PSAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.33696693
2modulation by symbiont of host defense response (GO:0052031)5.33696693
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.33696693
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.33696693
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.33696693
6modulation by symbiont of host immune response (GO:0052553)5.33696693
7response to peptidoglycan (GO:0032494)4.85084866
8negative regulation of interleukin-12 production (GO:0032695)4.73754996
9glycosphingolipid catabolic process (GO:0046479)4.67711050
10regulation of interferon-beta biosynthetic process (GO:0045357)4.66313615
11oligosaccharide catabolic process (GO:0009313)4.27471120
12macrophage activation involved in immune response (GO:0002281)4.23977207
13glycolipid catabolic process (GO:0019377)4.19211676
14positive regulation of gamma-delta T cell activation (GO:0046645)4.06872847
15detection of other organism (GO:0098543)3.96700377
16amino sugar catabolic process (GO:0046348)3.90672709
17detection of molecule of bacterial origin (GO:0032490)3.89358576
18positive regulation of cellular amide metabolic process (GO:0034250)3.75782400
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71577180
20ceramide catabolic process (GO:0046514)3.67694145
21apoptotic cell clearance (GO:0043277)3.61387730
22detection of external biotic stimulus (GO:0098581)3.58334998
23detection of bacterium (GO:0016045)3.55405606
24mannose metabolic process (GO:0006013)3.54209636
25sodium ion export (GO:0071436)3.53632300
26regulation of mast cell degranulation (GO:0043304)3.51470368
27lipopolysaccharide-mediated signaling pathway (GO:0031663)3.47830729
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40801281
29response to host immune response (GO:0052572)3.40801281
30synaptic vesicle maturation (GO:0016188)3.32493972
31response to thyroid hormone (GO:0097066)3.31589676
32negative regulation of erythrocyte differentiation (GO:0045647)3.31219262
33positive regulation of macrophage cytokine production (GO:0060907)3.30110181
34T-helper 1 type immune response (GO:0042088)3.29485817
35positive regulation of mast cell degranulation (GO:0043306)3.29130924
36positive regulation of mast cell activation involved in immune response (GO:0033008)3.29130924
37regulation of mononuclear cell migration (GO:0071675)3.25006932
38positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24208611
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23795422
40regulation of mast cell activation involved in immune response (GO:0033006)3.20159745
41detection of biotic stimulus (GO:0009595)3.19843035
42response to host (GO:0075136)3.18507938
43response to host defenses (GO:0052200)3.18507938
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18507938
45regulation of cholesterol storage (GO:0010885)3.17249231
46N-acetylneuraminate metabolic process (GO:0006054)3.16328109
47cellular extravasation (GO:0045123)3.14503685
48response to muramyl dipeptide (GO:0032495)3.13903294
49positive regulation of monocyte chemotaxis (GO:0090026)3.11212611
50regulation of ARF protein signal transduction (GO:0032012)3.10041798
51granulocyte activation (GO:0036230)3.08466829
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07906440
53protein localization to endosome (GO:0036010)3.07851428
54low-density lipoprotein particle clearance (GO:0034383)3.07808064
55microglial cell activation (GO:0001774)3.05846139
56positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.05694748
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01978253
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.00735619
59cellular potassium ion homeostasis (GO:0030007)2.97426232
60positive regulation of interferon-alpha production (GO:0032727)2.93888210
61membrane lipid catabolic process (GO:0046466)2.90570569
62interferon-gamma-mediated signaling pathway (GO:0060333)2.89749821
63regulation of mast cell activation (GO:0033003)2.89575423
64respiratory burst (GO:0045730)2.88664492
65myeloid dendritic cell differentiation (GO:0043011)2.87522835
66locomotory exploration behavior (GO:0035641)2.87410418
67alanine transport (GO:0032328)2.87238364
68sphingolipid catabolic process (GO:0030149)2.85935911
69germinal center formation (GO:0002467)2.84048664
70regulation of gamma-delta T cell activation (GO:0046643)2.82273896
71negative regulation of cell killing (GO:0031342)2.80270205
72negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80270205
73regulation of T-helper 2 cell differentiation (GO:0045628)2.79170943
74negative regulation of cytokine production involved in immune response (GO:0002719)2.78870227
75stress fiber assembly (GO:0043149)2.78511864
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77967147
77neutrophil activation (GO:0042119)2.77766087
78regulation of macrophage cytokine production (GO:0010935)2.77114872
79regulation of interferon-alpha production (GO:0032647)2.76244546
80L-amino acid import (GO:0043092)2.74389436
81regulation of early endosome to late endosome transport (GO:2000641)2.74064213
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.73275303
83positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72873619
84proline transport (GO:0015824)2.72361526
85macrophage activation (GO:0042116)2.70931567
86regulation of monocyte chemotaxis (GO:0090025)2.70001694
