ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular ketone body metabolic process (GO:0046950)	6.68805874
2	ketone body metabolic process (GO:1902224)	5.91730525
3	inositol phosphate catabolic process (GO:0071545)	5.62183296
4	indolalkylamine metabolic process (GO:0006586)	4.96067748
5	inositol phosphate dephosphorylation (GO:0046855)	4.94703389
6	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.94703389
7	sequestering of actin monomers (GO:0042989)	4.65608374
8	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.38117482
9	GMP metabolic process (GO:0046037)	4.10004689
10	respiratory chain complex IV assembly (GO:0008535)	4.09525755
11	protein-cofactor linkage (GO:0018065)	3.99327760
12	polyol catabolic process (GO:0046174)	3.97293109
13	heme transport (GO:0015886)	3.92797996
14	cytochrome complex assembly (GO:0017004)	3.90003979
15	negative regulation of response to food (GO:0032096)	3.89200591
16	negative regulation of appetite (GO:0032099)	3.89200591
17	heparin biosynthetic process (GO:0030210)	3.80672923
18	heparin metabolic process (GO:0030202)	3.80672923
19	protein prenylation (GO:0018342)	3.74002875
20	prenylation (GO:0097354)	3.74002875
21	axoneme assembly (GO:0035082)	3.66101377
22	amino acid salvage (GO:0043102)	3.64823041
23	L-methionine salvage (GO:0071267)	3.64823041
24	L-methionine biosynthetic process (GO:0071265)	3.64823041
25	proline transport (GO:0015824)	3.61702955
26	C4-dicarboxylate transport (GO:0015740)	3.57603593
27	somite rostral/caudal axis specification (GO:0032525)	3.51112665
28	regulation of glucokinase activity (GO:0033131)	3.48867412
29	regulation of hexokinase activity (GO:1903299)	3.48867412
30	neural tube formation (GO:0001841)	3.45086771
31	protein localization to Golgi apparatus (GO:0034067)	3.44636728
32	protein targeting to Golgi (GO:0000042)	3.38144623
33	inner mitochondrial membrane organization (GO:0007007)	3.34859673
34	serotonin metabolic process (GO:0042428)	3.27524844
35	beta-amyloid metabolic process (GO:0050435)	3.27052039
36	indole-containing compound metabolic process (GO:0042430)	3.26349716
37	preassembly of GPI anchor in ER membrane (GO:0016254)	3.23612068
38	establishment of protein localization to Golgi (GO:0072600)	3.18587326
39	protein complex biogenesis (GO:0070271)	3.17804568
40	leukotriene biosynthetic process (GO:0019370)	3.08373333
41	negative regulation of execution phase of apoptosis (GO:1900118)	3.07736745
42	tryptophan metabolic process (GO:0006568)	3.06395196
43	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.06316596
44	DNA deamination (GO:0045006)	3.03743746
45	negative regulation of telomere maintenance (GO:0032205)	3.02679066
46	negative regulation of dendrite development (GO:2000171)	3.02549763
47	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.01897873
48	glycerophospholipid catabolic process (GO:0046475)	3.00932755
49	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.98809876
50	regulation of appetite (GO:0032098)	2.98191281
51	L-fucose catabolic process (GO:0042355)	2.93674457
52	fucose catabolic process (GO:0019317)	2.93674457
53	L-fucose metabolic process (GO:0042354)	2.93674457
54	alanine transport (GO:0032328)	2.92923649
55	negative regulation of meiosis (GO:0045835)	2.91743613
56	urate metabolic process (GO:0046415)	2.91523112
57	primary amino compound metabolic process (GO:1901160)	2.86695425
58	C21-steroid hormone biosynthetic process (GO:0006700)	2.85294781
59	endocrine pancreas development (GO:0031018)	2.83362768
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.83101406
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.82869272
62	regulation of telomere maintenance via telomerase (GO:0032210)	2.81728303
63	protein neddylation (GO:0045116)	2.80812372
64	cysteine metabolic process (GO:0006534)	2.79256593
65	branched-chain amino acid catabolic process (GO:0009083)	2.75405824
66	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.73591062
67	response to pheromone (GO:0019236)	2.72040539
68	neuronal action potential (GO:0019228)	2.71068726
69	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69096803
70	iron coordination entity transport (GO:1901678)	2.67981258
71	regulation of response to food (GO:0032095)	2.67062321
72	meiotic chromosome segregation (GO:0045132)	2.67058704
73	epithelial cell fate commitment (GO:0072148)	2.64360552
