PRX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myelination in peripheral nervous system (GO:0022011)8.16859878
2peripheral nervous system axon ensheathment (GO:0032292)8.16859878
3hemidesmosome assembly (GO:0031581)6.50207602
4cellular component maintenance (GO:0043954)6.41853361
5peptidyl-tyrosine autophosphorylation (GO:0038083)6.08775056
6basement membrane organization (GO:0071711)5.73928222
7cell adhesion mediated by integrin (GO:0033627)5.69595066
8myelin assembly (GO:0032288)5.48134683
9Leydig cell differentiation (GO:0033327)5.44815483
10cellular response to growth hormone stimulus (GO:0071378)5.20076622
11regulation of pigment cell differentiation (GO:0050932)5.13428122
12cytoskeletal anchoring at plasma membrane (GO:0007016)5.12682411
13positive regulation of developmental pigmentation (GO:0048087)5.01358748
14negative regulation of erythrocyte differentiation (GO:0045647)4.97391617
15peripheral nervous system development (GO:0007422)4.87904273
16myelination (GO:0042552)4.66130074
17male sex determination (GO:0030238)4.62941548
18* ensheathment of neurons (GO:0007272)4.51526332
19* axon ensheathment (GO:0008366)4.51526332
20positive regulation of neurological system process (GO:0031646)4.37230402
21cellular hyperosmotic response (GO:0071474)4.30482618
22positive regulation of Rho protein signal transduction (GO:0035025)4.23896471
23regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.18706293
24renal system development (GO:0072001)3.92935277
25collagen fibril organization (GO:0030199)3.91334768
26myelin maintenance (GO:0043217)3.91055096
27definitive hemopoiesis (GO:0060216)3.90021186
28extracellular fibril organization (GO:0043206)3.89340471
29cell-substrate junction assembly (GO:0007044)3.78251525
30proline transport (GO:0015824)3.75500788
31positive regulation of vasculogenesis (GO:2001214)3.74521362
32calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.72059387
33endocardial cushion development (GO:0003197)3.70580460
34hyperosmotic salinity response (GO:0042538)3.68398608
35endothelium development (GO:0003158)3.65546769
36surfactant homeostasis (GO:0043129)3.61759036
37JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.58508958
38SMAD protein complex assembly (GO:0007183)3.55340495
39pentose-phosphate shunt (GO:0006098)3.49583645
40skin development (GO:0043588)3.48833825
41wound healing, spreading of epidermal cells (GO:0035313)3.47645098
42collagen catabolic process (GO:0030574)3.45267069
43protein heterotrimerization (GO:0070208)3.43855650
44positive thymic T cell selection (GO:0045059)3.43205973
45renal filtration (GO:0097205)3.41348638
46collagen metabolic process (GO:0032963)3.38170918
47neurofilament cytoskeleton organization (GO:0060052)3.37761125
48regulation of vasculogenesis (GO:2001212)3.36961549
49endodermal cell differentiation (GO:0035987)3.36733741
50glomerular filtration (GO:0003094)3.35194066
51cranial nerve structural organization (GO:0021604)3.30913096
52multicellular organismal macromolecule metabolic process (GO:0044259)3.30690500
53extracellular matrix disassembly (GO:0022617)3.30476659
54cell-substrate adherens junction assembly (GO:0007045)3.26990881
55focal adhesion assembly (GO:0048041)3.26990881
56cellular response to nitric oxide (GO:0071732)3.24980035
57positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.24818676
58multicellular organismal catabolic process (GO:0044243)3.24769150
59semaphorin-plexin signaling pathway (GO:0071526)3.20802873
60glial cell proliferation (GO:0014009)3.20241119
61detection of temperature stimulus (GO:0016048)3.20013864
62fibril organization (GO:0097435)3.18514648
63positive regulation of histone deacetylation (GO:0031065)3.13618622
64substrate adhesion-dependent cell spreading (GO:0034446)3.11422246
65epithelial cell-cell adhesion (GO:0090136)3.09829744
66multicellular organismal metabolic process (GO:0044236)3.08116505
67negative regulation of granulocyte differentiation (GO:0030853)3.06629085
68positive regulation of cellular amide metabolic process (GO:0034250)3.06576101
69cell-matrix adhesion (GO:0007160)3.05074181
70peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04573836
71pinocytosis (GO:0006907)3.00493130
72cellular response to reactive nitrogen species (GO:1902170)2.98927738
73positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.98634819
74cell volume homeostasis (GO:0006884)2.96994427
75negative regulation of cell size (GO:0045792)2.95402448
76regulation of myelination (GO:0031641)2.92407596
77regulation of endothelial cell differentiation (GO:0045601)2.92060491
78positive regulation of odontogenesis (GO:0042482)2.90013852
79positive regulation of receptor recycling (GO:0001921)2.88554606
80cell junction organization (GO:0034330)2.87552216
81plasma membrane repair (GO:0001778)2.86328946
82regulation of p38MAPK cascade (GO:1900744)2.86035393
83glucose catabolic process (GO:0006007)2.85100886
84anatomical structure arrangement (GO:0048532)2.82334858
85cell-substrate adhesion (GO:0031589)2.82004797
86alanine transport (GO:0032328)2.81365828
87skeletal muscle contraction (GO:0003009)2.81162372
88blood vessel maturation (GO:0001955)2.81082554
89NADPH regeneration (GO:0006740)2.80952449
90thymic T cell selection (GO:0045061)2.80141613
91cortical actin cytoskeleton organization (GO:0030866)2.78521739
92negative regulation of interleukin-2 production (GO:0032703)2.77708088
93extracellular matrix assembly (GO:0085029)2.77329385
94lymph vessel development (GO:0001945)2.76555951
95embryonic placenta development (GO:0001892)2.76056451
96hippo signaling (GO:0035329)2.74393983
97negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.73284525
98negative regulation of fatty acid transport (GO:2000192)2.73119305
99cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.72955282
