PSAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.13705244
2central nervous system myelination (GO:0022010)7.13705244
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.05605463
4establishment of integrated proviral latency (GO:0075713)5.02083375
5ribosome assembly (GO:0042255)4.40331603
6protein localization to kinetochore (GO:0034501)4.15800516
7DNA unwinding involved in DNA replication (GO:0006268)4.15735796
8mitotic metaphase plate congression (GO:0007080)3.95891551
9DNA replication initiation (GO:0006270)3.79576315
10axon ensheathment (GO:0008366)3.79443338
11ensheathment of neurons (GO:0007272)3.79443338
12myelination (GO:0042552)3.77482105
13nucleobase biosynthetic process (GO:0046112)3.76217806
14establishment of viral latency (GO:0019043)3.73890399
15positive regulation of chromosome segregation (GO:0051984)3.72732702
16regulation of spindle organization (GO:0090224)3.70381892
17DNA strand elongation involved in DNA replication (GO:0006271)3.67679095
18DNA replication-dependent nucleosome assembly (GO:0006335)3.66828904
19DNA replication-dependent nucleosome organization (GO:0034723)3.66828904
20formation of translation preinitiation complex (GO:0001731)3.66606857
21* serine family amino acid biosynthetic process (GO:0009070)3.57211779
22purine nucleobase biosynthetic process (GO:0009113)3.54761815
23tRNA aminoacylation for protein translation (GO:0006418)3.49524749
24regulation of exit from mitosis (GO:0007096)3.49422305
25DNA strand elongation (GO:0022616)3.44931343
26fatty acid elongation (GO:0030497)3.43854699
27heterochromatin organization (GO:0070828)3.41681217
28amino acid activation (GO:0043038)3.41200499
29tRNA aminoacylation (GO:0043039)3.41200499
30protein localization to chromosome, centromeric region (GO:0071459)3.40726236
31mitotic nuclear envelope disassembly (GO:0007077)3.32576179
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31820554
33IMP biosynthetic process (GO:0006188)3.31528164
34myelin maintenance (GO:0043217)3.30486218
35nuclear pore organization (GO:0006999)3.30452516
36DNA ligation (GO:0006266)3.28446928
37DNA replication checkpoint (GO:0000076)3.28116477
38regulation of mitotic spindle organization (GO:0060236)3.26599820
39double-strand break repair via nonhomologous end joining (GO:0006303)3.26373523
40non-recombinational repair (GO:0000726)3.26373523
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.26142606
42DNA double-strand break processing (GO:0000729)3.25067181
43mitotic sister chromatid segregation (GO:0000070)3.23853617
44metaphase plate congression (GO:0051310)3.23582359
45maturation of SSU-rRNA (GO:0030490)3.22697757
46IMP metabolic process (GO:0046040)3.19885046
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18819834
48regulation of helicase activity (GO:0051095)3.16653577
49regulation of mitotic sister chromatid separation (GO:0010965)3.12280902
50regulation of mitotic sister chromatid segregation (GO:0033047)3.12280902
51regulation of sister chromatid segregation (GO:0033045)3.12280902
52nuclear envelope disassembly (GO:0051081)3.12059127
53membrane disassembly (GO:0030397)3.12059127
54folic acid-containing compound biosynthetic process (GO:0009396)3.10216773
55mitotic sister chromatid cohesion (GO:0007064)3.09989426
56spindle checkpoint (GO:0031577)3.09849453
57ribosome biogenesis (GO:0042254)3.09374361
58* L-serine metabolic process (GO:0006563)3.07780610
59glutamine metabolic process (GO:0006541)3.06846027
60glycine metabolic process (GO:0006544)3.06061507
61attachment of spindle microtubules to kinetochore (GO:0008608)3.05556182
62telomere maintenance via recombination (GO:0000722)3.04969169
63cholesterol biosynthetic process (GO:0006695)3.04798684
64CENP-A containing nucleosome assembly (GO:0034080)3.04753564
65regulation of chromosome segregation (GO:0051983)3.03298496
66mitotic spindle checkpoint (GO:0071174)3.02847532
67mitotic nuclear envelope reassembly (GO:0007084)3.01942225
68nuclear envelope reassembly (GO:0031468)3.01942225
69tetrahydrofolate metabolic process (GO:0046653)3.01681475
70ATP-dependent chromatin remodeling (GO:0043044)3.01611823
71ribosomal large subunit biogenesis (GO:0042273)3.01154159
72ribonucleoprotein complex biogenesis (GO:0022613)3.00856770
73sister chromatid segregation (GO:0000819)2.99575907
74cellular protein complex localization (GO:0034629)2.98399937
75DNA strand renaturation (GO:0000733)2.98386175
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96980004
77somatic hypermutation of immunoglobulin genes (GO:0016446)2.96980004
78telomere maintenance via semi-conservative replication (GO:0032201)2.95531219
79negative regulation of DNA-dependent DNA replication (GO:2000104)2.95047055
80negative regulation of mitosis (GO:0045839)2.94539179
81pre-miRNA processing (GO:0031054)2.94385903
82regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93860574
83regulation of mitotic spindle checkpoint (GO:1903504)2.93860574
84ribosomal small subunit biogenesis (GO:0042274)2.93345943
85rRNA processing (GO:0006364)2.93163593
86regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93023755
87chromatin remodeling at centromere (GO:0031055)2.92396165