74	retinal cone cell development (GO:0046549)	2.63638360
75	insulin secretion (GO:0030073)	2.62648625
76	methionine biosynthetic process (GO:0009086)	2.62461357
77	mitochondrial DNA replication (GO:0006264)	2.62028631
78	regulation of mitotic spindle organization (GO:0060236)	2.61858987
79	negative regulation of meiotic cell cycle (GO:0051447)	2.61323059
80	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.58931591
81	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.58189591
82	nitric oxide mediated signal transduction (GO:0007263)	2.58104269
83	positive regulation of amino acid transport (GO:0051957)	2.56192575
84	indolalkylamine catabolic process (GO:0046218)	2.55538523
85	tryptophan catabolic process (GO:0006569)	2.55538523
86	indole-containing compound catabolic process (GO:0042436)	2.55538523
87	glycosphingolipid biosynthetic process (GO:0006688)	2.54879727
88	platelet dense granule organization (GO:0060155)	2.54763177
89	synapsis (GO:0007129)	2.53078811
90	negative regulation of neurological system process (GO:0031645)	2.51385237
91	sulfur amino acid biosynthetic process (GO:0000097)	2.51066062
92	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.48706564
93	negative regulation of T-helper cell differentiation (GO:0045623)	2.48706564
94	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.48361416
95	positive regulation of histone H3-K4 methylation (GO:0051571)	2.46929893
96	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.46079138
97	ATP synthesis coupled proton transport (GO:0015986)	2.46079138
98	adult feeding behavior (GO:0008343)	2.46005327
99	ATP hydrolysis coupled proton transport (GO:0015991)	2.42910582
100	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.42910582

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.67320246
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.62638946
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.99901616
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97984885
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.95810338
6	VDR_22108803_ChIP-Seq_LS180_Human	2.91401192
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.77763913
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.76180002
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63590673
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.55403311
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17368835
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14370266
13	P300_19829295_ChIP-Seq_ESCs_Human	2.09721058
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07485288
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94553661
16	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.88880879
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.83839128
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76194350
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75627437
20	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.75514157
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.72363979
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.70564718
23	EWS_26573619_Chip-Seq_HEK293_Human	1.68803187
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67593807
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63624204
26	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.63016517
27	FUS_26573619_Chip-Seq_HEK293_Human	1.60154860
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55712827
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55244554
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49685133
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46641608
32	AR_25329375_ChIP-Seq_VCAP_Human	1.45696956
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41862539
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38710694
35	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38687565
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.38386212
37	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.38074820
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37896798
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37896798
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.37835602
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36407724
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.35664239
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34561888
