embryonic_tissue2.10137448
26MP0003937_abnormal_limbs/digits/tail_de2.08469980
27MP0009053_abnormal_anal_canal2.06275484
28MP0003315_abnormal_perineum_morphology1.99345542
29MP0009672_abnormal_birth_weight1.95674075
30MP0008877_abnormal_DNA_methylation1.94570901
31MP0008058_abnormal_DNA_repair1.92770432
32MP0008007_abnormal_cellular_replicative1.88233942
33MP0003938_abnormal_ear_development1.77241687
34MP0002938_white_spotting1.72495462
35MP0003385_abnormal_body_wall1.71158831
36MP0002084_abnormal_developmental_patter1.70770156
37MP0002085_abnormal_embryonic_tissue1.69133575
38MP0000778_abnormal_nervous_system1.68795546
39MP0002111_abnormal_tail_morphology1.68786447
40MP0002249_abnormal_larynx_morphology1.67916974
41MP0004197_abnormal_fetal_growth/weight/1.64683183
42MP0001730_embryonic_growth_arrest1.63756919
43MP0001672_abnormal_embryogenesis/_devel1.63606006
44MP0005380_embryogenesis_phenotype1.63606006
45MP0000537_abnormal_urethra_morphology1.62381140
46MP0005248_abnormal_Harderian_gland1.60962615
47MP0003880_abnormal_central_pattern1.55151571
48MP0000350_abnormal_cell_proliferation1.54109469
49MP0003567_abnormal_fetal_cardiomyocyte1.51260784
50MP0000516_abnormal_urinary_system1.50827150
51MP0005367_renal/urinary_system_phenotyp1.50827150
52MP0001299_abnormal_eye_distance/1.50679427
53MP0002233_abnormal_nose_morphology1.48341583
54MP0009379_abnormal_foot_pigmentation1.45625746
55MP0001286_abnormal_eye_development1.44265158
56MP0009703_decreased_birth_body1.42140185
57MP0001697_abnormal_embryo_size1.40273600
58MP0000432_abnormal_head_morphology1.37738387
59MP0003984_embryonic_growth_retardation1.33223028
60MP0003935_abnormal_craniofacial_develop1.32256897
61MP0003136_yellow_coat_color1.32221223
62MP0002088_abnormal_embryonic_growth/wei1.31998220
63MP0000428_abnormal_craniofacial_morphol1.31833101
64MP0002697_abnormal_eye_size1.29140042
65MP0003942_abnormal_urinary_system1.28989910
66MP0002751_abnormal_autonomic_nervous1.25239758
67MP0002932_abnormal_joint_morphology1.24625900
68MP0002638_abnormal_pupillary_reflex1.23002162
69MP0002092_abnormal_eye_morphology1.21203659
70MP0003861_abnormal_nervous_system1.20194057
71MP0002116_abnormal_craniofacial_bone1.18309303
72MP0003755_abnormal_palate_morphology1.17923433
73MP0000534_abnormal_ureter_morphology1.17269156
74MP0002177_abnormal_outer_ear1.17108236
75MP0002282_abnormal_trachea_morphology1.16221005
76MP0000631_abnormal_neuroendocrine_gland1.15332466
77MP0009250_abnormal_appendicular_skeleto1.11119989
78MP0002086_abnormal_extraembryonic_tissu1.07693830
79MP0002080_prenatal_lethality1.02518189
80MP0003115_abnormal_respiratory_system1.01752006
81MP0006054_spinal_hemorrhage0.97505022
82MP0000579_abnormal_nail_morphology0.96075889
83MP0002114_abnormal_axial_skeleton0.95971320
84MP0001915_intracranial_hemorrhage0.94838232
85MP0002160_abnormal_reproductive_system0.94024447
86MP0003786_premature_aging0.93595640
87MP0004858_abnormal_nervous_system0.89864084
88MP0002089_abnormal_postnatal_growth/wei0.89841239
89MP0000678_abnormal_parathyroid_gland0.88806146
90MP0002102_abnormal_ear_morphology0.86279309
91MP0002152_abnormal_brain_morphology0.86269813
92MP0005391_vision/eye_phenotype0.85466264
93MP0001188_hyperpigmentation0.83288722
94MP0005623_abnormal_meninges_morphology0.81840644
95MP0002234_abnormal_pharynx_morphology0.81726464
96MP0002127_abnormal_cardiovascular_syste0.81392968
97MP0005197_abnormal_uvea_morphology0.81233930
98MP0003283_abnormal_digestive_organ0.81219353
99MP0000313_abnormal_cell_death0.81132149
100MP0003787_abnormal_imprinting0.79620089
101MP0002210_abnormal_sex_determination0.79519856
102MP0000383_abnormal_hair_follicle0.79416403
103MP0001984_abnormal_olfaction0.78694806
104MP0005171_absent_coat_pigmentation0.78053202