88regulation of centriole replication (GO:0046599)2.92074088
89spindle assembly involved in mitosis (GO:0090307)2.91940084
90microtubule polymerization or depolymerization (GO:0031109)2.89982619
91negative regulation of chromosome segregation (GO:0051985)2.89953131
92mitotic spindle assembly checkpoint (GO:0007094)2.88369690
93lysine catabolic process (GO:0006554)2.88034373
94lysine metabolic process (GO:0006553)2.88034373
95nuclear pore complex assembly (GO:0051292)2.87932292
96spindle assembly checkpoint (GO:0071173)2.86911263
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.85167255
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85167255
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85167255
100negative regulation of sister chromatid segregation (GO:0033046)2.85167255
101DNA damage response, detection of DNA damage (GO:0042769)2.85118042
102regulation of centrosome cycle (GO:0046605)2.83539925
103nuclear envelope organization (GO:0006998)2.82937313
104pore complex assembly (GO:0046931)2.82387484
105protein complex localization (GO:0031503)2.81865969
106establishment of chromosome localization (GO:0051303)2.81173591
107long-chain fatty acid biosynthetic process (GO:0042759)2.80802407
108negative regulation of DNA recombination (GO:0045910)2.80637671
109spliceosomal snRNP assembly (GO:0000387)2.80520003
110anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80140945
111rRNA metabolic process (GO:0016072)2.79945090
112regulation of translational fidelity (GO:0006450)2.77977974
113telomere maintenance via telomere lengthening (GO:0010833)2.77762797
114DNA replication-independent nucleosome organization (GO:0034724)2.77682777
115DNA replication-independent nucleosome assembly (GO:0006336)2.77682777
116translational initiation (GO:0006413)2.76696452
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.75744404
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74199545
119negative regulation of ligase activity (GO:0051352)2.74199545
120kinetochore organization (GO:0051383)2.73806075
121mitotic chromosome condensation (GO:0007076)2.73651611
122paraxial mesoderm development (GO:0048339)2.73577455
123regulation of translational elongation (GO:0006448)2.72704212
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.72289336
125termination of RNA polymerase III transcription (GO:0006386)2.72289336
126histone-serine phosphorylation (GO:0035404)2.72225134
127chromatin assembly or disassembly (GO:0006333)2.72115583
128lung-associated mesenchyme development (GO:0060484)2.71457492
129sterol biosynthetic process (GO:0016126)2.70141161
130regulation of translational termination (GO:0006449)2.69185663
131microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.69163793
132response to X-ray (GO:0010165)2.68810689
133RNA-dependent DNA replication (GO:0006278)2.68106657
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68087341
135astrocyte development (GO:0014002)2.67835628
136establishment of mitochondrion localization (GO:0051654)2.66740842
137establishment of mitotic spindle localization (GO:0040001)2.65722412
138L-methionine salvage (GO:0071267)2.63538763
139L-methionine biosynthetic process (GO:0071265)2.63538763
140amino acid salvage (GO:0043102)2.63538763
141histone exchange (GO:0043486)2.63289425
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63157137
143chaperone-mediated protein complex assembly (GO:0051131)2.62671301
144proteasome assembly (GO:0043248)2.62349689
145mitotic recombination (GO:0006312)2.61869090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.42355548
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53544386
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37203529
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64777446
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.36111148
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.34808908
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24149915
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.24005535
9AR_21909140_ChIP-Seq_LNCAP_Human3.16821721
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16601700
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.15925116
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.95064951
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94205025
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92759757
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.82240166
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77528012
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77201075
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.64834719
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54717585
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54321070
21XRN2_22483619_ChIP-Seq_HELA_Human2.50662193
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48943247
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35918268
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19778698
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03109431
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02933398
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01219044