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34561888
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33401036
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32806843
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.32781286
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32781286
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31495344
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26910165
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24784109
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24723064
53	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.24659852
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.24432663
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24386380
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24059063
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22583203
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21715761
59	STAT3_23295773_ChIP-Seq_U87_Human	1.20922111
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18914345
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.18661502
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.17699481
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17082306
64	TCF4_23295773_ChIP-Seq_U87_Human	1.16959184
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16139137
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15265688
67	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15066254
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14924534
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12396964
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12225140
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.11713407
72	VDR_23849224_ChIP-Seq_CD4+_Human	1.10619045
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10567810
74	NCOR_22424771_ChIP-Seq_293T_Human	1.09158191
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.08363257
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07528096
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05941401
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05465627
79	TP53_16413492_ChIP-PET_HCT116_Human	1.04926627
80	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04494831
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03905049
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03856354
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03177417
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02775423
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02769348
86	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.02198197
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01378473
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00939078
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99602069
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99249012
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98138391
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97776395
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97743538
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97669165
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97409322
96	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97123118
97	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97080160
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97061106
99	AR_20517297_ChIP-Seq_VCAP_Human	0.96621343
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96419204

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.94891361
2	MP0005645_abnormal_hypothalamus_physiol	3.41032965
3	MP0003011_delayed_dark_adaptation	3.34297376
4	MP0008877_abnormal_DNA_methylation	3.22179590
5	MP0001984_abnormal_olfaction	2.85165645
6	MP0002102_abnormal_ear_morphology	2.84086116
7	MP0005451_abnormal_body_composition	2.82251949
8	MP0006072_abnormal_retinal_apoptosis	2.57016865
9	MP0003787_abnormal_imprinting	2.47488922
10	MP0002736_abnormal_nociception_after	2.41199155
11	MP0000372_irregular_coat_pigmentation	2.39605440
12	MP0005253_abnormal_eye_physiology	2.36606854
13	MP0009046_muscle_twitch	2.34612148
14	MP0005408_hypopigmentation	2.28864892
15	MP0002909_abnormal_adrenal_gland	2.26069723
16	MP0003122_maternal_imprinting	2.24319247
17	MP0004147_increased_porphyrin_level	2.21682956