105MP0003718_maternal_effect0.77519427
106MP0002081_perinatal_lethality0.77269987
107MP0001529_abnormal_vocalization0.76808170
108MP0000955_abnormal_spinal_cord0.76495717
109MP0002184_abnormal_innervation0.75932890
110MP0005195_abnormal_posterior_eye0.75837681
111MP0002109_abnormal_limb_morphology0.75514247
112MP0003950_abnormal_plasma_membrane0.74956511
113MP0005076_abnormal_cell_differentiation0.74430879
114MP0001485_abnormal_pinna_reflex0.73950734
115MP0001849_ear_inflammation0.73471109
116MP0001346_abnormal_lacrimal_gland0.72854899
117MP0001340_abnormal_eyelid_morphology0.72649106
118MP0002752_abnormal_somatic_nervous0.72178411
119MP0002098_abnormal_vibrissa_morphology0.72054597
120MP0000762_abnormal_tongue_morphology0.71431687
121MP0009697_abnormal_copulation0.70844981
122MP0002925_abnormal_cardiovascular_devel0.69529769
123MP0000026_abnormal_inner_ear0.69350066
124MP0001119_abnormal_female_reproductive0.68234518

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.89185463
2Rib fusion (HP:0000902)4.60137133
3Vitreoretinal degeneration (HP:0000655)4.20173014
4Partial duplication of thumb phalanx (HP:0009944)3.77730388
5Abnormal lung lobation (HP:0002101)3.51618633
6Abnormal number of incisors (HP:0011064)3.41480321
7Abnormality of the phalanges of the 2nd finger (HP:0009541)3.41355451
8Colon cancer (HP:0003003)3.22888648
9Supernumerary spleens (HP:0009799)3.20244160
10Abnormality of the anterior horn cell (HP:0006802)3.15517363
11Degeneration of anterior horn cells (HP:0002398)3.15517363
12Rectal fistula (HP:0100590)3.07372001
13Rectovaginal fistula (HP:0000143)3.07372001
14Absent septum pellucidum (HP:0001331)3.06393709
15Intestinal atresia (HP:0011100)3.03598940
16Abnormality of the septum pellucidum (HP:0007375)2.98369287
17Abnormality of the ischium (HP:0003174)2.97251442
18Nephroblastoma (Wilms tumor) (HP:0002667)2.89923968
19Duplication of thumb phalanx (HP:0009942)2.89696975
20Myelomeningocele (HP:0002475)2.85620720
21Abnormality of abdominal situs (HP:0011620)2.85354225
22Abdominal situs inversus (HP:0003363)2.85354225
23Impulsivity (HP:0100710)2.78670347
24Intestinal fistula (HP:0100819)2.75824236
25Embryonal renal neoplasm (HP:0011794)2.73901587
26Hypoplastic pelvis (HP:0008839)2.71828152
27Irregular epiphyses (HP:0010582)2.71656819
28Pseudobulbar signs (HP:0002200)2.70389776
29Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.63649444
30Hemivertebrae (HP:0002937)2.60245874
31Anal stenosis (HP:0002025)2.57447664
32Medulloblastoma (HP:0002885)2.57396525
33Anophthalmia (HP:0000528)2.56352482
34High anterior hairline (HP:0009890)2.55944175
35Absent radius (HP:0003974)2.55681864
36Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.54547699
37Hypoplastic ischia (HP:0003175)2.54458115
38Optic nerve hypoplasia (HP:0000609)2.53680979
39Trigonocephaly (HP:0000243)2.53139850
40Bifid tongue (HP:0010297)2.52334628
41Renal duplication (HP:0000075)2.52110908
42Stenosis of the external auditory canal (HP:0000402)2.51054930
43Growth hormone deficiency (HP:0000824)2.46881784
44Aplasia/Hypoplasia of the patella (HP:0006498)2.45793601
45Ectopic kidney (HP:0000086)2.45589188
46Midline defect of the nose (HP:0004122)2.44669376
47Renal hypoplasia (HP:0000089)2.43765399
48Vaginal fistula (HP:0004320)2.43307247
49Absent forearm bone (HP:0003953)2.42108371
50Aplasia involving forearm bones (HP:0009822)2.42108371
51Supernumerary ribs (HP:0005815)2.42048885
52Vertebral clefting (HP:0008428)2.41748760
53Cutaneous finger syndactyly (HP:0010554)2.41432825
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.41257631
55Coronal craniosynostosis (HP:0004440)2.39606983
56Hepatoblastoma (HP:0002884)2.37278253
57Aqueductal stenosis (HP:0002410)2.34706763