28VDR_23849224_ChIP-Seq_CD4+_Human1.98415767
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97290595
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97074808
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95832416
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95743195
33DCP1A_22483619_ChIP-Seq_HELA_Human1.88106183
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85903001
35TTF2_22483619_ChIP-Seq_HELA_Human1.74360263
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69777270
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69011235
38GABP_19822575_ChIP-Seq_HepG2_Human1.66293676
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.66289865
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66239535
41FOXP3_21729870_ChIP-Seq_TREG_Human1.57972661
42KDM5A_27292631_Chip-Seq_BREAST_Human1.56500616
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56419029
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56419029
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56419029
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55826067
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55645455
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53965870
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53911848
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53739802
51ELK1_19687146_ChIP-ChIP_HELA_Human1.49096760
52* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49015699
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45308125
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44133032
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39778976
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38757507
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36514625
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34909529
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33565361
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32047493
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31615881
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30420977
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29390963
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23528955
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22719348
66MYC_18940864_ChIP-ChIP_HL60_Human1.20693775
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19838026
68* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19799896
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18480088
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17986472
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17946128
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17422319
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.15802559
74TFEB_21752829_ChIP-Seq_HELA_Human1.15270480
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.13451862
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.10729659
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10351007
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.09953565
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08638309
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08393258
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05664249
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05562630
83ZNF263_19887448_ChIP-Seq_K562_Human1.05372424
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04803157
85EWS_26573619_Chip-Seq_HEK293_Human1.04604609
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03741180
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01252305
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00923568
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.00883332
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99638576
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.99414028
92NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98173939
93* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98085975
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.97445128
95CIITA_25753668_ChIP-Seq_RAJI_Human0.97281289
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95922613
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95677330
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95577816
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94944688
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.94623381
101* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94580307
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93785615
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93027269
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91535788
105* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91342096
106EGR1_19374776_ChIP-ChIP_THP-1_Human0.91146703
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.90323209
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89771353
109SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86968479
110FUS_26573619_Chip-Seq_HEK293_Human0.86177365
111ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84971358
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84394918