87regulation of antigen processing and presentation (GO:0002577)2.66836647
88positive regulation of cholesterol efflux (GO:0010875)2.65285905
89regulation of superoxide anion generation (GO:0032928)2.64570693
90regulation of macrophage chemotaxis (GO:0010758)2.63929912
91regulation of clathrin-mediated endocytosis (GO:2000369)2.63798923
92myeloid dendritic cell activation (GO:0001773)2.61699133
93peptide catabolic process (GO:0043171)2.61687629
94regulation of synapse structural plasticity (GO:0051823)2.61556107
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60541238
96regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60528085
97NIK/NF-kappaB signaling (GO:0038061)2.60013170
98regulation of T cell tolerance induction (GO:0002664)2.59622453
99regulation of podosome assembly (GO:0071801)2.59463659
100regulation of B cell receptor signaling pathway (GO:0050855)2.59443927
101positive regulation of regulated secretory pathway (GO:1903307)2.58721966
102clathrin coat assembly (GO:0048268)2.58603588
103keratan sulfate catabolic process (GO:0042340)2.58324296
104positive regulation of type 2 immune response (GO:0002830)2.55446810
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.54998669
106plasma membrane repair (GO:0001778)2.54795471
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54077883
108negative regulation of interleukin-17 production (GO:0032700)2.51368196
109cortical actin cytoskeleton organization (GO:0030866)2.50835270
110response to laminar fluid shear stress (GO:0034616)2.50069357
111type I interferon signaling pathway (GO:0060337)2.49052128
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48482048
113antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48482048
114activation of protein kinase A activity (GO:0034199)2.46273672
115I-kappaB phosphorylation (GO:0007252)2.46138739
116semaphorin-plexin signaling pathway (GO:0071526)2.43575404
117macroautophagy (GO:0016236)2.43502869
118neutrophil activation involved in immune response (GO:0002283)2.43366879
119lipoprotein transport (GO:0042953)2.43349130
120positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.41581776
121regulation of leukocyte degranulation (GO:0043300)2.40689985
122potassium ion import (GO:0010107)2.40583481
123myeloid cell activation involved in immune response (GO:0002275)2.38970026
124regulation of ARF GTPase activity (GO:0032312)2.37232339
125response to lipoprotein particle (GO:0055094)2.37134697
126positive regulation of antigen processing and presentation (GO:0002579)2.37040656
127positive regulation of leukocyte degranulation (GO:0043302)2.36904656
128cell adhesion mediated by integrin (GO:0033627)2.35262818
129regulation of regulated secretory pathway (GO:1903305)2.34997191
130phagosome maturation (GO:0090382)2.34968577
131regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33609548
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33545196
133antigen processing and presentation of endogenous antigen (GO:0019883)2.33253171
134amino acid import (GO:0043090)2.32773820
135positive regulation of bone resorption (GO:0045780)2.32525935
136positive regulation of bone remodeling (GO:0046852)2.32525935
137barbed-end actin filament capping (GO:0051016)2.30517427
138receptor catabolic process (GO:0032801)2.29686920
139L-alpha-amino acid transmembrane transport (GO:1902475)2.28446296
140immunoglobulin mediated immune response (GO:0016064)2.28207028
141cerebellar Purkinje cell layer development (GO:0021680)2.26168507
142positive regulation of mast cell activation (GO:0033005)2.24502555
143regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24391399
144layer formation in cerebral cortex (GO:0021819)2.24163415
145positive regulation of p38MAPK cascade (GO:1900745)2.24015546
146positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.20346431
147neuromuscular process controlling balance (GO:0050885)2.19559322
148phagocytosis (GO:0006909)2.19224863
149adenosine receptor signaling pathway (GO:0001973)2.18293988
150synaptic vesicle exocytosis (GO:0016079)2.17138179
151cortical cytoskeleton organization (GO:0030865)2.16429630
152cellular response to thyroid hormone stimulus (GO:0097067)2.14058907
153positive regulation of phagocytosis (GO:0050766)2.10691995
154regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.09778272
155negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.07844461
156cell communication by electrical coupling (GO:0010644)2.07509084
157regulation of beta-amyloid formation (GO:1902003)2.06283854
158synaptic vesicle docking involved in exocytosis (GO:0016081)2.05947877
159pinocytosis (GO:0006907)2.05841918
160G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.05223594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.19104216
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78283997
3* IRF8_27001747_Chip-Seq_BMDM_Mouse2.63637818
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51524379
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49680899
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.37226404
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27483062
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17305988
9* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15013328
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94532709