18	MP0005085_abnormal_gallbladder_physiolo	2.13596557
19	MP0001968_abnormal_touch/_nociception	2.10023646
20	MP0002837_dystrophic_cardiac_calcinosis	2.07945636
21	MP0009697_abnormal_copulation	2.00040864
22	MP0003195_calcinosis	1.98101280
23	MP0003880_abnormal_central_pattern	1.90864625
24	MP0000015_abnormal_ear_pigmentation	1.87819951
25	MP0000631_abnormal_neuroendocrine_gland	1.79759349
26	MP0000516_abnormal_urinary_system	1.76264589
27	MP0005367_renal/urinary_system_phenotyp	1.76264589
28	MP0008872_abnormal_physiological_respon	1.69914000
29	MP0010386_abnormal_urinary_bladder	1.69224283
30	MP0000013_abnormal_adipose_tissue	1.65631229
31	MP0005551_abnormal_eye_electrophysiolog	1.63840497
32	MP0008058_abnormal_DNA_repair	1.57801180
33	MP0001188_hyperpigmentation	1.56383952
34	MP0008875_abnormal_xenobiotic_pharmacok	1.53976387
35	MP0005646_abnormal_pituitary_gland	1.53286481
36	MP0001970_abnormal_pain_threshold	1.51858456
37	MP0002272_abnormal_nervous_system	1.43858000
38	MP0009745_abnormal_behavioral_response	1.38341055
39	MP0001764_abnormal_homeostasis	1.35248912
40	MP0002295_abnormal_pulmonary_circulatio	1.33126463
41	MP0001905_abnormal_dopamine_level	1.32648929
42	MP0006276_abnormal_autonomic_nervous	1.32102603
43	MP0004270_analgesia	1.31229048
44	MP0002876_abnormal_thyroid_physiology	1.31045944
45	MP0003137_abnormal_impulse_conducting	1.28799657
46	MP0006292_abnormal_olfactory_placode	1.28435999
47	MP0008995_early_reproductive_senescence	1.27896512
48	MP0002064_seizures	1.27830995
49	MP0001986_abnormal_taste_sensitivity	1.27254535
50	MP0005379_endocrine/exocrine_gland_phen	1.24560362
51	MP0002693_abnormal_pancreas_physiology	1.24137365
52	MP0002938_white_spotting	1.23637416
53	MP0005220_abnormal_exocrine_pancreas	1.22929324
54	MP0002733_abnormal_thermal_nociception	1.22106644
55	MP0002734_abnormal_mechanical_nocicepti	1.20679863
56	MP0003121_genomic_imprinting	1.19484600
57	MP0004215_abnormal_myocardial_fiber	1.19213035
58	MP0002163_abnormal_gland_morphology	1.17020956
59	MP0005535_abnormal_body_temperature	1.16741547
60	MP0002638_abnormal_pupillary_reflex	1.16185502
61	MP0008775_abnormal_heart_ventricle	1.15081189
62	MP0001944_abnormal_pancreas_morphology	1.13138927
63	MP0005171_absent_coat_pigmentation	1.13029708
64	MP0004019_abnormal_vitamin_homeostasis	1.12265302
65	MP0002090_abnormal_vision	1.10947983
66	MP0004142_abnormal_muscle_tone	1.09119653
67	MP0002078_abnormal_glucose_homeostasis	1.05596760
68	MP0000639_abnormal_adrenal_gland	1.05318280
69	MP0001501_abnormal_sleep_pattern	1.02589407
70	MP0004085_abnormal_heartbeat	1.02470515
71	MP0005075_abnormal_melanosome_morpholog	1.00077631
72	MP0005448_abnormal_energy_balance	0.97545147
73	MP0005647_abnormal_sex_gland	0.92917578
74	MP0009764_decreased_sensitivity_to	0.92697600
75	MP0005174_abnormal_tail_pigmentation	0.90068310
76	MP0002572_abnormal_emotion/affect_behav	0.89578151
77	MP0004885_abnormal_endolymph	0.89351853
78	MP0002751_abnormal_autonomic_nervous	0.88826626
79	MP0003953_abnormal_hormone_level	0.86644022
80	MP0000427_abnormal_hair_cycle	0.86616580
81	MP0010329_abnormal_lipoprotein_level	0.86329327
82	MP0003638_abnormal_response/metabolism_	0.85225145
83	MP0006036_abnormal_mitochondrial_physio	0.84796409
84	MP0001529_abnormal_vocalization	0.84109478
85	MP0002254_reproductive_system_inflammat	0.83533520
86	MP0000538_abnormal_urinary_bladder	0.82727563
87	MP0003183_abnormal_peptide_metabolism	0.82627737
88	MP0003172_abnormal_lysosome_physiology	0.82560152
89	MP0003119_abnormal_digestive_system	0.81011984
90	MP0005391_vision/eye_phenotype	0.80486816
91	MP0005332_abnormal_amino_acid	0.79269235
92	MP0001727_abnormal_embryo_implantation	0.78064117
93	MP0006035_abnormal_mitochondrial_morpho	0.76250697
94	MP0002822_catalepsy	0.76051308
95	MP0002928_abnormal_bile_duct	0.72806502
96	MP0002063_abnormal_learning/memory/cond	0.71861403
97	MP0003786_premature_aging	0.71292716
98	MP0002139_abnormal_hepatobiliary_system	0.71024268
99	MP0000371_diluted_coat_color	0.70247519
100	MP0005195_abnormal_posterior_eye	0.69584410

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	5.38566996
2	Hypoglycemic coma (HP:0001325)	5.10323309
3	Tongue fasciculations (HP:0001308)	3.80523133
4	Neoplasm of the adrenal cortex (HP:0100641)	3.69781462
5	Generalized aminoaciduria (HP:0002909)	3.57566584
6	Adrenal hypoplasia (HP:0000835)	3.47023370