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.84286821
114POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84001600
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83764394
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82906027
117OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82636435
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82626812
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80806348
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80433699
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80033279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.61312131
2MP0004957_abnormal_blastocyst_morpholog3.45388446
3MP0003111_abnormal_nucleus_morphology3.44368602
4MP0003693_abnormal_embryo_hatching3.24175195
5MP0010094_abnormal_chromosome_stability3.20867254
6MP0003077_abnormal_cell_cycle2.91673884
7MP0008932_abnormal_embryonic_tissue2.86868364
8MP0008057_abnormal_DNA_replication2.85034820
9MP0003950_abnormal_plasma_membrane2.54207524
10MP0000920_abnormal_myelination2.54175652
11MP0010030_abnormal_orbit_morphology2.35906354
12MP0001730_embryonic_growth_arrest2.30023271
13MP0006292_abnormal_olfactory_placode2.12683674
14MP0002254_reproductive_system_inflammat1.96088440
15MP0005623_abnormal_meninges_morphology1.95638762
16MP0003136_yellow_coat_color1.92167266
17MP0000537_abnormal_urethra_morphology1.89982665
18MP0003937_abnormal_limbs/digits/tail_de1.89714376
19MP0000350_abnormal_cell_proliferation1.88590469
20MP0008438_abnormal_cutaneous_collagen1.85778202
21MP0008007_abnormal_cellular_replicative1.82101015
22MP0003123_paternal_imprinting1.81094721
23MP0003718_maternal_effect1.77921172
24MP0009697_abnormal_copulation1.73285743
25MP0001293_anophthalmia1.64898030
26MP0010678_abnormal_skin_adnexa1.64497319
27MP0000383_abnormal_hair_follicle1.64338550
28MP0002085_abnormal_embryonic_tissue1.62241978
29MP0002084_abnormal_developmental_patter1.59629240
30MP0008058_abnormal_DNA_repair1.59319060
31MP0001697_abnormal_embryo_size1.56735522
32MP0000579_abnormal_nail_morphology1.55419683
33MP0005380_embryogenesis_phenotype1.51945025
34MP0001672_abnormal_embryogenesis/_devel1.51945025
35MP0008260_abnormal_autophagy1.51025567
36MP0001529_abnormal_vocalization1.49334183
37MP0001485_abnormal_pinna_reflex1.45690599
38MP0000428_abnormal_craniofacial_morphol1.42908051
39MP0004185_abnormal_adipocyte_glucose1.42682540
40MP0003938_abnormal_ear_development1.41915532
41MP0002080_prenatal_lethality1.41177784
42MP0000733_abnormal_muscle_development1.39138692
43MP0005171_absent_coat_pigmentation1.36583796
44MP0003634_abnormal_glial_cell1.36495467
45MP0004197_abnormal_fetal_growth/weight/1.34687192
46MP0000647_abnormal_sebaceous_gland1.33514347
47MP0002233_abnormal_nose_morphology1.33494740
48MP0003984_embryonic_growth_retardation1.31277675
49MP0003122_maternal_imprinting1.30436228
50MP0002111_abnormal_tail_morphology1.30379535
51MP0004885_abnormal_endolymph1.29828626
52MP0001188_hyperpigmentation1.28134691
53MP0001299_abnormal_eye_distance/1.27509122
54MP0000566_synostosis1.27400489
55MP0003786_premature_aging1.27160368
56MP0002088_abnormal_embryonic_growth/wei1.25987789
57MP0003121_genomic_imprinting1.22762158
58MP0000049_abnormal_middle_ear1.21630366
59MP0004134_abnormal_chest_morphology1.21430999
60MP0000462_abnormal_digestive_system1.20490392
61MP0002092_abnormal_eye_morphology1.16614504
62MP0003329_amyloid_beta_deposits1.15144037
63MP0008789_abnormal_olfactory_epithelium1.14903546
64MP0010307_abnormal_tumor_latency1.14679015
65MP0001177_atelectasis1.14650569
66MP0003632_abnormal_nervous_system1.13181822
67MP0002938_white_spotting1.11974356
68MP0003690_abnormal_glial_cell1.11022251
69MP0003806_abnormal_nucleotide_metabolis1.10393427
70MP0000762_abnormal_tongue_morphology1.10023314
71MP0003705_abnormal_hypodermis_morpholog1.06473492
72MP0004133_heterotaxia1.05896325
73MP0010352_gastrointestinal_tract_polyps1.04940427
74MP0003861_abnormal_nervous_system1.03970864
75MP0000747_muscle_weakness1.03827474
76MP0005394_taste/olfaction_phenotype1.03599221
77MP0005499_abnormal_olfactory_system1.03599221
78MP0003755_abnormal_palate_morphology1.03208766
79MP0003186_abnormal_redox_activity0.98689506
80MP0009250_abnormal_appendicular_skeleto0.98000594
81MP0002086_abnormal_extraembryonic_tissu0.97130565
82MP0002090_abnormal_vision0.96903976
83MP0004742_abnormal_vestibular_system0.96522792
84MP0002653_abnormal_ependyma_morphology0.94931380
85MP0000467_abnormal_esophagus_morphology0.93812300
86MP0002210_abnormal_sex_determination0.92100606
87MP0001145_abnormal_male_reproductive0.91700411
88MP0000432_abnormal_head_morphology0.91609939
89MP0001661_extended_life_span0.91031238
90MP0003315_abnormal_perineum_morphology0.89913783
91MP0004233_abnormal_muscle_weight0.89885476
92MP0003942_abnormal_urinary_system0.88629979
93MP0006035_abnormal_mitochondrial_morpho0.88234681
94MP0009672_abnormal_birth_weight0.85958441
95MP0000778_abnormal_nervous_system0.85479078
96MP0003890_abnormal_embryonic-extraembry0.85179488
97MP0003385_abnormal_body_wall0.84586768
98MP0001346_abnormal_lacrimal_gland0.84455526
99MP0006072_abnormal_retinal_apoptosis0.84450384