58Hypoplasia of the ulna (HP:0003022)2.34213091
59Abnormality of the phalanges of the 5th finger (HP:0004213)2.33944210
60Supernumerary bones of the axial skeleton (HP:0009144)2.32814230
61Short middle phalanx of finger (HP:0005819)2.32260269
62Abnormality of the nasal septum (HP:0000419)2.30451214
63Long eyelashes (HP:0000527)2.29808538
64Dysphonia (HP:0001618)2.29197345
65Missing ribs (HP:0000921)2.28355669
66Aplasia/hypoplasia of the humerus (HP:0006507)2.27958088
67Cutaneous syndactyly (HP:0012725)2.27163031
68Abnormality of the phalanges of the hallux (HP:0010057)2.25981622
69Abnormality of the ileum (HP:0001549)2.23053329
70Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.22165844
71Short 1st metacarpal (HP:0010034)2.22165844
72Mixed hearing impairment (HP:0000410)2.22141105
73Broad phalanx (HP:0006009)2.19846692
74Vertebral fusion (HP:0002948)2.19539680
75Abnormality of the nasolacrimal system (HP:0000614)2.19279710
76Short humerus (HP:0005792)2.17911061
77Abnormality of the lacrimal duct (HP:0011481)2.17876294
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17302286
79Short 4th metacarpal (HP:0010044)2.17302286
80Absent eyebrow (HP:0002223)2.16745300
81Thin ribs (HP:0000883)2.16271161
82Patellar aplasia (HP:0006443)2.16102463
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.15909419
84Selective tooth agenesis (HP:0001592)2.14614560
85Proximal placement of thumb (HP:0009623)2.13611926
86Abnormality of the middle phalanges of the toes (HP:0010183)2.13136676
87Abnormality of the lumbar spine (HP:0100712)2.13032780
88Chromsome breakage (HP:0040012)2.12500022
89Synostosis of carpal bones (HP:0005048)2.10789851
90Bilateral microphthalmos (HP:0007633)2.09931691
91Broad thumb (HP:0011304)2.08647913
92Abnormality of the parietal bone (HP:0002696)2.08625193
93Oligodactyly (hands) (HP:0001180)2.08226678
94Deviation of the thumb (HP:0009603)2.08122481
95Broad palm (HP:0001169)2.07408664
96Broad long bones (HP:0005622)2.05769055
97Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05459644
98Abnormality of the 2nd finger (HP:0004100)2.05274835
99Preaxial foot polydactyly (HP:0001841)2.04975724
100Abnormal vertebral ossification (HP:0100569)2.04968606
101Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04384237
102Absent epiphyses (HP:0010577)2.04384237
103Reticulocytopenia (HP:0001896)2.04203634
104Tracheomalacia (HP:0002779)2.03798339
105Birth length less than 3rd percentile (HP:0003561)2.02647143
106Morphological abnormality of the middle ear (HP:0008609)2.02600800
107Abnormality of the incisor (HP:0000676)2.01733841
108Esophageal atresia (HP:0002032)2.00805762
109Gastrointestinal atresia (HP:0002589)1.99063596
110Short hallux (HP:0010109)1.98915880
111Abnormality of the 4th metacarpal (HP:0010012)1.98709943
112Partial duplication of the phalanx of hand (HP:0009999)1.98593948
113Atresia of the external auditory canal (HP:0000413)1.97352796
114Abnormality of the pubic bones (HP:0003172)1.95962114
115Skull defect (HP:0001362)1.95935266
116Abnormality of the aortic arch (HP:0012303)1.95416008
117Shawl scrotum (HP:0000049)1.95229979
118Diastasis recti (HP:0001540)1.94806354
119Abnormality of the proximal phalanges of the hand (HP:0009834)1.94405378
120Maternal diabetes (HP:0009800)1.93441797
121Omphalocele (HP:0001539)1.92901251
122Split foot (HP:0001839)1.92489128
123Meckel diverticulum (HP:0002245)1.92374595
124Cerebellar dysplasia (HP:0007033)1.92237714
125Fused cervical vertebrae (HP:0002949)1.91999661
126Carpal synostosis (HP:0009702)1.91691416
127Aplasia/Hypoplasia of the ulna (HP:0006495)1.90503565
128Degeneration of the lateral corticospinal tracts (HP:0002314)1.90096953
129Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90096953