11SPI1_23127762_ChIP-Seq_K562_Human1.90219053
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89677708
13LXR_22292898_ChIP-Seq_THP-1_Human1.89263315
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85716993
15STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85632176
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84652419
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.82290523
18KDM2B_26808549_Chip-Seq_DND41_Human1.80875018
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80451251
20* SPI1_23547873_ChIP-Seq_NB4_Human1.80350986
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.79329854
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74684604
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72319559
24DROSHA_22980978_ChIP-Seq_HELA_Human1.72025389
25GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70142603
26* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67403074
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65784665
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65723108
29* KDM2B_26808549_Chip-Seq_K562_Human1.65701963
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.64982090
31SCL_19346495_ChIP-Seq_HPC-7_Human1.62257052
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58830950
33* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58171478
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57504177
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56773284
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.56541731
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55702004
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55318102
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.50991759
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49607612
41TCF7_22412390_ChIP-Seq_EML_Mouse1.47662091
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47549636
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.47514777
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45567769
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44958347
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44714921
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44144403
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.43563134
49* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42702735
50EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42142137
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39896386
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38786451
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38718543
54CLOCK_20551151_ChIP-Seq_293T_Human1.37836688
55* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37808442
56* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37363237
57* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35364052
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34565845
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32286572
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30854748
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30806406
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30772543
63VDR_21846776_ChIP-Seq_THP-1_Human1.29061226
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.28844219
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28536623
66* GATA1_19941826_ChIP-Seq_K562_Human1.27198124
67* GATA2_21666600_ChIP-Seq_HMVEC_Human1.25901094
68* VDR_24787735_ChIP-Seq_THP-1_Human1.24810748
69RACK7_27058665_Chip-Seq_MCF-7_Human1.23259716
70VDR_24763502_ChIP-Seq_THP-1_Human1.22879107
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21808203
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.21761756
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.21465873
74* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20523876
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19341723
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.18834731
77* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18087648
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17833115
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16660317
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15780277
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14951062
82UTX_26944678_Chip-Seq_JUKART_Human1.14666611
83TFEB_21752829_ChIP-Seq_HELA_Human1.14535801
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14165507
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.14088888
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13566732
87* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12430898
88* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11509318
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11137587
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.11032961
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10400604
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10141024
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09769077
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08724916
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07050906
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05599299
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05388177
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05126003
99RUNX_20019798_ChIP-Seq_JUKART_Human1.03231214