100negative regulation of stress fiber assembly (GO:0051497)2.72789386
101cell migration in hindbrain (GO:0021535)2.71023119
102adherens junction assembly (GO:0034333)2.70209087
103anatomical structure maturation (GO:0071695)2.68241416
104establishment of apical/basal cell polarity (GO:0035089)2.66655676
105layer formation in cerebral cortex (GO:0021819)2.65129910
106chemical homeostasis within a tissue (GO:0048875)2.63734683
107cell-cell junction organization (GO:0045216)2.63175318
108hyperosmotic response (GO:0006972)2.62748265
109phosphate ion homeostasis (GO:0055062)2.62470796
110trivalent inorganic anion homeostasis (GO:0072506)2.62470796
111paraxial mesoderm development (GO:0048339)2.62298704
112negative regulation of actin filament bundle assembly (GO:0032232)2.62060000
113response to laminar fluid shear stress (GO:0034616)2.61688921
114negative regulation of catenin import into nucleus (GO:0035414)2.61378011
115growth hormone receptor signaling pathway (GO:0060396)2.61257975
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.60737182
117enteric nervous system development (GO:0048484)2.58919073
118positive regulation of endothelial cell differentiation (GO:0045603)2.58846812
119Rho protein signal transduction (GO:0007266)2.58668421
120extracellular matrix organization (GO:0030198)2.58073454
121positive regulation of protein deacetylation (GO:0090312)2.57378848
122extracellular structure organization (GO:0043062)2.57236455
123gas transport (GO:0015669)2.57204359
124regulation of sodium ion transmembrane transporter activity (GO:2000649)2.57051695
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56956083
126camera-type eye morphogenesis (GO:0048593)2.56209068
127stress fiber assembly (GO:0043149)2.55835775
128protein targeting to plasma membrane (GO:0072661)2.55769590
129lymphangiogenesis (GO:0001946)2.54758064
130branching involved in salivary gland morphogenesis (GO:0060445)2.54587633
131actin filament depolymerization (GO:0030042)2.54266120
132negative regulation of neural precursor cell proliferation (GO:2000178)2.53822209
133hypotonic response (GO:0006971)2.53707109
134integrin-mediated signaling pathway (GO:0007229)2.52365108
135actin-myosin filament sliding (GO:0033275)2.52160800
136muscle filament sliding (GO:0030049)2.52160800
137regulation of hippo signaling (GO:0035330)2.51666133
138vascular endothelial growth factor signaling pathway (GO:0038084)2.51016433
139establishment or maintenance of monopolar cell polarity (GO:0061339)2.50875506
140establishment of monopolar cell polarity (GO:0061162)2.50875506
141blood vessel development (GO:0001568)2.50818279
142atrioventricular valve morphogenesis (GO:0003181)2.50493592
143negative regulation of potassium ion transmembrane transport (GO:1901380)2.49428506
144phagocytosis, recognition (GO:0006910)2.49341193
145positive regulation of p38MAPK cascade (GO:1900745)2.46411757
146polarized epithelial cell differentiation (GO:0030859)2.46260402
147ectodermal placode formation (GO:0060788)2.46236984
148cell junction assembly (GO:0034329)2.45759452
149negative regulation of adherens junction organization (GO:1903392)2.45568561
150negative regulation of cell junction assembly (GO:1901889)2.45568561
151cellular response to thyroid hormone stimulus (GO:0097067)2.45166950
152embryonic process involved in female pregnancy (GO:0060136)2.44151487
153regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.44057102
154regulation of response to osmotic stress (GO:0047484)2.43974180
155hyaluronan catabolic process (GO:0030214)2.43038977
156norepinephrine metabolic process (GO:0042415)2.41539705
157angiogenesis involved in wound healing (GO:0060055)2.41368639
158apoptotic process involved in morphogenesis (GO:0060561)2.40094723
159regulation of cholesterol storage (GO:0010885)2.39486551
160positive regulation of myotube differentiation (GO:0010831)2.37629028
161regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.36677935
162negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.36436787
163low-density lipoprotein particle clearance (GO:0034383)2.36002853
164cardiac muscle cell proliferation (GO:0060038)2.34334322
165positive T cell selection (GO:0043368)2.32634614
166UV protection (GO:0009650)2.32055983
167apoptotic cell clearance (GO:0043277)2.31272421
168cell fate commitment involved in formation of primary germ layer (GO:0060795)2.29345093
169response to fluid shear stress (GO:0034405)2.28221943
170response to growth hormone (GO:0060416)2.27643876
171regulation of fatty acid beta-oxidation (GO:0031998)2.27317523
172endothelial cell chemotaxis (GO:0035767)2.27134234
173regulation of amyloid precursor protein catabolic process (GO:1902991)2.26904611
174endocrine hormone secretion (GO:0060986)2.26760048
175negative regulation of homotypic cell-cell adhesion (GO:0034111)2.24852598
176osteoblast development (GO:0002076)2.24644417
177endothelial cell morphogenesis (GO:0001886)2.23747933
178cell-cell junction maintenance (GO:0045217)13.8790708
179cell junction maintenance (GO:0034331)11.1995566
180neuronal action potential propagation (GO:0019227)10.1323986

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human5.40851754
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.10191890
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.78457345
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.43670763
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.30165211
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.20562315
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96757418
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.66705575
9VDR_21846776_ChIP-Seq_THP-1_Human2.63422448
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.56758144