130Aplasia involving bones of the extremities (HP:0009825)1.89607091
131Aplasia involving bones of the upper limbs (HP:0009823)1.89607091
132Aplasia of the phalanges of the hand (HP:0009802)1.89607091
133Broad toe (HP:0001837)1.88755804
134Abnormality of the 1st metacarpal (HP:0010009)1.88336579
135Hypoplastic labia majora (HP:0000059)1.87620686
136Absent thumb (HP:0009777)1.87425438
137Choanal stenosis (HP:0000452)1.87355519
138Bicornuate uterus (HP:0000813)1.87097357
139Renal dysplasia (HP:0000110)1.86496357
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.86294591
141Broad finger (HP:0001500)1.86153258
142Anal atresia (HP:0002023)1.85681892
143Increased number of teeth (HP:0011069)1.85103511
144Triphalangeal thumb (HP:0001199)1.84856231
145Short middle phalanx of the 5th finger (HP:0004220)1.84112313
146Short phalanx of the thumb (HP:0009660)1.83934132
147Disproportionate short-trunk short stature (HP:0003521)1.83759542
148Oligodactyly (HP:0012165)1.83496881
149Broad phalanges of the hand (HP:0009768)1.83472345
150Delayed epiphyseal ossification (HP:0002663)1.83417504
151Neonatal short-limb short stature (HP:0008921)1.82746792
152Abnormality of the labia majora (HP:0012881)1.82548796
153Volvulus (HP:0002580)1.82482554
154Asplenia (HP:0001746)1.79972481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK15.57853188
2CDC75.03303535
3MKNK24.42274838
4EPHA44.03536931
5SRPK13.82450708
6FGFR23.36148316
7EIF2AK22.66903898
8PLK42.64395745
9CDK122.49381256
10WEE12.40259590
11PASK2.17634838
12PLK32.11003480
13BUB12.10791208
14PNCK2.09595444
15WNK32.04426301
16BRD42.02175201
17TAF12.00945277
18PKN21.98247675
19NEK21.95022728
20TTK1.91883355
21VRK21.74506148
22TYRO31.73151641
23TRIM281.70085522
24EPHB21.69730875
25PLK11.68194924
26FLT31.60144111
27MAP3K41.57444676
28ZAK1.56787141
29TSSK61.55552008
30BMPR1B1.53459060
31LATS21.53261760
32PDGFRA1.45011803
33EIF2AK11.43818153
34AURKA1.39661542
35TLK11.38910123
36CHEK11.36158525
37CHEK21.35489678
38AURKB1.33515693
39ERBB31.32816869
40CDK71.30570521
41ATR1.27581254
42STK41.17517353
43CLK11.16638670
44CASK1.15683257
45PIK3CA1.12557698
46STK38L1.10892563
47ACVR1B1.09985230
48EIF2AK31.05978903
49MAP3K81.02649572
50VRK11.01842191
51CDK60.98776665
52TGFBR10.98565762
53ATM0.98475365
54CDK20.96872470
55PLK20.96756075
56NTRK20.96233615
57CDK40.89276373
58NUAK10.87904050
59FGFR10.85560468
60OBSCN0.81434192
61ALK0.79655033
62CDK10.79117001
63MAP2K70.77652449
64CSNK2A20.74659354
65YES10.73597540
66MAP2K30.73386795
67AKT30.72931605
68NLK0.72408434
69KSR10.72198353
70CSNK1E0.72108724
71RPS6KB20.72064680
72BRSK20.70559825
73PIM10.70340539
74MELK0.70244284
75MAP3K100.70158067
76TIE10.65293575
77CSNK2A10.65098064
78BCR0.64214295
79RPS6KA40.61849992
80STK100.60846201
81TNIK0.59830263
82STK30.58568675
83ERBB20.58555268
84PAK40.58470374
85PBK0.57940174
86ICK0.56377817
87AKT10.55558838
88CDK30.55545831
89STK160.55010922
90CDK190.54599769
91PRKDC0.53866595
92MTOR0.53187004
93LATS10.53073130
94CSNK1D0.52122667
95MAPK140.52075016
96BRAF0.51746606
97NEK10.50081490
98DYRK1A0.46303424
99PAK10.45623172
100PDGFRB0.44845408
101STK240.44544942
102PAK20.43655338
103PRKCG0.43459359
104MAP2K40.41287027
105BMX0.39857272
106BRSK10.36666820
107CDK180.35867265
108STK110.34046286
109NTRK10.33656927
110CSNK1G30.33551807
111GSK3B0.33432328
112UHMK10.32817630
113AKT20.32267399
114DYRK20.32256789
115PTK60.32011213
116DYRK30.31521118
117CSNK1G10.30594720
118CDK150.30502944
119CDK11A0.30210638
120EPHA20.29365867
121CSNK1A1L0.27335944
122MINK10.26870460
123MAPK10.26554001
124NEK90.25893845
125DYRK1B0.25739198
126RPS6KA50.24884374
127MAP2K60.24795307
128CAMK1G0.23595725
129MAP2K20.23392599
130FGR0.21884433
131CAMK1D0.21409867
132SGK20.21238235
133CDK80.21014360
134MAPK100.19675985
135PRKD30.19442975