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03203597
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02613828
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.02056259
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98890903
104RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98630791
105EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98630791
106* RXR_22158963_ChIP-Seq_LIVER_Mouse0.98431150
107MAF_26560356_Chip-Seq_TH2_Human0.98319301
108ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98294617
109* GATA2_19941826_ChIP-Seq_K562_Human0.96242887
110RXR_22108803_ChIP-Seq_LS180_Human0.96046768
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95355148
112MYB_26560356_Chip-Seq_TH2_Human0.95327268
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93870295
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93521456
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93011157
116* MAF_26560356_Chip-Seq_TH1_Human0.92653280
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92651625
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92603427
119TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92376832
120GATA1_22025678_ChIP-Seq_K562_Human0.91861944
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91811947
122SMC4_20622854_ChIP-Seq_HELA_Human0.91806404
123* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91340226
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.90532889
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.90532889
126* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89302964
127RUNX1_22412390_ChIP-Seq_EML_Mouse0.89196833
128MYC_22102868_ChIP-Seq_BL_Human0.89084473
129* MITF_21258399_ChIP-Seq_MELANOMA_Human0.87888547
130* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87408083
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87156435
132* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87099193
133* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87057239
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87027564
135* PU_27001747_Chip-Seq_BMDM_Mouse0.86790005
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86583866
137* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86399272
138BCOR_27268052_Chip-Seq_Bcells_Human0.85095261
139* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84431052
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84311292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.23060519
2MP0003172_abnormal_lysosome_physiology4.09103157
3MP0003303_peritoneal_inflammation3.87253971
4MP0003724_increased_susceptibility_to3.35038527
5MP0004859_abnormal_synaptic_plasticity3.34857807
6MP0000569_abnormal_digit_pigmentation2.97908795
7MP0009840_abnormal_foam_cell2.73200383
8MP0000604_amyloidosis2.68235827
9MP0003300_gastrointestinal_ulcer2.67113025
10MP0004858_abnormal_nervous_system2.63644251
11MP0004510_myositis2.63084766
12MP0009785_altered_susceptibility_to2.38034512
13MP0003191_abnormal_cellular_cholesterol2.36688553
14MP0003705_abnormal_hypodermis_morpholog2.32067054
15MP0006082_CNS_inflammation2.31038627
16MP0003075_altered_response_to2.21402265
17* MP0003690_abnormal_glial_cell2.19482898
18MP0005671_abnormal_response_to2.17431779
19MP0005451_abnormal_body_composition2.10865013
20MP0004130_abnormal_muscle_cell2.10002835
21MP0003329_amyloid_beta_deposits1.98351418
22MP0008438_abnormal_cutaneous_collagen1.95789475
23MP0005167_abnormal_blood-brain_barrier1.95090896
24MP0008260_abnormal_autophagy1.89507934
25MP0005257_abnormal_intraocular_pressure1.86133907
26MP0001958_emphysema1.81769767
27MP0002909_abnormal_adrenal_gland1.76217337
28MP0003436_decreased_susceptibility_to1.74448461
29MP0001835_abnormal_antigen_presentation1.72035663
30MP0003566_abnormal_cell_adhesion1.70465219
31* MP0002419_abnormal_innate_immunity1.68153266
32MP0003828_pulmonary_edema1.67079423
33MP0003183_abnormal_peptide_metabolism1.58937969
34MP0009764_decreased_sensitivity_to1.58344415
35MP0001853_heart_inflammation1.55077500
36MP0008961_abnormal_basal_metabolism1.54137190
37MP0002090_abnormal_vision1.53489036
38MP0000858_altered_metastatic_potential1.50933081
39MP0002139_abnormal_hepatobiliary_system1.48226054
40MP0008004_abnormal_stomach_pH1.43813424
41MP0005166_decreased_susceptibility_to1.41152218
42MP0003045_fibrosis1.39955470
43MP0009780_abnormal_chondrocyte_physiolo1.39530214
44MP0005464_abnormal_platelet_physiology1.37412652
45MP0001533_abnormal_skeleton_physiology1.34904051
46MP0002998_abnormal_bone_remodeling1.31569293
47MP0010155_abnormal_intestine_physiology1.31431907
48MP0003453_abnormal_keratinocyte_physiol1.31090244
49* MP0003635_abnormal_synaptic_transmissio1.30096593
50MP0006054_spinal_hemorrhage1.29378958
51* MP0003634_abnormal_glial_cell1.28545214
52MP0005000_abnormal_immune_tolerance1.26911160
53MP0001545_abnormal_hematopoietic_system1.26777265
54MP0005397_hematopoietic_system_phenotyp1.26777265
55MP0004185_abnormal_adipocyte_glucose1.26537118
56MP0005310_abnormal_salivary_gland1.23547006
57MP0000343_altered_response_to1.22684649
58* MP0002064_seizures1.22676353
59MP0009278_abnormal_bone_marrow1.19984257
60MP0004947_skin_inflammation1.19914581
61MP0003091_abnormal_cell_migration1.19760007
62MP0001790_abnormal_immune_system1.16409131
63MP0005387_immune_system_phenotype1.16409131
64MP0009046_muscle_twitch1.16046823