100MP0000313_abnormal_cell_death0.83515933
101MP0001542_abnormal_bone_strength0.83408547
102MP0000377_abnormal_hair_follicle0.83133860
103MP0009053_abnormal_anal_canal0.82132186
104MP0002114_abnormal_axial_skeleton0.81049947
105MP0002751_abnormal_autonomic_nervous0.80720213
106MP0002736_abnormal_nociception_after0.79959127
107MP0008877_abnormal_DNA_methylation0.79916004
108MP0003567_abnormal_fetal_cardiomyocyte0.79898949
109MP0001286_abnormal_eye_development0.79255235
110MP0009703_decreased_birth_body0.77682919
111MP0005508_abnormal_skeleton_morphology0.76353620
112MP0000358_abnormal_cell_content/0.76214031
113MP0005248_abnormal_Harderian_gland0.76012092
114MP0002396_abnormal_hematopoietic_system0.75888220
115MP0005501_abnormal_skin_physiology0.74677135
116MP0003935_abnormal_craniofacial_develop0.72256331
117MP0002697_abnormal_eye_size0.71762711
118MP0005391_vision/eye_phenotype0.71642270
119MP0001727_abnormal_embryo_implantation0.71485499
120MP0004272_abnormal_basement_membrane0.71304831
121MP0005621_abnormal_cell_physiology0.71105532
122MP0002932_abnormal_joint_morphology0.70970074
123MP0003221_abnormal_cardiomyocyte_apopto0.70694409
124MP0003119_abnormal_digestive_system0.70693581
125MP0003115_abnormal_respiratory_system0.70128529
126MP0001849_ear_inflammation0.70022571
127MP0002102_abnormal_ear_morphology0.69960196
128MP0004142_abnormal_muscle_tone0.69703468
129MP0001929_abnormal_gametogenesis0.69562219
130MP0000653_abnormal_sex_gland0.69099527
131MP0002081_perinatal_lethality0.69093597
132MP0003566_abnormal_cell_adhesion0.67313238
133MP0005187_abnormal_penis_morphology0.65731078
134MP0002796_impaired_skin_barrier0.65121310
135MP0005384_cellular_phenotype0.63381974
136MP0001915_intracranial_hemorrhage0.63068973

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.82835126
2Cortical dysplasia (HP:0002539)4.23458768
3Premature rupture of membranes (HP:0001788)3.74101897
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68231897
5CNS hypomyelination (HP:0003429)3.62287410
6Abnormality of the umbilical cord (HP:0010881)3.56764808
7Chromsome breakage (HP:0040012)3.40744324
8Breast hypoplasia (HP:0003187)3.40250653
9Birth length less than 3rd percentile (HP:0003561)3.29444457
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.25872026
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.25872026
12Abnormality of the labia minora (HP:0012880)3.17014398
13Meckel diverticulum (HP:0002245)3.06065313
14Peripheral hypomyelination (HP:0007182)3.05615328
15Abnormality of glycolysis (HP:0004366)3.03460647
16Increased serum pyruvate (HP:0003542)3.03460647
17Spastic diplegia (HP:0001264)3.00291525
18Absent radius (HP:0003974)2.99519579
19Nephroblastoma (Wilms tumor) (HP:0002667)2.90570180
20Hypoplastic pelvis (HP:0008839)2.88895630
21Absent forearm bone (HP:0003953)2.87238527
22Aplasia involving forearm bones (HP:0009822)2.87238527
23Alacrima (HP:0000522)2.86690754
24Abnormal auditory evoked potentials (HP:0006958)2.86321853
25Abnormality of the ileum (HP:0001549)2.85564346
26Esophageal atresia (HP:0002032)2.79830797
27Embryonal renal neoplasm (HP:0011794)2.77713294
28Hyperglycinemia (HP:0002154)2.77009788
29Morphological abnormality of the inner ear (HP:0011390)2.76654506
30Selective tooth agenesis (HP:0001592)2.65645846
31Abnormality of chromosome stability (HP:0003220)2.63886013
32Abnormal umbilical cord blood vessels (HP:0011403)2.61180721
33Single umbilical artery (HP:0001195)2.61180721
34Abnormality of the fetal cardiovascular system (HP:0010948)2.61180721
35Stenosis of the external auditory canal (HP:0000402)2.55491916
36Septo-optic dysplasia (HP:0100842)2.47983081
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.45289889
38Ureteral duplication (HP:0000073)2.42977288
39Medulloblastoma (HP:0002885)2.42911567
40Abnormality of the preputium (HP:0100587)2.41285580
41Rhabdomyosarcoma (HP:0002859)2.40365404
42Coronal craniosynostosis (HP:0004440)2.38959878
43Decreased lacrimation (HP:0000633)2.35693244
44Calcaneovalgus deformity (HP:0001848)2.35259676
45Hyperglycinuria (HP:0003108)2.33809724
46Hepatoblastoma (HP:0002884)2.31815423
47Abnormality of methionine metabolism (HP:0010901)2.27421215
48Glioma (HP:0009733)2.26931145
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25874235
50Duplicated collecting system (HP:0000081)2.25541878
51Neurofibrillary tangles (HP:0002185)2.25455443
52Rough bone trabeculation (HP:0100670)2.25434406
53Small intestinal stenosis (HP:0012848)2.24349003
54Duodenal stenosis (HP:0100867)2.24349003
55Insidious onset (HP:0003587)2.23404045
56Termporal pattern (HP:0011008)2.23404045
57Abnormalities of placenta or umbilical cord (HP:0001194)2.22153236
58Abnormality of the astrocytes (HP:0100707)2.20529163
59Astrocytoma (HP:0009592)2.20529163
60Abnormality of the corticospinal tract (HP:0002492)2.20260547
61Glossoptosis (HP:0000162)2.19324400
62Segmental peripheral demyelination/remyelination (HP:0003481)2.18516319
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.17009932
64Deformed tarsal bones (HP:0008119)2.15130853
65Proximal placement of thumb (HP:0009623)2.10532206
66Ectopic kidney (HP:0000086)2.09101564