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43317399
2Mismatch repair_Homo sapiens_hsa034304.35177186
3Spliceosome_Homo sapiens_hsa030403.81533147
4Homologous recombination_Homo sapiens_hsa034403.24246515
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21578333
6Cell cycle_Homo sapiens_hsa041103.04744687
7RNA transport_Homo sapiens_hsa030132.95914630
8One carbon pool by folate_Homo sapiens_hsa006702.85892244
9Basal cell carcinoma_Homo sapiens_hsa052172.73416186
10Ribosome_Homo sapiens_hsa030102.64880811
11Base excision repair_Homo sapiens_hsa034102.60142797
12Nucleotide excision repair_Homo sapiens_hsa034202.54974127
13mRNA surveillance pathway_Homo sapiens_hsa030152.45069865
14Fanconi anemia pathway_Homo sapiens_hsa034602.43765129
15Non-homologous end-joining_Homo sapiens_hsa034502.38777886
16RNA polymerase_Homo sapiens_hsa030202.35395681
17Basal transcription factors_Homo sapiens_hsa030222.27380491
18RNA degradation_Homo sapiens_hsa030182.14172481
19Systemic lupus erythematosus_Homo sapiens_hsa053221.97263424
20Hedgehog signaling pathway_Homo sapiens_hsa043401.88491879
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86720714
22Proteasome_Homo sapiens_hsa030501.78933116
23Hippo signaling pathway_Homo sapiens_hsa043901.77696672
24Pyrimidine metabolism_Homo sapiens_hsa002401.66113282
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.54408565
26Wnt signaling pathway_Homo sapiens_hsa043101.50101207
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48845673
28p53 signaling pathway_Homo sapiens_hsa041151.48294386
29Oocyte meiosis_Homo sapiens_hsa041141.48015219
30Adherens junction_Homo sapiens_hsa045201.45021942
31Thyroid cancer_Homo sapiens_hsa052161.37824925
32MicroRNAs in cancer_Homo sapiens_hsa052061.36579347
33ECM-receptor interaction_Homo sapiens_hsa045121.34830331
34Notch signaling pathway_Homo sapiens_hsa043301.33255544
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23037423
36TGF-beta signaling pathway_Homo sapiens_hsa043501.21270108
37Protein export_Homo sapiens_hsa030601.20509393
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14940025
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06128377
40Purine metabolism_Homo sapiens_hsa002301.01320814
41Melanogenesis_Homo sapiens_hsa049160.96895688
42Alcoholism_Homo sapiens_hsa050340.96680928
43Herpes simplex infection_Homo sapiens_hsa051680.95010064
44Propanoate metabolism_Homo sapiens_hsa006400.93811989
45HTLV-I infection_Homo sapiens_hsa051660.92897200
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90035013
47Viral carcinogenesis_Homo sapiens_hsa052030.89515668
48Protein digestion and absorption_Homo sapiens_hsa049740.84714700
49Tight junction_Homo sapiens_hsa045300.84673867
50Selenocompound metabolism_Homo sapiens_hsa004500.82343366
51Epstein-Barr virus infection_Homo sapiens_hsa051690.80629796
52Pathways in cancer_Homo sapiens_hsa052000.75016614
53Lysine degradation_Homo sapiens_hsa003100.72683415
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67873429
55Small cell lung cancer_Homo sapiens_hsa052220.64846214
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62173562
57Colorectal cancer_Homo sapiens_hsa052100.62159508
58Parkinsons disease_Homo sapiens_hsa050120.60653844
59Nitrogen metabolism_Homo sapiens_hsa009100.59427694
60Folate biosynthesis_Homo sapiens_hsa007900.57421857
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57287159
62Prostate cancer_Homo sapiens_hsa052150.56674630
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54100525
64Oxidative phosphorylation_Homo sapiens_hsa001900.53729114
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52881476
66Endometrial cancer_Homo sapiens_hsa052130.51301153
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48045546