11MYC_22102868_ChIP-Seq_BL_Human2.52655702
12CLOCK_20551151_ChIP-Seq_293T_Human2.41407804
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36422006
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.31299649
15* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29638826
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27999784
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23353807
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08801307
19GATA1_22025678_ChIP-Seq_K562_Human2.03832745
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.02620677
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01193750
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.99398476
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97339133
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90312007
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89687734
26SCL_19346495_ChIP-Seq_HPC-7_Human1.84310631
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77745298
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77350785
29KDM2B_26808549_Chip-Seq_K562_Human1.75164676
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73787071
31* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73260281
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.72713956
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70092103
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69705534
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69381802
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.67629746
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67466863
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65361826
39AHR_22903824_ChIP-Seq_MCF-7_Human1.60571323
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.58423988
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57033385
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54480942
43* KDM2B_26808549_Chip-Seq_DND41_Human1.53089505
44VDR_24763502_ChIP-Seq_THP-1_Human1.51504108
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51372082
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51003758
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.50652250
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50261712
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.46959157
50GATA1_19941826_ChIP-Seq_K562_Human1.46406337
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46271288
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45440042
53P68_20966046_ChIP-Seq_HELA_Human1.44991703
54MAF_26560356_Chip-Seq_TH1_Human1.42964158
55NCOR1_26117541_ChIP-Seq_K562_Human1.42769203
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.42072295
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40714030
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39691717
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37888829
60* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37767513
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37586703
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.36777398
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36402222
64CREB1_26743006_Chip-Seq_LNCaP_Human1.34601937
65UTX_26944678_Chip-Seq_JUKART_Human1.33326884
66TP53_16413492_ChIP-PET_HCT116_Human1.32739730
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32712796
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.32151270
69RACK7_27058665_Chip-Seq_MCF-7_Human1.31131451
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29871061
71* SMC4_20622854_ChIP-Seq_HELA_Human1.28479965
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28329675
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28273527
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.27997007
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27595243
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.27381915
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.27331118
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26427671
79* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26257461
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25980611
81MAF_26560356_Chip-Seq_TH2_Human1.24923823
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24763932
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23382590
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23177899
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23177899
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22729171
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22046419
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21913352
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21148037
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20449621
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20192391
92CTCF_27219007_Chip-Seq_Bcells_Human1.18992507
93CJUN_26792858_Chip-Seq_BT549_Human1.16359601
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15880892
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15880892
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15880892
97* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14912855
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14376188
99* ELF1_20517297_ChIP-Seq_JURKAT_Human1.13290293
100LXR_22292898_ChIP-Seq_THP-1_Human1.13223871
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.11675359
102SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10812074
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09907548
104IRF8_22096565_ChIP-ChIP_GC-B_Human1.09132361
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07904321
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07305669
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06541149
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06137451