7	Pancreatic cysts (HP:0001737)	3.35297828
8	Muscle fibrillation (HP:0010546)	3.22764844
9	Spinal muscular atrophy (HP:0007269)	3.18013913
10	Hepatic necrosis (HP:0002605)	3.10107216
11	Degeneration of anterior horn cells (HP:0002398)	2.96249463
12	Abnormality of the anterior horn cell (HP:0006802)	2.96249463
13	Renal cortical cysts (HP:0000803)	2.93511666
14	Abnormality of the labia minora (HP:0012880)	2.90115974
15	Cutaneous melanoma (HP:0012056)	2.88219228
16	Decreased central vision (HP:0007663)	2.86917631
17	Hypoglycemic seizures (HP:0002173)	2.83699457
18	Type II lissencephaly (HP:0007260)	2.81174883
19	Abnormality of the renal cortex (HP:0011035)	2.69771710
20	Septo-optic dysplasia (HP:0100842)	2.68740323
21	3-Methylglutaconic aciduria (HP:0003535)	2.68708997
22	Limb dystonia (HP:0002451)	2.67722644
23	Progressive microcephaly (HP:0000253)	2.66748415
24	Neoplasm of the adrenal gland (HP:0100631)	2.66580509
25	Broad alveolar ridges (HP:0000187)	2.63391758
26	Stomach cancer (HP:0012126)	2.63290904
27	Increased corneal curvature (HP:0100692)	2.62384774
28	Keratoconus (HP:0000563)	2.62384774
29	Optic nerve hypoplasia (HP:0000609)	2.51019373
30	Unilateral renal agenesis (HP:0000122)	2.48290175
31	Pancreatic fibrosis (HP:0100732)	2.43548079
32	Abnormal pancreas size (HP:0012094)	2.41018403
33	Symptomatic seizures (HP:0011145)	2.39712895
34	Spastic tetraplegia (HP:0002510)	2.38729554
35	Medial flaring of the eyebrow (HP:0010747)	2.37025335
36	True hermaphroditism (HP:0010459)	2.34025561
37	Pachygyria (HP:0001302)	2.33092836
38	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31711954
39	Abnormality of the pancreatic islet cells (HP:0006476)	2.30425620
40	Abnormality of endocrine pancreas physiology (HP:0012093)	2.30425620
41	Polyphagia (HP:0002591)	2.29955606
42	Stomatitis (HP:0010280)	2.29434957
43	Severe visual impairment (HP:0001141)	2.27510393
44	Gait imbalance (HP:0002141)	2.25461659
45	Intellectual disability, profound (HP:0002187)	2.25386115
46	Pendular nystagmus (HP:0012043)	2.25150317
47	Congenital, generalized hypertrichosis (HP:0004540)	2.23752481
48	Generalized myoclonic seizures (HP:0002123)	2.22597165
49	Ketoacidosis (HP:0001993)	2.21930750
50	Methylmalonic acidemia (HP:0002912)	2.20353640
51	Hyperinsulinemic hypoglycemia (HP:0000825)	2.19952115
52	Attenuation of retinal blood vessels (HP:0007843)	2.19154730
53	Carpal bone hypoplasia (HP:0001498)	2.19080001
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.17648389
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.17648389
56	Congenital primary aphakia (HP:0007707)	2.13949013
57	Abnormal hair whorl (HP:0010721)	2.12449406
58	Abnormality of vitamin B metabolism (HP:0004340)	2.11665247
59	Absent speech (HP:0001344)	2.10805069
60	Abnormality of macular pigmentation (HP:0008002)	2.10579905
61	Nephronophthisis (HP:0000090)	2.09601573
62	Hyperventilation (HP:0002883)	2.09588818
63	Severe muscular hypotonia (HP:0006829)	2.05014845
64	Glioma (HP:0009733)	2.04986218
65	Facial diplegia (HP:0001349)	2.02990252
66	Increased CSF lactate (HP:0002490)	2.02163669
67	Chronic hepatic failure (HP:0100626)	1.99224499
68	Poor suck (HP:0002033)	1.98648862
69	Hemiparesis (HP:0001269)	1.95951040
70	Proximal tubulopathy (HP:0000114)	1.93546760
71	Abnormality of urine glucose concentration (HP:0011016)	1.93365500
72	Glycosuria (HP:0003076)	1.93365500
73	Progressive macrocephaly (HP:0004481)	1.93101289
74	Abnormality of the fovea (HP:0000493)	1.92877386
75	Exocrine pancreatic insufficiency (HP:0001738)	1.92703483
76	Lissencephaly (HP:0001339)	1.92004077
77	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91429467
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89853742
79	Mitochondrial inheritance (HP:0001427)	1.89760598
80	Abolished electroretinogram (ERG) (HP:0000550)	1.88144233
81	Aqueductal stenosis (HP:0002410)	1.87857567
82	Homocystinuria (HP:0002156)	1.85710573
83	Abnormality of homocysteine metabolism (HP:0010919)	1.85710573
84	Hepatocellular necrosis (HP:0001404)	1.85074544
85	Cystic liver disease (HP:0006706)	1.84223110
86	Oligomenorrhea (HP:0000876)	1.83731089
87	Abnormality of the periventricular white matter (HP:0002518)	1.82696813
88	Nephrogenic diabetes insipidus (HP:0009806)	1.82032686
89	Large for gestational age (HP:0001520)	1.79687338
90	Scrotal hypoplasia (HP:0000046)	1.79302383