67Trismus (HP:0000211)2.08489492
68Sensory axonal neuropathy (HP:0003390)2.08394318
69Absent septum pellucidum (HP:0001331)2.07232711
70Aplasia involving bones of the extremities (HP:0009825)2.06056777
71Aplasia involving bones of the upper limbs (HP:0009823)2.06056777
72Aplasia of the phalanges of the hand (HP:0009802)2.06056777
73Abnormality of the duodenum (HP:0002246)2.05857916
74Shallow orbits (HP:0000586)2.04978274
75* Postnatal microcephaly (HP:0005484)2.04070882
76Premature skin wrinkling (HP:0100678)2.03991143
77Carpal bone hypoplasia (HP:0001498)2.03730919
78Parakeratosis (HP:0001036)2.03046876
79Atresia of the external auditory canal (HP:0000413)2.02614630
80Megalencephaly (HP:0001355)2.02126185
81Split foot (HP:0001839)2.00122900
82Abnormality of the calcaneus (HP:0008364)1.98136522
83Abnormality of the salivary glands (HP:0010286)1.97900188
84Hypoglycemic seizures (HP:0002173)1.95251896
85Impulsivity (HP:0100710)1.94588226
86Abnormality of cochlea (HP:0000375)1.94462340
87Spastic paraparesis (HP:0002313)1.94461130
88Pancreatic islet-cell hyperplasia (HP:0004510)1.94091131
89Abnormality of the septum pellucidum (HP:0007375)1.92611760
90Abnormality of the carotid arteries (HP:0005344)1.92515344
91Triphalangeal thumb (HP:0001199)1.92057322
92Deviation of the thumb (HP:0009603)1.91986908
93Neoplasm of the colon (HP:0100273)1.91278263
94Cerebral inclusion bodies (HP:0100314)1.90823384
95Adrenal hypoplasia (HP:0000835)1.90075279
96Reticulocytopenia (HP:0001896)1.89917474
97Macrocytic anemia (HP:0001972)1.89298448
98Abnormality of the anterior horn cell (HP:0006802)1.89094834
99Degeneration of anterior horn cells (HP:0002398)1.89094834
100Megaloblastic anemia (HP:0001889)1.87908762
101Broad distal phalanx of finger (HP:0009836)1.87846647
102Embryonal neoplasm (HP:0002898)1.87610878
103* Abnormality of serum amino acid levels (HP:0003112)1.87089277
104Choanal stenosis (HP:0000452)1.86586782
105Bifid tongue (HP:0010297)1.85202030
106Neoplasm of the adrenal gland (HP:0100631)1.85040533
107Asplenia (HP:0001746)1.84863998
108Abnormality of the renal collecting system (HP:0004742)1.82952241
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82566976
110Patellar aplasia (HP:0006443)1.82332439
111Duplication of thumb phalanx (HP:0009942)1.81808818
112Fused cervical vertebrae (HP:0002949)1.81807760
113Facial cleft (HP:0002006)1.80540982
114Supernumerary spleens (HP:0009799)1.79765678
115Ankle contracture (HP:0006466)1.79545611
116Microglossia (HP:0000171)1.78894819
117Onion bulb formation (HP:0003383)1.78710046
118Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78374354
119Abnormal trabecular bone morphology (HP:0100671)1.77640058
120Aplasia/Hypoplasia of the patella (HP:0006498)1.76504596
121Aplasia/Hypoplasia of the breasts (HP:0010311)1.76200386
122Colon cancer (HP:0003003)1.75587518
123Abnormality of the antihelix (HP:0009738)1.75503415
124Horseshoe kidney (HP:0000085)1.74253688
125Partial duplication of thumb phalanx (HP:0009944)1.74032337
126Multiple enchondromatosis (HP:0005701)1.73647784
127Sparse lateral eyebrow (HP:0005338)1.73578606
128Choanal atresia (HP:0000453)1.73518279
129Osteolytic defects of the hand bones (HP:0009699)1.73287491
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.73287491
131Abnormal lung lobation (HP:0002101)1.73224116
132Partial duplication of the phalanx of hand (HP:0009999)1.72780509
133Ependymoma (HP:0002888)1.71343893
134Generalized hypotonia (HP:0001290)1.70520834
135Secondary amenorrhea (HP:0000869)1.70514459
136Aplasia/Hypoplasia of the spleen (HP:0010451)1.70409918
137Exercise-induced muscle cramps (HP:0003710)1.69872089
138* Abnormality of glycine metabolism (HP:0010895)1.69607933
139* Abnormality of serine family amino acid metabolism (HP:0010894)1.69607933
140Hyperinsulinemic hypoglycemia (HP:0000825)1.69552434
141Increased nuchal translucency (HP:0010880)1.68681078
142Upper limb muscle weakness (HP:0003484)1.68519637
143Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67239483
144Overriding aorta (HP:0002623)1.66980274
145Breast aplasia (HP:0100783)1.66429271
146* Sloping forehead (HP:0000340)1.66322021
147Agnosia (HP:0010524)1.65426684
148Facial hemangioma (HP:0000329)1.65056812
149Abnormal number of incisors (HP:0011064)1.64844383
150Premature graying of hair (HP:0002216)1.64527353
151Anteriorly placed anus (HP:0001545)1.63871245
152Microvesicular hepatic steatosis (HP:0001414)1.62918037
153Homocystinuria (HP:0002156)1.62703281
154Abnormality of homocysteine metabolism (HP:0010919)1.62703281
155Trigonocephaly (HP:0000243)1.61783556
156Abnormality of sulfur amino acid metabolism (HP:0004339)1.61512931
157Volvulus (HP:0002580)1.60751265
158Myelomeningocele (HP:0002475)1.60042754
159Hemivertebrae (HP:0002937)1.59873248
160Hypoplasia of the pons (HP:0012110)1.58036918
161Absent eyelashes (HP:0000561)1.55922007
162Abnormal hair whorl (HP:0010721)1.55305105
163Renal agenesis (HP:0000104)1.54484703
164Abnormality of the metopic suture (HP:0005556)1.53983680
165High anterior hairline (HP:0009890)1.53847921
166Long foot (HP:0001833)1.53313215
167Hypoplastic female external genitalia (HP:0012815)1.52071476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.44160053