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05860711
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05860711
111SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05665898
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.04860460
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.04691033
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04651919
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04394094
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04059515
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03989886
118* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03766513
119* TP53_22127205_ChIP-Seq_IMR90_Human1.03192041
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02750704
121TBX20_22080862_ChIP-Seq_HEART_Mouse1.02440293
122TBX20_22328084_ChIP-Seq_HEART_Mouse1.02440293
123ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02078155
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01490372
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01261920
126TP63_22573176_ChIP-Seq_HFKS_Human1.01131682
127* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00837198
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00211796
129PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00177391
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99259420
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99196812
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99063182
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98710481
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98474923
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97600318
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97407674
137JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97133592
138* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96983367
139DROSHA_22980978_ChIP-Seq_HELA_Human0.96682420
140* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96592968
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96394879
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95864096
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95711110
144CTCF_21964334_Chip-Seq_Bcells_Human0.95438696
145* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94679842
146NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94606659
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94290178
148SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94047051
149TCF7_22412390_ChIP-Seq_EML_Mouse0.93740410
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93226737
151JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92369845
152UBF1/2_26484160_Chip-Seq_HMECs_Human0.91748232
153ATF3_27146783_Chip-Seq_COLON_Human0.91002811
154SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90984847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane7.28331930
2MP0008438_abnormal_cutaneous_collagen5.40947514
3MP0003136_yellow_coat_color4.77801672
4MP0008260_abnormal_autophagy3.99730990
5MP0003045_fibrosis3.88350063
6* MP0000920_abnormal_myelination3.56506365
7MP0005275_abnormal_skin_tensile3.55773489
8MP0005623_abnormal_meninges_morphology3.48541543
9MP0000751_myopathy3.43735021
10MP0004858_abnormal_nervous_system3.34438396
11MP0000747_muscle_weakness3.02260130
12MP0009278_abnormal_bone_marrow3.01911071
13MP0000749_muscle_degeneration2.97922299
14MP0005451_abnormal_body_composition2.59702420
15* MP0003634_abnormal_glial_cell2.47434464
16MP0001958_emphysema2.42007449
17MP0001661_extended_life_span2.41350682
18MP0003315_abnormal_perineum_morphology2.33006295
19MP0005058_abnormal_lysosome_morphology2.27474259
20MP0005503_abnormal_tendon_morphology2.14388307
21MP0005397_hematopoietic_system_phenotyp1.96515900
22MP0001545_abnormal_hematopoietic_system1.96515900
23MP0000750_abnormal_muscle_regeneration1.93643803
24MP0004145_abnormal_muscle_electrophysio1.91582685
25MP0000013_abnormal_adipose_tissue1.88223315
26MP0003705_abnormal_hypodermis_morpholog1.83157125
27MP0003950_abnormal_plasma_membrane1.77437682
28MP0003632_abnormal_nervous_system1.75605845
29MP0004130_abnormal_muscle_cell1.72819896
30MP0004381_abnormal_hair_follicle1.72038902
31MP0005076_abnormal_cell_differentiation1.67680783
32MP0004185_abnormal_adipocyte_glucose1.66740302
33MP0006138_congestive_heart_failure1.63225796
34MP0002168_other_aberrant_phenotype1.62732679
35MP0002736_abnormal_nociception_after1.62578311
36MP0008995_early_reproductive_senescence1.61961873
37MP0002938_white_spotting1.57000263
38MP0009840_abnormal_foam_cell1.47150200
39MP0001851_eye_inflammation1.44892700
40MP0004036_abnormal_muscle_relaxation1.44643579
41MP0005375_adipose_tissue_phenotype1.42625444
42MP0003566_abnormal_cell_adhesion1.41053528
43MP0008004_abnormal_stomach_pH1.39556935
44MP0002108_abnormal_muscle_morphology1.39306433
45MP0003631_nervous_system_phenotype1.38046847
46MP0002998_abnormal_bone_remodeling1.35685305
47MP0005595_abnormal_vascular_smooth1.31852938
48MP0003279_aneurysm1.31760805
49MP0005171_absent_coat_pigmentation1.29230309
50MP0002089_abnormal_postnatal_growth/wei1.26857446
51MP0002735_abnormal_chemical_nociception1.25049323
52* MP0001968_abnormal_touch/_nociception1.22285339
53MP0002877_abnormal_melanocyte_morpholog1.21685696
54MP0001542_abnormal_bone_strength1.20835855
55MP0004270_analgesia1.20789910
56MP0002269_muscular_atrophy1.20457805
57MP0010630_abnormal_cardiac_muscle1.17638525
58MP0005666_abnormal_adipose_tissue1.17221431
59MP0001879_abnormal_lymphatic_vessel1.16117726
60MP0005670_abnormal_white_adipose1.14331774
61MP0003329_amyloid_beta_deposits1.11621349
62MP0000465_gastrointestinal_hemorrhage1.11049866
63MP0004947_skin_inflammation1.10113367
64MP0003633_abnormal_nervous_system1.10090237
65MP0010030_abnormal_orbit_morphology1.09016608
66* MP0002272_abnormal_nervous_system1.08332023