65MP0004883_abnormal_blood_vessel1.14451102
66MP0003448_altered_tumor_morphology1.13933349
67MP0010307_abnormal_tumor_latency1.13880310
68* MP0003633_abnormal_nervous_system1.07181989
69MP0000013_abnormal_adipose_tissue1.06950668
70MP0010234_abnormal_vibrissa_follicle1.06267126
71* MP0000716_abnormal_immune_system1.04944136
72* MP0002452_abnormal_antigen_presenting1.04584134
73MP0005076_abnormal_cell_differentiation1.04105157
74MP0009333_abnormal_splenocyte_physiolog1.03613875
75MP0001851_eye_inflammation1.01203280
76MP0005025_abnormal_response_to0.98634599
77MP0001501_abnormal_sleep_pattern0.97543104
78MP0003806_abnormal_nucleotide_metabolis0.95066658
79* MP0000920_abnormal_myelination0.93472048
80MP0000751_myopathy0.92378052
81MP0005165_increased_susceptibility_to0.92185028
82MP0005390_skeleton_phenotype0.91867609
83MP0002254_reproductive_system_inflammat0.91271681
84MP0005670_abnormal_white_adipose0.90723235
85MP0002063_abnormal_learning/memory/cond0.88526025
86MP0004270_analgesia0.86373441
87MP0001849_ear_inflammation0.84279567
88MP0005375_adipose_tissue_phenotype0.84132622
89MP0009763_increased_sensitivity_to0.83313531
90MP0005666_abnormal_adipose_tissue0.81747951
91MP0002332_abnormal_exercise_endurance0.81234200
92MP0002398_abnormal_bone_marrow0.80666236
93MP0002723_abnormal_immune_serum0.80150437
94MP0005365_abnormal_bile_salt0.79221635
95MP0000685_abnormal_immune_system0.78579585
96MP0000003_abnormal_adipose_tissue0.78184890
97* MP0002429_abnormal_blood_cell0.78067892
98* MP0001819_abnormal_immune_cell0.75897074
99MP0001542_abnormal_bone_strength0.75780317
100* MP0001845_abnormal_inflammatory_respons0.75491728
101* MP0000689_abnormal_spleen_morphology0.75429745
102MP0003283_abnormal_digestive_organ0.75047286
103MP0002877_abnormal_melanocyte_morpholog0.74857059
104MP0010329_abnormal_lipoprotein_level0.74632263
105* MP0002420_abnormal_adaptive_immunity0.73867159
106MP0008469_abnormal_protein_level0.73490525
107MP0009745_abnormal_behavioral_response0.72481499
108MP0001800_abnormal_humoral_immune0.70735691
109* MP0003631_nervous_system_phenotype0.70039451
110* MP0004811_abnormal_neuron_physiology0.69931612
111* MP0002722_abnormal_immune_system0.68005923
112MP0002148_abnormal_hypersensitivity_rea0.67639510
113MP0005535_abnormal_body_temperature0.67087908
114MP0001663_abnormal_digestive_system0.66574271
115MP0003656_abnormal_erythrocyte_physiolo0.66414542
116MP0000371_diluted_coat_color0.66238139
117MP0003279_aneurysm0.65243793
118MP0002168_other_aberrant_phenotype0.64995962
119* MP0008569_lethality_at_weaning0.64514045
120MP0008874_decreased_physiological_sensi0.63886054
121MP0000249_abnormal_blood_vessel0.63412296
122MP0005623_abnormal_meninges_morphology0.63305932
123MP0002971_abnormal_brown_adipose0.62563097
124MP0002405_respiratory_system_inflammati0.62153128
125MP0002733_abnormal_thermal_nociception0.62109697
126MP0005023_abnormal_wound_healing0.62102546
127MP0000733_abnormal_muscle_development0.60769140
128* MP0001756_abnormal_urination0.59429671
129MP0005275_abnormal_skin_tensile0.59370366
130MP0005164_abnormal_response_to0.58117673
131MP0002896_abnormal_bone_mineralization0.57251577
132MP0005595_abnormal_vascular_smooth0.56541287
133MP0003795_abnormal_bone_structure0.56508202
134* MP0003632_abnormal_nervous_system0.56455542
135MP0001915_intracranial_hemorrhage0.56056972
136MP0001440_abnormal_grooming_behavior0.56034265
137MP0000465_gastrointestinal_hemorrhage0.55329742
138MP0002933_joint_inflammation0.52562624
139MP0005319_abnormal_enzyme/_coenzyme0.51578027

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)4.95589288
2Increased neuronal autofluorescent lipopigment (HP:0002074)4.91694852
3* Increased cerebral lipofuscin (HP:0011813)4.91694852
4Vacuolated lymphocytes (HP:0001922)4.41413934
5Urinary glycosaminoglycan excretion (HP:0003541)4.26144706
6Mucopolysacchariduria (HP:0008155)4.26144706
7Abnormality of mucopolysaccharide metabolism (HP:0011020)4.08814368
8Abnormality of polysaccharide metabolism (HP:0011012)4.08814368
9Abnormality of glycosaminoglycan metabolism (HP:0004371)4.08814368
10Supranuclear gaze palsy (HP:0000605)3.65020740
11Systemic lupus erythematosus (HP:0002725)3.53871711
12Axonal loss (HP:0003447)3.48430136
13Disinhibition (HP:0000734)3.48067617
14Orchitis (HP:0100796)3.38700561
15Recurrent abscess formation (HP:0002722)3.36876326
16Mutism (HP:0002300)3.30690724
17Cerebral aneurysm (HP:0004944)3.27601529
18Myositis (HP:0100614)3.25990962
19Mediastinal lymphadenopathy (HP:0100721)3.21984163
20Abnormality of macrophages (HP:0004311)3.16031100
21Retrobulbar optic neuritis (HP:0100654)3.11487648
22Optic neuritis (HP:0100653)3.11487648
23Asymmetric septal hypertrophy (HP:0001670)3.06889743
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.02643168
25Nuclear cataract (HP:0100018)3.02071033
26Apathy (HP:0000741)3.00004058
27Recurrent gram-negative bacterial infections (HP:0005420)2.96446183
28Eczematoid dermatitis (HP:0000976)2.94230993
29Neurofibrillary tangles (HP:0002185)2.91310088
30Diminished motivation (HP:0000745)2.90658226
31Recurrent bacterial skin infections (HP:0005406)2.79643811
32Purpura (HP:0000979)2.79107576
33Cerebral inclusion bodies (HP:0100314)2.76421788
34* Abnormality of liposaccharide metabolism (HP:0010968)2.74323204