2WEE13.71953660
3TESK23.27536367
4STK392.97097657
5CDC72.60031445
6VRK22.50898825
7TSSK62.46802297
8EIF2AK12.37888295
9MKNK12.21067831
10TTK2.14858815
11PNCK2.10184662
12TAF12.05712555
13NEK22.04550232
14TNIK2.03008024
15LIMK12.01219234
16TRIM281.96757605
17PBK1.91302378
18ZAK1.72420531
19PLK31.63343907
20OXSR11.61687474
21BRSK21.57179040
22MET1.56195138
23MAPKAPK51.51916028
24PLK11.51400755
25TLK11.50984483
26EPHB11.50655041
27EIF2AK31.48309929
28NEK11.44348616
29BCR1.43881545
30EPHA21.40734667
31MAP3K81.37086350
32SRPK11.35517215
33STK161.30979537
34ALK1.28488116
35NME21.23774896
36CSNK1G31.23228777
37MKNK21.21644505
38WNK31.20840893
39CHEK21.18729654
40NUAK11.16203442
41CSNK1A1L1.16082484
42AURKB1.14396274
43PLK41.13520697
44MST41.13433201
45SMG11.13050497
46MAP3K101.12111946
47FGFR21.11871803
48BRSK11.09714122
49PAK11.09320922
50AURKA1.09069505
51ERBB41.08634268
52PLK21.07962278
53CHEK11.07862466
54UHMK11.07559286
55VRK11.04748906
56ROCK21.04430767
57CASK1.04369413
58EEF2K1.03724388
59PASK1.03258778
60DYRK31.02712927
61NME11.01964647
62TYRO30.98629340
63CDK70.97109924
64PKN10.96917641
65STK38L0.95396894
66CSNK1G10.94660007
67EIF2AK20.94470669
68DYRK20.91186985
69SCYL20.89489002
70CDK140.88317646
71PAK20.85930642
72STK100.85754187
73RPS6KB20.84920060
74LATS10.82823095
75ATR0.81478627
76CLK10.79575379
77PAK40.78199667
78CDK150.77920953
79DDR20.76153168
80RPS6KA50.75551671
81MELK0.73438041
82BMPR1B0.73273237
83CDK11A0.72430347
84CDK190.72024302
85PRKD30.71698073
86CDK180.71589923
87CDK20.70690180
88STK30.69246671
89FGFR10.67342641
90ILK0.66810325
91CSNK1E0.66473900
92STK40.66370157
93LATS20.66179259
94CSNK1G20.65534572
95TESK10.64940607
96CDK10.64541971
97LRRK20.62590960
98NEK60.61577165
99CDK40.61221415
100TGFBR10.60443187
101ERBB30.57830666
102BMX0.55420871
103PDK20.55263304
104CSNK1D0.53985649
105CSNK2A20.53870184
106BRD40.52103869
107RPS6KA40.51701044
108ICK0.51647848
109BRAF0.50789341
110ATM0.50690590
111MTOR0.50550564
112WNK10.48172596
113CAMK2B0.46858053
114CCNB10.46667472
115PDGFRA0.45981044
116EPHA40.45554771
117MINK10.45253757
118DAPK10.41771905
119ACVR1B0.40597698
120WNK40.40070987
121CDK30.39722049
122PAK60.38943213
123CDK90.38478414
124FGR0.38213587
125CSNK2A10.36652794
126PRKDC0.34939701
127STK240.33141047
128CDK60.32126836
129FLT30.31785590
130NTRK10.30616828
131YES10.30574235
132CAMK1G0.29159872
133MAP4K20.28727082

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.02134686
2DNA replication_Homo sapiens_hsa030303.63407343
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55655431
4RNA polymerase_Homo sapiens_hsa030203.29950959
5RNA transport_Homo sapiens_hsa030133.14466059
6Mismatch repair_Homo sapiens_hsa034303.04579045
7Spliceosome_Homo sapiens_hsa030402.87912357
8Steroid biosynthesis_Homo sapiens_hsa001002.83667503
9Proteasome_Homo sapiens_hsa030502.81256558
10Cell cycle_Homo sapiens_hsa041102.63524376
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63319863
12Ribosome_Homo sapiens_hsa030102.47941111
13One carbon pool by folate_Homo sapiens_hsa006702.46046798
14Nucleotide excision repair_Homo sapiens_hsa034202.40479959
15Homologous recombination_Homo sapiens_hsa034402.17869632
16Base excision repair_Homo sapiens_hsa034102.07770317
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.02330296
18Basal transcription factors_Homo sapiens_hsa030221.91657700
19Pyruvate metabolism_Homo sapiens_hsa006201.84901870
20Fatty acid elongation_Homo sapiens_hsa000621.70000253
21mRNA surveillance pathway_Homo sapiens_hsa030151.69087075
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67813651
23Propanoate metabolism_Homo sapiens_hsa006401.64219862
24Pyrimidine metabolism_Homo sapiens_hsa002401.61377786
25Selenocompound metabolism_Homo sapiens_hsa004501.59335816
26Fanconi anemia pathway_Homo sapiens_hsa034601.54469728
27Non-homologous end-joining_Homo sapiens_hsa034501.52361889
28Ether lipid metabolism_Homo sapiens_hsa005651.49807538
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40933643
30Oocyte meiosis_Homo sapiens_hsa041141.32458556
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31353805
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.29513906
33* Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25122984
34Nitrogen metabolism_Homo sapiens_hsa009101.22886470
35p53 signaling pathway_Homo sapiens_hsa041151.20366796
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.15054815
37RNA degradation_Homo sapiens_hsa030181.12548951
38Protein export_Homo sapiens_hsa030601.07468194
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07402544
40Folate biosynthesis_Homo sapiens_hsa007901.06448652
41Tight junction_Homo sapiens_hsa045301.05628179
42Hippo signaling pathway_Homo sapiens_hsa043901.04873640
43Systemic lupus erythematosus_Homo sapiens_hsa053221.04074787
44Purine metabolism_Homo sapiens_hsa002301.01023853
45Viral carcinogenesis_Homo sapiens_hsa052031.00886307
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98514855
47Epstein-Barr virus infection_Homo sapiens_hsa051690.93856119
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93197764