67MP0002933_joint_inflammation1.07827545
68MP0010352_gastrointestinal_tract_polyps1.07603559
69MP0003878_abnormal_ear_physiology1.05038940
70MP0005377_hearing/vestibular/ear_phenot1.05038940
71MP0009780_abnormal_chondrocyte_physiolo1.03819697
72MP0000534_abnormal_ureter_morphology1.02980317
73MP0008569_lethality_at_weaning1.02721611
74MP0001986_abnormal_taste_sensitivity1.02677584
75MP0002166_altered_tumor_susceptibility1.00204954
76MP0004808_abnormal_hematopoietic_stem0.99718947
77MP0010234_abnormal_vibrissa_follicle0.98514154
78* MP0002067_abnormal_sensory_capabilities0.97899305
79MP0002332_abnormal_exercise_endurance0.97453538
80MP0005075_abnormal_melanosome_morpholog0.97254517
81MP0003091_abnormal_cell_migration0.97057325
82MP0009333_abnormal_splenocyte_physiolog0.95160652
83MP0002138_abnormal_hepatobiliary_system0.94622533
84MP0009384_cardiac_valve_regurgitation0.93943974
85MP0000249_abnormal_blood_vessel0.93338815
86MP0003828_pulmonary_edema0.93294230
87MP0001849_ear_inflammation0.92678887
88MP0000462_abnormal_digestive_system0.91910988
89MP0003436_decreased_susceptibility_to0.91439485
90MP0001348_abnormal_lacrimal_gland0.90299361
91MP0003453_abnormal_keratinocyte_physiol0.90236356
92MP0001544_abnormal_cardiovascular_syste0.90058509
93MP0005385_cardiovascular_system_phenoty0.90058509
94* MP0002733_abnormal_thermal_nociception0.89240851
95MP0005408_hypopigmentation0.88614118
96MP0004087_abnormal_muscle_fiber0.88130811
97MP0000733_abnormal_muscle_development0.88092308
98MP0002060_abnormal_skin_morphology0.86685926
99MP0001175_abnormal_lung_morphology0.86583101
100MP0004233_abnormal_muscle_weight0.83478372
101MP0003011_delayed_dark_adaptation0.81189891
102MP0005167_abnormal_blood-brain_barrier0.80907148
103MP0001299_abnormal_eye_distance/0.80441863
104MP0002751_abnormal_autonomic_nervous0.79706945
105MP0002106_abnormal_muscle_physiology0.79633724
106MP0002254_reproductive_system_inflammat0.78937945
107MP0003656_abnormal_erythrocyte_physiolo0.78886016
108MP0003567_abnormal_fetal_cardiomyocyte0.78148609
109MP0001243_abnormal_dermal_layer0.76905826
110MP0005508_abnormal_skeleton_morphology0.75344820
111MP0004782_abnormal_surfactant_physiolog0.75209049
112MP0003283_abnormal_digestive_organ0.74518076
113MP0005390_skeleton_phenotype0.73559932
114MP0003303_peritoneal_inflammation0.72677929
115MP0001915_intracranial_hemorrhage0.71314811
116MP0005083_abnormal_biliary_tract0.71231772
117MP0000681_abnormal_thyroid_gland0.70529557
118MP0005464_abnormal_platelet_physiology0.69084429
119MP0005620_abnormal_muscle_contractility0.68928717
120MP0009643_abnormal_urine_homeostasis0.68877431
121MP0002796_impaired_skin_barrier0.68827096
122MP0001533_abnormal_skeleton_physiology0.68825251
123MP0000604_amyloidosis0.68326328
124MP0000767_abnormal_smooth_muscle0.67130977
125MP0005369_muscle_phenotype0.66911491
126MP0004811_abnormal_neuron_physiology0.66621021
127MP0010368_abnormal_lymphatic_system0.64412044
128MP0001270_distended_abdomen0.61755255
129MP0004084_abnormal_cardiac_muscle0.61138299
130MP0005330_cardiomyopathy0.60993102
131MP0002925_abnormal_cardiovascular_devel0.60191972
132MP0005023_abnormal_wound_healing0.58480821
133MP0003385_abnormal_body_wall0.58124470
134MP0008770_decreased_survivor_rate0.57910489
135MP0003300_gastrointestinal_ulcer0.56509309
136MP0000003_abnormal_adipose_tissue0.55213762
137* MP0002734_abnormal_mechanical_nocicepti0.55003019
138MP0002697_abnormal_eye_size0.54022611
139MP0001614_abnormal_blood_vessel0.53272116
140MP0005248_abnormal_Harderian_gland0.53084777
141MP0002229_neurodegeneration0.52489233
142MP0008932_abnormal_embryonic_tissue0.51900739
143MP0000759_abnormal_skeletal_muscle0.51730746
144MP0002133_abnormal_respiratory_system0.51618420
145MP0005388_respiratory_system_phenotype0.51618420
146MP0004883_abnormal_blood_vessel0.50350579
147* MP0010771_integument_phenotype0.50170055
148MP0009046_muscle_twitch0.48367439
149MP0003191_abnormal_cellular_cholesterol0.47645164
150MP0002128_abnormal_blood_circulation0.47372303
151MP0000778_abnormal_nervous_system0.47316334

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)9.93037880
2* Impaired proprioception (HP:0010831)8.53933329
3Upper limb muscle weakness (HP:0003484)7.32699420
4Peripheral hypomyelination (HP:0007182)7.19527031
5* Increased CSF protein (HP:0002922)5.96556122
6Postural tremor (HP:0002174)5.94568230
7Interstitial pulmonary disease (HP:0006530)5.69189774
8Abnormal pupillary function (HP:0007686)5.55394031
9* Onion bulb formation (HP:0003383)5.11569093
10* Steppage gait (HP:0003376)4.95543765
11* Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.74246424
12Progressive sensorineural hearing impairment (HP:0000408)4.57013502
13* Hammertoe (HP:0001765)4.50424331
14* Foot dorsiflexor weakness (HP:0009027)4.23345825
15Round ear (HP:0100830)4.11360701
16* Peripheral demyelination (HP:0011096)4.02882023
17* Abnormality of the foot musculature (HP:0001436)3.89801471
18* Decreased motor nerve conduction velocity (HP:0003431)3.87266857
19Type 1 muscle fiber predominance (HP:0003803)3.72713501
20Atrophic scars (HP:0001075)3.58066077
21Exercise-induced myalgia (HP:0003738)3.31573509
22Progressive hearing impairment (HP:0001730)3.30743974
23Abnormality of the fingertips (HP:0001211)3.14610919
24Aortic aneurysm (HP:0004942)3.06232826
25Muscle fiber inclusion bodies (HP:0100299)3.00987267
26Distal lower limb muscle weakness (HP:0009053)3.00889121
27J-shaped sella turcica (HP:0002680)2.99814323
28Obstructive sleep apnea (HP:0002870)2.91937706
29Nemaline bodies (HP:0003798)2.91895017
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.91454666
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.84163555
32Ulnar deviation of the wrist (HP:0003049)2.82169062