91	Abnormality of fatty-acid metabolism (HP:0004359)	1.78433824
92	Type I diabetes mellitus (HP:0100651)	1.78373801
93	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78314026
94	Dicarboxylic aciduria (HP:0003215)	1.78314026
95	Breast carcinoma (HP:0003002)	1.77785865
96	Abnormality of midbrain morphology (HP:0002418)	1.76747505
97	Molar tooth sign on MRI (HP:0002419)	1.76747505
98	Congenital stationary night blindness (HP:0007642)	1.76397347
99	Late onset (HP:0003584)	1.75926011
100	Progressive inability to walk (HP:0002505)	1.75399835

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	5.70560140
2	FRK	4.86120315
3	MAP4K2	4.74342722
4	EPHA3	3.77702537
5	MAP3K4	3.61419725
6	MAP2K7	3.28052933
7	DYRK3	2.84678956
8	MST4	2.38397178
9	TRIM28	2.31124157
10	WNK3	2.27569652
11	FGFR2	2.14091272
12	MAPKAPK3	2.00648458
13	AKT3	1.77719724
14	PLK2	1.73749741
15	CSNK1G3	1.67157753
16	STK38L	1.67122283
17	ADRBK2	1.57521198
18	CSNK1G1	1.51977700
19	CCNB1	1.44634335
20	PLK3	1.43808404
21	CSNK1A1L	1.39549182
22	CSNK1G2	1.39398706
23	MAPK13	1.34296893
24	MAP2K4	1.33260288
25	PASK	1.32248996
26	EIF2AK3	1.24618323
27	ERBB3	1.23646621
28	BMPR2	1.21825305
29	PHKG2	1.20120944
30	PHKG1	1.20120944
31	DAPK1	1.11089007
32	FER	1.09544025
33	NUAK1	1.07843675
34	MARK1	1.07337754
35	PAK3	1.06645870
36	TAOK3	1.02259868
37	MAP3K6	1.00800280
38	GRK1	0.96492560
39	BMPR1B	0.94899605
40	DAPK2	0.85770504
41	PRKCG	0.84883621
42	PRKCE	0.84823536
43	SGK494	0.84799740
44	SGK223	0.84799740
45	BCKDK	0.76692379
46	VRK2	0.75508497
47	STK4	0.75322955
48	SGK2	0.74276801
49	DYRK2	0.73928898
50	ACVR1B	0.68052475
51	TAOK1	0.67893518
52	TTK	0.65784074
53	SRPK1	0.65091280
54	BCR	0.61722265
55	NTRK3	0.60998464
56	PRKCI	0.59170878
57	PLK4	0.57203891
58	GRK5	0.54148361
59	UHMK1	0.54125065
60	VRK1	0.53464007
61	CASK	0.51037726
62	INSRR	0.49178021
63	PIM1	0.48437934
64	HIPK2	0.48091714
65	LIMK1	0.47563917
66	ADRBK1	0.45352330
67	STK11	0.44957764
68	NLK	0.44581925
69	CLK1	0.43014776
70	TIE1	0.39309518
71	JAK3	0.39177211
72	MAP4K1	0.38551233
73	MAP3K5	0.38476570
74	CSNK1A1	0.36918427
75	WNK4	0.35183780
76	STK24	0.33786489
77	CAMKK2	0.33685800
78	CAMK2A	0.33496928
79	DYRK1A	0.33070010
80	TSSK6	0.32077586
81	PTK2B	0.30845133
82	MKNK1	0.30364711
83	TLK1	0.28810689
84	NTRK2	0.28687241
85	STK39	0.28125802
86	STK16	0.28038960
87	CDK5	0.27972349
88	OXSR1	0.27816516
89	PRKAA1	0.27531069
90	MKNK2	0.27420881
91	CSNK1D	0.26817143
92	MINK1	0.26006859
93	PRKACA	0.24347953
94	PIK3CG	0.24284062
95	SIK3	0.22175421
96	BRD4	0.21824389
97	PINK1	0.19116511
98	PRKAA2	0.18297458
99	FGFR3	0.17788825
100	OBSCN	0.17348898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.21004068
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.30262235
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.99460939
4	Butanoate metabolism_Homo sapiens_hsa00650	3.66113108
5	Protein export_Homo sapiens_hsa03060	2.83894400
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.61548735
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37221630
8	Fatty acid elongation_Homo sapiens_hsa00062	2.27854123
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.14210478
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07292834
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02811713
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.97877984
13	Regulation of autophagy_Homo sapiens_hsa04140	1.88103541
14	Nicotine addiction_Homo sapiens_hsa05033	1.74534163
15	Phototransduction_Homo sapiens_hsa04744	1.63917689
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.50629937
17	Parkinsons disease_Homo sapiens_hsa05012	1.47328252
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43069606
19	Circadian entrainment_Homo sapiens_hsa04713	1.40302458
20	Sulfur metabolism_Homo sapiens_hsa00920	1.36071144
21	Peroxisome_Homo sapiens_hsa04146	1.33561123
22	ABC transporters_Homo sapiens_hsa02010	1.33240698
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.30057814
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.22136651
25	GABAergic synapse_Homo sapiens_hsa04727	1.18590182
26	Alzheimers disease_Homo sapiens_hsa05010	1.17344761
27	Mismatch repair_Homo sapiens_hsa03430	1.15104462
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.13284073
29	Morphine addiction_Homo sapiens_hsa05032	1.12303830
30	Basal transcription factors_Homo sapiens_hsa03022	1.11018138