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47460932
69Axon guidance_Homo sapiens_hsa043600.46848431
70Pyruvate metabolism_Homo sapiens_hsa006200.45674073
71Prion diseases_Homo sapiens_hsa050200.43919193
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.43176759
73Melanoma_Homo sapiens_hsa052180.42900603
74Proteoglycans in cancer_Homo sapiens_hsa052050.42673543
75Antigen processing and presentation_Homo sapiens_hsa046120.42530018
76Viral myocarditis_Homo sapiens_hsa054160.41315750
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40283858
78Focal adhesion_Homo sapiens_hsa045100.39085789
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.37893433
80Phototransduction_Homo sapiens_hsa047440.37130894
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36743765
82Huntingtons disease_Homo sapiens_hsa050160.35943158
83Biosynthesis of amino acids_Homo sapiens_hsa012300.34499131
84Choline metabolism in cancer_Homo sapiens_hsa052310.32015056
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31391194
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29793661
87Tyrosine metabolism_Homo sapiens_hsa003500.29466732
88Glycerolipid metabolism_Homo sapiens_hsa005610.28442631
89Gap junction_Homo sapiens_hsa045400.27271890
90Retinol metabolism_Homo sapiens_hsa008300.25824885
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25452304
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24945308
93Bladder cancer_Homo sapiens_hsa052190.24698318
94FoxO signaling pathway_Homo sapiens_hsa040680.23738634
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21370591
96Glutathione metabolism_Homo sapiens_hsa004800.20517102
97HIF-1 signaling pathway_Homo sapiens_hsa040660.19984468
98Alzheimers disease_Homo sapiens_hsa050100.19398719
99Thyroid hormone synthesis_Homo sapiens_hsa049180.18638476
100Dilated cardiomyopathy_Homo sapiens_hsa054140.18547958
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18212407
102Rap1 signaling pathway_Homo sapiens_hsa040150.16864487
103Nicotine addiction_Homo sapiens_hsa050330.16190479
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15711414
105Metabolic pathways_Homo sapiens_hsa011000.15511049
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15098278
107Taste transduction_Homo sapiens_hsa047420.14432995
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13220412
109Steroid biosynthesis_Homo sapiens_hsa001000.12805660
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12359328
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10648957
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08973312
113Glucagon signaling pathway_Homo sapiens_hsa049220.08828033
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07806260
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.07487716
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07319154
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.06391435
118Phenylalanine metabolism_Homo sapiens_hsa003600.04477698
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02988732
120Cardiac muscle contraction_Homo sapiens_hsa042600.02856033
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02732038
122Arachidonic acid metabolism_Homo sapiens_hsa005900.01864536
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.01584201
124Legionellosis_Homo sapiens_hsa051340.01296085
125Chronic myeloid leukemia_Homo sapiens_hsa052200.01072610
126Asthma_Homo sapiens_hsa05310-0.0301386
127Graft-versus-host disease_Homo sapiens_hsa05332-0.0246952
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0185748
129Hepatitis B_Homo sapiens_hsa05161-0.0179811
130N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0115601

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