33Distal arthrogryposis (HP:0005684)2.79224761
34Myopathic facies (HP:0002058)2.74443711
35Fragile skin (HP:0001030)2.72867248
36Sex reversal (HP:0012245)2.72659030
37Abnormal sex determination (HP:0012244)2.72659030
38* Abnormality of the vocal cords (HP:0008777)2.71654019
39Cerebral aneurysm (HP:0004944)2.69797594
40Premature rupture of membranes (HP:0001788)2.61519753
41Amelogenesis imperfecta (HP:0000705)2.59930666
42Hypomagnesemia (HP:0002917)2.59660293
43Distal lower limb amyotrophy (HP:0008944)2.58577158
44Muscle fiber splitting (HP:0003555)2.56410881
45Broad face (HP:0000283)2.54097635
46Protrusio acetabuli (HP:0003179)2.45484617
47Bladder diverticulum (HP:0000015)2.38183494
48Vascular tortuosity (HP:0004948)2.38029262
49* Distal sensory impairment (HP:0002936)2.36173035
50Abnormality of calcium-phosphate metabolism (HP:0100530)2.29707551
51Cervical subluxation (HP:0003308)2.28651905
52Ankle contracture (HP:0006466)2.27565429
53Abnormality of magnesium homeostasis (HP:0004921)2.18775683
54Ulnar bowing (HP:0003031)2.12380668
55Mitral regurgitation (HP:0001653)2.10318390
56Arterial tortuosity (HP:0005116)2.10213392
57Progressive muscle weakness (HP:0003323)2.07085895
58Prostate neoplasm (HP:0100787)2.05449656
59Cellulitis (HP:0100658)2.05151630
60Deformed sella turcica (HP:0002681)2.02140144
61Aortic dissection (HP:0002647)2.01138857
62Thin bony cortex (HP:0002753)2.00467366
63* Ulnar claw (HP:0001178)13.8988049
64Termporal pattern (HP:0011008)12.7567756
65Insidious onset (HP:0003587)12.7567756
66* Segmental peripheral demyelination/remyelination (HP:0003481)11.1140325
67Joint stiffness (HP:0001387)1.99278303
68Hypoplasia of the uterus (HP:0000013)1.98971013
69Neck muscle weakness (HP:0000467)1.98851291
70Hemorrhage of the eye (HP:0011885)1.93037177
71* Kyphoscoliosis (HP:0002751)1.92131424
72Alopecia of scalp (HP:0002293)1.91770976
73Disproportionate tall stature (HP:0001519)1.91367994
74Areflexia of lower limbs (HP:0002522)1.89959205
75Mitral valve prolapse (HP:0001634)1.88993796
76Renovascular hypertension (HP:0100817)1.88142610
77Turricephaly (HP:0000262)1.85885854
78Lower limb amyotrophy (HP:0007210)1.85133561
79Abnormal auditory evoked potentials (HP:0006958)1.84383522
80Soft skin (HP:0000977)1.83835451
81Diaphragmatic weakness (HP:0009113)1.83156198
82Prolonged bleeding time (HP:0003010)1.81809930
83Aneurysm (HP:0002617)1.81122939
84Stridor (HP:0010307)1.80482153
85Patellar dislocation (HP:0002999)1.79791673
86Germ cell neoplasia (HP:0100728)1.79485175
87Systemic lupus erythematosus (HP:0002725)1.77841228
88Dysmetric saccades (HP:0000641)1.76870362
89Metaphyseal cupping (HP:0003021)1.75913167
90Premature skin wrinkling (HP:0100678)1.74623440
91Easy fatigability (HP:0003388)1.74109990
92Polygenic inheritance (HP:0010982)1.73616967
93Slender build (HP:0001533)1.73052490
94Flat cornea (HP:0007720)1.72822172
95Joint contractures involving the joints of the feet (HP:0100492)1.72767357
96Flexion contracture of toe (HP:0005830)1.72767357
97Muscle stiffness (HP:0003552)1.72671668
98Abnormality of the radial head (HP:0003995)1.71258328
99Increased IgE level (HP:0003212)1.67547355
100Abnormal hemoglobin (HP:0011902)1.66707334
101Mesangial abnormality (HP:0001966)1.66412034
102Abnormality of the calcaneus (HP:0008364)1.65256920
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.65175449
104Osteolytic defects of the hand bones (HP:0009699)1.65175449
105Atrioventricular block (HP:0001678)1.64911193
106Bronchomalacia (HP:0002780)1.64775757
107Spinal cord lesions (HP:0100561)1.63087484
108Syringomyelia (HP:0003396)1.63087484
109Achilles tendon contracture (HP:0001771)1.62580338
110Myoglobinuria (HP:0002913)1.62105760
111Calcaneovalgus deformity (HP:0001848)1.61735738
112Vertebral compression fractures (HP:0002953)1.60030352
113Dislocated radial head (HP:0003083)1.59662547
114Bulbar palsy (HP:0001283)1.58941389
115Abnormality of the pupil (HP:0000615)1.58697759
116Generalized amyotrophy (HP:0003700)1.57397138
117Joint laxity (HP:0001388)1.57249242
118Myotonia (HP:0002486)1.56516091
119Bowel diverticulosis (HP:0005222)1.54834050
120Dilatation of the ascending aorta (HP:0005111)1.53696001
121Peritonitis (HP:0002586)1.52080994
122Hypercalciuria (HP:0002150)1.49978139
123Hematochezia (HP:0002573)1.49504146
124Esophageal atresia (HP:0002032)1.47019604
125Genu recurvatum (HP:0002816)1.42618542
126Wrist flexion contracture (HP:0001239)1.41689050
127Striae distensae (HP:0001065)1.40905342
128Gait ataxia (HP:0002066)1.37022348
129Aplasia cutis congenita (HP:0001057)1.35445040
130Milia (HP:0001056)1.31773603
131Increased connective tissue (HP:0009025)1.28185700
132Abnormality of the lower motor neuron (HP:0002366)1.27537764
133Overgrowth (HP:0001548)1.23644645
134Aplasia/hypoplasia of the uterus (HP:0008684)1.23429296
135* Slow progression (HP:0003677)1.23053024
136Childhood onset (HP:0011463)1.22571502
137Broad metatarsal (HP:0001783)1.21513496
138Hyperextensible skin (HP:0000974)1.21257106
139* Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.21171642
140Gonadal dysgenesis (HP:0000133)1.20865708
141Shallow orbits (HP:0000586)1.19682853
142Venous insufficiency (HP:0005293)1.18013645
143Spinal rigidity (HP:0003306)1.17362775
144Hypoventilation (HP:0002791)1.15652172
145Neonatal short-limb short stature (HP:0008921)1.14311592
146Muscular dystrophy (HP:0003560)1.12392024
147Increased variability in muscle fiber diameter (HP:0003557)1.12254218
148Renal duplication (HP:0000075)1.11627432
149Trismus (HP:0000211)1.11267328
150Gastrointestinal atresia (HP:0002589)1.08839614
151Hyporeflexia of lower limbs (HP:0002600)1.08508271
152Venous abnormality (HP:0002624)1.07672924
153Blue sclerae (HP:0000592)1.06426235
154Wormian bones (HP:0002645)1.06365569
155Difficulty running (HP:0009046)1.05003546