31	Propanoate metabolism_Homo sapiens_hsa00640	1.10797971
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10361582
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10275329
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.08997887
35	Taste transduction_Homo sapiens_hsa04742	1.08637827
36	Caffeine metabolism_Homo sapiens_hsa00232	1.05644724
37	Insulin secretion_Homo sapiens_hsa04911	1.03697342
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.01130004
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01058994
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01051817
41	RNA degradation_Homo sapiens_hsa03018	1.00823412
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.99673780
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.98771526
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.94863614
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.93326306
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92131588
47	Vibrio cholerae infection_Homo sapiens_hsa05110	0.89266912
48	Serotonergic synapse_Homo sapiens_hsa04726	0.88705050
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87482509
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86289328
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85159609
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83989770
53	Huntingtons disease_Homo sapiens_hsa05016	0.83596127
54	Homologous recombination_Homo sapiens_hsa03440	0.81179934
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81129861
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79731156
57	Base excision repair_Homo sapiens_hsa03410	0.78364191
58	Amphetamine addiction_Homo sapiens_hsa05031	0.74665624
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.73316063
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73064647
61	Purine metabolism_Homo sapiens_hsa00230	0.68800263
62	Metabolic pathways_Homo sapiens_hsa01100	0.68520972
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68133031
64	Retinol metabolism_Homo sapiens_hsa00830	0.65594711
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62601112
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.62588363
67	Olfactory transduction_Homo sapiens_hsa04740	0.62408512
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.62344725
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61956149
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61774690
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61367450
72	Circadian rhythm_Homo sapiens_hsa04710	0.61163530
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.60416523
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58256546
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58160031
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.58050002
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58009262
78	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.57048277
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54096453
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53665763
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53480927
82	Proteasome_Homo sapiens_hsa03050	0.52873653
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46798875
84	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46161221
85	Glutathione metabolism_Homo sapiens_hsa00480	0.45886255
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45205841
87	RNA polymerase_Homo sapiens_hsa03020	0.44268270
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42956541
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40204913
90	Long-term depression_Homo sapiens_hsa04730	0.37739904
91	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36305356
92	Cocaine addiction_Homo sapiens_hsa05030	0.35743687
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35733801
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.34591415
95	Bile secretion_Homo sapiens_hsa04976	0.33905354
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31331868
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25966628
98	RNA transport_Homo sapiens_hsa03013	0.21468143
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.20275621
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.17593993

PRUNEP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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