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92459092
50Hedgehog signaling pathway_Homo sapiens_hsa043400.89943798
51* Biosynthesis of amino acids_Homo sapiens_hsa012300.88697777
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86011652
53Renal cell carcinoma_Homo sapiens_hsa052110.85912063
54MicroRNAs in cancer_Homo sapiens_hsa052060.84574162
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.84390023
56Arginine biosynthesis_Homo sapiens_hsa002200.84222705
57Glutathione metabolism_Homo sapiens_hsa004800.82832992
58Fatty acid metabolism_Homo sapiens_hsa012120.82598434
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81768498
60Pentose phosphate pathway_Homo sapiens_hsa000300.81451286
61Lysine degradation_Homo sapiens_hsa003100.81305585
62Arginine and proline metabolism_Homo sapiens_hsa003300.80588853
63Basal cell carcinoma_Homo sapiens_hsa052170.79283625
64Alcoholism_Homo sapiens_hsa050340.74250358
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73058519
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69241239
67Linoleic acid metabolism_Homo sapiens_hsa005910.68123091
68beta-Alanine metabolism_Homo sapiens_hsa004100.62621319
69Fatty acid degradation_Homo sapiens_hsa000710.61812675
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61653142
71Parkinsons disease_Homo sapiens_hsa050120.61122263
72Sphingolipid metabolism_Homo sapiens_hsa006000.60061862
73Small cell lung cancer_Homo sapiens_hsa052220.58338433
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55767307
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55056745
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53170107
77TGF-beta signaling pathway_Homo sapiens_hsa043500.52778153
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51857299
79Prostate cancer_Homo sapiens_hsa052150.49850723
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49554676
81Axon guidance_Homo sapiens_hsa043600.49487641
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.48827391
83HTLV-I infection_Homo sapiens_hsa051660.47767733
84Bladder cancer_Homo sapiens_hsa052190.45928914
85Endocytosis_Homo sapiens_hsa041440.45789847
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45059912
87ECM-receptor interaction_Homo sapiens_hsa045120.45009098
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44284489
89N-Glycan biosynthesis_Homo sapiens_hsa005100.42878175
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42208341
91Butanoate metabolism_Homo sapiens_hsa006500.41106247
92Oxidative phosphorylation_Homo sapiens_hsa001900.40922122
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40908087
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40563902
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.40199303
96Galactose metabolism_Homo sapiens_hsa000520.39244281
97Pathways in cancer_Homo sapiens_hsa052000.39061703
98Peroxisome_Homo sapiens_hsa041460.38961524
99Fatty acid biosynthesis_Homo sapiens_hsa000610.38671119
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37017677
101Notch signaling pathway_Homo sapiens_hsa043300.35460825
102Vitamin digestion and absorption_Homo sapiens_hsa049770.35446360
103Wnt signaling pathway_Homo sapiens_hsa043100.33939131
104Fructose and mannose metabolism_Homo sapiens_hsa000510.33233688
105Arachidonic acid metabolism_Homo sapiens_hsa005900.32595085
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32513663
107Sulfur relay system_Homo sapiens_hsa041220.32272813
108Regulation of autophagy_Homo sapiens_hsa041400.31087065
109Proteoglycans in cancer_Homo sapiens_hsa052050.30820609
110Melanoma_Homo sapiens_hsa052180.29040229
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.28554756
112Shigellosis_Homo sapiens_hsa051310.27759543
113Colorectal cancer_Homo sapiens_hsa052100.25517290
114* Metabolic pathways_Homo sapiens_hsa011000.23980175
115Retinol metabolism_Homo sapiens_hsa008300.23432139
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22085750
117* Carbon metabolism_Homo sapiens_hsa012000.21780122
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20319867
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.20171447
120Thyroid cancer_Homo sapiens_hsa052160.19679040
121Alzheimers disease_Homo sapiens_hsa050100.19379825
122Histidine metabolism_Homo sapiens_hsa003400.18555293
123Focal adhesion_Homo sapiens_hsa045100.17797539
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.17191248
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16988850
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15604204
127Tyrosine metabolism_Homo sapiens_hsa003500.15472194
128Chronic myeloid leukemia_Homo sapiens_hsa052200.15029289
129Tryptophan metabolism_Homo sapiens_hsa003800.14075801
130Melanogenesis_Homo sapiens_hsa049160.13493207
131Gap junction_Homo sapiens_hsa045400.13349630
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.12501916
133Huntingtons disease_Homo sapiens_hsa050160.12207065
134Fat digestion and absorption_Homo sapiens_hsa049750.11996823
135Adherens junction_Homo sapiens_hsa045200.11800123
136Thyroid hormone synthesis_Homo sapiens_hsa049180.11532687

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