35* Abnormality of glycosphingolipid metabolism (HP:0004343)2.74323204
36* Abnormality of glycolipid metabolism (HP:0010969)2.74323204
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60890572
38Obstructive lung disease (HP:0006536)2.60669299
39Chronic obstructive pulmonary disease (HP:0006510)2.60669299
40* Neuronal loss in central nervous system (HP:0002529)2.59693829
41Stomatitis (HP:0010280)2.59079605
42Upper limb amyotrophy (HP:0009129)2.50950303
43Distal upper limb amyotrophy (HP:0007149)2.50950303
44J-shaped sella turcica (HP:0002680)2.47848424
45Glomerulonephritis (HP:0000099)2.47736788
46Myocardial infarction (HP:0001658)2.43500874
47Vertebral compression fractures (HP:0002953)2.42597787
48* Loss of speech (HP:0002371)2.41432227
49Hand muscle atrophy (HP:0009130)2.40847749
50Spontaneous hematomas (HP:0007420)2.35682435
51Retinal atrophy (HP:0001105)2.34953490
52Papilledema (HP:0001085)2.28696726
53Inappropriate behavior (HP:0000719)2.28345134
54Hematochezia (HP:0002573)2.25542159
55Increased serum ferritin (HP:0003281)2.24072895
56Pulmonary infiltrates (HP:0002113)2.24006604
57Frequent falls (HP:0002359)2.22278273
58Visual hallucinations (HP:0002367)2.21843929
59Striae distensae (HP:0001065)2.16095826
60Personality changes (HP:0000751)2.15878669
61Recurrent fungal infections (HP:0002841)2.14114035
62Agnosia (HP:0010524)2.13703629
63Keratoconjunctivitis sicca (HP:0001097)2.12695253
64Urticaria (HP:0001025)2.10795718
65Rapidly progressive (HP:0003678)2.10377701
66Action tremor (HP:0002345)2.08877363
67Abnormality of binocular vision (HP:0011514)2.08755682
68Diplopia (HP:0000651)2.08755682
69Gingivitis (HP:0000230)2.06120724
70Arterial tortuosity (HP:0005116)2.04728704
71Thoracic kyphosis (HP:0002942)1.99098078
72Autoimmune thrombocytopenia (HP:0001973)1.99085208
73Upper motor neuron abnormality (HP:0002127)1.99026583
74Abnormality of the lumbar spine (HP:0100712)1.98629248
75* Hepatosplenomegaly (HP:0001433)1.96003104
76Dementia (HP:0000726)1.94916006
77Hemoptysis (HP:0002105)1.94392139
78Ovoid vertebral bodies (HP:0003300)1.94363191
79Postural instability (HP:0002172)1.94187820
80Complement deficiency (HP:0004431)1.92724365
81Meningitis (HP:0001287)1.92693116
82Cervical subluxation (HP:0003308)1.92643320
83Petechiae (HP:0000967)1.91959830
84Elevated erythrocyte sedimentation rate (HP:0003565)1.91945852
85Nephritis (HP:0000123)1.89581254
86Bone pain (HP:0002653)1.89123188
87Achilles tendon contracture (HP:0001771)1.88660022
88Vascular tortuosity (HP:0004948)1.86471279
89Keratoconjunctivitis (HP:0001096)1.85869995
90Prolonged neonatal jaundice (HP:0006579)1.83582886
91Interstitial pulmonary disease (HP:0006530)1.82653238
92Vasculitis (HP:0002633)1.82309797
93Hemiplegia (HP:0002301)1.78477835
94Abnormal eating behavior (HP:0100738)1.77426746
95Memory impairment (HP:0002354)1.77353603
96Myokymia (HP:0002411)1.76842551
97Basal ganglia calcification (HP:0002135)1.76063812
98Abnormality of iron homeostasis (HP:0011031)1.75261389
99Malnutrition (HP:0004395)1.74419062
100Long toe (HP:0010511)1.73536707
101Focal seizures (HP:0007359)1.72735199
102Abnormality of complement system (HP:0005339)1.72586451
103Restrictive lung disease (HP:0002091)1.72575476
104Abnormality of the Achilles tendon (HP:0005109)1.72242697
105Turricephaly (HP:0000262)1.71877819
106Polygenic inheritance (HP:0010982)1.70150872
107Recurrent viral infections (HP:0004429)1.69896455
108Hyperacusis (HP:0010780)1.69732613
109Xanthomatosis (HP:0000991)1.69369974
110Increased IgE level (HP:0003212)1.69228928
111Cellulitis (HP:0100658)1.68811211
112T lymphocytopenia (HP:0005403)1.68012952
113Aortic aneurysm (HP:0004942)1.66461736
114Deformed sella turcica (HP:0002681)1.65930508
115Gingival bleeding (HP:0000225)1.65177695
116Arterial thrombosis (HP:0004420)1.65134264
117Progressive visual loss (HP:0000529)1.65084710
118Cardiomegaly (HP:0001640)1.63960299
119Mitral valve prolapse (HP:0001634)1.63793215
120Segmental peripheral demyelination/remyelination (HP:0003481)1.63582519
121Gastrointestinal infarctions (HP:0005244)1.63533747
122Spondylolisthesis (HP:0003302)1.62926362
123Depression (HP:0000716)1.62696991
124Recurrent cutaneous fungal infections (HP:0011370)1.62232435
125Chronic mucocutaneous candidiasis (HP:0002728)1.62232435
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.62185682
127Osteomyelitis (HP:0002754)1.62043200
128Slow saccadic eye movements (HP:0000514)1.61993941
129Acrocyanosis (HP:0001063)1.61584040
130Neurodegeneration (HP:0002180)1.61539804
131Dilatation of the ascending aorta (HP:0005111)1.60258818
132Abnormality of the thoracic spine (HP:0100711)1.60132705
133Colitis (HP:0002583)1.58924982
134Amyloidosis (HP:0011034)1.58703211
135Bundle branch block (HP:0011710)1.58457352
136Pathologic fracture (HP:0002756)1.57293170
137Conjunctival telangiectasia (HP:0000524)1.56242535
138* Increased CSF protein (HP:0002922)1.56097178
139Aneurysm (HP:0002617)1.55070158
140Recurrent skin infections (HP:0001581)1.54921909
141Sensorimotor neuropathy (HP:0007141)1.54638014
142Shallow orbits (HP:0000586)1.54423461
143Coarse hair (HP:0002208)1.54394979
144Macroorchidism (HP:0000053)1.54209802
145Protuberant abdomen (HP:0001538)1.53485989
146Progressive neurologic deterioration (HP:0002344)1.53478862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.24904770
2IRAK33.05431016