156Hyperacusis (HP:0010780)1.04772412
157Camptodactyly of toe (HP:0001836)1.04550119
158Mildly elevated creatine phosphokinase (HP:0008180)1.03109160
159Gastrointestinal infarctions (HP:0005244)1.01253834
160Polycythemia (HP:0001901)1.01169872
161Pterygium (HP:0001059)1.00848791
162* Pes cavus (HP:0001761)1.00141742
163Keratoconus (HP:0000563)1.00034680
164Increased corneal curvature (HP:0100692)1.00034680
165Juvenile onset (HP:0003621)0.99129248
166Annular pancreas (HP:0001734)0.98290649
167Difficulty climbing stairs (HP:0003551)0.97420540
168Abnormality of skeletal muscle fiber size (HP:0012084)0.96419860
169Long toe (HP:0010511)0.95161835
170Insomnia (HP:0100785)0.94085794
171Split hand (HP:0001171)0.92649894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK24.20791591
2PRPF4B3.45990365
3SMG13.44011749
4IRAK13.12385021
5KSR22.96924895
6EPHB12.95966703
7TRIB32.90810677
8RET2.90409218
9MAP3K22.50406450
10CDK82.47629651
11MAP2K32.31976805
12TIE12.30193156
13ICK2.30138531
14LMTK22.24899382
15PRKD32.11677969
16NTRK12.10099923
17LIMK12.06558468
18STK392.04240378
19MARK22.03182553
20UHMK11.99848478
21LRRK21.98219789
22PKN21.81648401
23LATS21.77818099
24WNK41.77050774
25PAK41.72415909
26PTK61.71712303
27PDGFRA1.71689851
28TTN1.67871791
29EPHB21.66655579
30TAOK21.57707993
31TGFBR21.51070991
32KDR1.49807109
33OBSCN1.46418779
34MAP4K11.44459577
35CDK91.43572898
36ERBB21.40565451
37MAP3K71.39820314
38WNK11.39151375
39FER1.38642656
40BMPR1B1.37458942
41DDR21.36212003
42PAK61.35242859
43MAPK121.33014851
44PTK21.31956922
45RPS6KL11.30989927
46RPS6KC11.30989927
47STK101.29390652
48MAP3K31.27775016
49MAP3K131.22601322
50ZAP701.21383319
51MATK1.20395648
52VRK21.18571638
53MET1.18562792
54LATS11.12427804
55FES1.09355243
56SCYL21.09351209
57PTK2B1.08887500
58RPS6KA61.08415080
59BMX1.06156649
60CAMK1D1.03906076
61KIT1.01468811
62PHKG10.99231172
63PHKG20.99231172
64RIPK10.99029763
65TYRO30.97340352
66MAP3K90.95913916
67STK380.93841147
68MAP2K10.92674154
69ILK0.91952675
70DYRK1B0.88721175
71ROCK10.87938860
72MAPK70.87551910
73CDK60.86802426
74BLK0.85887142
75PDGFRB0.84454142
76EEF2K0.84152892
77CSK0.83321939
78PRKD20.83279994
79TBK10.83176273
80GSK3A0.82490288
81CLK10.82115729
82MAP2K20.80786363
83ROCK20.78471188
84SIK10.77166797
85FGFR20.76507868
86PRKD10.76374078
87MAP3K80.74128236
88CAMK1G0.73835314
89MINK10.73696178
90CDK70.71932388
91DAPK20.71823983
92NME20.71818661
93MAP3K10.69733866
94RPS6KA20.69479682
95DAPK30.67703740
96FLT30.67037121
97MAP3K110.67013940
98MTOR0.65898568
99MAPK110.65829788
100NTRK30.65638522
101MAP3K60.63689138
102FGFR30.62283896
103TESK20.61157239
104SRC0.60827638
105PAK20.60163680
106CDK50.59787387
107MARK30.58819062
108TGFBR10.58051130
109FYN0.57597033
110TRPM70.55895446
111TAOK10.55699617
112PRKG20.55541068
113MAP3K140.53964988
114GRK50.53429952
115RPS6KA40.53279053
116RPS6KB20.52823202
117MAP3K40.52229786
118GRK60.51338739
119RIPK40.51183462
120MAPK40.51131092
121CDK120.49381514
122MAP3K100.46295748
123MAPKAPK20.46070006
124NEK10.45920168
125MELK0.45200447
126FGFR40.45079264
127BRD40.44669141
128ALK0.42672794
129CDC42BPA0.41264445
130PAK30.40867239
131ADRBK10.40463846
132PRKCH0.40138908
133MAPK30.39896517
134INSR0.39254072
135RPS6KA10.37679287
136SGK30.36755128
137ERN10.35909696
138MOS0.35596155
139HIPK20.34667560
140CDK140.34299705
141JAK20.34289114
142PDK10.34150159
143NEK90.34097817
144IRAK30.33620073
145PIK3CG0.33286174
146PDPK10.30278459
147PAK10.28490625
148FRK0.25834718
149EGFR0.25712203
150MAPKAPK30.24573281
151EPHA20.24425471
152EPHA30.23637323

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.14560727
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65948895
3Focal adhesion_Homo sapiens_hsa045102.53540526
4Viral myocarditis_Homo sapiens_hsa054162.52838075
5Small cell lung cancer_Homo sapiens_hsa052222.44555270
6Other glycan degradation_Homo sapiens_hsa005112.40744367
7Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.36258712
8Dorso-ventral axis formation_Homo sapiens_hsa043202.29998127
9Amoebiasis_Homo sapiens_hsa051462.26551409
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.15939601
11Protein digestion and absorption_Homo sapiens_hsa049742.12675853
12Dilated cardiomyopathy_Homo sapiens_hsa054142.09792526
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.09527147
14Axon guidance_Homo sapiens_hsa043602.02080939
15Tight junction_Homo sapiens_hsa045302.01264920
16Notch signaling pathway_Homo sapiens_hsa043301.87188009
17Pentose phosphate pathway_Homo sapiens_hsa000301.75128956
18Thyroid cancer_Homo sapiens_hsa052161.74904395
19Glioma_Homo sapiens_hsa052141.70380500
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68470676
21Toxoplasmosis_Homo sapiens_hsa051451.63698652
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.60987460
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57756864
24Adherens junction_Homo sapiens_hsa045201.46561459
25Chronic myeloid leukemia_Homo sapiens_hsa052201.46200338
26Endometrial cancer_Homo sapiens_hsa052131.46107107
27Proteoglycans in cancer_Homo sapiens_hsa052051.43012884
28Hedgehog signaling pathway_Homo sapiens_hsa043401.42974859
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40267202
30Bladder cancer_Homo sapiens_hsa052191.34963923
31Estrogen signaling pathway_Homo sapiens_hsa049151.29705687
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.28891284
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27298567
34VEGF signaling pathway_Homo sapiens_hsa043701.23383867
35Platelet activation_Homo sapiens_hsa046111.23157746
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20135067
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17729344
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17020598
39Leishmaniasis_Homo sapiens_hsa051401.16834762