3RIPK43.02776060
4PRPF4B2.97010656
5MAP3K92.76586650
6ERN12.68469513
7PKN22.54447039
8RIPK12.51457804
9KSR22.32670557
10MAP3K142.30781791
11CAMKK12.18941651
12SCYL22.10555492
13MAP3K32.03493662
14TTN2.00003922
15GRK71.98145261
16DAPK21.94194647
17CAMK1D1.82812909
18TAOK21.79964292
19IRAK41.78970467
20MAP3K111.78801393
21PAK61.76227863
22CAMK1G1.71635651
23NTRK11.65026694
24NME21.63754495
25TGFBR21.58517198
26FES1.57969364
27PTK61.56315201
28CAMKK21.55661800
29KIT1.54597651
30PRKD31.52545650
31TBK11.51435647
32PRKCH1.50025888
33JAK11.46394283
34EPHB11.46173283
35MAP3K21.41069218
36TYK21.39717508
37JAK31.37074297
38MAP3K131.35048466
39SIK21.32962853
40NTRK31.32079847
41BLK1.31569441
42PDGFRA1.30081085
43RET1.23081777
44STK381.21581542
45BMX1.21149785
46ALK1.19475017
47TESK21.11417150
48LMTK21.10141585
49JAK21.07119464
50BMPR21.06531019
51IKBKE1.06015118
52PDPK11.04890310
53TAOK11.04042378
54HCK1.01369174
55LRRK20.98868622
56MINK10.98738690
57PAK40.98123808
58IKBKB0.97980259
59CSF1R0.97950384
60IRAK20.97124326
61FGR0.97024664
62TESK10.96668703
63PDK10.92584352
64LYN0.91313666
65PIM20.90681798
66MAP3K10.90047513
67SIK10.86614704
68DDR20.84609982
69SGK30.83648528
70TYRO30.81405358
71EPHA40.81106941
72MARK20.78768154
73DMPK0.77288684
74CDK50.76852501
75BTK0.74389052
76CSK0.74220339
77TNK20.74110194
78MAP4K10.73300813
79EEF2K0.73293164
80FYN0.73131727
81LCK0.72491748
82MAP3K50.72109722
83PDGFRB0.71701464
84CDK60.70385146
85SIK30.69256264
86MAPK70.68184983
87EPHA30.67525031
88PDK20.66800000
89MATK0.66307795
90PTK2B0.65678234
91PTK20.64838408
92NTRK20.63736877
93MAPK120.62845193
94STK100.62511185
95FGFR30.61708636
96IRAK10.61135337
97MAP2K30.60769876
98EGFR0.60724897
99MARK30.60343702
100TAOK30.59201829
101MOS0.56841634
102MAP3K60.56415902
103DAPK30.55101831
104RPS6KA20.54934463
105MAP2K10.54586460
106MARK10.54541253
107TXK0.54308801
108SYK0.54186523
109FGFR40.53453814
110PRKD20.53014176
111MAP2K40.52940700
112PRKD10.52244568
113ICK0.51653933
114RPS6KC10.50879675
115RPS6KL10.50879675
116SRC0.50833691
117MAP3K100.49610596
118PHKG20.49254096
119PHKG10.49254096
120ZAP700.48367535
121KSR10.48116438
122YES10.46798683
123DAPK10.46771985
124CHUK0.45591492
125ACVR1B0.44284230
126ARAF0.44182894
127ABL20.43595854
128MAP3K40.43540484
129STK110.43318867
130NEK90.42005979
131CDC42BPA0.41555857
132PAK20.40057078
133GRK60.39586455
134LATS20.38590740
135DYRK1B0.38585817
136CAMK40.37572560
137MAPK40.36377416
138ABL10.35364792
139PAK30.34568130
140NEK10.34556057
141SGK10.34393937
142CAMK10.34242553
143WNK10.34076162
144FER0.32273985

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.93072145
2* Lysosome_Homo sapiens_hsa041422.83744327
3Synaptic vesicle cycle_Homo sapiens_hsa047211.93824615
4Allograft rejection_Homo sapiens_hsa053301.90974620
5Other glycan degradation_Homo sapiens_hsa005111.81543064
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.74477908
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70922922
8Graft-versus-host disease_Homo sapiens_hsa053321.70670995
9Autoimmune thyroid disease_Homo sapiens_hsa053201.63405778
10Staphylococcus aureus infection_Homo sapiens_hsa051501.62426650
11Nitrogen metabolism_Homo sapiens_hsa009101.62278628
12Asthma_Homo sapiens_hsa053101.60868805
13Osteoclast differentiation_Homo sapiens_hsa043801.59268795
14Tuberculosis_Homo sapiens_hsa051521.49216340
15Legionellosis_Homo sapiens_hsa051341.45659165
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43205063
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43179583
18Type II diabetes mellitus_Homo sapiens_hsa049301.41740468
19Collecting duct acid secretion_Homo sapiens_hsa049661.40909845
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.40526563
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39246688
22Leishmaniasis_Homo sapiens_hsa051401.37536683
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33618978
24Phagosome_Homo sapiens_hsa041451.31888959
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28347633
26Type I diabetes mellitus_Homo sapiens_hsa049401.27641283
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.25380393
28Viral myocarditis_Homo sapiens_hsa054161.21882490
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20074383
30B cell receptor signaling pathway_Homo sapiens_hsa046621.19099377
31Influenza A_Homo sapiens_hsa051641.19089994
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15392699
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14730602
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13146158
35Glioma_Homo sapiens_hsa052141.13075185
36Hematopoietic cell lineage_Homo sapiens_hsa046401.12967264
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11632138
38Olfactory transduction_Homo sapiens_hsa047401.10826902
39Gastric acid secretion_Homo sapiens_hsa049711.09899115
40Pertussis_Homo sapiens_hsa051331.07393891
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04878813
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.04545966
43Endocytosis_Homo sapiens_hsa041441.04533813
44Acute myeloid leukemia_Homo sapiens_hsa052211.01656310
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98070998
46Salivary secretion_Homo sapiens_hsa049700.97630370
47Amoebiasis_Homo sapiens_hsa051460.95537468
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94731017
49mTOR signaling pathway_Homo sapiens_hsa041500.94411432
50Estrogen signaling pathway_Homo sapiens_hsa049150.94253703
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94000908
52Long-term potentiation_Homo sapiens_hsa047200.93683865
53Chronic myeloid leukemia_Homo sapiens_hsa052200.93179470
54VEGF signaling pathway_Homo sapiens_hsa043700.92736737
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92487423
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92166076
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.91017895
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88109144
59Hepatitis C_Homo sapiens_hsa051600.87787568
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87756111
61Salmonella infection_Homo sapiens_hsa051320.87464004
62Chemokine signaling pathway_Homo sapiens_hsa040620.87272886
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87042659
64Measles_Homo sapiens_hsa051620.87042217
65Circadian entrainment_Homo sapiens_hsa047130.85658946
66Renin secretion_Homo sapiens_hsa049240.85394710
67Rheumatoid arthritis_Homo sapiens_hsa053230.84368426
68GnRH signaling pathway_Homo sapiens_hsa049120.84311186
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.84151215
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83745116
71Complement and coagulation cascades_Homo sapiens_hsa046100.83005922
72Toxoplasmosis_Homo sapiens_hsa051450.82969068
73Vibrio cholerae infection_Homo sapiens_hsa051100.82804626
74Dorso-ventral axis formation_Homo sapiens_hsa043200.82464178
75GABAergic synapse_Homo sapiens_hsa047270.81964128
76African trypanosomiasis_Homo sapiens_hsa051430.81490892
77Galactose metabolism_Homo sapiens_hsa000520.80762258
78Cholinergic synapse_Homo sapiens_hsa047250.80000469
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.79242028
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79140092
81Prion diseases_Homo sapiens_hsa050200.78901364
82Sphingolipid metabolism_Homo sapiens_hsa006000.78853843
83Proteoglycans in cancer_Homo sapiens_hsa052050.78212586
84Renal cell carcinoma_Homo sapiens_hsa052110.78024705
85Hepatitis B_Homo sapiens_hsa051610.77931749
86Platelet activation_Homo sapiens_hsa046110.77548807
87Insulin secretion_Homo sapiens_hsa049110.77447198
88Oxytocin signaling pathway_Homo sapiens_hsa049210.77172931
89Insulin resistance_Homo sapiens_hsa049310.77167120
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.76844550
91Bladder cancer_Homo sapiens_hsa052190.75447833
92Morphine addiction_Homo sapiens_hsa050320.74901655
93Pancreatic cancer_Homo sapiens_hsa052120.74747496
94Herpes simplex infection_Homo sapiens_hsa051680.74160382
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.73621888
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72885249
97Malaria_Homo sapiens_hsa051440.72550866
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71844844
99Non-small cell lung cancer_Homo sapiens_hsa052230.70904281
100Focal adhesion_Homo sapiens_hsa045100.70520606
101Glutamatergic synapse_Homo sapiens_hsa047240.70278552
102T cell receptor signaling pathway_Homo sapiens_hsa046600.68650596
103Dilated cardiomyopathy_Homo sapiens_hsa054140.68395416
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68171458
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67505984
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67056993
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66829677
108Shigellosis_Homo sapiens_hsa051310.65389021
109Bile secretion_Homo sapiens_hsa049760.64214780
110Insulin signaling pathway_Homo sapiens_hsa049100.63960143
111Antigen processing and presentation_Homo sapiens_hsa046120.63770784
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63259112
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63113731
114Notch signaling pathway_Homo sapiens_hsa043300.62332416
115cAMP signaling pathway_Homo sapiens_hsa040240.60960795
116Prolactin signaling pathway_Homo sapiens_hsa049170.60943392
117Caffeine metabolism_Homo sapiens_hsa002320.60898456
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59924348
119Gap junction_Homo sapiens_hsa045400.59744872
120Dopaminergic synapse_Homo sapiens_hsa047280.59396975
121Endometrial cancer_Homo sapiens_hsa052130.57552756
122HIF-1 signaling pathway_Homo sapiens_hsa040660.57457240
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.56950582
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56854403
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56835879
126Apoptosis_Homo sapiens_hsa042100.55914933
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54957828
128PPAR signaling pathway_Homo sapiens_hsa033200.54317078
129TNF signaling pathway_Homo sapiens_hsa046680.53381320
130ErbB signaling pathway_Homo sapiens_hsa040120.53038136
131Long-term depression_Homo sapiens_hsa047300.52890455
132Inositol phosphate metabolism_Homo sapiens_hsa005620.52670330
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48551008
134Fructose and mannose metabolism_Homo sapiens_hsa000510.45909268
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43435793
136Mineral absorption_Homo sapiens_hsa049780.37716792
137Pentose phosphate pathway_Homo sapiens_hsa000300.36546704
138Epstein-Barr virus infection_Homo sapiens_hsa051690.32212131
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31550696

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