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16778198
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14167578
42B cell receptor signaling pathway_Homo sapiens_hsa046621.14152752
43Hematopoietic cell lineage_Homo sapiens_hsa046401.13773487
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.10979320
45Gap junction_Homo sapiens_hsa045401.10639612
46ErbB signaling pathway_Homo sapiens_hsa040121.08189301
47MicroRNAs in cancer_Homo sapiens_hsa052061.07341261
48Malaria_Homo sapiens_hsa051441.04397842
49Insulin resistance_Homo sapiens_hsa049311.04393863
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.04389659
51Prion diseases_Homo sapiens_hsa050201.04127243
52Melanoma_Homo sapiens_hsa052181.01870915
53Staphylococcus aureus infection_Homo sapiens_hsa051501.01657790
54Rap1 signaling pathway_Homo sapiens_hsa040151.01237691
55Hippo signaling pathway_Homo sapiens_hsa043901.00270804
56Graft-versus-host disease_Homo sapiens_hsa053320.99243592
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.95814434
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.95577827
59Allograft rejection_Homo sapiens_hsa053300.95516926
60GnRH signaling pathway_Homo sapiens_hsa049120.94113319
61Asthma_Homo sapiens_hsa053100.93328273
62Pathways in cancer_Homo sapiens_hsa052000.93147374
63Renal cell carcinoma_Homo sapiens_hsa052110.90368431
64Autoimmune thyroid disease_Homo sapiens_hsa053200.87200609
65Non-small cell lung cancer_Homo sapiens_hsa052230.86711702
66Pertussis_Homo sapiens_hsa051330.86562867
67Pancreatic cancer_Homo sapiens_hsa052120.86278611
68Long-term depression_Homo sapiens_hsa047300.86070913
69Ovarian steroidogenesis_Homo sapiens_hsa049130.83361117
70Influenza A_Homo sapiens_hsa051640.82627484
71HTLV-I infection_Homo sapiens_hsa051660.82211145
72mTOR signaling pathway_Homo sapiens_hsa041500.82204577
73Type II diabetes mellitus_Homo sapiens_hsa049300.81672800
74AMPK signaling pathway_Homo sapiens_hsa041520.80856831
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.80793237
76Lysosome_Homo sapiens_hsa041420.80446971
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.79518179
78African trypanosomiasis_Homo sapiens_hsa051430.79137155
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79081901
80Gastric acid secretion_Homo sapiens_hsa049710.79011374
81ABC transporters_Homo sapiens_hsa020100.78335892
82Prolactin signaling pathway_Homo sapiens_hsa049170.76938148
83Insulin signaling pathway_Homo sapiens_hsa049100.76283156
84Long-term potentiation_Homo sapiens_hsa047200.76166692
85Osteoclast differentiation_Homo sapiens_hsa043800.74796046
86Colorectal cancer_Homo sapiens_hsa052100.74298985
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71411727
88TNF signaling pathway_Homo sapiens_hsa046680.70296652
89Ras signaling pathway_Homo sapiens_hsa040140.70291671
90Steroid biosynthesis_Homo sapiens_hsa001000.70281261
91Renin secretion_Homo sapiens_hsa049240.69880619
92Apoptosis_Homo sapiens_hsa042100.69848969
93Renin-angiotensin system_Homo sapiens_hsa046140.69654611
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69450398
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69189439
96Hepatitis C_Homo sapiens_hsa051600.68773792
97Endocytosis_Homo sapiens_hsa041440.68568441
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.66455104
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66283037
100Lysine degradation_Homo sapiens_hsa003100.65746780
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65290586
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64742483
103Choline metabolism in cancer_Homo sapiens_hsa052310.64122307
104Alcoholism_Homo sapiens_hsa050340.63745012
105Melanogenesis_Homo sapiens_hsa049160.63302139
106Salmonella infection_Homo sapiens_hsa051320.62524072
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62156834
108Cholinergic synapse_Homo sapiens_hsa047250.61732444
109Bile secretion_Homo sapiens_hsa049760.61341701
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60808636
111Shigellosis_Homo sapiens_hsa051310.59612695
112Antigen processing and presentation_Homo sapiens_hsa046120.59162000
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58636979
114HIF-1 signaling pathway_Homo sapiens_hsa040660.56857280
115Hepatitis B_Homo sapiens_hsa051610.55903339
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54828378
117Inositol phosphate metabolism_Homo sapiens_hsa005620.54482325
118Glucagon signaling pathway_Homo sapiens_hsa049220.53616023
119Thyroid hormone synthesis_Homo sapiens_hsa049180.53560934
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.53367949
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52458347
122Prostate cancer_Homo sapiens_hsa052150.52421029
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52129230
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51223692
125Taste transduction_Homo sapiens_hsa047420.50051868
126Oocyte meiosis_Homo sapiens_hsa041140.49725440
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48992833
128TGF-beta signaling pathway_Homo sapiens_hsa043500.48049147
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47091112
130Salivary secretion_Homo sapiens_hsa049700.46186512
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45234225
132Viral carcinogenesis_Homo sapiens_hsa052030.44194834
133Acute myeloid leukemia_Homo sapiens_hsa052210.43128720
134Oxytocin signaling pathway_Homo sapiens_hsa049210.42626653
135Systemic lupus erythematosus_Homo sapiens_hsa053220.42328402
136MAPK signaling pathway_Homo sapiens_hsa040100.39934690
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39056813
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39035657
139Dopaminergic synapse_Homo sapiens_hsa047280.38429940

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